PPP6C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T cell chemotaxis (GO:0010819)7.08095776
2positive regulation of T cell chemotaxis (GO:0010820)7.08095776
3production of molecular mediator involved in inflammatory response (GO:0002532)6.46630676
4G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.36445512
5Golgi to endosome transport (GO:0006895)5.61434709
6cellular response to interferon-beta (GO:0035458)5.52921842
7negative regulation of fibroblast apoptotic process (GO:2000270)5.22481461
8positive regulation of T cell migration (GO:2000406)4.93263472
9platelet dense granule organization (GO:0060155)4.91676269
10regulation of fibroblast apoptotic process (GO:2000269)4.91395158
11nuclear pore organization (GO:0006999)4.59477965
12regulation of lymphocyte chemotaxis (GO:1901623)4.57007923
13mitotic cell cycle arrest (GO:0071850)4.51503629
14vesicle fusion (GO:0006906)4.49120139
15response to interferon-beta (GO:0035456)4.31421093
16mitotic metaphase plate congression (GO:0007080)4.25178205
17negative regulation of phagocytosis (GO:0050765)4.24749954
18regulation of T cell migration (GO:2000404)4.23805169
19positive regulation of lymphocyte migration (GO:2000403)4.22165072
20protein deneddylation (GO:0000338)4.06739977
21gonadal mesoderm development (GO:0007506)4.02301497
22signal peptide processing (GO:0006465)4.00391343
23protein localization to kinetochore (GO:0034501)3.92286310
24negative regulation of T-helper cell differentiation (GO:0045623)3.85316449
25negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.85316449
26protein localization to chromosome, centromeric region (GO:0071459)3.83845677
27mitotic sister chromatid cohesion (GO:0007064)3.83334459
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77375407
29metaphase plate congression (GO:0051310)3.74664892
30establishment of chromosome localization (GO:0051303)3.73918031
31IMP metabolic process (GO:0046040)3.72172073
32N-terminal protein amino acid acetylation (GO:0006474)3.71085325
33IMP biosynthetic process (GO:0006188)3.70211910
34mitochondrion distribution (GO:0048311)3.65876147
35negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.64003860
36CENP-A containing nucleosome assembly (GO:0034080)3.63954004
37negative regulation of systemic arterial blood pressure (GO:0003085)3.59941984
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.57963909
39chromatin remodeling at centromere (GO:0031055)3.52740688
40G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.48977455
41negative regulation of execution phase of apoptosis (GO:1900118)3.42131755
42definitive hemopoiesis (GO:0060216)3.41715026
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41066283
44mitotic spindle checkpoint (GO:0071174)3.40613434
45regulation of cellular respiration (GO:0043457)3.38711760
46spindle checkpoint (GO:0031577)3.36985433
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.36855729
48negative regulation of sister chromatid segregation (GO:0033046)3.36855729
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36855729
50negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36855729
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36855729
52regulation of Golgi to plasma membrane protein transport (GO:0042996)3.35087486
53superoxide anion generation (GO:0042554)3.33005352
54negative regulation of activin receptor signaling pathway (GO:0032926)3.32555292
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32521491
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32521491
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30678889
58sequestering of actin monomers (GO:0042989)3.30365600
59positive regulation of mitochondrial fission (GO:0090141)3.30168509
60regulation of lymphocyte migration (GO:2000401)3.29153258
61cytochrome complex assembly (GO:0017004)3.26744614
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26521171
63regulation of mitotic sister chromatid separation (GO:0010965)3.25818454
64regulation of mitotic sister chromatid segregation (GO:0033047)3.25818454
65regulation of sister chromatid segregation (GO:0033045)3.25818454
66spermatid nucleus differentiation (GO:0007289)3.25523533
67negative regulation of chromosome segregation (GO:0051985)3.24887466
68formation of translation preinitiation complex (GO:0001731)3.24130459
69mitotic spindle assembly checkpoint (GO:0007094)3.22996645
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.22968722
71spindle assembly checkpoint (GO:0071173)3.22149205
72ribosome assembly (GO:0042255)3.15720395
73DNA double-strand break processing (GO:0000729)3.14120620
74DNA replication-independent nucleosome assembly (GO:0006336)3.06586325
75DNA replication-independent nucleosome organization (GO:0034724)3.06586325
76autophagic vacuole fusion (GO:0000046)3.06087087
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.05356989
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05356989
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05356989
80folic acid-containing compound biosynthetic process (GO:0009396)3.03612100
81hydrogen peroxide biosynthetic process (GO:0050665)3.03581364
82purine nucleobase biosynthetic process (GO:0009113)3.02076962
83AMP metabolic process (GO:0046033)3.01290509
84response to increased oxygen levels (GO:0036296)3.00645316
85response to hyperoxia (GO:0055093)3.00645316
86histamine secretion (GO:0001821)3.00198809
87regulation of chromosome segregation (GO:0051983)2.99464040
88establishment of integrated proviral latency (GO:0075713)2.98768546
89transcription from RNA polymerase I promoter (GO:0006360)2.98564381
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93768635
91regulation of germinal center formation (GO:0002634)2.92232449
92myeloid dendritic cell activation (GO:0001773)2.90621237
93misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.89694306
94intracellular pH reduction (GO:0051452)2.89591842
95ether lipid metabolic process (GO:0046485)2.89317869
96positive regulation of chromosome segregation (GO:0051984)2.88471758
97purine nucleotide salvage (GO:0032261)2.87905348
