PPP4R3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.24393894
2histone H3-K36 demethylation (GO:0070544)4.77782105
3mitotic sister chromatid cohesion (GO:0007064)4.65392763
4nuclear pore organization (GO:0006999)4.59755296
5regulation of RNA export from nucleus (GO:0046831)4.09745170
6regulation of histone H3-K27 methylation (GO:0061085)4.06611269
7positive regulation of gamma-delta T cell activation (GO:0046645)4.02661819
8pore complex assembly (GO:0046931)3.63098211
9regulation of nucleobase-containing compound transport (GO:0032239)3.50308339
10positive T cell selection (GO:0043368)3.40644293
11pre-miRNA processing (GO:0031054)3.39441190
12regulation of gamma-delta T cell differentiation (GO:0045586)3.35992792
13regulation of histone H3-K9 methylation (GO:0051570)3.29949619
14cytoplasmic mRNA processing body assembly (GO:0033962)3.27558706
15regulation of gamma-delta T cell activation (GO:0046643)3.26513948
16positive thymic T cell selection (GO:0045059)3.25656163
17embryonic process involved in female pregnancy (GO:0060136)3.24151104
18histone lysine demethylation (GO:0070076)3.23934637
19regulation of B cell receptor signaling pathway (GO:0050855)3.19248314
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.18836792
21histone H3-K4 trimethylation (GO:0080182)3.18585168
22monoubiquitinated protein deubiquitination (GO:0035520)3.18577184
23RNA stabilization (GO:0043489)3.17591309
24mRNA stabilization (GO:0048255)3.17591309
25negative thymic T cell selection (GO:0045060)3.16361757
26histone demethylation (GO:0016577)3.16129923
27negative T cell selection (GO:0043383)3.15448866
28negative regulation of histone methylation (GO:0031061)3.14337822
29B cell receptor signaling pathway (GO:0050853)3.02683488
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99253605
31negative regulation of cell killing (GO:0031342)2.99253605
32peptidyl-lysine trimethylation (GO:0018023)2.99043328
33T cell selection (GO:0045058)2.97755072
34histone H3-K9 demethylation (GO:0033169)2.94978544
35thymic T cell selection (GO:0045061)2.93547614
36mitotic chromosome condensation (GO:0007076)2.92338713
37dosage compensation (GO:0007549)2.85712408
38histone H3-K4 methylation (GO:0051568)2.83529432
39DNA unwinding involved in DNA replication (GO:0006268)2.83181023
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82145835
41negative regulation of DNA repair (GO:0045738)2.80005674
42negative regulation of erythrocyte differentiation (GO:0045647)2.76124460
43positive regulation of DNA-templated transcription, initiation (GO:2000144)2.75587427
44negative regulation of mRNA metabolic process (GO:1903312)2.75186603
45trophectodermal cell differentiation (GO:0001829)2.74140641
463-UTR-mediated mRNA stabilization (GO:0070935)2.73302499
47DNA topological change (GO:0006265)2.72995610
48antigen processing and presentation of endogenous antigen (GO:0019883)2.72848396
49protein demethylation (GO:0006482)2.71611397
50protein dealkylation (GO:0008214)2.71611397
51regulation of histone methylation (GO:0031060)2.69067398
52positive regulation of granulocyte differentiation (GO:0030854)2.68992965
53regulation of DNA damage checkpoint (GO:2000001)2.65811099
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65569217
55positive regulation by organism of defense response of other organism involved in symbiotic interact2.65569217
56modulation by symbiont of host immune response (GO:0052553)2.65569217
57positive regulation by symbiont of host defense response (GO:0052509)2.65569217
58modulation by symbiont of host defense response (GO:0052031)2.65569217
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65569217
60regulation of mRNA stability (GO:0043488)2.64920282
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64830478
62response to UV-C (GO:0010225)2.63570630
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62578016
64definitive hemopoiesis (GO:0060216)2.60540006
65hepatocyte apoptotic process (GO:0097284)2.59786174
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57808598
67histone H4-K16 acetylation (GO:0043984)2.55658202
68negative regulation of mRNA processing (GO:0050686)2.53903620
69alternative mRNA splicing, via spliceosome (GO:0000380)2.52608887
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52567605
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52118379
72DNA duplex unwinding (GO:0032508)2.51318657
73regulation of NFAT protein import into nucleus (GO:0051532)2.51287426
74regulation of fibroblast apoptotic process (GO:2000269)2.50340075
75B cell homeostasis (GO:0001782)2.48377555
76nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.48332662
77regulation of RNA stability (GO:0043487)2.47678131
78N-terminal protein amino acid acetylation (GO:0006474)2.44989074
79negative regulation of histone modification (GO:0031057)2.44879788
80B cell proliferation (GO:0042100)2.44017343
81V(D)J recombination (GO:0033151)2.43099101
82response to muramyl dipeptide (GO:0032495)2.42555998
83negative regulation of B cell proliferation (GO:0030889)2.41987293
84sister chromatid cohesion (GO:0007062)2.40272463
85negative regulation of T cell mediated immunity (GO:0002710)2.40230149
86regulation of chromatin silencing (GO:0031935)2.39734590
87positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.39634453
88spliceosomal tri-snRNP complex assembly (GO:0000244)2.39150352
89DNA geometric change (GO:0032392)2.38684740
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.38105370
91negative regulation of T-helper cell differentiation (GO:0045623)2.38105370
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.37967576
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.37967576
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37967576
95regulation of sister chromatid cohesion (GO:0007063)2.37639198
96DNA synthesis involved in DNA repair (GO:0000731)2.37616841
97regulation of interferon-beta biosynthetic process (GO:0045357)2.37135267
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37039445
99regulation of B cell differentiation (GO:0045577)2.33381452
100peptidyl-lysine methylation (GO:0018022)2.32932256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62144659
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.60203707
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.09595997
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.97157435
5MYC_22102868_ChIP-Seq_BL_Human3.43579670
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.37208710
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71623599
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67933757
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64534310
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42872791
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36520499
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.31349540
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29394844
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29281413
15GATA1_22025678_ChIP-Seq_K562_Human2.17007377
16MYB_26560356_Chip-Seq_TH2_Human2.14231120
17MYB_26560356_Chip-Seq_TH1_Human2.08435925
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05683864
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04633066
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03974740
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98244189
22TCF7_22412390_ChIP-Seq_EML_Mouse1.97818377
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.92163552
24RUNX_20019798_ChIP-Seq_JUKART_Human1.88596712
25SCL_19346495_ChIP-Seq_HPC-7_Human1.84499060
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82125259
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80840434
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.79428949
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77790244
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71460880
31MAF_26560356_Chip-Seq_TH1_Human1.68291306
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.67284422
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60502486
34CIITA_25753668_ChIP-Seq_RAJI_Human1.55534961
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55191423
36SPI1_23547873_ChIP-Seq_NB4_Human1.53230515
37VDR_21846776_ChIP-Seq_THP-1_Human1.51429196
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51335997
