PPTC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.09725680
2sarcomere organization (GO:0045214)5.59504552
3negative regulation of potassium ion transmembrane transport (GO:1901380)5.40789365
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.28317793
5cardiac myofibril assembly (GO:0055003)5.07896406
6carnitine shuttle (GO:0006853)4.96070441
7tricarboxylic acid cycle (GO:0006099)4.95798262
8plasma membrane repair (GO:0001778)4.93497998
9positive regulation of gamma-delta T cell activation (GO:0046645)4.91686406
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.78865655
11cardiac muscle contraction (GO:0060048)4.69859711
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.66232479
13myofibril assembly (GO:0030239)4.60722479
14regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.46537825
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.44351084
16sarcoplasmic reticulum calcium ion transport (GO:0070296)4.42990438
17fatty acid transmembrane transport (GO:1902001)4.42822451
18muscle filament sliding (GO:0030049)4.37600474
19actin-myosin filament sliding (GO:0033275)4.37600474
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.29263372
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.27212868
22positive regulation by symbiont of host defense response (GO:0052509)4.26519204
23modulation by symbiont of host defense response (GO:0052031)4.26519204
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26519204
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26519204
26positive regulation by organism of defense response of other organism involved in symbiotic interact4.26519204
27modulation by symbiont of host immune response (GO:0052553)4.26519204
28negative regulation of erythrocyte differentiation (GO:0045647)4.25953671
29negative regulation of cell killing (GO:0031342)4.23589103
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23589103
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.21776849
32regulation of skeletal muscle contraction (GO:0014819)4.19838245
33response to peptidoglycan (GO:0032494)4.11031987
34cell communication involved in cardiac conduction (GO:0086065)4.06444422
35regulation of acyl-CoA biosynthetic process (GO:0050812)4.03691745
36regulation of gamma-delta T cell activation (GO:0046643)3.98273436
372-oxoglutarate metabolic process (GO:0006103)3.96395329
38striated muscle contraction (GO:0006941)3.92010014
39germinal center formation (GO:0002467)3.89270973
40macrophage activation involved in immune response (GO:0002281)3.87914967
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86568689
42regulation of actin filament-based movement (GO:1903115)3.85777159
43carnitine transmembrane transport (GO:1902603)3.85407676
44regulation of relaxation of muscle (GO:1901077)3.81261673
45regulation of cell communication by electrical coupling (GO:0010649)3.80178619
46regulation of B cell receptor signaling pathway (GO:0050855)3.80013326
47ventricular cardiac muscle cell action potential (GO:0086005)3.76039889
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74115411
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73435149
50regulation of cofactor metabolic process (GO:0051193)3.73384821
51regulation of coenzyme metabolic process (GO:0051196)3.73384821
52cell communication by electrical coupling (GO:0010644)3.72862605
53antigen processing and presentation of endogenous antigen (GO:0019883)3.72168241
54regulation of membrane repolarization (GO:0060306)3.70290184
55response to muramyl dipeptide (GO:0032495)3.69554862
56actomyosin structure organization (GO:0031032)3.69106634
57carnitine transport (GO:0015879)3.63027742
58amino-acid betaine transport (GO:0015838)3.63027742
59regulation of gamma-delta T cell differentiation (GO:0045586)3.62603470
60cardiac muscle hypertrophy (GO:0003300)3.61755571
61actin-mediated cell contraction (GO:0070252)3.58383874
62positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.55405830
63cardiac muscle cell development (GO:0055013)3.53065481
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.52360767
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52307160
66NADH metabolic process (GO:0006734)3.51853473
67striated muscle hypertrophy (GO:0014897)3.47626808
68lysine catabolic process (GO:0006554)3.46174282
69lysine metabolic process (GO:0006553)3.46174282
70detection of other organism (GO:0098543)3.44420555
71regulation of interferon-beta biosynthetic process (GO:0045357)3.41339460
72neutrophil activation involved in immune response (GO:0002283)3.40873973
73regulation of calcium ion transmembrane transport (GO:1903169)3.32811422
74regulation of calcium ion transmembrane transporter activity (GO:1901019)3.32811422
75regulation of necroptotic process (GO:0060544)3.31404082
76succinate metabolic process (GO:0006105)3.30260522
77B cell receptor signaling pathway (GO:0050853)3.29833020
78cardiac cell development (GO:0055006)3.29373519
79potassium ion import (GO:0010107)3.28434836
80sodium ion export (GO:0071436)3.28262458
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27492703
82creatine metabolic process (GO:0006600)3.27383433
83negative regulation of interleukin-12 production (GO:0032695)3.25824037
84cellular extravasation (GO:0045123)3.25425407
85detection of bacterium (GO:0016045)3.24895630
86oxaloacetate metabolic process (GO:0006107)3.24131689
87detection of molecule of bacterial origin (GO:0032490)3.24050325
88negative regulation of potassium ion transport (GO:0043267)3.21987430
89aspartate family amino acid catabolic process (GO:0009068)3.19401869
90relaxation of cardiac muscle (GO:0055119)3.18703151
91regulation of striated muscle contraction (GO:0006942)3.18177444
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18176878
93regulation of sequestering of triglyceride (GO:0010889)3.13747630
94regulation of fatty acid oxidation (GO:0046320)3.12138885
95bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11819676
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08572878
97regulation of the force of heart contraction (GO:0002026)3.07386876
