PPRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.98010408
2nuclear pore complex assembly (GO:0051292)4.91350527
3protein localization to kinetochore (GO:0034501)4.68223511
4mitotic nuclear envelope disassembly (GO:0007077)4.35619545
5DNA unwinding involved in DNA replication (GO:0006268)4.34599571
6nucleobase biosynthetic process (GO:0046112)4.13029855
7pre-miRNA processing (GO:0031054)4.11582125
8membrane disassembly (GO:0030397)4.04926588
9nuclear envelope disassembly (GO:0051081)4.04926588
10formation of translation preinitiation complex (GO:0001731)3.97260609
11IMP biosynthetic process (GO:0006188)3.95341728
12protein localization to chromosome, centromeric region (GO:0071459)3.93627835
13heterochromatin organization (GO:0070828)3.93263392
14regulation of gene silencing by RNA (GO:0060966)3.92239635
15regulation of posttranscriptional gene silencing (GO:0060147)3.92239635
16regulation of gene silencing by miRNA (GO:0060964)3.92239635
17folic acid-containing compound biosynthetic process (GO:0009396)3.85093257
18mitotic metaphase plate congression (GO:0007080)3.79905797
19DNA replication initiation (GO:0006270)3.76268652
20pore complex assembly (GO:0046931)3.74930356
21regulation of nucleobase-containing compound transport (GO:0032239)3.69292175
22ribosome biogenesis (GO:0042254)3.66375177
23DNA replication checkpoint (GO:0000076)3.60830712
24purine nucleobase biosynthetic process (GO:0009113)3.56919860
25mitotic sister chromatid segregation (GO:0000070)3.54303466
26maturation of SSU-rRNA (GO:0030490)3.54117652
27regulation of spindle organization (GO:0090224)3.53232675
28ribosome assembly (GO:0042255)3.51102419
29DNA duplex unwinding (GO:0032508)3.49474779
30protein complex localization (GO:0031503)3.48381682
31DNA replication-dependent nucleosome organization (GO:0034723)3.48365202
32DNA replication-dependent nucleosome assembly (GO:0006335)3.48365202
33DNA geometric change (GO:0032392)3.47625708
34cellular protein complex localization (GO:0034629)3.45548541
35regulation of RNA export from nucleus (GO:0046831)3.45098852
36DNA strand elongation involved in DNA replication (GO:0006271)3.43135398
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43126710
38mitotic chromosome condensation (GO:0007076)3.38995548
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35158509
40histone H4-K12 acetylation (GO:0043983)3.32785248
41metaphase plate congression (GO:0051310)3.32569133
42positive regulation of chromosome segregation (GO:0051984)3.32246286
43IMP metabolic process (GO:0046040)3.32107442
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29934112
45sister chromatid segregation (GO:0000819)3.29661443
46regulation of mitotic spindle organization (GO:0060236)3.29614835
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27467205
48DNA strand elongation (GO:0022616)3.25757473
49negative regulation of histone methylation (GO:0031061)3.24539205
50regulation of chromatin binding (GO:0035561)3.24309958
51nuclear envelope organization (GO:0006998)3.23606592
52regulation of translational fidelity (GO:0006450)3.21508839
53rRNA transcription (GO:0009303)3.16518965
54mitotic sister chromatid cohesion (GO:0007064)3.15966684
55regulation of histone H3-K4 methylation (GO:0051569)3.13829474
56kinetochore organization (GO:0051383)3.13048739
57ribonucleoprotein complex biogenesis (GO:0022613)3.12887546
58regulation of translational termination (GO:0006449)3.10665833
59histone H3-K36 demethylation (GO:0070544)3.08095834
60chromosome condensation (GO:0030261)3.08033312
61glucocorticoid receptor signaling pathway (GO:0042921)3.07389006
62peptidyl-arginine omega-N-methylation (GO:0035247)3.06250782
63regulation of acrosome reaction (GO:0060046)3.05064549
64positive regulation of DNA-dependent DNA replication (GO:2000105)3.04523883
65regulation of histone H3-K9 methylation (GO:0051570)3.02104452
66regulation of NFAT protein import into nucleus (GO:0051532)3.01040035
67paraxial mesoderm development (GO:0048339)3.00664621
68negative regulation of mRNA processing (GO:0050686)3.00646307
69negative regulation of RNA splicing (GO:0033119)2.99933165
70chromatin assembly (GO:0031497)2.99464946
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.99312700
72telomere maintenance via semi-conservative replication (GO:0032201)2.97934177
73dosage compensation (GO:0007549)2.97869666
74protein localization to chromosome (GO:0034502)2.95469549
75kinetochore assembly (GO:0051382)2.95344035
76inner cell mass cell proliferation (GO:0001833)2.93159463
77regulation of histone methylation (GO:0031060)2.90987111
78mRNA transport (GO:0051028)2.89731872
79regulation of female gonad development (GO:2000194)2.89261770
80regulation of sister chromatid cohesion (GO:0007063)2.86946521
81somatic hypermutation of immunoglobulin genes (GO:0016446)2.86872007
82somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86872007
83protein kinase C signaling (GO:0070528)2.84843766
84histone H2A monoubiquitination (GO:0035518)2.84223695
