PPP4R3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.89013544
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.29889724
3positive regulation of gamma-delta T cell activation (GO:0046645)4.17486599
4nuclear pore organization (GO:0006999)3.91233079
5embryonic process involved in female pregnancy (GO:0060136)3.77204522
6cilium or flagellum-dependent cell motility (GO:0001539)3.76356568
7positive regulation of granulocyte differentiation (GO:0030854)3.67346800
8negative regulation of immunoglobulin mediated immune response (GO:0002890)3.65980167
9negative regulation of B cell mediated immunity (GO:0002713)3.65980167
10cellular response to ethanol (GO:0071361)3.62223910
11negative regulation of cell killing (GO:0031342)3.54242740
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54242740
13regulation of RNA export from nucleus (GO:0046831)3.54229629
14pore complex assembly (GO:0046931)3.47209677
15regulation of B cell receptor signaling pathway (GO:0050855)3.40957791
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39988366
17definitive hemopoiesis (GO:0060216)3.36710383
18histone H3-K36 demethylation (GO:0070544)3.34958625
19negative T cell selection (GO:0043383)3.34296100
20negative thymic T cell selection (GO:0045060)3.31498369
21regulation of gamma-delta T cell differentiation (GO:0045586)3.26353202
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24305557
23regulation of nucleobase-containing compound transport (GO:0032239)3.22191545
24hepatocyte apoptotic process (GO:0097284)3.17112613
25dosage compensation (GO:0007549)3.16710164
26germinal center formation (GO:0002467)3.15673043
27regulation of histone H3-K27 methylation (GO:0061085)3.13871411
28B cell receptor signaling pathway (GO:0050853)3.09115935
29antigen processing and presentation of endogenous antigen (GO:0019883)3.05836951
30histone lysine demethylation (GO:0070076)3.05783349
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04398399
32regulation of gamma-delta T cell activation (GO:0046643)3.03230692
33negative regulation of lymphocyte mediated immunity (GO:0002707)2.97368342
34COPI coating of Golgi vesicle (GO:0048205)2.96738037
35Golgi transport vesicle coating (GO:0048200)2.96738037
36negative regulation of humoral immune response (GO:0002921)2.94010386
37monoubiquitinated protein deubiquitination (GO:0035520)2.92708742
38hypotonic response (GO:0006971)2.91236032
39cytoplasmic mRNA processing body assembly (GO:0033962)2.88491532
40histone H3-K9 demethylation (GO:0033169)2.86882383
41histone demethylation (GO:0016577)2.84970678
42positive regulation of B cell differentiation (GO:0045579)2.79820152
43regulation of necroptotic process (GO:0060544)2.78393879
44positive T cell selection (GO:0043368)2.77708811
45negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76592363
46protein localization to endosome (GO:0036010)2.75776110
47T cell selection (GO:0045058)2.71698548
48tachykinin receptor signaling pathway (GO:0007217)2.68491170
49negative regulation of adaptive immune response (GO:0002820)2.68413711
50iron ion import (GO:0097286)2.66085636
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63506095
52response to interleukin-15 (GO:0070672)2.63421567
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63272361
54negative regulation of T-helper cell differentiation (GO:0045623)2.63272361
55COPII vesicle coating (GO:0048208)2.59475731
56retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56745506
57protein demethylation (GO:0006482)2.54614272
58protein dealkylation (GO:0008214)2.54614272
59mitotic sister chromatid cohesion (GO:0007064)2.53772646
60protein targeting to Golgi (GO:0000042)2.53640723
61negative regulation of complement activation (GO:0045916)2.53563578
62negative regulation of type 2 immune response (GO:0002829)2.53333465
63establishment of protein localization to Golgi (GO:0072600)2.52579313
64positive regulation of tolerance induction (GO:0002645)2.51391564
65nerve growth factor signaling pathway (GO:0038180)2.48547177
66Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48188485
67poly(A)+ mRNA export from nucleus (GO:0016973)2.46834563
68negative regulation of protein activation cascade (GO:2000258)2.46172099
