PPP4R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.48619365
2nuclear pore complex assembly (GO:0051292)4.97724745
3nuclear pore organization (GO:0006999)4.73948127
4hypotonic response (GO:0006971)4.73201149
5desmosome organization (GO:0002934)4.31834546
6cell adhesion mediated by integrin (GO:0033627)4.23059296
7protein localization to endosome (GO:0036010)4.21609258
8heterochromatin organization (GO:0070828)4.09631217
9skin morphogenesis (GO:0043589)4.08404028
10pore complex assembly (GO:0046931)3.93161896
11cell-substrate junction assembly (GO:0007044)3.90295704
12fusion of sperm to egg plasma membrane (GO:0007342)3.71460831
13regulation of hippo signaling (GO:0035330)3.70009882
14dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.67403612
15protein localization to kinetochore (GO:0034501)3.65043085
16protein localization to chromosome, centromeric region (GO:0071459)3.62114013
17chromosome condensation (GO:0030261)3.59661281
18detection of molecule of bacterial origin (GO:0032490)3.56217785
19binding of sperm to zona pellucida (GO:0007339)3.55816113
20mitotic nuclear envelope disassembly (GO:0007077)3.53352150
21sperm-egg recognition (GO:0035036)3.53231536
22NLS-bearing protein import into nucleus (GO:0006607)3.41124320
23negative regulation of anoikis (GO:2000811)3.37290139
24negative regulation of keratinocyte proliferation (GO:0010839)3.36216862
25mitotic sister chromatid cohesion (GO:0007064)3.35927504
26nuclear envelope disassembly (GO:0051081)3.31808865
27membrane disassembly (GO:0030397)3.31808865
28positive regulation of Cdc42 GTPase activity (GO:0043089)3.31260119
29DNA packaging (GO:0006323)3.31066579
30bundle of His cell to Purkinje myocyte communication (GO:0086069)3.28638751
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24823659
32regulation of transforming growth factor beta2 production (GO:0032909)3.24649733
33cell-cell recognition (GO:0009988)3.24244894
34surfactant homeostasis (GO:0043129)3.22858284
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.22057063
36mRNA stabilization (GO:0048255)3.19453183
37RNA stabilization (GO:0043489)3.19453183
38cell wall macromolecule metabolic process (GO:0044036)3.18302253
39cell wall macromolecule catabolic process (GO:0016998)3.18302253
40mitotic chromosome condensation (GO:0007076)3.17879270
41mesodermal cell differentiation (GO:0048333)3.14756052
42pre-miRNA processing (GO:0031054)3.14565917
43DNA replication-dependent nucleosome organization (GO:0034723)3.11167202
44DNA replication-dependent nucleosome assembly (GO:0006335)3.11167202
45regulation of histone H3-K9 methylation (GO:0051570)3.10950692
46epithelial cell differentiation involved in prostate gland development (GO:0060742)3.07951809
47DNA unwinding involved in DNA replication (GO:0006268)3.07799948
48synaptonemal complex assembly (GO:0007130)3.06101774
49regulation of SMAD protein import into nucleus (GO:0060390)3.02597354
50embryonic process involved in female pregnancy (GO:0060136)2.99988275
51monoubiquitinated protein deubiquitination (GO:0035520)2.99928598
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98330764
53gene silencing by RNA (GO:0031047)2.97773729
54membrane raft organization (GO:0031579)2.97700500
55paraxial mesoderm development (GO:0048339)2.96437691
56negative regulation of chondrocyte differentiation (GO:0032331)2.96188277
57substrate-dependent cell migration (GO:0006929)2.95882580
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95514075
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95514075
60positive regulation by organism of defense response of other organism involved in symbiotic interact2.95514075
61modulation by symbiont of host immune response (GO:0052553)2.95514075
62positive regulation by symbiont of host defense response (GO:0052509)2.95514075
63modulation by symbiont of host defense response (GO:0052031)2.95514075
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95346386
65sperm motility (GO:0030317)2.94969813
66planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94106423
67sister chromatid segregation (GO:0000819)2.92033919
68morphogenesis of an endothelium (GO:0003159)2.90892075
69endothelial tube morphogenesis (GO:0061154)2.90892075
70regulation of translational fidelity (GO:0006450)2.86247998
71acrosome assembly (GO:0001675)2.85208114
72negative regulation of histone methylation (GO:0031061)2.84645649
73regulation of gene silencing by RNA (GO:0060966)2.84585557
74regulation of posttranscriptional gene silencing (GO:0060147)2.84585557
75regulation of gene silencing by miRNA (GO:0060964)2.84585557
76positive regulation of receptor recycling (GO:0001921)2.83597165
77chromatin assembly (GO:0031497)2.82457136
78regulation of water loss via skin (GO:0033561)2.81900464
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80854854
80regulation of spindle organization (GO:0090224)2.80209716
81peptidyl-lysine dimethylation (GO:0018027)2.79800936
82spliceosomal tri-snRNP complex assembly (GO:0000244)2.78697957
83mitotic sister chromatid segregation (GO:0000070)2.75529586
84gene silencing (GO:0016458)2.75376763
85establishment of skin barrier (GO:0061436)2.74711094
86synaptonemal complex organization (GO:0070193)2.73952068
87regulation of RNA export from nucleus (GO:0046831)2.72480754
88nuclear envelope organization (GO:0006998)2.71920341
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.71517626
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71517626
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71517626
92chaperone-mediated protein complex assembly (GO:0051131)2.71468264
93adherens junction assembly (GO:0034333)2.71346692
94iron ion import (GO:0097286)2.70549496
95dosage compensation (GO:0007549)2.70214839
