PQLC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol esterification (GO:0010872)5.17285409
2glycosphingolipid catabolic process (GO:0046479)5.15386058
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.05665283
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.00091954
5L-phenylalanine catabolic process (GO:0006559)5.00091954
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.77934346
7L-phenylalanine metabolic process (GO:0006558)4.77934346
8amino sugar catabolic process (GO:0046348)4.70091879
9oligosaccharide catabolic process (GO:0009313)4.65960768
10glycolipid catabolic process (GO:0019377)4.64707466
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.58793527
12aromatic amino acid family catabolic process (GO:0009074)4.46387650
13indole-containing compound catabolic process (GO:0042436)4.35486183
14indolalkylamine catabolic process (GO:0046218)4.35486183
15tryptophan catabolic process (GO:0006569)4.35486183
16ceramide catabolic process (GO:0046514)4.29091635
17low-density lipoprotein particle remodeling (GO:0034374)4.20371492
18tryptophan metabolic process (GO:0006568)4.18090980
19high-density lipoprotein particle remodeling (GO:0034375)4.15973904
20phospholipid efflux (GO:0033700)4.12234207
21reverse cholesterol transport (GO:0043691)4.04061004
22aldehyde catabolic process (GO:0046185)4.02817491
23sphingolipid catabolic process (GO:0030149)4.00804028
24ATP hydrolysis coupled proton transport (GO:0015991)3.96737357
25energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.96737357
26folic acid transport (GO:0015884)3.90304243
27membrane lipid catabolic process (GO:0046466)3.89694821
28transferrin transport (GO:0033572)3.86021671
29phagosome maturation (GO:0090382)3.82901411
30bile acid biosynthetic process (GO:0006699)3.80407227
31metallo-sulfur cluster assembly (GO:0031163)3.79282546
32iron-sulfur cluster assembly (GO:0016226)3.79282546
33kynurenine metabolic process (GO:0070189)3.78733458
34cholesterol efflux (GO:0033344)3.72848571
35glyoxylate metabolic process (GO:0046487)3.63077758
36plasma lipoprotein particle remodeling (GO:0034369)3.61190239
37protein-lipid complex remodeling (GO:0034368)3.61190239
38macromolecular complex remodeling (GO:0034367)3.61190239
39protein carboxylation (GO:0018214)3.59331164
40peptidyl-glutamic acid carboxylation (GO:0017187)3.59331164
41proteasome assembly (GO:0043248)3.58909213
42positive regulation of lipoprotein lipase activity (GO:0051006)3.56771650
43positive regulation of triglyceride lipase activity (GO:0061365)3.56771650
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56238263
45cofactor catabolic process (GO:0051187)3.47895500
46regulation of protein activation cascade (GO:2000257)3.47369604
47cellular biogenic amine catabolic process (GO:0042402)3.46858288
48amine catabolic process (GO:0009310)3.46858288
49protein insertion into membrane (GO:0051205)3.46046483
50trivalent inorganic cation transport (GO:0072512)3.41892947
51ferric iron transport (GO:0015682)3.41892947
52barbed-end actin filament capping (GO:0051016)3.39885790
53serine transport (GO:0032329)3.39391743
54plasma lipoprotein particle clearance (GO:0034381)3.39257219
55sulfur amino acid catabolic process (GO:0000098)3.38213982
56amino acid salvage (GO:0043102)3.37880541
57L-methionine salvage (GO:0071267)3.37880541
58L-methionine biosynthetic process (GO:0071265)3.37880541
59phospholipid homeostasis (GO:0055091)3.35048195
60negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.34245541
61aromatic amino acid family metabolic process (GO:0009072)3.34046649
62pentose metabolic process (GO:0019321)3.33120615
63negative regulation of mitochondrion organization (GO:0010823)3.33109446
64response to acidic pH (GO:0010447)3.29573035
65regulation of complement activation (GO:0030449)3.29114031
66regulation of cholesterol storage (GO:0010885)3.28408524
67urea metabolic process (GO:0019627)3.27237541
68urea cycle (GO:0000050)3.27237541
69NAD biosynthetic process (GO:0009435)3.24727145
70neutrophil activation involved in immune response (GO:0002283)3.21708994
71negative regulation of mast cell activation (GO:0033004)3.21605599
72nitrogen cycle metabolic process (GO:0071941)3.20123238
73alpha-linolenic acid metabolic process (GO:0036109)3.18917067
74negative regulation of fibrinolysis (GO:0051918)3.18573251
75lytic vacuole organization (GO:0080171)3.13345924
76lysosome organization (GO:0007040)3.13345924
77positive regulation of mitochondrial fission (GO:0090141)3.11710198
78bile acid metabolic process (GO:0008206)3.09679144
79positive regulation of interferon-alpha production (GO:0032727)3.08798462
80protein localization to endosome (GO:0036010)3.08748742
81protein maturation by protein folding (GO:0022417)3.05152297
82base-excision repair, AP site formation (GO:0006285)3.05099863
83ganglioside metabolic process (GO:0001573)3.05072925
84adhesion of symbiont to host cell (GO:0044650)3.00299776
85virion attachment to host cell (GO:0019062)3.00299776
86adhesion of symbiont to host (GO:0044406)2.99150851
87GDP-mannose metabolic process (GO:0019673)2.98458767
88L-ascorbic acid metabolic process (GO:0019852)2.98409181
89complement activation, classical pathway (GO:0006958)2.97676960
90amyloid precursor protein catabolic process (GO:0042987)2.95217729
91negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.95191348
92* basic amino acid transport (GO:0015802)2.94950730
93regulation of interferon-alpha production (GO:0032647)2.94673013
94Golgi transport vesicle coating (GO:0048200)2.93607566
95COPI coating of Golgi vesicle (GO:0048205)2.93607566
96urate metabolic process (GO:0046415)2.93540144
97cellular response to arsenic-containing substance (GO:0071243)2.92470349
98indolalkylamine metabolic process (GO:0006586)2.92334092
