ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.13984745
2	ATP synthesis coupled proton transport (GO:0015986)	4.96664891
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.96664891
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.76220526
5	proteasome assembly (GO:0043248)	4.76065290
6	chaperone-mediated protein transport (GO:0072321)	4.64865939
7	ribosomal small subunit biogenesis (GO:0042274)	4.44166421
8	viral transcription (GO:0019083)	4.41601847
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.37219078
10	protein maturation by protein folding (GO:0022417)	4.32577684
11	rRNA modification (GO:0000154)	4.29714257
12	translational termination (GO:0006415)	4.23288363
13	cullin deneddylation (GO:0010388)	4.18005328
14	protein complex biogenesis (GO:0070271)	4.16789670
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12514614
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12514614
17	NADH dehydrogenase complex assembly (GO:0010257)	4.12514614
18	cotranslational protein targeting to membrane (GO:0006613)	3.99681136
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.95433264
20	protein neddylation (GO:0045116)	3.94052073
21	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.91927592
22	termination of RNA polymerase III transcription (GO:0006386)	3.91927592
23	maturation of 5.8S rRNA (GO:0000460)	3.90662723
24	protein targeting to ER (GO:0045047)	3.89899125
25	DNA deamination (GO:0045006)	3.89628964
26	negative regulation of microtubule polymerization (GO:0031115)	3.83809979
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.83298936
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.81265005
29	protein deneddylation (GO:0000338)	3.78773093
30	protein localization to endoplasmic reticulum (GO:0070972)	3.75208326
31	establishment of integrated proviral latency (GO:0075713)	3.75021173
32	ribosomal small subunit assembly (GO:0000028)	3.74506151
33	GTP biosynthetic process (GO:0006183)	3.73771454
34	respiratory electron transport chain (GO:0022904)	3.71545697
35	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.68591207
36	guanosine-containing compound biosynthetic process (GO:1901070)	3.66515532
37	oxidative phosphorylation (GO:0006119)	3.65322426
38	electron transport chain (GO:0022900)	3.65122158
39	translational elongation (GO:0006414)	3.63561803
40	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.60738859
41	cellular protein complex disassembly (GO:0043624)	3.60730740
42	pseudouridine synthesis (GO:0001522)	3.58912655
43	negative regulation of ligase activity (GO:0051352)	3.55857638
44	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.55857638
45	ribosome assembly (GO:0042255)	3.55432039
46	protein targeting to mitochondrion (GO:0006626)	3.54103769
47	viral life cycle (GO:0019058)	3.53770460
48	positive regulation of ligase activity (GO:0051351)	3.53276600
49	maturation of SSU-rRNA (GO:0030490)	3.48922965
50	establishment of protein localization to mitochondrion (GO:0072655)	3.48375962
51	rRNA methylation (GO:0031167)	3.47105555
52	DNA damage response, detection of DNA damage (GO:0042769)	3.44924628
53	ribosome biogenesis (GO:0042254)	3.41711119
54	7-methylguanosine mRNA capping (GO:0006370)	3.40561863
55	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.40049262
56	translational initiation (GO:0006413)	3.39295069
57	7-methylguanosine RNA capping (GO:0009452)	3.38721764
58	RNA capping (GO:0036260)	3.38721764
59	UTP biosynthetic process (GO:0006228)	3.35988931
60	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.34309296
61	dopamine transport (GO:0015872)	3.31379595
62	translation (GO:0006412)	3.30283638
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.30178361
64	establishment of viral latency (GO:0019043)	3.27512617
65	regulation of cellular amino acid metabolic process (GO:0006521)	3.25533664
66	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.25163879
67	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.24128612
68	regulation of ligase activity (GO:0051340)	3.22622092
69	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.21600199
70	GDP-mannose metabolic process (GO:0019673)	3.19062829
71	negative regulation of protein ubiquitination (GO:0031397)	3.18779198
72	regulation of mitochondrial translation (GO:0070129)	3.16627398
73	protein localization to mitochondrion (GO:0070585)	3.16509240
74	GMP metabolic process (GO:0046037)	3.15001565
75	spliceosomal snRNP assembly (GO:0000387)	3.13937869
76	protein complex disassembly (GO:0043241)	3.13259606
77	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.13078262
78	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.13078262
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.12515453
80	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.12515453
81	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.11182194
82	DNA strand elongation involved in DNA replication (GO:0006271)	3.10503567
83	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.09667010
84	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.09667010
85	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.09667010
86	cellular component biogenesis (GO:0044085)	3.09194797
87	inner mitochondrial membrane organization (GO:0007007)	3.07959256
88	viral mRNA export from host cell nucleus (GO:0046784)	3.07619435
89	negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	3.05390165
90	spliceosomal complex assembly (GO:0000245)	3.05187119
91	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.04981678
92	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.04981678