96wound healing, spreading of epidermal cells (GO:0035313)2.68386858
97hippo signaling (GO:0035329)2.68082601
98epithelial cell-cell adhesion (GO:0090136)2.67876096
99translesion synthesis (GO:0019985)2.67763584
100keratinocyte differentiation (GO:0030216)2.67274378
101Golgi transport vesicle coating (GO:0048200)2.66630153
102COPI coating of Golgi vesicle (GO:0048205)2.66630153
103negative regulation of DNA repair (GO:0045738)2.65036840
104regulation of anoikis (GO:2000209)2.64599285
105regulation of mitotic spindle organization (GO:0060236)2.62986872
106wound healing, spreading of cells (GO:0044319)2.62601024
107keratinocyte proliferation (GO:0043616)2.62461662
108DNA conformation change (GO:0071103)2.62422060
109chemical homeostasis within a tissue (GO:0048875)2.61700404
110cell-substrate adherens junction assembly (GO:0007045)2.61666926
111focal adhesion assembly (GO:0048041)2.61666926
112endodermal cell differentiation (GO:0035987)2.61501692
113mammary gland epithelial cell proliferation (GO:0033598)2.60750991
114folic acid-containing compound biosynthetic process (GO:0009396)2.59587942
115response to laminar fluid shear stress (GO:0034616)2.59457113
116plasma membrane fusion (GO:0045026)2.58695036
117DNA geometric change (GO:0032392)2.58411155
118establishment of tissue polarity (GO:0007164)2.58276763
119establishment of planar polarity (GO:0001736)2.58276763
120detection of external biotic stimulus (GO:0098581)2.58267310
121negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.58166526
122DNA duplex unwinding (GO:0032508)2.57857019
123regulation of sister chromatid cohesion (GO:0007063)2.56458067
124response to UV-C (GO:0010225)2.55950900
125histone H2A monoubiquitination (GO:0035518)2.55544615
126regulation of translational termination (GO:0006449)2.52261138
127spermatid development (GO:0007286)2.52028053
128interferon-gamma secretion (GO:0072643)2.51866382
129cellular protein complex localization (GO:0034629)2.51487976
130stress fiber assembly (GO:0043149)2.50543780
131regulation of mRNA stability (GO:0043488)2.49182315
132apoptotic cell clearance (GO:0043277)2.48707944
133glucocorticoid receptor signaling pathway (GO:0042921)2.48669123
134keratinization (GO:0031424)2.48083378
135protein localization to microtubule (GO:0035372)2.47969850
136positive regulation of chromosome segregation (GO:0051984)2.47145417
137barbed-end actin filament capping (GO:0051016)2.43772413
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.43127085
139cytoskeleton-dependent cytokinesis (GO:0061640)2.42810362
1403-UTR-mediated mRNA stabilization (GO:0070935)2.42192912
141gap junction assembly (GO:0016264)2.41937908
142protein localization to chromosome (GO:0034502)2.41262645
143positive regulation of cell junction assembly (GO:1901890)2.40093260
144positive regulation of focal adhesion assembly (GO:0051894)2.40093260
145piRNA metabolic process (GO:0034587)2.38649959
146detection of other organism (GO:0098543)2.38091419
147trophectodermal cell differentiation (GO:0001829)2.38027697
148regulation of RNA stability (GO:0043487)2.37946746
149motile cilium assembly (GO:0044458)2.37726093
150positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37676644
151positive regulation of adherens junction organization (GO:1903393)2.37445294
152mitotic cytokinesis (GO:0000281)2.36913934
153regulation of NFAT protein import into nucleus (GO:0051532)2.36604623
154COPII vesicle coating (GO:0048208)2.36360263
155regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.36053404
156multicellular organism reproduction (GO:0032504)2.35539508
157regulation of chromosome segregation (GO:0051983)2.34294499
158membrane protein ectodomain proteolysis (GO:0006509)2.33318176
159regulation of centriole replication (GO:0046599)2.31811375
160positive regulation of protein import into nucleus, translocation (GO:0033160)2.31578060
161positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30484487
162detection of biotic stimulus (GO:0009595)2.29025160
163regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26936197
164regulation of DNA damage checkpoint (GO:2000001)2.26427767
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25380098
166establishment of chromosome localization (GO:0051303)2.25156297
167response to peptidoglycan (GO:0032494)2.25037754
168cytoplasmic mRNA processing body assembly (GO:0033962)2.24699266
169morphogenesis of an epithelial sheet (GO:0002011)2.24155808
170chromatin silencing (GO:0006342)2.24048022
171regulation of protein polyubiquitination (GO:1902914)2.23628864
172nucleosome disassembly (GO:0006337)2.23389552
173protein-DNA complex disassembly (GO:0032986)2.23389552
174microtubule depolymerization (GO:0007019)2.22875288
175male meiosis (GO:0007140)2.22691357
176regulation of keratinocyte proliferation (GO:0010837)2.20107493
177mitotic metaphase plate congression (GO:0007080)2.20064647
178macrophage activation involved in immune response (GO:0002281)2.18910674
179negative regulation of protein localization to plasma membrane (GO:1903077)2.18411748
180negative regulation of fatty acid transport (GO:2000192)2.17973529
181histone H3-K36 demethylation (GO:0070544)2.17932143
182cell junction assembly (GO:0034329)2.17099335
183response to host (GO:0075136)2.17053104
184response to host defenses (GO:0052200)2.17053104
185response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17053104
186platelet-derived growth factor receptor signaling pathway (GO:0048008)2.17050412
187peptidyl-threonine modification (GO:0018210)2.16899212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14172687
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77721052
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.49777781
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.12679707
