ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cholesterol esterification (GO:0010872)	7.37242169
2	regulation of phospholipase A2 activity (GO:0032429)	7.36056953
3	astrocyte differentiation (GO:0048708)	6.20140181
4	DNA damage induced protein phosphorylation (GO:0006975)	6.18772176
5	epithelial cell fate commitment (GO:0072148)	5.86238238
6	low-density lipoprotein particle remodeling (GO:0034374)	5.43698400
7	dorsal/ventral axis specification (GO:0009950)	5.37066646
8	water-soluble vitamin biosynthetic process (GO:0042364)	5.33232104
9	indolalkylamine metabolic process (GO:0006586)	5.28955325
10	regulation of acrosome reaction (GO:0060046)	5.21398011
11	ubiquinone metabolic process (GO:0006743)	5.15171067
12	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.03446142
13	kidney morphogenesis (GO:0060993)	4.99795523
14	serotonin metabolic process (GO:0042428)	4.96788852
15	regulation of glucocorticoid secretion (GO:2000849)	4.88032245
16	primary amino compound metabolic process (GO:1901160)	4.60316381
17	fucose catabolic process (GO:0019317)	4.54554238
18	L-fucose metabolic process (GO:0042354)	4.54554238
19	L-fucose catabolic process (GO:0042355)	4.54554238
20	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.49948849
21	aldehyde catabolic process (GO:0046185)	4.49419622
22	regulation of autophagic vacuole assembly (GO:2000785)	4.21825238
23	ubiquinone biosynthetic process (GO:0006744)	4.11242189
24	mRNA cleavage (GO:0006379)	4.10956156
25	dopamine transport (GO:0015872)	4.08072467
26	protein-chromophore linkage (GO:0018298)	4.07451372
27	toxin metabolic process (GO:0009404)	4.07228537
28	nonmotile primary cilium assembly (GO:0035058)	3.98035141
29	positive regulation of steroid metabolic process (GO:0045940)	3.94366269
30	regulation of corticosteroid hormone secretion (GO:2000846)	3.91154760
31	digestion (GO:0007586)	3.89106930
32	response to dietary excess (GO:0002021)	3.83584289
33	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.80046782
34	indole-containing compound metabolic process (GO:0042430)	3.79343868
35	insulin secretion (GO:0030073)	3.76090258
36	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	3.66160007
37	early endosome to late endosome transport (GO:0045022)	3.60664609
38	glycerophospholipid catabolic process (GO:0046475)	3.57779319
39	indole-containing compound catabolic process (GO:0042436)	3.55480585
40	indolalkylamine catabolic process (GO:0046218)	3.55480585
41	tryptophan catabolic process (GO:0006569)	3.55480585
42	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.47569748
43	response to corticosterone (GO:0051412)	3.40573202
44	potassium ion import (GO:0010107)	3.38389155
45	response to insecticide (GO:0017085)	3.35633847
46	acylglycerol homeostasis (GO:0055090)	3.33763604
47	triglyceride homeostasis (GO:0070328)	3.33763604
48	quinone biosynthetic process (GO:1901663)	3.32416591
49	pancreas development (GO:0031016)	3.30505362
50	regulation of vacuole organization (GO:0044088)	3.30252621
51	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.27982250
52	negative regulation of circadian rhythm (GO:0042754)	3.27846620
53	dermatan sulfate biosynthetic process (GO:0030208)	3.22165046
54	entrainment of circadian clock by photoperiod (GO:0043153)	3.19186200
55	alkaloid metabolic process (GO:0009820)	3.18359642
56	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.15254079
57	type B pancreatic cell development (GO:0003323)	3.13030066
58	catecholamine transport (GO:0051937)	3.12897433
59	ER overload response (GO:0006983)	3.10891768
60	regulation of heart rate by cardiac conduction (GO:0086091)	3.04065110
61	regulation of Rac protein signal transduction (GO:0035020)	3.03943560
62	membrane repolarization during action potential (GO:0086011)	3.02769642
63	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.00014180
64	behavioral response to nicotine (GO:0035095)	2.98801566
65	brain morphogenesis (GO:0048854)	2.97532946
66	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.95851299
67	substrate-independent telencephalic tangential migration (GO:0021826)	2.95851299
68	axoneme assembly (GO:0035082)	2.95496216
69	protein-lipid complex remodeling (GO:0034368)	2.91773567
70	macromolecular complex remodeling (GO:0034367)	2.91773567
71	plasma lipoprotein particle remodeling (GO:0034369)	2.91773567
72	monoamine transport (GO:0015844)	2.89049825