93	nucleobase-containing small molecule interconversion (GO:0015949)	3.04550240
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04303737
95	peptidyl-arginine omega-N-methylation (GO:0035247)	3.03275032
96	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.02377185
97	macromolecular complex disassembly (GO:0032984)	3.01536059
98	DNA strand elongation (GO:0022616)	3.01491801
99	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.01267662
100	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.00681891
101	L-serine metabolic process (GO:0006563)	3.00453686
102	transcription from mitochondrial promoter (GO:0006390)	3.00261004
103	viral protein processing (GO:0019082)	2.98667363
104	ribosomal large subunit biogenesis (GO:0042273)	2.97730190
105	ribonucleoprotein complex biogenesis (GO:0022613)	2.97645266
106	mitochondrial transport (GO:0006839)	2.96276111
107	proline biosynthetic process (GO:0006561)	2.95556739
108	tRNA aminoacylation for protein translation (GO:0006418)	2.95001461
109	respiratory chain complex IV assembly (GO:0008535)	2.94827124
110	telomere maintenance via semi-conservative replication (GO:0032201)	2.93797091
111	rRNA processing (GO:0006364)	2.90510064
112	positive regulation of cell cycle arrest (GO:0071158)	2.90498004
113	protein targeting to membrane (GO:0006612)	2.85948928
114	amino acid activation (GO:0043038)	2.85908961
115	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.85792040
116	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.85702904
117	formation of translation preinitiation complex (GO:0001731)	2.83553768
118	catecholamine transport (GO:0051937)	2.82610735
119	rRNA metabolic process (GO:0016072)	2.82357327
120	CTP metabolic process (GO:0046036)	2.80797083
121	CTP biosynthetic process (GO:0006241)	2.80797083
122	neuron cell-cell adhesion (GO:0007158)	2.80395966
123	peptidyl-histidine modification (GO:0018202)	2.79909410
124	regulation of cellular amine metabolic process (GO:0033238)	2.76292078
125	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.71254180
126	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.69863145
127	histone arginine methylation (GO:0034969)	2.68774980

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.59875596
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.40682584
3	* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.01291433
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90303260
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.80084314
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.71997172
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.68049080
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.49250692
9	E2F7_22180533_ChIP-Seq_HELA_Human	3.36834660
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.32859555
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.30773878
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.15191934
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.14086781
14	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.80144179
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.79194853
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.59095125
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.58862264
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.51029184
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50188850
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.40589032
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.33695672
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.29908522
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.24924130
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.21605380
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.12211384
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.10572429
27	TTF2_22483619_ChIP-Seq_HELA_Human	2.04251549
28	* FOXP3_21729870_ChIP-Seq_TREG_Human	2.04221137
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.95357604
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.94551714
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94426355
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.85362099
33	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.81112123
34	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.75530598
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.71007992
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.67669202
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64462610
38	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.56365774
39	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.54217716
40	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.52984786
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.52540608
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52342910
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.48349821
44	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.46987801
45	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.46983984
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.42788080
47	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.40813890
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.40369006
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.39861046
50	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.38643057
51	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.37747491
52	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37395215
53	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.36978549
54	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.34040632
