

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 7.12950309 |
| 2 | gonadal mesoderm development (GO:0007506) | 5.82166073 |
| 3 | response to peptidoglycan (GO:0032494) | 4.78275983 |
| 4 | neutrophil activation involved in immune response (GO:0002283) | 4.57841101 |
| 5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.14209699 |
| 6 | defense response to protozoan (GO:0042832) | 4.09796542 |
| 7 | regulation of meiosis I (GO:0060631) | 4.08459613 |
| 8 | immunoglobulin mediated immune response (GO:0016064) | 3.91198913 |
| 9 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.86978857 |
| 10 | positive regulation of mast cell degranulation (GO:0043306) | 3.86978857 |
| 11 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.86309424 |
| 12 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.86117577 |
| 13 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.86117577 |
| 14 | modulation by symbiont of host immune response (GO:0052553) | 3.85923399 |
| 15 | positive regulation by symbiont of host defense response (GO:0052509) | 3.85923399 |
| 16 | modulation by symbiont of host defense response (GO:0052031) | 3.85923399 |
| 17 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.85923399 |
| 18 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.85923399 |
| 19 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.85923399 |
| 20 | response to interferon-beta (GO:0035456) | 3.83253428 |
| 21 | response to protozoan (GO:0001562) | 3.82693722 |
| 22 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.69044537 |
| 23 | neutrophil activation (GO:0042119) | 3.65271281 |
| 24 | regulation of T cell tolerance induction (GO:0002664) | 3.59731659 |
| 25 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.49416335 |
| 26 | granulocyte activation (GO:0036230) | 3.40848449 |
| 27 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.40048390 |
| 28 | negative regulation of cell killing (GO:0031342) | 3.40048390 |
| 29 | B cell mediated immunity (GO:0019724) | 3.38159218 |
| 30 | regulation of tolerance induction (GO:0002643) | 3.35964290 |
| 31 | respiratory burst (GO:0045730) | 3.35218145 |
| 32 | detection of other organism (GO:0098543) | 3.30633715 |
| 33 | positive regulation of interferon-alpha production (GO:0032727) | 3.30433147 |
| 34 | response to interferon-alpha (GO:0035455) | 3.27645292 |
| 35 | cellular response to zinc ion (GO:0071294) | 3.27275526 |
| 36 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.26207443 |
| 37 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.23131011 |
| 38 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.20989721 |
| 39 | cellular response to type I interferon (GO:0071357) | 3.20756984 |
| 40 | type I interferon signaling pathway (GO:0060337) | 3.20756984 |
| 41 | response to type I interferon (GO:0034340) | 3.19489016 |
| 42 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.18859616 |
| 43 | detection of bacterium (GO:0016045) | 3.18753067 |
| 44 | regulation of interferon-alpha production (GO:0032647) | 3.18259569 |
| 45 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.18010478 |
| 46 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.17377442 |
| 47 | piRNA metabolic process (GO:0034587) | 3.17210227 |
| 48 | regulation of B cell differentiation (GO:0045577) | 3.16814672 |
| 49 | leukocyte aggregation (GO:0070486) | 3.13852773 |
| 50 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.12586310 |
| 51 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.12548866 |
| 52 | regulation of antigen processing and presentation (GO:0002577) | 3.11519234 |
| 53 | leukocyte degranulation (GO:0043299) | 3.10977169 |
| 54 | response to muramyl dipeptide (GO:0032495) | 3.08568401 |
| 55 | positive regulation of type 2 immune response (GO:0002830) | 3.06980604 |
| 56 | positive regulation of leukocyte degranulation (GO:0043302) | 3.06266661 |
| 57 | myeloid dendritic cell activation (GO:0001773) | 3.04614530 |
| 58 | T-helper 1 type immune response (GO:0042088) | 3.03422852 |
| 59 | negative regulation of phagocytosis (GO:0050765) | 3.02168734 |
| 60 | neutrophil mediated immunity (GO:0002446) | 2.99936526 |
| 61 | positive regulation of macrophage differentiation (GO:0045651) | 2.98986622 |
| 62 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.98769329 |
| 63 | regulation of chemokine biosynthetic process (GO:0045073) | 2.98258564 |
| 64 | positive regulation of B cell differentiation (GO:0045579) | 2.97969568 |
| 65 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.97134536 |
| 66 | ribosomal small subunit assembly (GO:0000028) | 2.95883519 |
| 67 | regulation of hypersensitivity (GO:0002883) | 2.93583761 |
| 68 | myeloid cell activation involved in immune response (GO:0002275) | 2.90441827 |
| 69 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.89820427 |
| 70 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.87743897 |
| 71 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.87669721 |
| 72 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.87029051 |
| 73 | negative regulation of viral genome replication (GO:0045071) | 2.86524631 |
| 74 | myeloid dendritic cell differentiation (GO:0043011) | 2.85415020 |
| 75 | regulation of mast cell activation (GO:0033003) | 2.84241384 |
| 76 | mast cell activation (GO:0045576) | 2.83214520 |
| 77 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.82809186 |
| 78 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.81232697 |
| 79 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.80846874 |
| 80 | macrophage activation involved in immune response (GO:0002281) | 2.80550526 |
| 81 | cellular response to interferon-beta (GO:0035458) | 2.80269152 |
| 82 | detection of molecule of bacterial origin (GO:0032490) | 2.79129700 |