98negative regulation of T cell mediated immunity (GO:0002710)3.07255659
99lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07147079
100muscle hypertrophy (GO:0014896)3.06937451
101cardiac conduction (GO:0061337)3.06615127
102detection of external biotic stimulus (GO:0098581)3.05481239
103actin filament-based movement (GO:0030048)3.04898154
104cardiac muscle cell action potential involved in contraction (GO:0086002)3.04069021
105regulation of synapse structural plasticity (GO:0051823)3.03281282
106dicarboxylic acid biosynthetic process (GO:0043650)3.00160061
107negative regulation of necroptotic process (GO:0060546)3.00090561
108regulation of sulfur metabolic process (GO:0042762)2.99243668
109immunoglobulin mediated immune response (GO:0016064)2.98631175
110cardiac muscle cell action potential (GO:0086001)2.98317585
111activation of protein kinase A activity (GO:0034199)2.97952811
112JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96033158
113positive regulation of cation channel activity (GO:2001259)2.94677041
114cardiac muscle adaptation (GO:0014887)2.94239453
115cardiac muscle hypertrophy in response to stress (GO:0014898)2.94239453
116muscle hypertrophy in response to stress (GO:0003299)2.94239453
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93317449
118response to host defenses (GO:0052200)2.93001328
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93001328
120response to host (GO:0075136)2.93001328
121heart trabecula formation (GO:0060347)2.92969227
122regulation of T-helper 2 cell differentiation (GO:0045628)2.91321379
123response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91314203
124response to host immune response (GO:0052572)2.91314203
125skeletal muscle contraction (GO:0003009)2.90448039
126glycogen catabolic process (GO:0005980)2.89707711
127skeletal muscle adaptation (GO:0043501)2.85735581
128positive thymic T cell selection (GO:0045059)2.85186190
129NIK/NF-kappaB signaling (GO:0038061)2.84817711
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.84333518
131tricarboxylic acid metabolic process (GO:0072350)2.83927872
132defense response to protozoan (GO:0042832)2.83819399
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.82527455
134positive regulation of interferon-alpha production (GO:0032727)2.81304527
135adult heart development (GO:0007512)2.81042272
136T-helper 1 type immune response (GO:0042088)2.80769958
137regulation of heart rate by cardiac conduction (GO:0086091)2.80571464
138interferon-gamma-mediated signaling pathway (GO:0060333)2.80383997
139glucan catabolic process (GO:0009251)2.79467674
140regulation of cardiac muscle cell contraction (GO:0086004)2.79246547
1413-UTR-mediated mRNA stabilization (GO:0070935)2.78076572
142regulation of sarcomere organization (GO:0060297)2.77153346
143striated muscle adaptation (GO:0014888)2.75642894
144positive regulation of B cell differentiation (GO:0045579)2.74649711
145intracellular lipid transport (GO:0032365)2.73747420
146cellular potassium ion homeostasis (GO:0030007)2.73462580
147oxygen transport (GO:0015671)2.73172471
148B cell homeostasis (GO:0001782)2.72760190
149positive regulation of sodium ion transport (GO:0010765)2.72084576
150muscle contraction (GO:0006936)2.71821772
151cellular response to type I interferon (GO:0071357)2.71723903
152type I interferon signaling pathway (GO:0060337)2.71723903
153regulation of cation channel activity (GO:2001257)2.71424148
154response to protozoan (GO:0001562)2.70418712
155regulation of T cell tolerance induction (GO:0002664)2.69691188
156regulation of interferon-alpha production (GO:0032647)2.69395786
157regulation of mast cell degranulation (GO:0043304)2.68611990
158response to type I interferon (GO:0034340)2.68350309
159detection of biotic stimulus (GO:0009595)2.67428758
160cardiac muscle tissue morphogenesis (GO:0055008)2.67409196
161detection of calcium ion (GO:0005513)2.67156293
162leukocyte aggregation (GO:0070486)2.66510621
163regulation of tolerance induction (GO:0002643)2.64177566
164protein localization to endosome (GO:0036010)2.63460025
165quaternary ammonium group transport (GO:0015697)2.63103085
166negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62909126
167fatty acid beta-oxidation (GO:0006635)2.62550533
168regulation of leukocyte degranulation (GO:0043300)2.62516706
169myeloid cell activation involved in immune response (GO:0002275)2.60916706
170macrophage activation (GO:0042116)2.60839057
171tolerance induction (GO:0002507)2.59706585
172positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59526223
173response to interleukin-15 (GO:0070672)2.59150539
174negative thymic T cell selection (GO:0045060)2.58335711
175regulation of T-helper 1 cell differentiation (GO:0045625)2.57596436
176T cell migration (GO:0072678)2.57098428
177histone H3-K36 demethylation (GO:0070544)2.57060572
178negative regulation of leukocyte mediated immunity (GO:0002704)2.54941790
179T cell selection (GO:0045058)2.53790965
180CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.53780878
181negative regulation of T-helper cell differentiation (GO:0045623)2.53616057
182negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.53616057
183cellular response to thyroid hormone stimulus (GO:0097067)2.52433271
184myeloid dendritic cell differentiation (GO:0043011)2.51335436
185positive T cell selection (GO:0043368)2.48326454
186response to laminar fluid shear stress (GO:0034616)2.48107980
187regulation of necrotic cell death (GO:0010939)2.47672063
188regulation of B cell differentiation (GO:0045577)2.46337736
189production of molecular mediator involved in inflammatory response (GO:0002532)2.46051475
190regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45684896
191regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45116742
192negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44320298
193regulation of mast cell activation involved in immune response (GO:0033006)2.44233994
194negative T cell selection (GO:0043383)2.43973802
195microglial cell activation (GO:0001774)2.43636545