73	regulation of DNA damage checkpoint (GO:2000001)	2.87746943
74	cardiac conduction (GO:0061337)	2.87411051
75	response to mineralocorticoid (GO:0051385)	2.85103153
76	dopamine biosynthetic process (GO:0042416)	2.84685615
77	regulation of lipoprotein metabolic process (GO:0050746)	2.84356013
78	estrogen biosynthetic process (GO:0006703)	2.82954019
79	dermatan sulfate metabolic process (GO:0030205)	2.82379715
80	photoperiodism (GO:0009648)	2.80444464
81	regulation of steroid hormone secretion (GO:2000831)	2.78819777
82	uronic acid metabolic process (GO:0006063)	2.78379146
83	glucuronate metabolic process (GO:0019585)	2.78379146
84	L-ascorbic acid metabolic process (GO:0019852)	2.77811853
85	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.74345307
86	nephron tubule morphogenesis (GO:0072078)	2.72585409
87	nephron epithelium morphogenesis (GO:0072088)	2.72585409
88	aromatic amino acid family catabolic process (GO:0009074)	2.72309730
89	nodal signaling pathway (GO:0038092)	2.71829782
90	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.71547165
91	muscle hypertrophy in response to stress (GO:0003299)	2.71547165
92	cardiac muscle adaptation (GO:0014887)	2.71547165
93	tryptophan metabolic process (GO:0006568)	2.70981717
94	negative regulation of appetite (GO:0032099)	2.69526676
95	negative regulation of response to food (GO:0032096)	2.69526676
96	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.68907063
97	glandular epithelial cell development (GO:0002068)	2.67839605
98	cornea development in camera-type eye (GO:0061303)	2.67400867
99	induction of positive chemotaxis (GO:0050930)	2.66575979
100	positive regulation of protein homooligomerization (GO:0032464)	2.66509228

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.30573549
2	TAF15_26573619_Chip-Seq_HEK293_Human	4.45908992
3	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.62042719
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30372977
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25355298
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02777657
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92209973
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.91341157
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.83737891
10	GBX2_23144817_ChIP-Seq_PC3_Human	1.68518492
11	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.65904818
12	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.64669990
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.62262772
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.61970535
15	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61256356
16	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.61239651
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59066872
18	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56903163
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.54695513
20	FUS_26573619_Chip-Seq_HEK293_Human	1.53957739
21	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.51028281
22	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.49034384
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48377136
24	PHF8_20622853_ChIP-Seq_HELA_Human	1.47139016
25	VDR_22108803_ChIP-Seq_LS180_Human	1.45839346
26	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.45212049
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41537887
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.39854179
29	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38467476
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38162728
31	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.37052433
32	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.35578893
33	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.34805102
34	AR_25329375_ChIP-Seq_VCAP_Human	1.34471221
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.27054004
36	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23378286
37	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20923541
38	NFYA_21822215_ChIP-Seq_K562_Human	1.20768780
39	STAT3_23295773_ChIP-Seq_U87_Human	1.20437970
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19853306
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19408797
42	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.19379113
43	P300_19829295_ChIP-Seq_ESCs_Human	1.19328343
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.18312650
