PPP6R3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.57759782
2nuclear pore organization (GO:0006999)5.37643989
3non-recombinational repair (GO:0000726)4.51960609
4double-strand break repair via nonhomologous end joining (GO:0006303)4.51960609
5protein localization to kinetochore (GO:0034501)4.20757855
6mitotic sister chromatid cohesion (GO:0007064)4.18913280
7regulation of centriole replication (GO:0046599)4.17996497
8DNA unwinding involved in DNA replication (GO:0006268)4.11401424
9regulation of DNA endoreduplication (GO:0032875)4.10487650
10pore complex assembly (GO:0046931)4.10029597
11pre-miRNA processing (GO:0031054)4.01592311
12negative regulation of histone methylation (GO:0031061)3.97872709
13mitotic chromosome condensation (GO:0007076)3.97429775
14regulation of RNA export from nucleus (GO:0046831)3.95830168
15DNA double-strand break processing (GO:0000729)3.89630554
16replication fork processing (GO:0031297)3.84129914
17sister chromatid cohesion (GO:0007062)3.82678878
18mitotic nuclear envelope disassembly (GO:0007077)3.79541547
19sister chromatid segregation (GO:0000819)3.79063148
20kinetochore organization (GO:0051383)3.76011871
21spindle checkpoint (GO:0031577)3.75327271
22regulation of sister chromatid cohesion (GO:0007063)3.74994770
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.72753315
24dosage compensation (GO:0007549)3.68628079
25nuclear envelope disassembly (GO:0051081)3.62367119
26membrane disassembly (GO:0030397)3.62367119
27regulation of spindle organization (GO:0090224)3.57028014
28mitotic spindle checkpoint (GO:0071174)3.56662581
29regulation of mitotic spindle organization (GO:0060236)3.55317866
30CENP-A containing nucleosome assembly (GO:0034080)3.55204847
31folic acid-containing compound biosynthetic process (GO:0009396)3.53981296
32protein localization to chromosome, centromeric region (GO:0071459)3.49745496
33regulation of histone H3-K9 methylation (GO:0051570)3.49097022
34chromatin remodeling at centromere (GO:0031055)3.48221074
35ribosome assembly (GO:0042255)3.47745584
36regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46675753
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46270955
38positive regulation of mitotic sister chromatid separation (GO:1901970)3.46267387
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.46267387
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.46267387
41histone exchange (GO:0043486)3.45865465
42heterochromatin organization (GO:0070828)3.45486459
43melanin biosynthetic process (GO:0042438)3.42617806
44regulation of mitotic sister chromatid separation (GO:0010965)3.41719162
45regulation of mitotic sister chromatid segregation (GO:0033047)3.41719162
46regulation of sister chromatid segregation (GO:0033045)3.41719162
47genitalia morphogenesis (GO:0035112)3.41627636
48response to X-ray (GO:0010165)3.40162367
49DNA duplex unwinding (GO:0032508)3.39711491
50regulation of translational fidelity (GO:0006450)3.38671368
51DNA geometric change (GO:0032392)3.37722993
52NLS-bearing protein import into nucleus (GO:0006607)3.33490245
53lactate metabolic process (GO:0006089)3.32946501
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32219459
55positive regulation of chromosome segregation (GO:0051984)3.31374622
56DNA ligation (GO:0006266)3.30597339
57mitotic sister chromatid segregation (GO:0000070)3.29539836
58negative regulation of chromosome segregation (GO:0051985)3.28782379
59synapsis (GO:0007129)3.27786910
60paraxial mesoderm development (GO:0048339)3.26422049
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.26339664
62negative regulation of sister chromatid segregation (GO:0033046)3.26339664
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26339664
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26339664
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26339664
66melanin metabolic process (GO:0006582)3.26297481
67regulation of centrosome duplication (GO:0010824)3.24409210
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.20494007
69mitotic G2/M transition checkpoint (GO:0044818)3.20419395
70positive regulation of SMAD protein import into nucleus (GO:0060391)3.20243580
71mitotic spindle assembly checkpoint (GO:0007094)3.15341153
72regulation of centrosome cycle (GO:0046605)3.14781617
73spindle assembly checkpoint (GO:0071173)3.13945313
74chromatin assembly (GO:0031497)3.12014664
75meiotic chromosome segregation (GO:0045132)3.11342264
76monoubiquitinated protein deubiquitination (GO:0035520)3.11305274
77peptidyl-lysine dimethylation (GO:0018027)3.10569477
78regulation of nucleobase-containing compound transport (GO:0032239)3.10568101
79mRNA stabilization (GO:0048255)3.10425639
80RNA stabilization (GO:0043489)3.10425639
81histone H2A monoubiquitination (GO:0035518)3.09804316
82regulation of translational termination (GO:0006449)3.09315804
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.08921361
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.08921361
85isotype switching (GO:0045190)3.08921361
86nuclear envelope organization (GO:0006998)3.00709179
87negative regulation of DNA recombination (GO:0045910)2.99498222
88IMP biosynthetic process (GO:0006188)2.99014018
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94825505
90intra-S DNA damage checkpoint (GO:0031573)2.94273710
91histone H2A acetylation (GO:0043968)2.94234755
92protein K6-linked ubiquitination (GO:0085020)2.93848958
93DNA strand elongation involved in DNA replication (GO:0006271)2.92737614
94mitotic metaphase plate congression (GO:0007080)2.91264280
95secondary metabolite biosynthetic process (GO:0044550)2.90706708
96kinetochore assembly (GO:0051382)2.90331735
97gene silencing by RNA (GO:0031047)2.89849017
