PPP6R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46126398
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46126398
3positive regulation of gamma-delta T cell activation (GO:0046645)5.04496532
4regulation of gamma-delta T cell differentiation (GO:0045586)4.95323063
5positive regulation of histone deacetylation (GO:0031065)4.87881405
6antigen processing and presentation of endogenous antigen (GO:0019883)4.86643903
7regulation of gamma-delta T cell activation (GO:0046643)4.35700150
8negative regulation of cell killing (GO:0031342)4.27607155
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.27607155
10positive thymic T cell selection (GO:0045059)4.15546238
11natural killer cell differentiation (GO:0001779)3.62339105
12thymic T cell selection (GO:0045061)3.60355051
13response to peptidoglycan (GO:0032494)3.57125251
14negative T cell selection (GO:0043383)3.54107747
15positive regulation by symbiont of host defense response (GO:0052509)3.52879240
16modulation by symbiont of host defense response (GO:0052031)3.52879240
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.52879240
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.52879240
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.52879240
20modulation by symbiont of host immune response (GO:0052553)3.52879240
21negative thymic T cell selection (GO:0045060)3.48427944
22positive T cell selection (GO:0043368)3.45313926
23positive regulation of protein deacetylation (GO:0090312)3.39472333
24response to muramyl dipeptide (GO:0032495)3.36740189
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33890604
26T cell selection (GO:0045058)3.32229858
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31911352
28negative regulation of cell size (GO:0045792)3.26510912
29leukocyte aggregation (GO:0070486)3.23915666
30germinal center formation (GO:0002467)3.22392630
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.21398646
32modulation by virus of host process (GO:0019054)3.19815808
33negative regulation of erythrocyte differentiation (GO:0045647)3.19630155
34positive regulation of B cell differentiation (GO:0045579)3.18483885
35modulation by symbiont of host cellular process (GO:0044068)3.13718369
36NIK/NF-kappaB signaling (GO:0038061)3.11421128
37protein localization to endosome (GO:0036010)3.07527852
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07359943
39regulation of cholesterol homeostasis (GO:2000188)3.03532313
40regulation of histone H3-K27 methylation (GO:0061085)3.02244940
41peptidyl-lysine dimethylation (GO:0018027)3.01758469
42regulation of leukocyte degranulation (GO:0043300)2.98812408
43detection of bacterium (GO:0016045)2.97734336
44B cell receptor signaling pathway (GO:0050853)2.95177665
45pinocytosis (GO:0006907)2.92294824
46regulation of interleukin-12 biosynthetic process (GO:0045075)2.91634577
47detection of other organism (GO:0098543)2.90416795
48regulation of fatty acid beta-oxidation (GO:0031998)2.89885798
49tolerance induction (GO:0002507)2.89483458
50neutrophil activation involved in immune response (GO:0002283)2.88453249
51response to interleukin-15 (GO:0070672)2.87432712
52positive regulation of Rap GTPase activity (GO:0032854)2.85915578
53apoptotic process involved in morphogenesis (GO:0060561)2.83720495
54antigen processing and presentation via MHC class Ib (GO:0002475)2.83272753
55regulation of ARF GTPase activity (GO:0032312)2.82676625
56activation of Rac GTPase activity (GO:0032863)2.80169092
57regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79169601
58macrophage activation involved in immune response (GO:0002281)2.78647567
59maternal placenta development (GO:0001893)2.75618311
60cytoplasmic mRNA processing body assembly (GO:0033962)2.74983992
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.74714177
62response to laminar fluid shear stress (GO:0034616)2.74449599
63regulation of translational termination (GO:0006449)2.74112053
64regulation of defense response to virus by virus (GO:0050690)2.72760604
65Peyers patch development (GO:0048541)2.71138369
66mucosal-associated lymphoid tissue development (GO:0048537)2.71138369
67dicarboxylic acid biosynthetic process (GO:0043650)2.67312791
68regulation of mast cell degranulation (GO:0043304)2.66984124
69regulation of B cell receptor signaling pathway (GO:0050855)2.66101606
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65704652
71growth hormone receptor signaling pathway (GO:0060396)2.63796148
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.63633681
73regulation of ARF protein signal transduction (GO:0032012)2.62421628
74regulation of NFAT protein import into nucleus (GO:0051532)2.62053991
75regulation of translational fidelity (GO:0006450)2.61842706
76regulation of superoxide anion generation (GO:0032928)2.61802116
77regulation of B cell differentiation (GO:0045577)2.61261274
78negative regulation of phagocytosis (GO:0050765)2.58950041
79cortical actin cytoskeleton organization (GO:0030866)2.58736967
80embryonic process involved in female pregnancy (GO:0060136)2.58639879