85DNA topological change (GO:0006265)2.83716455
86DNA conformation change (GO:0071103)2.83181600
87histone arginine methylation (GO:0034969)2.82725566
88rRNA processing (GO:0006364)2.82483341
89trophectodermal cell differentiation (GO:0001829)2.82435484
90spliceosomal tri-snRNP complex assembly (GO:0000244)2.81117443
91negative regulation of chromosome segregation (GO:0051985)2.81109869
92establishment of chromosome localization (GO:0051303)2.81002101
93negative regulation of mRNA metabolic process (GO:1903312)2.79402392
94chromatin assembly or disassembly (GO:0006333)2.79286211
95RNA splicing, via transesterification reactions (GO:0000375)2.78596454
96regulation of chromosome segregation (GO:0051983)2.77718351
97RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.77325119
98mRNA splicing, via spliceosome (GO:0000398)2.77325119
99oocyte development (GO:0048599)2.76239844
100histone H3-K4 methylation (GO:0051568)2.76147482
101regulation of DNA methylation (GO:0044030)2.76146954
102rRNA metabolic process (GO:0016072)2.74976646
103folic acid metabolic process (GO:0046655)2.74346323
104establishment of integrated proviral latency (GO:0075713)2.73478392
105spindle checkpoint (GO:0031577)2.72440472
106positive regulation of mitotic sister chromatid separation (GO:1901970)2.71582678
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71582678
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71582678
109DNA replication-independent nucleosome organization (GO:0034724)2.70989181
110DNA replication-independent nucleosome assembly (GO:0006336)2.70989181
111telomere maintenance via recombination (GO:0000722)2.70431723
112mitotic spindle checkpoint (GO:0071174)2.70303844
113proline biosynthetic process (GO:0006561)2.70204734
114attachment of spindle microtubules to kinetochore (GO:0008608)2.69478565
115mRNA stabilization (GO:0048255)2.69447101
116RNA stabilization (GO:0043489)2.69447101
117mitotic G1 DNA damage checkpoint (GO:0031571)2.69413463
118snRNA metabolic process (GO:0016073)2.69074713
119peptidyl-arginine N-methylation (GO:0035246)2.69070046
120peptidyl-arginine methylation (GO:0018216)2.69070046
121snRNA processing (GO:0016180)2.68614093
122translational initiation (GO:0006413)2.68344934
123positive regulation of histone H3-K4 methylation (GO:0051571)2.67750841
124DNA synthesis involved in DNA repair (GO:0000731)2.67552787
125protein export from nucleus (GO:0006611)2.65694567
126mitochondrial DNA metabolic process (GO:0032042)2.64950328
127apoptotic process involved in morphogenesis (GO:0060561)2.64075341
128cell-substrate adherens junction assembly (GO:0007045)2.63094136
129focal adhesion assembly (GO:0048041)2.63094136
130negative regulation of histone modification (GO:0031057)2.62152693
131adherens junction assembly (GO:0034333)2.62144227
132stress granule assembly (GO:0034063)2.61121840
133DNA packaging (GO:0006323)2.60925728
134regulation of transcription from RNA polymerase I promoter (GO:0006356)2.59581047
1353-UTR-mediated mRNA stabilization (GO:0070935)2.59510485
136activation of Rac GTPase activity (GO:0032863)2.57294037
137transcription from mitochondrial promoter (GO:0006390)2.54738568
138ribosomal small subunit biogenesis (GO:0042274)2.54190579
139negative regulation of DNA repair (GO:0045738)2.53884354
140regulation of RNA stability (GO:0043487)2.53696013
141positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52323501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38470859
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.41479475
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.94736378
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26524848
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07354095
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.06265494
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03299172
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94720847
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55655889
10MYC_22102868_ChIP-Seq_BL_Human2.55630273
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33955612
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12927707
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10067529
14XRN2_22483619_ChIP-Seq_HELA_Human2.07005704
15* ETS1_20019798_ChIP-Seq_JURKAT_Human1.97067534
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95534197
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.94972063
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93777278
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93777278
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93777278
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93492287
22* AR_21909140_ChIP-Seq_LNCAP_Human1.92412751
23* EST1_17652178_ChIP-ChIP_JURKAT_Human1.86103727
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83126114
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81810430
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80320454