55	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.31728090
56	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.31122839
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29706110
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29628425
59	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.28615250
60	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.27617318
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25867682
62	TFEB_21752829_ChIP-Seq_HELA_Human	1.25615356
63	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.25189930
64	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.23692028
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.22346055
66	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22331626
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20367327
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18146432
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15620274
70	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.15497035
71	MYC_22102868_ChIP-Seq_BL_Human	1.15104165
72	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15001950
73	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13617572
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.13594668
75	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.13550644
76	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.12306146
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11832012
78	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.11494381
79	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.11376894
80	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10817765
81	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.10097360
82	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09442089
83	TAF15_26573619_Chip-Seq_HEK293_Human	1.09235142
84	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.08667257
85	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.08213249
86	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.06861924
87	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.05829546
88	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.05297828
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.04376090
90	VDR_21846776_ChIP-Seq_THP-1_Human	1.03983210
91	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.03205264
92	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03082457
93	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02863152
94	IGF1R_20145208_ChIP-Seq_DFB_Human	1.02627349
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.01983850
96	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01261248
97	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.95989216
98	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.95313508
99	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.95150696
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94332262
101	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.94052496
102	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.93944326
103	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.92281374
104	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.91935644
105	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.91863288
106	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.91744458
107	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.91168019
108	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91101137
109	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90761137
110	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.90482783
111	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.90188009
112	GBX2_23144817_ChIP-Seq_PC3_Human	0.89775267
113	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.89701396
114	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89481563
115	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.88827139
116	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.88234611
117	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.87907797
118	ZNF263_19887448_ChIP-Seq_K562_Human	0.86730013
119	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86045945
120	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85504104
121	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.84354362
122	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.82860034
123	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.82347733
124	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.82031049
125	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.81807608
126	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.81583427
127	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.81405680
128	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.81025912
129	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.80367283
130	EWS_26573619_Chip-Seq_HEK293_Human	0.79899600
131	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.79261693
132	KDM5A_27292631_Chip-Seq_BREAST_Human	0.79022558
133	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.78827019
134	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.78387277

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.53526439
2	MP0003880_abnormal_central_pattern	4.16653891
3	MP0001529_abnormal_vocalization	3.22591386
4	MP0003186_abnormal_redox_activity	3.19894547
5	MP0001905_abnormal_dopamine_level	2.71234853
6	MP0005423_abnormal_somatic_nervous	2.64979014
7	MP0004859_abnormal_synaptic_plasticity	2.55381778
8	MP0003122_maternal_imprinting	2.49589899
9	MP0006276_abnormal_autonomic_nervous	2.48781603
10	MP0001986_abnormal_taste_sensitivity	2.44269742