98establishment of integrated proviral latency (GO:0075713)2.85096960
99glucocorticoid receptor signaling pathway (GO:0042921)2.84849690
100DNA topological change (GO:0006265)2.84485830
101positive regulation of glycoprotein biosynthetic process (GO:0010560)2.84469517
102DNA replication-independent nucleosome assembly (GO:0006336)2.83682080
103DNA replication-independent nucleosome organization (GO:0034724)2.83682080
104mitotic G2 DNA damage checkpoint (GO:0007095)2.83396756
105somatic recombination of immunoglobulin gene segments (GO:0016447)2.81068662
106protein localization to chromosome (GO:0034502)2.80997384
107positive regulation of histone deacetylation (GO:0031065)2.80635583
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80622167
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.80622167
110nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79563021
111DNA replication-dependent nucleosome organization (GO:0034723)2.78536005
112DNA replication-dependent nucleosome assembly (GO:0006335)2.78536005
113DNA strand elongation (GO:0022616)2.76907588
114trophectodermal cell differentiation (GO:0001829)2.76309837
115double-strand break repair (GO:0006302)2.75781669
116epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75558941
117regulation of mitotic spindle checkpoint (GO:1903504)2.74046500
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74046500
119regulation of SMAD protein import into nucleus (GO:0060390)2.72970941
120DNA conformation change (GO:0071103)2.71548604
121cytoplasmic mRNA processing body assembly (GO:0033962)2.69837015
122spliceosomal tri-snRNP complex assembly (GO:0000244)2.67137949
123nucleobase biosynthetic process (GO:0046112)2.64768103
124chromosome condensation (GO:0030261)2.64618490
125regulation of gene silencing by RNA (GO:0060966)2.64239801
126regulation of posttranscriptional gene silencing (GO:0060147)2.64239801
127regulation of gene silencing by miRNA (GO:0060964)2.64239801
128regulation of chromosome segregation (GO:0051983)2.62492676
129histone mRNA catabolic process (GO:0071044)2.62386896
130gene silencing (GO:0016458)2.61992956
131histone H3-K9 demethylation (GO:0033169)2.61095108
132metaphase plate congression (GO:0051310)2.59925189
133mitotic G1 DNA damage checkpoint (GO:0031571)2.58486343
134regulation of hippo signaling (GO:0035330)2.58152925
135IMP metabolic process (GO:0046040)2.57094719
136positive regulation of protein import into nucleus, translocation (GO:0033160)2.55485926
137negative regulation of DNA repair (GO:0045738)2.54507135
138chromatin assembly or disassembly (GO:0006333)2.53997864
139translesion synthesis (GO:0019985)2.53685981
140folic acid metabolic process (GO:0046655)2.47774339
141purine nucleobase biosynthetic process (GO:0009113)2.43579914
142negative regulation of histone modification (GO:0031057)2.42104869
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41205812
144hippo signaling (GO:0035329)2.40954628
145corticosteroid receptor signaling pathway (GO:0031958)2.40781937
146regulation of mRNA stability (GO:0043488)2.40649414
147spindle assembly involved in mitosis (GO:0090307)2.39123724
148histone lysine demethylation (GO:0070076)2.35920782
149histone-serine phosphorylation (GO:0035404)2.35188606
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.34429345
151response to UV-C (GO:0010225)2.33899172
152mRNA transport (GO:0051028)2.33362804
153regulation of telomere maintenance via telomerase (GO:0032210)2.32915061
154cellular response to epidermal growth factor stimulus (GO:0071364)2.32550589
155tetrahydrofolate metabolic process (GO:0046653)2.31936466
156microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.31768420
157establishment of chromosome localization (GO:0051303)2.30411527
158histone H3-K36 demethylation (GO:0070544)2.30206708
159DNA packaging (GO:0006323)2.30050411
160attachment of spindle microtubules to kinetochore (GO:0008608)2.29737594
161embryonic process involved in female pregnancy (GO:0060136)2.28576074
162chromosome segregation (GO:0007059)2.28520341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14898157
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.60771978
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.95015771
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13679121
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05856796
6MYC_22102868_ChIP-Seq_BL_Human2.86680592
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65530638
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56505047
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38830603
10ELK1_19687146_ChIP-ChIP_HELA_Human2.33760167
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31203617
12AR_21909140_ChIP-Seq_LNCAP_Human2.28158072
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.15860975
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11046858
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10839358
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.03846945
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01794513
18PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96556640
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.93764789
20FUS_26573619_Chip-Seq_HEK293_Human1.92650329
21ZNF263_19887448_ChIP-Seq_K562_Human1.88575695
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87745143
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84415680
24CLOCK_20551151_ChIP-Seq_293T_Human1.75449149
25EWS_26573619_Chip-Seq_HEK293_Human1.72276335
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70512061
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69577406
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62457338
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.61981229
