PPP4R4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.89070011
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76136640
3vocalization behavior (GO:0071625)4.73931908
4locomotory exploration behavior (GO:0035641)4.73207598
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.63402323
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56884504
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34421787
8glutamate receptor signaling pathway (GO:0007215)4.20448619
9regulation of glutamate receptor signaling pathway (GO:1900449)4.17948038
10retinal cone cell development (GO:0046549)4.15482061
11synaptic vesicle exocytosis (GO:0016079)4.14005287
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11843787
13glutamate secretion (GO:0014047)4.09881231
14synaptic vesicle maturation (GO:0016188)4.04535144
15neuronal action potential propagation (GO:0019227)4.02759891
16synaptic transmission, glutamatergic (GO:0035249)3.94742516
17regulation of synaptic vesicle exocytosis (GO:2000300)3.94348490
18neuron-neuron synaptic transmission (GO:0007270)3.93980834
19protein localization to synapse (GO:0035418)3.93652241
20exploration behavior (GO:0035640)3.92106101
21regulation of neuronal synaptic plasticity (GO:0048168)3.91524037
22neurotransmitter secretion (GO:0007269)3.88118817
23gamma-aminobutyric acid transport (GO:0015812)3.72423531
24sodium ion export (GO:0071436)3.70482941
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64681143
26regulation of synaptic vesicle transport (GO:1902803)3.62680578
27cerebellar granule cell differentiation (GO:0021707)3.60821357
28neuron cell-cell adhesion (GO:0007158)3.58129004
29behavioral response to cocaine (GO:0048148)3.58127182
30neurotransmitter-gated ion channel clustering (GO:0072578)3.57705524
31short-term memory (GO:0007614)3.57374049
32long-term memory (GO:0007616)3.51909945
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.50868837
34negative regulation of dendrite morphogenesis (GO:0050774)3.43420362
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.42184472
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.41464225
37L-amino acid import (GO:0043092)3.39350420
38transmission of nerve impulse (GO:0019226)3.37435645
39prepulse inhibition (GO:0060134)3.35827156
40regulation of female receptivity (GO:0045924)3.34110276
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32613498
42regulation of synapse structural plasticity (GO:0051823)3.31920942
43regulation of dendritic spine morphogenesis (GO:0061001)3.31600195
44regulation of postsynaptic membrane potential (GO:0060078)3.29459995
45regulation of synaptic plasticity (GO:0048167)3.26988087
46behavioral defense response (GO:0002209)3.25780855
47behavioral fear response (GO:0001662)3.25780855
48long-term synaptic potentiation (GO:0060291)3.23414976
49regulation of calcium ion-dependent exocytosis (GO:0017158)3.21378653
50neurotransmitter transport (GO:0006836)3.19911734
51cochlea development (GO:0090102)3.19865668
52dendritic spine morphogenesis (GO:0060997)3.16412988
53synaptic transmission, dopaminergic (GO:0001963)3.15017153
54positive regulation of membrane potential (GO:0045838)3.14339564
55response to histamine (GO:0034776)3.14323098
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13864969
57cellular potassium ion homeostasis (GO:0030007)3.13550272
58fear response (GO:0042596)3.12654372
59striatum development (GO:0021756)3.11352485
60neuron recognition (GO:0008038)3.10962355
61female mating behavior (GO:0060180)3.10864671
62cellular sodium ion homeostasis (GO:0006883)3.10270570
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.10080950
64cerebellar Purkinje cell layer development (GO:0021680)3.09855169
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09673527
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07570026
67proline transport (GO:0015824)3.07303210
68regulation of neurotransmitter levels (GO:0001505)3.06659357
69C4-dicarboxylate transport (GO:0015740)3.05874122
70synaptic vesicle endocytosis (GO:0048488)3.05633265
71positive regulation of synapse maturation (GO:0090129)3.00836379
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00502496
73membrane depolarization during action potential (GO:0086010)2.99078250
74neuromuscular process controlling posture (GO:0050884)2.98363111
75layer formation in cerebral cortex (GO:0021819)2.96755669
76regulation of glutamate secretion (GO:0014048)2.94537926
77long term synaptic depression (GO:0060292)2.93769845
78amino acid import (GO:0043090)2.92937296
79regulation of vesicle fusion (GO:0031338)2.92815458
80activation of protein kinase A activity (GO:0034199)2.92577026
81neuromuscular process controlling balance (GO:0050885)2.90952750
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90320439
83calcium ion-dependent exocytosis (GO:0017156)2.88440527
84mating behavior (GO:0007617)2.87539180