98regulation of meiosis I (GO:0060631)2.87715431
99sister chromatid segregation (GO:0000819)2.86299734
100histone exchange (GO:0043486)2.85827123
101antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84341635
102proteasome assembly (GO:0043248)2.84341245
103T-helper cell differentiation (GO:0042093)2.84070554
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.84070554
105negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83874314
106negative regulation of ligase activity (GO:0051352)2.83874314
107nuclear pore complex assembly (GO:0051292)2.83860648
108mitotic G2/M transition checkpoint (GO:0044818)2.83339313
109mitotic nuclear envelope disassembly (GO:0007077)2.83270105
110lactate metabolic process (GO:0006089)2.83230135
111protein neddylation (GO:0045116)2.79751682
112attachment of spindle microtubules to kinetochore (GO:0008608)2.79454419
113membrane budding (GO:0006900)2.79450230
114reactive oxygen species biosynthetic process (GO:1903409)2.77825042
115mitotic sister chromatid segregation (GO:0000070)2.77664368
116mitotic chromosome condensation (GO:0007076)2.77109790
117hepatocyte apoptotic process (GO:0097284)2.76794016
118cyclooxygenase pathway (GO:0019371)2.76562104
119non-recombinational repair (GO:0000726)2.75653894
120double-strand break repair via nonhomologous end joining (GO:0006303)2.75653894
121Notch receptor processing (GO:0007220)2.73586317
122synapsis (GO:0007129)2.73102338
123protein refolding (GO:0042026)2.72776766
124protein homotrimerization (GO:0070207)2.71169836
125protein localization to chromosome (GO:0034502)2.70488929
126antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.70344453
127purine-containing compound salvage (GO:0043101)2.70145229
128protein localization to microtubule (GO:0035372)2.69740735
129nuclear envelope disassembly (GO:0051081)2.69228265
130membrane disassembly (GO:0030397)2.69228265
131mitotic G2 DNA damage checkpoint (GO:0007095)2.68138185
132daunorubicin metabolic process (GO:0044597)2.67882543
133polyketide metabolic process (GO:0030638)2.67882543
134doxorubicin metabolic process (GO:0044598)2.67882543
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67610793
136L-fucose metabolic process (GO:0042354)2.67054354
137L-fucose catabolic process (GO:0042355)2.67054354
138fucose catabolic process (GO:0019317)2.67054354
139negative regulation of proteasomal protein catabolic process (GO:1901799)2.66805419
140positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66309051
141DNA catabolic process, exonucleolytic (GO:0000738)2.65750712
142regulation of mitotic spindle checkpoint (GO:1903504)2.65433751
143regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65433751
144negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.64856090
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.64725035
146transcription initiation from RNA polymerase I promoter (GO:0006361)2.63569827
147endosome to pigment granule transport (GO:0043485)2.62923391
148endosome to melanosome transport (GO:0035646)2.62923391
149tricarboxylic acid cycle (GO:0006099)2.62812056
150termination of RNA polymerase I transcription (GO:0006363)2.61179168
151protein K11-linked ubiquitination (GO:0070979)2.61035779
152ribonucleoprotein complex disassembly (GO:0032988)2.60743078
153neutrophil activation involved in immune response (GO:0002283)2.60429914
154activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.60145814
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58820757
156regulation of ubiquitin-protein transferase activity (GO:0051438)2.58790575
157positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58701213
158positive regulation of ligase activity (GO:0051351)2.58418415
159organelle disassembly (GO:1903008)2.57475617
160positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.57279544
161multi-organism transport (GO:0044766)2.57258596
162multi-organism localization (GO:1902579)2.57258596
163multi-organism intracellular transport (GO:1902583)2.57258596
164transport of virus (GO:0046794)2.57258596
165intracellular transport of virus (GO:0075733)2.57258596
166regulation of cofactor metabolic process (GO:0051193)2.56348178
167regulation of coenzyme metabolic process (GO:0051196)2.56348178
168oxidative phosphorylation (GO:0006119)2.56316766
169membrane protein ectodomain proteolysis (GO:0006509)2.54444160
170cullin deneddylation (GO:0010388)2.54092174
171negative regulation of DNA recombination (GO:0045910)2.53666500
172* cell cycle G1/S phase transition (GO:0044843)2.53466587
173* G1/S transition of mitotic cell cycle (GO:0000082)2.53466587
174regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.53032189
175metallo-sulfur cluster assembly (GO:0031163)2.52697881
176iron-sulfur cluster assembly (GO:0016226)2.52697881
177protein peptidyl-prolyl isomerization (GO:0000413)2.52148177
178mitochondrial calcium ion homeostasis (GO:0051560)2.50955717
179pore complex assembly (GO:0046931)2.49626666
180regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.49094387
181negative regulation of alpha-beta T cell differentiation (GO:0046639)2.48891206
182transcription elongation from RNA polymerase I promoter (GO:0006362)2.48826103
183regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.48723645
184mitochondrial RNA metabolic process (GO:0000959)2.47121425
185positive regulation of vasculogenesis (GO:2001214)2.46127274
186alpha-beta T cell activation involved in immune response (GO:0002287)2.46105135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.33196494
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.46358588
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.36173713
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.34506036
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.13608477
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12145049
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04250994
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.75700002
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75408221
