ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.12888831
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.99233406
3	ATP synthesis coupled proton transport (GO:0015986)	5.99233406
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.39977988
5	protein neddylation (GO:0045116)	5.25084485
6	viral transcription (GO:0019083)	5.05963075
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.99455957
8	respiratory electron transport chain (GO:0022904)	4.89769500
9	translational termination (GO:0006415)	4.89385685
10	electron transport chain (GO:0022900)	4.83885428
11	DNA damage response, detection of DNA damage (GO:0042769)	4.71299582
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.56372110
13	NADH dehydrogenase complex assembly (GO:0010257)	4.56372110
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.56372110
15	negative regulation of telomere maintenance (GO:0032205)	4.48648414
16	chaperone-mediated protein transport (GO:0072321)	4.48512734
17	protein complex biogenesis (GO:0070271)	4.47777537
18	mitochondrial respiratory chain complex assembly (GO:0033108)	4.33842162
19	cotranslational protein targeting to membrane (GO:0006613)	4.15578853
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.12915349
21	protein targeting to ER (GO:0045047)	4.08568792
22	translational elongation (GO:0006414)	4.07943627
23	ribosomal small subunit biogenesis (GO:0042274)	4.01909475
24	negative regulation of telomerase activity (GO:0051974)	3.97313048
25	maturation of SSU-rRNA (GO:0030490)	3.96271204
26	ventricular trabecula myocardium morphogenesis (GO:0003222)	3.95920089
27	proteasome assembly (GO:0043248)	3.93074171
28	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.91749201
29	ribosomal small subunit assembly (GO:0000028)	3.91253439
30	sequestering of actin monomers (GO:0042989)	3.85639200
31	protein localization to endoplasmic reticulum (GO:0070972)	3.77605312
32	cellular protein complex disassembly (GO:0043624)	3.76703453
33	CENP-A containing nucleosome assembly (GO:0034080)	3.76256060
34	viral life cycle (GO:0019058)	3.73983498
35	chromatin remodeling at centromere (GO:0031055)	3.71592883
36	DNA replication checkpoint (GO:0000076)	3.70280519
37	DNA damage induced protein phosphorylation (GO:0006975)	3.62873500
38	positive regulation of cellular response to oxidative stress (GO:1900409)	3.56514189
39	positive regulation of response to oxidative stress (GO:1902884)	3.56514189
40	regulation of helicase activity (GO:0051095)	3.53597199
41	heart trabecula morphogenesis (GO:0061384)	3.51203800
42	regulation of mitochondrial translation (GO:0070129)	3.51147164
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.44326748
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.39525914
45	termination of RNA polymerase III transcription (GO:0006386)	3.39525914
46	ATP biosynthetic process (GO:0006754)	3.33527376
47	cardiac right ventricle morphogenesis (GO:0003215)	3.32938482
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.29912011
49	translational initiation (GO:0006413)	3.29609338
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.28849564
51	protein-cofactor linkage (GO:0018065)	3.26054037
52	protein complex disassembly (GO:0043241)	3.22278555
53	regulation of oxidative phosphorylation (GO:0002082)	3.19451985
54	telomere maintenance via telomerase (GO:0007004)	3.16053990
55	GTP biosynthetic process (GO:0006183)	3.14036492
56	histone exchange (GO:0043486)	3.13106221
57	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.07706635
58	water-soluble vitamin biosynthetic process (GO:0042364)	3.04102251
59	macromolecular complex disassembly (GO:0032984)	2.99472588
60	spliceosomal snRNP assembly (GO:0000387)	2.97909343
61	ribosomal large subunit biogenesis (GO:0042273)	2.94990899
62	translation (GO:0006412)	2.90599018
63	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.89064724
64	regulation of telomere maintenance via telomerase (GO:0032210)	2.88824920
65	hydrogen ion transmembrane transport (GO:1902600)	2.86463607
66	inner mitochondrial membrane organization (GO:0007007)	2.83830861
67	kinetochore assembly (GO:0051382)	2.80613143
68	UTP biosynthetic process (GO:0006228)	2.79351258
69	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.76343143
70	otic vesicle formation (GO:0030916)	2.74879578
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.74361110