85membrane depolarization (GO:0051899)2.86663766
86learning (GO:0007612)2.84480816
87negative regulation of hormone biosynthetic process (GO:0032353)2.84279934
88response to amphetamine (GO:0001975)2.84162502
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83393783
90regulation of DNA methylation (GO:0044030)2.82858006
91regulation of acrosome reaction (GO:0060046)2.82269698
92innervation (GO:0060384)2.81269047
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81019939
94piRNA metabolic process (GO:0034587)2.78426064
95neuronal ion channel clustering (GO:0045161)2.78382742
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75586054
97regulation of meiosis I (GO:0060631)2.75344729
98chemosensory behavior (GO:0007635)2.73856445
99cerebellar Purkinje cell differentiation (GO:0021702)2.72776352
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71973414
101positive regulation of dendritic spine morphogenesis (GO:0061003)2.71238933
102L-phenylalanine catabolic process (GO:0006559)2.69621578
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69621578
104positive regulation of neurotransmitter transport (GO:0051590)2.69009342
105vesicle transport along microtubule (GO:0047496)2.68541341
106positive regulation of neurotransmitter secretion (GO:0001956)2.67715219
107dendritic spine organization (GO:0097061)2.66395890
108adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66198389
109synaptic transmission (GO:0007268)2.65925174
110axonal fasciculation (GO:0007413)2.65728627
111regulation of dendritic spine development (GO:0060998)2.65094571
112presynaptic membrane assembly (GO:0097105)2.64420432
113potassium ion homeostasis (GO:0055075)2.64297435
114nephron tubule morphogenesis (GO:0072078)2.63884546
115nephron epithelium morphogenesis (GO:0072088)2.63884546
116regulation of neurotransmitter secretion (GO:0046928)2.63587872
117detection of calcium ion (GO:0005513)2.62818217
118positive regulation of dendritic spine development (GO:0060999)2.61271149
119intraspecies interaction between organisms (GO:0051703)2.60746120
120social behavior (GO:0035176)2.60746120
121auditory behavior (GO:0031223)2.60471005
122presynaptic membrane organization (GO:0097090)2.60207463
123righting reflex (GO:0060013)2.60143502
124serotonin metabolic process (GO:0042428)2.58983441
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58489734
126positive regulation of meiosis (GO:0045836)2.55395952
127regulation of neurotransmitter transport (GO:0051588)2.53153179
128apical protein localization (GO:0045176)2.46294621
129protein localization to cilium (GO:0061512)2.44721387
130negative regulation of hormone metabolic process (GO:0032351)2.44363489
131cell communication involved in cardiac conduction (GO:0086065)2.43701926
132positive regulation of meiotic cell cycle (GO:0051446)2.39080899
133DNA methylation involved in gamete generation (GO:0043046)2.38625686
134primary amino compound metabolic process (GO:1901160)2.38088565
135acidic amino acid transport (GO:0015800)2.35018492
136phosphorelay signal transduction system (GO:0000160)2.34923272
137inner ear receptor cell development (GO:0060119)2.33522628
138synapsis (GO:0007129)2.32307044
139cell communication by electrical coupling (GO:0010644)2.31375212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.68894134
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.57083908
3GBX2_23144817_ChIP-Seq_PC3_Human3.44981880
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73732997
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71123428
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.61731164
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55011161
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.45973159
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33007011
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27339852
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27339852
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26358760
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25923975
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23840525
15DROSHA_22980978_ChIP-Seq_HELA_Human2.18396628
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15429253
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14525490
18TAF15_26573619_Chip-Seq_HEK293_Human2.04551110
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.01832529
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99863101
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.96329587
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95021651
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.92709846
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92103921
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87085052
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86236155
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85753924