81intracellular estrogen receptor signaling pathway (GO:0030520)2.56913183
82cellular extravasation (GO:0045123)2.56005315
83mannose metabolic process (GO:0006013)2.55904666
84pre-miRNA processing (GO:0031054)2.55723293
85histone H3-K36 demethylation (GO:0070544)2.55533010
86sodium ion export (GO:0071436)2.54491786
87activation of JUN kinase activity (GO:0007257)2.54381790
88regulation of early endosome to late endosome transport (GO:2000641)2.54042810
89immunoglobulin mediated immune response (GO:0016064)2.53360779
90regulation of necroptotic process (GO:0060544)2.53123232
91pentose-phosphate shunt (GO:0006098)2.52918164
92alpha-linolenic acid metabolic process (GO:0036109)2.51357847
93receptor catabolic process (GO:0032801)2.51092916
94regulation of cholesterol storage (GO:0010885)2.50729957
95mRNA stabilization (GO:0048255)2.50607189
96RNA stabilization (GO:0043489)2.50607189
97regulation of interferon-beta biosynthetic process (GO:0045357)2.50148857
98cellular response to interleukin-4 (GO:0071353)2.49669563
99cellular response to virus (GO:0098586)2.49433337
100negative regulation of toll-like receptor signaling pathway (GO:0034122)2.49181872
101T cell costimulation (GO:0031295)2.49085104
102glucocorticoid receptor signaling pathway (GO:0042921)2.48981670
103negative regulation of leukocyte mediated immunity (GO:0002704)2.48524996
104positive regulation of lamellipodium assembly (GO:0010592)2.46909481
105response to host (GO:0075136)2.45731579
106response to host defenses (GO:0052200)2.45731579
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45731579
108negative regulation of viral release from host cell (GO:1902187)2.45276035
109positive regulation of granulocyte differentiation (GO:0030854)2.44903177
110germ cell migration (GO:0008354)2.44452425
111B cell homeostasis (GO:0001782)2.43444096
112negative regulation of necroptotic process (GO:0060546)2.42122227
113cellular hyperosmotic response (GO:0071474)2.41984131
114Golgi transport vesicle coating (GO:0048200)2.41954749
115COPI coating of Golgi vesicle (GO:0048205)2.41954749
116NLS-bearing protein import into nucleus (GO:0006607)2.41257181
117regulation of histone deacetylation (GO:0031063)2.41155753
118lymphocyte costimulation (GO:0031294)2.40663139
119regulation of regulated secretory pathway (GO:1903305)2.40031432
120regulation of mammary gland epithelial cell proliferation (GO:0033599)2.37696594
121negative regulation of histone methylation (GO:0031061)2.37049262
122response to type I interferon (GO:0034340)2.36616631
123regulation of T-helper 2 cell differentiation (GO:0045628)2.35808193
124negative regulation of lymphocyte mediated immunity (GO:0002707)2.35651335
125cellular response to type I interferon (GO:0071357)2.35362095
126type I interferon signaling pathway (GO:0060337)2.35362095
127activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35298350
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35147853
129response to host immune response (GO:0052572)2.35147853
130negative regulation of lipid transport (GO:0032369)2.31986552
131positive regulation of nuclease activity (GO:0032075)2.31796420
132valine metabolic process (GO:0006573)2.30826784
133T cell receptor signaling pathway (GO:0050852)2.28945400
134adaptation of signaling pathway (GO:0023058)2.27756888
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27007015
136regulation of Rap GTPase activity (GO:0032317)2.26562810
137L-alpha-amino acid transmembrane transport (GO:1902475)2.24687212
138antigen receptor-mediated signaling pathway (GO:0050851)2.23324626
139megakaryocyte development (GO:0035855)2.23216856
140epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23003090
141regulation of erythrocyte differentiation (GO:0045646)2.22233933
1422-oxoglutarate metabolic process (GO:0006103)2.22095602
143positive regulation of lamellipodium organization (GO:1902745)2.21325892
144cellular response to growth hormone stimulus (GO:0071378)2.21135541
145dosage compensation (GO:0007549)2.21082229
146T cell migration (GO:0072678)2.20516160
147adherens junction assembly (GO:0034333)2.19802514
148oxaloacetate metabolic process (GO:0006107)2.19623029
149stress fiber assembly (GO:0043149)2.19129984
150peptidyl-threonine modification (GO:0018210)2.18746402
151signal complex assembly (GO:0007172)2.18550182
152cell-substrate adherens junction assembly (GO:0007045)2.18384250
153focal adhesion assembly (GO:0048041)2.18384250
154heterochromatin organization (GO:0070828)2.18086289
155regulation of extracellular matrix disassembly (GO:0010715)2.17930631
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16825441
157negative regulation of sterol transport (GO:0032372)2.16008240
158negative regulation of cholesterol transport (GO:0032375)2.16008240
159positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.15249665
1603-UTR-mediated mRNA stabilization (GO:0070935)2.15051790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.03807921
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.75925253
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.49812747
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26098339
