PRAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)9.95279638
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060528.71254884
3fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)7.10229759
4epithelial cell maturation (GO:0002070)6.61296101
5biotin metabolic process (GO:0006768)5.71082617
6regulation of receptor binding (GO:1900120)5.66111777
7prostate gland epithelium morphogenesis (GO:0060740)5.55642339
8response to testosterone (GO:0033574)5.12816182
9positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.99654958
10iron ion import (GO:0097286)4.97530385
11intestinal epithelial cell development (GO:0060576)4.92505063
12regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.92471368
13artery development (GO:0060840)4.48646337
14positive regulation of histone deacetylation (GO:0031065)4.37426777
15carnitine shuttle (GO:0006853)4.16538190
16protein retention in ER lumen (GO:0006621)4.15651425
17mitotic cell cycle arrest (GO:0071850)4.14862357
18viral transcription (GO:0019083)4.10346493
19regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.00305746
20negative regulation of stress fiber assembly (GO:0051497)4.00232440
21ribosomal small subunit biogenesis (GO:0042274)3.98879031
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91955089
23insulin-like growth factor receptor signaling pathway (GO:0048009)3.88521651
24ribosomal small subunit assembly (GO:0000028)3.85866455
25translational termination (GO:0006415)3.85345061
26peptidyl-proline hydroxylation (GO:0019511)3.83036602
27positive regulation of cellular amine metabolic process (GO:0033240)3.76010910
28COPI coating of Golgi vesicle (GO:0048205)3.72002017
29Golgi transport vesicle coating (GO:0048200)3.72002017
30desmosome organization (GO:0002934)3.71351549
31glutathione biosynthetic process (GO:0006750)3.70696005
32negative regulation of glycogen biosynthetic process (GO:0045719)3.68569489
33positive regulation of protein deacetylation (GO:0090312)3.65908058
34pharyngeal system development (GO:0060037)3.48745530
35viral life cycle (GO:0019058)3.47465667
36translational elongation (GO:0006414)3.44079449
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42469273
38protein targeting to ER (GO:0045047)3.39918781
39positive regulation of steroid hormone secretion (GO:2000833)3.38143924
40cotranslational protein targeting to membrane (GO:0006613)3.37649355
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.33281998
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30690624
43opsonization (GO:0008228)3.29688781
44positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.28186612
45carnitine transmembrane transport (GO:1902603)3.27752022
46regulation of fatty acid beta-oxidation (GO:0031998)3.25620594
47nonribosomal peptide biosynthetic process (GO:0019184)3.24972016
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24511734
49maternal placenta development (GO:0001893)3.24167841
50endothelial cell chemotaxis (GO:0035767)3.23188422
51protein localization to endoplasmic reticulum (GO:0070972)3.19494290
52peptidyl-tyrosine autophosphorylation (GO:0038083)3.16136933
53muscle organ morphogenesis (GO:0048644)3.15687869
54endocrine hormone secretion (GO:0060986)3.15461803
55negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.12208043
56auditory receptor cell differentiation (GO:0042491)3.10814886
57fatty acid transmembrane transport (GO:1902001)3.10475672
58dorsal/ventral neural tube patterning (GO:0021904)3.09478980
59protein autoprocessing (GO:0016540)3.09292959
60positive regulation by host of viral transcription (GO:0043923)3.05922790
61negative regulation of epithelial to mesenchymal transition (GO:0010719)3.05882969
62coronary vasculature morphogenesis (GO:0060977)3.03654194
63epithelial cell differentiation involved in prostate gland development (GO:0060742)3.00817200
64translational initiation (GO:0006413)2.90179447
65negative regulation of potassium ion transmembrane transport (GO:1901380)2.89818343
66cellular protein complex disassembly (GO:0043624)2.89697980
67carnitine transport (GO:0015879)2.88539766
68amino-acid betaine transport (GO:0015838)2.88539766
69negative regulation of focal adhesion assembly (GO:0051895)2.87199978