196regulation of alpha-beta T cell proliferation (GO:0046640)2.42310191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.12045438
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.77328317
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39238132
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03854124
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01539062
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86078191
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83591328
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72429741
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68802633
10VDR_21846776_ChIP-Seq_THP-1_Human2.61401117
11* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.59083464
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.52549092
13* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40853356
14VDR_24763502_ChIP-Seq_THP-1_Human2.38604803
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.34030871
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31760132
17TBX20_22080862_ChIP-Seq_HEART_Mouse2.30123808
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.30123808
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28303794
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.23688771
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20925866
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.18358562
23MYB_26560356_Chip-Seq_TH2_Human2.15662681
24* RARB_27405468_Chip-Seq_BRAIN_Mouse2.13312109
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10311644
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07171604
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05858213
28ZNF263_19887448_ChIP-Seq_K562_Human2.02173801
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01511229
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01199254
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98392894
32SCL_19346495_ChIP-Seq_HPC-7_Human1.96203736
33KDM2B_26808549_Chip-Seq_DND41_Human1.94536586
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90638354
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90636117
36* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88205450
37DROSHA_22980978_ChIP-Seq_HELA_Human1.88140300
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.87682722
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86966021
40SPI1_23547873_ChIP-Seq_NB4_Human1.82637738
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80737176
42EZH2_22144423_ChIP-Seq_EOC_Human1.80680002
43* MYB_26560356_Chip-Seq_TH1_Human1.79811935
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.77201558
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77163627
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74435430
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72244327
48* LXR_22158963_ChIP-Seq_LIVER_Mouse1.70462879
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66895315
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66656059
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65318290
52TCF7_22412390_ChIP-Seq_EML_Mouse1.62100618
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60259429
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.58261977
55* RXR_22158963_ChIP-Seq_LIVER_Mouse1.58227774
56VDR_24787735_ChIP-Seq_THP-1_Human1.56321546
57KDM2B_26808549_Chip-Seq_K562_Human1.55217884
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53050734
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50384061
60PU_27001747_Chip-Seq_BMDM_Mouse1.49007765
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48373766
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46327260
63* MAF_26560356_Chip-Seq_TH2_Human1.45203007
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43044930
65CLOCK_20551151_ChIP-Seq_293T_Human1.42321459
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41441894
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36800538
68MYC_22102868_ChIP-Seq_BL_Human1.36030621
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34581377
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34049177
71* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33756346
72* KDM2B_26808549_Chip-Seq_JURKAT_Human1.33043226
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30317270
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28599280
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28519752
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27985982
77GATA1_22025678_ChIP-Seq_K562_Human1.27541588
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27372059
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27162694
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25792451
81LXR_22292898_ChIP-Seq_THP-1_Human1.24437838
82GATA3_27048872_Chip-Seq_THYMUS_Human1.24176917
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23638094
84RUNX_20019798_ChIP-Seq_JUKART_Human1.23510158
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21859024
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21541096
87* SPI1_23127762_ChIP-Seq_K562_Human1.19810950
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.18192676
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16577230
90GATA1_19941826_ChIP-Seq_K562_Human1.16510054
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.15841677
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15142180
93* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14735432
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14596450
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14331375
96* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13468874
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12766806
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12157136
99NCOR1_26117541_ChIP-Seq_K562_Human1.11722935
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11293109
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10994855
102CREB1_26743006_Chip-Seq_LNCaP_Human1.10362972
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10350373
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10341341
105RACK7_27058665_Chip-Seq_MCF-7_Human1.10295313