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.59761206
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27113597
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53488713
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49211439
9MYC_22102868_ChIP-Seq_BL_Human2.45421063
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43717622
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.35313331
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.18726920
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.18032740
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13138987
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.12505417
16SOX9_24532713_ChIP-Seq_HFSC_Mouse2.03561230
17AR_21909140_ChIP-Seq_LNCAP_Human2.03022465
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95267149
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87183737
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85797425
21FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.84915946
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.82805733
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82431199
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.76982203
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76937901
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76409289
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75532294
28ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.73886796
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.73788948
30SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69744122
31TCF7_22412390_ChIP-Seq_EML_Mouse1.69644931
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.69431386
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68053904
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62346241
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59904249
36* CJUN_26792858_Chip-Seq_BT549_Human1.58261103
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56359786
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55977096
39* VDR_21846776_ChIP-Seq_THP-1_Human1.54522296
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53653833
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52825115
42* GATA2_21666600_ChIP-Seq_HMVEC_Human1.52595681
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51301284
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48815832
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48350905
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47951162
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47927617
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46647214
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.44636783
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44389490
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44153600
52CLOCK_20551151_ChIP-Seq_293T_Human1.38337007
53ATF3_27146783_Chip-Seq_COLON_Human1.38319457
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.37969762
55* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37225085
56* TP63_23658742_ChIP-Seq_EP156T_Human1.35676732
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33899299
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33866593
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33570817
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.32147274
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31591254
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30974983
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29286270
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28960526
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28817054
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27743850
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27187569
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27035292
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25851675
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25705635
71TP53_16413492_ChIP-PET_HCT116_Human1.24573635
72AHR_22903824_ChIP-Seq_MCF-7_Human1.24342152
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23929303
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.23550812
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23434868
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23355262
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22821758
78KDM2B_26808549_Chip-Seq_DND41_Human1.17237503
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17069277
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17053959
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16620440
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.16045189
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15470803
84SOX2_20726797_ChIP-Seq_SW620_Human1.15112783
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15072490
86* TP53_22127205_ChIP-Seq_IMR90_Human1.14610567
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13821287
88KDM5A_27292631_Chip-Seq_BREAST_Human1.13669789
89* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13594890
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.13455929
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.13305569
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13013229
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11120244
94* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10743513
95UTX_26944678_Chip-Seq_JUKART_Human1.10315227
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10252210
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09962572
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09888493
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.09734343
100* NCOR1_26117541_ChIP-Seq_K562_Human1.09596738
101ZNF263_19887448_ChIP-Seq_K562_Human1.09393117