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17631589
46	ETV1_20927104_ChIP-Seq_GIST48_Human	1.17239466
47	TCF4_23295773_ChIP-Seq_U87_Human	1.17167472
48	NFYB_21822215_ChIP-Seq_K562_Human	1.17154982
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17010508
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16634672
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.15896476
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14975318
53	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.14158625
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12974994
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12860256
56	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.12089250
57	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.11552650
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10823055
59	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.10072588
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09364510
61	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.09003281
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07922001
63	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.05798187
64	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05572918
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05092977
66	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04740668
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04431070
68	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04397987
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04303401
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03415070
71	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02889255
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02250265
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02247738
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01701749
75	TBL1_22424771_ChIP-Seq_293T_Human	1.01612291
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01479903
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01161828
78	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.00865471
79	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.00738330
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99015461
81	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.98954170
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98566446
83	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.98121641
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97528223
85	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.95803165
86	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.95761352
87	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95031279
88	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95026889
89	AR_20517297_ChIP-Seq_VCAP_Human	0.94921727
90	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.93801115
91	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.93300010
92	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.93027281
93	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.92545903
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92128025
95	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.91434446
96	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.91407643
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89634213
98	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89281567
99	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.88872079
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88393265

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	9.48370036
2	MP0002638_abnormal_pupillary_reflex	6.41492765
3	MP0002909_abnormal_adrenal_gland	3.56375763
4	MP0000538_abnormal_urinary_bladder	3.06662063
5	MP0005379_endocrine/exocrine_gland_phen	2.66441070
6	MP0001502_abnormal_circadian_rhythm	2.55984007
7	MP0009046_muscle_twitch	2.46324819
8	MP0005365_abnormal_bile_salt	2.38718902
9	MP0004043_abnormal_pH_regulation	2.34597648
10	MP0003787_abnormal_imprinting	2.27281356
11	MP0001501_abnormal_sleep_pattern	2.20506996
12	MP0002693_abnormal_pancreas_physiology	2.16033486
13	MP0010386_abnormal_urinary_bladder	2.09787034
14	MP0001984_abnormal_olfaction	2.09774769
15	MP0005423_abnormal_somatic_nervous	2.09435100
16	MP0006276_abnormal_autonomic_nervous	2.08803589
17	MP0002876_abnormal_thyroid_physiology	2.08401705