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09157475
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08877850
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05828776
109MAF_26560356_Chip-Seq_TH1_Human1.05452980
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04053390
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02397532
112ATF3_27146783_Chip-Seq_COLON_Human1.00936562
113MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00782016
114GATA2_19941826_ChIP-Seq_K562_Human0.99983708
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99528880
116RXR_22108803_ChIP-Seq_LS180_Human0.99394998
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99006320
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.98584129
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97713816
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97622710
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.96696044
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96606501
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.96507087
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96208917
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94812822
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93905447
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.93668139
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93642180
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93254150
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93220715
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92873314
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92717792
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.92548248
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92507939
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92014918
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92014918
137* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91870205
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91347970
139TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91113576
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90958960
141BP1_19119308_ChIP-ChIP_Hs578T_Human0.90602388
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90303007
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90127968
144UTX_26944678_Chip-Seq_JUKART_Human0.90018640
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89640164
146TFEB_21752829_ChIP-Seq_HELA_Human0.89369660
147SMC4_20622854_ChIP-Seq_HELA_Human0.88867190
148CTCF_27219007_Chip-Seq_Bcells_Human0.88368404
149* AR_19668381_ChIP-Seq_PC3_Human0.88232645
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87959901
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87121595
152CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86827647
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86388239
154SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86275602
155NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86148921
156SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85894727
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.85776340
158P68_20966046_ChIP-Seq_HELA_Human0.84685693
159AHR_22903824_ChIP-Seq_MCF-7_Human0.84332488
160TP63_22573176_ChIP-Seq_HFKS_Human0.83596088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.47227664
2MP0003646_muscle_fatigue5.34606998
3MP0000751_myopathy4.38310855
4MP0004084_abnormal_cardiac_muscle4.06962086
5MP0004036_abnormal_muscle_relaxation3.57930174
6MP0005451_abnormal_body_composition3.57848015
7MP0004215_abnormal_myocardial_fiber3.49598042
8MP0000749_muscle_degeneration3.19174803
9MP0004130_abnormal_muscle_cell3.19026108
10MP0003436_decreased_susceptibility_to3.04969968
11MP0005330_cardiomyopathy2.92214604
12MP0002822_catalepsy2.84799739
13MP0001835_abnormal_antigen_presentation2.84143910
14MP0004087_abnormal_muscle_fiber2.81495885
15MP0003724_increased_susceptibility_to2.39788645
16MP0004145_abnormal_muscle_electrophysio2.38576580
17MP0005620_abnormal_muscle_contractility2.33301768
18MP0002972_abnormal_cardiac_muscle2.32137291
19MP0003763_abnormal_thymus_physiology2.32046007
20MP0002269_muscular_atrophy2.31525090
21MP0001800_abnormal_humoral_immune2.30056072
22MP0002106_abnormal_muscle_physiology2.27308305
23MP0005000_abnormal_immune_tolerance2.23045259
24MP0005387_immune_system_phenotype2.22340917
25MP0001790_abnormal_immune_system2.22340917
26MP0004510_myositis2.21243283
27MP0004859_abnormal_synaptic_plasticity2.21035818
28MP0000685_abnormal_immune_system2.16936157
29MP0004484_altered_response_of2.16738480
30MP0000747_muscle_weakness2.15740504
31MP0000750_abnormal_muscle_regeneration2.09987097
32MP0002419_abnormal_innate_immunity2.08672019
33MP0010630_abnormal_cardiac_muscle2.05996646
34MP0008775_abnormal_heart_ventricle2.05084739
35MP0001544_abnormal_cardiovascular_syste2.02299706
36MP0005385_cardiovascular_system_phenoty2.02299706
37MP0009785_altered_susceptibility_to1.96472423
38MP0005025_abnormal_response_to1.95843035
39MP0002452_abnormal_antigen_presenting1.94723707
40MP0003137_abnormal_impulse_conducting1.94072130
41MP0002723_abnormal_immune_serum1.93785379
42MP0000759_abnormal_skeletal_muscle1.89537949
43MP0004947_skin_inflammation1.86261724
44MP0002420_abnormal_adaptive_immunity1.83835468
45MP0005671_abnormal_response_to1.82686920
46MP0001819_abnormal_immune_cell1.81610138
47MP0004233_abnormal_muscle_weight1.78917840
48MP0005369_muscle_phenotype1.77791433
49MP0002148_abnormal_hypersensitivity_rea1.77299646
50MP0005666_abnormal_adipose_tissue1.76737159
51MP0003705_abnormal_hypodermis_morpholog1.75721130
52MP0008961_abnormal_basal_metabolism1.74215981
53MP0004185_abnormal_adipocyte_glucose1.73501656
54MP0006138_congestive_heart_failure1.72587095
55MP0003221_abnormal_cardiomyocyte_apopto1.69891997
56MP0004085_abnormal_heartbeat1.67371405
57MP0002909_abnormal_adrenal_gland1.64749882
58MP0002398_abnormal_bone_marrow1.60475569
59MP0003656_abnormal_erythrocyte_physiolo1.55776701
60MP0002405_respiratory_system_inflammati1.55331272
61MP0002396_abnormal_hematopoietic_system1.54101395