11	MP0002736_abnormal_nociception_after	2.43161924
12	MP0001968_abnormal_touch/_nociception	2.39799316
13	MP0009379_abnormal_foot_pigmentation	2.37118529
14	MP0009745_abnormal_behavioral_response	2.36362617
15	MP0003635_abnormal_synaptic_transmissio	2.36172418
16	MP0002163_abnormal_gland_morphology	2.30831248
17	MP0002064_seizures	2.25119979
18	MP0008007_abnormal_cellular_replicative	2.21399908
19	MP0002572_abnormal_emotion/affect_behav	2.21287938
20	MP0006292_abnormal_olfactory_placode	2.13363425
21	MP0005645_abnormal_hypothalamus_physiol	2.11038813
22	MP0005451_abnormal_body_composition	2.08850814
23	MP0002734_abnormal_mechanical_nocicepti	2.08345526
24	MP0005058_abnormal_lysosome_morphology	2.07455699
25	MP0002272_abnormal_nervous_system	2.04118561
26	MP0004142_abnormal_muscle_tone	1.98559066
27	MP0009046_muscle_twitch	1.97111653
28	MP0002063_abnormal_learning/memory/cond	1.96179623
29	MP0001440_abnormal_grooming_behavior	1.94397738
30	MP0004147_increased_porphyrin_level	1.90386535
31	MP0002735_abnormal_chemical_nociception	1.89881827
32	MP0002184_abnormal_innervation	1.88639382
33	MP0004270_analgesia	1.86352868
34	MP0000358_abnormal_cell_content/	1.83971156
35	MP0001970_abnormal_pain_threshold	1.81512899
36	MP0009840_abnormal_foam_cell	1.76230254
37	MP0002733_abnormal_thermal_nociception	1.74811311
38	MP0002638_abnormal_pupillary_reflex	1.72399927
39	MP0001486_abnormal_startle_reflex	1.67340645
40	MP0000372_irregular_coat_pigmentation	1.65548975
41	MP0001730_embryonic_growth_arrest	1.62072120
42	MP0005379_endocrine/exocrine_gland_phen	1.60165610
43	MP0001188_hyperpigmentation	1.58739238
44	MP0002822_catalepsy	1.58438224
45	MP0000313_abnormal_cell_death	1.56218595
46	MP0001501_abnormal_sleep_pattern	1.54632852
47	MP0006072_abnormal_retinal_apoptosis	1.51833922
48	MP0000778_abnormal_nervous_system	1.50219902
49	MP0000350_abnormal_cell_proliferation	1.50017636
50	MP0002067_abnormal_sensory_capabilities	1.46698592
51	MP0005075_abnormal_melanosome_morpholog	1.45718903
52	MP0001764_abnormal_homeostasis	1.43167634
53	MP0008057_abnormal_DNA_replication	1.41703155
54	MP0002751_abnormal_autonomic_nervous	1.39386382
55	MP0001984_abnormal_olfaction	1.37854316
56	MP0001727_abnormal_embryo_implantation	1.36262825
57	MP0003315_abnormal_perineum_morphology	1.35342703
58	MP0003121_genomic_imprinting	1.33853324
59	MP0002557_abnormal_social/conspecific_i	1.33470542
60	MP0004742_abnormal_vestibular_system	1.32469153
61	MP0003693_abnormal_embryo_hatching	1.29749868
62	MP0004924_abnormal_behavior	1.27479683
63	MP0005386_behavior/neurological_phenoty	1.27479683
64	MP0003011_delayed_dark_adaptation	1.25835489
65	MP0002837_dystrophic_cardiac_calcinosis	1.25722364
66	MP0010030_abnormal_orbit_morphology	1.24809403
67	MP0000631_abnormal_neuroendocrine_gland	1.23194917
68	MP0002132_abnormal_respiratory_system	1.22582554
69	MP0008789_abnormal_olfactory_epithelium	1.21102358
70	MP0001853_heart_inflammation	1.18785017
71	MP0002080_prenatal_lethality	1.18270157
72	MP0004811_abnormal_neuron_physiology	1.10761970
73	MP0005499_abnormal_olfactory_system	1.10346766
74	MP0005394_taste/olfaction_phenotype	1.10346766
75	MP0002210_abnormal_sex_determination	1.09717835
76	MP0004957_abnormal_blastocyst_morpholog	1.09583397
77	MP0003656_abnormal_erythrocyte_physiolo	1.08911163
78	MP0006035_abnormal_mitochondrial_morpho	1.08881455
79	MP0003879_abnormal_hair_cell	1.08413098
80	MP0002102_abnormal_ear_morphology	1.07935796
81	MP0005330_cardiomyopathy	1.07320609
82	MP0003763_abnormal_thymus_physiology	1.07238100
83	MP0008058_abnormal_DNA_repair	1.06342069
84	MP0005501_abnormal_skin_physiology	1.06261858
85	MP0002019_abnormal_tumor_incidence	1.05816660
86	MP0002066_abnormal_motor_capabilities/c	1.04179655
87	MP0009278_abnormal_bone_marrow	1.03525176
88	MP0008872_abnormal_physiological_respon	1.03242863
89	MP0008260_abnormal_autophagy	1.01904826
90	MP0003221_abnormal_cardiomyocyte_apopto	1.01433736
91	MP0002882_abnormal_neuron_morphology	1.01334392
92	MP0005551_abnormal_eye_electrophysiolog	1.00901382
93	MP0001697_abnormal_embryo_size	1.00713641
94	MP0010094_abnormal_chromosome_stability	1.00491506
95	MP0002752_abnormal_somatic_nervous	0.98819538
96	MP0008877_abnormal_DNA_methylation	0.98474252
97	MP0003786_premature_aging	0.98048079
98	MP0002139_abnormal_hepatobiliary_system	0.97731882
99	MP0005671_abnormal_response_to	0.97023883
100	MP0002938_white_spotting	0.97003104
101	MP0005332_abnormal_amino_acid	0.96996315
102	MP0000955_abnormal_spinal_cord	0.95034526
103	MP0000490_abnormal_crypts_of	0.94783111
104	MP0005646_abnormal_pituitary_gland	0.94392695
105	MP0001502_abnormal_circadian_rhythm	0.93703247
106	MP0005084_abnormal_gallbladder_morpholo	0.93542956
107	MP0000678_abnormal_parathyroid_gland	0.93362631
108	MP0006036_abnormal_mitochondrial_physio	0.92876905
109	MP0008932_abnormal_embryonic_tissue	0.92766398
110	MP0008569_lethality_at_weaning	0.91167767
111	MP0005409_darkened_coat_color	0.91098744
112	MP0005636_abnormal_mineral_homeostasis	0.88310762
113	MP0001929_abnormal_gametogenesis	0.87628567
114	MP0000750_abnormal_muscle_regeneration	0.87574580
115	MP0003077_abnormal_cell_cycle	0.86839952
116	MP0003191_abnormal_cellular_cholesterol	0.86641281
117	MP0003938_abnormal_ear_development	0.84577414
118	MP0001145_abnormal_male_reproductive	0.84297849
119	MP0003787_abnormal_imprinting	0.83956478
120	MP0001963_abnormal_hearing_physiology	0.83387971
121	MP0005253_abnormal_eye_physiology	0.83068103
122	MP0005083_abnormal_biliary_tract	0.81715352
123	MP0003123_paternal_imprinting	0.80606697