5VDR_21846776_ChIP-Seq_THP-1_Human3.01441924
6TCF7_22412390_ChIP-Seq_EML_Mouse2.86967896
7E2F7_22180533_ChIP-Seq_HELA_Human2.82877976
8KDM2B_26808549_Chip-Seq_DND41_Human2.71667686
9KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.57833461
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55852162
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.46470190
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.43186312
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.36270120
14MAF_26560356_Chip-Seq_TH1_Human2.33283099
15UTX_26944678_Chip-Seq_JUKART_Human2.24019561
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12078268
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.11671491
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06356295
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.03002517
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01165840
21SCL_19346495_ChIP-Seq_HPC-7_Human2.00791797
22LXR_22292898_ChIP-Seq_THP-1_Human2.00144864
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99583849
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98546056
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.97195266
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90423065
27VDR_24763502_ChIP-Seq_THP-1_Human1.89457905
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84713610
29RUNX_20019798_ChIP-Seq_JUKART_Human1.82061782
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.81374332
31MYB_26560356_Chip-Seq_TH2_Human1.80897635
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79092663
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.79053901
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72302396
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72112491
36MYB_26560356_Chip-Seq_TH1_Human1.71776101
37SPI1_23127762_ChIP-Seq_K562_Human1.70782798
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67835690
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66075763
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.63201963
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62001257
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.57912676
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56178154
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.55370352
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53272786
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51061462
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50498398
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.50144244
49RACK7_27058665_Chip-Seq_MCF-7_Human1.49379151
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48123935
51MAF_26560356_Chip-Seq_TH2_Human1.48051990
52KDM2B_26808549_Chip-Seq_K562_Human1.47316773
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45673317
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43694470
55GATA1_19941826_ChIP-Seq_K562_Human1.41239503
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40953969
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40657814
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40091547
59NCOR1_26117541_ChIP-Seq_K562_Human1.39321260
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.38697417
61SPI1_23547873_ChIP-Seq_NB4_Human1.37995446
62CLOCK_20551151_ChIP-Seq_293T_Human1.32925288
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.31829247
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31753697
65ZNF263_19887448_ChIP-Seq_K562_Human1.29726807
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28574200
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.28356113
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.27451575
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26345265
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26141131
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25176834
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24888424
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24536748
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24249550
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21539437
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21218147
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21052517
78SMC4_20622854_ChIP-Seq_HELA_Human1.19789137
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18192805
80GATA3_27048872_Chip-Seq_THYMUS_Human1.16848132
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16297724
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16281899
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16189669
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15869677
85GATA1_22025678_ChIP-Seq_K562_Human1.15651887
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15379435
87CREB1_26743006_Chip-Seq_LNCaP_Human1.15330174
88* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15120817
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14362392
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14170047
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10452703
92P68_20966046_ChIP-Seq_HELA_Human1.10447169