99plasma lipoprotein particle assembly (GO:0034377)2.89572254
100negative regulation of myeloid cell apoptotic process (GO:0033033)2.88120052
101complement activation, alternative pathway (GO:0006957)2.87320328
102cellular iron ion homeostasis (GO:0006879)2.86789817
103positive regulation of coagulation (GO:0050820)2.85870839
104glucose 6-phosphate metabolic process (GO:0051156)2.85795827
105serine family amino acid catabolic process (GO:0009071)2.85706706
106regulation of cholesterol metabolic process (GO:0090181)2.85003892
107plasma lipoprotein particle organization (GO:0071827)2.84097423
108regulation of B cell receptor signaling pathway (GO:0050855)2.84011211
109protein retention in ER lumen (GO:0006621)2.83970245
110positive regulation of lymphocyte apoptotic process (GO:0070230)2.82933512
111response to peptidoglycan (GO:0032494)2.82762717
112complement activation (GO:0006956)2.82492820
113positive regulation of blood coagulation (GO:0030194)2.82462723
114positive regulation of hemostasis (GO:1900048)2.82462723
115regulation of fibrinolysis (GO:0051917)2.81406304
116NIK/NF-kappaB signaling (GO:0038061)2.81140684
117L-alpha-amino acid transmembrane transport (GO:1902475)2.80969366
118N-acetylneuraminate metabolic process (GO:0006054)2.80926051
119sulfur amino acid biosynthetic process (GO:0000097)2.79830804
120regulation of interferon-beta biosynthetic process (GO:0045357)2.79528931
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78436212
122glycine metabolic process (GO:0006544)2.77602021
123low-density lipoprotein particle clearance (GO:0034383)2.76834994
124mannose metabolic process (GO:0006013)2.76305317
125glycosphingolipid metabolic process (GO:0006687)2.75910986
126nucleotide salvage (GO:0043173)2.74935594
127regulation of integrin-mediated signaling pathway (GO:2001044)2.74773088
128cysteine metabolic process (GO:0006534)2.74673235
129tyrosine metabolic process (GO:0006570)2.74560179
130arginine metabolic process (GO:0006525)2.73698420
131iron ion transport (GO:0006826)2.73550165
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73520714
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.73520714
134modulation by symbiont of host immune response (GO:0052553)2.73520714
135positive regulation by symbiont of host defense response (GO:0052509)2.73520714
136modulation by symbiont of host defense response (GO:0052031)2.73520714
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73520714
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72902598
139pH reduction (GO:0045851)2.72320082
140pyridine nucleotide biosynthetic process (GO:0019363)2.72034507
141nicotinamide nucleotide biosynthetic process (GO:0019359)2.72034507
142lipoprotein metabolic process (GO:0042157)2.71249126
143regulation of cholesterol biosynthetic process (GO:0045540)2.71221424
144serine family amino acid biosynthetic process (GO:0009070)2.70985125
145protein-lipid complex subunit organization (GO:0071825)2.70331767
146alpha-amino acid catabolic process (GO:1901606)2.70167041
147acylglycerol homeostasis (GO:0055090)2.69378486
148triglyceride homeostasis (GO:0070328)2.69378486
149polyamine biosynthetic process (GO:0006596)2.67009542
150negative regulation of interleukin-12 production (GO:0032695)2.66994632
151L-serine transport (GO:0015825)2.65495362
152protein-lipid complex assembly (GO:0065005)2.65256421
153positive regulation of triglyceride biosynthetic process (GO:0010867)2.65156503
154negative regulation of cholesterol transport (GO:0032375)2.65148782
155negative regulation of sterol transport (GO:0032372)2.65148782
156amino-acid betaine metabolic process (GO:0006577)2.64665519
157homocysteine metabolic process (GO:0050667)2.64569689
158glycoside metabolic process (GO:0016137)2.64182197
159glycerophospholipid catabolic process (GO:0046475)2.64127474
160pyrimidine-containing compound salvage (GO:0008655)2.63752525
161pyrimidine nucleoside salvage (GO:0043097)2.63752525
162regulation of release of cytochrome c from mitochondria (GO:0090199)2.63716336
163regulation of mononuclear cell migration (GO:0071675)2.63309250
164protein activation cascade (GO:0072376)2.62458153
165viral protein processing (GO:0019082)2.62392813
166endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.60061266
167positive regulation of protein homooligomerization (GO:0032464)2.59936173
168decidualization (GO:0046697)2.59558889
169hyaluronan catabolic process (GO:0030214)2.58403786
170glycosylceramide metabolic process (GO:0006677)2.57952764
171response to pH (GO:0009268)2.56361909
172glial cell migration (GO:0008347)2.55387188
173regulation of superoxide anion generation (GO:0032928)2.55155236
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54632900
175intracellular pH reduction (GO:0051452)2.51595709
176oligosaccharide metabolic process (GO:0009311)2.51118741
177deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50322592
178carbohydrate phosphorylation (GO:0046835)2.48544382
179virion assembly (GO:0019068)2.47833032
180response to xenobiotic stimulus (GO:0009410)2.47177076
181cellular transition metal ion homeostasis (GO:0046916)2.46657850
182positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.46197066
183response to thyroid hormone (GO:0097066)2.44318302
184glucose catabolic process (GO:0006007)2.43129877
185regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.43009970
186sphingosine metabolic process (GO:0006670)2.42701791
187dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.42404266
188regulation of mitochondrial fission (GO:0090140)2.41661227
189proline biosynthetic process (GO:0006561)2.40781565
190positive regulation of TOR signaling (GO:0032008)2.40460955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.16381609