69response to nerve growth factor (GO:1990089)2.45347386
70cellular response to nerve growth factor stimulus (GO:1990090)2.45347386
71tolerance induction (GO:0002507)2.44906785
72peptidyl-threonine modification (GO:0018210)2.41149291
73activated T cell proliferation (GO:0050798)2.39444578
74regulation of granulocyte differentiation (GO:0030852)2.37379790
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37104296
76phospholipid translocation (GO:0045332)2.36928462
77lipid translocation (GO:0034204)2.36928462
78axonemal dynein complex assembly (GO:0070286)2.35255693
79negative regulation of erythrocyte differentiation (GO:0045647)2.35196685
80peptidyl-threonine phosphorylation (GO:0018107)2.32575672
81regulation of establishment of cell polarity (GO:2000114)2.32384600
82Golgi to endosome transport (GO:0006895)2.32382349
83establishment of protein localization to vacuole (GO:0072666)2.31222322
84protein targeting to vacuole (GO:0006623)2.31222322
85protein targeting to lysosome (GO:0006622)2.31222322
86regulation of regulatory T cell differentiation (GO:0045589)2.30204936
87necrotic cell death (GO:0070265)2.28740215
88thymic T cell selection (GO:0045061)2.26440731
89negative regulation of leukocyte mediated immunity (GO:0002704)2.26179374
90negative regulation of T cell mediated immunity (GO:0002710)2.25807294
91nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.25606923
92T cell mediated immunity (GO:0002456)2.25233771
93detection of other organism (GO:0098543)2.25187735
94regulation of ARF protein signal transduction (GO:0032012)2.24667712
95early endosome to late endosome transport (GO:0045022)2.24516534
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23669887
97interleukin-6-mediated signaling pathway (GO:0070102)2.23514954
98regulation of NFAT protein import into nucleus (GO:0051532)2.23442240
99neutrophil mediated immunity (GO:0002446)2.23251420
100regulation of tolerance induction (GO:0002643)2.22389974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87917050
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23924172
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.02242094
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92795046
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77263820
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.75227823
7GATA1_22025678_ChIP-Seq_K562_Human2.48657599
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.47165626
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46336465
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.42695397
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26928617
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25223972
13RUNX_20019798_ChIP-Seq_JUKART_Human2.19125559
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17833656
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14765680
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12098201
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10936679
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09224617
19MYB_26560356_Chip-Seq_TH2_Human1.97638174
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83699444
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77992266
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.75256759
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70494573
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69874639
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69134765
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.68819611
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.68708264
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67556508
29SCL_19346495_ChIP-Seq_HPC-7_Human1.66916366
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66090121
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63487501
32MYB_26560356_Chip-Seq_TH1_Human1.62001405
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58177896
34AHR_22903824_ChIP-Seq_MCF-7_Human1.51261722
35FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51060230
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.51034262
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.49884273
