PPWD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.43709561
2ribosomal small subunit biogenesis (GO:0042274)5.31249394
3viral transcription (GO:0019083)5.26826219
4translational termination (GO:0006415)5.07788865
5telomere maintenance via semi-conservative replication (GO:0032201)4.67707701
6ribosomal large subunit biogenesis (GO:0042273)4.62558858
7regulation of histone H3-K27 methylation (GO:0061085)4.62367518
8DNA double-strand break processing (GO:0000729)4.61436554
9maturation of SSU-rRNA (GO:0030490)4.51533334
10DNA replication initiation (GO:0006270)4.49773444
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45662329
12cotranslational protein targeting to membrane (GO:0006613)4.39894616
13cornea development in camera-type eye (GO:0061303)4.39500184
14protein targeting to ER (GO:0045047)4.35820467
15DNA strand elongation involved in DNA replication (GO:0006271)4.28332278
16translational elongation (GO:0006414)4.24846057
17synapsis (GO:0007129)4.20715765
18telomere maintenance via recombination (GO:0000722)4.18724128
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.12400535
20DNA strand elongation (GO:0022616)4.12188938
21protein localization to endoplasmic reticulum (GO:0070972)4.09666793
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98036097
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.94091364
24regulation of mitotic spindle checkpoint (GO:1903504)3.94091364
25mitotic recombination (GO:0006312)3.92561179
26translational initiation (GO:0006413)3.89737063
27cellular protein complex disassembly (GO:0043624)3.89551709
28DNA ligation (GO:0006266)3.87684266
29viral life cycle (GO:0019058)3.86905123
30CENP-A containing nucleosome assembly (GO:0034080)3.72789210
31monoubiquitinated protein deubiquitination (GO:0035520)3.67957253
32chromatin remodeling at centromere (GO:0031055)3.64096839
33replication fork processing (GO:0031297)3.59237506
34ribonucleoprotein complex biogenesis (GO:0022613)3.59056672
35telomere maintenance via telomere lengthening (GO:0010833)3.55425329
36DNA replication checkpoint (GO:0000076)3.48784264
37kinetochore organization (GO:0051383)3.45466530
38protein complex disassembly (GO:0043241)3.43746813
39regulation of timing of cell differentiation (GO:0048505)3.42032542
40centriole replication (GO:0007099)3.41888895
41spindle checkpoint (GO:0031577)3.40387687
42mitotic spindle checkpoint (GO:0071174)3.39233557
43protein K6-linked ubiquitination (GO:0085020)3.37175161
44DNA deamination (GO:0045006)3.34371465
45regulation of double-strand break repair via homologous recombination (GO:0010569)3.33877111
46histone H2A acetylation (GO:0043968)3.33174528
47DNA catabolic process, exonucleolytic (GO:0000738)3.31067646
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.29031624
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.25969739
50negative regulation of sister chromatid segregation (GO:0033046)3.25969739
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25969739
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25969739
53negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25969739
54mitotic metaphase plate congression (GO:0007080)3.23857465
55kinetochore assembly (GO:0051382)3.23693898
56macromolecular complex disassembly (GO:0032984)3.23034693
57prenylation (GO:0097354)3.22200981
58protein prenylation (GO:0018342)3.22200981
59rRNA processing (GO:0006364)3.20422120
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.20070198
61negative regulation of chromosome segregation (GO:0051985)3.16821861
62mRNA catabolic process (GO:0006402)3.14125049
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12624153
64regulation of mitotic sister chromatid segregation (GO:0033047)3.12313056
65regulation of sister chromatid segregation (GO:0033045)3.12313056
66regulation of mitotic sister chromatid separation (GO:0010965)3.12313056
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11235032
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11235032
69mitotic spindle assembly checkpoint (GO:0007094)3.11142191
70rRNA metabolic process (GO:0016072)3.10123272
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09167299
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.09167299
73regulation of translation, ncRNA-mediated (GO:0045974)3.09167299
74DNA replication-independent nucleosome assembly (GO:0006336)3.07518243
75DNA replication-independent nucleosome organization (GO:0034724)3.07518243
76translation (GO:0006412)3.06881793
77spindle assembly checkpoint (GO:0071173)3.06149725
78DNA unwinding involved in DNA replication (GO:0006268)3.05226505
79proteasome assembly (GO:0043248)3.04469493
80termination of RNA polymerase III transcription (GO:0006386)3.03934463
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.03934463
82regulation of development, heterochronic (GO:0040034)3.03610476
83RNA catabolic process (GO:0006401)3.02848390
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01591410
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99123485
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98355389
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96350973
88resolution of meiotic recombination intermediates (GO:0000712)2.96127299
89protein heterotetramerization (GO:0051290)2.92575065
90pseudouridine synthesis (GO:0001522)2.91803558
91metaphase plate congression (GO:0051310)2.91530771
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89930955
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89930955
94isotype switching (GO:0045190)2.89930955