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.47055615
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.05302331
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.94676131
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.78631027
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.75517282
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.46968157
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.42461093
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.30381765
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.29868506
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95117530
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.84569018
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51843810
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46156255
15* LXR_22292898_ChIP-Seq_THP-1_Human2.40462032
16* VDR_21846776_ChIP-Seq_THP-1_Human2.23311014
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18020249
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.12308884
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12093841
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.10849450
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09633665
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.07568666
23* ELK3_25401928_ChIP-Seq_HUVEC_Human2.06882869
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06449781
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00278567
26* SRF_21415370_ChIP-Seq_HL-1_Mouse1.96806585
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96668852
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92312018
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85326106
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84790141
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82790501
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.78355222
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77687222
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74623580
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72365986
36* TET1_21451524_ChIP-Seq_MESCs_Mouse1.72272280
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71936049
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71634838
39ZNF263_19887448_ChIP-Seq_K562_Human1.69952182
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66894296
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.62318593
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58820406
43P68_20966046_ChIP-Seq_HELA_Human1.57678512
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56091710
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56037938
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52673350
47CTCF_18555785_ChIP-Seq_MESCs_Mouse1.52577344
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51451081
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51203979
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47447314
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47392808
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.43956442
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.40632282
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.40610336
55TFEB_21752829_ChIP-Seq_HELA_Human1.38665306
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37978026
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36317581
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36288125
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.34480037
60XRN2_22483619_ChIP-Seq_HELA_Human1.32413776
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30036891
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29524842
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29131117
64* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26917179
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26793675
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26645129
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25854233
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25782982
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25265405
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23636558
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23568056
72PHF8_20622854_ChIP-Seq_HELA_Human1.21564236
73* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20888215
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19697600
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18444905
76SA1_27219007_Chip-Seq_Bcells_Human1.18420545
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18186362
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18114609
79* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17999634
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17579303
81TP53_22127205_ChIP-Seq_IMR90_Human1.16593131
82SPI1_23547873_ChIP-Seq_NB4_Human1.16234219
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16118311
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15305083
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15252125
86* VDR_23849224_ChIP-Seq_CD4+_Human1.15184368
87NCOR1_26117541_ChIP-Seq_K562_Human1.13863099
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13378193
89RARB_24833708_ChIP-Seq_LIVER_Mouse1.13318489
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12842918
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12734603
92E2F1_20622854_ChIP-Seq_HELA_Human1.12534712
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11336255
94* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11293144
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11159682
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10596452
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09849701
98* FOXP1_21924763_ChIP-Seq_HESCs_Human1.09283637