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48759104
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46396609
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44687188
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44687188
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44687188
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42632602
45CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42568874
46CHD1_26751641_Chip-Seq_LNCaP_Human1.40618813
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38904923
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37471648
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37302794
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.37243298
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36048248
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32495573
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31616545
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31366101
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.30969814
56VDR_24763502_ChIP-Seq_THP-1_Human1.30788006
57PU_27001747_Chip-Seq_BMDM_Mouse1.30664795
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30440221
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29966283
60UTX_26944678_Chip-Seq_JUKART_Human1.29929636
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.29694278
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28675029
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27573809
64TFEB_21752829_ChIP-Seq_HELA_Human1.27059133
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.25593063
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25208553
67AR_21909140_ChIP-Seq_LNCAP_Human1.24961216
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23858975
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23324043
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21677676
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.20143935
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.18087335
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17964044
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16526075
75GATA3_27048872_Chip-Seq_THYMUS_Human1.16123359
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13918057
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13489206
78KDM2B_26808549_Chip-Seq_DND41_Human1.12134462
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11204400
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08191437
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06888212
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.03371946
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03297610
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02028583
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.01486957
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01447567
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01447567
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00151024
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00120119
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00083171
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99975443
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99789561
93CLOCK_20551151_ChIP-Seq_293T_Human0.99303661
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99263156
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98789187
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97920886
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96296084
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.95829642
99MYC_18555785_ChIP-Seq_MESCs_Mouse0.93831468
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93352867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.06503980
2MP0002009_preneoplasia3.90194046
3MP0003763_abnormal_thymus_physiology3.03177107
4MP0010352_gastrointestinal_tract_polyps2.68552426
5MP0002396_abnormal_hematopoietic_system2.64155857
6MP0010234_abnormal_vibrissa_follicle2.56673345
7MP0002166_altered_tumor_susceptibility2.34659729
8MP0005076_abnormal_cell_differentiation2.22729464
9MP0004808_abnormal_hematopoietic_stem2.06850559