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08898305
103MAF_26560356_Chip-Seq_TH1_Human1.08675034
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08409689
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08169301
106TFEB_21752829_ChIP-Seq_HELA_Human1.07943943
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07794824
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07535095
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06077951
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05954353
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05888524
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05888524
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05869807
114* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04866899
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03822185
116KLF5_25053715_ChIP-Seq_YYC3_Human1.03687581
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03603272
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.03593264
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.03593264
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02528896
121* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02324067
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.01332257
123TP53_18474530_ChIP-ChIP_U2OS_Human1.01033510
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00436475
125* BRD4_25478319_ChIP-Seq_HGPS_Human1.00345776
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.99875661
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99146569
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98861021
129CIITA_25753668_ChIP-Seq_RAJI_Human0.97809282
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96978278
131GATA6_25053715_ChIP-Seq_YYC3_Human0.96043743
132CHD1_26751641_Chip-Seq_LNCaP_Human0.95492488
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95247016
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94865186
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94428630
136ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94141836
137MYB_26560356_Chip-Seq_TH1_Human0.93883945
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.93358059
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92834403
140IRF8_22096565_ChIP-ChIP_GC-B_Human0.92815446
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92278680
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91053167
143RACK7_27058665_Chip-Seq_MCF-7_Human0.90868238
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89540379
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89540379
146MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89457180
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89073799
148VDR_24763502_ChIP-Seq_THP-1_Human0.87548854
149PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87088422
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87036562
151XRN2_22483619_ChIP-Seq_HELA_Human0.85399159
152MYB_26560356_Chip-Seq_TH2_Human0.85103084
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85014417
154* RUNX1_22412390_ChIP-Seq_EML_Mouse0.84406240
155ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83660779
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83441420
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82123344
158SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81868187
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81298213
160IRF8_21731497_ChIP-ChIP_J774_Mouse0.80813396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.71713306
2MP0010352_gastrointestinal_tract_polyps3.09295383
3MP0005410_abnormal_fertilization2.60432405
4MP0005076_abnormal_cell_differentiation2.44601881
5MP0000569_abnormal_digit_pigmentation2.42419768
6MP0003111_abnormal_nucleus_morphology2.39076055
7MP0008438_abnormal_cutaneous_collagen2.38414082
8MP0002796_impaired_skin_barrier2.32356632
9MP0008260_abnormal_autophagy2.32111946
10MP0003453_abnormal_keratinocyte_physiol2.26902712
11MP0003191_abnormal_cellular_cholesterol2.26892230
12MP0009278_abnormal_bone_marrow2.21219817
13MP0005409_darkened_coat_color2.17662253
14MP0003566_abnormal_cell_adhesion2.12414780
15MP0010678_abnormal_skin_adnexa2.11324356
16MP0003950_abnormal_plasma_membrane2.09827675
17MP0010307_abnormal_tumor_latency2.06611670
18MP0000579_abnormal_nail_morphology2.06491523
19MP0010094_abnormal_chromosome_stability1.90239452
20MP0003077_abnormal_cell_cycle1.88800753
21MP0004957_abnormal_blastocyst_morpholog1.85860747
22MP0010368_abnormal_lymphatic_system1.81893781
23MP0008007_abnormal_cellular_replicative1.78462567
24MP0003693_abnormal_embryo_hatching1.76844692
25MP0001730_embryonic_growth_arrest1.76606773
26MP0003828_pulmonary_edema1.70206221
27MP0000467_abnormal_esophagus_morphology1.69930580
28MP0001216_abnormal_epidermal_layer1.68139755
29MP0005023_abnormal_wound_healing1.67198674
30MP0000762_abnormal_tongue_morphology1.66986659
31MP0000383_abnormal_hair_follicle1.63516075
32MP0000537_abnormal_urethra_morphology1.63088850
33MP0004197_abnormal_fetal_growth/weight/1.58345423
34MP0003984_embryonic_growth_retardation1.56991296
35MP0000733_abnormal_muscle_development1.56621431
36MP0005380_embryogenesis_phenotype1.55820892
37MP0001672_abnormal_embryogenesis/_devel1.55820892
38MP0002088_abnormal_embryonic_growth/wei1.55316044
39MP0006054_spinal_hemorrhage1.54774503
40MP0009053_abnormal_anal_canal1.53481722
41MP0004808_abnormal_hematopoietic_stem1.52027906
42MP0000350_abnormal_cell_proliferation1.51945174
43MP0005257_abnormal_intraocular_pressure1.46812040
44MP0005501_abnormal_skin_physiology1.43873277
45MP0005248_abnormal_Harderian_gland1.43679320
46MP0002086_abnormal_extraembryonic_tissu1.43519953
47MP0003300_gastrointestinal_ulcer1.42899556
48MP0005623_abnormal_meninges_morphology1.39897211