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79707418
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.78544246
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76969397
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69789235
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.69628991
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59688826
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58816738
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54844387
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53523168
37AR_21572438_ChIP-Seq_LNCaP_Human1.52232260
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50857654
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.47401282
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46428282
41ZNF274_21170338_ChIP-Seq_K562_Hela1.41711061
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40351964
43P300_19829295_ChIP-Seq_ESCs_Human1.40037900
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39466493
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37981310
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37202262
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35916456
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.34560952
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32611812
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32346942
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.29537923
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29172786
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.25236932
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25069965
55STAT3_23295773_ChIP-Seq_U87_Human1.24791469
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24566438
57AR_25329375_ChIP-Seq_VCAP_Human1.22592200
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.22370545
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.20593331
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19417420
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17105910
62BCAT_22108803_ChIP-Seq_LS180_Human1.15563626
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15563084
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15355721
65SOX9_26525672_Chip-Seq_HEART_Mouse1.15344031
66VDR_22108803_ChIP-Seq_LS180_Human1.14902401
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14021163
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13694700
69LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12712592
70AR_19668381_ChIP-Seq_PC3_Human1.12446274
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.11733139
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10748102
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10216882
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10035485
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09846760
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.09752339
77* TCF4_23295773_ChIP-Seq_U87_Human1.09013063
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08438612
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.08133929
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08133820
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.07211523
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06863803
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06535588
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06010231
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05855736
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.04888204
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04844642
88FUS_26573619_Chip-Seq_HEK293_Human1.04498465
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.03414141
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03368221
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01217448
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01217448
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00902205
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00764755
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00758165
96RUNX2_22187159_ChIP-Seq_PCA_Human1.00650386
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.00127455
98HTT_18923047_ChIP-ChIP_STHdh_Human0.99635886
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99473728
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99322390
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99125424
102BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99074123
103IGF1R_20145208_ChIP-Seq_DFB_Human0.98618996
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97452950
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97112305
106TP53_16413492_ChIP-PET_HCT116_Human0.97059658
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.95016695
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.93906616
109AHR_22903824_ChIP-Seq_MCF-7_Human0.93756198