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10443902
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10361112
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09233200
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09094824
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08050116
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07616409
99GATA2_19941826_ChIP-Seq_K562_Human1.06681334
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06528790
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06461722
102* CIITA_25753668_ChIP-Seq_RAJI_Human1.06393316
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06356293
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06170267
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.06088652
106BCL6_27268052_Chip-Seq_Bcells_Human1.06018945
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.05919844
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05381667
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.05309460
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05095826
111ATF3_27146783_Chip-Seq_COLON_Human1.05070278
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04912917
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04767983
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.04052269
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03291008
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02650706
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02261608
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01321447
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00946578
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00615399
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99957926
122BCOR_27268052_Chip-Seq_Bcells_Human0.98499462
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97491008
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97331454
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97260264
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97014650
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96406972
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96221240
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94495338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.84907344
2MP0003303_peritoneal_inflammation3.46384983
3MP0003705_abnormal_hypodermis_morpholog3.06158972
4MP0005451_abnormal_body_composition2.83938460
5MP0009278_abnormal_bone_marrow2.62927398
6MP0008961_abnormal_basal_metabolism2.45088503
7MP0000685_abnormal_immune_system2.43852952
8MP0010352_gastrointestinal_tract_polyps2.43629991
9MP0005360_urolithiasis2.29801801
10MP0005076_abnormal_cell_differentiation2.28646325
11MP0008260_abnormal_autophagy2.13403324
12MP0009840_abnormal_foam_cell2.13102826
13MP0004510_myositis2.04632842
14MP0001800_abnormal_humoral_immune2.02700561
15MP0003763_abnormal_thymus_physiology2.02431422
16MP0003191_abnormal_cellular_cholesterol2.02313431
17MP0010234_abnormal_vibrissa_follicle1.97703389
18MP0001790_abnormal_immune_system1.93956553
19MP0005387_immune_system_phenotype1.93956553
20MP0005464_abnormal_platelet_physiology1.88599052
21MP0001835_abnormal_antigen_presentation1.85990363
22MP0002396_abnormal_hematopoietic_system1.84353238
23MP0003436_decreased_susceptibility_to1.84351031
24MP0004947_skin_inflammation1.82886156
25MP0004808_abnormal_hematopoietic_stem1.81304559
26MP0002398_abnormal_bone_marrow1.80808892
27MP0002166_altered_tumor_susceptibility1.79145003
28MP0002139_abnormal_hepatobiliary_system1.78267344
29MP0010307_abnormal_tumor_latency1.68660339
30MP0005397_hematopoietic_system_phenotyp1.67494023
31MP0001545_abnormal_hematopoietic_system1.67494023
32MP0000858_altered_metastatic_potential1.66728892
33MP0000703_abnormal_thymus_morphology1.60235842
34MP0002452_abnormal_antigen_presenting1.59488696
35MP0003566_abnormal_cell_adhesion1.57781502
36MP0010155_abnormal_intestine_physiology1.55476017
37MP0002420_abnormal_adaptive_immunity1.53402329
38MP0004185_abnormal_adipocyte_glucose1.52585313
39MP0001819_abnormal_immune_cell1.51767203
40MP0002722_abnormal_immune_system1.51625119
41MP0003252_abnormal_bile_duct1.51443412
42MP0002723_abnormal_immune_serum1.51045404
43MP0000689_abnormal_spleen_morphology1.49253190
44MP0003866_abnormal_defecation1.48985302
45MP0000716_abnormal_immune_system1.48356670
46MP0003172_abnormal_lysosome_physiology1.44929893
47MP0005000_abnormal_immune_tolerance1.42674178
48MP0001873_stomach_inflammation1.41062691
49MP0005671_abnormal_response_to1.36657649
50MP0004130_abnormal_muscle_cell1.36370571
51MP0000609_abnormal_liver_physiology1.36052564
52MP0005365_abnormal_bile_salt1.35077272
53MP0004381_abnormal_hair_follicle1.34950422
54MP0002877_abnormal_melanocyte_morpholog1.33509370
55MP0002405_respiratory_system_inflammati1.28174673
56MP0005025_abnormal_response_to1.28166436
57MP0010329_abnormal_lipoprotein_level1.28068971
58MP0002429_abnormal_blood_cell1.27340509
59MP0002148_abnormal_hypersensitivity_rea1.26377253
60MP0005085_abnormal_gallbladder_physiolo1.26349536