49MP0003115_abnormal_respiratory_system1.39404317
50MP0002653_abnormal_ependyma_morphology1.39341251
51MP0003091_abnormal_cell_migration1.36709696
52MP0001697_abnormal_embryo_size1.35722869
53MP0001915_intracranial_hemorrhage1.32939221
54MP0005451_abnormal_body_composition1.32776262
55MP0003724_increased_susceptibility_to1.32358995
56MP0008057_abnormal_DNA_replication1.31336754
57MP0005275_abnormal_skin_tensile1.30954119
58MP0005164_abnormal_response_to1.30268625
59MP0002084_abnormal_developmental_patter1.30026829
60MP0001849_ear_inflammation1.28574985
61MP0004272_abnormal_basement_membrane1.25527738
62MP0010030_abnormal_orbit_morphology1.23767544
63MP0004233_abnormal_muscle_weight1.23364221
64MP0003567_abnormal_fetal_cardiomyocyte1.23022875
65MP0002085_abnormal_embryonic_tissue1.21412967
66MP0004883_abnormal_blood_vessel1.21388488
67MP0004084_abnormal_cardiac_muscle1.19515486
68MP0003123_paternal_imprinting1.19513325
69MP0002396_abnormal_hematopoietic_system1.19389433
70MP0005397_hematopoietic_system_phenotyp1.18284396
71MP0001545_abnormal_hematopoietic_system1.18284396
72MP0003279_aneurysm1.17304007
73MP0002080_prenatal_lethality1.16752588
74MP0000377_abnormal_hair_follicle1.16173263
75MP0001929_abnormal_gametogenesis1.16172294
76MP0001958_emphysema1.14694032
77MP0004947_skin_inflammation1.14027213
78MP0010234_abnormal_vibrissa_follicle1.11706783
79MP0002098_abnormal_vibrissa_morphology1.10710052
80MP0004264_abnormal_extraembryonic_tissu1.09534114
81MP0008877_abnormal_DNA_methylation1.09200682
82MP0000490_abnormal_crypts_of1.08563743
83MP0010771_integument_phenotype1.03709772
84MP0002925_abnormal_cardiovascular_devel1.01563247
85MP0000566_synostosis1.00488821
86MP0002877_abnormal_melanocyte_morpholog0.99130720
87MP0003890_abnormal_embryonic-extraembry0.98775103
88MP0005670_abnormal_white_adipose0.97898375
89MP0003303_peritoneal_inflammation0.97216744
90MP0003698_abnormal_male_reproductive0.96983409
91MP0003878_abnormal_ear_physiology0.96577208
92MP0005377_hearing/vestibular/ear_phenot0.96577208
93MP0003221_abnormal_cardiomyocyte_apopto0.95894015
94MP0004858_abnormal_nervous_system0.94097890
95MP0001293_anophthalmia0.93844026
96MP0004782_abnormal_surfactant_physiolog0.93657976
97MP0001851_eye_inflammation0.91403221
98MP0003448_altered_tumor_morphology0.91380692
99MP0008932_abnormal_embryonic_tissue0.90672603
100MP0010630_abnormal_cardiac_muscle0.90646578
101MP0002210_abnormal_sex_determination0.90360242
102MP0002092_abnormal_eye_morphology0.90235225
103MP0002697_abnormal_eye_size0.89743304
104MP0001243_abnormal_dermal_layer0.89107345
105MP0001879_abnormal_lymphatic_vessel0.89058777
106MP0005503_abnormal_tendon_morphology0.88302298
107MP0002133_abnormal_respiratory_system0.88036830
108MP0005388_respiratory_system_phenotype0.88036830
109MP0009672_abnormal_birth_weight0.87888406
110MP0000465_gastrointestinal_hemorrhage0.86790962
111MP0000428_abnormal_craniofacial_morphol0.86194538
112MP0000767_abnormal_smooth_muscle0.85740112
113MP0002896_abnormal_bone_mineralization0.84912206
114MP0000858_altered_metastatic_potential0.84818665
115MP0005621_abnormal_cell_physiology0.84354823
116MP0004185_abnormal_adipocyte_glucose0.84111417
117MP0001145_abnormal_male_reproductive0.82608303
118MP0002282_abnormal_trachea_morphology0.81504790
119MP0009840_abnormal_foam_cell0.80119948
120MP0000266_abnormal_heart_morphology0.79574554
121MP0000313_abnormal_cell_death0.79431535
122MP0002019_abnormal_tumor_incidence0.78985835
123MP0009703_decreased_birth_body0.78205690
124MP0000371_diluted_coat_color0.77945738
125MP0008058_abnormal_DNA_repair0.77066155
126MP0000432_abnormal_head_morphology0.76995974
127MP0003937_abnormal_limbs/digits/tail_de0.76914876
128MP0003935_abnormal_craniofacial_develop0.76424221
129MP0005197_abnormal_uvea_morphology0.76278071
130MP0003755_abnormal_palate_morphology0.76121500
131MP0003385_abnormal_body_wall0.75896937
132MP0009931_abnormal_skin_appearance0.75832205
133MP0000534_abnormal_ureter_morphology0.75618046
134MP0002060_abnormal_skin_morphology0.75412898
135MP0003941_abnormal_skin_development0.75053559
136MP0001614_abnormal_blood_vessel0.74842604
137MP0005193_abnormal_anterior_eye0.73593054
138MP0003436_decreased_susceptibility_to0.73373169
139MP0001299_abnormal_eye_distance/0.72833228
140MP0001175_abnormal_lung_morphology0.72710069
141MP0004381_abnormal_hair_follicle0.72493941
142MP0002111_abnormal_tail_morphology0.72378393
143MP0005384_cellular_phenotype0.72275261
144MP0000477_abnormal_intestine_morphology0.70669184

Predicted human phenotypes

RankGene SetZ-score
1Thick nail (HP:0001805)4.16892066
2Abnormality of nail color (HP:0100643)4.05788573
3Milia (HP:0001056)3.46661696
4Protrusio acetabuli (HP:0003179)3.38740981
5Alopecia of scalp (HP:0002293)3.33924344
6Arterial tortuosity (HP:0005116)3.25017665
7Ankyloglossia (HP:0010296)3.15609158
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14627723
9Short 4th metacarpal (HP:0010044)3.14627723
10Cerebral aneurysm (HP:0004944)3.13680812
11Onycholysis (HP:0001806)3.11992449
12Vascular tortuosity (HP:0004948)2.99161964
13Shallow orbits (HP:0000586)2.92379923
14Plantar hyperkeratosis (HP:0007556)2.86684044
15Ankle contracture (HP:0006466)2.70260085
16Premature rupture of membranes (HP:0001788)2.68118291
17Hand muscle atrophy (HP:0009130)2.64816641
18Aortic aneurysm (HP:0004942)2.63898493
19Right ventricular cardiomyopathy (HP:0011663)2.63304306
20Abnormality of oral frenula (HP:0000190)2.57902591
21Cervical subluxation (HP:0003308)2.57233876
22Fragile nails (HP:0001808)2.53328990
23Fragile skin (HP:0001030)2.49459257
24Nail dystrophy (HP:0008404)2.44655351
25Palmoplantar hyperkeratosis (HP:0000972)2.43633113
26Selective tooth agenesis (HP:0001592)2.43434112
27Palmar hyperkeratosis (HP:0010765)2.43290597
