PPP4R1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.53663482
2modulation by symbiont of host defense response (GO:0052031)5.53663482
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53663482
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53663482
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.53663482
6modulation by symbiont of host immune response (GO:0052553)5.53663482
7positive regulation of gamma-delta T cell activation (GO:0046645)5.33443784
8detection of molecule of bacterial origin (GO:0032490)5.22878299
9response to peptidoglycan (GO:0032494)5.06148800
10macrophage activation involved in immune response (GO:0002281)4.96856765
11neutrophil activation involved in immune response (GO:0002283)4.80540253
12negative regulation of interleukin-12 production (GO:0032695)4.71911921
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.63316014
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46977482
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.35353390
16negative regulation of cell killing (GO:0031342)4.35353390
17cellular extravasation (GO:0045123)4.32285151
18detection of other organism (GO:0098543)4.30846165
19detection of external biotic stimulus (GO:0098581)4.25471614
20regulation of interferon-beta biosynthetic process (GO:0045357)4.01120310
21regulation of B cell receptor signaling pathway (GO:0050855)3.95595105
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93194577
23myeloid cell activation involved in immune response (GO:0002275)3.92479482
24regulation of T-helper 2 cell differentiation (GO:0045628)3.86120889
25detection of bacterium (GO:0016045)3.84968774
26detection of biotic stimulus (GO:0009595)3.82752071
27regulation of gamma-delta T cell activation (GO:0046643)3.75633690
28neutrophil activation (GO:0042119)3.75019089
29microglial cell activation (GO:0001774)3.66089204
30granulocyte activation (GO:0036230)3.61884047
31macrophage activation (GO:0042116)3.58707216
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.57185807
33negative regulation of T-helper cell differentiation (GO:0045623)3.57185807
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56230946
35response to host immune response (GO:0052572)3.56230946
36leukocyte aggregation (GO:0070486)3.56117124
37response to muramyl dipeptide (GO:0032495)3.51627403
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.49877946
39response to host (GO:0075136)3.49877946
40response to host defenses (GO:0052200)3.49877946
41antigen processing and presentation of endogenous antigen (GO:0019883)3.48546343
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47430619
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.41778869
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41307749
45respiratory burst (GO:0045730)3.39201314
46germinal center formation (GO:0002467)3.39078283
47leukocyte degranulation (GO:0043299)3.35608076
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30039067
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.26021013
50immunoglobulin mediated immune response (GO:0016064)3.25733396
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23472079
52positive regulation of B cell differentiation (GO:0045579)3.22962368
53regulation of T-helper 1 cell differentiation (GO:0045625)3.21122781
54T-helper 1 type immune response (GO:0042088)3.20325155
55positive regulation of mast cell activation (GO:0033005)3.20008973
56production of molecular mediator involved in inflammatory response (GO:0002532)3.14846176
57regulation of alpha-beta T cell proliferation (GO:0046640)3.14009188
58defense response to protozoan (GO:0042832)3.13989195
59regulation of B cell differentiation (GO:0045577)3.13401867
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.13097241
61negative regulation of interleukin-1 beta production (GO:0032691)3.11805076
62cellular response to type I interferon (GO:0071357)3.11538836
63type I interferon signaling pathway (GO:0060337)3.11538836
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10558597
65response to type I interferon (GO:0034340)3.08766433
66neutrophil mediated immunity (GO:0002446)3.06027313