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.74160717
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72707227
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60410949
13ELK1_19687146_ChIP-ChIP_HELA_Human2.57019984
14TAF15_26573619_Chip-Seq_HEK293_Human2.36657211
15HOXB4_20404135_ChIP-ChIP_EML_Mouse2.32823361
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32704442
17* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.30172918
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29085078
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20174157
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20091509
21* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.15984965
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.12227208
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11136348
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.09421927
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07920541
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.06682199
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04974708
28* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04837517
29* SRF_21415370_ChIP-Seq_HL-1_Mouse2.04507771
30GATA2_21666600_ChIP-Seq_HMVEC_Human2.02753478
31POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01057159
32* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98694311
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94804771
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.93563222
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90136391
36E2F7_22180533_ChIP-Seq_HELA_Human1.84379039
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82826264
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81425509
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80386750
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78048583
41DCP1A_22483619_ChIP-Seq_HELA_Human1.77052202
42TFEB_21752829_ChIP-Seq_HELA_Human1.75560095
43IRF1_19129219_ChIP-ChIP_H3396_Human1.69886113
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69801350
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.68507829
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.66502736
47* VDR_23849224_ChIP-Seq_CD4+_Human1.65855759
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65138786
49* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64532266
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63831747
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62023030
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61730149
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61218972
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60651022
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60261973
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.56292483
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53386266
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51030659
59* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48396239
60* ETS1_20019798_ChIP-Seq_JURKAT_Human1.47367113
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47251406
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46695296
63* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45088577
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44477303
65* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43574620
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41840969
67GBX2_23144817_ChIP-Seq_PC3_Human1.40471029
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37978803
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34742634
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33766420
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33766420
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33743706
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31956672
74* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30802064
75SCL_19346495_ChIP-Seq_HPC-7_Human1.30279173
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30193940
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29607493
78SPI1_23547873_ChIP-Seq_NB4_Human1.29508220
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28956964
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.28908563
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.28560308
82P300_19829295_ChIP-Seq_ESCs_Human1.26897378
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26651224
84MYC_18555785_ChIP-Seq_MESCs_Mouse1.26539142
85GATA1_22025678_ChIP-Seq_K562_Human1.26333331
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24266499
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23550142
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22050972
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21918036
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20733530
91TTF2_22483619_ChIP-Seq_HELA_Human1.19613432
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18520735
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18261995
94FUS_26573619_Chip-Seq_HEK293_Human1.16998476
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.16599695
96* GABP_19822575_ChIP-Seq_HepG2_Human1.16598332
97VDR_22108803_ChIP-Seq_LS180_Human1.16493183
98* SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16116953
99* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14714491
100GATA3_26560356_Chip-Seq_TH2_Human1.13344472
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12927580
102AR_21909140_ChIP-Seq_LNCAP_Human1.12860313
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12345796
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12345796
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12345796
106* STAT3_18555785_Chip-Seq_ESCs_Mouse1.11104813
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10928209
108RUNX_20019798_ChIP-Seq_JUKART_Human1.08557990
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08051384
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07904047
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.07788149
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07780181
113CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07324094
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07252730
115* NMYC_18555785_Chip-Seq_ESCs_Mouse1.05379975
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04793145
117* P53_22387025_ChIP-Seq_ESCs_Mouse1.04519775
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02716658
119* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02279190
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01551864
121EWS_26573619_Chip-Seq_HEK293_Human1.00482320
122MYB_26560356_Chip-Seq_TH2_Human0.99315641
123* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98267692
124* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98089934
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.96447488
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96284907
127IGF1R_20145208_ChIP-Seq_DFB_Human0.95967932
128* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95708722
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95652996
130* SOX17_20123909_ChIP-Seq_XEN_Mouse0.95549600
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95349691
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94306559
133EGR1_19374776_ChIP-ChIP_THP-1_Human0.94162256
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.92499477
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92022345
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91853190
137* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91083208
138SALL4_22934838_ChIP-ChIP_CD34+_Human0.90652440
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90471501
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89690613
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89375562
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88465510
143CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87976980
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87434091
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87154615
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86309961
147MYB_26560356_Chip-Seq_TH1_Human0.85168077
148ELF5_23300383_ChIP-Seq_T47D_Human0.84672281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism7.12010296
2MP0001545_abnormal_hematopoietic_system4.12579128
3MP0005397_hematopoietic_system_phenotyp4.12579128
4MP0002876_abnormal_thyroid_physiology3.67338272
5MP0009697_abnormal_copulation3.42688447
6MP0001835_abnormal_antigen_presentation3.33117018
7MP0010094_abnormal_chromosome_stability2.89543813
8MP0003693_abnormal_embryo_hatching2.86771839
9MP0008057_abnormal_DNA_replication2.84300877
10MP0003718_maternal_effect2.75503184
11MP0008058_abnormal_DNA_repair2.64524774
12MP0003221_abnormal_cardiomyocyte_apopto2.55953442
13MP0003724_increased_susceptibility_to2.53913339
14MP0001986_abnormal_taste_sensitivity2.44066954
15MP0003077_abnormal_cell_cycle2.41713354
16MP0005464_abnormal_platelet_physiology2.31875263
17MP0004782_abnormal_surfactant_physiolog2.31834229
18MP0003111_abnormal_nucleus_morphology2.24333290
19MP0002148_abnormal_hypersensitivity_rea2.24091077
20MP0006054_spinal_hemorrhage2.20033908
21MP0003186_abnormal_redox_activity2.19892813
22MP0003941_abnormal_skin_development2.16357132
23MP0010352_gastrointestinal_tract_polyps2.14674968
24MP0009785_altered_susceptibility_to2.13004480
25MP0001905_abnormal_dopamine_level2.10987595
26MP0003656_abnormal_erythrocyte_physiolo2.10283392
27MP0000749_muscle_degeneration2.03732618
28MP0005671_abnormal_response_to2.02417593
29MP0008932_abnormal_embryonic_tissue2.00580021
30MP0000566_synostosis1.97399722
31MP0002009_preneoplasia1.88732378
32MP0002419_abnormal_innate_immunity1.85638093
33MP0003646_muscle_fatigue1.84800068
34MP0003806_abnormal_nucleotide_metabolis1.84196531
35MP0001730_embryonic_growth_arrest1.73785521
36MP0004215_abnormal_myocardial_fiber1.73132096
37MP0005000_abnormal_immune_tolerance1.70618488
38MP0004145_abnormal_muscle_electrophysio1.69776489
39MP0006276_abnormal_autonomic_nervous1.68595941
40MP0001764_abnormal_homeostasis1.66271314
41MP0001853_heart_inflammation1.60999683
42MP0003436_decreased_susceptibility_to1.58765398
43MP0000685_abnormal_immune_system1.58308017
44MP0000681_abnormal_thyroid_gland1.58284298
45MP0010234_abnormal_vibrissa_follicle1.57211259
46MP0003890_abnormal_embryonic-extraembry1.56131536
47MP0008007_abnormal_cellular_replicative1.53643060
48MP0002163_abnormal_gland_morphology1.53142422
49MP0005310_abnormal_salivary_gland1.50147862
50MP0000350_abnormal_cell_proliferation1.49527255
51MP0005646_abnormal_pituitary_gland1.48693114
52MP0008789_abnormal_olfactory_epithelium1.46162718
53MP0003763_abnormal_thymus_physiology1.43661182
54MP0004957_abnormal_blastocyst_morpholog1.43374777
55MP0008260_abnormal_autophagy1.41505158
56MP0002796_impaired_skin_barrier1.40629334
57MP0003195_calcinosis1.39195299
58MP0006036_abnormal_mitochondrial_physio1.39043310
59MP0002452_abnormal_antigen_presenting1.38782538
60MP0004808_abnormal_hematopoietic_stem1.38472469
61MP0005025_abnormal_response_to1.37626803
62MP0002420_abnormal_adaptive_immunity1.35636843
63MP0005451_abnormal_body_composition1.35196767
64MP0003786_premature_aging1.34053991
65MP0001542_abnormal_bone_strength1.33813558
66MP0001819_abnormal_immune_cell1.32839302
67MP0002398_abnormal_bone_marrow1.32498911
68MP0005387_immune_system_phenotype1.30901840
69MP0001790_abnormal_immune_system1.30901840
70MP0001915_intracranial_hemorrhage1.28128758
71MP0002102_abnormal_ear_morphology1.28019512
72MP0009333_abnormal_splenocyte_physiolog1.27608019
73MP0002723_abnormal_immune_serum1.24909360
74MP0005084_abnormal_gallbladder_morpholo1.24812840
75MP0003943_abnormal_hepatobiliary_system1.24329389
76MP0000372_irregular_coat_pigmentation1.19688608
77MP0002006_tumorigenesis1.17426817
78MP0002166_altered_tumor_susceptibility1.17022822
79MP0001188_hyperpigmentation1.16283973
80MP0009764_decreased_sensitivity_to1.15065004
81MP0000716_abnormal_immune_system1.13646480
82MP0004233_abnormal_muscle_weight1.13419676
83MP0001800_abnormal_humoral_immune1.13247104
84MP0002139_abnormal_hepatobiliary_system1.12535824