28Vertebral arch anomaly (HP:0008438)2.42469114
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37245257
30Subacute progressive viral hepatitis (HP:0006572)2.35919466
31Distal upper limb amyotrophy (HP:0007149)2.35764919
32Upper limb amyotrophy (HP:0009129)2.35764919
33Abnormality of the 4th metacarpal (HP:0010012)2.34736088
34Peritonitis (HP:0002586)2.31321980
35Papillary thyroid carcinoma (HP:0002895)2.27230402
36Male infertility (HP:0003251)2.24874807
37Hyperacusis (HP:0010780)2.22824008
38Ependymoma (HP:0002888)2.22532793
39Eczematoid dermatitis (HP:0000976)2.21386066
40Natal tooth (HP:0000695)2.21346493
41Interstitial pulmonary disease (HP:0006530)2.20190841
42Increased connective tissue (HP:0009025)2.18512959
43Nasal polyposis (HP:0100582)2.18326984
44High pitched voice (HP:0001620)2.16479597
45Genu recurvatum (HP:0002816)2.11022727
46Urethral obstruction (HP:0000796)2.10513837
47Bladder diverticulum (HP:0000015)2.09863898
48Dilatation of the ascending aorta (HP:0005111)2.09815992
49Spinal cord lesions (HP:0100561)2.09047825
50Syringomyelia (HP:0003396)2.09047825
51Lip pit (HP:0100267)2.08789534
52Metaphyseal cupping (HP:0003021)2.05784897
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.05376464
54Mitral valve prolapse (HP:0001634)2.05268620
55Renal duplication (HP:0000075)2.04226747
56Aneurysm (HP:0002617)2.04143095
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02234141
58Absent frontal sinuses (HP:0002688)2.00406075
59Abnormality of the distal phalanges of the toes (HP:0010182)1.99788265
60Curly hair (HP:0002212)1.99555533
61Osteolytic defects of the hand bones (HP:0009699)1.99225911
62Osteolytic defects of the phalanges of the hand (HP:0009771)1.99225911
63Malignant gastrointestinal tract tumors (HP:0006749)1.99209899
64Gastrointestinal carcinoma (HP:0002672)1.99209899
65Ulnar bowing (HP:0003031)1.96963688
66Ridged nail (HP:0001807)1.96938925
67Cutaneous melanoma (HP:0012056)1.96578168
68Rectal prolapse (HP:0002035)1.96462806
69Abnormality of the calcaneus (HP:0008364)1.96104756
70Aortic dissection (HP:0002647)1.95888021
71Wrist flexion contracture (HP:0001239)1.95671305
72Impulsivity (HP:0100710)1.94136440
73Abnormality of the nasal mucosa (HP:0000433)1.93955270
74Renovascular hypertension (HP:0100817)1.93914891
75Deviation of the thumb (HP:0009603)1.93891667
76Astrocytoma (HP:0009592)1.93088788
77Abnormality of the astrocytes (HP:0100707)1.93088788
78Recurrent bacterial skin infections (HP:0005406)1.92318072
79Absent eyelashes (HP:0000561)1.91560258
80Difficulty climbing stairs (HP:0003551)1.91420062
81Broad face (HP:0000283)1.89481798
82Heterotopia (HP:0002282)1.89428509
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.89359295
84Absent/shortened dynein arms (HP:0200106)1.89359295
85Bicuspid aortic valve (HP:0001647)1.87287952
86Increased density of long bones (HP:0006392)1.86551684
87Lymphangioma (HP:0100764)1.85756650
88Gingivitis (HP:0000230)1.85531248
89Degeneration of anterior horn cells (HP:0002398)1.85077432
90Abnormality of the anterior horn cell (HP:0006802)1.85077432
91Follicular hyperkeratosis (HP:0007502)1.84827549
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84515465
93Disproportionate tall stature (HP:0001519)1.83718376
94Ectopic kidney (HP:0000086)1.83000489
95Abnormal vertebral ossification (HP:0100569)1.81840500
96Autoimmune thrombocytopenia (HP:0001973)1.79892033
97Atrophic scars (HP:0001075)1.79840340
98Uterine leiomyosarcoma (HP:0002891)1.79586817
99Leiomyosarcoma (HP:0100243)1.79586817
100Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77968018
101Increased nuchal translucency (HP:0010880)1.77870507
102Hematochezia (HP:0002573)1.77122568
103Bowel diverticulosis (HP:0005222)1.76835217
104Abnormality of the fingertips (HP:0001211)1.76318220
105Periodontitis (HP:0000704)1.75590511
106Transitional cell carcinoma of the bladder (HP:0006740)1.74780165
107Flat acetabular roof (HP:0003180)1.73513313
108Abnormal blistering of the skin (HP:0008066)1.73259053
109Broad thumb (HP:0011304)1.72915196
110Pterygium (HP:0001059)1.72304010
111Ectropion (HP:0000656)1.71819625
112Proximal placement of thumb (HP:0009623)1.71475199
113Skull defect (HP:0001362)1.70333354
114Spinal muscular atrophy (HP:0007269)1.69753091
115Advanced eruption of teeth (HP:0006288)1.68395267
116Pelvic girdle muscle weakness (HP:0003749)1.67950376
117Short nail (HP:0001799)1.67914893
118Wormian bones (HP:0002645)1.67839674
119Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67493538
120Bladder carcinoma (HP:0002862)1.67020689
121Bladder neoplasm (HP:0009725)1.67020689
122Short humerus (HP:0005792)1.65655991
123Elfin facies (HP:0004428)1.65341415
124Popliteal pterygium (HP:0009756)1.65035960
125Persistence of primary teeth (HP:0006335)1.64043609
126Biliary tract neoplasm (HP:0100574)1.63188787
127Hypoplastic labia majora (HP:0000059)1.62240209
128Blue sclerae (HP:0000592)1.61530176
129Abnormality of the salivary glands (HP:0010286)1.61223931
130Abnormality of the frontal sinuses (HP:0002687)1.60832627
131Recurrent abscess formation (HP:0002722)1.60471025
132Broad phalanges of the hand (HP:0009768)1.60448446
133Chronic bronchitis (HP:0004469)1.59462679
134Asymmetry of the thorax (HP:0001555)1.58722239
135Long palpebral fissure (HP:0000637)1.58694582
136Long eyelashes (HP:0000527)1.58067677
137Deviation of the hallux (HP:0010051)1.57320023
138Renal cell carcinoma (HP:0005584)1.56549053
139Abnormality of the acetabulum (HP:0003170)1.56476779
140Blepharitis (HP:0000498)1.56322245
141Long toe (HP:0010511)1.56002929
142Abnormality of the peritoneum (HP:0002585)1.55798983
143Micronodular cirrhosis (HP:0001413)1.55704163
144Joint laxity (HP:0001388)1.55581643
145Hallux valgus (HP:0001822)1.55511749
146Agnosia (HP:0010524)1.55031604