| 83 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.77345482 |
| 84 | monocyte chemotaxis (GO:0002548) | 2.76926002 |
| 85 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.76795814 |
| 86 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.76276476 |
| 87 | positive regulation of interleukin-8 secretion (GO:2000484) | 2.76075391 |
| 88 | endosome to pigment granule transport (GO:0043485) | 2.75331108 |
| 89 | endosome to melanosome transport (GO:0035646) | 2.75331108 |
| 90 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.74554799 |
| 91 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.72932021 |
| 92 | actin nucleation (GO:0045010) | 2.70011416 |
| 93 | pyrimidine nucleoside salvage (GO:0043097) | 2.69836788 |
| 94 | pyrimidine-containing compound salvage (GO:0008655) | 2.69836788 |
| 95 | T cell migration (GO:0072678) | 2.69368087 |
| 96 | detection of external biotic stimulus (GO:0098581) | 2.69295451 |
| 97 | positive regulation of antigen processing and presentation (GO:0002579) | 2.69180000 |
| 98 | autophagic vacuole fusion (GO:0000046) | 2.68642517 |
| 99 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.68484567 |
| 100 | natural killer cell mediated immunity (GO:0002228) | 2.68484567 |
| 101 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.67833729 |
| 102 | mature B cell differentiation involved in immune response (GO:0002313) | 2.66824692 |
| 103 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.65890237 |
| 104 | B cell receptor signaling pathway (GO:0050853) | 2.65358913 |
| 105 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.65171386 |
| 106 | regulation of leukocyte degranulation (GO:0043300) | 2.64818271 |
| 107 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.64374412 |
| 108 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.64150295 |
| 109 | positive regulation of interleukin-10 production (GO:0032733) | 2.62825740 |
| 110 | mature B cell differentiation (GO:0002335) | 2.62686059 |
| 111 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.62361398 |
| 112 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.62109272 |
| 113 | interferon-gamma production (GO:0032609) | 2.61887712 |
| 114 | regulation of gamma-delta T cell activation (GO:0046643) | 2.61746249 |
| 115 | cellular extravasation (GO:0045123) | 2.61252277 |
| 116 | negative regulation of interleukin-17 production (GO:0032700) | 2.61129446 |
| 117 | nucleotide salvage (GO:0043173) | 2.60655145 |
| 118 | dendritic cell differentiation (GO:0097028) | 2.60555231 |
| 119 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.59101663 |
| 120 | T cell lineage commitment (GO:0002360) | 2.58815413 |
| 121 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.57659499 |
| 122 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.57496466 |
| 123 | positive regulation of interferon-beta production (GO:0032728) | 2.57275160 |
| 124 | phagocytosis, engulfment (GO:0006911) | 2.57219110 |
| 125 | myeloid leukocyte activation (GO:0002274) | 2.57108001 |
| 126 | folic acid transport (GO:0015884) | 2.57004372 |
| 127 | myeloid leukocyte mediated immunity (GO:0002444) | 2.56765861 |
| 128 | superoxide anion generation (GO:0042554) | 2.56515933 |
| 129 | T cell costimulation (GO:0031295) | 2.56295214 |
| 130 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.55991241 |
| 131 | response to host immune response (GO:0052572) | 2.55991241 |
| 132 | negative regulation of T cell mediated immunity (GO:0002710) | 2.55624038 |
| 133 | lymphocyte costimulation (GO:0031294) | 2.54310650 |
| 134 | positive regulation of protein import into nucleus, translocation (GO:0033160) | 2.54005804 |
| 135 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.53559505 |
| 136 | platelet dense granule organization (GO:0060155) | 2.53416734 |
| 137 | negative regulation of interleukin-12 production (GO:0032695) | 2.52838085 |
| 138 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.52371794 |
| 139 | regulation of RIG-I signaling pathway (GO:0039535) | 2.51843391 |
| 140 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.51338063 |
| 141 | negative thymic T cell selection (GO:0045060) | 2.50737873 |
| 142 | regulation of mast cell degranulation (GO:0043304) | 2.50314059 |
| 143 | positive regulation of interleukin-17 production (GO:0032740) | 2.49223603 |
| 144 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 2.49130009 |
| 145 | leukocyte mediated immunity (GO:0002443) | 2.48509540 |
| 146 | cellular response to interferon-gamma (GO:0071346) | 2.48462493 |
| 147 | positive regulation of mast cell activation (GO:0033005) | 2.48265535 |
| 148 | regulation of interleukin-17 production (GO:0032660) | 2.47956453 |
| 149 | organelle membrane fusion (GO:0090174) | 2.47010189 |
| 150 | regulation of cytokine secretion involved in immune response (GO:0002739) | 2.47003797 |
| 151 | positive regulation of B cell mediated immunity (GO:0002714) | 2.45964708 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.55864904 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.51491968 |
| 3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.63547077 |
| 4 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.53545170 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.98729079 |
| 6 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.55968799 |
| 7 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.55898827 |
| 8 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.21893151 |
| 9 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.09852170 |
| 10 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.05014551 |
| 11 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.01102552 |
| 12 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.00977201 |