85MP0005385_cardiovascular_system_phenoty1.11925491
86MP0009672_abnormal_birth_weight1.11515179
87MP0005266_abnormal_metabolism1.10303782
88MP0010307_abnormal_tumor_latency1.09602141
89MP0002429_abnormal_blood_cell1.08815231
90MP0000689_abnormal_spleen_morphology1.08032038
91MP0001756_abnormal_urination1.06147750
92MP0000313_abnormal_cell_death1.05941645
93MP0001672_abnormal_embryogenesis/_devel1.05668947
94MP0005380_embryogenesis_phenotype1.05668947
95MP0002332_abnormal_exercise_endurance1.04654011
96MP0004484_altered_response_of1.03771185
97MP0008877_abnormal_DNA_methylation1.03569606
98MP0004036_abnormal_muscle_relaxation1.03568065
99MP0002106_abnormal_muscle_physiology1.03235127
100MP0001697_abnormal_embryo_size1.02806832
101MP0002090_abnormal_vision1.00674209
102MP0002972_abnormal_cardiac_muscle0.98186629
103MP0008469_abnormal_protein_level0.97912395
104MP0005501_abnormal_skin_physiology0.94917990
105MP0002396_abnormal_hematopoietic_system0.94767703
106MP0004883_abnormal_blood_vessel0.94762513
107MP0006082_CNS_inflammation0.94340874
108MP0005379_endocrine/exocrine_gland_phen0.93782244
109MP0000465_gastrointestinal_hemorrhage0.93658526
110MP0001346_abnormal_lacrimal_gland0.93433120
111MP0004087_abnormal_muscle_fiber0.92673950
112MP0000747_muscle_weakness0.92595883
113MP0002269_muscular_atrophy0.92460837
114MP0002877_abnormal_melanocyte_morpholog0.91865812
115MP0005075_abnormal_melanosome_morpholog0.91398067
116MP0003984_embryonic_growth_retardation0.89636391
117MP0002722_abnormal_immune_system0.88523118
118MP0008995_early_reproductive_senescence0.88473976
119MP0002088_abnormal_embryonic_growth/wei0.88162891
120MP0001845_abnormal_inflammatory_respons0.87450537
121MP0000015_abnormal_ear_pigmentation0.86433422
122MP0001533_abnormal_skeleton_physiology0.86146306
123MP0006035_abnormal_mitochondrial_morpho0.85840208
124MP0000358_abnormal_cell_content/0.85810667
125MP0002019_abnormal_tumor_incidence0.85140409
126MP0003123_paternal_imprinting0.84810480
127MP0004147_increased_porphyrin_level0.84525773
128MP0000703_abnormal_thymus_morphology0.83608200
129MP0001177_atelectasis0.81376155
130MP0000490_abnormal_crypts_of0.81001270
131MP0002080_prenatal_lethality0.80797951
132MP0005248_abnormal_Harderian_gland0.80479220
133MP0000516_abnormal_urinary_system0.80211408
134MP0005367_renal/urinary_system_phenotyp0.80211408
135MP0004084_abnormal_cardiac_muscle0.80078662
136MP0005499_abnormal_olfactory_system0.79675565
137MP0005394_taste/olfaction_phenotype0.79675565
138MP0002736_abnormal_nociception_after0.79494701
139MP0002693_abnormal_pancreas_physiology0.77863756
140MP0003279_aneurysm0.77716883
141MP0001929_abnormal_gametogenesis0.76781870
142MP0002638_abnormal_pupillary_reflex0.76761536
143MP0010386_abnormal_urinary_bladder0.76350991
144MP0002971_abnormal_brown_adipose0.75956498
145MP0003950_abnormal_plasma_membrane0.75408110
146MP0000759_abnormal_skeletal_muscle0.73794380
147MP0002127_abnormal_cardiovascular_syste0.73731687
148MP0006292_abnormal_olfactory_placode0.73526905
149MP0009703_decreased_birth_body0.73044908
150MP0002735_abnormal_chemical_nociception0.70156747
151MP0005408_hypopigmentation0.68331903
152MP0002405_respiratory_system_inflammati0.68239798
153MP0005584_abnormal_enzyme/coenzyme_acti0.68208922
154MP0005376_homeostasis/metabolism_phenot0.67180091
155MP0004510_myositis0.66185979
156MP0000230_abnormal_systemic_arterial0.65866584
157MP0001968_abnormal_touch/_nociception0.65158501
158MP0003567_abnormal_fetal_cardiomyocyte0.64397420
159MP0002160_abnormal_reproductive_system0.63590465
160MP0005535_abnormal_body_temperature0.63537511
161MP0001348_abnormal_lacrimal_gland0.61404609
162MP0001544_abnormal_cardiovascular_syste0.57865373

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)7.84765841
2Dyskinesia (HP:0100660)7.42950809
3Acute hepatic failure (HP:0006554)6.35380171
4Self-mutilation (HP:0000742)5.34841830
5Nemaline bodies (HP:0003798)5.27799593
6Inappropriate behavior (HP:0000719)5.13664352
7Muscle fiber inclusion bodies (HP:0100299)4.98047946
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.88641228
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.82354859
10Personality changes (HP:0000751)4.64665616
11Exercise-induced muscle cramps (HP:0003710)4.43611748
12Poikilocytosis (HP:0004447)3.82803251
13Increased IgM level (HP:0003496)3.56042342
14Vasculitis (HP:0002633)3.50617251
15Eczematoid dermatitis (HP:0000976)3.37506122
16Drooling (HP:0002307)3.08966848
17Excessive salivation (HP:0003781)3.08966848
18Gonadotropin excess (HP:0000837)3.01608662
19Abnormality of T cell number (HP:0011839)3.00792343
20Choreoathetosis (HP:0001266)2.97732364
21Recurrent cutaneous fungal infections (HP:0011370)2.97047275
22Chronic mucocutaneous candidiasis (HP:0002728)2.97047275
23Papillary thyroid carcinoma (HP:0002895)2.92747665
24Abnormality of methionine metabolism (HP:0010901)2.91308300
25Hypothermia (HP:0002045)2.88496867
26IgM deficiency (HP:0002850)2.78681111
27Irregular epiphyses (HP:0010582)2.78105551
28Posterior subcapsular cataract (HP:0007787)2.77813053
29Abnormality of T cell physiology (HP:0011840)2.77429484
30Abnormality of the anterior horn cell (HP:0006802)2.75533640
31Degeneration of anterior horn cells (HP:0002398)2.75533640
32Abnormal hair whorl (HP:0010721)2.75350513
33Rimmed vacuoles (HP:0003805)2.72949281
34Homocystinuria (HP:0002156)2.70810113
35Abnormality of homocysteine metabolism (HP:0010919)2.70810113
36Thyroid carcinoma (HP:0002890)2.67974065
37Autoimmune thrombocytopenia (HP:0001973)2.61715228
38Recurrent abscess formation (HP:0002722)2.59025101
39Subaortic stenosis (HP:0001682)2.58905521
40Abnormality of the left ventricular outflow tract (HP:0011103)2.58905521
41Cutaneous melanoma (HP:0012056)2.58684591
42Insidious onset (HP:0003587)2.56013387
43Termporal pattern (HP:0011008)2.56013387
44Metaphyseal dysplasia (HP:0100255)2.50924562
45Hypoglycemic seizures (HP:0002173)2.50142835
46Anxiety (HP:0000739)2.49319271
47Exercise-induced myalgia (HP:0003738)2.48828298
48Recurrent bacterial skin infections (HP:0005406)2.48477576