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09197342
100* CTCF_20526341_ChIP-Seq_ESCs_Human1.08066227
101VDR_24763502_ChIP-Seq_THP-1_Human1.07376551
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06826582
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06108385
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05319231
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.03276786
106* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02947864
107DCP1A_22483619_ChIP-Seq_HELA_Human1.02794645
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02584599
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02541741
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01998119
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01530829
112KDM5A_27292631_Chip-Seq_BREAST_Human1.01189416
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01047590
114GABP_19822575_ChIP-Seq_HepG2_Human0.99346136
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98403348
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98324436
117THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96253800
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94780246
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.93011071
120* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91982393
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91569716
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91467783
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91032913
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90902334
125FOXP3_21729870_ChIP-Seq_TREG_Human0.89729559
126RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89642143
127GATA1_22025678_ChIP-Seq_K562_Human0.89285013
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88054457
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.87643812
130BCOR_27268052_Chip-Seq_Bcells_Human0.86442502
131* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84887564
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84298411
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84148868
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83528846
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82913636
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82464418
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.82430232
138* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82254657
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80773888
140CLOCK_20551151_ChIP-Seq_293T_Human0.80596383
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80259333
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.79751614
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.79627281
144BCL6_27268052_Chip-Seq_Bcells_Human0.79393733
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78753566
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77575828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell6.01033352
2MP0005360_urolithiasis4.64874242
3MP0002139_abnormal_hepatobiliary_system4.60594451
4MP0005085_abnormal_gallbladder_physiolo3.54376124
5MP0005058_abnormal_lysosome_morphology3.24567974
6MP0003191_abnormal_cellular_cholesterol3.11227412
7MP0005365_abnormal_bile_salt3.05670081
8MP0003806_abnormal_nucleotide_metabolis3.02227504
9MP0005332_abnormal_amino_acid2.67524567
10MP0009278_abnormal_bone_marrow2.37208789
11MP0008875_abnormal_xenobiotic_pharmacok2.34416433
12MP0006054_spinal_hemorrhage2.30658074
13MP0001835_abnormal_antigen_presentation2.28748575
14MP0005451_abnormal_body_composition2.14189713
15MP0004019_abnormal_vitamin_homeostasis2.11553447
16MP0010329_abnormal_lipoprotein_level2.09815914
17MP0005083_abnormal_biliary_tract2.02363653
18MP0003303_peritoneal_inflammation2.01834419
19MP0005167_abnormal_blood-brain_barrier1.95822814
20MP0003195_calcinosis1.95729967
21MP0001542_abnormal_bone_strength1.95535908
22MP0006082_CNS_inflammation1.93308962
23MP0003186_abnormal_redox_activity1.91960987
24MP0000604_amyloidosis1.91173061
25MP0001790_abnormal_immune_system1.90376175
26MP0005387_immune_system_phenotype1.90376175
27MP0003252_abnormal_bile_duct1.85432426
28MP0001545_abnormal_hematopoietic_system1.80083310
29MP0005397_hematopoietic_system_phenotyp1.80083310
30MP0008260_abnormal_autophagy1.79481065
31MP0002419_abnormal_innate_immunity1.79173864
32MP0003436_decreased_susceptibility_to1.78580201
33MP0003075_altered_response_to1.76925265
34MP0010368_abnormal_lymphatic_system1.75868048
35MP0001666_abnormal_nutrient_absorption1.68006379
36MP0004883_abnormal_blood_vessel1.64367324
37MP0002254_reproductive_system_inflammat1.64263668
38MP0000609_abnormal_liver_physiology1.61735404
39MP0001853_heart_inflammation1.57705108
40MP0009697_abnormal_copulation1.55602938
41MP0002148_abnormal_hypersensitivity_rea1.53602190
42MP0009764_decreased_sensitivity_to1.51021659
43MP0001764_abnormal_homeostasis1.50635960
44MP0004510_myositis1.47960802
45MP0005319_abnormal_enzyme/_coenzyme1.45984862
46MP0008469_abnormal_protein_level1.42223260
47MP0009643_abnormal_urine_homeostasis1.40491390
48MP0005000_abnormal_immune_tolerance1.40394220
49MP0004858_abnormal_nervous_system1.40245030
50MP0002138_abnormal_hepatobiliary_system1.39502318
51MP0002653_abnormal_ependyma_morphology1.37892493
52MP0001800_abnormal_humoral_immune1.34910197
53MP0002452_abnormal_antigen_presenting1.33710491
54MP0005464_abnormal_platelet_physiology1.33605704
55MP0001727_abnormal_embryo_implantation1.32785630
56MP0000358_abnormal_cell_content/1.31737935
57MP0005671_abnormal_response_to1.30887629
58MP0004782_abnormal_surfactant_physiolog1.30854207
59MP0002118_abnormal_lipid_homeostasis1.29012325
60MP0002723_abnormal_immune_serum1.26264647
61MP0001958_emphysema1.22460711