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.72244993
73	kinetochore organization (GO:0051383)	2.70189143
74	intra-S DNA damage checkpoint (GO:0031573)	2.66906217
75	regulation of telomerase activity (GO:0051972)	2.65680654
76	UTP metabolic process (GO:0046051)	2.65566711
77	protein targeting to mitochondrion (GO:0006626)	2.65193448
78	behavioral response to nicotine (GO:0035095)	2.63563294
79	rRNA modification (GO:0000154)	2.63186217
80	DNA replication-independent nucleosome organization (GO:0034724)	2.62652068
81	DNA replication-independent nucleosome assembly (GO:0006336)	2.62652068
82	proton transport (GO:0015992)	2.61696866
83	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.61529627
84	nucleoside triphosphate biosynthetic process (GO:0009142)	2.61225201
85	mitochondrial transport (GO:0006839)	2.60899022
86	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.59724227
87	hydrogen transport (GO:0006818)	2.58431125
88	midbrain development (GO:0030901)	2.56934887
89	protein targeting to membrane (GO:0006612)	2.56704754
90	ventricular cardiac muscle cell development (GO:0055015)	2.56001504
91	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.53056721
92	protein localization to mitochondrion (GO:0070585)	2.52958258
93	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.52485808
94	establishment of protein localization to mitochondrion (GO:0072655)	2.52163634
95	negative regulation of DNA biosynthetic process (GO:2000279)	2.51971902
96	pseudouridine synthesis (GO:0001522)	2.50709854
97	platelet dense granule organization (GO:0060155)	2.49443728
98	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.47599299
99	purine nucleobase biosynthetic process (GO:0009113)	2.46086119
100	cellular component biogenesis (GO:0044085)	2.45466024

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.42475506
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.00641105
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.39916238
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.14081973
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.86702011
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.85126649
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.75229471
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.71137618
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.67575136
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.53752481
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53125796
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.51386568
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.47080539
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41848982
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40932944
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.38358135
17	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.36722490
18	EWS_26573619_Chip-Seq_HEK293_Human	2.27894128
19	MYC_18940864_ChIP-ChIP_HL60_Human	2.27807252
20	EZH2_22144423_ChIP-Seq_EOC_Human	2.25318098
21	VDR_22108803_ChIP-Seq_LS180_Human	2.15692415
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.08118927
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.03896502
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.02073453
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.99131344
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96194156
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.94679541
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.93764133
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.88594058
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.87270752
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83872750
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.79823533
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.76231361
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.76199370
35	FUS_26573619_Chip-Seq_HEK293_Human	1.73644715
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.70888335
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.66888058
38	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.66777183
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66035900
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64337626
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62070270
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.61197304