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.48641562
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47112484
40GATA3_27048872_Chip-Seq_THYMUS_Human1.46164141
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44699380
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44022703
43IGF1R_20145208_ChIP-Seq_DFB_Human1.43175127
44CLOCK_20551151_ChIP-Seq_293T_Human1.39613280
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36040930
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34600359
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30956836
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28925259
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28625508
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26035951
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25508672
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24049713
53PU_27001747_Chip-Seq_BMDM_Mouse1.23870587
54VDR_24787735_ChIP-Seq_THP-1_Human1.23490277
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.21578437
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.21123283
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19665807
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18679726
59GATA2_19941826_ChIP-Seq_K562_Human1.18373239
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18305497
61SPI1_23127762_ChIP-Seq_K562_Human1.18232779
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.17627945
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15715538
64TAF15_26573619_Chip-Seq_HEK293_Human1.14787947
65SPI1_23547873_ChIP-Seq_NB4_Human1.14335903
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12092971
67TCF7_22412390_ChIP-Seq_EML_Mouse1.11696539
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11377336
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11005686
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11005686
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10358743
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.09210584
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08662176
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08471740
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07663921
76FUS_26573619_Chip-Seq_HEK293_Human1.07061383
77ER_23166858_ChIP-Seq_MCF-7_Human1.07042321
78MYC_22102868_ChIP-Seq_BL_Human1.05845868
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05184954
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05184954
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.05147839
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03823261
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.02896613
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.02450229
85TP53_16413492_ChIP-PET_HCT116_Human1.02169276
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.01866430
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01518129
88GATA1_19941826_ChIP-Seq_K562_Human1.01330329
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.00518241
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00418664
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.00351552
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99564140
93STAT3_23295773_ChIP-Seq_U87_Human0.99091246
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98050181
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97918716
96MAF_26560356_Chip-Seq_TH1_Human0.97826945
97AR_21572438_ChIP-Seq_LNCaP_Human0.97796094
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97286237
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97201690
100CIITA_25753668_ChIP-Seq_RAJI_Human0.96292018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.51654873
2MP0002166_altered_tumor_susceptibility2.98089587
3MP0003300_gastrointestinal_ulcer2.90616918
4MP0003763_abnormal_thymus_physiology2.83442286
5MP0008057_abnormal_DNA_replication2.82127616
6MP0010352_gastrointestinal_tract_polyps2.74732381
7MP0003656_abnormal_erythrocyte_physiolo2.46802005
8MP0000465_gastrointestinal_hemorrhage2.45233869
9MP0002396_abnormal_hematopoietic_system2.34927289
10MP0001835_abnormal_antigen_presentation2.34246349