62MP0000858_altered_metastatic_potential1.21092974
63MP0002090_abnormal_vision1.20123818
64MP0001845_abnormal_inflammatory_respons1.18380252
65MP0009785_altered_susceptibility_to1.18172793
66MP0000685_abnormal_immune_system1.15804053
67MP0002405_respiratory_system_inflammati1.14967955
68MP0005025_abnormal_response_to1.14389091
69MP0009333_abnormal_splenocyte_physiolog1.14200693
70MP0005164_abnormal_response_to1.13169734
71MP0002136_abnormal_kidney_physiology1.11716682
72MP0005408_hypopigmentation1.11712632
73MP0001756_abnormal_urination1.09954714
74MP0004947_skin_inflammation1.09850335
75MP0003453_abnormal_keratinocyte_physiol1.09266925
76MP0005310_abnormal_salivary_gland1.09174584
77MP0005257_abnormal_intraocular_pressure1.09165823
78MP0006035_abnormal_mitochondrial_morpho1.08617499
79MP0003011_delayed_dark_adaptation1.08001278
80MP0005584_abnormal_enzyme/coenzyme_acti1.07138509
81MP0003279_aneurysm1.06634980
82MP0003329_amyloid_beta_deposits1.06360741
83MP0001533_abnormal_skeleton_physiology1.04893013
84MP0010386_abnormal_urinary_bladder1.04496501
85MP0001819_abnormal_immune_cell1.03622445
86MP0003718_maternal_effect1.03413570
87MP0002420_abnormal_adaptive_immunity1.02231973
88MP0000681_abnormal_thyroid_gland1.01630524
89MP0003172_abnormal_lysosome_physiology1.01393744
90MP0004233_abnormal_muscle_weight1.01349462
91MP0000598_abnormal_liver_morphology1.01214915
92MP0005376_homeostasis/metabolism_phenot0.99901166
93MP0002877_abnormal_melanocyte_morpholog0.99685575
94MP0003656_abnormal_erythrocyte_physiolo0.95806190
95MP0003724_increased_susceptibility_to0.93377813
96MP0000371_diluted_coat_color0.92179177
97MP0000689_abnormal_spleen_morphology0.91430857
98MP0003634_abnormal_glial_cell0.91144976
99MP0002736_abnormal_nociception_after0.90518742
100MP0002295_abnormal_pulmonary_circulatio0.90106205
101MP0000538_abnormal_urinary_bladder0.89968320
102MP0009763_increased_sensitivity_to0.88062964
103MP0003690_abnormal_glial_cell0.87679831
104MP0003123_paternal_imprinting0.86559832
105MP0000015_abnormal_ear_pigmentation0.86302455
106MP0002998_abnormal_bone_remodeling0.85979314
107MP0003300_gastrointestinal_ulcer0.84350063
108MP0002332_abnormal_exercise_endurance0.84245362
109MP0005647_abnormal_sex_gland0.81034703
110MP0000678_abnormal_parathyroid_gland0.80820232
111MP0008007_abnormal_cellular_replicative0.79490687
112MP0000716_abnormal_immune_system0.77996054
113MP0009642_abnormal_blood_homeostasis0.76932456
114MP0010030_abnormal_orbit_morphology0.75735000
115MP0000249_abnormal_blood_vessel0.75471725
116MP0005166_decreased_susceptibility_to0.75392375
117MP0002876_abnormal_thyroid_physiology0.73723439
118MP0010155_abnormal_intestine_physiology0.72986451
119MP0003879_abnormal_hair_cell0.72097440
120MP0000750_abnormal_muscle_regeneration0.71487640
121MP0002132_abnormal_respiratory_system0.67197214
122MP0001849_ear_inflammation0.67064824
123MP0002429_abnormal_blood_cell0.65650707
124MP0002722_abnormal_immune_system0.65633495
125MP0000920_abnormal_myelination0.65074630
126MP0005636_abnormal_mineral_homeostasis0.64860236
127MP0005248_abnormal_Harderian_gland0.64457868
128MP0000343_altered_response_to0.63410567
129MP0006036_abnormal_mitochondrial_physio0.60689486
130MP0003786_premature_aging0.60380639
131MP0001243_abnormal_dermal_layer0.60027952
132MP0001915_intracranial_hemorrhage0.59692157
133MP0005023_abnormal_wound_healing0.59634326
134MP0002229_neurodegeneration0.57402249
135MP0001529_abnormal_vocalization0.56439985
136MP0005084_abnormal_gallbladder_morpholo0.56367803
137MP0002837_dystrophic_cardiac_calcinosis0.56203661
138MP0003795_abnormal_bone_structure0.55418521
139MP0002135_abnormal_kidney_morphology0.55240720
140MP0005075_abnormal_melanosome_morpholog0.55005237
141MP0005390_skeleton_phenotype0.51582753

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.51933095
2Systemic lupus erythematosus (HP:0002725)4.32338621
3Loss of speech (HP:0002371)4.30074909
4Xanthomatosis (HP:0000991)4.15914187
5Abnormality of polysaccharide metabolism (HP:0011012)3.93853886
6Abnormality of glycosaminoglycan metabolism (HP:0004371)3.93853886
7Abnormality of mucopolysaccharide metabolism (HP:0011020)3.93853886
8Prolonged partial thromboplastin time (HP:0003645)3.90417401
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.71947424
10Joint hemorrhage (HP:0005261)3.69374376
11Intrahepatic cholestasis (HP:0001406)3.59789524
12Recurrent bacterial skin infections (HP:0005406)3.57285864
13Recurrent abscess formation (HP:0002722)3.45048128
14Axonal loss (HP:0003447)3.42439320
15Complement deficiency (HP:0004431)3.39280998
16Urinary glycosaminoglycan excretion (HP:0003541)3.38720483
17Mucopolysacchariduria (HP:0008155)3.38720483
18Deep venous thrombosis (HP:0002625)3.34841234
19Vacuolated lymphocytes (HP:0001922)3.29828764
20Recurrent gram-negative bacterial infections (HP:0005420)3.28157554
21Abnormality of methionine metabolism (HP:0010901)3.23836837
22Abnormality of glycolipid metabolism (HP:0010969)3.16487970
23Abnormality of liposaccharide metabolism (HP:0010968)3.16487970
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.16487970
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.06172076
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.03345264
27Nuclear cataract (HP:0100018)3.00395199
28Glomerulonephritis (HP:0000099)2.95788773
29Hyperlipoproteinemia (HP:0010980)2.95749848
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93201562
31Mitral stenosis (HP:0001718)2.90141939
32J-shaped sella turcica (HP:0002680)2.81551126
33Abnormality of complement system (HP:0005339)2.80783184
34Prolonged neonatal jaundice (HP:0006579)2.78582399
35Diminished motivation (HP:0000745)2.78371423
36Mutism (HP:0002300)2.77833791
37Hypobetalipoproteinemia (HP:0003563)2.77803567