95neural tube formation (GO:0001841)2.88858917
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88129526
97ribosome assembly (GO:0042255)2.87942388
98regulation of chromosome segregation (GO:0051983)2.86462571
99negative regulation of DNA recombination (GO:0045910)2.86222356
100histone exchange (GO:0043486)2.84551423
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82336822
102histone mRNA catabolic process (GO:0071044)2.82157136
103DNA-dependent DNA replication (GO:0006261)2.81795413
104transcription-coupled nucleotide-excision repair (GO:0006283)2.81152726
105mitotic G2/M transition checkpoint (GO:0044818)2.80884163
106sister chromatid segregation (GO:0000819)2.80858244
107interferon-gamma production (GO:0032609)2.80466521
108DNA damage response, detection of DNA damage (GO:0042769)2.80400154
109double-strand break repair via homologous recombination (GO:0000724)2.80326816
110maturation of 5.8S rRNA (GO:0000460)2.80282840
111IMP biosynthetic process (GO:0006188)2.80240447
112mitotic sister chromatid segregation (GO:0000070)2.80164898
113mitotic nuclear envelope disassembly (GO:0007077)2.79707855
114recombinational repair (GO:0000725)2.79349316
115postreplication repair (GO:0006301)2.78587153
116DNA replication-dependent nucleosome organization (GO:0034723)2.78584559
117DNA replication-dependent nucleosome assembly (GO:0006335)2.78584559
118tRNA modification (GO:0006400)2.78542570
119hindbrain development (GO:0030902)2.76885718
120cellular component biogenesis (GO:0044085)2.76436544
121regulation of stem cell maintenance (GO:2000036)2.75764332
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74586910
123nuclear pore complex assembly (GO:0051292)2.73635399
124protein targeting to membrane (GO:0006612)2.71827890
125regulation of centriole replication (GO:0046599)2.70977504
126response to pheromone (GO:0019236)2.70423834
127peptidyl-lysine trimethylation (GO:0018023)2.69153963
128telomere maintenance (GO:0000723)2.68703243
129rRNA methylation (GO:0031167)2.68579174
130telomere organization (GO:0032200)2.67416799
131pre-miRNA processing (GO:0031054)2.67159742
132spliceosomal snRNP assembly (GO:0000387)2.65091877
133mismatch repair (GO:0006298)2.64784073
134generation of neurons (GO:0048699)2.63325970
135regulation of helicase activity (GO:0051095)2.63062700
136double-strand break repair via nonhomologous end joining (GO:0006303)2.62489644
137non-recombinational repair (GO:0000726)2.62489644
138positive regulation of histone H3-K4 methylation (GO:0051571)2.61662699
139histone-serine phosphorylation (GO:0035404)2.61089342
140protein localization to kinetochore (GO:0034501)2.60740196
141exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60315976
142histone mRNA metabolic process (GO:0008334)2.59908941
143spliceosomal complex assembly (GO:0000245)2.59170938
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.57989152
145ncRNA processing (GO:0034470)2.57886397
146establishment of chromosome localization (GO:0051303)2.57732325
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.57480207
148positive regulation of cell fate commitment (GO:0010455)2.57258878
149regulation of meiosis I (GO:0060631)2.57244857
150ribosome biogenesis (GO:0042254)2.57105603
151negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57086284
152negative regulation of ligase activity (GO:0051352)2.57086284
153meiotic chromosome segregation (GO:0045132)2.56841943
154DNA replication (GO:0006260)2.56709589
155dorsal/ventral axis specification (GO:0009950)2.56647823
156response to folic acid (GO:0051593)2.56013752
157termination of RNA polymerase I transcription (GO:0006363)2.54292068
158transcription elongation from RNA polymerase I promoter (GO:0006362)2.52324726
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51748140
160attachment of spindle microtubules to kinetochore (GO:0008608)2.50628433
161DNA-templated transcription, termination (GO:0006353)2.46783927
162regulation of metalloenzyme activity (GO:0048552)2.45882360
163maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45869318
164somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45710708
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.45710708
166cullin deneddylation (GO:0010388)2.44354630
167termination of RNA polymerase II transcription (GO:0006369)2.43209547
1687-methylguanosine mRNA capping (GO:0006370)2.41864862
169intra-S DNA damage checkpoint (GO:0031573)2.41129834
170DNA topological change (GO:0006265)2.40449998
171mitochondrial DNA replication (GO:0006264)2.39964113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.49063292
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.09822647
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87193289
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.85626227
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56488486
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.51423003
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26781159
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.16694034
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.12290869
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99726552
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.99104909
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73199015
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60692740
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59925893
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59252927
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56825611