61MP0003045_fibrosis1.26080398
62MP0005409_darkened_coat_color1.21232332
63MP0003724_increased_susceptibility_to1.20947077
64MP0006082_CNS_inflammation1.20724522
65MP0002998_abnormal_bone_remodeling1.17869435
66MP0005058_abnormal_lysosome_morphology1.16756041
67MP0002419_abnormal_innate_immunity1.16466971
68MP0000678_abnormal_parathyroid_gland1.16118432
69MP0001845_abnormal_inflammatory_respons1.15019662
70MP0002006_tumorigenesis1.13911456
71MP0005666_abnormal_adipose_tissue1.09526605
72MP0001348_abnormal_lacrimal_gland1.09085973
73MP0000604_amyloidosis1.05878701
74MP0000569_abnormal_digit_pigmentation1.05721662
75MP0003075_altered_response_to1.04747695
76MP0001851_eye_inflammation1.04078254
77MP0005083_abnormal_biliary_tract1.03930856
78MP0001849_ear_inflammation1.03100734
79MP0000465_gastrointestinal_hemorrhage1.01876910
80MP0004264_abnormal_extraembryonic_tissu1.01688102
81MP0009333_abnormal_splenocyte_physiolog0.97843370
82MP0005621_abnormal_cell_physiology0.97733764
83MP0003828_pulmonary_edema0.96883769
84MP0005375_adipose_tissue_phenotype0.95201757
85MP0002796_impaired_skin_barrier0.95025543
86MP0005310_abnormal_salivary_gland0.94429166
87MP0002132_abnormal_respiratory_system0.93496522
88MP0003111_abnormal_nucleus_morphology0.93171507
89MP0005023_abnormal_wound_healing0.92924830
90MP0010630_abnormal_cardiac_muscle0.91058765
91MP0003183_abnormal_peptide_metabolism0.90211620
92MP0003329_amyloid_beta_deposits0.89783308
93MP0000598_abnormal_liver_morphology0.89105532
94MP0003091_abnormal_cell_migration0.89041549
95MP0005166_decreased_susceptibility_to0.87331913
96MP0004858_abnormal_nervous_system0.85791872
97MP0002138_abnormal_hepatobiliary_system0.82986782
98MP0008469_abnormal_protein_level0.82826767
99MP0009785_altered_susceptibility_to0.82666895
100MP0002909_abnormal_adrenal_gland0.81428036
101MP0008874_decreased_physiological_sensi0.81398861
102MP0005501_abnormal_skin_physiology0.80736207
103MP0002019_abnormal_tumor_incidence0.80468868
104MP0000733_abnormal_muscle_development0.80109442
105MP0001730_embryonic_growth_arrest0.79503932
106MP0009931_abnormal_skin_appearance0.79028744
107MP0003453_abnormal_keratinocyte_physiol0.78031397
108MP0003656_abnormal_erythrocyte_physiolo0.77636348
109MP0002928_abnormal_bile_duct0.77014407
110MP0001853_heart_inflammation0.76826842
111MP0000313_abnormal_cell_death0.76412149
112MP0004087_abnormal_muscle_fiber0.76046386
113MP0001915_intracranial_hemorrhage0.75841708
114MP0001666_abnormal_nutrient_absorption0.75708935
115MP0001533_abnormal_skeleton_physiology0.75623576
116MP0002086_abnormal_extraembryonic_tissu0.74851216
117MP0000350_abnormal_cell_proliferation0.74430864
118MP0003448_altered_tumor_morphology0.72778521
119MP0002970_abnormal_white_adipose0.72417192
120MP0002118_abnormal_lipid_homeostasis0.72272056
121MP0000490_abnormal_crypts_of0.72189025
122MP0005319_abnormal_enzyme/_coenzyme0.71880497
123MP0008770_decreased_survivor_rate0.71838889
124MP0002089_abnormal_postnatal_growth/wei0.71713700
125MP0000003_abnormal_adipose_tissue0.70902593
126MP0002009_preneoplasia0.70878931
127MP0002933_joint_inflammation0.69477881
128MP0001663_abnormal_digestive_system0.64167503

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.29400207
2Recurrent abscess formation (HP:0002722)3.15919897
3Papilloma (HP:0012740)3.12239601
4Verrucae (HP:0200043)3.12239601
5Recurrent viral infections (HP:0004429)3.08756151
6Cerebral aneurysm (HP:0004944)3.04480458
7Recurrent bacterial skin infections (HP:0005406)3.02938429
8Cellulitis (HP:0100658)3.01988715
9Abnormality of macrophages (HP:0004311)2.91731530
10Abnormality of the fingertips (HP:0001211)2.91442303
11Nasal polyposis (HP:0100582)2.90098567
12Colitis (HP:0002583)2.87602508
13Gastrointestinal inflammation (HP:0004386)2.76881939
14T lymphocytopenia (HP:0005403)2.76291168
15Chronic otitis media (HP:0000389)2.72008610
16Broad face (HP:0000283)2.70574191
17Obstructive lung disease (HP:0006536)2.68612957
18Chronic obstructive pulmonary disease (HP:0006510)2.68612957
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.67456516
20Abnormality of the nasal mucosa (HP:0000433)2.66938521
21Recurrent fungal infections (HP:0002841)2.66294000
22Inflammation of the large intestine (HP:0002037)2.63653199
23Deep venous thrombosis (HP:0002625)2.61602522
24Macroorchidism (HP:0000053)2.56934505
25Abnormality of T cell number (HP:0011839)2.56683358
26Gastrointestinal stroma tumor (HP:0100723)2.49876634
27Autoimmune thrombocytopenia (HP:0001973)2.43393710
28Recurrent bronchitis (HP:0002837)2.41095828
29Increased density of long bones (HP:0006392)2.40205557
30Mediastinal lymphadenopathy (HP:0100721)2.39762829
31Panhypogammaglobulinemia (HP:0003139)2.37574303
32Obstructive sleep apnea (HP:0002870)2.36629278
33Eczematoid dermatitis (HP:0000976)2.36569121
34Distal lower limb amyotrophy (HP:0008944)2.35648316
35Dysmetric saccades (HP:0000641)2.35150232
36Spontaneous hematomas (HP:0007420)2.30574083
37Hemorrhage of the eye (HP:0011885)2.28586968
38Myositis (HP:0100614)2.26360041
39Gingivitis (HP:0000230)2.24169404
40Gastrointestinal infarctions (HP:0005244)2.18999839