70negative regulation of cell junction assembly (GO:1901889)2.87199978
71negative regulation of adherens junction organization (GO:1903392)2.87199978
72sodium ion homeostasis (GO:0055078)2.85709458
73polyamine biosynthetic process (GO:0006596)2.85032268
74sex differentiation (GO:0007548)2.84822410
75purine nucleoside diphosphate metabolic process (GO:0009135)2.83255253
76purine ribonucleoside diphosphate metabolic process (GO:0009179)2.83255253
77sensory perception of taste (GO:0050909)2.82586976
78androgen receptor signaling pathway (GO:0030521)2.82243473
79regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.80956255
80import into cell (GO:0098657)2.80852495
81bile acid biosynthetic process (GO:0006699)2.80137522
82lung epithelial cell differentiation (GO:0060487)2.79846337
83regulation of transcription from RNA polymerase III promoter (GO:0006359)2.79034392
84negative regulation of actin filament bundle assembly (GO:0032232)2.76602477
85peptide biosynthetic process (GO:0043043)2.76356624
864-hydroxyproline metabolic process (GO:0019471)2.76243182
87positive regulation of T cell cytokine production (GO:0002726)2.76212521
88negative regulation of cell size (GO:0045792)2.74787687
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73951260
90negative regulation of fatty acid biosynthetic process (GO:0045717)2.73415706
91negative regulation of glycogen metabolic process (GO:0070874)2.71881310
92bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71535709
93lung cell differentiation (GO:0060479)2.71509274
94ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.70373617
95nucleoside bisphosphate biosynthetic process (GO:0033866)2.70373617
96purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.70373617
97negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68007654
98water homeostasis (GO:0030104)2.67930050
99ribonucleoside diphosphate metabolic process (GO:0009185)2.65921054
100positive regulation of prostaglandin secretion (GO:0032308)2.65502000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21909140_ChIP-Seq_LNCAP_Human4.91238059
2HIF1A_21447827_ChIP-Seq_MCF-7_Human3.91732605
3CHD1_26751641_Chip-Seq_LNCaP_Human3.57507083
4PIAS1_25552417_ChIP-Seq_VCAP_Human3.48613049
5FOXA1_25552417_ChIP-Seq_VCAP_Human3.17113262
6FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.16793657
7AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.99846306
8ZNF263_19887448_ChIP-Seq_K562_Human2.74223331
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.68899643
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.43520178
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.43520178
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.43520178
13RACK7_27058665_Chip-Seq_MCF-7_Human2.34408522
14CREB1_26743006_Chip-Seq_LNCaP_Human2.23432141
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06389640
16ERG_21242973_ChIP-ChIP_JURKAT_Human1.95364693
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94817481
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90251050
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85524178
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83162830
21LXR_22292898_ChIP-Seq_THP-1_Human1.83032030
22CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.82588734
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80508123
24AR_21572438_ChIP-Seq_LNCaP_Human1.77293288
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72415213
26KDM5A_27292631_Chip-Seq_BREAST_Human1.69108507
27MYC_22102868_ChIP-Seq_BL_Human1.67425332
28ELF5_23300383_ChIP-Seq_T47D_Human1.62953952
29GATA6_25053715_ChIP-Seq_YYC3_Human1.61209879
30VDR_21846776_ChIP-Seq_THP-1_Human1.57694620
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56766797
32ATF3_27146783_Chip-Seq_COLON_Human1.56453222
33IGF1R_20145208_ChIP-Seq_DFB_Human1.47331263
34P68_20966046_ChIP-Seq_HELA_Human1.46603188
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.46005112
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.45490112
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44279470
38XRN2_22483619_ChIP-Seq_HELA_Human1.44262377
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43706442
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41282074