| 13 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.97953570 |
| 14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.94156467 |
| 15 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.86501314 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.86152776 |
| 17 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.62643578 |
| 18 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.62346694 |
| 19 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.58433104 |
| 20 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.45436084 |
| 21 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.43152704 |
| 22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.40047081 |
| 23 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.27950679 |
| 24 | MYB_26560356_Chip-Seq_TH2_Human | 2.24406337 |
| 25 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.23105450 |
| 26 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 2.14375607 |
| 27 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 2.14375607 |
| 28 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 2.14375607 |
| 29 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.06772103 |
| 30 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.01641988 |
| 31 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.00970681 |
| 32 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.00803817 |
| 33 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.95080050 |
| 34 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.93217421 |
| 35 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.90769627 |
| 36 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.90363139 |
| 37 | MYB_26560356_Chip-Seq_TH1_Human | 1.86826267 |
| 38 | MAF_26560356_Chip-Seq_TH1_Human | 1.86459007 |
| 39 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.84670265 |
| 40 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.80749504 |
| 41 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70150958 |
| 42 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.63786028 |
| 43 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.61573520 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.60684074 |
| 45 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.54636746 |
| 46 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.52161985 |
| 47 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.51869454 |
| 48 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.51406024 |
| 49 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.50480583 |
| 50 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.49213896 |
| 51 | UTX_26944678_Chip-Seq_JUKART_Human | 1.47729914 |
| 52 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.46586858 |
| 53 | MYC_22102868_ChIP-Seq_BL_Human | 1.42437728 |
| 54 | GATA1_22025678_ChIP-Seq_K562_Human | 1.41659545 |
| 55 | SPI1_23127762_ChIP-Seq_K562_Human | 1.38923310 |
| 56 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.37899206 |
| 57 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35861850 |
| 58 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.35220053 |
| 59 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.33118777 |
| 60 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.28076719 |
| 61 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.27582292 |
| 62 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.27459715 |
| 63 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.26086671 |
| 64 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.22490821 |
| 65 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.19977282 |
| 66 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.19766214 |
| 67 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.19217461 |
| 68 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.18578603 |
| 69 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.13153122 |
| 70 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13148030 |
| 71 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.11351498 |
| 72 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.10594053 |
| 73 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.09458500 |
| 74 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.08915076 |
| 75 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07897519 |
| 76 | * GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.07083875 |
| 77 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.06632267 |
| 78 | MAF_26560356_Chip-Seq_TH2_Human | 1.05900977 |
| 79 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.03146356 |
| 80 | GATA3_26560356_Chip-Seq_TH2_Human | 1.01676734 |
| 81 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.99479646 |
| 82 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.98491508 |
| 83 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.98013562 |
| 84 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.97291954 |
| 85 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.96350658 |
| 86 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.96048194 |
| 87 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.96048194 |
| 88 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.95319605 |
| 89 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.95300679 |
| 90 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.93417604 |
| 91 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.93249587 |
| 92 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93213600 |
| 93 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.92336760 |
| 94 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.91602481 |
| 95 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.91306780 |
| 96 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89639655 |