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78294496
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77352753
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.77306719
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76904143
31CIITA_25753668_ChIP-Seq_RAJI_Human1.69367653
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67016646
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66844671
34* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61155955
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56711957
36VDR_23849224_ChIP-Seq_CD4+_Human1.53744901
37KDM5A_27292631_Chip-Seq_BREAST_Human1.52280095
38GABP_19822575_ChIP-Seq_HepG2_Human1.48491617
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48397290
40* TTF2_22483619_ChIP-Seq_HELA_Human1.48250138
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46745782
42FOXP3_21729870_ChIP-Seq_TREG_Human1.46261849
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.44456133
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44038951
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43713596
46VDR_21846776_ChIP-Seq_THP-1_Human1.42638218
47* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41305751
48DCP1A_22483619_ChIP-Seq_HELA_Human1.40819735
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40416380
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39819102
51RACK7_27058665_Chip-Seq_MCF-7_Human1.38962282
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38763642
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34575742
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33478134
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31931637
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31867930
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31745654
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30453590
59* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29832067
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28065883
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27220681
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26871087
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26675242
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26470823
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25673385
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23182109
67TFEB_21752829_ChIP-Seq_HELA_Human1.22329983
68* KDM2B_26808549_Chip-Seq_DND41_Human1.20302285
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19808117
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.19653335
71LXR_22292898_ChIP-Seq_THP-1_Human1.18903891
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18131451
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17330960
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16568864
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.13378859
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12128886
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11722453
78* NOTCH1_21737748_ChIP-Seq_TLL_Human1.11308518
79* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11132411
80CHD1_26751641_Chip-Seq_LNCaP_Human1.10808465
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10534182
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10288368
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.09381328
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07670134
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06891649
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06612692
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05846450
88* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04964186
89TCF7_22412390_ChIP-Seq_EML_Mouse1.04518947
90MAF_26560356_Chip-Seq_TH1_Human1.03773825
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03197185
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02928023
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02588291
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.01904942
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01745418
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01524108
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01200719
98* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00890942
99ZNF263_19887448_ChIP-Seq_K562_Human1.00715182
100* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00310854
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00203131
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99768020
103VDR_24763502_ChIP-Seq_THP-1_Human0.99135986
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98982591
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98926432
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98727934
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98243887
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98177217
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97707054
110ELK1_19687146_ChIP-ChIP_HELA_Human0.95918690