147Severe short stature (HP:0003510)1.55024979
148Arnold-Chiari malformation (HP:0002308)1.53535797
149Hypoplasia of dental enamel (HP:0006297)1.52747022
150Short phalanx of the thumb (HP:0009660)1.52365591
151Abnormality of the hip-girdle musculature (HP:0001445)1.51801063
152Abnormality of the musculature of the pelvis (HP:0001469)1.51801063
153Neonatal short-limb short stature (HP:0008921)1.51631546
154Uterine neoplasm (HP:0010784)1.50947120
155Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.50668564
156Vertebral hypoplasia (HP:0008417)1.50668564
157Vertebral clefting (HP:0008428)1.48624196
158Mesangial abnormality (HP:0001966)1.48217990
159Thin bony cortex (HP:0002753)1.47292320
160Deep philtrum (HP:0002002)1.47137280
161Broad palm (HP:0001169)1.46760224
162Sandal gap (HP:0001852)1.46642328
163Missing ribs (HP:0000921)1.46355806
164Aplasia/hypoplasia of the humerus (HP:0006507)1.44559293
165Truncal obesity (HP:0001956)1.44157499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.71398237
2TESK13.18592076
3PKN22.90474288
4CDK122.79783935
5EEF2K2.75865727
6MAP3K22.70716201
7MAP3K122.62408271
8EPHB12.59429439
9NEK22.56717737
10MAP3K102.47507196
11PDK32.39172073
12PDK42.39172073
13EPHA22.32691494
14TTN2.22079538
15ICK2.13939297
16MAP3K62.00554108
17LATS11.98806615
18STK241.96358657
19KSR21.91865758
20KSR11.89390148
21PAK41.87222692
22PTK61.84174085
23YES11.72750898
24CDC71.62911057
25TTK1.62339537
26RIPK11.57361738
27STK31.55031431
28STK101.52519036
29PRKD31.50718532
30PDK21.48757679
31PDGFRA1.44561688
32CSK1.39509209
33IRAK11.39209034
34RPS6KA41.36546019
35ERN11.36332482
36SCYL21.36045358
37IRAK21.35497812
38MTOR1.34050819
39ERBB41.33457393
40RPS6KB21.32887937
41WEE11.29658987
42NEK11.29607635
43IRAK41.26312664
44BMX1.26269396
45FER1.25086491
46CDK41.25071855
47IRAK31.23571466
48CDK61.21767470
49FGR1.20126384
50PBK1.19450188
51TSSK61.18721199
52NTRK11.16147105
53CAMK1D1.13428175
54MAP2K31.10368851
55LRRK21.09685575
56SMG11.08464587
57MAP3K11.07071851
58MAP3K81.05743447
59TGFBR11.04487663
60BRD41.02007882
61PAK21.00615407
62ATR0.98652397
63RET0.98043190
64MOS0.95419782
65TESK20.94788362
66NEK90.94291586
67CDK70.93733162
68PTK2B0.90287480
69MET0.89256383
70BLK0.88969266
71BUB10.87692688
72WNK10.87029399
73PRPF4B0.85734427
74PTK20.84659294
75CHEK10.81172755
76DDR20.80884528
77BCR0.80726843
78MAP3K140.79439343
79FGFR10.79207422
80PASK0.78855895
81PIM10.78552519
82TAOK10.78206401
83AURKB0.78097872
84STK40.77647965
85CLK10.77124729
86PLK10.74398079
87MAP3K30.74003742
88RAF10.73338237
89STK38L0.71902587
90MAP2K40.70304156
91CAMK1G0.68956404
92ERBB30.68502930
93EPHA30.68311191
94TYRO30.68172900
95LATS20.66726296
96JAK30.66547917
97ROCK20.65758666
98DYRK1B0.65070746
99CHEK20.64654411
100ALK0.63970009
101CHUK0.63547179
102FLT30.61232716
103TGFBR20.61145774
104FGFR40.58015049
105PDGFRB0.57943530
106MST1R0.57450721
107MYLK0.56515782
108ATM0.56252325
109EPHB20.54336664
110CSF1R0.53804344
111SIK10.52998911
112SGK30.52225593
113ILK0.51742038
114PAK10.50852418
115FGFR30.50484066
116MAP3K90.50209606
117CDK20.50180691
118TRPM70.49899001
119DMPK0.48674669
120TYK20.48439181
121MARK30.47203261
122MELK0.47199595
123MAP4K10.46746386
124RPS6KA20.46655831
125STK380.44372532
126MAP3K130.44090631
127BRSK20.43680327
128ZAP700.43187401
129MARK20.42601591
130MAPKAPK30.41413564
131EGFR0.41375319
132PRKG20.37880358
133CDK90.36648126
134PRKD20.36447842
135RPS6KA10.36349269
136DYRK30.36049429
137ZAK0.35793133
138PLK30.35753754
139HCK0.35494967
140ACVR1B0.35165509
141TAOK20.34992997
142AKT30.34740748
143BRAF0.34413972
144SRPK10.34299389

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.05816458
2DNA replication_Homo sapiens_hsa030301.96674814
3Cell cycle_Homo sapiens_hsa041101.88870207
4One carbon pool by folate_Homo sapiens_hsa006701.86655375
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86405704
6Small cell lung cancer_Homo sapiens_hsa052221.86263867
7Renal cell carcinoma_Homo sapiens_hsa052111.82106673
8Adherens junction_Homo sapiens_hsa045201.74616017
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71412930
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67831524
11Chronic myeloid leukemia_Homo sapiens_hsa052201.63602573
12mRNA surveillance pathway_Homo sapiens_hsa030151.51136904
13MicroRNAs in cancer_Homo sapiens_hsa052061.50152695
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47602606
15ErbB signaling pathway_Homo sapiens_hsa040121.38577277
16Spliceosome_Homo sapiens_hsa030401.38401312
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.37836492
18Proteoglycans in cancer_Homo sapiens_hsa052051.34609976
19Legionellosis_Homo sapiens_hsa051341.33940786
20Mismatch repair_Homo sapiens_hsa034301.33704116
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32540024
22Base excision repair_Homo sapiens_hsa034101.31745788
23Viral carcinogenesis_Homo sapiens_hsa052031.30523810
24Antigen processing and presentation_Homo sapiens_hsa046121.29840964
25p53 signaling pathway_Homo sapiens_hsa041151.28403475
26Lysine degradation_Homo sapiens_hsa003101.27721259
27Selenocompound metabolism_Homo sapiens_hsa004501.27311853
28Viral myocarditis_Homo sapiens_hsa054161.23257602
29Focal adhesion_Homo sapiens_hsa045101.23204456
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18368153
31Hippo signaling pathway_Homo sapiens_hsa043901.18062428
32Bladder cancer_Homo sapiens_hsa052191.18043387
33Toxoplasmosis_Homo sapiens_hsa051451.15968449
34HTLV-I infection_Homo sapiens_hsa051661.15364838
35Hepatitis C_Homo sapiens_hsa051601.12473296
36Fructose and mannose metabolism_Homo sapiens_hsa000511.12243648
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.12037008
38mTOR signaling pathway_Homo sapiens_hsa041501.11999689
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10592364