49Recurrent fungal infections (HP:0002841)2.47185816
50Increased hepatocellular lipid droplets (HP:0006565)2.46823675
51Abnormality of glycolysis (HP:0004366)2.46713066
52Abnormality of the basal ganglia (HP:0002134)2.44591203
53T lymphocytopenia (HP:0005403)2.42823928
54Mediastinal lymphadenopathy (HP:0100721)2.39272573
55Increased serum pyruvate (HP:0003542)2.38811271
56Abnormal lung lobation (HP:0002101)2.36644457
57Rhabdomyolysis (HP:0003201)2.33854241
58Abnormal auditory evoked potentials (HP:0006958)2.33818121
59Nephroblastoma (Wilms tumor) (HP:0002667)2.31148405
60Methylmalonic acidemia (HP:0002912)2.30365326
61Birth length less than 3rd percentile (HP:0003561)2.28929703
62Recurrent gram-negative bacterial infections (HP:0005420)2.28707835
63Tetraparesis (HP:0002273)2.27768058
64Embryonal renal neoplasm (HP:0011794)2.27089861
65Abnormality of salivation (HP:0100755)2.26788562
66Muscle hypertrophy of the lower extremities (HP:0008968)2.25839374
67Abnormal gallbladder physiology (HP:0012438)2.25548194
68Cholecystitis (HP:0001082)2.25548194
69Recurrent skin infections (HP:0001581)2.24247710
70Osteomalacia (HP:0002749)2.23444882
71Myoglobinuria (HP:0002913)2.22851043
72Pallor (HP:0000980)2.21393078
73Shoulder girdle muscle weakness (HP:0003547)2.19103475
74EMG: myopathic abnormalities (HP:0003458)2.19014279
75Abnormality of the hip-girdle musculature (HP:0001445)2.16952557
76Abnormality of the musculature of the pelvis (HP:0001469)2.16952557
77Neutropenia (HP:0001875)2.11589810
78Abnormal gallbladder morphology (HP:0012437)2.09591243
79Neck muscle weakness (HP:0000467)2.09331578
80Recurrent viral infections (HP:0004429)2.09275719
81Agammaglobulinemia (HP:0004432)2.06960497
82Sensory axonal neuropathy (HP:0003390)2.06923157
83Amniotic constriction ring (HP:0009775)2.06870165
84Abnormality of placental membranes (HP:0011409)2.06870165
85Lipid accumulation in hepatocytes (HP:0006561)2.06443930
86Calf muscle hypertrophy (HP:0008981)2.05855761
87Abnormality of T cells (HP:0002843)2.04472471
88Beaking of vertebral bodies (HP:0004568)2.04103682
89Reduced antithrombin III activity (HP:0001976)2.03916455
90Nausea (HP:0002018)2.03663727
91IgG deficiency (HP:0004315)2.03552961
92Hypoglycemic coma (HP:0001325)2.02431803
93Exertional dyspnea (HP:0002875)2.02173634
94Microglossia (HP:0000171)2.00879963
95Acanthocytosis (HP:0001927)10.4882554
96Spinal canal stenosis (HP:0003416)1.99984469
97Psychosis (HP:0000709)1.98123847
98Aplastic anemia (HP:0001915)1.96597200
99Stomatitis (HP:0010280)1.95569320
100Carpal bone hypoplasia (HP:0001498)1.95382180
101Paralysis (HP:0003470)1.95165124
102Postnatal microcephaly (HP:0005484)1.95158730
103Pelvic girdle muscle weakness (HP:0003749)1.93009703
104Dyschromatopsia (HP:0007641)1.92408881
105Metaphyseal irregularity (HP:0003025)1.91606442
106Increased intramyocellular lipid droplets (HP:0012240)1.91527382
107Secondary amenorrhea (HP:0000869)1.91047252
108Cholelithiasis (HP:0001081)1.90524356
109Cortical dysplasia (HP:0002539)1.89519059
110Type 2 muscle fiber atrophy (HP:0003554)1.89458951
111Short tibia (HP:0005736)1.89427717
112Neoplasm of the adrenal gland (HP:0100631)1.89144290
113Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88740767
114Tongue fasciculations (HP:0001308)1.87282561
115Barrel-shaped chest (HP:0001552)1.87193072
116Symptomatic seizures (HP:0011145)1.87068148
117Short middle phalanx of the 5th finger (HP:0004220)1.83644738
118Autoamputation (HP:0001218)1.83364174
119Fatigue (HP:0012378)1.82851451
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.82526071
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82526071
122Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81375182
123Hepatosplenomegaly (HP:0001433)1.80369192
124Deep philtrum (HP:0002002)1.79698100
125Areflexia of lower limbs (HP:0002522)1.78543197
126Abnormality of the columella (HP:0009929)1.77524880
127Renal Fanconi syndrome (HP:0001994)1.77467711
128Hyperinsulinemic hypoglycemia (HP:0000825)1.77243054
129Transitional cell carcinoma of the bladder (HP:0006740)1.77057142
130Hepatic necrosis (HP:0002605)1.76314039
131Muscle stiffness (HP:0003552)1.76140593
132Abnormality of the labia minora (HP:0012880)1.76077229
133Distal arthrogryposis (HP:0005684)1.76040546
134Mucosal telangiectasiae (HP:0100579)1.75941847
135Enlarged epiphyses (HP:0010580)1.75706017
136Biliary tract neoplasm (HP:0100574)1.75129086
137Abnormality of the septum pellucidum (HP:0007375)1.75005007
138Dysautonomia (HP:0002459)1.74921295
139Palpitations (HP:0001962)1.74102216
140Alveolar cell carcinoma (HP:0006519)1.73409013
141Abnormality of incisor morphology (HP:0011063)1.73135688
142Spontaneous abortion (HP:0005268)1.72803429
143Hepatocellular necrosis (HP:0001404)1.71527372
144Ovarian neoplasm (HP:0100615)1.70910475
145Difficulty running (HP:0009046)1.70906514
146Supernumerary spleens (HP:0009799)1.70536451
147Petechiae (HP:0000967)1.69497611
148Obstructive lung disease (HP:0006536)1.68797960
149Chronic obstructive pulmonary disease (HP:0006510)1.68797960
150Median cleft lip (HP:0000161)1.68141699
151Methylmalonic aciduria (HP:0012120)1.67597405
152Abnormality of chromosome stability (HP:0003220)1.65191382
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65127848
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65127848
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.65085459
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.64220887
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.62890107
158Respiratory difficulties (HP:0002880)1.62436666
159Autoimmune hemolytic anemia (HP:0001890)1.62214871
1603-Methylglutaconic aciduria (HP:0003535)1.62154713
161Abnormality of fatty-acid metabolism (HP:0004359)1.61910185
162Meningitis (HP:0001287)1.60445747
163Volvulus (HP:0002580)1.60297307
164Menstrual irregularities (HP:0000858)1.60226346
165Proximal tubulopathy (HP:0000114)1.59986066
166Memory impairment (HP:0002354)1.59753765
167Type 1 muscle fiber predominance (HP:0003803)1.59369340
168Hypoplastic left heart (HP:0004383)1.58587633