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95416463
112MAF_26560356_Chip-Seq_TH2_Human0.95058248
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94157579
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93712187
115ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93681554
116ATF3_27146783_Chip-Seq_COLON_Human0.93093595
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92696720
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91195322
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91156046
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90996297
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90870456
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90614987
123UTX_26944678_Chip-Seq_JUKART_Human0.90198999
124NCOR1_26117541_ChIP-Seq_K562_Human0.89515169
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89380322
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88598303
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88298743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.17533702
2MP0003111_abnormal_nucleus_morphology3.87260660
3MP0004957_abnormal_blastocyst_morpholog3.69291842
4MP0008057_abnormal_DNA_replication3.65833010
5MP0010094_abnormal_chromosome_stability3.58720160
6MP0003077_abnormal_cell_cycle3.31662309
7MP0010352_gastrointestinal_tract_polyps2.96617069
8MP0001730_embryonic_growth_arrest2.46067267
9MP0008058_abnormal_DNA_repair2.35820287
10MP0005076_abnormal_cell_differentiation2.29144752
11MP0000350_abnormal_cell_proliferation2.28926154
12MP0003123_paternal_imprinting2.25455356
13MP0008007_abnormal_cellular_replicative2.22017238
14MP0002396_abnormal_hematopoietic_system2.16070703
15MP0001672_abnormal_embryogenesis/_devel2.10989063
16MP0005380_embryogenesis_phenotype2.10989063
17MP0005451_abnormal_body_composition2.06462828
18MP0008932_abnormal_embryonic_tissue2.03711636
19MP0010307_abnormal_tumor_latency2.02408151
20MP0003984_embryonic_growth_retardation1.96718443
21MP0003705_abnormal_hypodermis_morpholog1.96227239
22MP0002088_abnormal_embryonic_growth/wei1.93729516
23MP0010030_abnormal_orbit_morphology1.90107221
24MP0004197_abnormal_fetal_growth/weight/1.88520163
25MP0002084_abnormal_developmental_patter1.85893599
26MP0001697_abnormal_embryo_size1.85459255
27MP0002085_abnormal_embryonic_tissue1.82888391
28MP0002086_abnormal_extraembryonic_tissu1.81209286
29MP0008877_abnormal_DNA_methylation1.79550094
30MP0002796_impaired_skin_barrier1.72492668
31MP0003786_premature_aging1.71153458
32MP0002080_prenatal_lethality1.66232800
33MP0003567_abnormal_fetal_cardiomyocyte1.61914778
34MP0009278_abnormal_bone_marrow1.61500524
35MP0004808_abnormal_hematopoietic_stem1.59085719
36MP0000490_abnormal_crypts_of1.52386531
37MP0002877_abnormal_melanocyte_morpholog1.48972704
38MP0001293_anophthalmia1.39729246
39MP0003890_abnormal_embryonic-extraembry1.37601054
40MP0002089_abnormal_postnatal_growth/wei1.35335331
41MP0003453_abnormal_keratinocyte_physiol1.35092314
42MP0005397_hematopoietic_system_phenotyp1.34392244
43MP0001545_abnormal_hematopoietic_system1.34392244
44MP0010234_abnormal_vibrissa_follicle1.31739488
45MP0003566_abnormal_cell_adhesion1.30752720
46MP0003119_abnormal_digestive_system1.30574792
47MP0000313_abnormal_cell_death1.29196353
48MP0003121_genomic_imprinting1.28937125
49MP0002653_abnormal_ependyma_morphology1.24815484
50MP0002254_reproductive_system_inflammat1.22614216
51MP0009333_abnormal_splenocyte_physiolog1.21249964
52MP0009672_abnormal_birth_weight1.20234593
53MP0009053_abnormal_anal_canal1.19928884
54MP0003091_abnormal_cell_migration1.19880671
55MP0002019_abnormal_tumor_incidence1.18985030
56MP0002060_abnormal_skin_morphology1.18704701
57MP0003941_abnormal_skin_development1.17738074
58MP0005023_abnormal_wound_healing1.16335970
59MP0003699_abnormal_female_reproductive1.11167679
60MP0001849_ear_inflammation1.10817019
61MP0001346_abnormal_lacrimal_gland1.07836275
62MP0000733_abnormal_muscle_development1.07565265
63MP0001348_abnormal_lacrimal_gland1.06813138
64MP0001915_intracranial_hemorrhage1.05234262
65MP0000428_abnormal_craniofacial_morphol1.02863175
66MP0009703_decreased_birth_body1.02513982
67MP0000703_abnormal_thymus_morphology1.02087842
68MP0000678_abnormal_parathyroid_gland1.01579331
69MP0002111_abnormal_tail_morphology1.00413796
70MP0000537_abnormal_urethra_morphology0.98953157
71MP0002210_abnormal_sex_determination0.96085888
72MP0000762_abnormal_tongue_morphology0.94200134
73MP0002092_abnormal_eye_morphology0.94194866
74MP0008438_abnormal_cutaneous_collagen0.93861190
75MP0003718_maternal_effect0.93737849
76MP0004264_abnormal_extraembryonic_tissu0.93469474
77MP0003763_abnormal_thymus_physiology0.91927798
78MP0000003_abnormal_adipose_tissue0.91725535
79MP0000432_abnormal_head_morphology0.90197638
80MP0002925_abnormal_cardiovascular_devel0.90186506
81MP0001216_abnormal_epidermal_layer0.89206231
82MP0000579_abnormal_nail_morphology0.89003589
83MP0001145_abnormal_male_reproductive0.87764747