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93413795
111KDM2B_26808549_Chip-Seq_REH_Human0.92426487
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.92358763
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92162442
114CBP_20019798_ChIP-Seq_JUKART_Human0.92162442
115TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91669633
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91441844
117TP53_18474530_ChIP-ChIP_U2OS_Human0.90856137
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.89540754
119* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89084012
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88624572
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.88294271
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87852586
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.87377473
124RNF2_27304074_Chip-Seq_NSC_Mouse0.86987871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.92779214
2MP0003880_abnormal_central_pattern4.60470295
3MP0003635_abnormal_synaptic_transmissio3.87794060
4MP0002822_catalepsy3.68790817
5MP0009745_abnormal_behavioral_response3.44037185
6MP0004270_analgesia3.22812935
7MP0002063_abnormal_learning/memory/cond3.22319481
8MP0002064_seizures2.89023700
9MP0001968_abnormal_touch/_nociception2.81116175
10MP0008877_abnormal_DNA_methylation2.77650676
11MP0009046_muscle_twitch2.75383079
12MP0002572_abnormal_emotion/affect_behav2.69547913
13MP0002272_abnormal_nervous_system2.55034751
14MP0001501_abnormal_sleep_pattern2.54979715
15MP0001486_abnormal_startle_reflex2.31846071
16MP0002736_abnormal_nociception_after2.31677368
17MP0001440_abnormal_grooming_behavior2.19524283
18MP0005360_urolithiasis2.09333839
19MP0005423_abnormal_somatic_nervous2.05683520
20MP0002734_abnormal_mechanical_nocicepti2.04247905
21MP0002139_abnormal_hepatobiliary_system2.04091682
22MP0005085_abnormal_gallbladder_physiolo1.99659640
23MP0003329_amyloid_beta_deposits1.98316513
24MP0002735_abnormal_chemical_nociception1.91005867
25MP0009780_abnormal_chondrocyte_physiolo1.87627619
26MP0002909_abnormal_adrenal_gland1.86160238
27MP0008875_abnormal_xenobiotic_pharmacok1.75811121
28MP0002067_abnormal_sensory_capabilities1.75718917
29MP0005410_abnormal_fertilization1.72706242
30MP0005365_abnormal_bile_salt1.70501572
31MP0002733_abnormal_thermal_nociception1.70168519
32MP0003123_paternal_imprinting1.69835552
33MP0000566_synostosis1.69714987
34MP0003718_maternal_effect1.67283535
35MP0005646_abnormal_pituitary_gland1.66214993
36MP0005379_endocrine/exocrine_gland_phen1.65066552
37MP0005386_behavior/neurological_phenoty1.58286532
38MP0004924_abnormal_behavior1.58286532
39MP0002557_abnormal_social/conspecific_i1.57855839
40MP0001970_abnormal_pain_threshold1.56156286
41MP0006276_abnormal_autonomic_nervous1.56152228
42MP0001984_abnormal_olfaction1.51294957
43MP0001529_abnormal_vocalization1.48446063
44MP0002184_abnormal_innervation1.48193514
45MP0006292_abnormal_olfactory_placode1.47628872
46MP0002160_abnormal_reproductive_system1.47172179
47MP0002837_dystrophic_cardiac_calcinosis1.46142097
48MP0003890_abnormal_embryonic-extraembry1.43873466
49MP0003879_abnormal_hair_cell1.43527352
50MP0008569_lethality_at_weaning1.42088399
51MP0004811_abnormal_neuron_physiology1.39826760
52MP0003121_genomic_imprinting1.39272284
53MP0003633_abnormal_nervous_system1.34206227
54MP0008872_abnormal_physiological_respon1.34055569
55MP0010234_abnormal_vibrissa_follicle1.33206653
56MP0000778_abnormal_nervous_system1.32718434
57MP0000955_abnormal_spinal_cord1.27274415
58MP0002066_abnormal_motor_capabilities/c1.24689302
59MP0005535_abnormal_body_temperature1.19231440
60MP0010329_abnormal_lipoprotein_level1.19031424
61MP0002089_abnormal_postnatal_growth/wei1.18345483
62MP0004858_abnormal_nervous_system1.18110603
63MP0001346_abnormal_lacrimal_gland1.18097295
64MP0004885_abnormal_endolymph1.17727530
65MP0001502_abnormal_circadian_rhythm1.17360112
66MP0006072_abnormal_retinal_apoptosis1.14255044
67MP0001905_abnormal_dopamine_level1.14249887
68MP0003631_nervous_system_phenotype1.12679069
69MP0000604_amyloidosis1.10891650
70MP0002882_abnormal_neuron_morphology1.09776752
71MP0005389_reproductive_system_phenotype1.09388856
72MP0004142_abnormal_muscle_tone1.07598305
73MP0008874_decreased_physiological_sensi1.06599189
74MP0002254_reproductive_system_inflammat1.06293210
75MP0003252_abnormal_bile_duct1.05960536
76MP0005248_abnormal_Harderian_gland1.04260911
77MP0005645_abnormal_hypothalamus_physiol1.03583082
78MP0001944_abnormal_pancreas_morphology1.03297020
79MP0002069_abnormal_eating/drinking_beha0.99093268
80MP0002638_abnormal_pupillary_reflex0.98851900
81MP0003941_abnormal_skin_development0.97614053
82MP0004145_abnormal_muscle_electrophysio0.95992510
83MP0000013_abnormal_adipose_tissue0.93383114
84MP0001188_hyperpigmentation0.91281848
85MP0002876_abnormal_thyroid_physiology0.89145253