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40453643
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40344471
43FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.37904964
44SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37871360
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36868535
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35226174
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.34809876
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30690285
49TCF7_22412390_ChIP-Seq_EML_Mouse1.29416570
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27484214
51CLOCK_20551151_ChIP-Seq_293T_Human1.27215710
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26627831
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26552830
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.26130610
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22869894
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22431359
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22174917
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.21494899
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18724943
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18404192
61SMC4_20622854_ChIP-Seq_HELA_Human1.17395913
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.16998731
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16554084
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.16258818
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16132993
66RARB_24833708_ChIP-Seq_LIVER_Mouse1.15204407
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14553482
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.14452698
69TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.14355212
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12389705
71ERG_20517297_ChIP-Seq_VCAP_Human1.11609363
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09958400
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.09691572
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09004745
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08644027
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08077682
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07253516
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.07211932
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07041428
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05729391
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02163772
82GABP_19822575_ChIP-Seq_HepG2_Human1.00726301
83GATA4_25053715_ChIP-Seq_YYC3_Human1.00350630
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00268398
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00102180
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.99538850
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98058046
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96719302
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96443558
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94093880
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92699239
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92003868
93CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91910730
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91174398
95MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90663214
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.90017016
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89448206
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.88916222
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88793930
100BCOR_27268052_Chip-Seq_Bcells_Human0.88108926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia6.40298200
2MP0000537_abnormal_urethra_morphology5.76498958
3MP0002166_altered_tumor_susceptibility4.56966304
4MP0003315_abnormal_perineum_morphology4.53288524
5MP0004858_abnormal_nervous_system4.47006779
6MP0010234_abnormal_vibrissa_follicle4.33594431
7MP0004145_abnormal_muscle_electrophysio3.58442668
8MP0004043_abnormal_pH_regulation3.54383760
9MP0002006_tumorigenesis3.47746943
10MP0005451_abnormal_body_composition3.12070593
11MP0002822_catalepsy2.96909756
12MP0005310_abnormal_salivary_gland2.84802743
13MP0002234_abnormal_pharynx_morphology2.66269760
14MP0005647_abnormal_sex_gland2.43264469
15MP0005085_abnormal_gallbladder_physiolo2.37446631
16MP0005670_abnormal_white_adipose2.36234857
17MP0005666_abnormal_adipose_tissue1.94225704
18MP0003879_abnormal_hair_cell1.93341001
19MP0002909_abnormal_adrenal_gland1.89971503
20MP0000516_abnormal_urinary_system1.87908252
21MP0005367_renal/urinary_system_phenotyp1.87908252
22MP0000538_abnormal_urinary_bladder1.75473844
23MP0001765_abnormal_ion_homeostasis1.74187857
24MP0003705_abnormal_hypodermis_morpholog1.61683595
25MP0008961_abnormal_basal_metabolism1.58249597
26MP0002277_abnormal_respiratory_mucosa1.56050690
27MP0003123_paternal_imprinting1.54298975
28MP0005636_abnormal_mineral_homeostasis1.52620736
29MP0001873_stomach_inflammation1.49439984
30MP0001919_abnormal_reproductive_system1.47309504
31MP0000613_abnormal_salivary_gland1.45594937
32MP0000678_abnormal_parathyroid_gland1.42748961
33MP0005220_abnormal_exocrine_pancreas1.40824115
34MP0005645_abnormal_hypothalamus_physiol1.39831761
35MP0005187_abnormal_penis_morphology1.37389623
36MP0004264_abnormal_extraembryonic_tissu1.34496096
37MP0002876_abnormal_thyroid_physiology1.30203798
38MP0004185_abnormal_adipocyte_glucose1.28419406
39MP0000627_abnormal_mammary_gland1.15530758
40MP0000534_abnormal_ureter_morphology1.13908554
41MP0005076_abnormal_cell_differentiation1.10559365
42MP0003011_delayed_dark_adaptation1.05695153
43MP0005375_adipose_tissue_phenotype1.04399141
44MP0000230_abnormal_systemic_arterial1.03926618
45MP0009379_abnormal_foot_pigmentation1.01463597
46MP0000747_muscle_weakness0.95870167
47MP0003868_abnormal_feces_composition0.94662868
48MP0003283_abnormal_digestive_organ0.92860323
49MP0009053_abnormal_anal_canal0.90015014
50MP0001485_abnormal_pinna_reflex0.89560955
51MP0004036_abnormal_muscle_relaxation0.82540646
52MP0005083_abnormal_biliary_tract0.78731017
53MP0005646_abnormal_pituitary_gland0.78546790
54MP0001756_abnormal_urination0.77624657
55MP0001944_abnormal_pancreas_morphology0.77127399
56MP0008260_abnormal_autophagy0.75292203
57MP0004019_abnormal_vitamin_homeostasis0.74573900
58MP0001666_abnormal_nutrient_absorption0.72746198
59MP0004947_skin_inflammation0.69617529
60MP0002160_abnormal_reproductive_system0.69574704
61MP0005365_abnormal_bile_salt0.69013232
62MP0000566_synostosis0.68814619
63MP0002249_abnormal_larynx_morphology0.67954503
64MP0001730_embryonic_growth_arrest0.66823641
65MP0003953_abnormal_hormone_level0.65545953
66MP0000955_abnormal_spinal_cord0.65282708
67MP0001664_abnormal_digestion0.65125096
68MP0003936_abnormal_reproductive_system0.64653067
69MP0002557_abnormal_social/conspecific_i0.64544131
70MP0001764_abnormal_homeostasis0.63911458
71MP0002163_abnormal_gland_morphology0.63532601
72MP0002735_abnormal_chemical_nociception0.63455195
73MP0002796_impaired_skin_barrier0.63375588
74MP0001879_abnormal_lymphatic_vessel0.62985350
75MP0004510_myositis0.62039724
76MP0000477_abnormal_intestine_morphology0.61306743
77MP0002089_abnormal_postnatal_growth/wei0.60916702
78MP0001502_abnormal_circadian_rhythm0.59545994
79MP0003693_abnormal_embryo_hatching0.57744026
80MP0009643_abnormal_urine_homeostasis0.55748751
81MP0002693_abnormal_pancreas_physiology0.54677472
82MP0001145_abnormal_male_reproductive0.54040090
83MP0003698_abnormal_male_reproductive0.53837946
84MP0003937_abnormal_limbs/digits/tail_de0.51436925
85MP0002111_abnormal_tail_morphology0.50404261
86MP0001881_abnormal_mammary_gland0.48853221
87MP0002118_abnormal_lipid_homeostasis0.48540046
88MP0003984_embryonic_growth_retardation0.48233612
89MP0001663_abnormal_digestive_system0.47295059
90MP0003942_abnormal_urinary_system0.47172432
91MP0000733_abnormal_muscle_development0.46996953
92MP0002078_abnormal_glucose_homeostasis0.46173612
93MP0003890_abnormal_embryonic-extraembry0.46031081
94MP0002088_abnormal_embryonic_growth/wei0.45590922
95MP0001216_abnormal_epidermal_layer0.44426469
96MP0005319_abnormal_enzyme/_coenzyme0.44421424
97MP0001348_abnormal_lacrimal_gland0.44221693
98MP0005448_abnormal_energy_balance0.43378598
99MP0002734_abnormal_mechanical_nocicepti0.42773717
100MP0001672_abnormal_embryogenesis/_devel0.42347101

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.34380712
2Decreased circulating renin level (HP:0003351)6.89428436
3Testicular atrophy (HP:0000029)5.84567841
4Intrahepatic cholestasis (HP:0001406)5.44522423
5Abnormality of the axillary hair (HP:0100134)5.43030668
6Abnormality of secondary sexual hair (HP:0009888)5.43030668
7Gonadotropin excess (HP:0000837)5.06797341
8Prostate neoplasm (HP:0100787)4.99898566
9Calf muscle hypertrophy (HP:0008981)4.59772412
10Hyperkalemia (HP:0002153)4.52303907
11Flat acetabular roof (HP:0003180)4.41811920
12Abnormal tarsal ossification (HP:0008369)4.23898142
13Sensorimotor neuropathy (HP:0007141)4.20050178
14Chronic bronchitis (HP:0004469)4.17158583
15Abnormality of the 1st metacarpal (HP:0010009)4.16530939
16Flattened epiphyses (HP:0003071)4.12630029
17Muscle hypertrophy of the lower extremities (HP:0008968)4.07948255
18Abnormality of renin-angiotensin system (HP:0000847)3.87870904
19Hyperaldosteronism (HP:0000859)3.86786696
20Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.81550604
21Short 1st metacarpal (HP:0010034)3.81550604
22Abnormality of chloride homeostasis (HP:0011422)3.76021429
23Hyponatremia (HP:0002902)3.71992360
24Azoospermia (HP:0000027)3.67131582
25Renal salt wasting (HP:0000127)3.65360332
26Hypokalemic alkalosis (HP:0001949)3.47256884
27Prolonged neonatal jaundice (HP:0006579)3.42515888
28Testicular neoplasm (HP:0010788)3.41467089
29Sparse lateral eyebrow (HP:0005338)3.32688508
30Short phalanx of the thumb (HP:0009660)3.19355455
31Abnormality of the distal phalanx of the thumb (HP:0009617)3.18839404
32Microretrognathia (HP:0000308)3.12723669
33Abnormality of the phalanges of the hallux (HP:0010057)3.11213719
34Abnormality of carpal bone ossification (HP:0006257)3.04946073
35Multiple enchondromatosis (HP:0005701)2.92158044
36Glossoptosis (HP:0000162)2.85486558
37Bifid scrotum (HP:0000048)2.73318436
38Alkalosis (HP:0001948)2.66870682
39Seborrheic dermatitis (HP:0001051)2.66042744
40Abnormal spermatogenesis (HP:0008669)2.65103227
41Adrenal overactivity (HP:0002717)2.61577785
42Abnormal foot bone ossification (HP:0010675)2.61511784
43Hypokalemia (HP:0002900)2.60437431
44Amelogenesis imperfecta (HP:0000705)2.56678211
45Abnormal cartilage morphology (HP:0002763)2.51928097
46Abnormality of the parathyroid morphology (HP:0011766)2.51453930
47Abnormality of sodium homeostasis (HP:0010931)2.47385118
48Abnormal hand bone ossification (HP:0010660)2.45254346
49Bulbar palsy (HP:0001283)2.43046784
50Lower limb hyperreflexia (HP:0002395)2.41899730
51Hyperthyroidism (HP:0000836)2.40448215
52Growth hormone excess (HP:0000845)2.32542500
53Abnormal ossification of hand bones (HP:0005921)2.31812771
54Fat malabsorption (HP:0002630)2.31437342
55Hyperpituitarism (HP:0010514)2.31347390
56Abnormality of the distal phalanges of the toes (HP:0010182)2.30083799
57Abnormality of the prostate (HP:0008775)2.29665611
58Septate vagina (HP:0001153)2.28444640
59Abnormality of potassium homeostasis (HP:0011042)2.22876350
60Congenital glaucoma (HP:0001087)2.22267670
61Neonatal onset (HP:0003623)2.21805347
62Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.21295597
63Deep venous thrombosis (HP:0002625)2.19961588
64Abnormality of the proximal phalanges of the hand (HP:0009834)2.19227843
65Urethral obstruction (HP:0000796)2.19022673
66Neonatal hypoglycemia (HP:0001998)2.17238027
67Dysmetric saccades (HP:0000641)2.09255207
6811 pairs of ribs (HP:0000878)2.08446797
69Right ventricular cardiomyopathy (HP:0011663)2.08349872
70Aplastic anemia (HP:0001915)2.01791269
71Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.00682384
72Lip pit (HP:0100267)1.99548296
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99509354
74Abnormality of the gallbladder (HP:0005264)1.97319325
75Anal stenosis (HP:0002025)1.96471697
76Genu varum (HP:0002970)1.95924682
77Absent hair (HP:0002298)1.93708077
78Germ cell neoplasia (HP:0100728)1.92309335
79Short humerus (HP:0005792)1.91171528
80Abnormality of cells of the erythroid lineage (HP:0012130)1.90147225
81Obstructive sleep apnea (HP:0002870)1.89013596
82Aplasia/hypoplasia of the femur (HP:0005613)1.88344564
83Primary adrenal insufficiency (HP:0008207)1.88176454
84Spinal cord compression (HP:0002176)1.85059672
85Hypokinesia (HP:0002375)1.84204736
86Popliteal pterygium (HP:0009756)1.79908118
87Abnormally folded helix (HP:0008544)1.76708523
88Dysdiadochokinesis (HP:0002075)1.75843108
89Abnormality of the aortic arch (HP:0012303)1.74523288
90Ketoacidosis (HP:0001993)1.74375540
91Abnormality of male internal genitalia (HP:0000022)1.73403580
92Partial duplication of thumb phalanx (HP:0009944)1.71715357
93Aplasia/hypoplasia of the humerus (HP:0006507)1.71705253
94Advanced eruption of teeth (HP:0006288)1.71280049
95Axonal loss (HP:0003447)1.69804154
96Metabolic acidosis (HP:0001942)1.67318542
97Abnormality of proline metabolism (HP:0010907)1.65266808
98Hydroxyprolinuria (HP:0003080)1.65266808
99Broad face (HP:0000283)1.65096193
100Blue sclerae (HP:0000592)1.64586503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK25.84462854
2AKT34.87064709
3CAMK1D4.79130269
4PRKD34.54225023
5STK393.75801663
6CAMK1G3.63147047
7EEF2K3.39743932
8TAOK13.00152496
9TRIB32.78793036
10WNK42.72258839
11NME22.58649831
12FER2.52694977
13ARAF2.51358553
14PIM22.39625735
15SMG12.28991614
16PKN22.09360657
17SIK12.07739633
18EPHA21.82641519
19PRKD21.62884852
20IRAK31.62606605
21SCYL21.60560906
22TESK11.58333401
23LMTK21.57053758
24TESK21.50820790
25CAMKK21.44996221
26MARK21.35669002
27PRKCI1.24149953
28MAP3K131.22971527
29BRAF1.11664746
30IRAK21.10699438
31ERN11.02166264
32MAPKAPK30.98166958
33LRRK20.96768412
34VRK20.87049470
35BRSK20.86891636
36ILK0.80557454
37RIPK40.80431846
38PRKAA20.77107145
39ICK0.72810910
40SGK2230.71853286
41SGK4940.71853286
42WNK10.70877467
43RAF10.68954865
44TAF10.61965930
45PRKAA10.57579086
46MTOR0.57048880
47CDK70.56907512
48PHKG20.56833170
49PHKG10.56833170
50PAK30.56258359
51STK380.55226589
52RPS6KB20.54645143
53CAMKK10.54097370
54CHUK0.53741146
55NEK20.53407663
56CCNB10.52214611
57DAPK30.48268339
58YES10.48011778
59EIF2AK10.45416975
60GRK10.41364482
61CDK30.40787012
62MAP2K60.40222182
63ERBB40.37483890
64AURKA0.35615667
65MAP3K110.34620945
66PAK20.33877009
67RPS6KA20.33602278
68DYRK1B0.32010550
69DYRK30.31336541
70PRKCZ0.29209747
71PTK60.28968053
72FLT30.28966730
73SGK30.27723169
74PAK40.26558871
75PDPK10.26427820
76SGK20.25768969
77RPS6KL10.25115580
78RPS6KC10.25115580
79OXSR10.23578638
80CAMK10.21955395
81EIF2AK30.21078493
82STK160.21044894
83EIF2AK20.20979654
84MAP3K20.19142611
85MAP3K30.16957544
86RPS6KA60.16614778
87PRKCH0.15420517
88MAPKAPK50.15143265
89MAPK130.14889125
90PTK20.14791828
91MAP3K70.14004456
92PDGFRA0.13981140
93DAPK10.13867871
94MST1R0.13523480
95HIPK20.13516499
96PDK10.12760028
97EPHB20.11776179
98TAOK30.09955474
99SGK10.09683108
100ACVR1B0.08550847

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.39582277
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.87018772
3Ribosome_Homo sapiens_hsa030103.05631454
4Arginine and proline metabolism_Homo sapiens_hsa003302.75055663
5Pyruvate metabolism_Homo sapiens_hsa006202.43605213
6Mineral absorption_Homo sapiens_hsa049782.32841950
7Renin-angiotensin system_Homo sapiens_hsa046142.19307855
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10924097
9Prostate cancer_Homo sapiens_hsa052152.00279705
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.97988852
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.97423854
12Phenylalanine metabolism_Homo sapiens_hsa003601.87604869
13mTOR signaling pathway_Homo sapiens_hsa041501.86132866
14Vitamin digestion and absorption_Homo sapiens_hsa049771.74363879
15Fatty acid metabolism_Homo sapiens_hsa012121.74357273
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56229046
17Fructose and mannose metabolism_Homo sapiens_hsa000511.55981096
18Histidine metabolism_Homo sapiens_hsa003401.53344068
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51252024
20AMPK signaling pathway_Homo sapiens_hsa041521.48453093
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47046273
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46856930
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44008155
24Sulfur metabolism_Homo sapiens_hsa009201.42466658
25Notch signaling pathway_Homo sapiens_hsa043301.42437115
26Peroxisome_Homo sapiens_hsa041461.32922068
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31527456
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25258027
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24954994
30Vibrio cholerae infection_Homo sapiens_hsa051101.19775563
31Propanoate metabolism_Homo sapiens_hsa006401.19760323
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17049228
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.15166113
34Lysine degradation_Homo sapiens_hsa003101.05347719
35Insulin signaling pathway_Homo sapiens_hsa049101.04974802
36Glucagon signaling pathway_Homo sapiens_hsa049221.04840862
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04479740
38Fatty acid degradation_Homo sapiens_hsa000711.04056860
39Bladder cancer_Homo sapiens_hsa052191.02745039
40Endometrial cancer_Homo sapiens_hsa052130.98986885
41VEGF signaling pathway_Homo sapiens_hsa043700.98968326
42Insulin resistance_Homo sapiens_hsa049310.92169329
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90330637
44Hepatitis C_Homo sapiens_hsa051600.89231764
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88752296
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83904029
47Nitrogen metabolism_Homo sapiens_hsa009100.81442610
48FoxO signaling pathway_Homo sapiens_hsa040680.80541460
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79140702
50Vitamin B6 metabolism_Homo sapiens_hsa007500.78802177
51Taste transduction_Homo sapiens_hsa047420.78718840
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76567987
53Choline metabolism in cancer_Homo sapiens_hsa052310.76367088
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.75283437
55Glutathione metabolism_Homo sapiens_hsa004800.73314194
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72968077
57ErbB signaling pathway_Homo sapiens_hsa040120.72749028
58HIF-1 signaling pathway_Homo sapiens_hsa040660.72307707
59Tryptophan metabolism_Homo sapiens_hsa003800.72215613
60Retinol metabolism_Homo sapiens_hsa008300.71705288
61Steroid biosynthesis_Homo sapiens_hsa001000.71693128
62Tyrosine metabolism_Homo sapiens_hsa003500.71161452
63Regulation of autophagy_Homo sapiens_hsa041400.67533115
64Biosynthesis of amino acids_Homo sapiens_hsa012300.65046435
65Tight junction_Homo sapiens_hsa045300.63186376
66Renin secretion_Homo sapiens_hsa049240.61946736
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.60490949
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57927268
69Carbon metabolism_Homo sapiens_hsa012000.56157133
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53610228
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53157834
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51164783
73Thyroid cancer_Homo sapiens_hsa052160.48550241
74Metabolic pathways_Homo sapiens_hsa011000.45399023
75Non-small cell lung cancer_Homo sapiens_hsa052230.44508095
76beta-Alanine metabolism_Homo sapiens_hsa004100.43801085
77Arginine biosynthesis_Homo sapiens_hsa002200.43698039
78Sphingolipid metabolism_Homo sapiens_hsa006000.43498569
79Synaptic vesicle cycle_Homo sapiens_hsa047210.43200215
80Salivary secretion_Homo sapiens_hsa049700.43076323
81PPAR signaling pathway_Homo sapiens_hsa033200.42740142
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42264044
83Protein export_Homo sapiens_hsa030600.42153295
84Dopaminergic synapse_Homo sapiens_hsa047280.41868759
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40614037
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40359162
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.39980513
88Circadian rhythm_Homo sapiens_hsa047100.37244631
89N-Glycan biosynthesis_Homo sapiens_hsa005100.35240086
90Pyrimidine metabolism_Homo sapiens_hsa002400.33746692
91Cocaine addiction_Homo sapiens_hsa050300.33001096
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32405566
93Starch and sucrose metabolism_Homo sapiens_hsa005000.32014298
94Sulfur relay system_Homo sapiens_hsa041220.31112525
95GnRH signaling pathway_Homo sapiens_hsa049120.30103567
96Thyroid hormone synthesis_Homo sapiens_hsa049180.27970415
97Oxidative phosphorylation_Homo sapiens_hsa001900.27857365
98Bile secretion_Homo sapiens_hsa049760.27016800
99Pancreatic cancer_Homo sapiens_hsa052120.26815851
100Chronic myeloid leukemia_Homo sapiens_hsa052200.26448862

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