124	MP0003567_abnormal_fetal_cardiomyocyte	0.80248311
125	MP0001672_abnormal_embryogenesis/_devel	0.80071926
126	MP0005380_embryogenesis_phenotype	0.80071926
127	MP0002152_abnormal_brain_morphology	0.78553059
128	MP0005171_absent_coat_pigmentation	0.78529627
129	MP0001664_abnormal_digestion	0.78262462
130	MP0000026_abnormal_inner_ear	0.78222791
131	MP0002876_abnormal_thyroid_physiology	0.76846883
132	MP0005408_hypopigmentation	0.76597590
133	MP0002095_abnormal_skin_pigmentation	0.75504298
134	MP0003718_maternal_effect	0.74079718
135	MP0001243_abnormal_dermal_layer	0.73233661
136	MP0000653_abnormal_sex_gland	0.73013549
137	MP0008873_increased_physiological_sensi	0.72154515
138	MP0000703_abnormal_thymus_morphology	0.72001375
139	MP0009672_abnormal_birth_weight	0.70910060
140	MP0002090_abnormal_vision	0.70091952
141	MP0002229_neurodegeneration	0.70046111
142	MP0005266_abnormal_metabolism	0.69954008
143	MP0001545_abnormal_hematopoietic_system	0.69761367
144	MP0005397_hematopoietic_system_phenotyp	0.69761367
145	MP0002277_abnormal_respiratory_mucosa	0.69605459
146	MP0010386_abnormal_urinary_bladder	0.68893807
147	MP0009333_abnormal_splenocyte_physiolog	0.68575693
148	MP0002396_abnormal_hematopoietic_system	0.67386519
149	MP0002069_abnormal_eating/drinking_beha	0.67065507
150	MP0005584_abnormal_enzyme/coenzyme_acti	0.66883629
151	MP0004233_abnormal_muscle_weight	0.66800293
152	MP0003111_abnormal_nucleus_morphology	0.66614098
153	MP0001919_abnormal_reproductive_system	0.66236557
154	MP0000015_abnormal_ear_pigmentation	0.66220720
155	MP0005384_cellular_phenotype	0.66003168
156	MP0002877_abnormal_melanocyte_morpholog	0.65584316
157	MP0002398_abnormal_bone_marrow	0.63758300
158	MP0008995_early_reproductive_senescence	0.63639357
159	MP0003984_embryonic_growth_retardation	0.63238052
160	MP0002796_impaired_skin_barrier	0.62988942
161	MP0003136_yellow_coat_color	0.62057099
162	MP0002148_abnormal_hypersensitivity_rea	0.58559128
163	MP0002088_abnormal_embryonic_growth/wei	0.58216529
164	MP0002161_abnormal_fertility/fecundity	0.57831274
165	MP0001881_abnormal_mammary_gland	0.57662557
166	MP0005319_abnormal_enzyme/_coenzyme	0.57399950
167	MP0002429_abnormal_blood_cell	0.57164805
168	MP0000343_altered_response_to	0.57130676
169	MP0003698_abnormal_male_reproductive	0.57067652
170	MP0002085_abnormal_embryonic_tissue	0.56753965

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.09647766
2	Mitochondrial inheritance (HP:0001427)	4.90821688
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.66788403
4	Increased hepatocellular lipid droplets (HP:0006565)	4.30902137
5	Hepatocellular necrosis (HP:0001404)	4.26250750
6	Progressive macrocephaly (HP:0004481)	4.08064491
7	Increased CSF lactate (HP:0002490)	4.05596000
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.94494452
9	Renal Fanconi syndrome (HP:0001994)	3.81505049
10	Focal motor seizures (HP:0011153)	3.79244636
11	Cerebral hypomyelination (HP:0006808)	3.78343130
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.77570711
13	Acute encephalopathy (HP:0006846)	3.72835014
14	Abnormal number of erythroid precursors (HP:0012131)	3.67352281
15	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.50982212
16	Lipid accumulation in hepatocytes (HP:0006561)	3.48349169
17	Cholecystitis (HP:0001082)	3.32730840
18	Abnormal gallbladder physiology (HP:0012438)	3.32730840
19	Microvesicular hepatic steatosis (HP:0001414)	3.24395758
20	Oral leukoplakia (HP:0002745)	3.21688514
21	Exertional dyspnea (HP:0002875)	3.17169532
22	3-Methylglutaconic aciduria (HP:0003535)	3.16201971
23	Increased intramyocellular lipid droplets (HP:0012240)	3.14566900
24	Increased serum pyruvate (HP:0003542)	3.13386663
25	Abnormality of glycolysis (HP:0004366)	3.13386663
26	Hepatic necrosis (HP:0002605)	3.07644939
27	Myokymia (HP:0002411)	2.93563278
28	Limb dystonia (HP:0002451)	2.91300274
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.89505528
30	Increased serum lactate (HP:0002151)	2.87735651
31	Exercise intolerance (HP:0003546)	2.79088377
32	Respiratory difficulties (HP:0002880)	2.71587519
33	Atonic seizures (HP:0010819)	2.68122151
34	Delusions (HP:0000746)	2.66511053
35	Optic disc pallor (HP:0000543)	2.65968504
36	Abnormal hair whorl (HP:0010721)	2.65299418
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.63777357
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.63777357
39	Multiple enchondromatosis (HP:0005701)	2.62513060
40	Leukodystrophy (HP:0002415)	2.62111436
41	Degeneration of anterior horn cells (HP:0002398)	2.61741783
42	Abnormality of the anterior horn cell (HP:0006802)	2.61741783
43	Abnormal trabecular bone morphology (HP:0100671)	2.60135801
44	Emotional lability (HP:0000712)	2.59057218
45	Hypothermia (HP:0002045)	2.57007129
46	Gait imbalance (HP:0002141)	2.56664816
47	Pancytopenia (HP:0001876)	2.54502548
48	Abnormal pupillary function (HP:0007686)	2.54246700
49	Lethargy (HP:0001254)	2.50068352
50	Abnormality of lateral ventricle (HP:0030047)	2.49171342
51	Macrocytic anemia (HP:0001972)	2.49098543
52	Reticulocytopenia (HP:0001896)	2.48840055
53	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.45986216
54	Lactic acidosis (HP:0003128)	2.43503063
55	Respiratory failure (HP:0002878)	2.41128480
56	Abnormality of the labia minora (HP:0012880)	2.39790150
57	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.39563051
58	Visual hallucinations (HP:0002367)	2.38492968
59	Medial flaring of the eyebrow (HP:0010747)	2.37341626
60	Abnormal autonomic nervous system physiology (HP:0012332)	2.35410263
61	Pallor (HP:0000980)	2.34933549
62	Esotropia (HP:0000565)	2.32204006