67negative regulation of cytokine production involved in immune response (GO:0002719)3.03688237
68negative regulation of interleukin-1 production (GO:0032692)3.02714243
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01957763
70regulation of gamma-delta T cell differentiation (GO:0045586)3.01303597
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00363563
72negative regulation of lymphocyte mediated immunity (GO:0002707)2.97457288
73positive regulation of interferon-alpha production (GO:0032727)2.93752186
74positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91968171
75positive regulation of mast cell activation involved in immune response (GO:0033008)2.91924087
76positive regulation of mast cell degranulation (GO:0043306)2.91924087
77regulation of mast cell degranulation (GO:0043304)2.91663465
78regulation of mast cell activation (GO:0033003)2.91047262
79B cell receptor signaling pathway (GO:0050853)2.90276917
80interferon-gamma-mediated signaling pathway (GO:0060333)2.89913044
81negative regulation of T cell mediated immunity (GO:0002710)2.89604313
82positive regulation of interleukin-17 production (GO:0032740)2.89370151
83response to interleukin-15 (GO:0070672)2.89360807
84regulation of T cell tolerance induction (GO:0002664)2.89185546
85myeloid leukocyte activation (GO:0002274)2.88580637
86regulation of interferon-alpha production (GO:0032647)2.87582724
87positive regulation of interferon-beta production (GO:0032728)2.87000732
88positive regulation of type 2 immune response (GO:0002830)2.86919326
89regulation of tolerance induction (GO:0002643)2.86484805
90leukocyte migration involved in inflammatory response (GO:0002523)2.84579814
91NIK/NF-kappaB signaling (GO:0038061)2.84205875
92negative regulation of alpha-beta T cell activation (GO:0046636)2.82008514
93mast cell activation (GO:0045576)2.81619414
94regulation of interleukin-8 biosynthetic process (GO:0045414)2.80554530
95response to protozoan (GO:0001562)2.80370621
96regulation of mast cell activation involved in immune response (GO:0033006)2.79444400
97tolerance induction (GO:0002507)2.78631154
98negative regulation of type 2 immune response (GO:0002829)2.76391592
99interferon-gamma production (GO:0032609)2.74632673
100negative regulation of interleukin-6 production (GO:0032715)2.74442537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.12971175
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.02059921
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.53388943
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.15922124
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.15737663
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57512520
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.49714108
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.22685932
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21946975
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17484058
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.08412972
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01965161
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.93600361
14RUNX_20019798_ChIP-Seq_JUKART_Human2.60959955
15SPI1_23547873_ChIP-Seq_NB4_Human2.57527176
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55751096
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.55625128
18SPI1_23127762_ChIP-Seq_K562_Human2.54419020
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49044490
20VDR_24787735_ChIP-Seq_THP-1_Human2.45917599
21* MYB_26560356_Chip-Seq_TH2_Human2.44366062
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.29220775
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21479390
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20459811
25MYB_26560356_Chip-Seq_TH1_Human2.19760732
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19630682
27SCL_19346495_ChIP-Seq_HPC-7_Human2.12497352
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11387995
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04639223
30MAF_26560356_Chip-Seq_TH1_Human2.02276093
31VDR_24763502_ChIP-Seq_THP-1_Human1.93252075
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91493995
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89891131