18	MP0001944_abnormal_pancreas_morphology	2.07579075
19	MP0002163_abnormal_gland_morphology	2.04422942
20	MP0008961_abnormal_basal_metabolism	1.78445372
21	MP0009780_abnormal_chondrocyte_physiolo	1.68859136
22	MP0002733_abnormal_thermal_nociception	1.63696371
23	MP0005310_abnormal_salivary_gland	1.62883102
24	MP0001968_abnormal_touch/_nociception	1.62404797
25	MP0010329_abnormal_lipoprotein_level	1.61367005
26	MP0001756_abnormal_urination	1.54953986
27	MP0005085_abnormal_gallbladder_physiolo	1.52888690
28	MP0002837_dystrophic_cardiac_calcinosis	1.50694513
29	MP0005646_abnormal_pituitary_gland	1.50299152
30	MP0004019_abnormal_vitamin_homeostasis	1.50212896
31	MP0000013_abnormal_adipose_tissue	1.48518089
32	MP0005332_abnormal_amino_acid	1.47607897
33	MP0002138_abnormal_hepatobiliary_system	1.43198334
34	MP0002736_abnormal_nociception_after	1.42699418
35	MP0005535_abnormal_body_temperature	1.39110500
36	MP0001970_abnormal_pain_threshold	1.36646473
37	MP0005220_abnormal_exocrine_pancreas	1.35681687
38	MP0002078_abnormal_glucose_homeostasis	1.33362940
39	MP0000383_abnormal_hair_follicle	1.28068837
40	MP0004885_abnormal_endolymph	1.26158796
41	MP0008775_abnormal_heart_ventricle	1.25652944
42	MP0003283_abnormal_digestive_organ	1.24784073
43	MP0004085_abnormal_heartbeat	1.19205014
44	MP0001905_abnormal_dopamine_level	1.15801316
45	MP0005595_abnormal_vascular_smooth	1.15630136
46	MP0002272_abnormal_nervous_system	1.14743909
47	MP0002572_abnormal_emotion/affect_behav	1.13951155
48	MP0002139_abnormal_hepatobiliary_system	1.13554009
49	MP0008877_abnormal_DNA_methylation	1.10412409
50	MP0009745_abnormal_behavioral_response	1.08287796
51	MP0003137_abnormal_impulse_conducting	1.06022426
52	MP0002734_abnormal_mechanical_nocicepti	1.05106001
53	MP0000631_abnormal_neuroendocrine_gland	1.03857907
54	MP0001764_abnormal_homeostasis	1.00716020
55	MP0010678_abnormal_skin_adnexa	1.00014639
56	MP0002254_reproductive_system_inflammat	0.95369483
57	MP0003953_abnormal_hormone_level	0.95081063
58	MP0003646_muscle_fatigue	0.94528582
59	MP0001919_abnormal_reproductive_system	0.93212815
60	MP0005645_abnormal_hypothalamus_physiol	0.92758914
61	MP0001765_abnormal_ion_homeostasis	0.92617474
62	MP0000639_abnormal_adrenal_gland	0.83964465
63	MP0008995_early_reproductive_senescence	0.83851510
64	MP0005394_taste/olfaction_phenotype	0.82764269
65	MP0005499_abnormal_olfactory_system	0.82764269
66	MP0004215_abnormal_myocardial_fiber	0.81612461
67	MP0002557_abnormal_social/conspecific_i	0.80802082
68	MP0002069_abnormal_eating/drinking_beha	0.80747328
69	MP0002064_seizures	0.79656904
70	MP0003195_calcinosis	0.77753037
71	MP0006072_abnormal_retinal_apoptosis	0.77537960
72	MP0004924_abnormal_behavior	0.76701514
73	MP0005386_behavior/neurological_phenoty	0.76701514
74	MP0004145_abnormal_muscle_electrophysio	0.75112976
75	MP0002877_abnormal_melanocyte_morpholog	0.73786650
76	MP0006082_CNS_inflammation	0.73251152
77	MP0003121_genomic_imprinting	0.71502202
78	MP0002118_abnormal_lipid_homeostasis	0.71111713
79	MP0001661_extended_life_span	0.70965457
80	MP0000003_abnormal_adipose_tissue	0.69524505
81	MP0005389_reproductive_system_phenotype	0.67052782
82	MP0002063_abnormal_learning/memory/cond	0.66958979
83	MP0005551_abnormal_eye_electrophysiolog	0.65973277
84	MP0008873_increased_physiological_sensi	0.64007049
85	MP0008875_abnormal_xenobiotic_pharmacok	0.63675768
86	MP0004133_heterotaxia	0.61990445
87	MP0003252_abnormal_bile_duct	0.60887946
88	MP0004270_analgesia	0.60440098
89	MP0009643_abnormal_urine_homeostasis	0.58900810
90	MP0008057_abnormal_DNA_replication	0.58046735
91	MP0005253_abnormal_eye_physiology	0.58014231
92	MP0005620_abnormal_muscle_contractility	0.57908653
93	MP0003635_abnormal_synaptic_transmissio	0.57215069
94	MP0001664_abnormal_digestion	0.57167575
95	MP0000613_abnormal_salivary_gland	0.55449114
96	MP0008872_abnormal_physiological_respon	0.53181134
97	MP0003868_abnormal_feces_composition	0.52947682
98	MP0005448_abnormal_energy_balance	0.51864022
99	MP0003633_abnormal_nervous_system	0.50655483
100	MP0003011_delayed_dark_adaptation	0.50078095

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Facial shape deformation (HP:0011334)	6.86025516
2	Potter facies (HP:0002009)	6.86025516
3	Mitral stenosis (HP:0001718)	4.85549178
4	Limb dystonia (HP:0002451)	4.38643057
5	Widely patent fontanelles and sutures (HP:0004492)	4.20453001