84MP0003935_abnormal_craniofacial_develop0.87058222
85MP0002697_abnormal_eye_size0.86414919
86MP0005621_abnormal_cell_physiology0.86092202
87MP0003115_abnormal_respiratory_system0.85742668
88MP0005395_other_phenotype0.85727431
89MP0003937_abnormal_limbs/digits/tail_de0.85518645
90MP0001661_extended_life_span0.84815117
91MP0002398_abnormal_bone_marrow0.83387219
92MP0009840_abnormal_foam_cell0.82609083
93MP0002722_abnormal_immune_system0.82213861
94MP0001873_stomach_inflammation0.80102820
95MP0000750_abnormal_muscle_regeneration0.79314942
96MP0003315_abnormal_perineum_morphology0.77967016
97MP0005384_cellular_phenotype0.77844958
98MP0000566_synostosis0.76950559
99MP0000689_abnormal_spleen_morphology0.76525602
100MP0004133_heterotaxia0.75392527
101MP0002098_abnormal_vibrissa_morphology0.74436053
102MP0005257_abnormal_intraocular_pressure0.74306967
103MP0000858_altered_metastatic_potential0.74202993
104MP0008995_early_reproductive_senescence0.72915441
105MP0009931_abnormal_skin_appearance0.72509638
106MP0005666_abnormal_adipose_tissue0.71587216
107MP0005409_darkened_coat_color0.70787963
108MP0005375_adipose_tissue_phenotype0.70337872
109MP0006292_abnormal_olfactory_placode0.70162535
110MP0002006_tumorigenesis0.70085374
111MP0008770_decreased_survivor_rate0.69777141
112MP0000477_abnormal_intestine_morphology0.69571300
113MP0001286_abnormal_eye_development0.69232401
114MP0004233_abnormal_muscle_weight0.68751007
115MP0000653_abnormal_sex_gland0.67994069
116MP0003755_abnormal_palate_morphology0.67912275
117MP0000266_abnormal_heart_morphology0.67896796
118MP0002166_altered_tumor_susceptibility0.67789709
119MP0003943_abnormal_hepatobiliary_system0.67546007
120MP0003283_abnormal_digestive_organ0.67476004
121MP0002932_abnormal_joint_morphology0.67142676
122MP0005623_abnormal_meninges_morphology0.66602513
123MP0000358_abnormal_cell_content/0.66218041
124MP0008260_abnormal_autophagy0.65282814
125MP0004947_skin_inflammation0.64649661
126MP0004185_abnormal_adipocyte_glucose0.63277662
127MP0003936_abnormal_reproductive_system0.63212503
128MP0003448_altered_tumor_morphology0.62372160
129MP0002114_abnormal_axial_skeleton0.62245536
130MP0002249_abnormal_larynx_morphology0.61933313
131MP0001929_abnormal_gametogenesis0.60968324
132MP0002429_abnormal_blood_cell0.58643727
133MP0010630_abnormal_cardiac_muscle0.57324002
134MP0000627_abnormal_mammary_gland0.57304140
135MP0003221_abnormal_cardiomyocyte_apopto0.57076741
136MP0005501_abnormal_skin_physiology0.56925737

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.65405313
2Selective tooth agenesis (HP:0001592)3.63880109
3Progressive muscle weakness (HP:0003323)3.46699946
4Chromsome breakage (HP:0040012)3.11175319
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04914130
6Birth length less than 3rd percentile (HP:0003561)2.94615294
7Medulloblastoma (HP:0002885)2.83063393
8Deviation of the thumb (HP:0009603)2.70548915
9Proximal placement of thumb (HP:0009623)2.70115401
10Abnormality of the astrocytes (HP:0100707)2.69118135
11Astrocytoma (HP:0009592)2.69118135
12Breast hypoplasia (HP:0003187)2.68479788
13Patellar aplasia (HP:0006443)2.67489807
14Multiple enchondromatosis (HP:0005701)2.63604309
15Absent radius (HP:0003974)2.61494171
16Dysmetric saccades (HP:0000641)2.58860894
17Impulsivity (HP:0100710)2.58520372
18Rib fusion (HP:0000902)2.53355860
19Aplasia/Hypoplasia of the patella (HP:0006498)2.52262549
20Microvesicular hepatic steatosis (HP:0001414)2.52235587
21Reticulocytopenia (HP:0001896)2.51465529
22Degeneration of anterior horn cells (HP:0002398)2.48781146
23Abnormality of the anterior horn cell (HP:0006802)2.48781146
24Progressive external ophthalmoplegia (HP:0000590)2.47694866
25Lip pit (HP:0100267)2.47422526
26Carpal bone hypoplasia (HP:0001498)2.47399162
27Aplasia/hypoplasia of the humerus (HP:0006507)2.45843427
28Long palpebral fissure (HP:0000637)2.43993761
29Hypergonadotropic hypogonadism (HP:0000815)2.43675972
30Ectopic kidney (HP:0000086)2.42178333
31Absent forearm bone (HP:0003953)2.40961587
32Aplasia involving forearm bones (HP:0009822)2.40961587
33Colon cancer (HP:0003003)2.39427136
34Abnormal number of incisors (HP:0011064)2.39038943
35Abnormality of the labia minora (HP:0012880)2.36944419
36Missing ribs (HP:0000921)2.36762304
37Long eyelashes (HP:0000527)2.36061653
38Rhabdomyosarcoma (HP:0002859)2.36043034
39Neoplasm of the oral cavity (HP:0100649)2.35289858
40Short humerus (HP:0005792)2.34561677
41Increased nuchal translucency (HP:0010880)2.34338325
42Facial hemangioma (HP:0000329)2.33324859
43Meckel diverticulum (HP:0002245)2.33155569
44Prominent nose (HP:0000448)2.32705676
45Septate vagina (HP:0001153)2.30699449
46Glioma (HP:0009733)2.28126596
47Abnormality of the ileum (HP:0001549)2.25714667
48Basal cell carcinoma (HP:0002671)2.23816175
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21145396
50Short 4th metacarpal (HP:0010044)2.21145396
51Abnormality of the salivary glands (HP:0010286)2.21008372