11MP0010234_abnormal_vibrissa_follicle2.26535547
12MP0003303_peritoneal_inflammation2.07882978
13MP0003183_abnormal_peptide_metabolism2.06863809
14MP0000569_abnormal_digit_pigmentation2.06291141
15MP0002877_abnormal_melanocyte_morpholog1.96213169
16MP0003724_increased_susceptibility_to1.94561522
17MP0004264_abnormal_extraembryonic_tissu1.93903833
18MP0003191_abnormal_cellular_cholesterol1.90178718
19MP0002006_tumorigenesis1.82499776
20MP0003221_abnormal_cardiomyocyte_apopto1.81129788
21MP0005451_abnormal_body_composition1.80866749
22MP0004381_abnormal_hair_follicle1.80108645
23MP0010678_abnormal_skin_adnexa1.78750706
24MP0005076_abnormal_cell_differentiation1.78361325
25MP0001800_abnormal_humoral_immune1.75318178
26MP0003868_abnormal_feces_composition1.70206918
27MP0008260_abnormal_autophagy1.69350712
28MP0000383_abnormal_hair_follicle1.66760524
29MP0010155_abnormal_intestine_physiology1.66321381
30MP0003866_abnormal_defecation1.62638616
31MP0004947_skin_inflammation1.57708257
32MP0002398_abnormal_bone_marrow1.46793333
33MP0005464_abnormal_platelet_physiology1.44161414
34MP0003890_abnormal_embryonic-extraembry1.43426612
35MP0000685_abnormal_immune_system1.41894042
36MP0003091_abnormal_cell_migration1.40627214
37MP0000703_abnormal_thymus_morphology1.39074000
38MP0004185_abnormal_adipocyte_glucose1.32699721
39MP0002420_abnormal_adaptive_immunity1.31008445
40MP0005000_abnormal_immune_tolerance1.30636328
41MP0004043_abnormal_pH_regulation1.29753334
42MP0000689_abnormal_spleen_morphology1.29751341
43MP0002722_abnormal_immune_system1.29447585
44MP0001851_eye_inflammation1.29257609
45MP0004808_abnormal_hematopoietic_stem1.29232402
46MP0001819_abnormal_immune_cell1.28887612
47MP0005409_darkened_coat_color1.28805095
48MP0002452_abnormal_antigen_presenting1.28678393
49MP0002723_abnormal_immune_serum1.28133200
50MP0001666_abnormal_nutrient_absorption1.27830859
51MP0002405_respiratory_system_inflammati1.25383350
52MP0005671_abnormal_response_to1.23800882
53MP0001790_abnormal_immune_system1.18343466
54MP0005387_immune_system_phenotype1.18343466
55MP0003436_decreased_susceptibility_to1.17621742
56MP0005025_abnormal_response_to1.16912000
57MP0000716_abnormal_immune_system1.16645035
58MP0005310_abnormal_salivary_gland1.16441664
59MP0002419_abnormal_innate_immunity1.14922659
60MP0001915_intracranial_hemorrhage1.10386995
61MP0003252_abnormal_bile_duct1.09763090
62MP0003690_abnormal_glial_cell1.07583409
63MP0005408_hypopigmentation1.07370934
64MP0010307_abnormal_tumor_latency1.07216411
65MP0000377_abnormal_hair_follicle1.06173438
66MP0003453_abnormal_keratinocyte_physiol1.06056934
67MP0004782_abnormal_surfactant_physiolog1.05675459
68MP0005365_abnormal_bile_salt1.00832757
69MP0003787_abnormal_imprinting0.99532051
70MP0005621_abnormal_cell_physiology0.98543198
71MP0000609_abnormal_liver_physiology0.96655780
72MP0005666_abnormal_adipose_tissue0.95433746
73MP0002971_abnormal_brown_adipose0.95281694
74MP0005075_abnormal_melanosome_morpholog0.94906189
75MP0002429_abnormal_blood_cell0.93836234
76MP0009115_abnormal_fat_cell0.93719808
77MP0002086_abnormal_extraembryonic_tissu0.92547991
78MP0000858_altered_metastatic_potential0.92522108
79MP0010386_abnormal_urinary_bladder0.91899266
80MP0004883_abnormal_blood_vessel0.91370278
81MP0001845_abnormal_inflammatory_respons0.91043624
82MP0005085_abnormal_gallbladder_physiolo0.90133749
83MP0001216_abnormal_epidermal_layer0.88050789
84MP0005248_abnormal_Harderian_gland0.84836831
85MP0002132_abnormal_respiratory_system0.84798639
86MP0003172_abnormal_lysosome_physiology0.83938446
87MP0002796_impaired_skin_barrier0.83576154
88MP0002139_abnormal_hepatobiliary_system0.83295016
89MP0003828_pulmonary_edema0.79667872
90MP0000427_abnormal_hair_cycle0.74666701
91MP0002098_abnormal_vibrissa_morphology0.74515305
92MP0009785_altered_susceptibility_to0.73279417
93MP0009763_increased_sensitivity_to0.72977928
94MP0003943_abnormal_hepatobiliary_system0.72971163
95MP0005384_cellular_phenotype0.70645317
96MP0000371_diluted_coat_color0.70432373
97MP0001873_stomach_inflammation0.69642215
98MP0004197_abnormal_fetal_growth/weight/0.66410269
99MP0010329_abnormal_lipoprotein_level0.66240811
100MP0002019_abnormal_tumor_incidence0.66045636