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61943247
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60652442
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60515533
33TCF7_22412390_ChIP-Seq_EML_Mouse1.60009400
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59181531
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.58577416
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58184655
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56926765
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54534052
39CIITA_25753668_ChIP-Seq_RAJI_Human1.49606291
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.48983480
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48798364
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48309382
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47652971
44VDR_21846776_ChIP-Seq_THP-1_Human1.46164040
45ZNF274_21170338_ChIP-Seq_K562_Hela1.43766725
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.42537974
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41499845
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37500935
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37457055
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.35376014
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35333762
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.34367184
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33656650
54VDR_23849224_ChIP-Seq_CD4+_Human1.33294543
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32392370
56KDM5A_27292631_Chip-Seq_BREAST_Human1.31765546
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31045930
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30655583
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29792805
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29727296
61KDM2B_26808549_Chip-Seq_DND41_Human1.29383219
62P300_19829295_ChIP-Seq_ESCs_Human1.29292132
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27832117
64GATA1_22025678_ChIP-Seq_K562_Human1.27744542
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.27377585
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27261961
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26340994
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26164899
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25729506
70VDR_22108803_ChIP-Seq_LS180_Human1.24697487
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24120345
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23191317
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.23093242
74* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22719309
75FOXP3_21729870_ChIP-Seq_TREG_Human1.21887799
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21806948
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21625734
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21007832
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20890060
80ATF3_27146783_Chip-Seq_COLON_Human1.20731917
81TAF15_26573619_Chip-Seq_HEK293_Human1.20246911
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19613049
83ER_23166858_ChIP-Seq_MCF-7_Human1.19006475
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18690736
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17934770
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17441791
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15750087
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15725622
89CHD1_26751641_Chip-Seq_LNCaP_Human1.15162307
90XRN2_22483619_ChIP-Seq_HELA_Human1.12723964
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.12453909
92IGF1R_20145208_ChIP-Seq_DFB_Human1.12002639
93NCOR1_26117541_ChIP-Seq_K562_Human1.11903106
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11863149
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11544229
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10915787
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10784717
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10619710
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10393672
100UTX_26944678_Chip-Seq_JUKART_Human1.10321941
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09249295
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09082565
103MAF_26560356_Chip-Seq_TH1_Human1.09014724
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08537192
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07582557
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.07108780
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06981976
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06579323
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06478554
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.06476330
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06197656
112GBX2_23144817_ChIP-Seq_PC3_Human1.05517958
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05398321
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05397276
115TFEB_21752829_ChIP-Seq_HELA_Human1.05139519
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04468886
117GATA6_25053715_ChIP-Seq_YYC3_Human1.04329623
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03607648
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.02935974
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02378352
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02164604
122STAT3_23295773_ChIP-Seq_U87_Human1.01966690
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99535276
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99528049
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99336738
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.99087168
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98914964
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98359612
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98211449
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98115272
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97896304
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97387980
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.97314531
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97299981
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96837313
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.96708586
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.96112740
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.96017925
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96000299
140SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95878710
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94961522
142SMAD4_21799915_ChIP-Seq_A2780_Human0.94886616
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.94660212
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94658598
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94429141
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93604590
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93314571
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93042885
149CBP_20019798_ChIP-Seq_JUKART_Human0.93042885
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92627471
151CDX2_22108803_ChIP-Seq_LS180_Human0.91791368
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91435740
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91366012
154BRD4_25478319_ChIP-Seq_HGPS_Human0.91242266
155LXR_22158963_ChIP-Seq_LIVER_Mouse0.91120755
156TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90296289
157MYB_26560356_Chip-Seq_TH1_Human0.90277788
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90269432
159P300_18555785_Chip-Seq_ESCs_Mouse0.89771232
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89307477
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.88998417
162* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88828742
163MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88227983
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.87683399
165DCP1A_22483619_ChIP-Seq_HELA_Human0.87380711
166OCT4_18555785_Chip-Seq_ESCs_Mouse0.87331338
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86794106
168SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86587403
169ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86523410
170RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86429218
171P53_22387025_ChIP-Seq_ESCs_Mouse0.86391202
172CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86163684
173TCF4_23295773_ChIP-Seq_U87_Human0.86032325
174SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85961525
175SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85360620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.09284645
2MP0003705_abnormal_hypodermis_morpholog3.54536325
3MP0010352_gastrointestinal_tract_polyps3.24093031
4MP0003693_abnormal_embryo_hatching2.70633850
5MP0003111_abnormal_nucleus_morphology2.70489179
6MP0005408_hypopigmentation2.65287294
7MP0005076_abnormal_cell_differentiation2.60988211
8MP0010234_abnormal_vibrissa_follicle2.59346179
9MP0005075_abnormal_melanosome_morpholog2.59015850
10MP0000015_abnormal_ear_pigmentation2.43309933
11MP0003077_abnormal_cell_cycle2.37549884
12MP0010094_abnormal_chromosome_stability2.33969512
13MP0010307_abnormal_tumor_latency2.28101126
14MP0004957_abnormal_blastocyst_morpholog2.25122079
15MP0008877_abnormal_DNA_methylation2.15499573
16MP0001730_embryonic_growth_arrest2.07298865
17MP0002009_preneoplasia2.02521002
18MP0002254_reproductive_system_inflammat1.96698006
19MP0002102_abnormal_ear_morphology1.90184171
20MP0003123_paternal_imprinting1.83320070
21MP0003566_abnormal_cell_adhesion1.82620039
22MP0003300_gastrointestinal_ulcer1.80132254
23MP0004197_abnormal_fetal_growth/weight/1.79534851
24MP0008057_abnormal_DNA_replication1.77763316
25MP0005380_embryogenesis_phenotype1.75431044
26MP0001672_abnormal_embryogenesis/_devel1.75431044
27MP0000350_abnormal_cell_proliferation1.73445518
28MP0003984_embryonic_growth_retardation1.72645251
29MP0002088_abnormal_embryonic_growth/wei1.71740288
30MP0002086_abnormal_extraembryonic_tissu1.69943949
31MP0004808_abnormal_hematopoietic_stem1.67404533
32MP0000537_abnormal_urethra_morphology1.63619453
33MP0002877_abnormal_melanocyte_morpholog1.63601080
34MP0003786_premature_aging1.59487162
35MP0009278_abnormal_bone_marrow1.59296833
36MP0005171_absent_coat_pigmentation1.56197290
37MP0009697_abnormal_copulation1.55989628
38MP0001697_abnormal_embryo_size1.55530340
39MP0003567_abnormal_fetal_cardiomyocyte1.54264253
40MP0002084_abnormal_developmental_patter1.53638927
41MP0001849_ear_inflammation1.51277032
42MP0005174_abnormal_tail_pigmentation1.50039836
43MP0000427_abnormal_hair_cycle1.49476344
44MP0004381_abnormal_hair_follicle1.48931801
45MP0003136_yellow_coat_color1.48405996
46MP0004264_abnormal_extraembryonic_tissu1.47136607
47MP0003941_abnormal_skin_development1.43530253
48MP0000733_abnormal_muscle_development1.42152943
49MP0003718_maternal_effect1.41363391
50MP0000383_abnormal_hair_follicle1.40873776
51MP0002085_abnormal_embryonic_tissue1.40528550
52MP0008007_abnormal_cellular_replicative1.40051155
53MP0009053_abnormal_anal_canal1.39663126
54MP0002080_prenatal_lethality1.35808126
55MP0002396_abnormal_hematopoietic_system1.34634136
56MP0005360_urolithiasis1.34461968
57MP0002139_abnormal_hepatobiliary_system1.32108033
58MP0010030_abnormal_orbit_morphology1.31268091
59MP0000647_abnormal_sebaceous_gland1.30716870
60MP0002095_abnormal_skin_pigmentation1.30625471