43	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.54530464
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43459981
45	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.42523033
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41907984
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.39433055
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.39244483
49	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.37558503
50	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34757285
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33243342
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.29952204
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29026229
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28377074
55	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28223033
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22873887
57	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.20978552
58	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.20812187
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20270631
60	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.17717103
61	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17016697
62	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16103359
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15864273
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11477859
65	ZNF274_21170338_ChIP-Seq_K562_Hela	1.09058808
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08845971
67	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08827706
68	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07001593
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06458055
70	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.04847905
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.04810362
72	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.04769998
73	GBX2_23144817_ChIP-Seq_PC3_Human	1.03668383
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99366806
75	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99360080
76	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96230729
77	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96197083
78	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94382625
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93055137
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93038403
81	P300_19829295_ChIP-Seq_ESCs_Human	0.93025952
82	GABP_19822575_ChIP-Seq_HepG2_Human	0.92618298
83	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.91914479
84	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.87418753
85	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86586981
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.86535683
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.85952556
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85555911
89	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.85381023
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.83453870
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83266508
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82491064
93	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.82322436
94	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.81784401
95	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.81725325
96	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.80336774
97	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.80029178
98	KDM5A_27292631_Chip-Seq_BREAST_Human	0.79520432
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.78346598
100	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.77997884

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.51969452
2	MP0003136_yellow_coat_color	3.40433000
3	MP0006292_abnormal_olfactory_placode	3.15043188
4	MP0002938_white_spotting	2.62779931
5	MP0003283_abnormal_digestive_organ	2.60893656
6	MP0004133_heterotaxia	2.32650919
7	MP0003195_calcinosis	2.30162346
8	MP0001529_abnormal_vocalization	2.16128918
9	MP0008995_early_reproductive_senescence	2.10081024
10	MP0005646_abnormal_pituitary_gland	2.07442277
11	MP0002736_abnormal_nociception_after	2.06124399
12	MP0000631_abnormal_neuroendocrine_gland	1.99413446
13	MP0008058_abnormal_DNA_repair	1.98281679
14	MP0000372_irregular_coat_pigmentation	1.73740837
15	MP0010094_abnormal_chromosome_stability	1.72418846
16	MP0000049_abnormal_middle_ear	1.72144348