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79398109
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76891802
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64421245
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.63116999
38GATA3_26560356_Chip-Seq_TH2_Human1.59625422
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59092747
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52572107
41GATA3_27048872_Chip-Seq_THYMUS_Human1.51712393
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51708602
43PU_27001747_Chip-Seq_BMDM_Mouse1.49262785
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43300168
45GATA1_22025678_ChIP-Seq_K562_Human1.42431460
46* UTX_26944678_Chip-Seq_JUKART_Human1.42429384
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41653865
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40150275
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39867315
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36745709
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35194214
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34844907
53* MAF_26560356_Chip-Seq_TH2_Human1.29849170
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25896239
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25137456
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24186059
57VDR_21846776_ChIP-Seq_THP-1_Human1.20655361
58MYC_22102868_ChIP-Seq_BL_Human1.20288782
59TCF7_22412390_ChIP-Seq_EML_Mouse1.18346597
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.17132171
61NCOR1_26117541_ChIP-Seq_K562_Human1.13913685
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12019602
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10739151
64TFEB_21752829_ChIP-Seq_HELA_Human1.09370901
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08206912
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05610625
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04101415
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04008289
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98453127
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95003143
71GATA2_19941826_ChIP-Seq_K562_Human0.94540495
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93756686
73HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92767983
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92067389
75GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91543085
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91469220
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91469220
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91469220
79SMRT_27268052_Chip-Seq_Bcells_Human0.90876357
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89794128
81ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89608855
82GATA1_19941826_ChIP-Seq_K562_Human0.89074187
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88410895
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.87069583
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.86289054
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84993827
87KDM2B_26808549_Chip-Seq_DND41_Human0.84627406
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83563498
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83499302
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.82683982
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82406562
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82334279
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82132060
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82132060
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81189088
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79541071
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78331088
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76112275
99* BRD4_25478319_ChIP-Seq_HGPS_Human0.75444976
100ER_23166858_ChIP-Seq_MCF-7_Human0.75344610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.26324867
2MP0003436_decreased_susceptibility_to3.59987354
3MP0001835_abnormal_antigen_presentation3.49459400
4MP0003303_peritoneal_inflammation3.43282474
5MP0002419_abnormal_innate_immunity2.90158138
6MP0009785_altered_susceptibility_to2.86107475
7MP0001800_abnormal_humoral_immune2.79416547
8MP0005451_abnormal_body_composition2.78251572
9MP0005000_abnormal_immune_tolerance2.58950170
10MP0002452_abnormal_antigen_presenting2.48343659
11MP0001790_abnormal_immune_system2.46970230
12MP0005387_immune_system_phenotype2.46970230
13MP0002723_abnormal_immune_serum2.46556776
14MP0002148_abnormal_hypersensitivity_rea2.41773371
15MP0005025_abnormal_response_to2.40110902
16MP0005671_abnormal_response_to2.39238239
17MP0000685_abnormal_immune_system2.32977128
18MP0009278_abnormal_bone_marrow2.28440045
19MP0002132_abnormal_respiratory_system2.28034913
20MP0003300_gastrointestinal_ulcer2.22668004
21MP0002420_abnormal_adaptive_immunity2.22165278
22MP0001819_abnormal_immune_cell2.20420361
23MP0003191_abnormal_cellular_cholesterol2.19256405
24MP0006082_CNS_inflammation2.16360513
25MP0003828_pulmonary_edema2.14826978
26MP0008260_abnormal_autophagy2.01592557
27MP0002405_respiratory_system_inflammati1.99516939
28MP0006054_spinal_hemorrhage1.99195948
29MP0001545_abnormal_hematopoietic_system1.90172807
30MP0005397_hematopoietic_system_phenotyp1.90172807
31MP0003763_abnormal_thymus_physiology1.81468873
32MP0009764_decreased_sensitivity_to1.80916178
33MP0004947_skin_inflammation1.79599757
34MP0001853_heart_inflammation1.78334626
35MP0002398_abnormal_bone_marrow1.75358512
36MP0001533_abnormal_skeleton_physiology1.74130849
37MP0000716_abnormal_immune_system1.70559352
38MP0005464_abnormal_platelet_physiology1.70137064
39MP0001845_abnormal_inflammatory_respons1.63301644
40MP0010155_abnormal_intestine_physiology1.55224891
41MP0003195_calcinosis1.51093152
42MP0000858_altered_metastatic_potential1.50740738
43MP0000689_abnormal_spleen_morphology1.49589051
44MP0004883_abnormal_blood_vessel1.46247696
45MP0009333_abnormal_splenocyte_physiolog1.44555438
46MP0002722_abnormal_immune_system1.43983613
47MP0004510_myositis1.42874029
48MP0008057_abnormal_DNA_replication1.39471673
49MP0002429_abnormal_blood_cell1.35873398
50MP0008004_abnormal_stomach_pH1.34848478
51MP0000703_abnormal_thymus_morphology1.31899320
52MP0005164_abnormal_response_to1.30312831
53MP0008469_abnormal_protein_level1.30117764
54MP0002998_abnormal_bone_remodeling1.28897780
55MP0003656_abnormal_erythrocyte_physiolo1.21443776
56MP0005310_abnormal_salivary_gland1.18195754
57MP0002166_altered_tumor_susceptibility1.16468351
58MP0003091_abnormal_cell_migration1.15643631
59MP0005058_abnormal_lysosome_morphology1.14503542
60MP0004381_abnormal_hair_follicle1.14124070
61MP0001873_stomach_inflammation1.13294558
62MP0002332_abnormal_exercise_endurance1.12645554
63MP0002277_abnormal_respiratory_mucosa1.10287202
64MP0003221_abnormal_cardiomyocyte_apopto1.09967135
65MP0005076_abnormal_cell_differentiation1.08855800
66MP0000343_altered_response_to1.07830087
67MP0002006_tumorigenesis1.07343311
68MP0002396_abnormal_hematopoietic_system1.06873847
69MP0002254_reproductive_system_inflammat1.05513531
70MP0000465_gastrointestinal_hemorrhage1.04147879
71MP0003448_altered_tumor_morphology1.03002297
72MP0004808_abnormal_hematopoietic_stem1.02076142
73MP0002138_abnormal_hepatobiliary_system0.97172381
74MP0003172_abnormal_lysosome_physiology0.92857484
75MP0001851_eye_inflammation0.92726821
76MP0000372_irregular_coat_pigmentation0.88481822
77MP0009765_abnormal_xenobiotic_induced0.85847065
78MP0009763_increased_sensitivity_to0.85234647
79MP0005410_abnormal_fertilization0.83654995
80MP0002009_preneoplasia0.83038276
81MP0000569_abnormal_digit_pigmentation0.81831853
82MP0005390_skeleton_phenotype0.78907339
83MP0003866_abnormal_defecation0.77808623
84MP0003075_altered_response_to0.75981660
85MP0005166_decreased_susceptibility_to0.75167290
86MP0001915_intracranial_hemorrhage0.73614593
87MP0000371_diluted_coat_color0.73169473
88MP0000249_abnormal_blood_vessel0.71986773
89MP0003950_abnormal_plasma_membrane0.70626985
90MP0003453_abnormal_keratinocyte_physiol0.70359576
91MP0001663_abnormal_digestive_system0.69889604
92MP0000015_abnormal_ear_pigmentation0.66233819
93MP0009115_abnormal_fat_cell0.63639794
94MP0003795_abnormal_bone_structure0.62458178
95MP0005621_abnormal_cell_physiology0.62410489
96MP0010386_abnormal_urinary_bladder0.61514226
97MP0005023_abnormal_wound_healing0.61006790
98MP0005075_abnormal_melanosome_morpholog0.60302245
99MP0002933_joint_inflammation0.59240494
100MP0000604_amyloidosis0.57161479

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.85684443
2Recurrent abscess formation (HP:0002722)5.55579045
3Eczematoid dermatitis (HP:0000976)5.30940806
4Retrobulbar optic neuritis (HP:0100654)5.06133290
5Optic neuritis (HP:0100653)5.06133290
6Orchitis (HP:0100796)4.96960233
7Myositis (HP:0100614)4.92628439
8Abnormality of macrophages (HP:0004311)4.86616117
9Elevated erythrocyte sedimentation rate (HP:0003565)4.42830768
10Stomatitis (HP:0010280)4.35374390
11Recurrent fungal infections (HP:0002841)3.92472420
12T lymphocytopenia (HP:0005403)3.77872714
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.73926400
14Keratoconjunctivitis sicca (HP:0001097)3.64217454
15Abnormality of T cell number (HP:0011839)3.61969446
16Gastrointestinal infarctions (HP:0005244)3.59322323
17Panhypogammaglobulinemia (HP:0003139)3.56146829
18Recurrent skin infections (HP:0001581)3.50826312
19Mediastinal lymphadenopathy (HP:0100721)3.44098663
20Encephalitis (HP:0002383)3.35170613
21Recurrent gram-negative bacterial infections (HP:0005420)3.33303052
22Meningitis (HP:0001287)3.27621105
23Obstructive lung disease (HP:0006536)3.25493830
24Chronic obstructive pulmonary disease (HP:0006510)3.25493830
25Keratoconjunctivitis (HP:0001096)3.24966081
26Recurrent viral infections (HP:0004429)3.24591454
27Spontaneous hematomas (HP:0007420)3.12596350
28Vasculitis (HP:0002633)3.07247295
29Chronic mucocutaneous candidiasis (HP:0002728)2.97909867
30Recurrent cutaneous fungal infections (HP:0011370)2.97909867
31Peritonitis (HP:0002586)2.92510574
32Leukocytosis (HP:0001974)2.87257751
33Gingivitis (HP:0000230)2.80812486
34Segmental peripheral demyelination/remyelination (HP:0003481)2.76160146
35Abnormality of T cells (HP:0002843)2.72401640
36Increased IgE level (HP:0003212)2.65225879
37Pustule (HP:0200039)2.60504319
38Granulocytopenia (HP:0001913)2.59840366
39Amyloidosis (HP:0011034)2.57019572
40Eosinophilia (HP:0001880)2.44059925
41Cellulitis (HP:0100658)2.42310726
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41622238
43Abnormality of the fingertips (HP:0001211)2.40851753
44Urticaria (HP:0001025)2.40258410
45Keratitis (HP:0000491)2.40209217
46Hemoptysis (HP:0002105)2.39425035
47Neoplasm of the tracheobronchial system (HP:0100552)2.34671934
48Pulmonary infiltrates (HP:0002113)2.33446113
49Anorexia (HP:0002039)2.32255846
50Arterial thrombosis (HP:0004420)2.31946000
51Alveolar cell carcinoma (HP:0006519)2.31620540
52Osteomyelitis (HP:0002754)2.31020675
53Viral hepatitis (HP:0006562)2.30386537
54Disinhibition (HP:0000734)2.27115101
55Lymphopenia (HP:0001888)2.26862299
56Chest pain (HP:0100749)2.26337129
57Gangrene (HP:0100758)2.20560982
58Vacuolated lymphocytes (HP:0001922)2.18637471
59Fatigue (HP:0012378)2.17891129
60Premature loss of primary teeth (HP:0006323)2.16136814
61Increased IgM level (HP:0003496)2.15470463
62Subacute progressive viral hepatitis (HP:0006572)2.15351710
63Abnormality of B cell number (HP:0010975)2.12709882
64Episodic fever (HP:0001954)2.11808611
65Colitis (HP:0002583)2.11412674
66Prolonged bleeding time (HP:0003010)2.10765828
67Abnormality of T cell physiology (HP:0011840)2.10247835
68Hypochromic microcytic anemia (HP:0004840)2.09814048
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.07693799
70Aplasia/Hypoplasia of the thymus (HP:0010515)2.02677054
71Inflammation of the large intestine (HP:0002037)2.02459701
72Hypertensive crisis (HP:0100735)2.01322143
73Abnormality of the peritoneum (HP:0002585)2.00545513
74Spondylolisthesis (HP:0003302)1.99460480
75Autoimmune hemolytic anemia (HP:0001890)1.96367108
76B lymphocytopenia (HP:0010976)1.95373858
77Autoimmune thrombocytopenia (HP:0001973)1.94762937
78Epistaxis (HP:0000421)1.94658043
79IgM deficiency (HP:0002850)1.94147339
80Amaurosis fugax (HP:0100576)1.90471745
81Petechiae (HP:0000967)1.89103217
82Abnormality of the endocardium (HP:0004306)1.88727024
83Acute hepatic failure (HP:0006554)1.87394720
84Increased serum ferritin (HP:0003281)1.87247231
85Abnormality of the thymus (HP:0000777)1.87131503
86Recurrent pneumonia (HP:0006532)1.86234445
87Gastrointestinal inflammation (HP:0004386)1.86081779
88Syringomyelia (HP:0003396)1.85655250
89Spinal cord lesions (HP:0100561)1.85655250
90Polycythemia (HP:0001901)1.83875386
91Parakeratosis (HP:0001036)1.82209134
92Glomerulopathy (HP:0100820)1.82057558
93Sepsis (HP:0100806)1.81966450
94Hematochezia (HP:0002573)1.81726153
95Polyneuropathy (HP:0001271)1.81391357
96Chronic otitis media (HP:0000389)1.80780256
97Albinism (HP:0001022)1.80263552
98Gingival bleeding (HP:0000225)1.79527941
99Acne (HP:0001061)1.77968647
100Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77165157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.77469584
2IRAK43.42543815
3TYK22.84712713
4BLK2.73000760
5CSK2.66482812
6MAP4K12.60577654
7MAP3K142.59905040
8EPHB12.59299086
9MAP2K32.09048746
10BMPR22.05709922
11IRAK12.03799871
12SIK31.97170600
13MAP3K121.96143195
14IKBKE1.90378644
15JAK31.84790011
16PRPF4B1.84681635
17AKT31.80071164
18PIK3CG1.77833742
19MAP3K31.68527404
20TAOK31.67875179
21BTK1.60815262
22MAP3K131.59037538
23IRAK31.57835194
24FES1.57262748
25MARK31.52628907
26HCK1.52474433
27ZAP701.51739109
28FGR1.48586930
29CDK121.47006092
30PDK21.46881424
31TGFBR21.45372206
32JAK11.39712633
33IKBKB1.35623139
34IRAK21.34925734
35DYRK31.32787023
36TXK1.32450707
37STK101.26147014
38ITK1.23191512
39JAK21.23153987
40NLK1.20934808
41YES11.19107020
42SYK1.18938881
43TBK11.18872172
44TAOK11.16376034
45MST41.13882251
46MOS1.13559140
47MAP3K11.13422173
48TEC1.11736888
49CSF1R1.09479268
50TNK21.06198942
51LYN1.04972574
52PLK41.04850365
53BRD41.02613105
54MATK1.01872556
55LCK1.00140870
56GRK60.98789875
57KSR20.95029372
58CLK10.91783010
59PTK2B0.88675764
60CHUK0.85179272
61ERN10.79252074
62TAOK20.77794016
63GRK70.76674888
64MELK0.75184556
65MAPK70.74568226
66KIT0.74495890
67PTK60.74433700
68WNK10.72036076
69FGFR30.71267664
70NME20.68914497
71MAP3K20.67373883
72PAK40.66748685
73ACVR1B0.65780577
74SGK20.64535874
75KSR10.64395405
76PDGFRB0.58736304
77MAP3K50.57206826
78SGK30.53579400
79STK40.53107235
80SIK20.52581655
81CDK190.51908455
82FGFR40.51789584
83TNIK0.50616541
84TRPM70.50611064
85PIM10.49839779
86PDK10.49558323
87DYRK1B0.49497494
88LRRK20.49495445
89MAP3K60.48052812
90EPHA30.47762473
91MARK20.46863806
92BMX0.44559155
93CDK40.42531188
94MAP3K110.42152177
95WNK30.42031082
96PRKCQ0.41536157
97EGFR0.41238254
98CDC42BPA0.40084593
99NEK90.39804593
100BRAF0.38773324

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.75079975
2Leishmaniasis_Homo sapiens_hsa051402.73247222
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.37075988
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30282722
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.24183612
6Graft-versus-host disease_Homo sapiens_hsa053322.21207585
7Allograft rejection_Homo sapiens_hsa053302.16041625
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15773500
9Staphylococcus aureus infection_Homo sapiens_hsa051502.15645133
10Malaria_Homo sapiens_hsa051442.06465131
11Tuberculosis_Homo sapiens_hsa051522.05599562
12B cell receptor signaling pathway_Homo sapiens_hsa046622.05581510
13Legionellosis_Homo sapiens_hsa051342.02239603
14Autoimmune thyroid disease_Homo sapiens_hsa053201.93657491
15Measles_Homo sapiens_hsa051621.92267541
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85619710
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85575657
18Influenza A_Homo sapiens_hsa051641.74126427
19TNF signaling pathway_Homo sapiens_hsa046681.73985105
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72350919
21Primary immunodeficiency_Homo sapiens_hsa053401.70705149
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.69342552
23Toxoplasmosis_Homo sapiens_hsa051451.64156399
24Acute myeloid leukemia_Homo sapiens_hsa052211.63455442
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59445383
26Hematopoietic cell lineage_Homo sapiens_hsa046401.55924878
27Other glycan degradation_Homo sapiens_hsa005111.55627551
28T cell receptor signaling pathway_Homo sapiens_hsa046601.53255228
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47303565
30Herpes simplex infection_Homo sapiens_hsa051681.45927330
31Asthma_Homo sapiens_hsa053101.43981099
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.43667963
33Chemokine signaling pathway_Homo sapiens_hsa040621.42121692
34Hepatitis B_Homo sapiens_hsa051611.41427560
35Viral myocarditis_Homo sapiens_hsa054161.36644249
36Rheumatoid arthritis_Homo sapiens_hsa053231.35659676
37Antigen processing and presentation_Homo sapiens_hsa046121.32514013
38African trypanosomiasis_Homo sapiens_hsa051431.31290455
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28568906
40Pancreatic cancer_Homo sapiens_hsa052121.26271936
41Type I diabetes mellitus_Homo sapiens_hsa049401.22372203
42Non-small cell lung cancer_Homo sapiens_hsa052231.17813170
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16825320
44Dorso-ventral axis formation_Homo sapiens_hsa043201.16697157
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15821882
46Renal cell carcinoma_Homo sapiens_hsa052111.15425807
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13115443
48Chronic myeloid leukemia_Homo sapiens_hsa052201.10108064
49FoxO signaling pathway_Homo sapiens_hsa040681.09890139
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09015120
51Apoptosis_Homo sapiens_hsa042101.08426897
52Phagosome_Homo sapiens_hsa041451.06973446
53Pertussis_Homo sapiens_hsa051331.03335376
54Hepatitis C_Homo sapiens_hsa051601.00774768
55Salmonella infection_Homo sapiens_hsa051320.98969085
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.98543150
57Platelet activation_Homo sapiens_hsa046110.95693379
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92904614
59Shigellosis_Homo sapiens_hsa051310.92027242
60Epstein-Barr virus infection_Homo sapiens_hsa051690.91587380
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89824298
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86218744
63Prolactin signaling pathway_Homo sapiens_hsa049170.84608108
64VEGF signaling pathway_Homo sapiens_hsa043700.83206293
65Inositol phosphate metabolism_Homo sapiens_hsa005620.78169378
66Colorectal cancer_Homo sapiens_hsa052100.77977061
67Lysosome_Homo sapiens_hsa041420.77045215
68HIF-1 signaling pathway_Homo sapiens_hsa040660.75957541
69Endometrial cancer_Homo sapiens_hsa052130.73603931
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.71456308
71HTLV-I infection_Homo sapiens_hsa051660.70817385
72Viral carcinogenesis_Homo sapiens_hsa052030.68179460
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65658155
74Amoebiasis_Homo sapiens_hsa051460.63832531
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.61319074
76Prostate cancer_Homo sapiens_hsa052150.60114320
77Bladder cancer_Homo sapiens_hsa052190.55799878
78Notch signaling pathway_Homo sapiens_hsa043300.55427333
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53868701
80Endocytosis_Homo sapiens_hsa041440.52974025
81ErbB signaling pathway_Homo sapiens_hsa040120.50302881
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.47020553
83Small cell lung cancer_Homo sapiens_hsa052220.46965578
84MAPK signaling pathway_Homo sapiens_hsa040100.45492900
85p53 signaling pathway_Homo sapiens_hsa041150.45133106
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43102180
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42561641
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41267703
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40932171
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40838425
91MicroRNAs in cancer_Homo sapiens_hsa052060.40050325
92Thyroid cancer_Homo sapiens_hsa052160.39628608
93Choline metabolism in cancer_Homo sapiens_hsa052310.39287059
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39121338
95Basal transcription factors_Homo sapiens_hsa030220.37559714
96Proteoglycans in cancer_Homo sapiens_hsa052050.36406074
97mTOR signaling pathway_Homo sapiens_hsa041500.34250935
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.33187743
99Type II diabetes mellitus_Homo sapiens_hsa049300.32410651
100Rap1 signaling pathway_Homo sapiens_hsa040150.31028155

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