86MP0002152_abnormal_brain_morphology0.88842172
87MP0001929_abnormal_gametogenesis0.88391724
88MP0003787_abnormal_imprinting0.87609972
89MP0005551_abnormal_eye_electrophysiolog0.87464453
90MP0008789_abnormal_olfactory_epithelium0.86826684
91MP0000579_abnormal_nail_morphology0.86349862
92MP0001177_atelectasis0.86173965
93MP0002234_abnormal_pharynx_morphology0.86071163
94MP0003195_calcinosis0.85989563
95MP0005187_abnormal_penis_morphology0.85796715
96MP0001299_abnormal_eye_distance/0.85447273
97MP0004043_abnormal_pH_regulation0.85038429
98MP0003136_yellow_coat_color0.84935927
99MP0005332_abnormal_amino_acid0.84161425
100MP0004085_abnormal_heartbeat0.83279150
101MP0002229_neurodegeneration0.83140499
102MP0001485_abnormal_pinna_reflex0.82008603
103MP0002210_abnormal_sex_determination0.81235652
104MP0002161_abnormal_fertility/fecundity0.80599731
105MP0000427_abnormal_hair_cycle0.80558642
106MP0003632_abnormal_nervous_system0.79757851
107MP0010678_abnormal_skin_adnexa0.78795369
108MP0005409_darkened_coat_color0.78233699
109MP0005083_abnormal_biliary_tract0.77540455
110MP0003690_abnormal_glial_cell0.77418152
111MP0003075_altered_response_to0.75349952
112MP0002163_abnormal_gland_morphology0.75327507
113MP0006035_abnormal_mitochondrial_morpho0.75282107
114MP0008961_abnormal_basal_metabolism0.72620283
115MP0001963_abnormal_hearing_physiology0.71639946
116MP0001765_abnormal_ion_homeostasis0.70856444
117MP0003119_abnormal_digestive_system0.69801507
118MP0005499_abnormal_olfactory_system0.68907750
119MP0005394_taste/olfaction_phenotype0.68907750
120MP0000653_abnormal_sex_gland0.68838302
121MP0003283_abnormal_digestive_organ0.67340896
122MP0003698_abnormal_male_reproductive0.67210832
123MP0002090_abnormal_vision0.66864585
124MP0002118_abnormal_lipid_homeostasis0.64552390
125MP0003122_maternal_imprinting0.64304759
126MP0003868_abnormal_feces_composition0.59872251
127MP0005167_abnormal_blood-brain_barrier0.58652264
128MP0000631_abnormal_neuroendocrine_gland0.58245630
129MP0004742_abnormal_vestibular_system0.58104300
130MP0001664_abnormal_digestion0.58008867
131MP0010386_abnormal_urinary_bladder0.57951266
132MP0001666_abnormal_nutrient_absorption0.57888672
133MP0002078_abnormal_glucose_homeostasis0.54643972

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.38927000
2Myokymia (HP:0002411)5.91343616
3Focal seizures (HP:0007359)5.13810212
4Visual hallucinations (HP:0002367)4.49042394
5Hyperventilation (HP:0002883)4.21762561
6Atonic seizures (HP:0010819)4.17810052
7Epileptic encephalopathy (HP:0200134)3.97837818
8Absence seizures (HP:0002121)3.97485916
9Febrile seizures (HP:0002373)3.86299559
10Progressive cerebellar ataxia (HP:0002073)3.70460643
11Generalized tonic-clonic seizures (HP:0002069)3.62304698
12Dialeptic seizures (HP:0011146)3.61926877
13Action tremor (HP:0002345)3.60588977
14Abnormality of the lower motor neuron (HP:0002366)3.37422603
15Dysdiadochokinesis (HP:0002075)3.24762518
16Gaze-evoked nystagmus (HP:0000640)3.23575158
17Supernumerary spleens (HP:0009799)3.23563713
18Cerebral inclusion bodies (HP:0100314)3.22313265
19Central scotoma (HP:0000603)3.17117370
20Broad-based gait (HP:0002136)3.10222596
21Status epilepticus (HP:0002133)3.06897472
22Dysmetria (HP:0001310)3.04706201
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.03161007
24Absent/shortened dynein arms (HP:0200106)3.03161007
25Poor eye contact (HP:0000817)2.98228015
26Impaired vibration sensation in the lower limbs (HP:0002166)2.96114597
27Impaired social interactions (HP:0000735)2.95834110
28Abnormal social behavior (HP:0012433)2.95834110
29Anxiety (HP:0000739)2.93039454
30Neurofibrillary tangles (HP:0002185)2.92371875
31Supranuclear gaze palsy (HP:0000605)2.85495696
32Scanning speech (HP:0002168)2.83216241
33Depression (HP:0000716)2.80711566
34Truncal ataxia (HP:0002078)2.77433574
35Impaired smooth pursuit (HP:0007772)2.71491660
36Amblyopia (HP:0000646)2.70451365
37Postural instability (HP:0002172)2.68878451
38Epileptiform EEG discharges (HP:0011182)2.67943894
39Excessive salivation (HP:0003781)2.65126661
40Drooling (HP:0002307)2.65126661
41Intention tremor (HP:0002080)2.60887136
42Deep venous thrombosis (HP:0002625)2.58782144
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57387829
44Hemiparesis (HP:0001269)2.54787296
45EEG with generalized epileptiform discharges (HP:0011198)2.51657921
46Postural tremor (HP:0002174)2.48900092
47Septo-optic dysplasia (HP:0100842)2.48312142
48Dysmetric saccades (HP:0000641)2.47115680
49Hypoplasia of the fovea (HP:0007750)2.46552554
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.46552554
51Torticollis (HP:0000473)2.45304332
52Abnormality of ocular smooth pursuit (HP:0000617)2.44849186
53Focal dystonia (HP:0004373)2.38743402
54Hypsarrhythmia (HP:0002521)2.37096648
55Urinary bladder sphincter dysfunction (HP:0002839)2.36229533
56Horizontal nystagmus (HP:0000666)2.36092920