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.71288059
2Thyroid carcinoma (HP:0002890)3.13313214
3T lymphocytopenia (HP:0005403)3.12284619
4Eczematoid dermatitis (HP:0000976)2.89812995
5Subacute progressive viral hepatitis (HP:0006572)2.86037909
6Abnormality of T cell number (HP:0011839)2.84693691
7Recurrent bronchitis (HP:0002837)2.82109166
8Insidious onset (HP:0003587)2.73610310
9Termporal pattern (HP:0011008)2.73610310
10Curly hair (HP:0002212)2.73254815
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72688083
12Rhinitis (HP:0012384)2.55895088
13Heterotopia (HP:0002282)2.55349352
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.48481180
15Absent/shortened dynein arms (HP:0200106)2.48481180
16Bronchiectasis (HP:0002110)2.46431869
17Absent frontal sinuses (HP:0002688)2.43671981
18Flat acetabular roof (HP:0003180)2.38673271
19Coarse hair (HP:0002208)2.38507952
20Abnormal respiratory epithelium morphology (HP:0012253)2.37482901
21Abnormal respiratory motile cilium morphology (HP:0005938)2.37482901
22Recurrent sinusitis (HP:0011108)2.37119439
23Bronchitis (HP:0012387)2.31463619
24Viral hepatitis (HP:0006562)2.30433732
25Abnormality of the fingertips (HP:0001211)2.30069038
26Abnormal ciliary motility (HP:0012262)2.26817946
27Recurrent bacterial skin infections (HP:0005406)2.26521203
28Abnormal respiratory motile cilium physiology (HP:0012261)2.26364623
29Recurrent viral infections (HP:0004429)2.24823108
30Hypoplasia of the thymus (HP:0000778)2.23448941
31Chronic diarrhea (HP:0002028)2.21632494
32Colitis (HP:0002583)2.19843602
33Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17425534
34Deep philtrum (HP:0002002)2.15484453
35Autoimmune hemolytic anemia (HP:0001890)2.13461230
36Gingival bleeding (HP:0000225)2.10824753
37Spontaneous hematomas (HP:0007420)2.10239925
38Asymmetry of the thorax (HP:0001555)2.09555385
39Chronic otitis media (HP:0000389)2.04979165
40Syringomyelia (HP:0003396)2.04909452
41Spinal cord lesions (HP:0100561)2.04909452
42Menstrual irregularities (HP:0000858)2.03060869
43Macroorchidism (HP:0000053)2.01590595
44Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.99952404
45Recurrent abscess formation (HP:0002722)1.99748945
46Vertebral arch anomaly (HP:0008438)1.98056516
47Periodontitis (HP:0000704)1.97986136
48Nasal polyposis (HP:0100582)1.96915771
49Recurrent otitis media (HP:0000403)1.96255992
50Thickened calvaria (HP:0002684)1.95938393
51Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92926330
52Overlapping toe (HP:0001845)1.92777349
53Abnormality of the common coagulation pathway (HP:0010990)1.92748189
54Gastrointestinal infarctions (HP:0005244)1.92454684
55Transitional cell carcinoma of the bladder (HP:0006740)1.91546305
56Acute myeloid leukemia (HP:0004808)1.89341785
57Acanthocytosis (HP:0001927)1.89157547
58Prolonged bleeding time (HP:0003010)1.88527117
59Malignant gastrointestinal tract tumors (HP:0006749)1.87163577
60Gastrointestinal carcinoma (HP:0002672)1.87163577
61Ankyloglossia (HP:0010296)1.87141998
62Gingivitis (HP:0000230)1.86523918
63Inflammation of the large intestine (HP:0002037)1.86323363
64Osteomyelitis (HP:0002754)1.84821927
65Truncal obesity (HP:0001956)1.84136756
66Hip dysplasia (HP:0001385)1.83972424
67Gastrointestinal inflammation (HP:0004386)1.83713804
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83401441
69Bladder carcinoma (HP:0002862)1.83353551
70Bladder neoplasm (HP:0009725)1.83353551
71Biliary tract neoplasm (HP:0100574)1.82300221
72Medulloblastoma (HP:0002885)1.81600757
73Scanning speech (HP:0002168)1.81410747
74Neoplasm of the tracheobronchial system (HP:0100552)1.80820831
75Recurrent gram-negative bacterial infections (HP:0005420)1.80604183
76Cystic hygroma (HP:0000476)1.80121081
77Granulocytopenia (HP:0001913)1.79841660
78Eosinophilia (HP:0001880)1.75698414
79Amyotrophic lateral sclerosis (HP:0007354)1.74382031
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74257927
81Cellulitis (HP:0100658)1.73613656
82Prominent nose (HP:0000448)1.73508701
83Broad palm (HP:0001169)1.71627020
84Blue irides (HP:0000635)1.70033922
85Chronic sinusitis (HP:0011109)1.69392083