38Myocardial infarction (HP:0001658)2.74461510
39Petechiae (HP:0000967)2.73380944
40Abnormality of pyrimidine metabolism (HP:0004353)2.73134634
41Abnormality of fatty-acid metabolism (HP:0004359)2.70083339
42Disinhibition (HP:0000734)2.68828842
43Generalized aminoaciduria (HP:0002909)2.67641536
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.67057292
45Increased cerebral lipofuscin (HP:0011813)2.64348665
46Hyperglycinuria (HP:0003108)2.63482833
47Apathy (HP:0000741)2.62942955
48Hypoalphalipoproteinemia (HP:0003233)2.62377123
49Upper motor neuron abnormality (HP:0002127)2.60296840
50Cardiomegaly (HP:0001640)2.57817626
51Conjugated hyperbilirubinemia (HP:0002908)2.55016261
52Abnormal gallbladder physiology (HP:0012438)2.51221320
53Cholecystitis (HP:0001082)2.51221320
54Hand muscle atrophy (HP:0009130)2.49725934
55Hypolipoproteinemia (HP:0010981)2.49308903
56Fat malabsorption (HP:0002630)2.48794829
57Personality changes (HP:0000751)2.48727149
58Upper limb amyotrophy (HP:0009129)2.48165969
59Distal upper limb amyotrophy (HP:0007149)2.48165969
60Achilles tendon contracture (HP:0001771)2.45043468
61Abnormality of the intrinsic pathway (HP:0010989)2.44914872
62Retinal atrophy (HP:0001105)2.43764134
63Abnormality of the common coagulation pathway (HP:0010990)2.43436003
64Eczematoid dermatitis (HP:0000976)2.41549723
65Increased serum ferritin (HP:0003281)2.41085973
66Neuronal loss in central nervous system (HP:0002529)2.39472840
67Hypoglycemic coma (HP:0001325)2.38635826
68Hepatosplenomegaly (HP:0001433)2.37954563
69Nausea (HP:0002018)2.37562699
70Hyperglycinemia (HP:0002154)2.37083838
71Renal cortical cysts (HP:0000803)2.36596608
72Hyperammonemia (HP:0001987)2.35733038
73Opisthotonus (HP:0002179)2.31926424
74Abnormality of nucleobase metabolism (HP:0010932)2.31411820
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31169159
76Gingival bleeding (HP:0000225)2.28674838
77Proximal tubulopathy (HP:0000114)2.27426775
78Cerebral hypomyelination (HP:0006808)2.26453502
79Spastic paraparesis (HP:0002313)2.25665256
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25624754
81Steatorrhea (HP:0002570)2.22086524
82Abnormality of the Achilles tendon (HP:0005109)2.21337141
83Recurrent skin infections (HP:0001581)2.21260986
84Poor head control (HP:0002421)2.18742760
85Paraparesis (HP:0002385)2.16573264
86Abnormality of glycine metabolism (HP:0010895)2.14692325
87Abnormality of serine family amino acid metabolism (HP:0010894)2.14692325
88Glycosuria (HP:0003076)2.13816754
89Abnormality of urine glucose concentration (HP:0011016)2.13816754
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13147004
91Lethargy (HP:0001254)2.13144620
92Stridor (HP:0010307)2.11054907
93Abnormality of macrophages (HP:0004311)2.10727789
94Abnormality of purine metabolism (HP:0004352)2.10550413
95Pathologic fracture (HP:0002756)2.08758840
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08507954
97Polyphagia (HP:0002591)2.07995997
98Vertebral compression fractures (HP:0002953)2.07536066
99Abnormality of serum amino acid levels (HP:0003112)2.05798535
100Autoimmune thrombocytopenia (HP:0001973)2.04775230
101Hyperbilirubinemia (HP:0002904)2.03049299
102Reticulocytosis (HP:0001923)2.02971274
103Thoracic kyphosis (HP:0002942)2.02135857
104Vascular calcification (HP:0004934)2.01995490
105Hypercholesterolemia (HP:0003124)2.01828881
106Microretrognathia (HP:0000308)2.00419991
107Abnormal enzyme/coenzyme activity (HP:0012379)2.00335114
108Sensorimotor neuropathy (HP:0007141)1.98952914
109Neurofibrillary tangles (HP:0002185)1.98074759
110Hyperthyroidism (HP:0000836)1.97778129
111Elevated alkaline phosphatase (HP:0003155)1.97451698
112Pustule (HP:0200039)1.96977217
113Cheilitis (HP:0100825)1.95707454
114Agitation (HP:0000713)1.95610760
115Abnormal mitochondria in muscle tissue (HP:0008316)1.95252449
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95215829
117Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95215829
118Adrenal hypoplasia (HP:0000835)1.93083408
119Irritability (HP:0000737)1.92845048
120Purpura (HP:0000979)1.91082565
121Abnormality of proline metabolism (HP:0010907)1.90915155
122Hydroxyprolinuria (HP:0003080)1.90915155
123Basal ganglia calcification (HP:0002135)1.90896725
124Agnosia (HP:0010524)1.90605692
125Dementia (HP:0000726)1.90373946
126Metaphyseal irregularity (HP:0003025)1.89587050
127Epiphyseal stippling (HP:0010655)1.89077849
128Dysostosis multiplex (HP:0000943)1.88636841
129Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88586766
130Abnormality of alkaline phosphatase activity (HP:0004379)1.88487679
131Abnormality of iron homeostasis (HP:0011031)1.88444246
132Hypokinesia (HP:0002375)1.88335874
133Cerebral edema (HP:0002181)1.87943388
134Supranuclear gaze palsy (HP:0000605)1.83950646
135Ragged-red muscle fibers (HP:0003200)1.83208247
136Abnormality of transition element cation homeostasis (HP:0011030)1.82394538
137Anorexia (HP:0002039)1.81912905
138Progressive neurologic deterioration (HP:0002344)1.79002660
139Tetraparesis (HP:0002273)1.78922701
140Rough bone trabeculation (HP:0100670)1.78176872
141Dicarboxylic aciduria (HP:0003215)1.77856126
142Cortical visual impairment (HP:0100704)1.75803336
143Abnormality of the gallbladder (HP:0005264)1.74189932
144Joint stiffness (HP:0001387)1.71395594
145Mesangial abnormality (HP:0001966)1.71001512
146Amyloidosis (HP:0011034)1.70084009
147Myoclonus (HP:0001336)1.65619761
148Parakeratosis (HP:0001036)1.63428660
149Abnormal protein glycosylation (HP:0012346)1.62095957
150Abnormal glycosylation (HP:0012345)1.62095957
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62095957
152Abnormal protein N-linked glycosylation (HP:0012347)1.62095957
153Abnormal trabecular bone morphology (HP:0100671)1.61890905