6	Prominent supraorbital ridges (HP:0000336)	4.15510123
7	Arthropathy (HP:0003040)	4.11325917
8	Cerebellar dysplasia (HP:0007033)	3.97914148
9	Type II lissencephaly (HP:0007260)	3.92021626
10	Diastasis recti (HP:0001540)	3.82131438
11	Severe muscular hypotonia (HP:0006829)	3.73483190
12	Mesangial abnormality (HP:0001966)	3.68498084
13	Hyperventilation (HP:0002883)	3.64851246
14	Decreased circulating renin level (HP:0003351)	3.51120476
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.27861082
16	Tongue fasciculations (HP:0001308)	3.25891475
17	Distal arthrogryposis (HP:0005684)	3.25184264
18	Hypoglycemic coma (HP:0001325)	3.14169551
19	Hypothermia (HP:0002045)	3.13370872
20	Abnormality of renal excretion (HP:0011036)	3.11940645
21	Short hallux (HP:0010109)	3.09736469
22	Renal dysplasia (HP:0000110)	3.08137770
23	J-shaped sella turcica (HP:0002680)	3.08052053
24	Large for gestational age (HP:0001520)	3.02878722
25	Round ear (HP:0100830)	2.96984163
26	Vascular calcification (HP:0004934)	2.95608483
27	Hypotension (HP:0002615)	2.92351015
28	Wrist flexion contracture (HP:0001239)	2.84572994
29	Abnormal urine output (HP:0012590)	2.84390842
30	Muscle fibrillation (HP:0010546)	2.82804853
31	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.78785299
32	Renal tubular acidosis (HP:0001947)	2.76919241
33	Medial flaring of the eyebrow (HP:0010747)	2.72751132
34	Proximal tubulopathy (HP:0000114)	2.71977152
35	Reduced antithrombin III activity (HP:0001976)	2.71230904
36	Abnormal cartilage morphology (HP:0002763)	2.65509044
37	Thickened helices (HP:0000391)	2.65502223
38	Abnormality of urine glucose concentration (HP:0011016)	2.57149675
39	Glycosuria (HP:0003076)	2.57149675
40	Cardiovascular calcification (HP:0011915)	2.53496939
41	Hypomagnesemia (HP:0002917)	2.53004543
42	Lissencephaly (HP:0001339)	2.44082171
43	Attenuation of retinal blood vessels (HP:0007843)	2.41124835
44	Exocrine pancreatic insufficiency (HP:0001738)	2.40934920
45	Abnormality of alanine metabolism (HP:0010916)	2.40223950
46	Hyperalaninemia (HP:0003348)	2.40223950
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40223950
48	Renal cortical cysts (HP:0000803)	2.39371127
49	Microretrognathia (HP:0000308)	2.36108161
50	Agitation (HP:0000713)	2.35523831
51	Abnormality of magnesium homeostasis (HP:0004921)	2.33216458
52	Generalized aminoaciduria (HP:0002909)	2.31901347
53	Insulin-resistant diabetes mellitus (HP:0000831)	2.29901090
54	Abnormal pupillary function (HP:0007686)	2.28745997
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.28733955
56	Pancreatic fibrosis (HP:0100732)	2.27472555
57	Ketoacidosis (HP:0001993)	2.26888347
58	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.25595346
59	Hypoplasia of the fovea (HP:0007750)	2.25595346
60	Abnormality of the renal cortex (HP:0011035)	2.19764131
61	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.19134304
62	Abnormality of the femoral head (HP:0003368)	2.15870601
63	Hyperinsulinemic hypoglycemia (HP:0000825)	2.15640819
64	Pancreatic cysts (HP:0001737)	2.14776394
65	Pachygyria (HP:0001302)	2.12472747
66	Difficulty running (HP:0009046)	2.10429650
67	Disproportionate short-trunk short stature (HP:0003521)	2.07182320
68	Nephronophthisis (HP:0000090)	2.06605165
69	Urethral obstruction (HP:0000796)	2.04727760
70	Nephrogenic diabetes insipidus (HP:0009806)	2.02448629
71	Multifactorial inheritance (HP:0001426)	2.02182937
72	Wide cranial sutures (HP:0010537)	1.99737704
73	Type I transferrin isoform profile (HP:0003642)	1.97975212
74	Barrel-shaped chest (HP:0001552)	1.96467129
75	CNS hypomyelination (HP:0003429)	1.94988493
76	Bile duct proliferation (HP:0001408)	1.92385095
77	Abnormal biliary tract physiology (HP:0012439)	1.92385095
78	Congenital primary aphakia (HP:0007707)	1.91016554
79	Metabolic alkalosis (HP:0200114)	1.90765379
80	Thin upper lip vermilion (HP:0000219)	1.88683727
81	Large eyes (HP:0001090)	1.88381110
82	Gait imbalance (HP:0002141)	1.88231922
83	Late onset (HP:0003584)	1.85959363
84	Joint swelling (HP:0001386)	1.85176139
85	Prolonged QT interval (HP:0001657)	1.80805170
86	Abnormality of the renal medulla (HP:0100957)	1.79754221
87	Abnormality of the vitreous humor (HP:0004327)	1.77754081
88	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.75036860
89	Absent epiphyses (HP:0010577)	1.75036860
90	Cardiomegaly (HP:0001640)	1.74977600