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47730496
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45710165
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44855525
20* VDR_23849224_ChIP-Seq_CD4+_Human2.41667032
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.40927418
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39406430
23ZNF274_21170338_ChIP-Seq_K562_Hela2.37068437
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32125259
25FUS_26573619_Chip-Seq_HEK293_Human2.30581681
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23714375
27IRF1_19129219_ChIP-ChIP_H3396_Human2.22869165
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20531564
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20442248
30FOXP3_21729870_ChIP-Seq_TREG_Human2.15294391
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14682234
32ELK1_19687146_ChIP-ChIP_HELA_Human2.13739601
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07235096
34VDR_22108803_ChIP-Seq_LS180_Human2.04916026
35XRN2_22483619_ChIP-Seq_HELA_Human1.99469523
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98893126
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91204805
38TAF15_26573619_Chip-Seq_HEK293_Human1.91026473
39* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90567236
40* TTF2_22483619_ChIP-Seq_HELA_Human1.88037287
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.79654247
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75661453
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75514084
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73879614
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71931623
46DCP1A_22483619_ChIP-Seq_HELA_Human1.71843584
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70583697
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64102985
49IGF1R_20145208_ChIP-Seq_DFB_Human1.61877960
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61094494
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60422816
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56777966
53P300_19829295_ChIP-Seq_ESCs_Human1.56546712
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54166699
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53143687
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.51494065
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50326458
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49816979
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49774387
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47492066
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47422771
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.46963646
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46098917
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.44943450
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42448018
66AR_21909140_ChIP-Seq_LNCAP_Human1.40583476
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40492754
68GABP_19822575_ChIP-Seq_HepG2_Human1.38707260
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.36478805
70MYC_18940864_ChIP-ChIP_HL60_Human1.35321463
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35017160
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33126428
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31772393
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.30343452
75SPI1_23547873_ChIP-Seq_NB4_Human1.29018364
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26818716
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26818716
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26818716
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.25811187
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.25420102
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22260359
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19747815
83* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19342310
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17842156
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17647170
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17083960
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16598384
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.16533350
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.13744284
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13726234
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13719233
92CBP_20019798_ChIP-Seq_JUKART_Human1.13719233
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12952932
94ER_23166858_ChIP-Seq_MCF-7_Human1.11518734
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11470478
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11191574
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09656192
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09333134
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09099250
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08533530
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08490917
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08438102
103KDM5A_27292631_Chip-Seq_BREAST_Human1.07905503
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07445075
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06515000
106* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06099112
107SALL4_22934838_ChIP-ChIP_CD34+_Human1.05787273
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03669177
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03235878
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00912095