154Acute necrotizing encephalopathy (HP:0006965)1.61750168
155Protuberant abdomen (HP:0001538)1.61297267
156Abnormality of the vasculature of the conjunctiva (HP:0008054)1.61165189
157Acute encephalopathy (HP:0006846)1.60923356
158Abnormality of the distal phalanges of the toes (HP:0010182)1.60131044
159Type I transferrin isoform profile (HP:0003642)1.58877015
160Increased muscle lipid content (HP:0009058)1.58368877
161Natal tooth (HP:0000695)1.57431853
162Broad distal phalanx of finger (HP:0009836)1.57234166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.02156082
2MAP3K143.12008907
3PRPF4B2.77557453
4AKT32.63025291
5BUB12.49221230
6EPHA22.41065601
7SIK32.34596648
8IRAK42.34475636
9ERN12.32076935
10BLK2.22287631
11BCKDK2.20869325
12MAP2K32.18265062
13CSNK1G32.03504518
14TYK22.01524568
15TGFBR22.00253985
16TBK11.98814894
17MAP4K11.88092220
18GRK71.87579611
19FGFR41.84834902
20TAOK11.83834415
21ICK1.81031267
22KIT1.75953067
23EIF2AK11.69840030
24SMG11.67821960
25CSNK1G21.65906576
26CLK11.64524220
27PRKD21.63889698
28MAP3K31.57191076
29SGK21.53795057
30IKBKE1.53730588
31CSNK1A1L1.51339602
32TIE11.49610335
33CASK1.49113835
34PRKD31.45588050
35EIF2AK21.44967988
36YES11.41637115
37IKBKB1.31900675
38CSNK1G11.30775017
39PBK1.30539348
40PINK11.28831896
41CAMK1D1.28246669
42STK38L1.28160696
43STK161.22907653
44DDR21.22444896
45ADRBK21.19390969
46SGK2231.18709024
47SGK4941.18709024
48ZAK1.17569050
49KDR1.17514798
50STK101.17068107
51CAMKK21.16977364
52SGK31.12098547
53DAPK31.11475247
54EPHB11.11053465
55TRIB31.11021806
56NEK91.10047566
57NME21.08292221
58ABL21.06321441
59GRK11.03858952
60MAP3K111.03642756
61DYRK31.03426812
62PIM11.03128665
63ZAP700.99172383
64TSSK60.99069671
65MAP2K70.98343980
66PLK40.96189647
67SIK10.95829005
68IRAK20.95670636
69MARK30.95242646
70TESK20.95203281
71BCR0.95132195
72EPHB20.95112201
73TRPM70.94743930
74EIF2AK30.91873226
75LIMK10.91573269
76BMPR20.91432325
77PIM20.88182101
78SYK0.86755013
79DAPK10.85940434
80PIK3CG0.85741700
81LYN0.85667530
82BRAF0.85199543
83CSK0.84409495
84JAK10.80858993
85DYRK1B0.78180605
86MATK0.76964334
87CHUK0.76191754
88SCYL20.75605214
89PRKCI0.73183424
90IRAK10.68232774
91RPS6KA20.67388557
92MAP4K20.66897674
93MAP3K80.65762969
94PDK20.65216622
95MAP3K60.65163695
96VRK20.64582859
97TAOK20.64532139
98TESK10.64335952
99ITK0.64032483
100PAK40.60268528
101JAK30.59371862
102CSF1R0.58740214
103AURKA0.58730816
104MARK20.57577303
105PLK20.56343192
106BTK0.55881006
107EPHA30.54798591
108DYRK20.54477897
109MAP2K20.54095589
110TNK20.54087020
111MAP3K10.52619086
112CDC42BPA0.51628966
113PRKCD0.51577897
114STK40.50841374
115TLK10.50190055
116SRPK10.50132389
117MAP3K50.49807576
118PTK20.49768199
119LMTK20.49303588
120PAK10.48975318
121GSK3A0.48847930
122RPS6KL10.48472565
123RPS6KC10.48472565
124MAP2K60.47390852
125CAMK2G0.47038184
126RPS6KA40.46929146
127HCK0.45879232
128PAK60.44242821
129MAPKAPK30.43902419
130MAPK70.43451232
131GRK60.43176437
132DAPK20.41591161
133LCK0.40713525
134MST1R0.40390387
135AKT20.39390311
136CDK140.39151453
137ERBB40.39000079
138PRKG20.38878080
139FER0.38628325
140RPS6KA50.38484038
141RPS6KA60.38354424
142MAPK110.38139124
143FGR0.37172051
144MOS0.36872197
145PTK60.34401836
146TXK0.34041234
147MAPK120.33006397
148BMX0.32902780
149EGFR0.32519356
150CDK70.31140693
151PRKCG0.31010015
152MET0.30792695
153PDPK10.30550386
154ARAF0.29718887
155MAPKAPK20.29418716
156FLT30.29122209
157CSNK1A10.28916285
158CDK11A0.28804761

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.71069114
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.00036534
3Proteasome_Homo sapiens_hsa030502.80469362
4Complement and coagulation cascades_Homo sapiens_hsa046102.72610455
5Staphylococcus aureus infection_Homo sapiens_hsa051502.62774425
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34691230
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23722255
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22957761
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21883617
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17753055
11Galactose metabolism_Homo sapiens_hsa000522.16252042
12Peroxisome_Homo sapiens_hsa041462.08463516
13Steroid biosynthesis_Homo sapiens_hsa001002.05800395
14Folate biosynthesis_Homo sapiens_hsa007902.04776238
15Lysosome_Homo sapiens_hsa041421.92871905
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90663502
17Arginine biosynthesis_Homo sapiens_hsa002201.86835242
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.84826769
19Tryptophan metabolism_Homo sapiens_hsa003801.81073093
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79439516
21Fatty acid elongation_Homo sapiens_hsa000621.78217676
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.77267593
23Histidine metabolism_Homo sapiens_hsa003401.74459566
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63865147
25Vitamin B6 metabolism_Homo sapiens_hsa007501.58567499
26Synaptic vesicle cycle_Homo sapiens_hsa047211.49147790
27Selenocompound metabolism_Homo sapiens_hsa004501.47123311
28RNA polymerase_Homo sapiens_hsa030201.45058450
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44940103
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44217568
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42532113
32beta-Alanine metabolism_Homo sapiens_hsa004101.42269771
33Chemical carcinogenesis_Homo sapiens_hsa052041.41268911
34Butanoate metabolism_Homo sapiens_hsa006501.39664884
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.35526769
36Fatty acid degradation_Homo sapiens_hsa000711.34853360
37Phenylalanine metabolism_Homo sapiens_hsa003601.33993718
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32506082
39Other glycan degradation_Homo sapiens_hsa005111.31686778