91	Limb hypertonia (HP:0002509)	1.73367948
92	Choreoathetosis (HP:0001266)	1.72939247
93	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.72521711
94	Menstrual irregularities (HP:0000858)	1.71731414
95	Abnormal pancreas size (HP:0012094)	1.71073904
96	Abolished electroretinogram (ERG) (HP:0000550)	1.69957279
97	Abnormality of vitamin B metabolism (HP:0004340)	1.68199236
98	Mixed hearing impairment (HP:0000410)	1.67388120
99	Preaxial foot polydactyly (HP:0001841)	1.62632117
100	Hemiparesis (HP:0001269)	1.61993010

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	5.29739043
2	PIK3CG	4.01623948
3	ACVR1B	3.98857998
4	MAP3K6	3.72125186
5	MAP3K4	3.29347120
6	MAP2K7	2.89173105
7	FRK	2.84011643
8	DAPK2	2.82234125
9	PKN2	2.67442481
10	TGFBR1	2.52855412
11	ERN1	2.30718485
12	ZAK	2.25777381
13	MAP2K6	2.20774597
14	PNCK	2.18345694
15	CSNK1G1	2.04848458
16	FLT3	1.94058983
17	CSNK1G3	1.88192896
18	CDK8	1.87608751
19	PHKG1	1.72182383
20	PHKG2	1.72182383
21	TAOK3	1.68913413
22	MAP4K2	1.60639247
23	MAP2K4	1.58364547
24	PDK2	1.54623226
25	IRAK2	1.45384356
26	RET	1.45158272
27	CSNK1G2	1.41679320
28	ADRBK2	1.33168430
29	MUSK	1.25797088
30	SGK2	1.22647482
31	MST4	1.15741153
32	GRK1	1.15361595
33	BMX	1.13749179
34	MAP3K5	1.10035422
35	MAP3K2	1.06037690
36	PAK3	1.02635482
37	LIMK1	1.01710551
38	FGFR2	0.97316295
39	MELK	0.95122326
40	SGK494	0.92742357
41	SGK223	0.92742357
42	AKT3	0.90174844
43	PTK2	0.89066068
44	PRKCE	0.85367561
45	NTRK3	0.82969662
46	TESK1	0.79880071
47	PINK1	0.79035469
48	PIK3CA	0.75263382
49	RPS6KB1	0.74501313
50	CDK9	0.74483170
51	CDK12	0.73111878
52	WNK4	0.72251626
53	PRKCI	0.71072456
54	INSRR	0.67529945
55	STK24	0.66332629
56	CASK	0.65728748
57	GSK3A	0.59996804
58	TAF1	0.57857664
59	PRKAA1	0.57287132
60	IRAK1	0.55167717
61	ITK	0.54990158
62	SGK3	0.53683390
63	SCYL2	0.50072717
64	CAMK1G	0.49859712
65	PDK1	0.48724437
66	FGFR1	0.47299070
67	PRKCH	0.45938366
68	PRKCQ	0.43661140
69	NME1	0.43605314
70	CSNK1A1	0.43432116
71	HIPK2	0.42856609
72	DAPK1	0.42475955
73	MAP3K12	0.41672600
74	MAP2K2	0.41292597
75	PDPK1	0.40653346
76	CAMK2D	0.40409739
77	PDGFRB	0.38432608
78	CSNK1E	0.36762650
79	LMTK2	0.35643544
80	DMPK	0.35380604
81	MAPK15	0.34235257
82	FER	0.33163666
83	PRKD2	0.32743828
84	DAPK3	0.31629465
85	PRKG1	0.31472897
86	PRKG2	0.31460163
87	MAP2K1	0.31260388
88	TLK1	0.30794606
89	RPS6KA2	0.30705745
90	NLK	0.30064997
91	MAP3K7	0.29764903
92	SGK1	0.28956766
93	ROCK1	0.28544222
94	TIE1	0.27917845
95	ERBB3	0.27574749
96	ADRBK1	0.27145559
97	PRKACA	0.26255175
98	PRKCG	0.24904023
99	PBK	0.24782934
100	MKNK2	0.24619647

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.59051604
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.55223544
3	Tryptophan metabolism_Homo sapiens_hsa00380	3.28418517
4	Circadian rhythm_Homo sapiens_hsa04710	2.69881539
5	Renin-angiotensin system_Homo sapiens_hsa04614	2.67372460
6	Cocaine addiction_Homo sapiens_hsa05030	2.46146208
7	Butanoate metabolism_Homo sapiens_hsa00650	2.32815384
8	Folate biosynthesis_Homo sapiens_hsa00790	2.25644573
9	Insulin secretion_Homo sapiens_hsa04911	2.17670428
10	Amphetamine addiction_Homo sapiens_hsa05031	2.13474054
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.13368211
12	Mineral absorption_Homo sapiens_hsa04978	2.07564971
13	Sulfur metabolism_Homo sapiens_hsa00920	2.01615352
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.98158819
15	Serotonergic synapse_Homo sapiens_hsa04726	1.80724549
16	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.74188067
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.66222067
18	Renin secretion_Homo sapiens_hsa04924	1.61591777
19	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.58907428
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.55767009
21	Type II diabetes mellitus_Homo sapiens_hsa04930	1.52557640
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48263766
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.43501509
24	Pancreatic secretion_Homo sapiens_hsa04972	1.39095642
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38006517
26	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.34900814
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.32263041
28	ABC transporters_Homo sapiens_hsa02010	1.24997123
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.22748666
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21697641