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00310753
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99601186
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.99563809
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99098175
115CIITA_25753668_ChIP-Seq_RAJI_Human0.98101382
116ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97631800
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.96511355
118* SOX2_19829295_ChIP-Seq_ESCs_Human0.94866650
119* NANOG_19829295_ChIP-Seq_ESCs_Human0.94866650
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94496181
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.94258987
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93012789
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92719819
124TP53_22573176_ChIP-Seq_HFKS_Human0.92481878
125BCAT_22108803_ChIP-Seq_LS180_Human0.91234141
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90725551
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90489487
128P300_18555785_Chip-Seq_ESCs_Mouse0.90342736
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.90014083
130EWS_26573619_Chip-Seq_HEK293_Human0.88736690
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87938221
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87269092
133SMAD4_21799915_ChIP-Seq_A2780_Human0.87130314
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86452595
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85948648
136STAT3_23295773_ChIP-Seq_U87_Human0.85753639
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85211302
138MYB_26560356_Chip-Seq_TH2_Human0.84741085
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83106929
140MYC_22102868_ChIP-Seq_BL_Human0.82201338
141TFEB_21752829_ChIP-Seq_HELA_Human0.80013835
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78829754
143SCL_19346495_ChIP-Seq_HPC-7_Human0.77928147
144SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77861911
145IRF8_21731497_ChIP-ChIP_J774_Mouse0.75734020
146MYB_26560356_Chip-Seq_TH1_Human0.73519208
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72539706
148NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71718796
149FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70958054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.76793122
2MP0010094_abnormal_chromosome_stability3.71569261
3MP0003136_yellow_coat_color3.67324409
4MP0003693_abnormal_embryo_hatching3.63118475
5MP0006292_abnormal_olfactory_placode3.34054363
6MP0002638_abnormal_pupillary_reflex3.27779521
7MP0002009_preneoplasia3.09604787
8MP0008057_abnormal_DNA_replication2.98775756
9MP0008058_abnormal_DNA_repair2.98113694
10MP0008007_abnormal_cellular_replicative2.94130180
11MP0004957_abnormal_blastocyst_morpholog2.85907283
12MP0003787_abnormal_imprinting2.79992859
13MP0003077_abnormal_cell_cycle2.71695383
14MP0003111_abnormal_nucleus_morphology2.57365908
15MP0008789_abnormal_olfactory_epithelium2.51157751
16MP0004381_abnormal_hair_follicle2.40136075
17MP0000566_synostosis2.23208259
18MP0006054_spinal_hemorrhage2.10882845
19MP0001188_hyperpigmentation2.01414906
20MP0005409_darkened_coat_color2.00550513
21MP0005499_abnormal_olfactory_system1.85376768
22MP0005394_taste/olfaction_phenotype1.85376768
23MP0003786_premature_aging1.85248248
24MP0008995_early_reproductive_senescence1.84404237
25MP0008932_abnormal_embryonic_tissue1.83472030
26MP0003763_abnormal_thymus_physiology1.82188799
27MP0003121_genomic_imprinting1.81096278
28MP0002396_abnormal_hematopoietic_system1.78286025
29MP0000490_abnormal_crypts_of1.77080806
30MP0005174_abnormal_tail_pigmentation1.76749899
31MP0003718_maternal_effect1.76190486
32MP0005075_abnormal_melanosome_morpholog1.72048459
33MP0005257_abnormal_intraocular_pressure1.69102358
34MP0009333_abnormal_splenocyte_physiolog1.48993471
35MP0000015_abnormal_ear_pigmentation1.47965053
36MP0002095_abnormal_skin_pigmentation1.47668213
37MP0002132_abnormal_respiratory_system1.45855893
38MP0000613_abnormal_salivary_gland1.43791549
39MP0000372_irregular_coat_pigmentation1.42559582
40MP0008877_abnormal_DNA_methylation1.41771339
41MP0000465_gastrointestinal_hemorrhage1.33186026
42MP0006072_abnormal_retinal_apoptosis1.32940026
43MP0000350_abnormal_cell_proliferation1.32585142
44MP0002398_abnormal_bone_marrow1.31405379
45MP0005671_abnormal_response_to1.29937211
46MP0003567_abnormal_fetal_cardiomyocyte1.28965423
47MP0002166_altered_tumor_susceptibility1.28173781
48MP0002006_tumorigenesis1.26327268
49MP0002938_white_spotting1.26072630
50MP0003724_increased_susceptibility_to1.25485227
51MP0003941_abnormal_skin_development1.23675538
52MP0001800_abnormal_humoral_immune1.21843892
53MP0001835_abnormal_antigen_presentation1.20290643
54MP0003195_calcinosis1.20270227
55MP0005410_abnormal_fertilization1.19858939
56MP0009785_altered_susceptibility_to1.18577720
57MP0002420_abnormal_adaptive_immunity1.17975809
58MP0001819_abnormal_immune_cell1.16245143
59MP0001986_abnormal_taste_sensitivity1.15686815
60MP0002928_abnormal_bile_duct1.13873245
61MP0002148_abnormal_hypersensitivity_rea1.13863531
62MP0002722_abnormal_immune_system1.12775611
63MP0002210_abnormal_sex_determination1.12334992
64MP0002019_abnormal_tumor_incidence1.11583215
65MP0000703_abnormal_thymus_morphology1.11445357
66MP0005000_abnormal_immune_tolerance1.11080766
67MP0003890_abnormal_embryonic-extraembry1.11034260
68MP0000689_abnormal_spleen_morphology1.10865435
69MP0002452_abnormal_antigen_presenting1.10154122
70MP0002177_abnormal_outer_ear1.08500013
71MP0002723_abnormal_immune_serum1.08495553