| 97 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.89523753 |
| 98 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.87935302 |
| 99 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.87278885 |
| 100 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.86513893 |
| 101 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.84886897 |
| 102 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.84737343 |
| 103 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.81853629 |
| 104 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.80985659 |
| 105 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.80630549 |
| 106 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.79502756 |
| 107 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.79357857 |
| 108 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.78492253 |
| 109 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.78375162 |
| 110 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.77882198 |
| 111 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.76941535 |
| 112 | GATA3_26560356_Chip-Seq_TH1_Human | 0.76342789 |
| 113 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.76074562 |
| 114 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.75042153 |
| 115 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.74072047 |
| 116 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.73665858 |
| 117 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.73188941 |
| 118 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.72958119 |
| 119 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.72934447 |
| 120 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.72651474 |
| 121 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.72414917 |
| 122 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.71608773 |
| 123 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.70484442 |
| 124 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.70286931 |
| 125 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.69819234 |
| 126 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.69604660 |
| 127 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.69297716 |
| 128 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.69251854 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.28711497 |
| 2 | MP0009785_altered_susceptibility_to | 3.39524659 |
| 3 | MP0003436_decreased_susceptibility_to | 3.31398983 |
| 4 | MP0000685_abnormal_immune_system | 3.08560553 |
| 5 | MP0002148_abnormal_hypersensitivity_rea | 2.92310971 |
| 6 | MP0005671_abnormal_response_to | 2.91794520 |
| 7 | MP0005000_abnormal_immune_tolerance | 2.75678287 |
| 8 | MP0005387_immune_system_phenotype | 2.68675761 |
| 9 | MP0001790_abnormal_immune_system | 2.68675761 |
| 10 | MP0003806_abnormal_nucleotide_metabolis | 2.67990312 |
| 11 | MP0006082_CNS_inflammation | 2.65489528 |
| 12 | MP0002419_abnormal_innate_immunity | 2.63867048 |
| 13 | MP0005025_abnormal_response_to | 2.58648812 |
| 14 | MP0002452_abnormal_antigen_presenting | 2.58410784 |
| 15 | MP0001800_abnormal_humoral_immune | 2.58225038 |
| 16 | MP0003724_increased_susceptibility_to | 2.49021541 |
| 17 | MP0002723_abnormal_immune_serum | 2.34975030 |
| 18 | MP0008260_abnormal_autophagy | 2.33304611 |
| 19 | MP0002420_abnormal_adaptive_immunity | 2.30542819 |
| 20 | MP0001819_abnormal_immune_cell | 2.30177766 |
| 21 | MP0010368_abnormal_lymphatic_system | 2.17358246 |
| 22 | MP0002405_respiratory_system_inflammati | 2.07392362 |
| 23 | MP0010155_abnormal_intestine_physiology | 2.02055685 |
| 24 | MP0002396_abnormal_hematopoietic_system | 1.94553262 |
| 25 | MP0005464_abnormal_platelet_physiology | 1.94392178 |
| 26 | MP0003303_peritoneal_inflammation | 1.94334203 |
| 27 | MP0002166_altered_tumor_susceptibility | 1.91547037 |
| 28 | MP0002398_abnormal_bone_marrow | 1.91071399 |
| 29 | MP0005397_hematopoietic_system_phenotyp | 1.86719293 |
| 30 | MP0001545_abnormal_hematopoietic_system | 1.86719293 |
| 31 | MP0000716_abnormal_immune_system | 1.81889460 |
| 32 | MP0004808_abnormal_hematopoietic_stem | 1.81714946 |
| 33 | MP0001853_heart_inflammation | 1.81603915 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.80693123 |
| 35 | MP0001533_abnormal_skeleton_physiology | 1.79747229 |
| 36 | MP0002006_tumorigenesis | 1.78802628 |
| 37 | MP0004947_skin_inflammation | 1.76722726 |
| 38 | MP0008004_abnormal_stomach_pH | 1.76505827 |
| 39 | MP0000858_altered_metastatic_potential | 1.68955897 |
| 40 | MP0009333_abnormal_splenocyte_physiolog | 1.68676399 |
| 41 | MP0001845_abnormal_inflammatory_respons | 1.66721649 |
| 42 | MP0003183_abnormal_peptide_metabolism | 1.64458593 |
| 43 | MP0000689_abnormal_spleen_morphology | 1.63743617 |
| 44 | MP0002933_joint_inflammation | 1.56716715 |
| 45 | MP0002722_abnormal_immune_system | 1.55589410 |
| 46 | MP0002877_abnormal_melanocyte_morpholog | 1.54975803 |
| 47 | MP0000490_abnormal_crypts_of | 1.52490662 |
| 48 | MP0002429_abnormal_blood_cell | 1.51586714 |
| 49 | MP0000465_gastrointestinal_hemorrhage | 1.46396627 |
| 50 | MP0000343_altered_response_to | 1.42431009 |
| 51 | MP0005058_abnormal_lysosome_morphology | 1.38127093 |
| 52 | MP0005174_abnormal_tail_pigmentation | 1.37622435 |
| 53 | MP0009278_abnormal_bone_marrow | 1.36041094 |
| 54 | MP0003448_altered_tumor_morphology | 1.34904313 |
| 55 | MP0004510_myositis | 1.33998599 |
| 56 | MP0003300_gastrointestinal_ulcer | 1.33849261 |
| 57 | MP0003186_abnormal_redox_activity | 1.29943610 |
| 58 | MP0002132_abnormal_respiratory_system | 1.25450094 |
| 59 | MP0003279_aneurysm | 1.25421191 |
| 60 | MP0010352_gastrointestinal_tract_polyps | 1.24895611 |
| 61 | MP0002254_reproductive_system_inflammat | 1.21522169 |
| 62 | MP0002998_abnormal_bone_remodeling | 1.21263809 |
| 63 | MP0005451_abnormal_body_composition | 1.21116732 |
| 64 | MP0009764_decreased_sensitivity_to | 1.20838190 |
| 65 | MP0008469_abnormal_protein_level | 1.20241752 |
| 66 | MP0003828_pulmonary_edema | 1.20215323 |
| 67 | MP0009840_abnormal_foam_cell | 1.19556508 |
| 68 | MP0008438_abnormal_cutaneous_collagen | 1.16194205 |
| 69 | MP0005310_abnormal_salivary_gland | 1.16157242 |
| 70 | MP0005390_skeleton_phenotype | 1.15726121 |
| 71 | MP0003566_abnormal_cell_adhesion | 1.14703206 |
| 72 | MP0001873_stomach_inflammation | 1.12734221 |
| 73 | MP0008007_abnormal_cellular_replicative | 1.11510772 |
| 74 | MP0003191_abnormal_cellular_cholesterol | 1.11026253 |
| 75 | MP0003172_abnormal_lysosome_physiology | 1.11025271 |
| 76 | MP0000703_abnormal_thymus_morphology | 1.07017072 |
| 77 | MP0003866_abnormal_defecation | 1.01430213 |
| 78 | MP0005023_abnormal_wound_healing | 0.97745558 |
| 79 | MP0001851_eye_inflammation | 0.97115522 |
| 80 | MP0006054_spinal_hemorrhage | 0.94610702 |
| 81 | MP0002019_abnormal_tumor_incidence | 0.92084639 |
| 82 | MP0005166_decreased_susceptibility_to | 0.90987761 |
| 83 | MP0003656_abnormal_erythrocyte_physiolo | 0.89836559 |
| 84 | MP0008875_abnormal_xenobiotic_pharmacok | 0.89294002 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.88081393 |
| 86 | MP0000372_irregular_coat_pigmentation | 0.87150503 |
| 87 | MP0005164_abnormal_response_to | 0.86280776 |
| 88 | MP0010307_abnormal_tumor_latency | 0.86021862 |
| 89 | MP0005319_abnormal_enzyme/_coenzyme | 0.84825994 |
| 90 | MP0003075_altered_response_to | 0.84545673 |
| 91 | MP0005165_increased_susceptibility_to | 0.84147485 |
| 92 | MP0005076_abnormal_cell_differentiation | 0.82051667 |
| 93 | MP0002139_abnormal_hepatobiliary_system | 0.81989757 |
| 94 | MP0002277_abnormal_respiratory_mucosa | 0.81110592 |
| 95 | MP0002796_impaired_skin_barrier | 0.79566623 |
| 96 | MP0002009_preneoplasia | 0.77799432 |
| 97 | MP0005084_abnormal_gallbladder_morpholo | 0.77305763 |
| 98 | MP0002060_abnormal_skin_morphology | 0.74809697 |
| 99 | MP0005075_abnormal_melanosome_morpholog | 0.73510278 |
| 100 | MP0001958_emphysema | 0.72842153 |
| 101 | MP0009763_increased_sensitivity_to | 0.70782461 |
| 102 | MP0005647_abnormal_sex_gland | 0.70395804 |
| 103 | MP0005257_abnormal_intraocular_pressure | 0.69783601 |
| 104 | MP0003795_abnormal_bone_structure | 0.69603080 |
| 105 | MP0000767_abnormal_smooth_muscle | 0.68408162 |
| 106 | MP0000681_abnormal_thyroid_gland | 0.68243453 |
| 107 | MP0004782_abnormal_surfactant_physiolog | 0.68148480 |
| 108 | MP0002095_abnormal_skin_pigmentation | 0.67748088 |
| 109 | MP0001879_abnormal_lymphatic_vessel | 0.67525496 |
| 110 | MP0001986_abnormal_taste_sensitivity | 0.66901263 |
| 111 | MP0003453_abnormal_keratinocyte_physiol | 0.66227784 |
| 112 | MP0000249_abnormal_blood_vessel | 0.65458828 |
| 113 | MP0006036_abnormal_mitochondrial_physio | 0.65383182 |
| 114 | MP0001191_abnormal_skin_condition | 0.65107983 |
| 115 | MP0000015_abnormal_ear_pigmentation | 0.64897300 |
| 116 | MP0001346_abnormal_lacrimal_gland | 0.64802245 |
| 117 | MP0004883_abnormal_blood_vessel | 0.64196227 |
| 118 | MP0001542_abnormal_bone_strength | 0.64036128 |
| 119 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.63295351 |
| 120 | MP0003638_abnormal_response/metabolism_ | 0.62820911 |
| 121 | MP0004147_increased_porphyrin_level | 0.62781041 |
| 122 | MP0005365_abnormal_bile_salt | 0.62023576 |
| 123 | MP0005360_urolithiasis | 0.61550382 |
| 124 | MP0009643_abnormal_urine_homeostasis | 0.58099894 |
| 125 | MP0000604_amyloidosis | 0.57945058 |
| 126 | MP0001764_abnormal_homeostasis | 0.57892747 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 5.72665827 |
| 2 | Eczematoid dermatitis (HP:0000976) | 5.39434753 |
| 3 | Abnormality of glycolipid metabolism (HP:0010969) | 5.10887566 |
| 4 | Abnormality of liposaccharide metabolism (HP:0010968) | 5.10887566 |
| 5 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 5.10887566 |
| 6 | Myositis (HP:0100614) | 4.77908276 |
| 7 | Recurrent bacterial skin infections (HP:0005406) | 4.72067868 |
| 8 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.14355934 |
| 9 | Mediastinal lymphadenopathy (HP:0100721) | 4.07145686 |
| 10 | Abnormality of macrophages (HP:0004311) | 3.94022567 |
| 11 | Orchitis (HP:0100796) | 3.92509452 |
| 12 | Cellulitis (HP:0100658) | 3.78642012 |
| 13 | Retrobulbar optic neuritis (HP:0100654) | 3.72921285 |
| 14 | Optic neuritis (HP:0100653) | 3.72921285 |
| 15 | Recurrent fungal infections (HP:0002841) | 3.57711271 |
| 16 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.51945202 |
| 17 | Autoimmune thrombocytopenia (HP:0001973) | 3.43895632 |
| 18 | Chronic obstructive pulmonary disease (HP:0006510) | 3.36144944 |
| 19 | Obstructive lung disease (HP:0006536) | 3.36144944 |
| 20 | Dysostosis multiplex (HP:0000943) | 3.34689345 |
| 21 | Vacuolated lymphocytes (HP:0001922) | 3.32267762 |
| 22 | Meningitis (HP:0001287) | 3.26900870 |
| 23 | IgM deficiency (HP:0002850) | 3.19211543 |
| 24 | Recurrent skin infections (HP:0001581) | 3.16531811 |
| 25 | Vasculitis (HP:0002633) | 3.16283552 |
| 26 | Recurrent viral infections (HP:0004429) | 3.12132887 |
| 27 | Thrombocytosis (HP:0001894) | 3.03577504 |
| 28 | Agammaglobulinemia (HP:0004432) | 3.03161720 |
| 29 | Petechiae (HP:0000967) | 2.92725283 |
| 30 | Pustule (HP:0200039) | 2.91657983 |
| 31 | Systemic lupus erythematosus (HP:0002725) | 2.86067377 |
| 32 | Interstitial pulmonary disease (HP:0006530) | 2.84768708 |
| 33 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.81556763 |
| 34 | Increased cerebral lipofuscin (HP:0011813) | 2.78787019 |
| 35 | Recurrent pneumonia (HP:0006532) | 2.78461627 |
| 36 | Loss of speech (HP:0002371) | 2.78449665 |
| 37 | Recurrent cutaneous fungal infections (HP:0011370) | 2.76847110 |
| 38 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.76847110 |
| 39 | Gingivitis (HP:0000230) | 2.76441954 |
| 40 | Osteomyelitis (HP:0002754) | 2.74352516 |
| 41 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.73807353 |
| 42 | Inflammation of the large intestine (HP:0002037) | 2.73084325 |
| 43 | Abnormality of the costochondral junction (HP:0000919) | 2.70484573 |
| 44 | Abnormality of T cell physiology (HP:0011840) | 2.70122641 |
| 45 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.68013253 |
| 46 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.68013253 |
| 47 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.68013253 |
| 48 | Recurrent bronchitis (HP:0002837) | 2.67618161 |
| 49 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.67332218 |
| 50 | Mucopolysacchariduria (HP:0008155) | 2.67332218 |
| 51 | Prostate neoplasm (HP:0100787) | 2.67251738 |
| 52 | Chronic otitis media (HP:0000389) | 2.63845986 |
| 53 | Recurrent lower respiratory tract infections (HP:0002783) | 2.61910068 |
| 54 | Amyloidosis (HP:0011034) | 2.61730068 |
| 55 | Gastrointestinal inflammation (HP:0004386) | 2.57700492 |
| 56 | Periodontitis (HP:0000704) | 2.56165262 |
| 57 | Vertebral compression fractures (HP:0002953) | 2.54387640 |
| 58 | Hepatosplenomegaly (HP:0001433) | 2.53289067 |
| 59 | Abnormality of T cells (HP:0002843) | 2.52435249 |
| 60 | Hemoptysis (HP:0002105) | 2.52343655 |
| 61 | Purpura (HP:0000979) | 2.51813085 |
| 62 | Colitis (HP:0002583) | 2.46836554 |
| 63 | Facial diplegia (HP:0001349) | 2.45978853 |
| 64 | Stomatitis (HP:0010280) | 2.43680135 |
| 65 | Progressive neurologic deterioration (HP:0002344) | 2.43408227 |
| 66 | Pulmonary infiltrates (HP:0002113) | 2.43373834 |
| 67 | Prolonged bleeding time (HP:0003010) | 2.43312390 |
| 68 | Arterial thrombosis (HP:0004420) | 2.40096215 |
| 69 | Abnormality of T cell number (HP:0011839) | 2.38596490 |
| 70 | Abnormality of the prostate (HP:0008775) | 2.38435827 |
| 71 | Keratoconjunctivitis sicca (HP:0001097) | 2.36474881 |
| 72 | Episodic fever (HP:0001954) | 2.34122602 |
| 73 | Urticaria (HP:0001025) | 2.29484626 |
| 74 | Spontaneous hematomas (HP:0007420) | 2.28914404 |
| 75 | Osteolytic defects of the hand bones (HP:0009699) | 2.25514503 |
| 76 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.25514503 |
| 77 | Hypergammaglobulinemia (HP:0010702) | 2.17958453 |
| 78 | T lymphocytopenia (HP:0005403) | 2.15883852 |
| 79 | Gingival bleeding (HP:0000225) | 2.15556221 |
| 80 | Leukocytosis (HP:0001974) | 2.15253600 |
| 81 | Gonadal dysgenesis (HP:0000133) | 2.14495883 |
| 82 | Amaurosis fugax (HP:0100576) | 2.13586224 |
| 83 | Skin ulcer (HP:0200042) | 2.12626653 |
| 84 | Keratoconjunctivitis (HP:0001096) | 2.12297247 |
| 85 | Basal ganglia calcification (HP:0002135) | 2.12044001 |
| 86 | Abnormality of the pericardium (HP:0001697) | 2.10839196 |
| 87 | Hematochezia (HP:0002573) | 2.10412284 |
| 88 | Chronic diarrhea (HP:0002028) | 2.08333700 |
| 89 | Abnormality of the pleura (HP:0002103) | 2.08016878 |
| 90 | Polyneuropathy (HP:0001271) | 2.06370915 |
| 91 | IgG deficiency (HP:0004315) | 2.04817349 |
| 92 | Epistaxis (HP:0000421) | 2.04616863 |
| 93 | Chest pain (HP:0100749) | 2.04511171 |
| 94 | Sepsis (HP:0100806) | 2.04040818 |
| 95 | Disinhibition (HP:0000734) | 2.03217129 |
| 96 | Abnormality of the nasal mucosa (HP:0000433) | 2.03005590 |
| 97 | Increased IgM level (HP:0003496) | 2.02296345 |
| 98 | Mutism (HP:0002300) | 2.01611090 |
| 99 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.01466376 |
| 100 | Nasal polyposis (HP:0100582) | 2.00488663 |
| 101 | Lymphopenia (HP:0001888) | 2.00191385 |
| 102 | Panhypogammaglobulinemia (HP:0003139) | 1.99601182 |
| 103 | Cheilitis (HP:0100825) | 1.99096624 |
| 104 | Encephalitis (HP:0002383) | 1.98773251 |
| 105 | Eosinophilia (HP:0001880) | 1.97997975 |
| 106 | Gastrointestinal stroma tumor (HP:0100723) | 1.97050774 |
| 107 | Thyroiditis (HP:0100646) | 1.96903413 |
| 108 | Metaphyseal irregularity (HP:0003025) | 1.95902469 |
| 109 | Premature loss of primary teeth (HP:0006323) | 1.95673236 |
| 110 | Chronic sinusitis (HP:0011109) | 1.93181434 |
| 111 | Anorexia (HP:0002039) | 1.92995445 |
| 112 | Beaking of vertebral bodies (HP:0004568) | 1.92670362 |
| 113 | Glomerulopathy (HP:0100820) | 1.92663563 |
| 114 | Spondylolisthesis (HP:0003302) | 1.92447436 |
| 115 | Arthralgia (HP:0002829) | 1.92327887 |
| 116 | Increased IgE level (HP:0003212) | 1.90692779 |
| 117 | Increased serum ferritin (HP:0003281) | 1.90177646 |
| 118 | IgA deficiency (HP:0002720) | 1.90124525 |
| 119 | J-shaped sella turcica (HP:0002680) | 1.89962377 |
| 120 | Abnormality of B cell number (HP:0010975) | 1.89844830 |
| 121 | B lymphocytopenia (HP:0010976) | 1.89844830 |
| 122 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.89386399 |
| 123 | Gastrointestinal infarctions (HP:0005244) | 1.89259910 |
| 124 | Pulmonary fibrosis (HP:0002206) | 1.88484034 |
| 125 | Emphysema (HP:0002097) | 1.88199511 |
| 126 | Pulmonary embolism (HP:0002204) | 1.87879567 |
| 127 | Joint swelling (HP:0001386) | 1.87132213 |
| 128 | Autoimmune hemolytic anemia (HP:0001890) | 1.86224022 |
| 129 | Lymphoma (HP:0002665) | 1.85893646 |
| 130 | Gangrene (HP:0100758) | 1.84745194 |
| 131 | Granulocytopenia (HP:0001913) | 1.83401946 |
| 132 | Abnormality of eosinophils (HP:0001879) | 1.82235315 |
| 133 | Skin rash (HP:0000988) | 1.80403162 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 3.39639579 |
| 2 | IRAK4 | 3.08642129 |
| 3 | MAP3K14 | 3.08022760 |
| 4 | CDK19 | 2.84920992 |
| 5 | KIT | 2.77413870 |
| 6 | TBK1 | 2.71028009 |
| 7 | NME2 | 2.33974312 |
| 8 | IKBKE | 2.33065498 |
| 9 | TYK2 | 2.27789319 |
| 10 | BLK | 2.27390463 |
| 11 | TEC | 2.21154236 |
| 12 | JAK3 | 2.20408830 |
| 13 | PIM2 | 2.12881139 |
| 14 | TXK | 2.09801598 |
| 15 | IKBKB | 2.08349790 |
| 16 | IRAK3 | 2.03689740 |
| 17 | RIPK4 | 2.01542450 |
| 18 | BTK | 1.93754923 |
| 19 | FLT3 | 1.87506425 |
| 20 | ERN1 | 1.81410171 |
| 21 | ZAP70 | 1.74348288 |
| 22 | MAP2K3 | 1.69625628 |
| 23 | CSF1R | 1.68354353 |
| 24 | TGFBR1 | 1.64032924 |
| 25 | TRPM7 | 1.61778613 |
| 26 | SYK | 1.57460292 |
| 27 | MAP3K12 | 1.54150811 |
| 28 | TGFBR2 | 1.45475403 |
| 29 | MST4 | 1.45397175 |
| 30 | PBK | 1.44496531 |
| 31 | ARAF | 1.41291144 |
| 32 | STK10 | 1.35804811 |
| 33 | ZAK | 1.35228036 |
| 34 | NLK | 1.26895143 |
| 35 | JAK1 | 1.26006337 |
| 36 | PIM1 | 1.25845554 |
| 37 | TAOK2 | 1.24307348 |
| 38 | LCK | 1.18654926 |
| 39 | LRRK2 | 1.18344832 |
| 40 | RPS6KA4 | 1.17440627 |
| 41 | MATK | 1.17045831 |
| 42 | CHUK | 1.11886842 |
| 43 | BMPR1B | 1.10638188 |
| 44 | LIMK1 | 1.10460889 |
| 45 | ITK | 1.09882680 |
| 46 | MAP3K13 | 1.09672975 |
| 47 | ERBB3 | 1.09007935 |
| 48 | GRK7 | 1.07846263 |
| 49 | LYN | 1.07698356 |
| 50 | MAP3K1 | 1.06458763 |
| 51 | HCK | 1.04297050 |
| 52 | STK4 | 1.03489784 |
| 53 | CSK | 1.02967396 |
| 54 | MAP3K2 | 1.02895114 |
| 55 | RPS6KB2 | 1.00082507 |
| 56 | BCKDK | 0.98236903 |
| 57 | KSR2 | 0.97542835 |
| 58 | NEK9 | 0.94138993 |
| 59 | MAP3K3 | 0.93322848 |
| 60 | ABL2 | 0.91393501 |
| 61 | MAPKAPK3 | 0.88646199 |
| 62 | BMPR2 | 0.87836986 |
| 63 | FRK | 0.85848211 |
| 64 | ADRBK2 | 0.85328368 |
| 65 | CLK1 | 0.82093334 |
| 66 | IRAK1 | 0.80984201 |
| 67 | PRKCQ | 0.78984196 |
| 68 | CDK8 | 0.77861680 |
| 69 | EPHB1 | 0.77624639 |
| 70 | PRPF4B | 0.77505701 |
| 71 | NUAK1 | 0.75491758 |
| 72 | RAF1 | 0.75116273 |
| 73 | TAOK1 | 0.74705667 |
| 74 | EEF2K | 0.72629380 |
| 75 | TIE1 | 0.72504771 |
| 76 | EIF2AK3 | 0.72170688 |
| 77 | MOS | 0.71087086 |
| 78 | TESK1 | 0.69568457 |
| 79 | FGFR3 | 0.68665722 |
| 80 | SCYL2 | 0.67199666 |
| 81 | CDK6 | 0.66396111 |
| 82 | TNK2 | 0.66086759 |
| 83 | GRK6 | 0.65058400 |
| 84 | PAK4 | 0.64700154 |
| 85 | PRKG2 | 0.63054383 |
| 86 | IRAK2 | 0.62821446 |
| 87 | RIPK1 | 0.61297980 |
| 88 | MAP3K11 | 0.61171032 |
| 89 | FES | 0.61046368 |
| 90 | KDR | 0.59944861 |
| 91 | TAOK3 | 0.59911430 |
| 92 | FGR | 0.59612022 |
| 93 | RPS6KA6 | 0.58476029 |
| 94 | MAPKAPK2 | 0.57516274 |
| 95 | EPHA3 | 0.57409925 |
| 96 | PRKCD | 0.57006332 |
| 97 | TESK2 | 0.56629780 |
| 98 | EGFR | 0.54843185 |
| 99 | TRIM28 | 0.54711022 |
| 100 | PIK3CG | 0.54167914 |
| 101 | PKN2 | 0.53264037 |
| 102 | BUB1 | 0.53172641 |
| 103 | ACVR1B | 0.51855409 |
| 104 | SIK3 | 0.50170044 |
| 105 | NEK6 | 0.49809336 |
| 106 | YES1 | 0.48640924 |
| 107 | STK24 | 0.48107932 |
| 108 | ABL1 | 0.47639469 |
| 109 | MAPKAPK5 | 0.47549438 |
| 110 | JAK2 | 0.46405473 |
| 111 | MAP3K10 | 0.46039529 |
| 112 | RPS6KC1 | 0.45702752 |
| 113 | RPS6KL1 | 0.45702752 |
| 114 | IGF1R | 0.45381094 |
| 115 | DAPK1 | 0.45284804 |
| 116 | HIPK2 | 0.43395959 |
| 117 | ILK | 0.42377072 |
| 118 | EIF2AK2 | 0.40728376 |
| 119 | VRK1 | 0.40496176 |
| 120 | MYLK | 0.39584021 |
| 121 | INSR | 0.39514495 |
| 122 | PDK1 | 0.39018725 |
| 123 | FGFR4 | 0.38502417 |
| 124 | FYN | 0.37148234 |
| 125 | MARK3 | 0.35990181 |
| 126 | TNIK | 0.35621019 |
| 127 | CDK9 | 0.33925964 |
| 128 | MAP2K2 | 0.32799724 |
| 129 | PRKD2 | 0.32409304 |
| 130 | PAK1 | 0.28323338 |
| 131 | CDK4 | 0.27572460 |
| 132 | MAP3K5 | 0.25417378 |
| 133 | PDPK1 | 0.24670758 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 2.76019610 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.71433181 |
| 3 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.52903709 |
| 4 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.35843048 |
| 5 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.22995988 |
| 6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.21557975 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.20138160 |
| 8 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.17721516 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.14929278 |
| 10 | Malaria_Homo sapiens_hsa05144 | 2.05798680 |
| 11 | Measles_Homo sapiens_hsa05162 | 2.02565611 |
| 12 | Legionellosis_Homo sapiens_hsa05134 | 1.96250341 |
| 13 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.89220886 |
| 14 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.88408078 |
| 15 | Pertussis_Homo sapiens_hsa05133 | 1.84614344 |
| 16 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.80990855 |
| 17 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.76298094 |
| 18 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.73225720 |
| 19 | Tuberculosis_Homo sapiens_hsa05152 | 1.65257504 |
| 20 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.63900233 |
| 21 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.59187052 |
| 22 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.54053642 |
| 23 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.49670949 |
| 24 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.47984908 |
| 25 | Shigellosis_Homo sapiens_hsa05131 | 1.47636111 |
| 26 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.47185672 |
| 27 | Asthma_Homo sapiens_hsa05310 | 1.46699729 |
| 28 | Influenza A_Homo sapiens_hsa05164 | 1.43244379 |
| 29 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.42636168 |
| 30 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.42317031 |
| 31 | Apoptosis_Homo sapiens_hsa04210 | 1.40173525 |
| 32 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.38828342 |
| 33 | Salmonella infection_Homo sapiens_hsa05132 | 1.37636563 |
| 34 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.36530173 |
| 35 | Other glycan degradation_Homo sapiens_hsa00511 | 1.33299865 |
| 36 | Base excision repair_Homo sapiens_hsa03410 | 1.29575937 |