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.18386046
42Upper limb amyotrophy (HP:0009129)2.18041270
43Distal upper limb amyotrophy (HP:0007149)2.18041270
44Increased IgE level (HP:0003212)2.17476287
45Abnormal platelet volume (HP:0011876)2.16989294
46Recurrent skin infections (HP:0001581)2.16019123
47Hematochezia (HP:0002573)2.15377810
48Abnormality of the lower motor neuron (HP:0002366)2.15274794
49Abnormality of T cells (HP:0002843)2.13014958
50Slow saccadic eye movements (HP:0000514)2.11541610
51Hand muscle atrophy (HP:0009130)2.09348229
52Myocardial infarction (HP:0001658)2.08270573
53Polygenic inheritance (HP:0010982)2.07895722
54Increased connective tissue (HP:0009025)2.06500511
55Interstitial pulmonary disease (HP:0006530)2.06044750
56Agammaglobulinemia (HP:0004432)2.05240799
57Elfin facies (HP:0004428)2.05240241
58Increased cerebral lipofuscin (HP:0011813)2.04360869
59Frequent falls (HP:0002359)2.03915323
60Flat acetabular roof (HP:0003180)2.03759233
61Osteomyelitis (HP:0002754)2.03376997
62Insomnia (HP:0100785)2.02648650
63Abnormal platelet function (HP:0011869)2.02470767
64Impaired platelet aggregation (HP:0003540)2.02470767
65Elevated erythrocyte sedimentation rate (HP:0003565)2.01369505
66Aneurysm (HP:0002617)2.00912725
67Thoracic kyphosis (HP:0002942)2.00765833
68Ulnar bowing (HP:0003031)2.00359915
69Purpura (HP:0000979)1.99814944
70IgM deficiency (HP:0002850)1.98652618
71Emphysema (HP:0002097)1.98505608
72Vasculitis (HP:0002633)1.97911373
73Subacute progressive viral hepatitis (HP:0006572)1.95585654
74Dysostosis multiplex (HP:0000943)1.93979504
75Increased mean platelet volume (HP:0011877)1.93312285
76Pustule (HP:0200039)1.92413142
77Abnormality of the Achilles tendon (HP:0005109)1.91758057
78Hypertensive crisis (HP:0100735)1.91004340
79Polycythemia (HP:0001901)1.90844181
80Long palpebral fissure (HP:0000637)1.90843103
81Pseudobulbar signs (HP:0002200)1.90471151
82Easy fatigability (HP:0003388)1.89535290
83Chest pain (HP:0100749)1.89330800
84Increased serum ferritin (HP:0003281)1.87597686
85Urticaria (HP:0001025)1.87437705
86Heterotopia (HP:0002282)1.87024306
87Thyroiditis (HP:0100646)1.86579059
88Mitral valve prolapse (HP:0001634)1.86487725
89Petechiae (HP:0000967)1.86470363
90Papilledema (HP:0001085)1.85690385
91Aortic aneurysm (HP:0004942)1.85223943
92Vertebral arch anomaly (HP:0008438)1.84882172
93Vertebral compression fractures (HP:0002953)1.84573950
94Achilles tendon contracture (HP:0001771)1.84097955
95Reticulocytosis (HP:0001923)1.83424707
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.82304607
97Distal lower limb muscle weakness (HP:0009053)1.81719966
98Increased CSF protein (HP:0002922)1.81152750
99Renovascular hypertension (HP:0100817)1.80404728
100Resting tremor (HP:0002322)1.80086007
101Disproportionate tall stature (HP:0001519)1.79733697
102Abnormality of oral frenula (HP:0000190)1.79645075
103Enlarged penis (HP:0000040)1.78961131
104Lymphangioma (HP:0100764)1.78869596
105Deep palmar crease (HP:0006191)1.78831184
106Meningitis (HP:0001287)1.78788061
107B lymphocytopenia (HP:0010976)1.78740183
108Abnormality of B cell number (HP:0010975)1.78740183
109Mitral stenosis (HP:0001718)1.78608977
110Orchitis (HP:0100796)1.78459004
111Fatigue (HP:0012378)1.78321386
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.77484331
113Complement deficiency (HP:0004431)1.77074232
114Cholecystitis (HP:0001082)1.76219019
115Abnormal gallbladder physiology (HP:0012438)1.76219019
116Lymphopenia (HP:0001888)1.75953106
117Arterial thrombosis (HP:0004420)1.74420990
118Metaphyseal cupping (HP:0003021)1.73944483
119Segmental peripheral demyelination/remyelination (HP:0003481)1.73472854
120Pointed chin (HP:0000307)1.72839100
121Hypertriglyceridemia (HP:0002155)1.71922760
122Granulocytopenia (HP:0001913)1.70365196
123Prolonged bleeding time (HP:0003010)1.69578478
124Chronic mucocutaneous candidiasis (HP:0002728)1.69509098
125Recurrent cutaneous fungal infections (HP:0011370)1.69509098
126Loss of speech (HP:0002371)1.69317336
127Gingival bleeding (HP:0000225)1.68662698
128Spastic diplegia (HP:0001264)1.68369497
129Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68319839
130Encephalitis (HP:0002383)1.67228380
131Asymmetric septal hypertrophy (HP:0001670)1.66285193
132Skin ulcer (HP:0200042)1.65294782
133Xanthomatosis (HP:0000991)1.64744144
134Annular pancreas (HP:0001734)1.64407534
135Seborrheic dermatitis (HP:0001051)1.64295969
136Abnormality of T cell physiology (HP:0011840)1.64080864
137Basal cell carcinoma (HP:0002671)1.63967467
138Ankyloglossia (HP:0010296)1.63303560
139High pitched voice (HP:0001620)1.63003248
140Cutaneous melanoma (HP:0012056)1.62680592
141Viral hepatitis (HP:0006562)1.62562427
142Global brain atrophy (HP:0002283)1.61868265
143Recurrent gram-negative bacterial infections (HP:0005420)1.61770520
144Striae distensae (HP:0001065)1.60974834
145Combined immunodeficiency (HP:0005387)1.60203832
146Thin bony cortex (HP:0002753)1.59460047
147Hemiplegia (HP:0002301)1.58814102
148Thrombocytosis (HP:0001894)1.58501394