31	Propanoate metabolism_Homo sapiens_hsa00640	1.21160569
32	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.19936857
33	Bile secretion_Homo sapiens_hsa04976	1.19161507
34	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.19068620
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.14463864
36	Protein export_Homo sapiens_hsa03060	1.14045177
37	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.13253695
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.11815248
39	Fatty acid degradation_Homo sapiens_hsa00071	1.10898418
40	Caffeine metabolism_Homo sapiens_hsa00232	1.09434859
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.06703376
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.06178039
43	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.05178628
44	Taste transduction_Homo sapiens_hsa04742	1.04869647
45	Salivary secretion_Homo sapiens_hsa04970	1.03978564
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.02679997
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95963160
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93978353
49	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.91466358
50	Circadian entrainment_Homo sapiens_hsa04713	0.88676554
51	Phenylalanine metabolism_Homo sapiens_hsa00360	0.87160321
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79603689
53	Histidine metabolism_Homo sapiens_hsa00340	0.79223260
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.79108847
55	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.78303802
56	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.78274936
57	RNA degradation_Homo sapiens_hsa03018	0.77989562
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76919742
59	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76159183
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72851735
61	Regulation of autophagy_Homo sapiens_hsa04140	0.72838462
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71970238
63	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.71083252
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.70007391
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69590782
66	Basal transcription factors_Homo sapiens_hsa03022	0.66869716
67	Nicotine addiction_Homo sapiens_hsa05033	0.66174393
68	Parkinsons disease_Homo sapiens_hsa05012	0.65492812
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62277238
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.61867841
71	GABAergic synapse_Homo sapiens_hsa04727	0.61348792
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.59287203
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57509619
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.53581555
75	Peroxisome_Homo sapiens_hsa04146	0.51994027
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50720475
77	mTOR signaling pathway_Homo sapiens_hsa04150	0.49958142
78	Olfactory transduction_Homo sapiens_hsa04740	0.48324936
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.47630549
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.47315918
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46356493
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45749235
83	Metabolic pathways_Homo sapiens_hsa01100	0.44947981
84	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.44737524
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44333846
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43127708
87	Phototransduction_Homo sapiens_hsa04744	0.42506717
88	Sulfur relay system_Homo sapiens_hsa04122	0.41000752
89	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.40792707
90	Prion diseases_Homo sapiens_hsa05020	0.39603795
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39263989
92	Gastric acid secretion_Homo sapiens_hsa04971	0.39223078
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37569094
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37415875
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37275863
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36785723
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35455892
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.34259549
99	Cholinergic synapse_Homo sapiens_hsa04725	0.33968837
100	Glucagon signaling pathway_Homo sapiens_hsa04922	0.33165453

PPY2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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