| 37 | Ribosome_Homo sapiens_hsa03010 | 1.28629586 |
| 38 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.26857455 |
| 39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.26274091 |
| 40 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.25497055 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.23071746 |
| 42 | Lysosome_Homo sapiens_hsa04142 | 1.20720523 |
| 43 | DNA replication_Homo sapiens_hsa03030 | 1.19482424 |
| 44 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.18239390 |
| 45 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.17289639 |
| 46 | Phagosome_Homo sapiens_hsa04145 | 1.16230222 |
| 47 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.15024402 |
| 48 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.13033169 |
| 49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.05513966 |
| 50 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.03175106 |
| 51 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.02083820 |
| 52 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.01963227 |
| 53 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.01854319 |
| 54 | Viral myocarditis_Homo sapiens_hsa05416 | 0.97415618 |
| 55 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.97086017 |
| 56 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.96594715 |
| 57 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.96359165 |
| 58 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.94854359 |
| 59 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.88009124 |
| 60 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.83576366 |
| 61 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.81945589 |
| 62 | Platelet activation_Homo sapiens_hsa04611 | 0.81903482 |
| 63 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.80609364 |
| 64 | Homologous recombination_Homo sapiens_hsa03440 | 0.77881736 |
| 65 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.76999950 |
| 66 | Hepatitis C_Homo sapiens_hsa05160 | 0.76855847 |
| 67 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.74855031 |
| 68 | Mismatch repair_Homo sapiens_hsa03430 | 0.73225836 |
| 69 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.72346010 |
| 70 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.71815229 |
| 71 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.71212916 |
| 72 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.70006001 |
| 73 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.69958660 |
| 74 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.69375265 |
| 75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.67057759 |
| 76 | HTLV-I infection_Homo sapiens_hsa05166 | 0.66446892 |
| 77 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.65618271 |
| 78 | Proteasome_Homo sapiens_hsa03050 | 0.64035098 |
| 79 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.63098758 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62213769 |
| 81 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.61965852 |
| 82 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.59032975 |
| 83 | Amoebiasis_Homo sapiens_hsa05146 | 0.57403622 |
| 84 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.56331272 |
| 85 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.55401696 |
| 86 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.53198595 |
| 87 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.52950363 |
| 88 | Endocytosis_Homo sapiens_hsa04144 | 0.52349919 |
| 89 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.51526971 |
| 90 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.50072693 |
| 91 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.48060350 |
| 92 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.47732837 |
| 93 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.43732221 |
| 94 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43552113 |
| 95 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.42356550 |
| 96 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41337798 |
| 97 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.41034484 |
| 98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.40667471 |
| 99 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39914223 |
| 100 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39704443 |
| 101 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.39084407 |
| 102 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38930418 |
| 103 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.38479630 |
| 104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.37802947 |
| 105 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.35788740 |
| 106 | Galactose metabolism_Homo sapiens_hsa00052 | 0.35230454 |
| 107 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.33501274 |
| 108 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.32572640 |
| 109 | Cell cycle_Homo sapiens_hsa04110 | 0.31673459 |
| 110 | Thyroid cancer_Homo sapiens_hsa05216 | 0.31531750 |
| 111 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.30848110 |
| 112 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29450322 |
| 113 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.28486815 |
| 114 | Colorectal cancer_Homo sapiens_hsa05210 | 0.27446898 |
| 115 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.26981481 |
| 116 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.21957096 |
| 117 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.21511597 |
| 118 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.16827081 |
| 119 | Peroxisome_Homo sapiens_hsa04146 | 0.11807832 |
| 120 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.11334692 |
| 121 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.10396334 |