63	Congenital primary aphakia (HP:0007707)	2.31958383
64	CNS hypomyelination (HP:0003429)	2.30895830
65	Severe visual impairment (HP:0001141)	2.30828919
66	Progressive muscle weakness (HP:0003323)	2.29369219
67	Abnormality of renal resorption (HP:0011038)	2.29072926
68	Spastic paraparesis (HP:0002313)	2.29068490
69	Nephrogenic diabetes insipidus (HP:0009806)	2.28241213
70	Increased muscle lipid content (HP:0009058)	2.25566174
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.23793697
72	Abnormal protein N-linked glycosylation (HP:0012347)	2.23793697
73	Abnormal protein glycosylation (HP:0012346)	2.23793697
74	Abnormal glycosylation (HP:0012345)	2.23793697
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22331270
76	Ragged-red muscle fibers (HP:0003200)	2.17170505
77	Sparse eyelashes (HP:0000653)	2.15867313
78	Generalized aminoaciduria (HP:0002909)	2.14829566
79	Epileptic encephalopathy (HP:0200134)	2.14218706
80	Secondary amenorrhea (HP:0000869)	2.13684701
81	Reduced antithrombin III activity (HP:0001976)	2.13292587
82	Polyphagia (HP:0002591)	2.11773282
83	Testicular atrophy (HP:0000029)	2.11360412
84	Hypoglycemic coma (HP:0001325)	2.10385002
85	Muscle fiber atrophy (HP:0100295)	2.06043190
86	Focal seizures (HP:0007359)	2.05052946
87	Dicarboxylic aciduria (HP:0003215)	2.04295648
88	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.04295648
89	* Poor suck (HP:0002033)	2.04235957
90	Absence seizures (HP:0002121)	2.03809093
91	Gliosis (HP:0002171)	2.03712139
92	Death in infancy (HP:0001522)	2.01241551
93	Abnormality of reticulocytes (HP:0004312)	2.00469008
94	Abnormal rod and cone electroretinograms (HP:0008323)	1.98153136
95	Type 2 muscle fiber atrophy (HP:0003554)	1.96537500
96	Hyperventilation (HP:0002883)	1.96310783
97	Microretrognathia (HP:0000308)	1.96059291
98	Upper limb muscle weakness (HP:0003484)	1.94967966
99	Nausea (HP:0002018)	1.92837831
100	Progressive microcephaly (HP:0000253)	1.90645896
101	Methylmalonic aciduria (HP:0012120)	1.90427030
102	Congenital stationary night blindness (HP:0007642)	1.89332532
103	Heterochromia iridis (HP:0001100)	1.89140467
104	IgM deficiency (HP:0002850)	1.88975959
105	Broad distal phalanx of finger (HP:0009836)	1.88945799
106	Aplastic anemia (HP:0001915)	1.88889537
107	Cerebral edema (HP:0002181)	1.87339279
108	Amyotrophic lateral sclerosis (HP:0007354)	1.87339061
109	Absent thumb (HP:0009777)	1.86967854
110	CNS demyelination (HP:0007305)	1.86743898
111	Type I transferrin isoform profile (HP:0003642)	1.86393660
112	Neuroendocrine neoplasm (HP:0100634)	1.86083324
113	IgG deficiency (HP:0004315)	1.85973669
114	Dialeptic seizures (HP:0011146)	1.85822859
115	Opisthotonus (HP:0002179)	1.82855746
116	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.82708779
117	Horseshoe kidney (HP:0000085)	1.82028811
118	Broad-based gait (HP:0002136)	1.80497869
119	Premature ovarian failure (HP:0008209)	1.80065313
120	Lissencephaly (HP:0001339)	1.78804887
121	Febrile seizures (HP:0002373)	1.78781611
122	Increased IgM level (HP:0003496)	1.77030589
123	Dysautonomia (HP:0002459)	1.75541197
124	X-linked dominant inheritance (HP:0001423)	1.74830905
125	Vomiting (HP:0002013)	1.73593501
126	Orthostatic hypotension (HP:0001278)	1.72976886
127	Hypokinesia (HP:0002375)	1.72871329
128	Agammaglobulinemia (HP:0004432)	1.72748992
129	Cholelithiasis (HP:0001081)	1.72437797
130	Trismus (HP:0000211)	1.72381897
131	* Blindness (HP:0000618)	1.71889529
132	Glycosuria (HP:0003076)	1.71820776
133	Abnormality of urine glucose concentration (HP:0011016)	1.71820776
134	Seborrheic dermatitis (HP:0001051)	1.71070701
135	Abnormality of methionine metabolism (HP:0010901)	1.69753708
136	Parakeratosis (HP:0001036)	1.68522600
137	Unsteady gait (HP:0002317)	1.67434548
138	Vaginal atresia (HP:0000148)	1.66392238
139	Vacuolated lymphocytes (HP:0001922)	1.65431255
140	Birth length less than 3rd percentile (HP:0003561)	1.64545875
141	Carpal bone hypoplasia (HP:0001498)	1.64087051
142	Premature graying of hair (HP:0002216)	1.63398278
143	Cellular immunodeficiency (HP:0005374)	1.62633946
144	Pheochromocytoma (HP:0002666)	1.61903124
145	Aplasia/hypoplasia of the uterus (HP:0008684)	1.61484787
146	Postnatal microcephaly (HP:0005484)	1.61461479
147	Gout (HP:0001997)	1.61325198
148	Abnormal gallbladder morphology (HP:0012437)	1.61123949
149	Panhypogammaglobulinemia (HP:0003139)	1.60942723
150	Genital tract atresia (HP:0001827)	1.59528337
151	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.58470756
152	Chronic sinusitis (HP:0011109)	1.58325203
153	Rough bone trabeculation (HP:0100670)	1.58014788
154	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.56967568
155	B lymphocytopenia (HP:0010976)	1.56783908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.40282764
2	BUB1	4.23148175
3	STK16	4.11069097
4	NME1	3.26896680
5	CASK	3.22205493
6	MAP3K12	3.13826352
7	PBK	2.70403805
8	SIK3	2.52253341
9	PDK2	2.34977563
10	TESK1	2.19710470
11	TSSK6	2.16368431
12	IRAK3	2.11265394
13	CDK19	1.99794822
14	PNCK	1.98150067
15	MARK1	1.92066431
16	ARAF	1.89082526
17	TESK2	1.87323499
18	CCNB1	1.86561294
19	DYRK2	1.84303256
20	NEK1	1.83339805
21	UHMK1	1.78122080
22	VRK1	1.72623391
23	NME2	1.72068592
24	BCKDK	1.72020994
25	EIF2AK1	1.68580548
26	GRK6	1.62014310
27	TRIM28	1.61976683
28	MAP2K7	1.61783068
29	NTRK3	1.60533681
30	MAPK13	1.52017397
31	TTK	1.50631775
32	PASK	1.50488784
33	MUSK	1.46149486
34	PIM2	1.43992201
35	GRK5	1.42491035
36	ZAK	1.36966708
37	DAPK1	1.32303951
38	MKNK1	1.32146163
39	SMG1	1.31737637
40	SIK2	1.29170223
41	SRPK1	1.27610240
42	EIF2AK3	1.24895221
43	TNIK	1.22886394
44	LRRK2	1.22030609
45	BRSK1	1.21376341
46	BCR	1.15965558
47	ADRBK2	1.12917234
48	CDK8	1.12160959
49	MKNK2	1.11861779
50	NTRK2	1.10464712
51	SYK	1.09998322
52	TAOK2	1.09243678
53	MAP4K1	1.07349366
54	BRAF	1.06090327
55	WEE1	1.05785587
56	TXK	1.05304087
57	PLK1	1.03393357
58	AURKB	1.01444962
59	CSNK1G3	0.99334527
60	PAK4	0.99238702
61	NUAK1	0.98188417
62	PLK2	0.97021498
63	MAPKAPK5	0.94804528
64	MINK1	0.92585282
65	CAMK2B	0.91517427
66	PLK4	0.89127090
67	DYRK1A	0.88653324
68	GRK7	0.87570212
69	STK4	0.86739274
70	ABL2	0.82877516
71	LIMK1	0.82868528
72	MAP3K4	0.82791926
73	PRKD3	0.82616419
74	KDR	0.81987203
75	FES	0.81848231
76	BLK	0.81347648
77	CDK11A	0.81228972
78	ATR	0.81149929
79	CDK18	0.81067019
80	IRAK2	0.80429791
81	BMPR1B	0.79684127
82	CHEK2	0.79133152
83	AURKA	0.78500986
84	EPHA4	0.78224255
85	MYLK	0.75417205
86	CDK15	0.74737213
87	ALK	0.74498760
88	CDK14	0.69770539
89	TLK1	0.69528982
90	MAP3K11	0.68534672
91	TBK1	0.68279990
92	MAP3K8	0.68133567
93	CDK7	0.67797467
94	FGR	0.67582322
95	DYRK3	0.66482949
96	PRKCG	0.64952831
97	PLK3	0.64140782
98	PRKCI	0.63781598
99	EPHA2	0.63753964
100	TGFBR1	0.63584150
101	CHEK1	0.63397252
102	WNK3	0.62588634
103	MAPK4	0.61601794
104	ADRBK1	0.60194222
105	CAMK2A	0.58458335
106	MST4	0.57805970
107	RPS6KB2	0.57728035
108	AKT2	0.56299984
109	YES1	0.55486127
110	ILK	0.55039125
111	RPS6KA4	0.54952433
112	CSNK2A2	0.54719331
113	RPS6KA5	0.54120769
114	MAP4K2	0.53242850
115	PRPF4B	0.53161458
116	CDK5	0.52344577
117	CSNK1G2	0.51888872
118	RAF1	0.51456231
119	OXSR1	0.51436348
120	LYN	0.50638123
121	TNK2	0.50581158
122	ZAP70	0.49588221
123	IKBKB	0.48599836
124	ACVR1B	0.47940164
125	CSNK1G1	0.46911824
126	CAMK2G	0.46749068
127	BTK	0.46675658
128	DAPK2	0.45264459
129	CSF1R	0.44980626
130	DAPK3	0.44896155
131	CDK3	0.44026312
132	CSNK2A1	0.43808683
133	AKT3	0.42853342
134	MAPKAPK3	0.42368110
135	STK10	0.40228365
136	EIF2AK2	0.39252475
137	CLK1	0.39195604
138	CDC7	0.39123555
139	MATK	0.38951278
140	CSNK1A1L	0.38758181
141	PAK1	0.38358838
142	MAPK15	0.38339289
143	PHKG1	0.38183629
144	PHKG2	0.38183629
145	MARK3	0.38150608
146	MAP3K3	0.36774153
147	CDK2	0.36467596
148	LMTK2	0.35055612
149	CDK1	0.33171803
150	BMX	0.32394931
151	MAP2K2	0.32332306

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.36745546
2	Proteasome_Homo sapiens_hsa03050	4.17952552
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.07122827
4	Parkinsons disease_Homo sapiens_hsa05012	3.57015001
5	RNA polymerase_Homo sapiens_hsa03020	3.53096250
6	Alzheimers disease_Homo sapiens_hsa05010	2.67614181
7	Protein export_Homo sapiens_hsa03060	2.60625614
8	Huntingtons disease_Homo sapiens_hsa05016	2.52857963
9	* Spliceosome_Homo sapiens_hsa03040	2.40870850
10	Nicotine addiction_Homo sapiens_hsa05033	2.37493602
11	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.19400402
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.09396868
13	DNA replication_Homo sapiens_hsa03030	2.04970958
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.96323915
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.95733239
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.88936601
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87672831
18	Mismatch repair_Homo sapiens_hsa03430	1.85290970
19	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.82039899
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.71329665
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59297655
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.58057331
23	Carbon metabolism_Homo sapiens_hsa01200	1.53606102
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.51991881
25	RNA transport_Homo sapiens_hsa03013	1.43359491
26	Phototransduction_Homo sapiens_hsa04744	1.42650733
27	Vibrio cholerae infection_Homo sapiens_hsa05110	1.41503584
28	Base excision repair_Homo sapiens_hsa03410	1.41428921
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.39468346
30	Glutathione metabolism_Homo sapiens_hsa00480	1.38830981
31	GABAergic synapse_Homo sapiens_hsa04727	1.32507283
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30982312
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27325026
34	Purine metabolism_Homo sapiens_hsa00230	1.26367625
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24995318
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24856472
37	Serotonergic synapse_Homo sapiens_hsa04726	1.24729659
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.24015340
39	One carbon pool by folate_Homo sapiens_hsa00670	1.23388661
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.21573271
41	Pentose phosphate pathway_Homo sapiens_hsa00030	1.20701956
42	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.19864776
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15752596
44	Taste transduction_Homo sapiens_hsa04742	1.14842306
45	Morphine addiction_Homo sapiens_hsa05032	1.14678085
46	RNA degradation_Homo sapiens_hsa03018	1.12564977
47	Homologous recombination_Homo sapiens_hsa03440	1.11931004
48	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.10717626
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08231702
50	Regulation of autophagy_Homo sapiens_hsa04140	1.03693493
51	Basal transcription factors_Homo sapiens_hsa03022	1.01148272
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93132399
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93071744
54	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.90328868
55	Galactose metabolism_Homo sapiens_hsa00052	0.89089868
56	Amphetamine addiction_Homo sapiens_hsa05031	0.85383856
57	Olfactory transduction_Homo sapiens_hsa04740	0.84018375
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.83944373
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.83375828
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.82473602
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80962921
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.80505551
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.79977491
64	Circadian entrainment_Homo sapiens_hsa04713	0.78585164
65	Other glycan degradation_Homo sapiens_hsa00511	0.75974092
66	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.74818705
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74534277
68	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73658989
69	Alcoholism_Homo sapiens_hsa05034	0.72546460
70	Sulfur metabolism_Homo sapiens_hsa00920	0.71141860
71	Cocaine addiction_Homo sapiens_hsa05030	0.70574822
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66566039
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65382639
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.64797988
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63958136
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.63496451
77	Cell cycle_Homo sapiens_hsa04110	0.62494054
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61250618
79	Long-term potentiation_Homo sapiens_hsa04720	0.60374212
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.59364050
81	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.59230013
82	Fanconi anemia pathway_Homo sapiens_hsa03460	0.57920039
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54644700
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54603180
85	Long-term depression_Homo sapiens_hsa04730	0.54346357
86	Phagosome_Homo sapiens_hsa04145	0.54299614
87	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52085535
88	Cholinergic synapse_Homo sapiens_hsa04725	0.50789102
89	Propanoate metabolism_Homo sapiens_hsa00640	0.49746070
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.49727613
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49694498
92	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.49099309
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.49013364
94	Peroxisome_Homo sapiens_hsa04146	0.48862188
95	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.48031430
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.42257128
97	Oocyte meiosis_Homo sapiens_hsa04114	0.40265203
98	Metabolic pathways_Homo sapiens_hsa01100	0.39635755
99	Gap junction_Homo sapiens_hsa04540	0.39105109
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38872754
101	Legionellosis_Homo sapiens_hsa05134	0.38673324
102	African trypanosomiasis_Homo sapiens_hsa05143	0.38615688
103	Phenylalanine metabolism_Homo sapiens_hsa00360	0.38335816
104	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38225901
105	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36983806
106	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34436478
107	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34425602
108	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33946490
109	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33097917
110	Sulfur relay system_Homo sapiens_hsa04122	0.32761119
111	Butanoate metabolism_Homo sapiens_hsa00650	0.32589916
112	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.32483527
113	Salivary secretion_Homo sapiens_hsa04970	0.32471453
114	Fatty acid elongation_Homo sapiens_hsa00062	0.31948140
115	p53 signaling pathway_Homo sapiens_hsa04115	0.31651822
116	Insulin secretion_Homo sapiens_hsa04911	0.31007206
117	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.30831638
118	Allograft rejection_Homo sapiens_hsa05330	0.30664355
119	Shigellosis_Homo sapiens_hsa05131	0.28281790
120	Herpes simplex infection_Homo sapiens_hsa05168	0.28078754
121	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.27139047
122	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.24940027
123	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24791441
124	Axon guidance_Homo sapiens_hsa04360	0.24662872
125	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.24606635
126	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.24227123
127	Renin secretion_Homo sapiens_hsa04924	0.23975313
128	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.23755721
129	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22672081
130	Asthma_Homo sapiens_hsa05310	0.21870135
131	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.21568289
132	Graft-versus-host disease_Homo sapiens_hsa05332	0.21102538
133	Gastric acid secretion_Homo sapiens_hsa04971	0.20811027
134	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.18286207
135	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.17627276
136	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.17166118
137	Selenocompound metabolism_Homo sapiens_hsa00450	0.17114921
138	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.16721391
139	Folate biosynthesis_Homo sapiens_hsa00790	0.16409901
140	Lysosome_Homo sapiens_hsa04142	0.16354851
141	Antigen processing and presentation_Homo sapiens_hsa04612	0.15846766
142	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.15297889
143	Tryptophan metabolism_Homo sapiens_hsa00380	0.13854059
144	Tyrosine metabolism_Homo sapiens_hsa00350	0.13414287
145	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.13233034
146	Apoptosis_Homo sapiens_hsa04210	0.08864316
147	Viral carcinogenesis_Homo sapiens_hsa05203	0.08840810
148	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.07970811

PQBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »