PQLC2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte chemotaxis (GO:0002689)5.20478661
2membrane raft organization (GO:0031579)4.89234514
3peptidyl-proline hydroxylation (GO:0019511)4.68528332
4response to nitrosative stress (GO:0051409)4.42347901
5protein hydroxylation (GO:0018126)4.16621229
6xenobiotic catabolic process (GO:0042178)4.08284445
7proteasome assembly (GO:0043248)4.06624061
8protein heterotrimerization (GO:0070208)3.95430514
9regulation of macrophage chemotaxis (GO:0010758)3.90305720
10regulation of integrin-mediated signaling pathway (GO:2001044)3.88814345
11mesenchymal-epithelial cell signaling (GO:0060638)3.80953497
12response to redox state (GO:0051775)3.78299602
13triglyceride catabolic process (GO:0019433)3.68182932
14kidney mesenchyme development (GO:0072074)3.68130537
15cellular response to vitamin (GO:0071295)3.67122500
16collagen fibril organization (GO:0030199)3.66379886
17low-density lipoprotein particle clearance (GO:0034383)3.60647161
18cell migration involved in heart development (GO:0060973)3.58609872
19regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.53315515
20extracellular fibril organization (GO:0043206)3.50210765
21protein localization to cell surface (GO:0034394)3.45831033
22endodermal cell differentiation (GO:0035987)3.42499610
23metanephric mesenchyme development (GO:0072075)3.40962765
24retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39324762
25blood vessel maturation (GO:0001955)3.38945217
26positive regulation of endothelial cell apoptotic process (GO:2000353)3.23921786
27regulation of extracellular matrix disassembly (GO:0010715)3.23292016
28regulation of metalloenzyme activity (GO:0048552)3.23225138
29protein retention in ER lumen (GO:0006621)3.21196862
30regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16414030
31keratan sulfate catabolic process (GO:0042340)3.16314653
32lipid particle organization (GO:0034389)3.16199038
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08373209
34acylglycerol catabolic process (GO:0046464)3.07236887
35neutral lipid catabolic process (GO:0046461)3.07236887
36positive regulation of cell junction assembly (GO:1901890)3.06048385
37positive regulation of focal adhesion assembly (GO:0051894)3.06048385
38negative regulation of metanephros development (GO:0072217)3.05301000
39CDP-diacylglycerol biosynthetic process (GO:0016024)3.05299087
40regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.03548715
41retinol metabolic process (GO:0042572)3.01324392
42negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.99380105
43positive regulation of osteoblast proliferation (GO:0033690)2.99337401
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97370867
45type B pancreatic cell proliferation (GO:0044342)2.95452424
46negative regulation of endothelial cell proliferation (GO:0001937)2.93502999
47retinal metabolic process (GO:0042574)2.92260438
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.88961431
49negative regulation of protein localization to plasma membrane (GO:1903077)2.87618682
50response to hyperoxia (GO:0055093)2.86265899
51response to increased oxygen levels (GO:0036296)2.86265899
52regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.84039526
53fatty acid elongation (GO:0030497)2.84017158
54negative regulation of nitric-oxide synthase activity (GO:0051001)2.83101971
55positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.82182791
56metanephric tubule development (GO:0072170)2.80623592
57metanephric nephron tubule development (GO:0072234)2.80623592
58hyaluronan catabolic process (GO:0030214)2.79382858
59substrate adhesion-dependent cell spreading (GO:0034446)2.79351092
60positive regulation of adherens junction organization (GO:1903393)2.77448675
61regulation of sequestering of triglyceride (GO:0010889)2.75081342
62fatty acid homeostasis (GO:0055089)2.74159842
63fibril organization (GO:0097435)2.71536807
64negative regulation of BMP signaling pathway (GO:0030514)2.71457164
65metanephric nephron epithelium development (GO:0072243)2.71327156
66smooth muscle tissue development (GO:0048745)2.70912671
67negative regulation of smooth muscle cell migration (GO:0014912)2.70872619
68endocrine hormone secretion (GO:0060986)2.69708104
69CDP-diacylglycerol metabolic process (GO:0046341)2.69428555
70positive regulation of extracellular matrix organization (GO:1903055)2.67272293
71positive regulation of fibroblast migration (GO:0010763)2.65392093
72positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.65271665
73cellular response to vitamin D (GO:0071305)2.65189901
74membrane assembly (GO:0071709)2.63904495
75protein heterotetramerization (GO:0051290)2.60942291
76endothelial cell proliferation (GO:0001935)2.60144438
77substrate-dependent cell migration (GO:0006929)2.59022597
78artery development (GO:0060840)2.57806609
79membrane budding (GO:0006900)2.56894451
80metanephric epithelium development (GO:0072207)2.56121160
81negative regulation of cartilage development (GO:0061037)2.55116047
82nucleotide-sugar biosynthetic process (GO:0009226)2.52108721
83endothelial cell morphogenesis (GO:0001886)2.51649386
84cellular response to zinc ion (GO:0071294)2.51364888
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50443075
86extracellular matrix assembly (GO:0085029)2.47882316
87protein maturation by protein folding (GO:0022417)2.47315136
88primary alcohol metabolic process (GO:0034308)2.47065900
89endocardial cushion development (GO:0003197)2.43556608
904-hydroxyproline metabolic process (GO:0019471)2.43283470
91erythrocyte maturation (GO:0043249)2.43182840
92sequestering of extracellular ligand from receptor (GO:0035581)2.41688421
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.40727835
94activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.40406526
95muscle cell migration (GO:0014812)2.35400916
96chondrocyte proliferation (GO:0035988)2.33768904
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33376320
98negative regulation of chondrocyte differentiation (GO:0032331)2.31102370
99white fat cell differentiation (GO:0050872)2.30488427
100regulation of apoptotic process involved in morphogenesis (GO:1902337)2.30455845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.82751968
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.59193502
3CJUN_26792858_Chip-Seq_BT549_Human3.32481956
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.22446124
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15858731
6GBX2_23144817_ChIP-Seq_PC3_Human3.09902958
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.07085008
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.89824902
9CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.87811689
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.80485633
11BRD4_25478319_ChIP-Seq_HGPS_Human2.75114261
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.63697999
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.56644408
14PPAR_26484153_Chip-Seq_NCI-H1993_Human2.49676365
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.35412740
16TP53_18474530_ChIP-ChIP_U2OS_Human2.23333406
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.18552227
18NRF2_20460467_ChIP-Seq_MEFs_Mouse2.17470326
19NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.17470326
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.14424045
21ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.11507447
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07173697
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95831630
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95831630
25JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95466482
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95263171
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.92172210
28JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88707101
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84432018
30CLOCK_20551151_ChIP-Seq_293T_Human1.83579812
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82440995
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82318250
33TP53_16413492_ChIP-PET_HCT116_Human1.79612656
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.70138783
35MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.68878104
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.61360082
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55783847
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53625194
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47585285
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47434477
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46981444
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43568813
43PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.43216538
44EOMES_21245162_ChIP-Seq_HESCs_Human1.35707004
45SOX2_20726797_ChIP-Seq_SW620_Human1.34463334
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26270187
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24481001
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24385208
49ELK1_19687146_ChIP-ChIP_HELA_Human1.24252869
50SA1_22415368_ChIP-Seq_MEFs_Mouse1.23287085
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18461100
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.17320309
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17238233
54PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16287325
55AR_21909140_ChIP-Seq_LNCAP_Human1.15325762
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14303116
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.13541465
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12835041
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12451014
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09834250
61SMAD4_21799915_ChIP-Seq_A2780_Human1.08154410
62TP63_23658742_ChIP-Seq_EP156T_Human1.08030878
63AR_25329375_ChIP-Seq_VCAP_Human1.07831541
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.06267175
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06098130
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05776160
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.05756465
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05103180
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04330255
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.04163906
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.04163906
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.03723826
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01153647
74EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00751309
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00735634
76GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00223519
77P300_19829295_ChIP-Seq_ESCs_Human0.99514134
78ESR1_21235772_ChIP-Seq_MCF-7_Human0.99449632
79UBF1/2_26484160_Chip-Seq_HMECs_Human0.98768602
80SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98290202
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98018454
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.97680282
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97342288
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94070120
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.90220585
86PHF8_20622853_ChIP-Seq_HELA_Human0.89977833
87JUN_21703547_ChIP-Seq_K562_Human0.88721002
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.88014125
89NFI_21473784_ChIP-Seq_ESCs_Mouse0.87899509
90CDX2_22108803_ChIP-Seq_LS180_Human0.87770839
91FUS_26573619_Chip-Seq_HEK293_Human0.87695366
92CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87424085
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.86985531
94PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.86584717
95TBL1_22424771_ChIP-Seq_293T_Human0.85649240
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84666737
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84095145
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81369477
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.81165834
100GATA4_25053715_ChIP-Seq_YYC3_Human0.80124569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.32745324
2MP0004272_abnormal_basement_membrane4.55998531
3MP0003950_abnormal_plasma_membrane4.29886369
4MP0005503_abnormal_tendon_morphology3.67586590
5MP0005275_abnormal_skin_tensile3.51951181
6MP0005670_abnormal_white_adipose3.26524844
7MP0006054_spinal_hemorrhage2.99913793
8MP0003705_abnormal_hypodermis_morpholog2.86230542
9MP0001958_emphysema2.61754044
10MP0010386_abnormal_urinary_bladder2.49631868
11MP0003279_aneurysm2.16250449
12MP0010368_abnormal_lymphatic_system2.10861671
13MP0003186_abnormal_redox_activity2.07268607
14MP0005257_abnormal_intraocular_pressure1.95258464
15MP0000003_abnormal_adipose_tissue1.91954319
16MP0003941_abnormal_skin_development1.91193806
17MP0001542_abnormal_bone_strength1.88807364
18MP0005379_endocrine/exocrine_gland_phen1.86712683
19MP0005375_adipose_tissue_phenotype1.81574498
20MP0005084_abnormal_gallbladder_morpholo1.80254590
21MP0000749_muscle_degeneration1.80076509
22MP0002060_abnormal_skin_morphology1.75692195
23MP0005023_abnormal_wound_healing1.67700675
24MP0003195_calcinosis1.66399940
25MP0005666_abnormal_adipose_tissue1.66136399
26MP0003011_delayed_dark_adaptation1.59941399
27MP0002295_abnormal_pulmonary_circulatio1.58119590
28MP0005595_abnormal_vascular_smooth1.57327601
29MP0002971_abnormal_brown_adipose1.56243311
30MP0005164_abnormal_response_to1.55290433
31MP0009780_abnormal_chondrocyte_physiolo1.53696881
32MP0003566_abnormal_cell_adhesion1.52295065
33MP0005508_abnormal_skeleton_morphology1.44792311
34MP0009250_abnormal_appendicular_skeleto1.43139373
35MP0001879_abnormal_lymphatic_vessel1.40006123
36MP0010678_abnormal_skin_adnexa1.38895000
37MP0002108_abnormal_muscle_morphology1.32887735
38MP0000343_altered_response_to1.29382673
39MP0004883_abnormal_blood_vessel1.25282365
40MP0009697_abnormal_copulation1.24334895
41MP0001299_abnormal_eye_distance/1.23714065
42MP0005623_abnormal_meninges_morphology1.21753154
43MP0000762_abnormal_tongue_morphology1.21482384
44MP0002970_abnormal_white_adipose1.21032468
45MP0002896_abnormal_bone_mineralization1.17024908
46MP0003828_pulmonary_edema1.14358589
47MP0003091_abnormal_cell_migration1.13779824
48MP0000647_abnormal_sebaceous_gland1.13119982
49MP0000767_abnormal_smooth_muscle1.11774153
50MP0009384_cardiac_valve_regurgitation1.10111152
51MP0004185_abnormal_adipocyte_glucose1.09032981
52MP0001243_abnormal_dermal_layer1.08642902
53MP0002796_impaired_skin_barrier1.07116281
54MP0010030_abnormal_orbit_morphology1.06638303
55MP0009115_abnormal_fat_cell1.03511701
56MP0000751_myopathy1.03246894
57MP0003252_abnormal_bile_duct1.03055834
58MP0000750_abnormal_muscle_regeneration1.02987363
59MP0005197_abnormal_uvea_morphology1.02555228
60MP0005165_increased_susceptibility_to0.99986414
61MP0009053_abnormal_anal_canal0.97714422
62MP0003959_abnormal_lean_body0.97379505
63MP0003191_abnormal_cellular_cholesterol0.97014492
64MP0001915_intracranial_hemorrhage0.93036336
65MP0001727_abnormal_embryo_implantation0.90433021
66MP0005193_abnormal_anterior_eye0.89685857
67MP0010771_integument_phenotype0.88655011
68MP0006138_congestive_heart_failure0.88423087
69MP0000759_abnormal_skeletal_muscle0.87095683
70MP0000428_abnormal_craniofacial_morphol0.84387430
71MP0001661_extended_life_span0.83926385
72MP0001881_abnormal_mammary_gland0.83207231
73MP0000163_abnormal_cartilage_morphology0.81102879
74MP0000013_abnormal_adipose_tissue0.81101580
75MP0005385_cardiovascular_system_phenoty0.80610147
76MP0001544_abnormal_cardiovascular_syste0.80610147
77MP0001851_eye_inflammation0.78258193
78MP0003868_abnormal_feces_composition0.77269001
79MP0005452_abnormal_adipose_tissue0.76741502
80MP0005332_abnormal_amino_acid0.76362413
81MP0004130_abnormal_muscle_cell0.75279859
82MP0002282_abnormal_trachea_morphology0.75256708
83MP0004233_abnormal_muscle_weight0.74273343
84MP0002972_abnormal_cardiac_muscle0.72264546
85MP0010329_abnormal_lipoprotein_level0.70859744
86MP0000534_abnormal_ureter_morphology0.68874264
87MP0002128_abnormal_blood_circulation0.68151896
88MP0002234_abnormal_pharynx_morphology0.67965638
89MP0000747_muscle_weakness0.67182458
90MP0004084_abnormal_cardiac_muscle0.66269832
91MP0010352_gastrointestinal_tract_polyps0.65417877
92MP0002876_abnormal_thyroid_physiology0.63182005
93MP0000230_abnormal_systemic_arterial0.62931407
94MP0001270_distended_abdomen0.62253124
95MP0005620_abnormal_muscle_contractility0.61530076
96MP0000249_abnormal_blood_vessel0.59771876
97MP0002168_other_aberrant_phenotype0.59555323
98MP0002269_muscular_atrophy0.59520612
99MP0002115_abnormal_skeleton_extremities0.59492773
100MP0005334_abnormal_fat_pad0.59442093

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.46848989
2Osteolytic defects of the hand bones (HP:0009699)5.72594043
3Osteolytic defects of the phalanges of the hand (HP:0009771)5.72594043
4Premature rupture of membranes (HP:0001788)5.56116174
5Aortic aneurysm (HP:0004942)5.26722546
6Vascular tortuosity (HP:0004948)5.01722803
7Wormian bones (HP:0002645)4.64764609
8Aortic dissection (HP:0002647)4.63762698
9Autoamputation (HP:0001218)4.37989058
10Vertebral compression fractures (HP:0002953)3.99645183
11Soft skin (HP:0000977)3.94556284
12Arterial tortuosity (HP:0005116)3.90524844
13Follicular hyperkeratosis (HP:0007502)3.87093303
14Spondylolisthesis (HP:0003302)3.56655251
15Ankle contracture (HP:0006466)3.19688327
16Hyporeflexia of lower limbs (HP:0002600)3.11006317
17Spinal rigidity (HP:0003306)2.98755600
183-Methylglutaconic aciduria (HP:0003535)2.94558269
19Increased variability in muscle fiber diameter (HP:0003557)2.93769487
20Abnormality of dentin (HP:0010299)2.90888834
21Glucose intolerance (HP:0000833)2.84418104
22Renal Fanconi syndrome (HP:0001994)2.80666610
23Reduced subcutaneous adipose tissue (HP:0003758)2.78525370
24Dilatation of the ascending aorta (HP:0005111)2.67954200
25Atrophic scars (HP:0001075)2.67320186
26Type 1 muscle fiber predominance (HP:0003803)2.63432081
27Muscle fiber splitting (HP:0003555)2.63192165
28Abnormality of skeletal muscle fiber size (HP:0012084)2.59151005
29Metaphyseal dysplasia (HP:0100255)2.57305254
30Cervical subluxation (HP:0003308)2.49283457
31Hydroxyprolinuria (HP:0003080)2.48853507
32Abnormality of proline metabolism (HP:0010907)2.48853507
33Slender build (HP:0001533)2.46886289
34Acanthosis nigricans (HP:0000956)2.45679113
35Blue sclerae (HP:0000592)2.40812231
36Ectopia lentis (HP:0001083)2.38143595
37Cardiovascular calcification (HP:0011915)2.37746379
38Microglossia (HP:0000171)2.37053173
39Acute necrotizing encephalopathy (HP:0006965)2.30054267
40Fragile skin (HP:0001030)2.27054934
41Mitral regurgitation (HP:0001653)2.22067964
42Bladder diverticulum (HP:0000015)2.21564400
43Absent frontal sinuses (HP:0002688)2.18255375
44Lipoatrophy (HP:0100578)2.17828323
45Neonatal short-limb short stature (HP:0008921)2.16459555
46Neck muscle weakness (HP:0000467)2.16257275
47Broad metatarsal (HP:0001783)2.13662907
48Delayed cranial suture closure (HP:0000270)2.12757889
49Acute encephalopathy (HP:0006846)2.09670176
50Tetraparesis (HP:0002273)2.09294483
51Delayed closure of the anterior fontanelle (HP:0001476)2.08097494
52Nuclear cataract (HP:0100018)2.07017623
53Abnormal mitochondria in muscle tissue (HP:0008316)2.06614776
54Abnormality of placental membranes (HP:0011409)2.05668865
55Amniotic constriction ring (HP:0009775)2.05668865
56Biconcave vertebral bodies (HP:0004586)2.04833386
57Mitochondrial inheritance (HP:0001427)2.03375163
58Exertional dyspnea (HP:0002875)2.02825463
59Progressive macrocephaly (HP:0004481)2.01740888
60Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99184832
61Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97405197
62Mildly elevated creatine phosphokinase (HP:0008180)1.96286010
63Mitral stenosis (HP:0001718)1.94721094
64Joint laxity (HP:0001388)1.94466960
65Mitral valve prolapse (HP:0001634)1.93522876
66Knee flexion contracture (HP:0006380)1.92776248
67Increased hepatocellular lipid droplets (HP:0006565)1.92216658
68Patent foramen ovale (HP:0001655)1.89884211
69Delayed gross motor development (HP:0002194)1.84839886
70Aplasia of the musculature (HP:0100854)1.84770006
71Hypertriglyceridemia (HP:0002155)1.84270968
72Aortic regurgitation (HP:0001659)1.83994864
73Abnormality of the fetal cardiovascular system (HP:0010948)1.82198112
74Abnormal umbilical cord blood vessels (HP:0011403)1.82198112
75Single umbilical artery (HP:0001195)1.82198112
76Abnormality of the anterior chamber (HP:0000593)1.81620747
77Abnormality of the acetabulum (HP:0003170)1.79900049
78Elbow flexion contracture (HP:0002987)1.79478458
79Hepatocellular necrosis (HP:0001404)1.78666455
80Abnormal glucose tolerance (HP:0001952)1.77098909
81Bone cyst (HP:0012062)1.76769816
82Hyperalaninemia (HP:0003348)1.75273275
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75273275
84Abnormality of alanine metabolism (HP:0010916)1.75273275
85Generalized amyotrophy (HP:0003700)1.73670484
86Hyperextensible skin (HP:0000974)1.73638398
87Cerebral edema (HP:0002181)1.70523546
88Oligomenorrhea (HP:0000876)1.70021980
89Genu recurvatum (HP:0002816)1.69664476
90Redundant skin (HP:0001582)1.68839894
91Increased muscle lipid content (HP:0009058)1.68570493
92Abnormalities of placenta or umbilical cord (HP:0001194)1.68265557
93Vascular calcification (HP:0004934)1.67864201
94Overgrowth (HP:0001548)1.67805273
95Respiratory insufficiency due to muscle weakness (HP:0002747)1.65971132
96Nemaline bodies (HP:0003798)1.64276901
97Abnormality of renal resorption (HP:0011038)1.63965941
98Abnormal delivery (HP:0001787)1.63494733
99Abnormality of the umbilical cord (HP:0010881)1.63364970
100Shallow orbits (HP:0000586)1.63229605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK26.27286827
2MAP3K125.56992056
3MYLK5.06269647
4WEE13.76666233
5PBK2.89993748
6BRSK12.66745266
7NEK92.33276853
8PAK42.28500525
9EPHB22.15444424
10DDR22.09503733
11MST41.92088099
12TGFBR21.87865898
13TESK11.84157975
14EIF2AK11.80339130
15BCR1.68155847
16LATS21.67853364
17LIMK11.54545217
18ABL21.42732434
19ILK1.39924580
20VRK21.39733010
21PTK21.32446884
22ARAF1.31666271
23MST1R1.31118597
24TRIM281.27178269
25EIF2AK31.23130098
26PAK21.20176689
27PDGFRA1.19683781
28MAP3K131.18423517
29NME21.18363185
30ERBB41.17504152
31CASK1.15520552
32STK161.14060334
33DAPK31.12514007
34BMPR1B1.12149774
35NEK11.09930183
36MOS1.08643033
37CDK81.04404636
38PKN10.98501121
39TIE10.98052117
40GRK50.96996477
41FLT30.96906800
42STK38L0.92032694
43MET0.89909052
44LATS10.85815715
45TAF10.85529979
46ADRBK10.82572494
47NUAK10.79376702
48ROCK10.79330445
49BUB10.77459180
50STK380.76570980
51TRPM70.71209386
52MUSK0.69813389
53EPHA20.69679288
54GSK3A0.67499812
55PRKCE0.67262872
56DAPK10.66496918
57EIF2AK20.65732608
58SMG10.64740021
59SIK30.63380663
60PRKD20.62336593
61MAP2K10.61622166
62ROCK20.58748632
63PINK10.58517517
64ERBB30.57472845
65PIM20.56930625
66CAMK2G0.56186007
67SIK10.54167278
68MKNK20.50940286
69FER0.49576180
70PIK3CG0.48771423
71PLK20.47418579
72NTRK10.46864827
73PDGFRB0.46072308
74AURKA0.45896620
75GRK10.45563002
76CDK90.43910055
77PRKG10.40742501
78PAK10.40411762
79PRKAA20.39875792
80CDK40.37568140
81PNCK0.37178465
82TAOK20.36497982
83MAPK70.35632263
84MAP3K30.34265774
85NME10.33127011
86PLK30.32253276
87GRK70.31747386
88PLK10.30989339
89TNIK0.28966557
90CAMK2D0.28308363
91FGFR10.28268224
92TTK0.28258619
93MAPKAPK20.28229521
94ABL10.27612508
95SCYL20.26784911
96STK30.25879422
97PTK2B0.24244805
98CAMK2B0.24218835
99PRKD10.22501881
100ADRBK20.21350999

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.16926019
2Fatty acid elongation_Homo sapiens_hsa000623.16132457
3ECM-receptor interaction_Homo sapiens_hsa045123.00689088
4Propanoate metabolism_Homo sapiens_hsa006402.56436067
5Sulfur metabolism_Homo sapiens_hsa009202.55048048
6Protein export_Homo sapiens_hsa030602.54084832
7Oxidative phosphorylation_Homo sapiens_hsa001902.26180791
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25851632
9Glutathione metabolism_Homo sapiens_hsa004802.02582941
10PPAR signaling pathway_Homo sapiens_hsa033202.01291811
11Pyruvate metabolism_Homo sapiens_hsa006201.91583128
12Parkinsons disease_Homo sapiens_hsa050121.89663176
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89156401
14Focal adhesion_Homo sapiens_hsa045101.82567445
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66702101
16Sulfur relay system_Homo sapiens_hsa041221.66223525
17Glycerolipid metabolism_Homo sapiens_hsa005611.64048867
18Fatty acid degradation_Homo sapiens_hsa000711.58691040
19Vitamin B6 metabolism_Homo sapiens_hsa007501.54058349
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54001314
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53750533
22Alzheimers disease_Homo sapiens_hsa050101.51924619
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45348261
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42075750
25Huntingtons disease_Homo sapiens_hsa050161.41626317
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41332699
27Folate biosynthesis_Homo sapiens_hsa007901.39312392
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38910001
29Regulation of autophagy_Homo sapiens_hsa041401.37410189
30Tyrosine metabolism_Homo sapiens_hsa003501.36732722
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30333212
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29955229
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29010403
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24074606
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22280712
36Protein digestion and absorption_Homo sapiens_hsa049741.12695099
37Fatty acid metabolism_Homo sapiens_hsa012121.11003878
38Phenylalanine metabolism_Homo sapiens_hsa003601.10424862
39TGF-beta signaling pathway_Homo sapiens_hsa043501.10287496
40Circadian rhythm_Homo sapiens_hsa047101.05220264
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04029537
42beta-Alanine metabolism_Homo sapiens_hsa004101.00017039
43Chemical carcinogenesis_Homo sapiens_hsa052040.99097314
44Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95948484
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95146081
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94347964
47Proteoglycans in cancer_Homo sapiens_hsa052050.94310828
48Carbon metabolism_Homo sapiens_hsa012000.92544287
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92252685
50Melanoma_Homo sapiens_hsa052180.90137803
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88980166
52Adherens junction_Homo sapiens_hsa045200.86722808
53Galactose metabolism_Homo sapiens_hsa000520.85930498
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85522665
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.84264839
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84143156
57Dilated cardiomyopathy_Homo sapiens_hsa054140.83715332
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80361831
59Renin-angiotensin system_Homo sapiens_hsa046140.80299799
60Retinol metabolism_Homo sapiens_hsa008300.80153812
61RNA polymerase_Homo sapiens_hsa030200.78036059
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78002977
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77103377
64Cardiac muscle contraction_Homo sapiens_hsa042600.72377775
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70432769
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65246482
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65089538
68Fat digestion and absorption_Homo sapiens_hsa049750.62913693
69Malaria_Homo sapiens_hsa051440.62390047
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62136772
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61679748
72Basal transcription factors_Homo sapiens_hsa030220.60856680
73Nitrogen metabolism_Homo sapiens_hsa009100.60200888
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.59733575
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.58930453
76Metabolic pathways_Homo sapiens_hsa011000.57810898
77Arginine and proline metabolism_Homo sapiens_hsa003300.55189126
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54882569
79Fatty acid biosynthesis_Homo sapiens_hsa000610.54809749
80Starch and sucrose metabolism_Homo sapiens_hsa005000.54346908
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51304257
82Sphingolipid metabolism_Homo sapiens_hsa006000.50574472
83Pathways in cancer_Homo sapiens_hsa052000.48870744
84Small cell lung cancer_Homo sapiens_hsa052220.48788926
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47971969
86Ribosome_Homo sapiens_hsa030100.46304761
87Selenocompound metabolism_Homo sapiens_hsa004500.45696445
88Pyrimidine metabolism_Homo sapiens_hsa002400.43959173
89p53 signaling pathway_Homo sapiens_hsa041150.43781040
90Vibrio cholerae infection_Homo sapiens_hsa051100.41931191
91Basal cell carcinoma_Homo sapiens_hsa052170.41143672
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40395847
93AMPK signaling pathway_Homo sapiens_hsa041520.39464015
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38468376
95Amoebiasis_Homo sapiens_hsa051460.37206552
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.36875564
97Tight junction_Homo sapiens_hsa045300.36366915
98Steroid biosynthesis_Homo sapiens_hsa001000.36236629
99Pancreatic cancer_Homo sapiens_hsa052120.35541186
100Hippo signaling pathway_Homo sapiens_hsa043900.35192869

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