62MP0001853_heart_inflammation1.53176768
63MP0002009_preneoplasia1.52791752
64MP0000716_abnormal_immune_system1.48505201
65MP0004808_abnormal_hematopoietic_stem1.47374301
66MP0010155_abnormal_intestine_physiology1.42101055
67MP0008057_abnormal_DNA_replication1.39897409
68MP0009333_abnormal_splenocyte_physiolog1.39288641
69MP0006082_CNS_inflammation1.39183292
70MP0005464_abnormal_platelet_physiology1.36691587
71MP0003091_abnormal_cell_migration1.36346813
72MP0006036_abnormal_mitochondrial_physio1.35794160
73MP0002332_abnormal_exercise_endurance1.33569041
74MP0001533_abnormal_skeleton_physiology1.31569342
75MP0005375_adipose_tissue_phenotype1.31170918
76MP0008260_abnormal_autophagy1.31076099
77MP0003300_gastrointestinal_ulcer1.30552246
78MP0002998_abnormal_bone_remodeling1.30355130
79MP0003453_abnormal_keratinocyte_physiol1.29532560
80MP0002722_abnormal_immune_system1.26086595
81MP0001845_abnormal_inflammatory_respons1.25212042
82MP0000703_abnormal_thymus_morphology1.25083288
83MP0000689_abnormal_spleen_morphology1.24801368
84MP0003828_pulmonary_edema1.24004000
85MP0005076_abnormal_cell_differentiation1.22074656
86MP0005670_abnormal_white_adipose1.21697580
87MP0005058_abnormal_lysosome_morphology1.21471640
88MP0000858_altered_metastatic_potential1.20682854
89MP0002429_abnormal_blood_cell1.19198590
90MP0009780_abnormal_chondrocyte_physiolo1.18274504
91MP0003172_abnormal_lysosome_physiology1.17789033
92MP0001851_eye_inflammation1.15820467
93MP0004381_abnormal_hair_follicle1.11455277
94MP0002006_tumorigenesis1.11312441
95MP0001873_stomach_inflammation1.10602158
96MP0009278_abnormal_bone_marrow1.09019351
97MP0010352_gastrointestinal_tract_polyps1.08225826
98MP0003635_abnormal_synaptic_transmissio1.04430685
99MP0002971_abnormal_brown_adipose1.02523860
100MP0003045_fibrosis1.02387983
101MP0005397_hematopoietic_system_phenotyp1.02084870
102MP0001545_abnormal_hematopoietic_system1.02084870
103MP0002138_abnormal_hepatobiliary_system1.01746953
104MP0005085_abnormal_gallbladder_physiolo1.01479439
105MP0000013_abnormal_adipose_tissue1.00626907
106MP0000003_abnormal_adipose_tissue0.99663996
107MP0008469_abnormal_protein_level0.99591892
108MP0008569_lethality_at_weaning0.99339458
109MP0005360_urolithiasis0.97588725
110MP0004043_abnormal_pH_regulation0.95754369
111MP0005310_abnormal_salivary_gland0.92131904
112MP0004270_analgesia0.91383104
113MP0008004_abnormal_stomach_pH0.89876118
114MP0000266_abnormal_heart_morphology0.89497756
115MP0002127_abnormal_cardiovascular_syste0.89374980
116MP0005535_abnormal_body_temperature0.84266851
117MP0003329_amyloid_beta_deposits0.83540948
118MP0003252_abnormal_bile_duct0.82273979
119MP0002078_abnormal_glucose_homeostasis0.82183752
120MP0008874_decreased_physiological_sensi0.82101314
121MP0003303_peritoneal_inflammation0.81699042
122MP0010234_abnormal_vibrissa_follicle0.79728252
123MP0002234_abnormal_pharynx_morphology0.79236671
124MP0006035_abnormal_mitochondrial_morpho0.77961385
125MP0002063_abnormal_learning/memory/cond0.77697769
126MP0005165_increased_susceptibility_to0.77057535
127MP0009840_abnormal_foam_cell0.75448593
128MP0009745_abnormal_behavioral_response0.74631596
129MP0000343_altered_response_to0.74625975
130MP0004924_abnormal_behavior0.74481249
131MP0005386_behavior/neurological_phenoty0.74481249
132MP0005266_abnormal_metabolism0.74147289
133MP0005167_abnormal_blood-brain_barrier0.72964962
134MP0000733_abnormal_muscle_development0.72778056
135MP0005584_abnormal_enzyme/coenzyme_acti0.70097858
136MP0000230_abnormal_systemic_arterial0.69763073
137MP0002118_abnormal_lipid_homeostasis0.68533699
138MP0003566_abnormal_cell_adhesion0.68105776
139MP0003075_altered_response_to0.66248216
140MP0003633_abnormal_nervous_system0.65282538
141MP0002877_abnormal_melanocyte_morpholog0.64637103
142MP0010329_abnormal_lipoprotein_level0.64278739
143MP0005365_abnormal_bile_salt0.63438747
144MP0005319_abnormal_enzyme/_coenzyme0.63115011
145MP0002108_abnormal_muscle_morphology0.61570113
146MP0001765_abnormal_ion_homeostasis0.60126615
147MP0002064_seizures0.60084963
148MP0003191_abnormal_cellular_cholesterol0.58858966
149MP0000604_amyloidosis0.57650226
150MP0009046_muscle_twitch0.57351546
151MP0000609_abnormal_liver_physiology0.56796125
152MP0005166_decreased_susceptibility_to0.56040309
153MP0005187_abnormal_penis_morphology0.55623060
154MP0002128_abnormal_blood_circulation0.54963239
155MP0005332_abnormal_amino_acid0.53988314
156MP0002139_abnormal_hepatobiliary_system0.53720061
157MP0004858_abnormal_nervous_system0.53667182
158MP0010368_abnormal_lymphatic_system0.53565931
159MP0002166_altered_tumor_susceptibility0.53224832

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.25924253
2Sudden death (HP:0001699)5.91186600
3Exercise-induced muscle cramps (HP:0003710)5.72365242
4Calf muscle hypertrophy (HP:0008981)5.00722412
5Myoglobinuria (HP:0002913)4.88068906
6Muscle hypertrophy of the lower extremities (HP:0008968)4.82039889
7Hyporeflexia of lower limbs (HP:0002600)4.67404934
8Ventricular tachycardia (HP:0004756)4.60233533
9Bundle branch block (HP:0011710)4.57760709
10Muscle fiber splitting (HP:0003555)4.35821971
11Atrial fibrillation (HP:0005110)4.31467215
12Eczematoid dermatitis (HP:0000976)4.10337956
13Primary atrial arrhythmia (HP:0001692)4.08134591
14Difficulty running (HP:0009046)4.04240472
15Abnormality of the calf musculature (HP:0001430)3.95715258
16Supraventricular tachycardia (HP:0004755)3.86998369
17Right ventricular cardiomyopathy (HP:0011663)3.85375519
18Supraventricular arrhythmia (HP:0005115)3.78529985
19Abnormality of the left ventricular outflow tract (HP:0011103)3.74537949
20Subaortic stenosis (HP:0001682)3.74537949
21Atrioventricular block (HP:0001678)3.68155806
22Heart block (HP:0012722)3.64452162
23Syncope (HP:0001279)3.63709409
24Increased connective tissue (HP:0009025)3.63501515
25Asymmetric septal hypertrophy (HP:0001670)3.62960374
26Dysmetric saccades (HP:0000641)3.57468564
27EMG: myopathic abnormalities (HP:0003458)3.53519658
28Centrally nucleated skeletal muscle fibers (HP:0003687)3.52900506
29Rhabdomyolysis (HP:0003201)3.52450957
30Recurrent bacterial skin infections (HP:0005406)3.42574550
31Abnormal atrioventricular conduction (HP:0005150)3.40135182
32Lipoatrophy (HP:0100578)3.37952530
33Ventricular fibrillation (HP:0001663)3.36788239
34Ventricular arrhythmia (HP:0004308)3.28221579
35Recurrent abscess formation (HP:0002722)3.25237192
36Myotonia (HP:0002486)3.24108013
37Prolonged QT interval (HP:0001657)3.23457545
38Palpitations (HP:0001962)3.20253423
39Muscle fiber inclusion bodies (HP:0100299)3.10169824
40Abnormality of macrophages (HP:0004311)3.09442557
41Muscle stiffness (HP:0003552)2.99223388
42Dilated cardiomyopathy (HP:0001644)2.96705503
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.95954380
44Difficulty climbing stairs (HP:0003551)2.84250496
45Increased IgE level (HP:0003212)2.80471856
46Mediastinal lymphadenopathy (HP:0100721)2.79361180
47Ketoacidosis (HP:0001993)2.76167373
48Myositis (HP:0100614)2.75892088
49Fatigue (HP:0012378)2.74346330
50Orchitis (HP:0100796)2.67069657
51Increased variability in muscle fiber diameter (HP:0003557)2.64794066
52Recurrent viral infections (HP:0004429)2.63112794
53Type 1 muscle fiber predominance (HP:0003803)2.62399370
54Recurrent gram-negative bacterial infections (HP:0005420)2.60746929
55Retrobulbar optic neuritis (HP:0100654)2.58374487
56Optic neuritis (HP:0100653)2.58374487
57Abnormality of skeletal muscle fiber size (HP:0012084)2.53340205
58Meningitis (HP:0001287)2.52901534
59Gastrointestinal infarctions (HP:0005244)2.52832350
60Abnormal EKG (HP:0003115)2.49619871
61Chest pain (HP:0100749)2.48998753
62Spontaneous hematomas (HP:0007420)2.48867946
63Gastrointestinal stroma tumor (HP:0100723)2.48086284
64Vasculitis (HP:0002633)2.47099280
65Recurrent fungal infections (HP:0002841)2.45997231
66Distal lower limb amyotrophy (HP:0008944)2.38219916
67Stomatitis (HP:0010280)2.34944219
68Cellulitis (HP:0100658)2.33573467
69Nemaline bodies (HP:0003798)2.32153114
70Elevated erythrocyte sedimentation rate (HP:0003565)2.31636362
71Frequent falls (HP:0002359)2.31219964
72Resting tremor (HP:0002322)2.29725016
73Limb-girdle muscle atrophy (HP:0003797)2.27033912
74Facial diplegia (HP:0001349)2.26782672
75Areflexia of lower limbs (HP:0002522)2.24700721
76Ketosis (HP:0001946)2.24674568
77Colitis (HP:0002583)2.23755136
78Recurrent skin infections (HP:0001581)2.23285621
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.23144125
80Slow saccadic eye movements (HP:0000514)2.17564904
81Conjunctival hamartoma (HP:0100780)2.17399533
82EMG: neuropathic changes (HP:0003445)2.17202049
83Hamartoma of the eye (HP:0010568)2.17093335
84Lower limb amyotrophy (HP:0007210)2.15141554
85Gingivitis (HP:0000230)2.14496929
86T lymphocytopenia (HP:0005403)2.13504569
87Arterial thrombosis (HP:0004420)2.13427301
88Abnormality of the fingertips (HP:0001211)2.12768086
89Hypoglycemic coma (HP:0001325)2.10476862
90Chronic mucocutaneous candidiasis (HP:0002728)2.09861503
91Recurrent cutaneous fungal infections (HP:0011370)2.09861503
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09381018
93Keratoconjunctivitis sicca (HP:0001097)2.08765162
94Chronic obstructive pulmonary disease (HP:0006510)2.00956680
95Obstructive lung disease (HP:0006536)2.00956680
96Left ventricular hypertrophy (HP:0001712)2.00581990
97Inflammation of the large intestine (HP:0002037)1.99886249
98Urticaria (HP:0001025)1.99194267
99Gastrointestinal inflammation (HP:0004386)1.98689649
100Autoimmune hemolytic anemia (HP:0001890)1.96623624
101Pheochromocytoma (HP:0002666)1.95484389
102Sudden cardiac death (HP:0001645)1.95043966
103Abnormality of the endocardium (HP:0004306)1.92878362
104Abnormality of T cell number (HP:0011839)1.92877359
105Osteomyelitis (HP:0002754)1.92292203
106Gout (HP:0001997)1.90943345
107Pulmonary infiltrates (HP:0002113)1.90023929
108Distal lower limb muscle weakness (HP:0009053)1.88984467
109Abnormality of fatty-acid metabolism (HP:0004359)1.87816646
110Rapidly progressive (HP:0003678)1.87584008
111Hyperammonemia (HP:0001987)1.87073763
112Neck muscle weakness (HP:0000467)1.86897998
113Progressive external ophthalmoplegia (HP:0000590)1.86401459
114Abnormal social behavior (HP:0012433)1.85938612
115Impaired social interactions (HP:0000735)1.85938612
116Viral hepatitis (HP:0006562)1.84806208
117Testicular atrophy (HP:0000029)1.84788931
118Prolonged bleeding time (HP:0003010)1.83537944
119Hyperkalemia (HP:0002153)1.81685483
120Hypoplastic ischia (HP:0003175)1.80314006
121Urinary urgency (HP:0000012)1.80015931
122Agammaglobulinemia (HP:0004432)1.79978735
123Ragged-red muscle fibers (HP:0003200)1.79287673
124Mildly elevated creatine phosphokinase (HP:0008180)1.79249741
125Encephalitis (HP:0002383)1.79163645
126Restrictive lung disease (HP:0002091)1.78503049
127Epistaxis (HP:0000421)1.77521789
128Scapular winging (HP:0003691)1.76915399
129Keratoconjunctivitis (HP:0001096)1.76603401
130Proximal amyotrophy (HP:0007126)1.75908434
131Distal arthrogryposis (HP:0005684)1.74533370
132Achilles tendon contracture (HP:0001771)1.74400937
133Central scotoma (HP:0000603)1.74333273
134Subacute progressive viral hepatitis (HP:0006572)1.73995334
135Polycythemia (HP:0001901)1.73816993
136Cerebral aneurysm (HP:0004944)1.73714575
137Amyloidosis (HP:0011034)1.73574957
138Focal motor seizures (HP:0011153)1.72851340
139Toxemia of pregnancy (HP:0100603)1.72331161
140Progressive muscle weakness (HP:0003323)1.71956988
141Bulbar palsy (HP:0001283)1.71905435
142Cholelithiasis (HP:0001081)1.71200780
143Ulnar deviation of the wrist (HP:0003049)1.70850482
144Verrucae (HP:0200043)1.70800477
145Papilloma (HP:0012740)1.70800477
146Hyperglycemia (HP:0003074)1.70650869
147Abnormality of the Achilles tendon (HP:0005109)1.70360763
148Myopathic facies (HP:0002058)1.69898801
149Myokymia (HP:0002411)1.67103258
150Foot dorsiflexor weakness (HP:0009027)1.65847255
151Lymphangioma (HP:0100764)1.65821120
152Broad metatarsal (HP:0001783)1.64540983
153Round ear (HP:0100830)1.64413345
154Abnormality of the foot musculature (HP:0001436)1.62700075
155Congestive heart failure (HP:0001635)1.61923078
156Athetosis (HP:0002305)1.61865118