86Micronodular cirrhosis (HP:0001413)1.69329905
87Interstitial pulmonary disease (HP:0006530)1.68136082
88Meningitis (HP:0001287)1.67411953
89Mediastinal lymphadenopathy (HP:0100721)1.65450145
90Tubulointerstitial nephritis (HP:0001970)1.64631153
91Abnormal platelet volume (HP:0011876)1.64610074
92Severe combined immunodeficiency (HP:0004430)1.64472907
93Abnormal foot bone ossification (HP:0010675)1.63572851
94Recurrent fungal infections (HP:0002841)1.63330551
95Fair hair (HP:0002286)1.62336361
96Germ cell neoplasia (HP:0100728)1.62212735
97Leiomyosarcoma (HP:0100243)1.61283821
98Uterine leiomyosarcoma (HP:0002891)1.61283821
99Tapered finger (HP:0001182)1.61280696
100Panhypogammaglobulinemia (HP:0003139)1.60391505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.09405792
2BCR2.67361348
3BRD42.41454028
4FGFR32.40810228
5SCYL22.33590849
6MAP3K142.31287203
7EPHA32.01823582
8FGFR41.96675231
9EEF2K1.96311963
10SIK31.92663697
11MAP3K101.88579002
12ERBB31.87745519
13PRPF4B1.86085248
14BMPR21.81311159
15RIPK41.80448263
16PKN21.76662435
17MAP3K21.71613692
18CDK61.65599502
19MAP3K41.59073099
20LATS11.58424652
21JAK11.47593317
22AKT31.47580855
23NEK61.46647761
24YES11.45735925
25SIK21.36725732
26EIF2AK31.29425695
27BTK1.28401331
28CSK1.23060000
29SGK21.21719043
30TAOK31.20734241
31MAP4K11.19679963
32RIPK11.18705766
33RET1.18333035
34ACVR1B1.17130111
35TYK21.14339869
36SGK31.13965407
37MARK21.13943039
38CAMKK21.12760104
39RPS6KA41.12616133
40KSR11.10393985
41NEK91.08154673
42TRPM71.04425034
43TRIB31.02215299
44JAK21.01381480
45MAP3K61.00847819
46EIF2AK11.00216512
47NLK0.99808715
48WNK10.99486302
49FES0.94258583
50ICK0.93966727
51DYRK1B0.93786057
52PDGFRA0.93342212
53SRPK10.90440225
54HCK0.89345574
55KSR20.86028959
56STK240.85658725
57TEC0.84758687
58BLK0.84066913
59JAK30.83269523
60IKBKE0.83197931
61MAPK110.82874587
62GRK60.78964336
63EPHB10.78869858
64TXK0.78385125
65LCK0.77152987
66ITK0.76499313
67MAP2K40.72414494
68SYK0.71603954
69PDGFRB0.71558748
70RPS6KB10.71248500
71SGK4940.70127129
72SGK2230.70127129
73IRAK40.69705799
74MAP3K130.68082428
75MST1R0.67341292
76IRAK10.66545278
77CSF1R0.65827536
78MAP3K10.64518890
79DYRK30.63973314
80STK30.60920685
81MAP3K70.60800177
82RPS6KB20.60671285
83LYN0.60463866
84FGR0.60456177
85ERBB20.59415504
86CLK10.57439375
87PDK10.57339574
88ZAP700.57069172
89FER0.55595237
90MELK0.54959203
91CDK40.54649825
92MAP2K70.54355185
93BRSK20.50964142
94SGK10.49052222
95RAF10.47655427
96MAPK100.45164957
97MAPK70.44433534
98CHUK0.42833808
99TAOK10.42204761
100TGFBR20.40181084

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.06187566
2Pancreatic cancer_Homo sapiens_hsa052121.88712649
3Non-small cell lung cancer_Homo sapiens_hsa052231.86280113
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71246627
5Chronic myeloid leukemia_Homo sapiens_hsa052201.62850587
6Acute myeloid leukemia_Homo sapiens_hsa052211.61246544
7T cell receptor signaling pathway_Homo sapiens_hsa046601.52977001
8Prolactin signaling pathway_Homo sapiens_hsa049171.51550503
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50349624
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50059129
11Endometrial cancer_Homo sapiens_hsa052131.44079064
12mTOR signaling pathway_Homo sapiens_hsa041501.42097353
13Thyroid cancer_Homo sapiens_hsa052161.36567277
14Renal cell carcinoma_Homo sapiens_hsa052111.35579062
15Colorectal cancer_Homo sapiens_hsa052101.35261463
16Measles_Homo sapiens_hsa051621.32719994
17Osteoclast differentiation_Homo sapiens_hsa043801.30127260
18Inositol phosphate metabolism_Homo sapiens_hsa005621.29278353
19Choline metabolism in cancer_Homo sapiens_hsa052311.25938187
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24596572
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.22754103
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.21948514
23Hepatitis B_Homo sapiens_hsa051611.21863374
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21111980
25Hepatitis C_Homo sapiens_hsa051601.19835287
26Leishmaniasis_Homo sapiens_hsa051401.17552798
27Dorso-ventral axis formation_Homo sapiens_hsa043201.15840873
28ErbB signaling pathway_Homo sapiens_hsa040121.12120029
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.10055673
30FoxO signaling pathway_Homo sapiens_hsa040681.10046385
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09347781
32Influenza A_Homo sapiens_hsa051641.06719944
33Herpes simplex infection_Homo sapiens_hsa051681.06676127
34Adherens junction_Homo sapiens_hsa045201.06344121
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05118161
36Viral carcinogenesis_Homo sapiens_hsa052031.04595029
37Platelet activation_Homo sapiens_hsa046111.03457388
38Toxoplasmosis_Homo sapiens_hsa051451.00376594
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00261609
40Chemokine signaling pathway_Homo sapiens_hsa040620.99653195
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99079915
42Staphylococcus aureus infection_Homo sapiens_hsa051500.98989240
43Prostate cancer_Homo sapiens_hsa052150.98751451
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98370107
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97792093
46Sphingolipid signaling pathway_Homo sapiens_hsa040710.94613226
47Insulin resistance_Homo sapiens_hsa049310.92390793
48ABC transporters_Homo sapiens_hsa020100.92371922
49Circadian rhythm_Homo sapiens_hsa047100.91977951
50Tuberculosis_Homo sapiens_hsa051520.90521069
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90417725
52TNF signaling pathway_Homo sapiens_hsa046680.88767081
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.88752469
54Glioma_Homo sapiens_hsa052140.87988478
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.86665277
56Small cell lung cancer_Homo sapiens_hsa052220.84198989
57AMPK signaling pathway_Homo sapiens_hsa041520.81187473
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80486613
59Renin-angiotensin system_Homo sapiens_hsa046140.80443894
60Primary immunodeficiency_Homo sapiens_hsa053400.80211532
61VEGF signaling pathway_Homo sapiens_hsa043700.79101343
62Fatty acid biosynthesis_Homo sapiens_hsa000610.78603097
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77418157
64Insulin signaling pathway_Homo sapiens_hsa049100.76363377
65Hematopoietic cell lineage_Homo sapiens_hsa046400.75426719
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74149232
67Type II diabetes mellitus_Homo sapiens_hsa049300.72885098
68mRNA surveillance pathway_Homo sapiens_hsa030150.72383271
69Graft-versus-host disease_Homo sapiens_hsa053320.72113437
70Apoptosis_Homo sapiens_hsa042100.72001043
71Shigellosis_Homo sapiens_hsa051310.70327860
72Autoimmune thyroid disease_Homo sapiens_hsa053200.70274898
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70037340
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69893421
75Long-term potentiation_Homo sapiens_hsa047200.69487160
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66746878
77Systemic lupus erythematosus_Homo sapiens_hsa053220.65892078
78MicroRNAs in cancer_Homo sapiens_hsa052060.64314492
79Complement and coagulation cascades_Homo sapiens_hsa046100.64273184
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63927468
81Allograft rejection_Homo sapiens_hsa053300.62496907
82Starch and sucrose metabolism_Homo sapiens_hsa005000.62069807
83Viral myocarditis_Homo sapiens_hsa054160.62002318
84Endocytosis_Homo sapiens_hsa041440.61123059
85Antigen processing and presentation_Homo sapiens_hsa046120.61015738
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.59577263
87GnRH signaling pathway_Homo sapiens_hsa049120.57268548
88Estrogen signaling pathway_Homo sapiens_hsa049150.57068382
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55812092
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55022790
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54720885
92HIF-1 signaling pathway_Homo sapiens_hsa040660.53846721
93Alcoholism_Homo sapiens_hsa050340.53451520
94Phagosome_Homo sapiens_hsa041450.52895581
95Salmonella infection_Homo sapiens_hsa051320.50809939
96Sphingolipid metabolism_Homo sapiens_hsa006000.49926060
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49845916
98Legionellosis_Homo sapiens_hsa051340.46799580
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46639295
100Type I diabetes mellitus_Homo sapiens_hsa049400.45437491

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