52Neoplasm of striated muscle (HP:0009728)2.20072571
53Abnormality of the fingertips (HP:0001211)2.19178686
54Abnormality of chromosome stability (HP:0003220)2.19004948
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.15413658
56Absent thumb (HP:0009777)2.13554243
57Trismus (HP:0000211)2.12663362
58Rough bone trabeculation (HP:0100670)2.12611288
59Disproportionate tall stature (HP:0001519)2.12464353
60Sparse lateral eyebrow (HP:0005338)2.10239897
61Myelodysplasia (HP:0002863)2.09490474
62Secondary amenorrhea (HP:0000869)2.07678898
63Anal stenosis (HP:0002025)2.07438202
64Abnormality of the phalanges of the hallux (HP:0010057)2.07122166
65Natal tooth (HP:0000695)2.05846749
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.02637980
67Deep philtrum (HP:0002002)2.01659851
68Atresia of the external auditory canal (HP:0000413)2.01367669
69Advanced eruption of teeth (HP:0006288)2.01299605
70Premature rupture of membranes (HP:0001788)2.00885013
71Broad face (HP:0000283)2.00178571
72Acute lymphatic leukemia (HP:0006721)1.98887648
73Urethral obstruction (HP:0000796)1.98646061
7411 pairs of ribs (HP:0000878)1.97157273
75Protrusio acetabuli (HP:0003179)1.95149814
76Abnormality of the preputium (HP:0100587)1.95096511
77Skin tags (HP:0010609)1.94972078
78Oral leukoplakia (HP:0002745)1.93901682
79Broad thumb (HP:0011304)1.93400924
80Broad palm (HP:0001169)1.93233833
81Supernumerary spleens (HP:0009799)1.92731423
82Distal lower limb amyotrophy (HP:0008944)1.91912423
83Ankle contracture (HP:0006466)1.91310727
84Spinal muscular atrophy (HP:0007269)1.91056984
85Neoplasm of the pancreas (HP:0002894)1.90815384
86Abnormality of the thoracic spine (HP:0100711)1.90286086
87Metaphyseal cupping (HP:0003021)1.90282241
88Shawl scrotum (HP:0000049)1.90153513
89Preauricular skin tag (HP:0000384)1.89968680
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89921278
91Renal duplication (HP:0000075)1.89671237
92Intestinal fistula (HP:0100819)1.89428805
93Agnosia (HP:0010524)1.89300062
94Increased connective tissue (HP:0009025)1.89230143
95Duodenal stenosis (HP:0100867)1.88755773
96Small intestinal stenosis (HP:0012848)1.88755773
97High anterior hairline (HP:0009890)1.88638376
98Supernumerary bones of the axial skeleton (HP:0009144)1.87231186
99Nephroblastoma (Wilms tumor) (HP:0002667)1.87127592
100Flat acetabular roof (HP:0003180)1.87063695
101Cafe-au-lait spot (HP:0000957)1.86746539
102Genu recurvatum (HP:0002816)1.86382185
103Tracheoesophageal fistula (HP:0002575)1.85910803
104Supernumerary ribs (HP:0005815)1.85470978
105Skull defect (HP:0001362)1.85318333
106Pseudobulbar signs (HP:0002200)1.84191166
107Ureteral duplication (HP:0000073)1.83991917
108Premature skin wrinkling (HP:0100678)1.83216851
109Short thumb (HP:0009778)1.83118928
110Duplication of thumb phalanx (HP:0009942)1.83058888
111Volvulus (HP:0002580)1.82851244
112Poikiloderma (HP:0001029)1.82169650
113High pitched voice (HP:0001620)1.81825546
114Progressive hearing impairment (HP:0001730)1.81777592
115Short 5th finger (HP:0009237)1.81468356
116Ragged-red muscle fibers (HP:0003200)1.81433872
117Nasolacrimal duct obstruction (HP:0000579)1.81108634
118Abnormality of the calcaneus (HP:0008364)1.80877600
119Malignant gastrointestinal tract tumors (HP:0006749)1.80588951
120Gastrointestinal carcinoma (HP:0002672)1.80588951
121Ankyloglossia (HP:0010296)1.80520450
122Insomnia (HP:0100785)1.80112986
123Abnormality of cells of the erythroid lineage (HP:0012130)1.79535897
124Premature ovarian failure (HP:0008209)1.78575948
125Hyperacusis (HP:0010780)1.78476006
126Capillary hemangiomas (HP:0005306)1.78254474
127Persistence of primary teeth (HP:0006335)1.77692191
128Dislocated radial head (HP:0003083)1.76872529
129Abnormality of the columella (HP:0009929)1.76141159
130Self-mutilation (HP:0000742)1.76060953
131Squamous cell carcinoma (HP:0002860)1.75445795
132Overlapping toe (HP:0001845)1.74514028
133Heterotopia (HP:0002282)1.73994022
134Achilles tendon contracture (HP:0001771)1.72674918
135Shallow orbits (HP:0000586)1.71053449
136Distal upper limb amyotrophy (HP:0007149)1.70776463
137Upper limb amyotrophy (HP:0009129)1.70776463
138Broad phalanges of the hand (HP:0009768)1.70443012
139Abnormality of abdominal situs (HP:0011620)1.70425874
140Abdominal situs inversus (HP:0003363)1.70425874
141Deep palmar crease (HP:0006191)1.69879704
142Elbow flexion contracture (HP:0002987)1.68576570
143Ulnar bowing (HP:0003031)1.68490936
144Embryonal renal neoplasm (HP:0011794)1.67985737
145Vertebral fusion (HP:0002948)1.67795791
146Obstructive sleep apnea (HP:0002870)1.67681801
147Abnormal number of erythroid precursors (HP:0012131)1.66441115
148Pelvic girdle muscle weakness (HP:0003749)1.65842566
149Abnormality of the duodenum (HP:0002246)1.65773752
150Choanal atresia (HP:0000453)1.65740764
151Abnormality of the carotid arteries (HP:0005344)1.65536889
152Centrally nucleated skeletal muscle fibers (HP:0003687)1.63601468
153Homocystinuria (HP:0002156)1.62388112