17	MP0005084_abnormal_gallbladder_morpholo	1.71668016
18	MP0001293_anophthalmia	1.71624278
19	MP0000566_synostosis	1.71128572
20	MP0010030_abnormal_orbit_morphology	1.70186690
21	MP0003880_abnormal_central_pattern	1.68788095
22	MP0003693_abnormal_embryo_hatching	1.67388252
23	MP0003890_abnormal_embryonic-extraembry	1.64218219
24	MP0003315_abnormal_perineum_morphology	1.63895111
25	MP0003119_abnormal_digestive_system	1.61996924
26	MP0001968_abnormal_touch/_nociception	1.61879415
27	MP0004147_increased_porphyrin_level	1.57191457
28	MP0002277_abnormal_respiratory_mucosa	1.56724980
29	MP0006072_abnormal_retinal_apoptosis	1.49512130
30	MP0003937_abnormal_limbs/digits/tail_de	1.48791745
31	MP0003938_abnormal_ear_development	1.48467285
32	MP0000537_abnormal_urethra_morphology	1.47891397
33	MP0003718_maternal_effect	1.45249844
34	MP0009250_abnormal_appendicular_skeleto	1.44248792
35	MP0001879_abnormal_lymphatic_vessel	1.43670881
36	MP0009697_abnormal_copulation	1.42283763
37	MP0005187_abnormal_penis_morphology	1.40706669
38	MP0006036_abnormal_mitochondrial_physio	1.39593454
39	MP0003011_delayed_dark_adaptation	1.38244217
40	MP0003186_abnormal_redox_activity	1.36071605
41	MP0003077_abnormal_cell_cycle	1.34801870
42	MP0001485_abnormal_pinna_reflex	1.32189394
43	MP0003111_abnormal_nucleus_morphology	1.30508511
44	MP0002102_abnormal_ear_morphology	1.28369950
45	MP0005171_absent_coat_pigmentation	1.26782581
46	MP0003942_abnormal_urinary_system	1.26517432
47	MP0001286_abnormal_eye_development	1.25280385
48	MP0002249_abnormal_larynx_morphology	1.23136815
49	MP0004142_abnormal_muscle_tone	1.21817420
50	MP0002822_catalepsy	1.21126066
51	MP0004742_abnormal_vestibular_system	1.20624999
52	MP0002697_abnormal_eye_size	1.19195020
53	MP0009384_cardiac_valve_regurgitation	1.16179101
54	MP0006276_abnormal_autonomic_nervous	1.15526072
55	MP0008932_abnormal_embryonic_tissue	1.15194205
56	MP0002837_dystrophic_cardiac_calcinosis	1.14466643
57	MP0008007_abnormal_cellular_replicative	1.12050422
58	MP0004885_abnormal_endolymph	1.08947744
59	MP0003567_abnormal_fetal_cardiomyocyte	1.07486657
60	MP0000026_abnormal_inner_ear	1.07319639
61	MP0002127_abnormal_cardiovascular_syste	1.05193457
62	MP0005367_renal/urinary_system_phenotyp	1.03823439
63	MP0000516_abnormal_urinary_system	1.03823439
64	MP0008872_abnormal_physiological_respon	1.03423486
65	MP0002234_abnormal_pharynx_morphology	0.98433299
66	MP0005551_abnormal_eye_electrophysiolog	0.97666521
67	MP0004957_abnormal_blastocyst_morpholog	0.97355584
68	MP0001905_abnormal_dopamine_level	0.95077226
69	MP0002928_abnormal_bile_duct	0.94971001
70	MP0009745_abnormal_behavioral_response	0.94206491
71	MP0002282_abnormal_trachea_morphology	0.94112609
72	MP0002751_abnormal_autonomic_nervous	0.92274063
73	MP0000778_abnormal_nervous_system	0.91128581
74	MP0002735_abnormal_chemical_nociception	0.90253984
75	MP0002210_abnormal_sex_determination	0.87693390
76	MP0002160_abnormal_reproductive_system	0.87012694
77	MP0008775_abnormal_heart_ventricle	0.86724141
78	MP0002272_abnormal_nervous_system	0.86501055
79	MP0002064_seizures	0.86161396
80	MP0002734_abnormal_mechanical_nocicepti	0.85517512
81	MP0006035_abnormal_mitochondrial_morpho	0.85406037
82	MP0005389_reproductive_system_phenotype	0.85396685
83	MP0002111_abnormal_tail_morphology	0.84702681
84	MP0002638_abnormal_pupillary_reflex	0.84046037
85	MP0004019_abnormal_vitamin_homeostasis	0.83147614
86	MP0009046_muscle_twitch	0.82812410
87	MP0008877_abnormal_DNA_methylation	0.82646238
88	MP0002233_abnormal_nose_morphology	0.80713666
89	MP0005195_abnormal_posterior_eye	0.80460476
90	MP0003638_abnormal_response/metabolism_	0.80020878
91	MP0008004_abnormal_stomach_pH	0.79157192
92	MP0002163_abnormal_gland_morphology	0.77727916
93	MP0002653_abnormal_ependyma_morphology	0.77721706
94	MP0003755_abnormal_palate_morphology	0.77271196
95	MP0001764_abnormal_homeostasis	0.76956842
96	MP0005220_abnormal_exocrine_pancreas	0.76872833
97	MP0002752_abnormal_somatic_nervous	0.76050720
98	MP0002095_abnormal_skin_pigmentation	0.75958144
99	MP0001919_abnormal_reproductive_system	0.75112739
100	MP0003786_premature_aging	0.74258443

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal number of erythroid precursors (HP:0012131)	5.05055865
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.49636256
3	Acute necrotizing encephalopathy (HP:0006965)	4.21374487
4	Renal Fanconi syndrome (HP:0001994)	4.12919534
5	Mitochondrial inheritance (HP:0001427)	3.94518117
6	Increased hepatocellular lipid droplets (HP:0006565)	3.82928635
7	Esophageal atresia (HP:0002032)	3.79003144
8	Acute encephalopathy (HP:0006846)	3.74910185
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.68033998
10	Macrocytic anemia (HP:0001972)	3.56221507
11	Progressive macrocephaly (HP:0004481)	3.51901496
12	Reticulocytopenia (HP:0001896)	3.50202926
13	Congenital, generalized hypertrichosis (HP:0004540)	3.49494364
14	Increased CSF lactate (HP:0002490)	3.47686973
15	Hepatic necrosis (HP:0002605)	3.36594486
16	Hepatocellular necrosis (HP:0001404)	3.21791286
17	Lipid accumulation in hepatocytes (HP:0006561)	3.20929548
18	Abnormality of renal resorption (HP:0011038)	2.92244962
19	Abnormality of midbrain morphology (HP:0002418)	2.84569290
20	Molar tooth sign on MRI (HP:0002419)	2.84569290
21	Septo-optic dysplasia (HP:0100842)	2.82034936
22	True hermaphroditism (HP:0010459)	2.75498285
23	Exertional dyspnea (HP:0002875)	2.73578139
24	Gastrointestinal atresia (HP:0002589)	2.71865451
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.59667646
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.59667646
27	Pallor (HP:0000980)	2.57163047
28	Increased serum pyruvate (HP:0003542)	2.56039843
29	Generalized aminoaciduria (HP:0002909)	2.49453355
30	Concave nail (HP:0001598)	2.47158161
31	Increased intramyocellular lipid droplets (HP:0012240)	2.46437423
32	Cerebral edema (HP:0002181)	2.41806765
33	Methylmalonic acidemia (HP:0002912)	2.34750558
34	Nephronophthisis (HP:0000090)	2.34149211
35	Pancreatic cysts (HP:0001737)	2.33456155
36	Glycosuria (HP:0003076)	2.33312098
37	Abnormality of urine glucose concentration (HP:0011016)	2.33312098
38	Nausea (HP:0002018)	2.31531490
39	Renal cortical cysts (HP:0000803)	2.30780009
40	Hypoglycemic coma (HP:0001325)	2.26418680
41	Abnormal pupillary function (HP:0007686)	2.25872488
42	Abnormality of methionine metabolism (HP:0010901)	2.24479549
43	Meckel diverticulum (HP:0002245)	2.24388015
44	Pancreatic fibrosis (HP:0100732)	2.21972761
45	Increased serum lactate (HP:0002151)	2.20510004
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.15964633
47	Bilateral microphthalmos (HP:0007633)	2.13432426
48	Abnormal number of incisors (HP:0011064)	2.11872882
49	Abnormality of the ileum (HP:0001549)	2.11220192
50	Abnormality of the labia minora (HP:0012880)	2.09746698
51	Abnormality of homocysteine metabolism (HP:0010919)	2.09353274
52	Homocystinuria (HP:0002156)	2.09353274
53	Optic nerve hypoplasia (HP:0000609)	2.09136398
54	Respiratory difficulties (HP:0002880)	2.06283187
55	3-Methylglutaconic aciduria (HP:0003535)	2.06239829
56	Congenital stationary night blindness (HP:0007642)	2.06106545
57	Male pseudohermaphroditism (HP:0000037)	2.05012040
58	Medial flaring of the eyebrow (HP:0010747)	2.04929151
59	Methylmalonic aciduria (HP:0012120)	2.04652867
60	Respiratory failure (HP:0002878)	2.02238086
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01631663
62	Paralysis (HP:0003470)	2.01454303
63	Anophthalmia (HP:0000528)	2.01282544
64	Optic disc pallor (HP:0000543)	2.00472060
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99262578
66	Maternal diabetes (HP:0009800)	1.95262420
67	Abnormality of glycolysis (HP:0004366)	1.93689850
68	Colon cancer (HP:0003003)	1.92424424
69	Megaloblastic anemia (HP:0001889)	1.91942750
70	Abnormality of the anterior horn cell (HP:0006802)	1.91304680
71	Degeneration of anterior horn cells (HP:0002398)	1.91304680
72	Aplastic anemia (HP:0001915)	1.90724680
73	Type 2 muscle fiber atrophy (HP:0003554)	1.89490057
74	Leukodystrophy (HP:0002415)	1.89326084
75	Lactic acidosis (HP:0003128)	1.88494450
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87005344
77	Hypoplasia of the fovea (HP:0007750)	1.87005344
78	Rib fusion (HP:0000902)	1.82411843
79	Abnormality of the fovea (HP:0000493)	1.81400818
80	Increased muscle lipid content (HP:0009058)	1.80479617
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78198844
82	Hypoplasia of the pons (HP:0012110)	1.77997629
83	Absent septum pellucidum (HP:0001331)	1.77237310
84	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.76997668
85	Triphalangeal thumb (HP:0001199)	1.76616743
86	Partial duplication of the phalanx of hand (HP:0009999)	1.76170603
87	Prolonged bleeding time (HP:0003010)	1.75664147
88	Poikilocytosis (HP:0004447)	1.75476794
89	Pendular nystagmus (HP:0012043)	1.75448756
90	Duodenal stenosis (HP:0100867)	1.74774572
91	Small intestinal stenosis (HP:0012848)	1.74774572
92	Abnormality of the pons (HP:0007361)	1.74060369
93	Lethargy (HP:0001254)	1.73705999
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.73056803
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73056803
96	Hypoplastic left heart (HP:0004383)	1.72036422
97	Limb dystonia (HP:0002451)	1.71905392
98	Hypothermia (HP:0002045)	1.71828075
99	Poor suck (HP:0002033)	1.69857096
100	Muscle fiber atrophy (HP:0100295)	1.67568137

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.52102130
2	TAOK2	4.94225467
3	VRK2	4.14225964
4	NME1	3.13264636
5	BUB1	2.91960755
6	PNCK	2.68706893
7	MAPK15	2.68143247
8	STK16	2.56634396
9	VRK1	2.49672986
10	ZAK	2.48670710
11	MAP2K6	2.28756881
12	MST4	2.14136476
13	WNK3	2.11514814
14	TNIK	2.10268866
15	BMPR1B	1.97587198
16	TSSK6	1.81101040
17	PLK4	1.80203506
18	WEE1	1.70978700
19	EPHB2	1.68898786
20	CDC7	1.68538369
21	PLK3	1.61319221
22	ADRBK2	1.60498591
23	MAP4K2	1.54545576
24	TAF1	1.48078608
25	MAP3K5	1.45541977
26	SRPK1	1.41950806
27	DYRK2	1.37116489
28	WNK4	1.35691002
29	MAPKAPK3	1.26780308
30	SIK2	1.24323087
31	FGFR2	1.21024461
32	MKNK2	1.18115774
33	PASK	1.13746359
34	CASK	1.11307466
35	DYRK3	1.09985502
36	NUAK1	1.09160587
37	MKNK1	1.04218565
38	TTK	1.02402974
39	GRK1	0.96460881
40	EIF2AK1	0.96223705
41	PRKCG	0.94034169
42	TAOK3	0.93468949
43	CHEK2	0.92898568
44	PHKG2	0.85326036
45	PHKG1	0.85326036
46	NEK2	0.82970543
47	MUSK	0.82111730
48	CDK3	0.78445703
49	BMX	0.75295501
50	PLK1	0.74189547
51	MAPK13	0.68436789
52	STK4	0.67149202
53	CSNK1G1	0.66954069
54	MAPKAPK5	0.66507595
55	TGFBR1	0.63091812
56	OXSR1	0.57398020
57	FRK	0.56789193
58	MAP3K4	0.54691440
59	MAP2K7	0.53451816
60	CSNK1G3	0.52820526
61	AURKA	0.52317258
62	ACVR1B	0.52065599
63	MAP3K10	0.51873300
64	NTRK2	0.51185834
65	STK39	0.50525212
66	ATR	0.50478448
67	BRSK2	0.49482564
68	INSRR	0.49431096
69	MAP2K2	0.49409569
70	EIF2AK2	0.47530104
71	CSNK2A1	0.46731387
72	CSNK1G2	0.45322113
73	CDK7	0.43578271
74	MYLK	0.42690659
75	RPS6KA5	0.39320964
76	AURKB	0.38741731
77	PLK2	0.37740481
78	CSNK2A2	0.37403233
79	RIPK4	0.36862139
80	NME2	0.34700248
81	ADRBK1	0.30219594
82	CSNK1E	0.30177408
83	NLK	0.29297580
84	PRKG1	0.27362916
85	PRKACB	0.26821556
86	ATM	0.25220072
87	ILK	0.24605216
88	PRKACA	0.23216136
89	GRK6	0.22940325
90	PKN1	0.22823331
91	TIE1	0.22421964
92	CSNK1A1	0.22339158
93	PDK2	0.22226010
94	ERBB2	0.22088254
95	ABL2	0.21978095
96	MAP3K8	0.19661028
97	EIF2AK3	0.18225869
98	GRK5	0.18208233
99	NTRK3	0.18056585
100	MARK1	0.17947266

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.04918899
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.51716994
3	Parkinsons disease_Homo sapiens_hsa05012	4.05585786
4	RNA polymerase_Homo sapiens_hsa03020	3.08419229
5	Huntingtons disease_Homo sapiens_hsa05016	2.93791243
6	Alzheimers disease_Homo sapiens_hsa05010	2.61239105
7	Proteasome_Homo sapiens_hsa03050	2.52134795
8	Mismatch repair_Homo sapiens_hsa03430	2.49297265
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.48626415
10	Protein export_Homo sapiens_hsa03060	2.47274585
11	Homologous recombination_Homo sapiens_hsa03440	2.41932185
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.32542671
13	DNA replication_Homo sapiens_hsa03030	2.22904684
14	Spliceosome_Homo sapiens_hsa03040	2.02749194
15	One carbon pool by folate_Homo sapiens_hsa00670	1.88210747
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81701537
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.75591597
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.70314463
19	Fatty acid elongation_Homo sapiens_hsa00062	1.69910982
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66529556
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.65042442
22	Basal transcription factors_Homo sapiens_hsa03022	1.63266115
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61656954
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.61482853
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.44793821
26	Purine metabolism_Homo sapiens_hsa00230	1.36930570
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.35059516
28	RNA degradation_Homo sapiens_hsa03018	1.31326048
29	Base excision repair_Homo sapiens_hsa03410	1.26545287