149Dilatation of the ascending aorta (HP:0005111)1.57392157
150Abnormality of the thoracic spine (HP:0100711)1.57040446
151Bicuspid aortic valve (HP:0001647)1.56502310
152Epistaxis (HP:0000421)1.55400560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.45027307
2EEF2K4.40563414
3PRPF4B4.01195453
4MAP3K103.95873403
5PKN23.90538746
6SMG13.34233777
7MAP4K13.25402325
8ERN12.34854455
9IRAK32.33777049
10CDK122.28575740
11GRK62.05601728
12PTK61.96997979
13FGFR41.76764422
14RIPK11.75845720
15SIK21.74893508
16STK101.71945641
17TTN1.58152886
18IRAK41.54580965
19TYK21.54454415
20ALK1.53578853
21EPHB11.51397405
22LRRK21.48669150
23MAP3K141.44689280
24TAOK21.44643923
25ICK1.40728005
26SIK11.40604044
27JAK31.35107749
28MAP3K111.34582992
29NME21.31399942
30JAK11.29948080
31ZAP701.28698106
32FGFR31.27617844
33TESK21.23886253
34MAP3K71.22556346
35MAP3K31.22242457
36SCYL21.21897061
37TAOK11.19313211
38PRKCH1.17103470
39ITK1.08077551
40CAMK1G1.06753050
41PDGFRA1.06123156
42HCK1.04300139
43JAK21.03141865
44KSR21.01778884
45BMX1.01405650
46CAMK1D0.99952334
47SIK30.99616320
48RET0.99535228
49TYRO30.97915471
50BTK0.97910529
51TAOK30.96517525
52CSK0.94894963
53SYK0.94086748
54FES0.93786346
55CSF1R0.92957094
56CDC42BPA0.92636782
57CDK40.92197474
58NEK20.90593788
59CDK60.88395775
60TBK10.86792823
61MAP2K30.86122696
62PRKD30.85663202
63DMPK0.85622336
64CAMKK10.85600855
65MTOR0.85271992
66IRAK20.84772452
67FLT30.82314355
68PDK10.81795931
69EPHA20.77879240
70MAPK110.77300823
71SGK30.74962717
72PDGFRB0.74071957
73TGFBR20.72350650
74RIPK40.72009661
75MAP3K130.70453243
76HIPK20.69840773
77RPS6KB20.67154340
78ARAF0.66023979
79LCK0.64916383
80MAP3K80.64112264
81MAP2K20.62583882
82MST1R0.62009324
83CLK10.61421449
84MAP3K90.59844165
85PIM10.58664170
86BLK0.58478675
87MARK20.55543987
88PAK40.55159354
89TNK20.54827664
90RPS6KA20.53756122
91IKBKE0.52728267
92FGFR20.52692997
93STK40.52456888
94PDPK10.51973387
95TESK10.51644438
96CDK70.51552327
97MARK30.51209476
98MAP3K20.50213059
99LYN0.50032445
100DAPK20.48889877
101BRAF0.46212466
102FGR0.45848010
103PAK20.44854453
104PRKD10.43954367
105MAP3K10.43594049
106DYRK1B0.42966445
107BRD40.42822850
108STK110.42064762
109KIT0.40491898
110PRKD20.40240905
111EGFR0.40140309
112MAP3K60.39919651
113LMTK20.39160234
114MAPKAPK30.38660035
115MAPKAPK20.38352576
116MAPK120.38227980
117RPS6KA10.37382428
118IKBKB0.37369296
119CDK90.36671488
120RPS6KA60.36602332
121MAPK40.35775236
122RPS6KL10.35316641
123RPS6KC10.35316641
124MAPK70.35166993
125PTK20.34465250
126CHUK0.34259468
127MATK0.33338287
128PASK0.33246265
129TXK0.33155171
130FYN0.32602408

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.72604863
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36909947
3Other glycan degradation_Homo sapiens_hsa005112.29445868
4B cell receptor signaling pathway_Homo sapiens_hsa046622.23559212
5Primary immunodeficiency_Homo sapiens_hsa053402.15945279
6Chronic myeloid leukemia_Homo sapiens_hsa052201.87507100
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67196075
8Osteoclast differentiation_Homo sapiens_hsa043801.63984817
9Lysine degradation_Homo sapiens_hsa003101.60970145
10Non-small cell lung cancer_Homo sapiens_hsa052231.57285350
11T cell receptor signaling pathway_Homo sapiens_hsa046601.55409608
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53957803
13Acute myeloid leukemia_Homo sapiens_hsa052211.50734288
14mTOR signaling pathway_Homo sapiens_hsa041501.47196628
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43583702
16Insulin resistance_Homo sapiens_hsa049311.39878104
17Arginine biosynthesis_Homo sapiens_hsa002201.37681995
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35135558
19Type II diabetes mellitus_Homo sapiens_hsa049301.27434820
20VEGF signaling pathway_Homo sapiens_hsa043701.27030859
21Bladder cancer_Homo sapiens_hsa052191.25470217
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.25202007
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25163283
24Herpes simplex infection_Homo sapiens_hsa051681.24475536
25Leishmaniasis_Homo sapiens_hsa051401.24012043
26Glioma_Homo sapiens_hsa052141.21162639
27Staphylococcus aureus infection_Homo sapiens_hsa051501.17935235
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16673444
29Pancreatic cancer_Homo sapiens_hsa052121.16268372
30Antigen processing and presentation_Homo sapiens_hsa046121.15384425
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14125413
32Toxoplasmosis_Homo sapiens_hsa051451.11676098
33Pentose phosphate pathway_Homo sapiens_hsa000301.09404749
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.09056245
35Thyroid cancer_Homo sapiens_hsa052161.08877268
36Platelet activation_Homo sapiens_hsa046111.08388474
37Allograft rejection_Homo sapiens_hsa053301.08328285
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.07524672
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07121595
40Dorso-ventral axis formation_Homo sapiens_hsa043201.06282267
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.05649905
42Chemokine signaling pathway_Homo sapiens_hsa040621.02624305
43Bile secretion_Homo sapiens_hsa049761.02026168