61MP0003787_abnormal_imprinting1.30277313
62MP0009780_abnormal_chondrocyte_physiolo1.30018468
63MP0009672_abnormal_birth_weight1.27215636
64MP0006054_spinal_hemorrhage1.25495102
65MP0002938_white_spotting1.24205777
66MP0003890_abnormal_embryonic-extraembry1.23031145
67MP0001324_abnormal_eye_pigmentation1.22749142
68MP0010630_abnormal_cardiac_muscle1.20224443
69MP0005023_abnormal_wound_healing1.19805450
70MP0009840_abnormal_foam_cell1.19440357
71MP0002090_abnormal_vision1.18862838
72MP0001915_intracranial_hemorrhage1.17073794
73MP0005187_abnormal_penis_morphology1.15471580
74MP0004084_abnormal_cardiac_muscle1.15120383
75MP0009703_decreased_birth_body1.13778824
76MP0003252_abnormal_bile_duct1.13208213
77MP0003119_abnormal_digestive_system1.12327387
78MP0004185_abnormal_adipocyte_glucose1.12067691
79MP0002006_tumorigenesis1.07576327
80MP0003121_genomic_imprinting1.04529882
81MP0006072_abnormal_retinal_apoptosis1.03256055
82MP0001293_anophthalmia1.01911464
83MP0003806_abnormal_nucleotide_metabolis1.01817727
84MP0005365_abnormal_bile_salt1.01487719
85MP0001545_abnormal_hematopoietic_system1.01078707
86MP0005397_hematopoietic_system_phenotyp1.01078707
87MP0010368_abnormal_lymphatic_system1.00957289
88MP0000428_abnormal_craniofacial_morphol1.00682966
89MP0002925_abnormal_cardiovascular_devel1.00274295
90MP0003195_calcinosis0.98828350
91MP0008961_abnormal_basal_metabolism0.98638345
92MP0002092_abnormal_eye_morphology0.98456872
93MP0000490_abnormal_crypts_of0.95956958
94MP0005666_abnormal_adipose_tissue0.94893867
95MP0004233_abnormal_muscle_weight0.93638707
96MP0000569_abnormal_digit_pigmentation0.92745298
97MP0002075_abnormal_coat/hair_pigmentati0.92568595
98MP0001661_extended_life_span0.91872366
99MP0003115_abnormal_respiratory_system0.91066071
100MP0001929_abnormal_gametogenesis0.89747330
101MP0005253_abnormal_eye_physiology0.87944441
102MP0000266_abnormal_heart_morphology0.87698536
103MP0010678_abnormal_skin_adnexa0.87135658
104MP0003950_abnormal_plasma_membrane0.87128091
105MP0003935_abnormal_craniofacial_develop0.86749203
106MP0002019_abnormal_tumor_incidence0.86656455
107MP0001186_pigmentation_phenotype0.85093560
108MP0000358_abnormal_cell_content/0.84788556
109MP0002166_altered_tumor_susceptibility0.84400602
110MP0008058_abnormal_DNA_repair0.84327242
111MP0000313_abnormal_cell_death0.84015529
112MP0005220_abnormal_exocrine_pancreas0.82092693
113MP0003646_muscle_fatigue0.81988073
114MP0008932_abnormal_embryonic_tissue0.81686802
115MP0005395_other_phenotype0.80883993
116MP0000609_abnormal_liver_physiology0.80771940
117MP0005367_renal/urinary_system_phenotyp0.80364470
118MP0000516_abnormal_urinary_system0.80364470
119MP0000598_abnormal_liver_morphology0.79676262
120MP0002269_muscular_atrophy0.79487661
121MP0004087_abnormal_muscle_fiber0.78763357
122MP0000703_abnormal_thymus_morphology0.78084519
123MP0003091_abnormal_cell_migration0.77875976
124MP0005379_endocrine/exocrine_gland_phen0.77707128
125MP0005248_abnormal_Harderian_gland0.75706823
126MP0002697_abnormal_eye_size0.75602488
127MP0005621_abnormal_cell_physiology0.74908617
128MP0003191_abnormal_cellular_cholesterol0.74757379
129MP0003221_abnormal_cardiomyocyte_apopto0.73703316
130MP0003943_abnormal_hepatobiliary_system0.72996702
131MP0003453_abnormal_keratinocyte_physiol0.72791663
132MP0000371_diluted_coat_color0.72301433
133MP0004130_abnormal_muscle_cell0.71706770
134MP0000477_abnormal_intestine_morphology0.71637501
135MP0010329_abnormal_lipoprotein_level0.71032485
136MP0006035_abnormal_mitochondrial_morpho0.70989663
137MP0005384_cellular_phenotype0.70750499
138MP0005085_abnormal_gallbladder_physiolo0.69691665
139MP0005375_adipose_tissue_phenotype0.66994053
140MP0003937_abnormal_limbs/digits/tail_de0.66817685
141MP0004947_skin_inflammation0.66559203
142MP0002128_abnormal_blood_circulation0.66200793
143MP0000377_abnormal_hair_follicle0.65781832
144MP0000653_abnormal_sex_gland0.63439032
145MP0001145_abnormal_male_reproductive0.63268079
146MP0001286_abnormal_eye_development0.62527294
147MP0003656_abnormal_erythrocyte_physiolo0.62237555
148MP0002210_abnormal_sex_determination0.59317914

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41563093
2Chromsome breakage (HP:0040012)4.24030240
3Abnormality of chromosome stability (HP:0003220)4.09789338
4Neoplasm of the adrenal cortex (HP:0100641)3.91928910
5Nephroblastoma (Wilms tumor) (HP:0002667)3.80083605
6Embryonal renal neoplasm (HP:0011794)3.61251887
7Ependymoma (HP:0002888)3.18992200
8Intestinal atresia (HP:0011100)3.16388595
9Papillary thyroid carcinoma (HP:0002895)3.12159346
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.03725449
11Abnormality of the fingertips (HP:0001211)3.03135782
12Abnormality of the preputium (HP:0100587)3.01861299
13Meckel diverticulum (HP:0002245)2.95908656
14Volvulus (HP:0002580)2.94847031
15Abnormality of the ileum (HP:0001549)2.88792784
16Short 4th metacarpal (HP:0010044)2.82773897
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82773897
18Duodenal stenosis (HP:0100867)2.81543842
19Small intestinal stenosis (HP:0012848)2.81543842
20Cerebral aneurysm (HP:0004944)2.77087192
21Neoplasm of the adrenal gland (HP:0100631)2.75963923
22Abnormal lung lobation (HP:0002101)2.75014996
23Aplasia/Hypoplasia of the macula (HP:0008059)2.74607840
24Abnormal auditory evoked potentials (HP:0006958)2.73845595
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.71678664
26Hypoplasia of the fovea (HP:0007750)2.71678664
27Breast carcinoma (HP:0003002)2.66426764
28Pancreatic islet-cell hyperplasia (HP:0004510)2.64763600
29Thyroid carcinoma (HP:0002890)2.64024727
30Abnormality of the duodenum (HP:0002246)2.60578415
31Astrocytoma (HP:0009592)2.56350212
32Abnormality of the astrocytes (HP:0100707)2.56350212
33Curly hair (HP:0002212)2.55512051
34Hyperacusis (HP:0010780)2.55404808
35Sloping forehead (HP:0000340)2.53768208
36Biliary tract neoplasm (HP:0100574)2.51905603
37Increased nuchal translucency (HP:0010880)2.50961666
38Subacute progressive viral hepatitis (HP:0006572)2.50360931
39Colon cancer (HP:0003003)2.49994251
40Abnormality of the fovea (HP:0000493)2.47752134
41Deviation of the thumb (HP:0009603)2.46502168
42Myelodysplasia (HP:0002863)2.45953214
43Heterotopia (HP:0002282)2.45447136
44Aplasia/Hypoplasia affecting the retina (HP:0008061)2.44882349
45Blue irides (HP:0000635)2.44231553
46Freckling (HP:0001480)2.42807677
47Abnormality of the 4th metacarpal (HP:0010012)2.41708214
48Clubbing of toes (HP:0100760)2.40357587
49Malignant gastrointestinal tract tumors (HP:0006749)2.39354329
50Gastrointestinal carcinoma (HP:0002672)2.39354329
51Proximal placement of thumb (HP:0009623)2.39289486
52Transitional cell carcinoma of the bladder (HP:0006740)2.39027566
53Rectal prolapse (HP:0002035)2.37801064
54Hematochezia (HP:0002573)2.35226210
55Albinism (HP:0001022)2.32765969
56Acute myeloid leukemia (HP:0004808)2.29791759
57Ankle contracture (HP:0006466)2.28693262
58Pseudobulbar signs (HP:0002200)2.28475549
59Spastic diplegia (HP:0001264)2.28014029
60Embryonal neoplasm (HP:0002898)2.26551712
61Long eyelashes (HP:0000527)2.24916148
62Neoplasm of the colon (HP:0100273)2.23476100
63Medulloblastoma (HP:0002885)2.23210629
64Aneurysm (HP:0002617)2.22651115
65Long clavicles (HP:0000890)2.22623046
66Abnormality of chromosome segregation (HP:0002916)2.19815293
67Selective tooth agenesis (HP:0001592)2.18619268
68Bladder carcinoma (HP:0002862)2.17841867
69Bladder neoplasm (HP:0009725)2.17841867
70Glioma (HP:0009733)2.13879267
71White forelock (HP:0002211)2.10915484
72Lymphangioma (HP:0100764)2.09979168
73Aqueductal stenosis (HP:0002410)2.09976004
74Patchy hypopigmentation of hair (HP:0011365)2.09436515
75Progressive inability to walk (HP:0002505)2.07960920
76Ocular albinism (HP:0001107)2.07608753
77Neoplasm of the oral cavity (HP:0100649)2.06283535
78Abnormality of the pancreatic islet cells (HP:0006476)2.05452803
79Abnormality of endocrine pancreas physiology (HP:0012093)2.05452803
80Sandal gap (HP:0001852)2.03345077
81Deep philtrum (HP:0002002)2.02965143
82Esophageal varix (HP:0002040)2.02609281
83Iris hypopigmentation (HP:0007730)2.02470581
84Hand muscle atrophy (HP:0009130)2.02052021
85Shallow orbits (HP:0000586)2.01468320
86Cortical dysplasia (HP:0002539)2.00820346
87Abnormal hair whorl (HP:0010721)1.98648228
88Renovascular hypertension (HP:0100817)1.98385406
89Renal duplication (HP:0000075)1.97799237
90Enlarged penis (HP:0000040)1.97583031
91Hyperinsulinemic hypoglycemia (HP:0000825)1.97005237
92Macroorchidism (HP:0000053)1.96264906
93Prominent nose (HP:0000448)1.96070651
94High pitched voice (HP:0001620)1.95954279
95Metaphyseal cupping (HP:0003021)1.92576736
96Aortic aneurysm (HP:0004942)1.92041546
97Ectopic kidney (HP:0000086)1.91935509
98Low anterior hairline (HP:0000294)1.91230423
99Thyroiditis (HP:0100646)1.90933733
100Abnormality of the labia minora (HP:0012880)1.90799713
101Bifid tongue (HP:0010297)1.90490802
102Back pain (HP:0003418)1.90482695
103Hypoglycemic seizures (HP:0002173)1.90181506
104Generalized hypopigmentation (HP:0007513)1.90082843
105Fair hair (HP:0002286)1.89995273
106Ulnar bowing (HP:0003031)1.89388111
107Pelvic girdle muscle weakness (HP:0003749)1.89326543
108Abnormal foot bone ossification (HP:0010675)1.88857650
109Cutis marmorata (HP:0000965)1.88525797
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88168045
111Anal stenosis (HP:0002025)1.86696670
112Intestinal polyp (HP:0005266)1.86361239
113Mitral valve prolapse (HP:0001634)1.85132309
114Rhabdomyosarcoma (HP:0002859)1.84649593
115Abnormal biliary tract morphology (HP:0012440)1.83797799
116Intestinal polyposis (HP:0200008)1.83539245
117Skull defect (HP:0001362)1.82064345
118Abnormality of methionine metabolism (HP:0010901)1.81881486
119Uterine neoplasm (HP:0010784)1.81121900
120Elfin facies (HP:0004428)1.79545684
121Neoplasm of striated muscle (HP:0009728)1.79354734
122Missing ribs (HP:0000921)1.78376187
123Generalized hypopigmentation of hair (HP:0011358)1.78373114
124Abnormality of the lower motor neuron (HP:0002366)1.77388613
125Hypochromic microcytic anemia (HP:0004840)1.77105510
126Clitoromegaly (HP:0000057)1.76571470
127Cystic hygroma (HP:0000476)1.74742151
128Gaze-evoked nystagmus (HP:0000640)1.73865235
129Broad thumb (HP:0011304)1.73750654
130Bicuspid aortic valve (HP:0001647)1.73620099
131Basal cell carcinoma (HP:0002671)1.73463489
132Upper limb amyotrophy (HP:0009129)1.73329997
133Distal upper limb amyotrophy (HP:0007149)1.73329997
134Dyschromatopsia (HP:0007641)1.73137985
135Truncal obesity (HP:0001956)1.72493319
136Increased density of long bones (HP:0006392)1.71672608
137Hypoplastic labia majora (HP:0000059)1.70959624
138Hypobetalipoproteinemia (HP:0003563)1.70602984
139Bowel diverticulosis (HP:0005222)1.70251551
140Multiple enchondromatosis (HP:0005701)1.70232859
141Broad palm (HP:0001169)1.69090295
142Increased connective tissue (HP:0009025)1.68950864
143Asymmetry of the thorax (HP:0001555)1.68489830
144Neoplasm of the thyroid gland (HP:0100031)1.67982123
145Neoplasm of the small intestine (HP:0100833)1.67927263
146Facial cleft (HP:0002006)1.66682735
147Urethral obstruction (HP:0000796)1.65481348
148Ovarian neoplasm (HP:0100615)1.64183680
149Abnormality of the calcaneus (HP:0008364)1.63494835
150Abnormality of the peritoneum (HP:0002585)1.62891970
151Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62861691
152Short 1st metacarpal (HP:0010034)1.62861691
153Protrusio acetabuli (HP:0003179)1.62275102
154Polycythemia (HP:0001901)1.61725700
155Cafe-au-lait spot (HP:0000957)1.61411534
156Hypopigmentation of the fundus (HP:0007894)1.60174424
157Fibrous tissue neoplasm (HP:0012316)1.59606782
158Fibroma (HP:0010614)1.59420167
159Obsessive-compulsive behavior (HP:0000722)1.58244937
160Skin tags (HP:0010609)1.57204393
161Vertebral arch anomaly (HP:0008438)1.57129304
162Dilatation of the ascending aorta (HP:0005111)1.56309547
163Neoplasm of the rectum (HP:0100743)1.55335798
164Overlapping toe (HP:0001845)1.53318567
165Hyperglycemia (HP:0003074)1.52859524
166Cutaneous melanoma (HP:0012056)1.52179232
167Short phalanx of the thumb (HP:0009660)1.51326090
168Right ventricular cardiomyopathy (HP:0011663)1.49323806
169Uterine leiomyosarcoma (HP:0002891)1.49107300
170Leiomyosarcoma (HP:0100243)1.49107300
171Narrow palate (HP:0000189)1.48944202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.82554676
2EIF2AK33.36955335
3PKN23.32013855
4EEF2K3.24220007
5MST43.09605826
6MAP3K102.99783051
7TRIB32.99423966
8MKNK22.85885309
9NEK22.66000323
10BMPR1B2.62819794
11EIF2AK12.59074325
12CDC72.56286545
13ERBB32.50086422
14LATS12.39763089
15TRIM282.33642637
16SCYL22.07459769
17NEK11.97860774
18TTN1.94026998
19PLK41.90960825
20PTK61.90146089
21STK101.69111036
22TTK1.65651279
23PLK21.62881373
24PDGFRA1.61113357
25RPS6KB21.60198365
26FGFR41.57677011
27PBK1.55207935
28CDK41.55024465
29CDK61.53223130
30EPHA21.53194561
31WEE11.52566345
32PASK1.51480424
33BRD41.49499002
34ZAK1.47167722
35TGFBR11.45381591
36STK31.45158849
37FER1.45071545
38NLK1.43600415
39SIK11.42847468
40STK391.41777156
41MTOR1.39206970
42RIPK11.37977791
43MAP3K81.37753104
44NUAK11.37078850
45ERN11.34143016
46TNIK1.31075251
47WNK31.27573992
48MST1R1.27486601
49CAMK1D1.25377027
50FGFR31.22893830
51FLT31.21617352
52PAK41.20393151
53ALK1.19959475
54SIK31.19838028
55LRRK21.19645872
56TAF11.17004438
57RPS6KA41.13157294
58AURKB1.10208926
59STK41.08430307
60BUB11.07856313
61EIF2AK21.06513360
62ATR1.06075835
63BCR1.05189815
64AKT31.05156252
65MELK1.00996091
66TGFBR21.00052286
67FGFR20.98856628
68CHEK10.98752845
69ACVR1B0.98272549
70TSSK60.97532092
71MAP2K30.96509682
72ICK0.93245259
73PLK10.87927890
74PNCK0.87702137
75FGFR10.86737962
76BRSK20.81929327
77FRK0.80947240
78MAP3K20.79950139
79NEK60.79587551
80YES10.79496563
81PDGFRB0.79041748
82CHEK20.78855473
83SRPK10.78144901
84CDK70.76656208
85ATM0.71942711
86CSNK1G10.71776025
87MARK30.69883273
88CDK20.68990239
89TIE10.67853195
90MAP4K10.67691316
91TYRO30.66779693
92BMX0.64693247
93VRK10.63207501
94PAK30.63173858
95PIM10.62115528
96STK38L0.61782394
97ERBB40.61057722
98BMPR20.60438439
99PLK30.59908049
100MAP3K120.59763001
101PAK20.58903483
102MAP3K70.58116021
103MAPK110.57502424
104CDK80.57460377
105NEK90.57150770
106RET0.56546358
107TRPM70.55766534
108DYRK30.55721470
109MAP3K40.55109695
110OXSR10.54980695
111CAMK1G0.54949989
112CDK90.54025140
113AKT20.53762243
114KSR10.53389523
115TYK20.51805422
116CHUK0.50906735
117PDK20.50726726
118CDK10.50101532
119DYRK1B0.49852607
120MAP4K20.49742817
121CCNB10.49233658
122SGK30.48317053
123EPHA30.48306049
124CDK30.46001005
125JAK30.45803819
126PRKAA10.44560260
127PTK20.44000201
128DMPK0.43774003
129CSNK1D0.43167333
130MKNK10.42661250
131STK240.42126376
132PRKCI0.42121038
133MAP3K30.40961346
134GRK60.39538998
135ITK0.39430408
136PDK30.39253880
137PDK40.39253880
138RPS6KB10.39170349
139BRSK10.38945926
140CLK10.38775532
141JAK20.38317197
142JAK10.38049562
143GRK10.37597869
144CSNK1A1L0.37397332
145PRKDC0.36574326
146EGFR0.35963640
147PRKAA20.35274288
148MAPK140.35272009
149MET0.34287916
150INSRR0.32868549
151MAPK10.31820688

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.67811984
2Homologous recombination_Homo sapiens_hsa034402.56348932
3One carbon pool by folate_Homo sapiens_hsa006702.34178100
4Proteasome_Homo sapiens_hsa030502.22689685
5Basal transcription factors_Homo sapiens_hsa030222.14082692
6Cell cycle_Homo sapiens_hsa041102.05668446
7Protein export_Homo sapiens_hsa030602.05028395
8RNA transport_Homo sapiens_hsa030132.02070941
9Lysine degradation_Homo sapiens_hsa003101.95912793
10Vitamin B6 metabolism_Homo sapiens_hsa007501.95554532
11Nitrogen metabolism_Homo sapiens_hsa009101.92104970
12DNA replication_Homo sapiens_hsa030301.89882057
13Selenocompound metabolism_Homo sapiens_hsa004501.83466483
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72455504
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70700326
16Mismatch repair_Homo sapiens_hsa034301.57387945
17mTOR signaling pathway_Homo sapiens_hsa041501.52871809
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51313878
19Small cell lung cancer_Homo sapiens_hsa052221.50974258
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48338676
21Systemic lupus erythematosus_Homo sapiens_hsa053221.47047733
22Spliceosome_Homo sapiens_hsa030401.46162485
23Chronic myeloid leukemia_Homo sapiens_hsa052201.44877008
24MicroRNAs in cancer_Homo sapiens_hsa052061.44118485
25mRNA surveillance pathway_Homo sapiens_hsa030151.43300598
26Adherens junction_Homo sapiens_hsa045201.41028165
27Base excision repair_Homo sapiens_hsa034101.36727510
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35510767
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34829008
30Steroid biosynthesis_Homo sapiens_hsa001001.34799132
31Biosynthesis of amino acids_Homo sapiens_hsa012301.34783906
32Viral carcinogenesis_Homo sapiens_hsa052031.34766188
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25831631
34p53 signaling pathway_Homo sapiens_hsa041151.24232727
35Insulin resistance_Homo sapiens_hsa049311.20655078
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20180955
37Fatty acid degradation_Homo sapiens_hsa000711.17666732
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16797841
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.15363183
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15073082
41Notch signaling pathway_Homo sapiens_hsa043301.10376134
42Carbon metabolism_Homo sapiens_hsa012001.10111919
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07636492
44Inositol phosphate metabolism_Homo sapiens_hsa005621.07021381
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06355354
46Non-small cell lung cancer_Homo sapiens_hsa052231.04960042
47Proteoglycans in cancer_Homo sapiens_hsa052051.04387689
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01924155
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01254683
50HTLV-I infection_Homo sapiens_hsa051661.00297273
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99667167
52Circadian rhythm_Homo sapiens_hsa047100.99039733
53Arginine biosynthesis_Homo sapiens_hsa002200.98633826
54Thyroid cancer_Homo sapiens_hsa052160.98129931
55Endometrial cancer_Homo sapiens_hsa052130.97079142
56Viral myocarditis_Homo sapiens_hsa054160.95440326
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.94304878
58Colorectal cancer_Homo sapiens_hsa052100.93610684
59Antigen processing and presentation_Homo sapiens_hsa046120.91517218
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91492685
61Hippo signaling pathway_Homo sapiens_hsa043900.91170792
62AMPK signaling pathway_Homo sapiens_hsa041520.89652845
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87451936
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86744703
65Herpes simplex infection_Homo sapiens_hsa051680.86259076
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.86005902
67Focal adhesion_Homo sapiens_hsa045100.85366497
68Pentose phosphate pathway_Homo sapiens_hsa000300.84765538
69FoxO signaling pathway_Homo sapiens_hsa040680.82580253
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82248379
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81656379
72Pancreatic cancer_Homo sapiens_hsa052120.79491730
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.79011209
74Butanoate metabolism_Homo sapiens_hsa006500.78414544
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78339121
76Bladder cancer_Homo sapiens_hsa052190.78080865
77Acute myeloid leukemia_Homo sapiens_hsa052210.77840327
78Non-homologous end-joining_Homo sapiens_hsa034500.75891034
79RNA degradation_Homo sapiens_hsa030180.75797653
80Basal cell carcinoma_Homo sapiens_hsa052170.75083731
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73678479
82Sphingolipid metabolism_Homo sapiens_hsa006000.72977869
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72253139
84Alcoholism_Homo sapiens_hsa050340.71429555
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71058653
86Pyruvate metabolism_Homo sapiens_hsa006200.70924268
87Prostate cancer_Homo sapiens_hsa052150.70515434
88Fatty acid elongation_Homo sapiens_hsa000620.70246995
89HIF-1 signaling pathway_Homo sapiens_hsa040660.69223300
90Insulin signaling pathway_Homo sapiens_hsa049100.68952655
91RNA polymerase_Homo sapiens_hsa030200.68649987
92TGF-beta signaling pathway_Homo sapiens_hsa043500.68441948
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67652167
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.67452844
95Nucleotide excision repair_Homo sapiens_hsa034200.67189729
96N-Glycan biosynthesis_Homo sapiens_hsa005100.66556261
97Apoptosis_Homo sapiens_hsa042100.65033122
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64247356
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.64057202
100Caffeine metabolism_Homo sapiens_hsa002320.63869045
101Toxoplasmosis_Homo sapiens_hsa051450.63714069
102Tryptophan metabolism_Homo sapiens_hsa003800.63031066
103Hepatitis B_Homo sapiens_hsa051610.63000475
104Fatty acid metabolism_Homo sapiens_hsa012120.62880068
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61195561
106PPAR signaling pathway_Homo sapiens_hsa033200.60589785
107Legionellosis_Homo sapiens_hsa051340.59740015
108Oocyte meiosis_Homo sapiens_hsa041140.57709645
109Tight junction_Homo sapiens_hsa045300.57690920
110Epstein-Barr virus infection_Homo sapiens_hsa051690.57238018
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56584644
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56458104
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.56036810
114Purine metabolism_Homo sapiens_hsa002300.55375941
115Fat digestion and absorption_Homo sapiens_hsa049750.54141531
116Pathways in cancer_Homo sapiens_hsa052000.53598719
117Propanoate metabolism_Homo sapiens_hsa006400.53247279
118ABC transporters_Homo sapiens_hsa020100.52543865
119Glucagon signaling pathway_Homo sapiens_hsa049220.52187497
120Sulfur metabolism_Homo sapiens_hsa009200.51788918
121Prolactin signaling pathway_Homo sapiens_hsa049170.50236310
122Dorso-ventral axis formation_Homo sapiens_hsa043200.50093755
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49817717
124Wnt signaling pathway_Homo sapiens_hsa043100.49424258
125Pyrimidine metabolism_Homo sapiens_hsa002400.48743139
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48462309
127Renal cell carcinoma_Homo sapiens_hsa052110.48096128
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.47310224
129Regulation of autophagy_Homo sapiens_hsa041400.46146444
130Fatty acid biosynthesis_Homo sapiens_hsa000610.44090706
131Melanoma_Homo sapiens_hsa052180.42822914
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38154494
133Glioma_Homo sapiens_hsa052140.35216259
134Glutathione metabolism_Homo sapiens_hsa004800.31656084
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30688797

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