72MP0005253_abnormal_eye_physiology1.07513391
73MP0000569_abnormal_digit_pigmentation1.06747348
74MP0002277_abnormal_respiratory_mucosa1.06635848
75MP0000716_abnormal_immune_system1.05618120
76MP0000858_altered_metastatic_potential1.05502619
77MP0004808_abnormal_hematopoietic_stem1.04449662
78MP0005025_abnormal_response_to1.04331965
79MP0000647_abnormal_sebaceous_gland1.03466565
80MP0003938_abnormal_ear_development1.02972629
81MP0008260_abnormal_autophagy1.02499376
82MP0002429_abnormal_blood_cell1.00973558
83MP0002160_abnormal_reproductive_system1.00950403
84MP0000383_abnormal_hair_follicle0.97466970
85MP0000313_abnormal_cell_death0.95934966
86MP0001286_abnormal_eye_development0.95890799
87MP0001919_abnormal_reproductive_system0.95657435
88MP0000681_abnormal_thyroid_gland0.94350470
89MP0003315_abnormal_perineum_morphology0.93355191
90MP0001324_abnormal_eye_pigmentation0.92469894
91MP0002249_abnormal_larynx_morphology0.90905545
92MP0001529_abnormal_vocalization0.90648914
93MP0005551_abnormal_eye_electrophysiolog0.90455581
94MP0003698_abnormal_male_reproductive0.90449688
95MP0005084_abnormal_gallbladder_morpholo0.90243490
96MP0003436_decreased_susceptibility_to0.90230265
97MP0001119_abnormal_female_reproductive0.90072598
98MP0003937_abnormal_limbs/digits/tail_de0.89928714
99MP0001145_abnormal_male_reproductive0.89892479
100MP0005389_reproductive_system_phenotype0.86509165
101MP0002138_abnormal_hepatobiliary_system0.86236538
102MP0000049_abnormal_middle_ear0.86152545
103MP0010307_abnormal_tumor_latency0.83290749
104MP0000653_abnormal_sex_gland0.82392677
105MP0003880_abnormal_central_pattern0.82306945
106MP0001929_abnormal_gametogenesis0.82033686
107MP0001661_extended_life_span0.80018130
108MP0001853_heart_inflammation0.79997367
109MP0002102_abnormal_ear_morphology0.79632512
110MP0002419_abnormal_innate_immunity0.79614361
111MP0005391_vision/eye_phenotype0.79205307
112MP0001730_embryonic_growth_arrest0.78532638
113MP0009697_abnormal_copulation0.78241952
114MP0002085_abnormal_embryonic_tissue0.77451501
115MP0000631_abnormal_neuroendocrine_gland0.77392754
116MP0003119_abnormal_digestive_system0.77136682
117MP0003943_abnormal_hepatobiliary_system0.77119118
118MP0001764_abnormal_homeostasis0.76885406
119MP0001697_abnormal_embryo_size0.76377266
120MP0002751_abnormal_autonomic_nervous0.76107940
121MP0002163_abnormal_gland_morphology0.75723407
122MP0005397_hematopoietic_system_phenotyp0.75693914
123MP0001545_abnormal_hematopoietic_system0.75693914
124MP0001790_abnormal_immune_system0.75224422
125MP0005387_immune_system_phenotype0.75224422
126MP0000428_abnormal_craniofacial_morphol0.74888545
127MP0006035_abnormal_mitochondrial_morpho0.74139530
128MP0006036_abnormal_mitochondrial_physio0.74126972
129MP0003221_abnormal_cardiomyocyte_apopto0.74066651
130MP0009703_decreased_birth_body0.73274513
131MP0000427_abnormal_hair_cycle0.72898319
132MP0005408_hypopigmentation0.72487940
133MP0002075_abnormal_coat/hair_pigmentati0.72198690
134MP0004197_abnormal_fetal_growth/weight/0.72150893
135MP0002080_prenatal_lethality0.72082137
136MP0001672_abnormal_embryogenesis/_devel0.71903865
137MP0005380_embryogenesis_phenotype0.71903865
138MP0005310_abnormal_salivary_gland0.71744369
139MP0002084_abnormal_developmental_patter0.71155829
140MP0004147_increased_porphyrin_level0.70365467
141MP0000678_abnormal_parathyroid_gland0.70159354
142MP0003123_paternal_imprinting0.68537509
143MP0001293_anophthalmia0.67824412
144MP0001186_pigmentation_phenotype0.67044671
145MP0003699_abnormal_female_reproductive0.65980337
146MP0002405_respiratory_system_inflammati0.65474435
147MP0010678_abnormal_skin_adnexa0.65134363
148MP0004133_heterotaxia0.62844803

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.10970265
2Hypoplasia of the fovea (HP:0007750)4.53310619
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.53310619
4Abnormality of cells of the erythroid lineage (HP:0012130)4.35009912
5Abnormal number of erythroid precursors (HP:0012131)4.15745700
6Type I transferrin isoform profile (HP:0003642)3.76975611
7Abnormality of the fovea (HP:0000493)3.74584596
8Chromsome breakage (HP:0040012)3.74455771
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71468273
10Macrocytic anemia (HP:0001972)3.60433349
11Birth length less than 3rd percentile (HP:0003561)3.56528153
12Reduced antithrombin III activity (HP:0001976)3.37401618
13Pallor (HP:0000980)3.27845192
14Abnormality of the preputium (HP:0100587)3.21217629
15Meckel diverticulum (HP:0002245)3.20884882
16Abnormality of chromosome stability (HP:0003220)3.14070176
17Abnormality of the ileum (HP:0001549)3.06431196
18Abnormality of the labia minora (HP:0012880)3.06352347
19Aplastic anemia (HP:0001915)3.02248853
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.99159929
21Severe combined immunodeficiency (HP:0004430)2.96307102
22Aplasia/Hypoplasia of the macula (HP:0008059)2.92870419
23Triphalangeal thumb (HP:0001199)2.87315781
24Thyroiditis (HP:0100646)2.78976381
25Absent thumb (HP:0009777)2.78833592
26Clubbing of toes (HP:0100760)2.72946874
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70421929
28Pancreatic cysts (HP:0001737)2.68092514
29Colon cancer (HP:0003003)2.67441551
30Combined immunodeficiency (HP:0005387)2.67189170
31Optic nerve coloboma (HP:0000588)2.67145026
32True hermaphroditism (HP:0010459)2.66571883
33Aplasia/Hypoplasia affecting the retina (HP:0008061)2.65170267
34Supernumerary spleens (HP:0009799)2.62999272
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57741847
3611 pairs of ribs (HP:0000878)2.55956137
37Volvulus (HP:0002580)2.55105842
38Abnormal hemoglobin (HP:0011902)2.55074475
39Breast hypoplasia (HP:0003187)2.54720968
40Abnormal lung lobation (HP:0002101)2.54001336
41Abnormality of the prostate (HP:0008775)2.50432892
42Abnormality of the renal collecting system (HP:0004742)2.49380668
43T lymphocytopenia (HP:0005403)2.48055100
44Abnormal protein glycosylation (HP:0012346)2.46708958
45Abnormal glycosylation (HP:0012345)2.46708958
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46708958
47Abnormal protein N-linked glycosylation (HP:0012347)2.46708958
48Impulsivity (HP:0100710)2.43135489
49Myelodysplasia (HP:0002863)2.42967879
50Asplenia (HP:0001746)2.39896193
51Renal cortical cysts (HP:0000803)2.39492944
52Pancreatic fibrosis (HP:0100732)2.36135138
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36043106
54Duodenal stenosis (HP:0100867)2.33898579
55Small intestinal stenosis (HP:0012848)2.33898579
56IgM deficiency (HP:0002850)2.33432915
57Pancytopenia (HP:0001876)2.30128554
58Microvesicular hepatic steatosis (HP:0001414)2.29907908
59Optic nerve hypoplasia (HP:0000609)2.27619847
60Duplicated collecting system (HP:0000081)2.27550994
61Bone marrow hypocellularity (HP:0005528)2.26931898
623-Methylglutaconic aciduria (HP:0003535)2.25635653
63Intestinal atresia (HP:0011100)2.23824285
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22933776
65Abnormality of T cell number (HP:0011839)2.22011992
66Capillary hemangiomas (HP:0005306)2.19145378
67Molar tooth sign on MRI (HP:0002419)2.18748913
68Abnormality of midbrain morphology (HP:0002418)2.18748913
69Papillary thyroid carcinoma (HP:0002895)2.16798053
70Abnormal rod and cone electroretinograms (HP:0008323)2.15038719
71Patellar aplasia (HP:0006443)2.14134142
72Panhypogammaglobulinemia (HP:0003139)2.11829898
73Biliary tract neoplasm (HP:0100574)2.11466441
74Hypoplasia of the radius (HP:0002984)2.10244988
75Meningitis (HP:0001287)2.09586906
76Cleft eyelid (HP:0000625)2.08618475
77Ectopic kidney (HP:0000086)2.07581023
78Aplasia/Hypoplasia of the spleen (HP:0010451)2.06583038
79Medulloblastoma (HP:0002885)2.06251444
80Nephronophthisis (HP:0000090)2.05164756
81Absent radius (HP:0003974)2.02623577
82Abnormality of the pons (HP:0007361)2.01571239
83Aplasia/Hypoplasia of the patella (HP:0006498)1.99807285
84Abnormality of the heme biosynthetic pathway (HP:0010472)1.98046855
85Abnormality of the renal cortex (HP:0011035)1.97547889
86Abnormal biliary tract physiology (HP:0012439)1.97515662
87Bile duct proliferation (HP:0001408)1.97515662
88Increased hepatocellular lipid droplets (HP:0006565)1.97140452
89Lip pit (HP:0100267)1.96863171
90Abnormality of DNA repair (HP:0003254)1.95301094
91Sloping forehead (HP:0000340)1.94489653
92Hyponatremia (HP:0002902)1.94459586
93Abnormality of the duodenum (HP:0002246)1.93453747
94IgG deficiency (HP:0004315)1.92175417
95Thrombocytosis (HP:0001894)1.91395981
96Abnormality of T cells (HP:0002843)1.91199244
97Abnormality of the septum pellucidum (HP:0007375)1.91116044
98Premature graying of hair (HP:0002216)1.90884755
99Exertional dyspnea (HP:0002875)1.88973382
100Agammaglobulinemia (HP:0004432)1.88499117
101Stenosis of the external auditory canal (HP:0000402)1.88383616
102Nephroblastoma (Wilms tumor) (HP:0002667)1.87208630
103Oligodactyly (hands) (HP:0001180)1.86848897
104Dyschromatopsia (HP:0007641)1.86845001
105Basal cell carcinoma (HP:0002671)1.86413974
106Absent forearm bone (HP:0003953)1.85774543
107Aplasia involving forearm bones (HP:0009822)1.85774543
108Chronic obstructive pulmonary disease (HP:0006510)1.85760469
109Obstructive lung disease (HP:0006536)1.85760469
110Encephalitis (HP:0002383)1.85162921
111Lymphoma (HP:0002665)1.84950628
112Medial flaring of the eyebrow (HP:0010747)1.84539506
113Congenital, generalized hypertrichosis (HP:0004540)1.83944079
114Aqueductal stenosis (HP:0002410)1.83771204
115Stomatitis (HP:0010280)1.83502785
116Hypoplasia of the thymus (HP:0000778)1.83400206
117Methylmalonic acidemia (HP:0002912)1.82915536
118Abnormality of dental color (HP:0011073)1.82796075
119Dry hair (HP:0011359)1.81174256
120Neoplasm of the colon (HP:0100273)1.78829878
121Amelogenesis imperfecta (HP:0000705)1.78542930
122Septo-optic dysplasia (HP:0100842)1.77976446
123Absent septum pellucidum (HP:0001331)1.76111508
124Embryonal renal neoplasm (HP:0011794)1.74751241
125Abnormality of the anterior horn cell (HP:0006802)1.74370102
126Degeneration of anterior horn cells (HP:0002398)1.74370102
127Amaurosis fugax (HP:0100576)1.74167675
128Ovarian neoplasm (HP:0100615)1.73851396
129Hypothermia (HP:0002045)1.73442173
130Renal Fanconi syndrome (HP:0001994)1.73430852
131Elevated erythrocyte sedimentation rate (HP:0003565)1.73055038
132Difficulty running (HP:0009046)1.72868332
133Sex reversal (HP:0012245)1.72571362
134Abnormal sex determination (HP:0012244)1.72571362
135Horseshoe kidney (HP:0000085)1.72073573
136Tracheoesophageal fistula (HP:0002575)1.71491846
137Rhabdomyosarcoma (HP:0002859)1.71370707
138Pancreatic islet-cell hyperplasia (HP:0004510)1.70978509
139Constricted visual fields (HP:0001133)1.70765492
140Pseudobulbar signs (HP:0002200)1.70711273
141Mediastinal lymphadenopathy (HP:0100721)1.70619822
142Abnormality of the columella (HP:0009929)1.69999560
143Selective tooth agenesis (HP:0001592)1.69818420
144Neoplasm of the adrenal cortex (HP:0100641)1.69468235
145Thyroid carcinoma (HP:0002890)1.68405108
146Atresia of the external auditory canal (HP:0000413)1.67872416
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67385137
148Agnosia (HP:0010524)1.67096938
149Chronic mucocutaneous candidiasis (HP:0002728)1.66968366
150Recurrent cutaneous fungal infections (HP:0011370)1.66968366
151Thyroid-stimulating hormone excess (HP:0002925)1.66691665
152Male pseudohermaphroditism (HP:0000037)1.66488820
153Gonadotropin excess (HP:0000837)1.65675228
154Abnormality of the renal medulla (HP:0100957)1.65377287
155Abnormal biliary tract morphology (HP:0012440)1.65292112
156Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64735056
157Broad-based gait (HP:0002136)1.63647209
158Cellular immunodeficiency (HP:0005374)1.63092256
159Abnormal spermatogenesis (HP:0008669)1.62802108
160Neoplasm of the small intestine (HP:0100833)1.62778489
161Ependymoma (HP:0002888)1.62653389
162Acute myeloid leukemia (HP:0004808)1.62153349
163Congenital primary aphakia (HP:0007707)1.61326703
164Chronic hepatic failure (HP:0100626)1.61208937
165Pendular nystagmus (HP:0012043)1.60290666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.09088308
2TLK12.84964777
3EIF2AK32.83691100
4TSSK62.80358396
5FRK2.79071484
6WEE12.69821744
7CLK12.68505139
8CDC72.65239074
9MKNK22.54929813
10NLK2.54455777
11SRPK12.52827588
12NUAK12.45249061
13VRK12.44296447
14PRKD22.44112776
15BUB12.43606378
16MKNK12.33698396
17IRAK42.14427173
18CASK2.10376979
19NEK12.07557587
20TEC2.01894925
21EIF2AK11.98000358
22TNIK1.94695159
23VRK21.85316178
24MAPK131.80487493
25MST41.71724730
26YES11.70467498
27TXK1.64571219
28WNK31.61747885
29EIF2AK21.57693655
30STK161.55035884
31STK381.51798823
32PLK41.46728955
33IRAK31.40219219
34BTK1.34974369
35PTK2B1.34918793
36PIM11.34017102
37CDK71.33817233
38DYRK31.30970209
39MAP4K11.25382062
40TAF11.23419781
41PNCK1.20923339
42BRSK21.19805989
43BRSK11.17020412
44PLK21.14638346
45ACVR1B1.14477920
46PLK11.12481209
47PLK31.10882976
48ZAK1.07744257
49NEK21.06051244
50RPS6KB21.03793155
51AURKB1.03094081
52GRK11.01482434
53TESK21.00973379
54FGFR21.00360799
55TTK1.00235538
56MAP3K140.96429075
57STK38L0.94631492
58STK100.94549964
59PIM20.93652188
60TRIM280.92753982
61BRD40.92305889
62CHEK20.90763080
63STK30.89343655
64PBK0.89171619
65ATR0.86697951
66MUSK0.85018537
67CDK40.82830270
68MAP4K20.82204689
69STK40.82049733
70HIPK20.81276242
71CAMKK20.80300386
72INSRR0.80075681
73IRAK10.79332195
74GRK60.78465884
75BLK0.77652845
76RPS6KA50.76462395
77IKBKB0.74285546
78CCNB10.72350747
79ERBB30.72169300
80AURKA0.72135405
81KIT0.70055097
82PASK0.68657338
83CSNK1G10.66988334
84MAPK150.66873667
85MARK30.66742624
86OXSR10.66379843
87UHMK10.65370421
88LYN0.64287748
89MAPKAPK50.63878395
90CDK60.63040173
91FGFR10.63003896
92RPS6KA40.60153719
93CDK80.59149949
94CSNK2A10.58268073
95CDK30.58197901
96FGR0.54053452
97IKBKE0.52650288
98ATM0.51226669
99BCR0.51009912
100GRK70.49916621
101NME10.49566842
102CSNK2A20.49369570
103MAP3K80.48157109
104MELK0.47265244
105NEK90.46770429
106TRPM70.46423866
107IRAK20.45806463
108CHEK10.45175340
109ALK0.44628486
110BRAF0.43418408
111MAP3K40.43329410
112LCK0.43119916
113AKT30.42729667
114JAK30.41500002
115FLT30.41117106
116PRKCQ0.40958054
117SIK30.40922452
118RPS6KL10.40792678
119RPS6KC10.40792678
120RPS6KA60.40700912
121PAK30.40480140
122ITK0.40434232
123SYK0.40315132
124DYRK20.40292936
125ZAP700.40172683
126STK110.37875034
127BMPR20.37609587
128PDK20.37300835
129TAOK30.37104426
130CDK20.37014337
131ADRBK20.34874727
132CDK190.34613929
133SGK20.33835049
134TGFBR10.33650969
135BMPR1B0.33508898
136MAP2K70.33362475
137STK390.31601276
138MAP3K100.28941315
139FES0.27447736
140NEK60.27192446
141RAF10.27094649
142MAP3K120.26607102

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54153602
2Ribosome_Homo sapiens_hsa030104.48799260
3Mismatch repair_Homo sapiens_hsa034303.46867238
4Homologous recombination_Homo sapiens_hsa034403.22141767
5Spliceosome_Homo sapiens_hsa030403.00356391
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86546904
7RNA polymerase_Homo sapiens_hsa030202.86262814
8Base excision repair_Homo sapiens_hsa034102.83317172
9Fanconi anemia pathway_Homo sapiens_hsa034602.54927480
10Nucleotide excision repair_Homo sapiens_hsa034202.47864094
11Basal transcription factors_Homo sapiens_hsa030222.38200245
12Pyrimidine metabolism_Homo sapiens_hsa002402.32743329
13One carbon pool by folate_Homo sapiens_hsa006702.15859521
14Non-homologous end-joining_Homo sapiens_hsa034502.05765529
15Proteasome_Homo sapiens_hsa030502.05653426
16Cell cycle_Homo sapiens_hsa041102.05515911
17RNA transport_Homo sapiens_hsa030131.97370867
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93438672
19Protein export_Homo sapiens_hsa030601.88269964
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.85941095
21Propanoate metabolism_Homo sapiens_hsa006401.84606866
22RNA degradation_Homo sapiens_hsa030181.69403147
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46105380
24p53 signaling pathway_Homo sapiens_hsa041151.43524545
25Primary immunodeficiency_Homo sapiens_hsa053401.36658149
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35416844
27Antigen processing and presentation_Homo sapiens_hsa046121.26852691
28Herpes simplex infection_Homo sapiens_hsa051681.25392669
29Purine metabolism_Homo sapiens_hsa002301.25113951
30Thyroid cancer_Homo sapiens_hsa052161.21895465
31mRNA surveillance pathway_Homo sapiens_hsa030151.18722364
32Systemic lupus erythematosus_Homo sapiens_hsa053221.18254481
33Graft-versus-host disease_Homo sapiens_hsa053321.10896492
34Measles_Homo sapiens_hsa051621.10562287
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.09232302
36Phototransduction_Homo sapiens_hsa047441.08725392
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07418191
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.03741965
39Epstein-Barr virus infection_Homo sapiens_hsa051691.02643444
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96380220
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93763714
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91464860
43Steroid biosynthesis_Homo sapiens_hsa001000.87249322
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85132320
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.84883358
46Ether lipid metabolism_Homo sapiens_hsa005650.82092064
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80713577
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77030570
49Folate biosynthesis_Homo sapiens_hsa007900.74599696
50Arachidonic acid metabolism_Homo sapiens_hsa005900.73925559
51Allograft rejection_Homo sapiens_hsa053300.73072804
52Pyruvate metabolism_Homo sapiens_hsa006200.72336819
53Type I diabetes mellitus_Homo sapiens_hsa049400.71953246
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.71786532
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71011145
56Butanoate metabolism_Homo sapiens_hsa006500.70542381
57Hematopoietic cell lineage_Homo sapiens_hsa046400.69810901
58Selenocompound metabolism_Homo sapiens_hsa004500.68333759
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68051539
60Viral carcinogenesis_Homo sapiens_hsa052030.65917606
61Asthma_Homo sapiens_hsa053100.65711133
62Autoimmune thyroid disease_Homo sapiens_hsa053200.63844057
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63708374
64Sphingolipid metabolism_Homo sapiens_hsa006000.62870167
65Peroxisome_Homo sapiens_hsa041460.62785997
66Other glycan degradation_Homo sapiens_hsa005110.62670365
67Caffeine metabolism_Homo sapiens_hsa002320.62508498
68TGF-beta signaling pathway_Homo sapiens_hsa043500.62414711
69Olfactory transduction_Homo sapiens_hsa047400.62220254
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61714789
71Sulfur relay system_Homo sapiens_hsa041220.57884930
72Prostate cancer_Homo sapiens_hsa052150.57793617
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57652965
74Alzheimers disease_Homo sapiens_hsa050100.57269574
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56406682
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55170237
77Acute myeloid leukemia_Homo sapiens_hsa052210.55104202
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54144367
79Legionellosis_Homo sapiens_hsa051340.53665664
80Nitrogen metabolism_Homo sapiens_hsa009100.53625205
81Glutathione metabolism_Homo sapiens_hsa004800.52631262
82Huntingtons disease_Homo sapiens_hsa050160.52376468
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52280679
84Basal cell carcinoma_Homo sapiens_hsa052170.50871459
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50859569
86Leishmaniasis_Homo sapiens_hsa051400.50298663
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.50211573
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48819673
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48473281
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48045088
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47234608
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46455528
93Hepatitis B_Homo sapiens_hsa051610.45472409
94Vitamin digestion and absorption_Homo sapiens_hsa049770.45229223
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44850913
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.44397373
97HTLV-I infection_Homo sapiens_hsa051660.43319709
98Taste transduction_Homo sapiens_hsa047420.43266806
99Influenza A_Homo sapiens_hsa051640.42745635
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42595598
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41791785
102MicroRNAs in cancer_Homo sapiens_hsa052060.41393255
103N-Glycan biosynthesis_Homo sapiens_hsa005100.41288960
104Oxidative phosphorylation_Homo sapiens_hsa001900.39543703
105Colorectal cancer_Homo sapiens_hsa052100.38656318
106Vitamin B6 metabolism_Homo sapiens_hsa007500.37554805
107Apoptosis_Homo sapiens_hsa042100.36432552
108Alcoholism_Homo sapiens_hsa050340.35857085
109B cell receptor signaling pathway_Homo sapiens_hsa046620.35471295
110Circadian rhythm_Homo sapiens_hsa047100.35140286
111Wnt signaling pathway_Homo sapiens_hsa043100.34119131
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33960970
113Hedgehog signaling pathway_Homo sapiens_hsa043400.33888259
114Small cell lung cancer_Homo sapiens_hsa052220.32595479
115Linoleic acid metabolism_Homo sapiens_hsa005910.30383877
116Parkinsons disease_Homo sapiens_hsa050120.30159624
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29168492
118Malaria_Homo sapiens_hsa051440.28852800
119Metabolic pathways_Homo sapiens_hsa011000.27188119
120T cell receptor signaling pathway_Homo sapiens_hsa046600.26503949
121Oocyte meiosis_Homo sapiens_hsa041140.25231949
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25147817
123Regulation of autophagy_Homo sapiens_hsa041400.24858381
124Pathways in cancer_Homo sapiens_hsa052000.24704233
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24580891
126Lysine degradation_Homo sapiens_hsa003100.23648360
127Shigellosis_Homo sapiens_hsa051310.22763413
128Pertussis_Homo sapiens_hsa051330.22675541
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22334662
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21795950
131Fatty acid elongation_Homo sapiens_hsa000620.21772589

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