10MP0004957_abnormal_blastocyst_morpholog2.00770723
11MP0001835_abnormal_antigen_presentation1.98839126
12MP0003111_abnormal_nucleus_morphology1.95797644
13MP0003077_abnormal_cell_cycle1.92271455
14MP0010094_abnormal_chromosome_stability1.88384666
15MP0001800_abnormal_humoral_immune1.87424139
16MP0004264_abnormal_extraembryonic_tissu1.85665772
17MP0000703_abnormal_thymus_morphology1.84659794
18MP0003300_gastrointestinal_ulcer1.84550168
19MP0002877_abnormal_melanocyte_morpholog1.84194584
20MP0002796_impaired_skin_barrier1.81984494
21MP0004185_abnormal_adipocyte_glucose1.79768118
22MP0002398_abnormal_bone_marrow1.78541455
23MP0003693_abnormal_embryo_hatching1.76565580
24MP0002006_tumorigenesis1.72626794
25MP0003303_peritoneal_inflammation1.64567335
26MP0010307_abnormal_tumor_latency1.60668035
27MP0000350_abnormal_cell_proliferation1.60558251
28MP0001730_embryonic_growth_arrest1.58753843
29MP0003453_abnormal_keratinocyte_physiol1.48858654
30MP0002420_abnormal_adaptive_immunity1.46998423
31MP0002722_abnormal_immune_system1.45071689
32MP0000689_abnormal_spleen_morphology1.44928677
33MP0001819_abnormal_immune_cell1.44598601
34MP0002452_abnormal_antigen_presenting1.41291041
35MP0005000_abnormal_immune_tolerance1.40068137
36MP0000716_abnormal_immune_system1.37947943
37MP0003984_embryonic_growth_retardation1.37748172
38MP0010678_abnormal_skin_adnexa1.36134461
39MP0002088_abnormal_embryonic_growth/wei1.35462722
40MP0002723_abnormal_immune_serum1.34594736
41MP0005380_embryogenesis_phenotype1.34193295
42MP0001672_abnormal_embryogenesis/_devel1.34193295
43MP0001873_stomach_inflammation1.32867583
44MP0004947_skin_inflammation1.32824699
45MP0001853_heart_inflammation1.32630731
46MP0005310_abnormal_salivary_gland1.31797054
47MP0003890_abnormal_embryonic-extraembry1.31764032
48MP0003436_decreased_susceptibility_to1.30893214
49MP0000685_abnormal_immune_system1.30418473
50MP0005387_immune_system_phenotype1.30225183
51MP0001790_abnormal_immune_system1.30225183
52MP0002086_abnormal_extraembryonic_tissu1.28521433
53MP0004381_abnormal_hair_follicle1.27539392
54MP0003221_abnormal_cardiomyocyte_apopto1.24624764
55MP0002405_respiratory_system_inflammati1.24153076
56MP0005501_abnormal_skin_physiology1.23877725
57MP0009333_abnormal_splenocyte_physiolog1.22846861
58MP0001697_abnormal_embryo_size1.20888406
59MP0002429_abnormal_blood_cell1.19765328
60MP0010155_abnormal_intestine_physiology1.18604400
61MP0002138_abnormal_hepatobiliary_system1.18546468
62MP0003787_abnormal_imprinting1.18532670
63MP0000490_abnormal_crypts_of1.15467499
64MP0003828_pulmonary_edema1.14668897
65MP0005671_abnormal_response_to1.14529501
66MP0009672_abnormal_birth_weight1.12505753
67MP0004197_abnormal_fetal_growth/weight/1.12095256
68MP0005621_abnormal_cell_physiology1.08218911
69MP0003091_abnormal_cell_migration1.07663180
70MP0005451_abnormal_body_composition1.07329157
71MP0000313_abnormal_cell_death1.06601984
72MP0002019_abnormal_tumor_incidence1.04947881
73MP0001851_eye_inflammation1.03886430
74MP0008260_abnormal_autophagy1.02652347
75MP0002080_prenatal_lethality1.02443373
76MP0002254_reproductive_system_inflammat1.02147441
77MP0003656_abnormal_erythrocyte_physiolo1.01565802
78MP0001216_abnormal_epidermal_layer1.01198737
79MP0003705_abnormal_hypodermis_morpholog0.99562724
80MP0002419_abnormal_innate_immunity0.99316716
81MP0000383_abnormal_hair_follicle0.99004897
82MP0001915_intracranial_hemorrhage0.97662735
83MP0005025_abnormal_response_to0.97364799
84MP0002084_abnormal_developmental_patter0.96383245
85MP0009703_decreased_birth_body0.94481387
86MP0000465_gastrointestinal_hemorrhage0.92631685
87MP0008877_abnormal_DNA_methylation0.92239553
88MP0000858_altered_metastatic_potential0.91510427
89MP0003866_abnormal_defecation0.89846745
90MP0000377_abnormal_hair_follicle0.88701412
91MP0008007_abnormal_cellular_replicative0.86769757
92MP0000569_abnormal_digit_pigmentation0.85720138
93MP0001545_abnormal_hematopoietic_system0.85465893
94MP0005397_hematopoietic_system_phenotyp0.85465893
95MP0000537_abnormal_urethra_morphology0.85053793
96MP0002085_abnormal_embryonic_tissue0.84309558
97MP0003943_abnormal_hepatobiliary_system0.83893503
98MP0009278_abnormal_bone_marrow0.82817764
99MP0003566_abnormal_cell_adhesion0.82746294
100MP0005409_darkened_coat_color0.82002799

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)3.41194922
2Abnormality of the fingertips (HP:0001211)3.37653135
3Papillary thyroid carcinoma (HP:0002895)3.35199248
4Eczematoid dermatitis (HP:0000976)3.34447530
5Subacute progressive viral hepatitis (HP:0006572)2.95451971
6Abnormality of T cell number (HP:0011839)2.95208607
7Acute myeloid leukemia (HP:0004808)2.90795341
8Deep philtrum (HP:0002002)2.88173520
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82931920
10Curly hair (HP:0002212)2.78539011
11Recurrent viral infections (HP:0004429)2.72487954
12Transitional cell carcinoma of the bladder (HP:0006740)2.66565531
13Deep palmar crease (HP:0006191)2.57969181
14Neonatal hypoglycemia (HP:0001998)2.56866745
15Recurrent bacterial skin infections (HP:0005406)2.55398230
16Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.53766674
17Bladder carcinoma (HP:0002862)2.52467176
18Bladder neoplasm (HP:0009725)2.52467176
19Viral hepatitis (HP:0006562)2.51929148
20Progressive external ophthalmoplegia (HP:0000590)2.51409562
21Malignant gastrointestinal tract tumors (HP:0006749)2.49703559
22Gastrointestinal carcinoma (HP:0002672)2.49703559
23Heterotopia (HP:0002282)2.46396355
24Nephroblastoma (Wilms tumor) (HP:0002667)2.38708614
25IgM deficiency (HP:0002850)2.36257427
26Leiomyosarcoma (HP:0100243)2.34429963
27Uterine leiomyosarcoma (HP:0002891)2.34429963
28Recurrent bronchitis (HP:0002837)2.29991036
29Volvulus (HP:0002580)2.25835223
30Cellulitis (HP:0100658)2.25304425
31Colitis (HP:0002583)2.24299584
32Basal cell carcinoma (HP:0002671)2.23961746
33Syringomyelia (HP:0003396)2.21697393
34Spinal cord lesions (HP:0100561)2.21697393
35Recurrent abscess formation (HP:0002722)2.18980095
36Prominent nose (HP:0000448)2.18708832
37Embryonal renal neoplasm (HP:0011794)2.18429496
38IgA deficiency (HP:0002720)2.16553411
39Thyroid carcinoma (HP:0002890)2.16450788
40Germ cell neoplasia (HP:0100728)2.16206421
41Agammaglobulinemia (HP:0004432)2.15271876
42Vertebral arch anomaly (HP:0008438)2.15215120
43Osteomyelitis (HP:0002754)2.14880920
44Asymmetry of the thorax (HP:0001555)2.14155907
45Low anterior hairline (HP:0000294)2.14045852
46Autoimmune hemolytic anemia (HP:0001890)2.13729215
47Sandal gap (HP:0001852)2.07837744
48Selective tooth agenesis (HP:0001592)2.06049250
49Ankyloglossia (HP:0010296)2.05182060
50Lymphopenia (HP:0001888)2.02334351
51Meningitis (HP:0001287)2.00099744
52Abnormality of cells of the lymphoid lineage (HP:0012140)1.97493839
53Menstrual irregularities (HP:0000858)1.97139656
54Abnormal delayed hypersensitivity skin test (HP:0002963)1.96171464
55Short middle phalanx of the 5th finger (HP:0004220)1.93910311
56Abnormality of T cells (HP:0002843)1.92037400
57Cystic hygroma (HP:0000476)1.91773190
58Micronodular cirrhosis (HP:0001413)1.91334719
59Gastrointestinal inflammation (HP:0004386)1.90213347
60Chromsome breakage (HP:0040012)1.88931169
61Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88719616
62Verrucae (HP:0200043)1.87484412
63Papilloma (HP:0012740)1.87484412
64Overlapping toe (HP:0001845)1.87397327
65Neoplasm of the adrenal cortex (HP:0100641)1.87346649
66Abnormality of the distal phalanx of the thumb (HP:0009617)1.86971872
67Abnormality of chromosome segregation (HP:0002916)1.86941352
68Biliary tract neoplasm (HP:0100574)1.86234793
69Abnormality of chromosome stability (HP:0003220)1.85132320
70Inflammation of the large intestine (HP:0002037)1.85047967
71Spontaneous hematomas (HP:0007420)1.81845013
72Truncal obesity (HP:0001956)1.80695063
73Recurrent fungal infections (HP:0002841)1.80451489
74Abnormal foot bone ossification (HP:0010675)1.79422305
75Cafe-au-lait spot (HP:0000957)1.79339755
76Neoplasm of the tracheobronchial system (HP:0100552)1.77174491
77Lymphoma (HP:0002665)1.76948758
78Abnormality of oral frenula (HP:0000190)1.76905953
79Acute lymphatic leukemia (HP:0006721)1.76331872
80Panhypogammaglobulinemia (HP:0003139)1.75535572
81Narrow palate (HP:0000189)1.75420787
82Dislocated radial head (HP:0003083)1.74753223
83Cubitus valgus (HP:0002967)1.74698677
84Abnormality of the columella (HP:0009929)1.74162111
85Lip pit (HP:0100267)1.74157196
86Increased IgE level (HP:0003212)1.71375649
87Insidious onset (HP:0003587)1.71030618
88Termporal pattern (HP:0011008)1.71030618
89Myelodysplasia (HP:0002863)1.69859168
90Dysmetric saccades (HP:0000641)1.68570861
91Gastrointestinal stroma tumor (HP:0100723)1.66933094
92Coarse hair (HP:0002208)1.66787328
93Medulloblastoma (HP:0002885)1.66419080
94Deviation of the thumb (HP:0009603)1.66300729
95Macroorchidism (HP:0000053)1.66241298
96Flat acetabular roof (HP:0003180)1.66163764
97Broad palm (HP:0001169)1.65715754
98Chronic diarrhea (HP:0002028)1.65128461
99Amaurosis fugax (HP:0100576)1.64591035
100Slow saccadic eye movements (HP:0000514)1.64238129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.68362050
2MAP3K103.58039120
3BRD43.05926903
4PRPF4B2.80367738
5MAP3K142.06976040
6MAP4K12.06849312
7SMG12.02703541
8EEF2K1.83818324
9STK241.81030498
10TAF11.78929587
11CDK61.78797454
12MKNK21.77433245
13MAP3K131.73336334
14FGFR31.68055777
15PASK1.63200018
16TRIB31.58633118
17RPS6KB21.51058481
18SIK31.48416904
19MKNK11.48361570
20YES11.47355645
21CDC71.46897872
22SCYL21.45631354
23FGFR41.44644728
24SRPK11.37231970
25IRAK41.28444871
26IRAK21.26548190
27NLK1.25220288
28MST41.23647255
29CDK41.23187743
30IKBKE1.20659160
31CSK1.15807039
32RIPK41.15624973
33MELK1.11518416
34LATS11.09361292
35TYK21.08138007
36JAK11.07540815
37BTK1.06156508
38EIF2AK31.04254978
39STK100.99851256
40STK30.98526746
41RPS6KA40.95215613
42MAP3K20.92863915
43TEC0.87814594
44FGFR20.87004490
45JAK30.86562601
46PIM10.86192635
47MAP3K90.85968846
48KSR10.84656140
49SGK30.84651797
50FGR0.83994862
51CAMK1G0.82840993
52NEK90.81786506
53CHEK10.81329741
54ALK0.80836288
55TTK0.80770576
56MARK30.80065751
57IRAK10.79930516
58SGK20.79872889
59BRSK20.79339129
60AKT30.79105546
61STK40.76819667
62MTOR0.76067770
63PKN20.75323172
64ITK0.75085027
65KSR20.74886160
66BLK0.73424481
67TXK0.72581734
68CHUK0.69505322
69CDK90.69358966
70CSF1R0.67035114
71MAP3K10.67015664
72SIK10.66871801
73PDGFRB0.65265690
74RPS6KB10.64281191
75CDK70.63647397
76ICK0.63597587
77TRPM70.62759946
78JAK20.62083960
79GRK60.59555942
80MAP2K30.58625015
81RIPK10.58356112
82CAMK1D0.57923380
83HCK0.56143998
84FES0.54182628
85ZAP700.53339261
86HIPK20.53286932
87PDGFRA0.51975734
88LCK0.51781682
89TSSK60.51616237
90NEK60.51295589
91BMPR20.50725185
92ATM0.49449920
93TYRO30.49291886
94DYRK30.47841630
95SYK0.47802446
96ATR0.47628233
97FGFR10.47570838
98PTK60.47553946
99RET0.47040106
100RAF10.46919161

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.41286498
2Chronic myeloid leukemia_Homo sapiens_hsa052202.07694756
3Non-small cell lung cancer_Homo sapiens_hsa052231.97908254
4T cell receptor signaling pathway_Homo sapiens_hsa046601.97692273
5Acute myeloid leukemia_Homo sapiens_hsa052211.91837064
6Pancreatic cancer_Homo sapiens_hsa052121.77082917
7Thyroid cancer_Homo sapiens_hsa052161.75117908
8Endometrial cancer_Homo sapiens_hsa052131.72142600
9Measles_Homo sapiens_hsa051621.67664475
10Renal cell carcinoma_Homo sapiens_hsa052111.67548718
11mRNA surveillance pathway_Homo sapiens_hsa030151.64419177
12Herpes simplex infection_Homo sapiens_hsa051681.62968158
13Colorectal cancer_Homo sapiens_hsa052101.61342106
14Prostate cancer_Homo sapiens_hsa052151.61150960
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.54717295
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54184622
17Hepatitis B_Homo sapiens_hsa051611.53642319
18Primary immunodeficiency_Homo sapiens_hsa053401.52805667
19Spliceosome_Homo sapiens_hsa030401.46655689
20Osteoclast differentiation_Homo sapiens_hsa043801.44900460
21Viral carcinogenesis_Homo sapiens_hsa052031.41709764
22Leishmaniasis_Homo sapiens_hsa051401.41287294
23MicroRNAs in cancer_Homo sapiens_hsa052061.41092550
24Cell cycle_Homo sapiens_hsa041101.36172687
25Influenza A_Homo sapiens_hsa051641.33561214
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32065658
27Prolactin signaling pathway_Homo sapiens_hsa049171.31013432
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27444198
29Non-homologous end-joining_Homo sapiens_hsa034501.25079248
30FoxO signaling pathway_Homo sapiens_hsa040681.24074920
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21264765
32Inositol phosphate metabolism_Homo sapiens_hsa005621.19970238
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19290158
34Dorso-ventral axis formation_Homo sapiens_hsa043201.16841297
35Hepatitis C_Homo sapiens_hsa051601.16172224
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.15565424
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15408876
38RNA transport_Homo sapiens_hsa030131.15364679
39mTOR signaling pathway_Homo sapiens_hsa041501.15259972
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14768681
41ErbB signaling pathway_Homo sapiens_hsa040121.13286434
42HTLV-I infection_Homo sapiens_hsa051661.12431888
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.10764795
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09834956
45Adherens junction_Homo sapiens_hsa045201.08475268
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07796808
47Apoptosis_Homo sapiens_hsa042101.07387834
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07008792
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05240646
50Small cell lung cancer_Homo sapiens_hsa052221.05154562
51Epstein-Barr virus infection_Homo sapiens_hsa051691.05005888
52Toxoplasmosis_Homo sapiens_hsa051451.04411916
53TNF signaling pathway_Homo sapiens_hsa046681.04004987
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.03767702
55Choline metabolism in cancer_Homo sapiens_hsa052311.01279770
56Antigen processing and presentation_Homo sapiens_hsa046121.00647129
57Autoimmune thyroid disease_Homo sapiens_hsa053201.00023714
58VEGF signaling pathway_Homo sapiens_hsa043701.00023344
59Allograft rejection_Homo sapiens_hsa053300.99438496
60p53 signaling pathway_Homo sapiens_hsa041150.99168078
61Chemokine signaling pathway_Homo sapiens_hsa040620.95877454
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95532848
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95363646
64Glioma_Homo sapiens_hsa052140.95198844
65Graft-versus-host disease_Homo sapiens_hsa053320.94690859
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92025087
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90670923
68Notch signaling pathway_Homo sapiens_hsa043300.90360320
69Bladder cancer_Homo sapiens_hsa052190.89415049
70Tuberculosis_Homo sapiens_hsa051520.88432248
71Viral myocarditis_Homo sapiens_hsa054160.88151231
72Hematopoietic cell lineage_Homo sapiens_hsa046400.85383241
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84682420
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.83622783
75Proteoglycans in cancer_Homo sapiens_hsa052050.82115224
76Lysine degradation_Homo sapiens_hsa003100.81324464
77Platelet activation_Homo sapiens_hsa046110.81046600
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.79418195
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.79193647
80Legionellosis_Homo sapiens_hsa051340.77015547
81Insulin resistance_Homo sapiens_hsa049310.73969375
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72692827
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72618096
84Insulin signaling pathway_Homo sapiens_hsa049100.71975612
85Type I diabetes mellitus_Homo sapiens_hsa049400.71582833
86DNA replication_Homo sapiens_hsa030300.69798345
87RNA degradation_Homo sapiens_hsa030180.66982324
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66095210
89Systemic lupus erythematosus_Homo sapiens_hsa053220.63916352
90Shigellosis_Homo sapiens_hsa051310.63437151
91HIF-1 signaling pathway_Homo sapiens_hsa040660.62758497
92Staphylococcus aureus infection_Homo sapiens_hsa051500.59292658
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.57578902
94Estrogen signaling pathway_Homo sapiens_hsa049150.57433311
95Pathways in cancer_Homo sapiens_hsa052000.57350773
96Basal transcription factors_Homo sapiens_hsa030220.55519103
97Type II diabetes mellitus_Homo sapiens_hsa049300.54924924
98Long-term potentiation_Homo sapiens_hsa047200.54645214
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52973019
100MAPK signaling pathway_Homo sapiens_hsa040100.52111103

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