57Posterior subcapsular cataract (HP:0007787)2.34545968
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34406594
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.34406594
60Bradykinesia (HP:0002067)2.33842889
61Male infertility (HP:0003251)2.31681365
62Impaired vibratory sensation (HP:0002495)2.31539002
63Abnormal eating behavior (HP:0100738)2.29073016
64Prolonged partial thromboplastin time (HP:0003645)2.27481675
65Scotoma (HP:0000575)2.24974484
66Annular pancreas (HP:0001734)2.24005746
67Abnormality of the labia minora (HP:0012880)2.23222161
68Absent speech (HP:0001344)2.23098223
69Craniofacial dystonia (HP:0012179)2.21327706
70Limb dystonia (HP:0002451)2.19157476
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18551120
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18401713
73Spontaneous abortion (HP:0005268)2.18206568
74Spastic gait (HP:0002064)2.15913375
75Abnormal gallbladder physiology (HP:0012438)2.15291551
76Cholecystitis (HP:0001082)2.15291551
77Optic nerve hypoplasia (HP:0000609)2.13308594
78Global brain atrophy (HP:0002283)2.13031697
79Abnormal respiratory motile cilium physiology (HP:0012261)2.10400080
80Genetic anticipation (HP:0003743)2.05929752
81Hypobetalipoproteinemia (HP:0003563)2.05569515
82Blue irides (HP:0000635)2.04764049
83Confusion (HP:0001289)2.04176521
84Abnormality of the fovea (HP:0000493)2.04174683
85Insidious onset (HP:0003587)2.03475362
86Termporal pattern (HP:0011008)2.03475362
87Oligodactyly (hands) (HP:0001180)2.03465540
88Ankle clonus (HP:0011448)2.02903440
89Abnormality of binocular vision (HP:0011514)2.02404356
90Diplopia (HP:0000651)2.02404356
91Urinary urgency (HP:0000012)2.02363921
92Resting tremor (HP:0002322)2.01632365
93Abdominal situs inversus (HP:0003363)2.01548201
94Abnormality of abdominal situs (HP:0011620)2.01548201
95Delusions (HP:0000746)2.01239495
96Stereotypic behavior (HP:0000733)2.00163849
97Infertility (HP:0000789)1.99903665
98Intrahepatic cholestasis (HP:0001406)1.99901061
99Generalized myoclonic seizures (HP:0002123)1.99480252
100Abnormality of the corticospinal tract (HP:0002492)1.96416134
101Fair hair (HP:0002286)1.96065118
102Abnormal ciliary motility (HP:0012262)1.95817094
103Gait ataxia (HP:0002066)1.95738441
104Osteomalacia (HP:0002749)1.95229794
105Complement deficiency (HP:0004431)1.92306196
106Hypoglycemic coma (HP:0001325)1.89184707
107Enlarged penis (HP:0000040)1.89173635
108Abnormal respiratory epithelium morphology (HP:0012253)1.86564140
109Abnormal respiratory motile cilium morphology (HP:0005938)1.86564140
110Urethral obstruction (HP:0000796)1.86487414
111Protruding tongue (HP:0010808)1.86409278
112Papillary thyroid carcinoma (HP:0002895)1.86191331
113Progressive inability to walk (HP:0002505)1.84833237
114Amyotrophic lateral sclerosis (HP:0007354)1.82269624
115Ketosis (HP:0001946)1.82146538
116Hemiplegia (HP:0002301)1.82007639
117Hydroureter (HP:0000072)1.81942194
118Abnormality of macular pigmentation (HP:0008002)1.81594934
119Psychosis (HP:0000709)1.81351895
120Gait imbalance (HP:0002141)1.80551183
121Clonus (HP:0002169)1.80413078
122Mutism (HP:0002300)1.78408640
123Neuronal loss in central nervous system (HP:0002529)1.78287822
124Inability to walk (HP:0002540)1.78163707
125Abnormality of saccadic eye movements (HP:0000570)1.78146735
126Hypophosphatemic rickets (HP:0004912)1.76927921
127Retinal atrophy (HP:0001105)1.76474880
128Absent septum pellucidum (HP:0001331)1.75362643
129Hyperlipoproteinemia (HP:0010980)1.73605329
130Chromsome breakage (HP:0040012)1.73596512
131Tetraplegia (HP:0002445)1.73253247
132Sensory axonal neuropathy (HP:0003390)1.73236360
133Pheochromocytoma (HP:0002666)1.71420702
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67521936
135Rhinitis (HP:0012384)1.67395556
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65971034
137Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.65745025
138Megaloblastic anemia (HP:0001889)1.64949404
139Azoospermia (HP:0000027)1.64780043
140Subcapsular cataract (HP:0000523)1.62571246
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60919258
142Medial flaring of the eyebrow (HP:0010747)1.59688379
143Intestinal atresia (HP:0011100)1.58852621
144Genital tract atresia (HP:0001827)1.57938541
145Hyperinsulinemic hypoglycemia (HP:0000825)1.57166576
146Limb ataxia (HP:0002070)1.56572443
147Congenital primary aphakia (HP:0007707)1.54916662
148Median cleft lip (HP:0000161)1.54414313
149Tubulointerstitial nephritis (HP:0001970)1.52728534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.53014808
2NTRK34.67394559
3MAP3K93.37606431
4RIPK43.01672250
5MAP3K42.96408498
6EEF2K2.56124645
7MAP2K42.51320922
8MINK12.38675123
9MAP2K72.31741771
10KSR22.25521699
11DAPK22.22325530
12PRKD32.14502919
13STK242.07786069
14FGFR21.92512578
15PNCK1.92056576
16TTK1.82823338
17NTRK11.77693884
18LMTK21.73534813
19PAK61.71682291
20CASK1.69664077
21KSR11.62888423
22STK38L1.61493445
23CAMKK11.60824908
24STK381.57773708
25DAPK11.54660548
26ARAF1.53837408
27MARK11.52834386
28MAP3K121.51941419
29PTK2B1.51641854
30MAP3K131.49926128
31NTRK21.49531470
32MAP3K21.40662350
33PDK31.38404459
34PDK41.38404459
35MAPKAPK31.37722526
36GRK51.37504379
37CDK51.37196820
38PRKCG1.33779388
39BMPR21.30358760
40PLK21.29036659
41CSNK1G11.26246222
42FES1.20340709
43SIK21.18195999
44PLK31.17702929
45BRD41.15634517
46MET1.14087768
47CAMK2A1.13104050
48CAMK2B1.10983184
49MST41.09101664
50CAMKK21.01923029
51BRSK11.00080601
52PRPF4B0.99717654
53STK30.96384831
54MAPKAPK50.95437898
55CSNK1G30.93800144
56TYRO30.93458375
57SGK4940.92022206
58SGK2230.92022206
59PINK10.89733593
60TNIK0.88595262
61RAF10.87473266
62WNK30.86412619
63PRKG20.85380952
64SGK20.83825919
65PDK20.83665382
66TRPM70.83522302
67RET0.82596172
68PDPK10.77029871
69FER0.74471023
70PTK20.74381124
71SGK30.74283272
72NME10.73434773
73MAP3K10.73407282
74SGK10.73378826
75CSNK1E0.72772205
76PDK10.72399746
77TSSK60.71703462
78CAMK10.71574399
79CSNK1A1L0.71487120
80UHMK10.70502702
81WNK10.68731093
82FRK0.68500259
83PRKCI0.67990855
84CDC70.67593528
85AKT30.67277989
86CAMK2G0.66558817
87LATS20.66209652
88LATS10.65630777
89PRKG10.64004487
90DYRK1A0.63642727
91FGR0.63332123
92CAMK2D0.63178861
93MAP3K70.62157770
94PLK10.62150795
95CDK180.61343091
96PRKCZ0.60780579
97STK110.60250834
98INSRR0.60151826
99CDK150.59965537
100MAP2K10.59167629
101CDK140.58846016
102PAK30.58838603
103CSNK1D0.58346659
104TNK20.58164560
105PRKCH0.57937964
106MOS0.57191516
107MAPK130.56488663
108FGFR10.55294357
109PHKG10.54672283
110ZAK0.54495821
111WNK40.53173850
112CSNK1G20.52876057
113CAMK1G0.52333993
114BCR0.51920593
115PRKCE0.51876539
116BRAF0.51415523
117FGFR30.50312160
118CDK11A0.49170403
119RPS6KA30.49082221
120MARK20.47815413
121EIF2AK30.47728845
122STK390.47209923
123YES10.46851366
124RPS6KB10.46439595
125TAF10.44504960
126RIPK10.43966428
127MAPK100.43880363
128CAMK40.43747039
129NEK60.42731150
130MAP3K60.41351311
131OXSR10.38987307
132GRK70.38334394
133CDK190.37588029
134PRKACA0.37552915
135PRKCB0.35949945
136GRK60.35690593
137FYN0.35444565
138PHKG20.33259961

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67952879
2Long-term potentiation_Homo sapiens_hsa047202.65736106
3Vitamin B6 metabolism_Homo sapiens_hsa007502.62486317
4Amphetamine addiction_Homo sapiens_hsa050312.58883596
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50023434
6Synaptic vesicle cycle_Homo sapiens_hsa047212.48083252
7GABAergic synapse_Homo sapiens_hsa047272.43860373
8Circadian entrainment_Homo sapiens_hsa047132.41416055
9Nitrogen metabolism_Homo sapiens_hsa009102.41258727
10Glutamatergic synapse_Homo sapiens_hsa047242.36224612
11Morphine addiction_Homo sapiens_hsa050322.20431865
12Olfactory transduction_Homo sapiens_hsa047402.11618809
13Salivary secretion_Homo sapiens_hsa049701.97403383
14Dopaminergic synapse_Homo sapiens_hsa047281.96041617
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91104008
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83973491
17Insulin secretion_Homo sapiens_hsa049111.82368249
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.80030651
19Taste transduction_Homo sapiens_hsa047421.72923575
20Renin secretion_Homo sapiens_hsa049241.70701057
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69170403
22Cocaine addiction_Homo sapiens_hsa050301.67499507
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61678087
24Arginine biosynthesis_Homo sapiens_hsa002201.53212132
25Gastric acid secretion_Homo sapiens_hsa049711.52337088
26Long-term depression_Homo sapiens_hsa047301.50652320
27Folate biosynthesis_Homo sapiens_hsa007901.49379446
28Calcium signaling pathway_Homo sapiens_hsa040201.48088023
29Cholinergic synapse_Homo sapiens_hsa047251.43396932
30Serotonergic synapse_Homo sapiens_hsa047261.36258107
31Bile secretion_Homo sapiens_hsa049761.31662218
32Oxytocin signaling pathway_Homo sapiens_hsa049211.30641599
33Collecting duct acid secretion_Homo sapiens_hsa049661.27041848
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26043811
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21103978
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13246546
37cAMP signaling pathway_Homo sapiens_hsa040241.11036686
38GnRH signaling pathway_Homo sapiens_hsa049121.11036062
39Type II diabetes mellitus_Homo sapiens_hsa049301.10524863
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05349442
41Butanoate metabolism_Homo sapiens_hsa006501.01729237
42Gap junction_Homo sapiens_hsa045401.00130754
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94430706
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94260965
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93890335
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93519323
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92588963
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92575694
49Glucagon signaling pathway_Homo sapiens_hsa049220.91866274
50Estrogen signaling pathway_Homo sapiens_hsa049150.91663427
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91390738
52Pancreatic secretion_Homo sapiens_hsa049720.87504218
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83261770
54Fatty acid elongation_Homo sapiens_hsa000620.80727620
55Basal transcription factors_Homo sapiens_hsa030220.80567125
56Thyroid hormone synthesis_Homo sapiens_hsa049180.80152518
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.77766933
58Complement and coagulation cascades_Homo sapiens_hsa046100.77487112
59Melanogenesis_Homo sapiens_hsa049160.76744004
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76377455
61Dorso-ventral axis formation_Homo sapiens_hsa043200.75397243
62Arginine and proline metabolism_Homo sapiens_hsa003300.73950212
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73431085
64Mismatch repair_Homo sapiens_hsa034300.73271598
65Tight junction_Homo sapiens_hsa045300.71294720
66Cardiac muscle contraction_Homo sapiens_hsa042600.69353248
67Protein export_Homo sapiens_hsa030600.69275321
68Hippo signaling pathway_Homo sapiens_hsa043900.67689122
69Wnt signaling pathway_Homo sapiens_hsa043100.65857942
70Glioma_Homo sapiens_hsa052140.65841960
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65169870
72Vibrio cholerae infection_Homo sapiens_hsa051100.64393815
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63759506
74Steroid biosynthesis_Homo sapiens_hsa001000.62992894
75Tryptophan metabolism_Homo sapiens_hsa003800.62761642
76Oxidative phosphorylation_Homo sapiens_hsa001900.61746896
77Pyruvate metabolism_Homo sapiens_hsa006200.61689430
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59952878
79Oocyte meiosis_Homo sapiens_hsa041140.58498235
80Axon guidance_Homo sapiens_hsa043600.57269203
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57191982
82Selenocompound metabolism_Homo sapiens_hsa004500.56824471
83Glycerolipid metabolism_Homo sapiens_hsa005610.56076269
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55178556
85Prion diseases_Homo sapiens_hsa050200.54320433
86Fatty acid biosynthesis_Homo sapiens_hsa000610.54058075
87PPAR signaling pathway_Homo sapiens_hsa033200.52712975
88Chemical carcinogenesis_Homo sapiens_hsa052040.51474003
89ErbB signaling pathway_Homo sapiens_hsa040120.50820270
90Cell cycle_Homo sapiens_hsa041100.50440123
91Propanoate metabolism_Homo sapiens_hsa006400.50077346
92Circadian rhythm_Homo sapiens_hsa047100.49469887
93Choline metabolism in cancer_Homo sapiens_hsa052310.48612383
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48490172
95Phototransduction_Homo sapiens_hsa047440.48334877
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47722143
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47225225
98Ovarian steroidogenesis_Homo sapiens_hsa049130.46287716
99Huntingtons disease_Homo sapiens_hsa050160.46263432
100mRNA surveillance pathway_Homo sapiens_hsa030150.44774188
101Fatty acid degradation_Homo sapiens_hsa000710.44312644
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.44292297
103beta-Alanine metabolism_Homo sapiens_hsa004100.44138338
104Histidine metabolism_Homo sapiens_hsa003400.44034224
105Hedgehog signaling pathway_Homo sapiens_hsa043400.42347087
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42311009
107Sphingolipid metabolism_Homo sapiens_hsa006000.41313549
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40778227
109African trypanosomiasis_Homo sapiens_hsa051430.40698748
110Mineral absorption_Homo sapiens_hsa049780.40630903
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39374622
112Alcoholism_Homo sapiens_hsa050340.39309211
113Phenylalanine metabolism_Homo sapiens_hsa003600.39239535
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37960651
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37811815
116Alzheimers disease_Homo sapiens_hsa050100.37479693
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37469039
118Regulation of autophagy_Homo sapiens_hsa041400.37307714
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.37172697
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.36689660
121Sulfur metabolism_Homo sapiens_hsa009200.35417650
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.35057178
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34993995
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.34781367
125Fatty acid metabolism_Homo sapiens_hsa012120.34762193
126ABC transporters_Homo sapiens_hsa020100.34123643
127MAPK signaling pathway_Homo sapiens_hsa040100.33009846
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32614454
129Peroxisome_Homo sapiens_hsa041460.31041020
130Inositol phosphate metabolism_Homo sapiens_hsa005620.29966709

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