40Malaria_Homo sapiens_hsa051441.09659949
41Notch signaling pathway_Homo sapiens_hsa043301.08436770
42HIF-1 signaling pathway_Homo sapiens_hsa040661.05040696
43Dorso-ventral axis formation_Homo sapiens_hsa043201.03469559
44TGF-beta signaling pathway_Homo sapiens_hsa043501.02053080
45ECM-receptor interaction_Homo sapiens_hsa045121.01967133
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01393722
47Basal cell carcinoma_Homo sapiens_hsa052171.00932239
48Epstein-Barr virus infection_Homo sapiens_hsa051691.00588908
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99426226
50Colorectal cancer_Homo sapiens_hsa052100.98079120
51Prolactin signaling pathway_Homo sapiens_hsa049170.97927543
52Apoptosis_Homo sapiens_hsa042100.97636490
53Shigellosis_Homo sapiens_hsa051310.97369370
54Axon guidance_Homo sapiens_hsa043600.97319276
55Endometrial cancer_Homo sapiens_hsa052130.97161070
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.96667071
57Pancreatic cancer_Homo sapiens_hsa052120.95858517
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95545509
59Herpes simplex infection_Homo sapiens_hsa051680.94626047
60Acute myeloid leukemia_Homo sapiens_hsa052210.93958385
61Influenza A_Homo sapiens_hsa051640.93706595
62Fanconi anemia pathway_Homo sapiens_hsa034600.93648287
63FoxO signaling pathway_Homo sapiens_hsa040680.93219241
64Inositol phosphate metabolism_Homo sapiens_hsa005620.92683141
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92640168
66Pentose phosphate pathway_Homo sapiens_hsa000300.92420384
67Endocytosis_Homo sapiens_hsa041440.92317708
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91904574
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.91136220
70Renin-angiotensin system_Homo sapiens_hsa046140.90160197
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89730101
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89523398
73Prostate cancer_Homo sapiens_hsa052150.89098925
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88323663
75Choline metabolism in cancer_Homo sapiens_hsa052310.87741421
76Hedgehog signaling pathway_Homo sapiens_hsa043400.84669135
77Biosynthesis of amino acids_Homo sapiens_hsa012300.84572855
78Rap1 signaling pathway_Homo sapiens_hsa040150.84375430
79Hepatitis B_Homo sapiens_hsa051610.84146699
80GnRH signaling pathway_Homo sapiens_hsa049120.83510118
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83113248
82Amoebiasis_Homo sapiens_hsa051460.82919154
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82766827
84Phagosome_Homo sapiens_hsa041450.82167934
85Carbon metabolism_Homo sapiens_hsa012000.81434235
86Leishmaniasis_Homo sapiens_hsa051400.81110919
87Thyroid cancer_Homo sapiens_hsa052160.81011545
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80963992
89Non-small cell lung cancer_Homo sapiens_hsa052230.79540102
90Platelet activation_Homo sapiens_hsa046110.79387319
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79061320
92Tuberculosis_Homo sapiens_hsa051520.77619801
93Measles_Homo sapiens_hsa051620.77431186
94Insulin resistance_Homo sapiens_hsa049310.77286178
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76928177
96Galactose metabolism_Homo sapiens_hsa000520.76687011
97Tight junction_Homo sapiens_hsa045300.75227202
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75110943
99B cell receptor signaling pathway_Homo sapiens_hsa046620.75021278
100Estrogen signaling pathway_Homo sapiens_hsa049150.74780158
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.74701961
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73972788
103Gap junction_Homo sapiens_hsa045400.72917073
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72409102
105Insulin signaling pathway_Homo sapiens_hsa049100.72230114
106Pathways in cancer_Homo sapiens_hsa052000.71544946
107TNF signaling pathway_Homo sapiens_hsa046680.70535785
108Osteoclast differentiation_Homo sapiens_hsa043800.70424721
109Nucleotide excision repair_Homo sapiens_hsa034200.70340537
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70162196
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69764243
112Chemokine signaling pathway_Homo sapiens_hsa040620.67468493
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.66200728
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66058851
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65495458
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63733565
117RNA degradation_Homo sapiens_hsa030180.63712879
118AMPK signaling pathway_Homo sapiens_hsa041520.63669571
119Sphingolipid metabolism_Homo sapiens_hsa006000.63448644
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62534213
121Wnt signaling pathway_Homo sapiens_hsa043100.62493150
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.62218038
123Salmonella infection_Homo sapiens_hsa051320.61955034
124Fat digestion and absorption_Homo sapiens_hsa049750.61310368
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59445908
126Systemic lupus erythematosus_Homo sapiens_hsa053220.58229338
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.58180259
128Pertussis_Homo sapiens_hsa051330.57712517
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57501827
130Glucagon signaling pathway_Homo sapiens_hsa049220.57338796
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57289277
132Glioma_Homo sapiens_hsa052140.55895951
133Oocyte meiosis_Homo sapiens_hsa041140.53894859
134Melanoma_Homo sapiens_hsa052180.53650041
135Fatty acid biosynthesis_Homo sapiens_hsa000610.53590118
136VEGF signaling pathway_Homo sapiens_hsa043700.51743790
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51598399
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51359086

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