154Abnormality of homocysteine metabolism (HP:0010919)1.62388112
155Glossoptosis (HP:0000162)1.62051586
156Renal cell carcinoma (HP:0005584)1.59818432
157Uterine leiomyosarcoma (HP:0002891)1.59220483
158Leiomyosarcoma (HP:0100243)1.59220483
159Broad distal phalanx of finger (HP:0009836)1.57790733
160Entropion (HP:0000621)1.57753705
161Abnormality of the radial head (HP:0003995)1.56217401
162Abnormality of the distal phalanges of the toes (HP:0010182)1.56139908
163Abnormality of oral frenula (HP:0000190)1.55410200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.14489152
2SMG13.80257614
3CDC73.75036544
4BUB13.01492108
5WEE12.96193492
6NEK22.82921061
7EEF2K2.56571785
8PRPF4B2.21670367
9TSSK62.13309270
10CDK72.12635896
11BRD42.12262516
12TTK2.11331729
13MAP3K102.10469677
14EPHA22.09414099
15IRAK31.90298317
16CDK41.84126013
17RPS6KB21.78453303
18SRPK11.73105797
19PLK11.72236076
20SIK11.71559089
21MKNK11.63628675
22STK101.62599455
23PKN21.58368270
24ATR1.57089939
25CAMK1G1.51858471
26ACVR1B1.48122054
27LATS11.46341984
28ALK1.45667388
29CHEK11.44614506
30MKNK21.44129593
31NEK11.43927018
32EIF2AK11.43604889
33MTOR1.40056977
34MAP3K131.36912862
35AURKB1.36322445
36TRIB31.34379727
37RPS6KA41.34115971
38LATS21.31810511
39CHEK21.30945835
40MAP3K81.29107659
41PASK1.27680019
42ICK1.27548285
43PLK41.23661300
44MAP4K11.21763126
45PAK41.21714868
46STK31.19861171
47MST1R1.19458023
48BRSK21.17692731
49PBK1.11798571
50VRK21.11570127
51NME21.10950678
52FGFR41.09918201
53PIM11.07851794
54CDK21.07424423
55DYRK31.06427393
56CDK61.06175312
57PLK31.04443791
58MAP3K91.04052286
59TESK21.00952227
60ATM1.00748193
61NME10.95918377
62MET0.95315065
63TGFBR10.94418337
64PAK20.93125171
65TTN0.90281091
66MAPK110.89008194
67MAP3K140.88347606
68CDK80.88284925
69PTK20.87940644
70AURKA0.86151556
71STK40.85567924
72ARAF0.83539290
73MAP2K30.82648447
74BRAF0.81280570
75SCYL20.79004000
76AKT30.77601570
77CLK10.76307224
78RIPK10.74336731
79RAF10.72149725
80CDK10.71229212
81TAOK10.70489148
82CHUK0.68707988
83MAP3K110.66991453
84BMX0.66718840
85TAF10.65188511
86LRRK20.64711644
87CDC42BPA0.64524189
88CAMK1D0.64262470
89FGFR10.63943657
90PIM20.63721944
91FLT30.63257957
92STK38L0.62426503
93AKT20.61313080
94PDGFRA0.60105027
95ERN10.59301972
96CSNK2A20.58911493
97PAK10.58448124
98MELK0.58111827
99JAK30.56664061
100CSNK1E0.56539558
101BRSK10.56393106
102PTK60.53418813
103PRKD20.50307342
104GRK60.49662542
105MAP3K30.48878916
106MAPK10.48123966
107DDR20.48050437
108MAPK140.47749840
109PNCK0.47095010
110TLK10.47038080
111CDK90.46094030
112TAOK20.45967056
113PRKDC0.45963419
114NEK60.45808740
115PRKCI0.44230477
116ZAP700.44087177
117CSNK1D0.43047219
118ERBB40.42206491
119TYRO30.41384380
120CSNK2A10.40609993
121PRKD30.39725512
122MAPKAPK30.36927439
123AKT10.36657375
124RPS6KA10.35492284
125GSK3B0.35045761
126MARK20.34040953
127DMPK0.33155101
128RPS6KL10.32951754
129RPS6KC10.32951754
130EIF2AK20.32722278
131KSR20.32160740
132VRK10.32144021
133MARK30.29981581
134EIF2AK30.29740351

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.00367288
2DNA replication_Homo sapiens_hsa030303.85684539
3RNA transport_Homo sapiens_hsa030133.39035118
4Mismatch repair_Homo sapiens_hsa034303.34010295
5Spliceosome_Homo sapiens_hsa030403.12782161
6One carbon pool by folate_Homo sapiens_hsa006702.81574854
7Base excision repair_Homo sapiens_hsa034102.76588257
8Cell cycle_Homo sapiens_hsa041102.69073702
9RNA polymerase_Homo sapiens_hsa030202.60205961
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47264053
11Homologous recombination_Homo sapiens_hsa034402.34184691
12mRNA surveillance pathway_Homo sapiens_hsa030152.20643495
13Nucleotide excision repair_Homo sapiens_hsa034202.18871902
14Ribosome_Homo sapiens_hsa030102.03476251
15Fanconi anemia pathway_Homo sapiens_hsa034602.00477075
16p53 signaling pathway_Homo sapiens_hsa041151.78276522
17Pyrimidine metabolism_Homo sapiens_hsa002401.70165134
18RNA degradation_Homo sapiens_hsa030181.69833229
19Non-homologous end-joining_Homo sapiens_hsa034501.57478664
20Basal transcription factors_Homo sapiens_hsa030221.53608297
21MicroRNAs in cancer_Homo sapiens_hsa052061.26515139
22Epstein-Barr virus infection_Homo sapiens_hsa051691.25132434
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24797951
24Herpes simplex infection_Homo sapiens_hsa051681.21423382
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20376237
26Viral carcinogenesis_Homo sapiens_hsa052031.16658745
27Proteasome_Homo sapiens_hsa030501.16261518
28Notch signaling pathway_Homo sapiens_hsa043301.15000568
29Small cell lung cancer_Homo sapiens_hsa052221.14834116
30HTLV-I infection_Homo sapiens_hsa051661.13183113
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11692216
32Basal cell carcinoma_Homo sapiens_hsa052171.05284018
33Hippo signaling pathway_Homo sapiens_hsa043901.00825161
34Chronic myeloid leukemia_Homo sapiens_hsa052200.99634192
35Thyroid cancer_Homo sapiens_hsa052160.98835014
36Antigen processing and presentation_Homo sapiens_hsa046120.98745499
37Lysine degradation_Homo sapiens_hsa003100.96501381
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93779180
39Vitamin B6 metabolism_Homo sapiens_hsa007500.92297905
40mTOR signaling pathway_Homo sapiens_hsa041500.88600284
41Adherens junction_Homo sapiens_hsa045200.88316329
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87914157
43Selenocompound metabolism_Homo sapiens_hsa004500.87216573
44TGF-beta signaling pathway_Homo sapiens_hsa043500.86603002
45Oocyte meiosis_Homo sapiens_hsa041140.84920293
46Acute myeloid leukemia_Homo sapiens_hsa052210.82268768
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82039566
48Biosynthesis of amino acids_Homo sapiens_hsa012300.80699470
49Renal cell carcinoma_Homo sapiens_hsa052110.79090954
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.77715301
51Colorectal cancer_Homo sapiens_hsa052100.77004184
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75763801
53Purine metabolism_Homo sapiens_hsa002300.74508187
54Bladder cancer_Homo sapiens_hsa052190.74464205
55Hedgehog signaling pathway_Homo sapiens_hsa043400.73327955
56ErbB signaling pathway_Homo sapiens_hsa040120.73186266
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.72794951
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.71182880
59Apoptosis_Homo sapiens_hsa042100.71003318
60Fructose and mannose metabolism_Homo sapiens_hsa000510.70893434
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69497141
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.67569226
63Hepatitis B_Homo sapiens_hsa051610.67218858
64Viral myocarditis_Homo sapiens_hsa054160.66303996
65Legionellosis_Homo sapiens_hsa051340.65316482
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64273688
67VEGF signaling pathway_Homo sapiens_hsa043700.63551190
68Insulin signaling pathway_Homo sapiens_hsa049100.62592168
69Pentose phosphate pathway_Homo sapiens_hsa000300.62153663
70Proteoglycans in cancer_Homo sapiens_hsa052050.61821849
71TNF signaling pathway_Homo sapiens_hsa046680.61277220
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61265748
73Prostate cancer_Homo sapiens_hsa052150.60351483
74Pathways in cancer_Homo sapiens_hsa052000.60303310
75Glioma_Homo sapiens_hsa052140.59652874
76Measles_Homo sapiens_hsa051620.58207164
77HIF-1 signaling pathway_Homo sapiens_hsa040660.58099476
78Inositol phosphate metabolism_Homo sapiens_hsa005620.57647656
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57376193
80Hepatitis C_Homo sapiens_hsa051600.56465663
81N-Glycan biosynthesis_Homo sapiens_hsa005100.55716433
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54894475
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54761371
84Primary immunodeficiency_Homo sapiens_hsa053400.54397366
85Shigellosis_Homo sapiens_hsa051310.50772601
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49883627
87AMPK signaling pathway_Homo sapiens_hsa041520.49636212
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49212075
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48849897
90Folate biosynthesis_Homo sapiens_hsa007900.48120887
91Influenza A_Homo sapiens_hsa051640.47781255
92Wnt signaling pathway_Homo sapiens_hsa043100.47402730
93Non-small cell lung cancer_Homo sapiens_hsa052230.46428232
94Pancreatic cancer_Homo sapiens_hsa052120.46146763
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45002145
96Sulfur relay system_Homo sapiens_hsa041220.44929998
97Endometrial cancer_Homo sapiens_hsa052130.44567655
98Carbon metabolism_Homo sapiens_hsa012000.44037739
99Prion diseases_Homo sapiens_hsa050200.43203322
100Systemic lupus erythematosus_Homo sapiens_hsa053220.43087975
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42124431
102B cell receptor signaling pathway_Homo sapiens_hsa046620.41880973
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41727977
104Focal adhesion_Homo sapiens_hsa045100.40208214
105T cell receptor signaling pathway_Homo sapiens_hsa046600.39522065
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38881015
107ECM-receptor interaction_Homo sapiens_hsa045120.37964380
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37553084
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37433755
110Tight junction_Homo sapiens_hsa045300.37076617
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.36636817
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.35079566
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35004836
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.34935219
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34443625
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33998841
117Toxoplasmosis_Homo sapiens_hsa051450.33046658
118FoxO signaling pathway_Homo sapiens_hsa040680.32191930
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.31023552
120Hematopoietic cell lineage_Homo sapiens_hsa046400.28097464
121Melanoma_Homo sapiens_hsa052180.26968898

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