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01463668
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01133099
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01031448
47Prolactin signaling pathway_Homo sapiens_hsa049171.00395382
48Autoimmune thyroid disease_Homo sapiens_hsa053201.00160794
49Endometrial cancer_Homo sapiens_hsa052130.98940256
50Graft-versus-host disease_Homo sapiens_hsa053320.95951014
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95518509
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95034504
53Measles_Homo sapiens_hsa051620.94480330
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94312903
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93780025
56Hematopoietic cell lineage_Homo sapiens_hsa046400.93154795
57Insulin signaling pathway_Homo sapiens_hsa049100.91610642
58Estrogen signaling pathway_Homo sapiens_hsa049150.90493769
59Epstein-Barr virus infection_Homo sapiens_hsa051690.89720376
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.89331128
61GnRH signaling pathway_Homo sapiens_hsa049120.89253797
62Prion diseases_Homo sapiens_hsa050200.88419976
63Prostate cancer_Homo sapiens_hsa052150.88085713
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87519481
65Viral myocarditis_Homo sapiens_hsa054160.86350565
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.86273620
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86216879
68ABC transporters_Homo sapiens_hsa020100.84868661
69Hepatitis B_Homo sapiens_hsa051610.84827599
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.84645937
71Malaria_Homo sapiens_hsa051440.84632894
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.83082896
73Colorectal cancer_Homo sapiens_hsa052100.82449873
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81456326
75Fructose and mannose metabolism_Homo sapiens_hsa000510.79957839
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77814298
77Proteoglycans in cancer_Homo sapiens_hsa052050.77327715
78Small cell lung cancer_Homo sapiens_hsa052220.76591819
79PPAR signaling pathway_Homo sapiens_hsa033200.75989329
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75510315
81Renal cell carcinoma_Homo sapiens_hsa052110.75484243
82AMPK signaling pathway_Homo sapiens_hsa041520.74906189
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74702210
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.73122495
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73077976
86Apoptosis_Homo sapiens_hsa042100.72748902
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72427791
88Fatty acid degradation_Homo sapiens_hsa000710.71854443
89Notch signaling pathway_Homo sapiens_hsa043300.71751861
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70698758
91Salmonella infection_Homo sapiens_hsa051320.70373879
92Glucagon signaling pathway_Homo sapiens_hsa049220.69529021
93HIF-1 signaling pathway_Homo sapiens_hsa040660.69257676
94Tuberculosis_Homo sapiens_hsa051520.68457353
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68308659
96Lysosome_Homo sapiens_hsa041420.67711880
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.67633323
98Caffeine metabolism_Homo sapiens_hsa002320.64496616
99Influenza A_Homo sapiens_hsa051640.64421308
100Viral carcinogenesis_Homo sapiens_hsa052030.63773214
101Galactose metabolism_Homo sapiens_hsa000520.63550019
102Focal adhesion_Homo sapiens_hsa045100.63472909
103HTLV-I infection_Homo sapiens_hsa051660.63263331
104FoxO signaling pathway_Homo sapiens_hsa040680.62845639
105TNF signaling pathway_Homo sapiens_hsa046680.61963012
106Endocytosis_Homo sapiens_hsa041440.61936664
107Inositol phosphate metabolism_Homo sapiens_hsa005620.61192734
108Complement and coagulation cascades_Homo sapiens_hsa046100.61087240
109Long-term potentiation_Homo sapiens_hsa047200.60489781
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59214294
111Shigellosis_Homo sapiens_hsa051310.58016289
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56957024
113Selenocompound metabolism_Homo sapiens_hsa004500.56878948
114ErbB signaling pathway_Homo sapiens_hsa040120.56535653
115African trypanosomiasis_Homo sapiens_hsa051430.56471451
116MicroRNAs in cancer_Homo sapiens_hsa052060.56114342
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55600575
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55232379
119Tryptophan metabolism_Homo sapiens_hsa003800.55150968
120Pertussis_Homo sapiens_hsa051330.54943765
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.54834549
122Legionellosis_Homo sapiens_hsa051340.54611771
123Amoebiasis_Homo sapiens_hsa051460.54079555
124Gastric acid secretion_Homo sapiens_hsa049710.54026746
125Biosynthesis of amino acids_Homo sapiens_hsa012300.52762560
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52483694
127Choline metabolism in cancer_Homo sapiens_hsa052310.51683308
128Hepatitis C_Homo sapiens_hsa051600.49615284
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49420364
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.47894741

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