40Salmonella infection_Homo sapiens_hsa051321.28921921
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28862193
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28643634
43Bladder cancer_Homo sapiens_hsa052191.28239275
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27144485
45Caffeine metabolism_Homo sapiens_hsa002321.25603199
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.24363178
47One carbon pool by folate_Homo sapiens_hsa006701.23723829
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20758835
49Regulation of autophagy_Homo sapiens_hsa041401.20002624
50Vitamin digestion and absorption_Homo sapiens_hsa049771.15078964
51N-Glycan biosynthesis_Homo sapiens_hsa005101.13959262
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13790730
53Fatty acid metabolism_Homo sapiens_hsa012121.10783119
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.09611206
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08722010
56Arginine and proline metabolism_Homo sapiens_hsa003301.07363794
57Sulfur metabolism_Homo sapiens_hsa009201.07138303
58Glutathione metabolism_Homo sapiens_hsa004801.05802816
59Retinol metabolism_Homo sapiens_hsa008301.05292931
60Sulfur relay system_Homo sapiens_hsa041221.04410053
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98360136
62PPAR signaling pathway_Homo sapiens_hsa033200.97052711
63Biosynthesis of amino acids_Homo sapiens_hsa012300.94006422
64Carbon metabolism_Homo sapiens_hsa012000.93847096
65Osteoclast differentiation_Homo sapiens_hsa043800.92806388
66Collecting duct acid secretion_Homo sapiens_hsa049660.92460868
67Nitrogen metabolism_Homo sapiens_hsa009100.90996806
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89716574
69Legionellosis_Homo sapiens_hsa051340.88337999
70Phagosome_Homo sapiens_hsa041450.88169522
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87534488
72Pyrimidine metabolism_Homo sapiens_hsa002400.86514367
73Pentose phosphate pathway_Homo sapiens_hsa000300.86303499
74Base excision repair_Homo sapiens_hsa034100.85157834
75Propanoate metabolism_Homo sapiens_hsa006400.84654603
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84592181
77Shigellosis_Homo sapiens_hsa051310.84258577
78Tyrosine metabolism_Homo sapiens_hsa003500.83457411
79Pyruvate metabolism_Homo sapiens_hsa006200.79607422
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.79172770
81Arachidonic acid metabolism_Homo sapiens_hsa005900.78438553
82Vibrio cholerae infection_Homo sapiens_hsa051100.77450158
83Fat digestion and absorption_Homo sapiens_hsa049750.75352874
84ABC transporters_Homo sapiens_hsa020100.74557138
85Metabolic pathways_Homo sapiens_hsa011000.73909027
86Rheumatoid arthritis_Homo sapiens_hsa053230.73864336
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72561802
88Prion diseases_Homo sapiens_hsa050200.72482028
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70728457
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67404411
91Starch and sucrose metabolism_Homo sapiens_hsa005000.67040826
92Tuberculosis_Homo sapiens_hsa051520.61738323
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.61355219
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61240774
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60988417
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.60802017
97Parkinsons disease_Homo sapiens_hsa050120.59141447
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58763409
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58590322
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58292457
101Ether lipid metabolism_Homo sapiens_hsa005650.55725457
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.55215664
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54697435
104Pertussis_Homo sapiens_hsa051330.53774537
105TNF signaling pathway_Homo sapiens_hsa046680.52708919
106Oxidative phosphorylation_Homo sapiens_hsa001900.52369129
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51620960
108Malaria_Homo sapiens_hsa051440.51333117
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50775084
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.50364532
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49943757
112Fructose and mannose metabolism_Homo sapiens_hsa000510.49074314
113Epstein-Barr virus infection_Homo sapiens_hsa051690.48945317
114Sphingolipid metabolism_Homo sapiens_hsa006000.48693679
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47768282
116Notch signaling pathway_Homo sapiens_hsa043300.45174819
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44965055
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43796882
119Linoleic acid metabolism_Homo sapiens_hsa005910.42743436
120Mineral absorption_Homo sapiens_hsa049780.41656327
121Leishmaniasis_Homo sapiens_hsa051400.40754350
122Renin-angiotensin system_Homo sapiens_hsa046140.39353592
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39192782
124Apoptosis_Homo sapiens_hsa042100.38132643
125Primary immunodeficiency_Homo sapiens_hsa053400.37592248
126Endocytosis_Homo sapiens_hsa041440.37404581
127Hematopoietic cell lineage_Homo sapiens_hsa046400.37299452
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37203374
129Non-homologous end-joining_Homo sapiens_hsa034500.34519312
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.34452643
131Huntingtons disease_Homo sapiens_hsa050160.32088560
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30435126
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29488367
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.27587430
135Hepatitis C_Homo sapiens_hsa051600.22028534
136VEGF signaling pathway_Homo sapiens_hsa043700.21278651
137Alzheimers disease_Homo sapiens_hsa050100.20022578

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