169Conjunctival hamartoma (HP:0100780)1.58193926
170Chromsome breakage (HP:0040012)1.57397749
171Abnormality of the femoral head (HP:0003368)1.56729227
172Hypoplasia of the fovea (HP:0007750)1.55780695
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.55780695
174Elevated erythrocyte sedimentation rate (HP:0003565)1.55209201
175Hypergammaglobulinemia (HP:0010702)1.55037736
176Mitochondrial inheritance (HP:0001427)1.54351818
177Thrombocytosis (HP:0001894)1.53377089
178Pancreatic islet-cell hyperplasia (HP:0004510)1.53344871
179Microvesicular hepatic steatosis (HP:0001414)1.53131739
180Muscle fibrillation (HP:0010546)1.51394603
181Joint hemorrhage (HP:0005261)1.51093803
182Long clavicles (HP:0000890)1.50707880
183Syringomyelia (HP:0003396)1.50391890
184Spinal cord lesions (HP:0100561)1.50391890
185Chronic otitis media (HP:0000389)1.49728117
186Flared iliac wings (HP:0002869)1.49586072
187Fair hair (HP:0002286)1.48659828
188Generalized aminoaciduria (HP:0002909)1.48469913
189Joint swelling (HP:0001386)1.46697962
190Glucose intolerance (HP:0000833)1.45212574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.46376208
2BCR4.01197497
3EIF2AK13.97387108
4CASK3.27595217
5TRIM282.97961679
6MST42.97739974
7MKNK12.90749321
8OBSCN2.62169801
9BRSK22.35574959
10TXK2.33036993
11STK32.27231035
12MAP3K142.26942900
13BMPR22.26868783
14NEK12.21678016
15NEK92.20427544
16ERBB32.13378609
17ZAK2.06496366
18MKNK22.05729204
19NEK61.99319247
20PIK3CA1.90736630
21RPS6KA41.90160814
22PBK1.89986650
23MAP3K121.81888058
24FRK1.79809161
25CDK81.79331335
26TAF11.76268134
27AKT31.60759527
28NUAK11.57941463
29STK161.54698261
30MAP3K91.54246530
31ADRBK21.54162271
32TTK1.53380499
33LATS11.49891364
34BRD41.49132023
35SCYL21.48800707
36JAK31.44318029
37GRK71.37174088
38MAP4K11.34078793
39PLK41.32785023
40EIF2AK31.26655284
41DYRK31.24637107
42MYLK1.24531931
43INSRR1.19088551
44BUB11.17204905
45TSSK61.14301816
46YES11.12785569
47CDK61.10932550
48TIE11.08854570
49CDC42BPA1.08384904
50STK41.07770663
51WEE11.07463106
52PRPF4B1.07368362
53TNK21.02340464
54CDC71.00025239
55IKBKB0.97555228
56VRK10.97357817
57PLK20.93174113
58CHUK0.92931826
59TEC0.89063308
60BRSK10.88902060
61PASK0.88814554
62STK390.88804860
63STK100.88614997
64CDK30.87699365
65EIF2AK20.85234447
66GRK50.85086527
67STK240.83951246
68TGFBR20.82797624
69MUSK0.81609193
70MAP2K70.80981021
71PLK30.80865648
72NLK0.77979720
73SGK20.76435048
74KSR20.76316982
75CCNB10.76007659
76PINK10.75709492
77CDK190.72851975
78SRPK10.72559126
79IRAK20.68803814
80CLK10.67842166
81KSR10.66265362
82NME20.66246738
83RIPK40.65361739
84MAP3K50.59536813
85TBK10.58866978
86TAOK20.58763109
87SYK0.57218020
88PRKCD0.54977751
89PDK20.54685595
90MINK10.54600935
91TRPM70.53209549
92IRAK40.52746974
93CAMKK20.52741357
94PIK3CG0.52593844
95RAF10.52093028
96STK38L0.51661413
97PHKG20.51438323
98PHKG10.51438323
99MAP3K20.50830609
100MAP4K20.50762855
101MAP2K30.50404482
102PRKG20.49852852
103ZAP700.49773311
104IKBKE0.49608937
105BMPR1B0.47556374
106EGFR0.44127419
107CDK90.43899694
108BRAF0.43424194
109CDK40.43130473
110CSNK2A10.42408684
111DAPK10.41770002
112TNIK0.40813650
113BTK0.40332300
114CDK140.39962914
115CDK70.39858376
116OXSR10.39059207
117MAP3K80.38685302
118MAPKAPK20.38282880
119CHEK10.37240060
120PRKCE0.36532440
121PTK2B0.35971402
122DYRK1B0.34882667
123MAPKAPK50.34306821
124RPS6KA60.33363705
125LYN0.32575418
126ALK0.32201502
127ATM0.32129184
128ILK0.31586486
129PLK10.31586441
130JAK20.31094926
131CSNK1G30.31016458
132SGK30.29936774
133LCK0.29477524
134AURKB0.29441723
135CSNK2A20.28816514
136MOS0.28663995
137ACVR1B0.28625620
138LIMK10.28457932
139PIM20.28122907
140CSK0.27156768
141MARK30.26095707
142RPS6KC10.25988609
143RPS6KL10.25988609
144CSNK1G10.25374382
145FLT30.24844286
146LRRK20.23963550
147PRKG10.23913738
148IRAK10.23476489
149TESK10.23108014
150PIM10.22592691
151MAPK70.22394940
152CSF1R0.21978855

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.05037578
2Protein export_Homo sapiens_hsa030603.61435167
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.37139430
4Allograft rejection_Homo sapiens_hsa053303.06974375
5RNA degradation_Homo sapiens_hsa030182.75362759
6Graft-versus-host disease_Homo sapiens_hsa053322.74916382
7RNA polymerase_Homo sapiens_hsa030202.34684937
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28497439
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27705915
10Type I diabetes mellitus_Homo sapiens_hsa049402.27165985
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19238136
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10055123
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01211940
14Oocyte meiosis_Homo sapiens_hsa041141.95653031
15Legionellosis_Homo sapiens_hsa051341.90913894
16Leishmaniasis_Homo sapiens_hsa051401.88391773
17Base excision repair_Homo sapiens_hsa034101.87571260
18Rheumatoid arthritis_Homo sapiens_hsa053231.86223441
19Autoimmune thyroid disease_Homo sapiens_hsa053201.73386187
20Regulation of autophagy_Homo sapiens_hsa041401.70329671
21Pyrimidine metabolism_Homo sapiens_hsa002401.69039005
22Circadian rhythm_Homo sapiens_hsa047101.68235020
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62182155
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60912572
25Antigen processing and presentation_Homo sapiens_hsa046121.57499244
26Primary immunodeficiency_Homo sapiens_hsa053401.53533468
27mRNA surveillance pathway_Homo sapiens_hsa030151.51182053
28Purine metabolism_Homo sapiens_hsa002301.50572111
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.45669675
30Measles_Homo sapiens_hsa051621.33596053
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33270764
32Collecting duct acid secretion_Homo sapiens_hsa049661.33109935
33Pyruvate metabolism_Homo sapiens_hsa006201.32110364
34Cell cycle_Homo sapiens_hsa041101.31577502
35Phagosome_Homo sapiens_hsa041451.26751172
36Carbon metabolism_Homo sapiens_hsa012001.24178392
37Nucleotide excision repair_Homo sapiens_hsa034201.23941657
38Non-homologous end-joining_Homo sapiens_hsa034501.21491016
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21065226
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.17815611
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15946055
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15194568
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.14190344
44Spliceosome_Homo sapiens_hsa030401.13943788
45Pentose phosphate pathway_Homo sapiens_hsa000301.13843678
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12772468
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10962940
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08757834
49African trypanosomiasis_Homo sapiens_hsa051431.08582309
50Thyroid cancer_Homo sapiens_hsa052161.08193143
51DNA replication_Homo sapiens_hsa030301.08172024
52Ribosome_Homo sapiens_hsa030101.04437221
53Peroxisome_Homo sapiens_hsa041461.04368466
54p53 signaling pathway_Homo sapiens_hsa041151.02958336
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02858635
56Basal transcription factors_Homo sapiens_hsa030220.98041861
57Epstein-Barr virus infection_Homo sapiens_hsa051690.97079515
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96677378
59Propanoate metabolism_Homo sapiens_hsa006400.94937062
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94001329
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92395591
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91961124
63Hematopoietic cell lineage_Homo sapiens_hsa046400.91144438
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90517925
65Asthma_Homo sapiens_hsa053100.88674315
66Oxidative phosphorylation_Homo sapiens_hsa001900.87064482
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86958191
68RNA transport_Homo sapiens_hsa030130.86908522
69Sulfur metabolism_Homo sapiens_hsa009200.86167041
70Influenza A_Homo sapiens_hsa051640.84938984
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84484729
72Phenylalanine metabolism_Homo sapiens_hsa003600.82138107
73Fanconi anemia pathway_Homo sapiens_hsa034600.80169148
74Folate biosynthesis_Homo sapiens_hsa007900.79633373
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79549569
76Malaria_Homo sapiens_hsa051440.76244129
77B cell receptor signaling pathway_Homo sapiens_hsa046620.75734308
78Fatty acid elongation_Homo sapiens_hsa000620.75458275
79Hepatitis B_Homo sapiens_hsa051610.75033123
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.74407514
81Pertussis_Homo sapiens_hsa051330.73330807
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72907601
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71757819
84Fatty acid metabolism_Homo sapiens_hsa012120.71131654
85Herpes simplex infection_Homo sapiens_hsa051680.71128445
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.70870601
87Viral myocarditis_Homo sapiens_hsa054160.69962110
88Chemokine signaling pathway_Homo sapiens_hsa040620.69386068
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.69071255
90Tuberculosis_Homo sapiens_hsa051520.68422647
91Parkinsons disease_Homo sapiens_hsa050120.68239904
92Viral carcinogenesis_Homo sapiens_hsa052030.66489952
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66086310
94T cell receptor signaling pathway_Homo sapiens_hsa046600.65251935
95Arachidonic acid metabolism_Homo sapiens_hsa005900.64931094
96Vibrio cholerae infection_Homo sapiens_hsa051100.63012435
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60808682
98Alzheimers disease_Homo sapiens_hsa050100.60493514
99Staphylococcus aureus infection_Homo sapiens_hsa051500.58632849
100Glutathione metabolism_Homo sapiens_hsa004800.53504704
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52243951
102Arginine and proline metabolism_Homo sapiens_hsa003300.52155813
103One carbon pool by folate_Homo sapiens_hsa006700.51458050
104Vitamin B6 metabolism_Homo sapiens_hsa007500.50242388
105Biosynthesis of amino acids_Homo sapiens_hsa012300.49562774
106Steroid biosynthesis_Homo sapiens_hsa001000.48075078
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47626235
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46855485
109Non-small cell lung cancer_Homo sapiens_hsa052230.44884934
110Sphingolipid metabolism_Homo sapiens_hsa006000.44112118
111Adherens junction_Homo sapiens_hsa045200.42181455
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41994370
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41931664
114Toxoplasmosis_Homo sapiens_hsa051450.40066584
115Dorso-ventral axis formation_Homo sapiens_hsa043200.38132212
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38096755
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.37923353
118Mismatch repair_Homo sapiens_hsa034300.37779489
119Endometrial cancer_Homo sapiens_hsa052130.37376481
120Lysosome_Homo sapiens_hsa041420.36785373
121Fructose and mannose metabolism_Homo sapiens_hsa000510.36679271
122Salmonella infection_Homo sapiens_hsa051320.36467102
123Selenocompound metabolism_Homo sapiens_hsa004500.35898856
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35067448
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.34869718
126Histidine metabolism_Homo sapiens_hsa003400.34540065
127Endocytosis_Homo sapiens_hsa041440.34143414
128Prostate cancer_Homo sapiens_hsa052150.34099982
129Homologous recombination_Homo sapiens_hsa034400.33979215
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33886054
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33472695
132HTLV-I infection_Homo sapiens_hsa051660.33430441
133Galactose metabolism_Homo sapiens_hsa000520.31765995
134Huntingtons disease_Homo sapiens_hsa050160.30136609
135Renal cell carcinoma_Homo sapiens_hsa052110.29958793
136Colorectal cancer_Homo sapiens_hsa052100.29827385
137Osteoclast differentiation_Homo sapiens_hsa043800.29407579
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29281773
139Shigellosis_Homo sapiens_hsa051310.28270982
140Fatty acid biosynthesis_Homo sapiens_hsa000610.28096463
141FoxO signaling pathway_Homo sapiens_hsa040680.27914644
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26423871

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