30	Folate biosynthesis_Homo sapiens_hsa00790	1.19782435
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17337263
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14454127
33	Basal cell carcinoma_Homo sapiens_hsa05217	1.10687132
34	Sulfur relay system_Homo sapiens_hsa04122	1.06149314
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04910861
36	RNA transport_Homo sapiens_hsa03013	1.01849511
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95104858
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91946235
39	Glutathione metabolism_Homo sapiens_hsa00480	0.88705655
40	Non-homologous end-joining_Homo sapiens_hsa03450	0.88145442
41	Pyruvate metabolism_Homo sapiens_hsa00620	0.86104151
42	Cocaine addiction_Homo sapiens_hsa05030	0.85522888
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85494834
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85041690
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80575779
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80372458
47	Cell cycle_Homo sapiens_hsa04110	0.76515526
48	Phototransduction_Homo sapiens_hsa04744	0.74674629
49	Metabolic pathways_Homo sapiens_hsa01100	0.70047208
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.69872528
51	Butanoate metabolism_Homo sapiens_hsa00650	0.69386877
52	Regulation of autophagy_Homo sapiens_hsa04140	0.68640338
53	Nicotine addiction_Homo sapiens_hsa05033	0.68203299
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.68026748
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65923254
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.65448143
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65356894
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62365591
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61870614
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.60745828
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59434067
62	Serotonergic synapse_Homo sapiens_hsa04726	0.58740729
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54234489
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52384604
65	Propanoate metabolism_Homo sapiens_hsa00640	0.51180676
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50963763
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50006332
68	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48548989
69	Oocyte meiosis_Homo sapiens_hsa04114	0.48177115
70	Peroxisome_Homo sapiens_hsa04146	0.47425767
71	Wnt signaling pathway_Homo sapiens_hsa04310	0.47420963
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.46629742
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43098143
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.42759703
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41923036
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40310458
77	Retinol metabolism_Homo sapiens_hsa00830	0.39549868
78	Alcoholism_Homo sapiens_hsa05034	0.38459178
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38314988
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.38185336
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37805222
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36935297
83	Taste transduction_Homo sapiens_hsa04742	0.35723860
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33855618
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.33689985
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33660287
87	GABAergic synapse_Homo sapiens_hsa04727	0.33640339
88	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33570361
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33505327
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31618923
91	Circadian entrainment_Homo sapiens_hsa04713	0.26348177
92	Morphine addiction_Homo sapiens_hsa05032	0.25662298
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24681772
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.24265655
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.24133879
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24103228
97	Olfactory transduction_Homo sapiens_hsa04740	0.22141807
98	Gap junction_Homo sapiens_hsa04540	0.22112376
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.19737907
100	Amphetamine addiction_Homo sapiens_hsa05031	0.17624101

PPT2-EGFL8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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