157Hyperglycinuria (HP:0003108)1.61699381
158Palmoplantar keratoderma (HP:0000982)1.61234387
159Hypoalphalipoproteinemia (HP:0003233)1.61205993
160Poor eye contact (HP:0000817)1.61043435
161Neuroendocrine neoplasm (HP:0100634)1.60355820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.39804128
2TTN4.37555573
3TRIB33.81376765
4PKN23.19846250
5PHKG22.82961659
6PHKG12.82961659
7PDK42.74013203
8PDK32.74013203
9LMTK22.73827929
10OBSCN2.70556866
11MAP3K142.60509323
12DMPK2.52520017
13NEK12.16745632
14CDK122.05322087
15IRAK41.90477908
16BLK1.85458786
17PINK11.78227761
18KSR21.73724534
19RIPK11.73264385
20PRKD31.71218171
21ZAP701.65921130
22TAOK11.65188295
23PDK21.62106932
24CSK1.60538264
25EPHA41.57895271
26MAP3K71.56124730
27TBK11.51659714
28STK381.51442903
29TAOK21.51082518
30LATS11.48949447
31IRAK31.46858570
32IKBKE1.40234438
33MAP3K91.39049019
34TRPM71.35261275
35BMPR21.34084765
36SIK31.33337987
37PIK3CG1.24919551
38BCKDK1.20957535
39CAMKK11.18896331
40PRKCH1.18564053
41MAP2K41.15878459
42EEF2K1.12999438
43PAK61.10433153
44BTK1.08167013
45BRD41.07348389
46SGK31.07108305
47MAP2K31.06997919
48RET1.06407768
49PDK11.06344543
50MAP3K41.05204807
51SYK1.04838530
52MOS1.04351119
53IRAK11.03607479
54IRAK21.02732986
55PDGFRA1.00716658
56MYLK0.98942541
57FGFR40.97259771
58NTRK30.95357272
59PIK3CA0.95305566
60IKBKB0.93611584
61MARK30.93505070
62FGFR30.93432750
63MAP4K10.92385625
64MAPK70.92201928
65JAK10.92148252
66DAPK20.90090134
67PDPK10.89432703
68LATS20.87828895
69STK100.87469293
70PTK60.86057384
71STK240.85968874
72HIPK20.84997937
73SMG10.83892175
74TXK0.83198374
75MATK0.83058296
76PRKD10.82921507
77PAK30.81961201
78CDK60.81846256
79FES0.80566977
80PRKAA10.79190846
81WNK10.78866945
82CSF1R0.77113533
83MAPK120.77069981
84MAP3K50.75457854
85YES10.75017808
86CAMK1G0.73549893
87ERN10.73000934
88FGR0.72868744
89PRKAA20.72428292
90MAP3K100.71682924
91TYRO30.70780515
92CAMK1D0.68110446
93ALK0.66873614
94CAMK40.66145010
95CHUK0.65731575
96TGFBR20.65187612
97LRRK20.64987781
98SGK20.64835015
99CDK40.63842162
100MAPK110.63674786
101MAP3K110.63547915
102KIT0.63512526
103TYK20.62054582
104LYN0.61772540
105LCK0.61648408
106JAK20.61627031
107PDGFRB0.61014172
108STK110.59650964
109NLK0.59229307
110JAK30.58825312
111MAP3K10.58764672
112MAP3K20.58683498
113RAF10.58571675
114CDC42BPA0.58226085
115KSR10.57541514
116SIK20.57015490
117MAP3K130.55295819
118MUSK0.55277185
119ICK0.53909249
120TEC0.52850731
121RIPK40.51828678
122CAMKK20.51533862
123SGK10.51346982
124EPHB10.51093455
125PTK2B0.50756084
126FLT30.50428157
127SIK10.50237819
128MINK10.49690297
129ROCK10.48964021
130MAPKAPK30.46393742
131ILK0.46208817
132GRK70.45404938
133PIM10.44501220
134ITK0.43683992
135CAMK10.42346127
136MTOR0.41931573
137CAMK2D0.41706832
138NTRK10.41553272
139MAPK40.39876523
140RPS6KC10.39466870
141RPS6KL10.39466870
142RPS6KA30.38491485
143MAP3K30.38094369
144MAP3K60.37037140
145PRKACG0.36631807
146GRK60.36277903
147WNK40.35476704
148STK38L0.35318020
149HCK0.33866925
150NEK90.33851475
151MARK20.33692759

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.01089680
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.57182483
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.13916814
4Leishmaniasis_Homo sapiens_hsa051402.43461577
5Dilated cardiomyopathy_Homo sapiens_hsa054142.36691149
6Nitrogen metabolism_Homo sapiens_hsa009102.24395742
7Propanoate metabolism_Homo sapiens_hsa006402.14787072
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.14457971
9Fatty acid degradation_Homo sapiens_hsa000712.07659667
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04208351
11Acute myeloid leukemia_Homo sapiens_hsa052211.96993027
12Cardiac muscle contraction_Homo sapiens_hsa042601.95743654
13Allograft rejection_Homo sapiens_hsa053301.94512682
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.83802621
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73840260
16Graft-versus-host disease_Homo sapiens_hsa053321.72792453
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70675547
18Carbon metabolism_Homo sapiens_hsa012001.69340392
19Tuberculosis_Homo sapiens_hsa051521.69043424
20Autoimmune thyroid disease_Homo sapiens_hsa053201.65441276
21Influenza A_Homo sapiens_hsa051641.63149299
22Staphylococcus aureus infection_Homo sapiens_hsa051501.61346237
23Measles_Homo sapiens_hsa051621.60721434
24Toxoplasmosis_Homo sapiens_hsa051451.60699751
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60276485
26Arginine biosynthesis_Homo sapiens_hsa002201.58656206
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55603332
28TNF signaling pathway_Homo sapiens_hsa046681.54586206
29Fatty acid metabolism_Homo sapiens_hsa012121.52624773
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46965318
31Asthma_Homo sapiens_hsa053101.45968990
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43994677
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43834281
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43350920
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.43327477
36Pancreatic cancer_Homo sapiens_hsa052121.42929615
37Hepatitis B_Homo sapiens_hsa051611.39391359
38Insulin resistance_Homo sapiens_hsa049311.37133116
39Other glycan degradation_Homo sapiens_hsa005111.36209217
40Herpes simplex infection_Homo sapiens_hsa051681.35556822
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.33718857
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33654189
43Legionellosis_Homo sapiens_hsa051341.32353332
44Glucagon signaling pathway_Homo sapiens_hsa049221.30177476
45Primary immunodeficiency_Homo sapiens_hsa053401.28684406
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.28485166
47Type I diabetes mellitus_Homo sapiens_hsa049401.27747487
48Long-term potentiation_Homo sapiens_hsa047201.26981814
49Malaria_Homo sapiens_hsa051441.26801063
50Oxytocin signaling pathway_Homo sapiens_hsa049211.26498421
51Gastric acid secretion_Homo sapiens_hsa049711.23837304
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21852256
53Olfactory transduction_Homo sapiens_hsa047401.20333686
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19807945
55Hepatitis C_Homo sapiens_hsa051601.19577032
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17737885
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17112024
58Type II diabetes mellitus_Homo sapiens_hsa049301.16899954
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16787860
60Chemokine signaling pathway_Homo sapiens_hsa040621.16024674
61Pyruvate metabolism_Homo sapiens_hsa006201.15897265
62Insulin signaling pathway_Homo sapiens_hsa049101.15831574
63PPAR signaling pathway_Homo sapiens_hsa033201.14452789
64Hematopoietic cell lineage_Homo sapiens_hsa046401.12244587
65Renin secretion_Homo sapiens_hsa049241.11374760
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09567800
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08445696
68Antigen processing and presentation_Homo sapiens_hsa046121.08349730
69Viral myocarditis_Homo sapiens_hsa054161.05174412
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04569066
71Circadian entrainment_Homo sapiens_hsa047131.01985121
72mTOR signaling pathway_Homo sapiens_hsa041501.01869593
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01712350
74Endometrial cancer_Homo sapiens_hsa052131.00596268
75Apoptosis_Homo sapiens_hsa042101.00049931
76Calcium signaling pathway_Homo sapiens_hsa040200.98475344
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.97400474
78Butanoate metabolism_Homo sapiens_hsa006500.96737344
79Insulin secretion_Homo sapiens_hsa049110.94631102
80Biosynthesis of amino acids_Homo sapiens_hsa012300.94122890
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93153435
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92126294
83Salivary secretion_Homo sapiens_hsa049700.91313197
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90802800
85Bile secretion_Homo sapiens_hsa049760.90019297
86Pertussis_Homo sapiens_hsa051330.87946190
87Fatty acid biosynthesis_Homo sapiens_hsa000610.86338144
88cAMP signaling pathway_Homo sapiens_hsa040240.85259568
89Cholinergic synapse_Homo sapiens_hsa047250.84358819
90Dorso-ventral axis formation_Homo sapiens_hsa043200.83996342
91Lysine degradation_Homo sapiens_hsa003100.83882161
92GnRH signaling pathway_Homo sapiens_hsa049120.83880398
93African trypanosomiasis_Homo sapiens_hsa051430.83494031
94VEGF signaling pathway_Homo sapiens_hsa043700.82091875
95Shigellosis_Homo sapiens_hsa051310.81451440
96AMPK signaling pathway_Homo sapiens_hsa041520.81088145
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80835288
98Prostate cancer_Homo sapiens_hsa052150.80501421
99Starch and sucrose metabolism_Homo sapiens_hsa005000.80441345
100ErbB signaling pathway_Homo sapiens_hsa040120.80216217
101Amphetamine addiction_Homo sapiens_hsa050310.80056007
102Thyroid cancer_Homo sapiens_hsa052160.78791958
103Caffeine metabolism_Homo sapiens_hsa002320.78283177
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.77651027
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77600386
106HTLV-I infection_Homo sapiens_hsa051660.77475149
107Epstein-Barr virus infection_Homo sapiens_hsa051690.76030304
108Viral carcinogenesis_Homo sapiens_hsa052030.75231132
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.75000785
110Bladder cancer_Homo sapiens_hsa052190.72953340
111Rheumatoid arthritis_Homo sapiens_hsa053230.72550137
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.71775228
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71084322
114Circadian rhythm_Homo sapiens_hsa047100.70772958
115Dopaminergic synapse_Homo sapiens_hsa047280.70184531
116Salmonella infection_Homo sapiens_hsa051320.70168735
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69968235
118Small cell lung cancer_Homo sapiens_hsa052220.69237415
119Morphine addiction_Homo sapiens_hsa050320.69187874
120Choline metabolism in cancer_Homo sapiens_hsa052310.66841374
121Glioma_Homo sapiens_hsa052140.66188352
122Colorectal cancer_Homo sapiens_hsa052100.66058231
123GABAergic synapse_Homo sapiens_hsa047270.65596567
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65371106
125Estrogen signaling pathway_Homo sapiens_hsa049150.62919621
126Tryptophan metabolism_Homo sapiens_hsa003800.61724280
127HIF-1 signaling pathway_Homo sapiens_hsa040660.61607960
128Glutamatergic synapse_Homo sapiens_hsa047240.60069773
129Non-small cell lung cancer_Homo sapiens_hsa052230.58884743
130Platelet activation_Homo sapiens_hsa046110.58601167
131Phagosome_Homo sapiens_hsa041450.57991553
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56251513
133Focal adhesion_Homo sapiens_hsa045100.55204636
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54548946
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52914123
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.52544753
137Renal cell carcinoma_Homo sapiens_hsa052110.51977490
138Notch signaling pathway_Homo sapiens_hsa043300.49583170
139beta-Alanine metabolism_Homo sapiens_hsa004100.47470346
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47132786
141MAPK signaling pathway_Homo sapiens_hsa040100.47083030
142Gap junction_Homo sapiens_hsa045400.46385428
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.46172581
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45979534
145Cocaine addiction_Homo sapiens_hsa050300.44067573
146Glycerolipid metabolism_Homo sapiens_hsa005610.43503639
147T cell receptor signaling pathway_Homo sapiens_hsa046600.42061609
148Prolactin signaling pathway_Homo sapiens_hsa049170.40985602
149FoxO signaling pathway_Homo sapiens_hsa040680.40128722
150B cell receptor signaling pathway_Homo sapiens_hsa046620.39889968
151Pancreatic secretion_Homo sapiens_hsa049720.39501005
152Amoebiasis_Homo sapiens_hsa051460.39441578
153Inositol phosphate metabolism_Homo sapiens_hsa005620.39331056
154Osteoclast differentiation_Homo sapiens_hsa043800.38104077
155Adherens junction_Homo sapiens_hsa045200.37925290
156Chronic myeloid leukemia_Homo sapiens_hsa052200.37653839
157Proteoglycans in cancer_Homo sapiens_hsa052050.37308062
158Synaptic vesicle cycle_Homo sapiens_hsa047210.35758530

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »