PRADC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.19400977
2muscle filament sliding (GO:0030049)6.19400977
3DNA deamination (GO:0045006)6.04270455
4NADH metabolic process (GO:0006734)5.98246501
5DNA strand elongation involved in DNA replication (GO:0006271)5.18699609
6ribosomal small subunit assembly (GO:0000028)5.17459369
7telomere maintenance via semi-conservative replication (GO:0032201)5.01748213
8negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.95411845
9DNA strand elongation (GO:0022616)4.92434036
10DNA replication initiation (GO:0006270)4.76405944
11actin-mediated cell contraction (GO:0070252)4.75654806
12maturation of SSU-rRNA (GO:0030490)4.64716755
13skeletal muscle contraction (GO:0003009)4.59739575
14regulation of skeletal muscle contraction (GO:0014819)4.58502461
15creatine metabolic process (GO:0006600)4.55913842
16oxidative phosphorylation (GO:0006119)4.45052009
17telomere maintenance via recombination (GO:0000722)4.40498485
18respiratory electron transport chain (GO:0022904)4.35842450
19tricarboxylic acid cycle (GO:0006099)4.33798520
20viral transcription (GO:0019083)4.29026834
21DNA replication checkpoint (GO:0000076)4.25959018
22electron transport chain (GO:0022900)4.24919574
23proteasome assembly (GO:0043248)4.24095796
24sarcoplasmic reticulum calcium ion transport (GO:0070296)4.23189375
25ribosomal large subunit biogenesis (GO:0042273)4.20810371
26translational termination (GO:0006415)4.20526090
27formation of translation preinitiation complex (GO:0001731)4.17241921
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14285850
29nucleobase biosynthetic process (GO:0046112)4.04435638
30ribosomal small subunit biogenesis (GO:0042274)4.03078551
31positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.02748108
32translational elongation (GO:0006414)3.98858357
33mitotic recombination (GO:0006312)3.98772912
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.97745330
35mitotic metaphase plate congression (GO:0007080)3.97387446
36pseudouridine synthesis (GO:0001522)3.92591595
37CENP-A containing nucleosome assembly (GO:0034080)3.90568834
38rRNA modification (GO:0000154)3.90142971
39telomere maintenance via telomere lengthening (GO:0010833)3.88863055
40purine nucleobase biosynthetic process (GO:0009113)3.87440815
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85407890
42ATP synthesis coupled proton transport (GO:0015986)3.85066103
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85066103
44translational initiation (GO:0006413)3.84195036
45gluconeogenesis (GO:0006094)3.82145933
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.82038670
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.81113950
48regulation of relaxation of muscle (GO:1901077)3.77302541
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76663169
50chromatin remodeling at centromere (GO:0031055)3.76595191
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76122218
52cotranslational protein targeting to membrane (GO:0006613)3.67291587
53protein targeting to ER (GO:0045047)3.64848582
54oxaloacetate metabolic process (GO:0006107)3.61680430
55DNA unwinding involved in DNA replication (GO:0006268)3.61559048
56ribonucleoprotein complex biogenesis (GO:0022613)3.61545254
57sarcomere organization (GO:0045214)3.60980467
58striated muscle contraction (GO:0006941)3.59783201
59folic acid metabolic process (GO:0046655)3.59084512
60iron-sulfur cluster assembly (GO:0016226)3.56264910
61metallo-sulfur cluster assembly (GO:0031163)3.56264910
62protein maturation by protein folding (GO:0022417)3.55769873
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52016567
64rRNA processing (GO:0006364)3.51180438
65proline biosynthetic process (GO:0006561)3.51154110
66protein localization to endoplasmic reticulum (GO:0070972)3.49903022
67hexose biosynthetic process (GO:0019319)3.49357155
68transcription elongation from RNA polymerase III promoter (GO:0006385)3.48153184
69termination of RNA polymerase III transcription (GO:0006386)3.48153184
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47893369
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47830056
72monosaccharide biosynthetic process (GO:0046364)3.42643864
73DNA replication-independent nucleosome organization (GO:0034724)3.42132254
74DNA replication-independent nucleosome assembly (GO:0006336)3.42132254
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41388134
76metaphase plate congression (GO:0051310)3.39229521
77protein deneddylation (GO:0000338)3.38914348
78rRNA metabolic process (GO:0016072)3.38147614
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36841440
80ubiquinone biosynthetic process (GO:0006744)3.35817466
81spliceosomal snRNP assembly (GO:0000387)3.35681320
82heart process (GO:0003015)3.35196911
83heart contraction (GO:0060047)3.35196911
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34974592
85translation (GO:0006412)3.30145348
86ribosome biogenesis (GO:0042254)3.30060656
87cellular protein complex disassembly (GO:0043624)3.29769645
88transcription-coupled nucleotide-excision repair (GO:0006283)3.28894564
89ribosome assembly (GO:0042255)3.28821513
90glucan biosynthetic process (GO:0009250)3.28454835
91glycogen biosynthetic process (GO:0005978)3.28454835
92amino acid salvage (GO:0043102)3.27157763
93L-methionine salvage (GO:0071267)3.27157763
94L-methionine biosynthetic process (GO:0071265)3.27157763
95viral life cycle (GO:0019058)3.26643591
96galactose catabolic process (GO:0019388)3.26307663
97GDP-mannose metabolic process (GO:0019673)3.24496359
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23758569
99negative regulation of ligase activity (GO:0051352)3.23758569
100kinetochore assembly (GO:0051382)3.21502606
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19240547
102protein localization to kinetochore (GO:0034501)3.16886416
103G1/S transition of mitotic cell cycle (GO:0000082)3.14322255
104cell cycle G1/S phase transition (GO:0044843)3.14322255
105rRNA methylation (GO:0031167)3.14075670
106kinetochore organization (GO:0051383)3.13159459
107nucleoside diphosphate biosynthetic process (GO:0009133)3.12730892
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.12437279
109deoxyribonucleotide biosynthetic process (GO:0009263)3.11845786
110negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.11584178
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.11323719
112cardiac muscle contraction (GO:0060048)3.10143897
113mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07771890
114actin filament-based movement (GO:0030048)3.07722546
115mitotic nuclear envelope disassembly (GO:0007077)3.06538986
116protein localization to chromosome, centromeric region (GO:0071459)3.05476271
1172-deoxyribonucleotide biosynthetic process (GO:0009265)3.04860982
118deoxyribose phosphate biosynthetic process (GO:0046385)3.04860982
119histone exchange (GO:0043486)3.04573238
120folic acid-containing compound biosynthetic process (GO:0009396)3.03910758
121response to muscle activity (GO:0014850)3.02444769
122spliceosomal complex assembly (GO:0000245)3.02257780
123cellular component biogenesis (GO:0044085)3.01954857
124skeletal muscle fiber development (GO:0048741)3.01740006
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01418469
126regulation of double-strand break repair via homologous recombination (GO:0010569)3.01177324
127fructose metabolic process (GO:0006000)3.00588958
128quinone biosynthetic process (GO:1901663)3.00521804
129glycogen catabolic process (GO:0005980)2.99417017
130regulation of cellular amino acid metabolic process (GO:0006521)2.99196539
131IMP biosynthetic process (GO:0006188)2.98894947
1322-oxoglutarate metabolic process (GO:0006103)2.98091068
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97158449
134regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97050061
135nucleotide salvage (GO:0043173)2.96621070
136heme biosynthetic process (GO:0006783)2.96586741
137establishment of chromosome localization (GO:0051303)2.96542782
138attachment of spindle microtubules to kinetochore (GO:0008608)2.94061684
139IMP metabolic process (GO:0046040)2.92707723
140protein complex disassembly (GO:0043241)2.92002165
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91737834
142heme metabolic process (GO:0042168)2.91523753
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90994177
144L-phenylalanine metabolic process (GO:0006558)2.90994177
145protein targeting to mitochondrion (GO:0006626)2.90870230
146regulation of mitochondrial translation (GO:0070129)2.90588793
147response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.90455370
148mitotic chromosome condensation (GO:0007076)2.89846807
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89842488
150signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89842488
151signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89372569
152signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89372569
153signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89372569
1547-methylguanosine mRNA capping (GO:0006370)2.88872087
155pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87959473
156positive regulation of ligase activity (GO:0051351)2.87697648
157mitochondrial transport (GO:0006839)2.82888143
158ubiquinone metabolic process (GO:0006743)2.81943584
159lipopolysaccharide biosynthetic process (GO:0009103)2.81417064
160glycosphingolipid catabolic process (GO:0046479)2.80491792
161mitochondrial calcium ion homeostasis (GO:0051560)2.80464044
162tricarboxylic acid metabolic process (GO:0072350)2.79174980
163COPI coating of Golgi vesicle (GO:0048205)2.78858947
164Golgi transport vesicle coating (GO:0048200)2.78858947
165aerobic respiration (GO:0009060)2.78186326
166purine nucleotide salvage (GO:0032261)2.77342052
167establishment of protein localization to mitochondrial membrane (GO:0090151)2.77078358
168glucan catabolic process (GO:0009251)2.76193292
169negative regulation of cell size (GO:0045792)2.75995526
170protein retention in ER lumen (GO:0006621)2.75544933
171ATP biosynthetic process (GO:0006754)2.75371564
172pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74616839
173myotube cell development (GO:0014904)2.73473624
174establishment of protein localization to mitochondrion (GO:0072655)2.72355811
175nucleobase-containing small molecule interconversion (GO:0015949)2.70781208
176viral protein processing (GO:0019082)2.66097793
177mitochondrial fusion (GO:0008053)2.65127912
178myofibril assembly (GO:0030239)2.64702284
179regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64485688
180fatty acid beta-oxidation (GO:0006635)2.63299734
181base-excision repair, AP site formation (GO:0006285)2.63000516
182regulation of cellular respiration (GO:0043457)2.62438880
183protein complex biogenesis (GO:0070271)2.61479999
184hydrogen ion transmembrane transport (GO:1902600)2.60524467
185glycolipid catabolic process (GO:0019377)2.58882004
186succinate metabolic process (GO:0006105)2.57799697
187cellular carbohydrate biosynthetic process (GO:0034637)2.57246028
188muscle contraction (GO:0006936)2.57204376
189protein localization to mitochondrion (GO:0070585)2.56123045
190UV protection (GO:0009650)2.55316969
191negative regulation of necroptotic process (GO:0060546)2.55200713
192positive regulation of triglyceride lipase activity (GO:0061365)2.54208091
193positive regulation of lipoprotein lipase activity (GO:0051006)2.54208091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.21263318
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23342263
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21303662
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.78407687
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45065857
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39034111
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.20691780
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.08218848
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.08161781
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06140127
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95990338
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.95750476
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91656739
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81024309
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75334718
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73171564
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62084442
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45103728
19VDR_23849224_ChIP-Seq_CD4+_Human2.44017569
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43814648
21XRN2_22483619_ChIP-Seq_HELA_Human2.32088015
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22220212
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17552304
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16437307
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.16008058
26DCP1A_22483619_ChIP-Seq_HELA_Human2.15821001
27GABP_19822575_ChIP-Seq_HepG2_Human2.12822044
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12150854
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11869303
30LXR_22292898_ChIP-Seq_THP-1_Human2.08342357
31FOXP3_21729870_ChIP-Seq_TREG_Human2.06049506
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05948156
33TET1_21451524_ChIP-Seq_MESCs_Mouse2.04338056
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03987319
35RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03705655
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01624573
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01621105
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01427351
39AR_21909140_ChIP-Seq_LNCAP_Human1.91233979
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.90591843
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86903384
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78530268
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.78143917
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77001401
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.76370140
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75569911
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75078687
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75038309
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74517990
50TTF2_22483619_ChIP-Seq_HELA_Human1.73224834
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.71921708
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67593932
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67036162
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65833960
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63671379
56P68_20966046_ChIP-Seq_HELA_Human1.60497540
57CIITA_25753668_ChIP-Seq_RAJI_Human1.59086967
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58878985
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58658667
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58639594
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57247321
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55814041
63BCL6_27268052_Chip-Seq_Bcells_Human1.54365930
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52282710
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48551866
66MYC_22102868_ChIP-Seq_BL_Human1.47849229
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47602988
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.47506779
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46044676
70RACK7_27058665_Chip-Seq_MCF-7_Human1.43214708
71BCOR_27268052_Chip-Seq_Bcells_Human1.42215699
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.42052398
73SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.40711251
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39682722
75KDM5A_27292631_Chip-Seq_BREAST_Human1.38026621
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37163429
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.34987775
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.31566697
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.29197599
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28990392
81ELK1_19687146_ChIP-ChIP_HELA_Human1.28570961
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27833309
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27632247
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27616177
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26704075
86CTCF_21964334_Chip-Seq_Bcells_Human1.26067512
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26002764
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25391831
89SA1_27219007_Chip-Seq_Bcells_Human1.25210667
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23086838
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23008200
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19857883
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18290068
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18020543
95VDR_21846776_ChIP-Seq_THP-1_Human1.16148872
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.14544987
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12717272
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12514993
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08303249
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08182733
101PHF8_20622854_ChIP-Seq_HELA_Human1.07840557
102E2F1_20622854_ChIP-Seq_HELA_Human1.07089971
103SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05948082
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05934666
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05515919
106SMC4_20622854_ChIP-Seq_HELA_Human1.05436239
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.05271702
108MYC_18940864_ChIP-ChIP_HL60_Human1.04948125
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04919351
110TFEB_21752829_ChIP-Seq_HELA_Human1.04825146
111CTCF_27219007_Chip-Seq_Bcells_Human1.03978530
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.03751006
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03127736
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.00759746
115RARB_24833708_ChIP-Seq_LIVER_Mouse1.00639229
116SPI1_23547873_ChIP-Seq_NB4_Human1.00588876
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00010743
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99991326
119ZNF263_19887448_ChIP-Seq_K562_Human0.99331955
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98698727
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97800566
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97788053
123CTCF_20526341_ChIP-Seq_ESCs_Human0.97685242
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97034869
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96106516
126CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95583555
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95556290
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92877692
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92567546
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90286242
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90075356
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89693720
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89466313
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89262772
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85492238
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84299627
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83703516
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82153951
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81918505
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81844100
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80339316
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78981798
143TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78972549
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78330800
145FOXP1_21924763_ChIP-Seq_HESCs_Human0.78081000
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78059844
147CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76661000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.12415179
2MP0000751_myopathy4.78995655
3MP0010094_abnormal_chromosome_stability4.70412740
4MP0003111_abnormal_nucleus_morphology4.69322312
5MP0004957_abnormal_blastocyst_morpholog4.66380074
6MP0000749_muscle_degeneration4.18892862
7MP0003077_abnormal_cell_cycle3.93635467
8MP0004145_abnormal_muscle_electrophysio3.83176091
9MP0003806_abnormal_nucleotide_metabolis3.11527103
10MP0002396_abnormal_hematopoietic_system3.05943596
11MP0005058_abnormal_lysosome_morphology3.05655448
12MP0008058_abnormal_DNA_repair2.94825930
13MP0004036_abnormal_muscle_relaxation2.88149506
14MP0008057_abnormal_DNA_replication2.85807037
15MP0000747_muscle_weakness2.84904959
16MP0000759_abnormal_skeletal_muscle2.62522649
17MP0004233_abnormal_muscle_weight2.61432378
18MP0003718_maternal_effect2.55880407
19MP0005670_abnormal_white_adipose2.51946895
20MP0004087_abnormal_muscle_fiber2.39923923
21MP0008007_abnormal_cellular_replicative2.37482414
22MP0008932_abnormal_embryonic_tissue2.36620574
23MP0002837_dystrophic_cardiac_calcinosis2.33198294
24MP0002106_abnormal_muscle_physiology2.31855711
25MP0004130_abnormal_muscle_cell2.23677264
26MP0000490_abnormal_crypts_of2.10561145
27MP0002269_muscular_atrophy2.10023404
28MP0001730_embryonic_growth_arrest2.06732223
29MP0002332_abnormal_exercise_endurance2.06437174
30MP0003646_muscle_fatigue2.05528167
31MP0003763_abnormal_thymus_physiology2.05172969
32MP0002139_abnormal_hepatobiliary_system2.04395918
33MP0002132_abnormal_respiratory_system2.02125407
34MP0006036_abnormal_mitochondrial_physio1.98486852
35MP0003786_premature_aging1.93649990
36MP0005369_muscle_phenotype1.86456922
37MP0003656_abnormal_erythrocyte_physiolo1.85229663
38MP0003191_abnormal_cellular_cholesterol1.83342779
39MP0000350_abnormal_cell_proliferation1.76423140
40MP0003186_abnormal_redox_activity1.75266986
41MP0002972_abnormal_cardiac_muscle1.74507183
42MP0005620_abnormal_muscle_contractility1.73723143
43MP0009333_abnormal_splenocyte_physiolog1.73693202
44MP0004084_abnormal_cardiac_muscle1.72315441
45MP0005083_abnormal_biliary_tract1.69094878
46MP0001545_abnormal_hematopoietic_system1.68116833
47MP0005397_hematopoietic_system_phenotyp1.68116833
48MP0005360_urolithiasis1.63655011
49MP0002019_abnormal_tumor_incidence1.57297646
50MP0005365_abnormal_bile_salt1.56944319
51MP0004147_increased_porphyrin_level1.52670217
52MP0000465_gastrointestinal_hemorrhage1.51100862
53MP0000343_altered_response_to1.45562814
54MP0003123_paternal_imprinting1.43021869
55MP0000313_abnormal_cell_death1.42521719
56MP0001697_abnormal_embryo_size1.38990084
57MP0010352_gastrointestinal_tract_polyps1.38306348
58MP0002080_prenatal_lethality1.37925898
59MP0004510_myositis1.36880419
60MP0004215_abnormal_myocardial_fiber1.35869891
61MP0006292_abnormal_olfactory_placode1.35044478
62MP0002971_abnormal_brown_adipose1.33882989
63MP0002398_abnormal_bone_marrow1.33381571
64MP0005666_abnormal_adipose_tissue1.33232107
65MP0000733_abnormal_muscle_development1.32921908
66MP0006035_abnormal_mitochondrial_morpho1.31534132
67MP0008877_abnormal_DNA_methylation1.30655864
68MP0005165_increased_susceptibility_to1.30604282
69MP0003879_abnormal_hair_cell1.28647479
70MP0002163_abnormal_gland_morphology1.27407549
71MP0002722_abnormal_immune_system1.25937542
72MP0003137_abnormal_impulse_conducting1.25881818
73MP0000689_abnormal_spleen_morphology1.25538231
74MP0005584_abnormal_enzyme/coenzyme_acti1.22748080
75MP0005332_abnormal_amino_acid1.22314570
76MP0003950_abnormal_plasma_membrane1.21859425
77MP0004808_abnormal_hematopoietic_stem1.19526552
78MP0000703_abnormal_thymus_morphology1.18674552
79MP0009379_abnormal_foot_pigmentation1.18564761
80MP0001672_abnormal_embryogenesis/_devel1.16988193
81MP0005380_embryogenesis_phenotype1.16988193
82MP0005075_abnormal_melanosome_morpholog1.16781160
83MP0001529_abnormal_vocalization1.15901995
84MP0009840_abnormal_foam_cell1.15710030
85MP0005385_cardiovascular_system_phenoty1.13277718
86MP0001544_abnormal_cardiovascular_syste1.13277718
87MP0000358_abnormal_cell_content/1.12511153
88MP0004185_abnormal_adipocyte_glucose1.12126863
89MP0002210_abnormal_sex_determination1.11574214
90MP0001661_extended_life_span1.10566227
91MP0001929_abnormal_gametogenesis1.10119343
92MP0005375_adipose_tissue_phenotype1.09342535
93MP0003075_altered_response_to1.09041297
94MP0002429_abnormal_blood_cell1.07762786
95MP0006138_congestive_heart_failure1.07609883
96MP0001764_abnormal_homeostasis1.04474953
97MP0000003_abnormal_adipose_tissue1.03821298
98MP0001145_abnormal_male_reproductive1.02579134
99MP0003984_embryonic_growth_retardation1.02497057
100MP0001853_heart_inflammation1.00198771
101MP0002088_abnormal_embryonic_growth/wei0.97243291
102MP0000653_abnormal_sex_gland0.95844736
103MP0010630_abnormal_cardiac_muscle0.95424598
104MP0002127_abnormal_cardiovascular_syste0.93547771
105MP0000013_abnormal_adipose_tissue0.92764690
106MP0003221_abnormal_cardiomyocyte_apopto0.92620688
107MP0000716_abnormal_immune_system0.92461447
108MP0001873_stomach_inflammation0.91790570
109MP0002085_abnormal_embryonic_tissue0.91697559
110MP0010030_abnormal_orbit_morphology0.91544508
111MP0003011_delayed_dark_adaptation0.91541689
112MP0006054_spinal_hemorrhage0.89272882
113MP0002086_abnormal_extraembryonic_tissu0.86490688
114MP0005220_abnormal_exocrine_pancreas0.86110414
115MP0000685_abnormal_immune_system0.84501825
116MP0005451_abnormal_body_composition0.82418567
117MP0003705_abnormal_hypodermis_morpholog0.81073066
118MP0005266_abnormal_metabolism0.79969718
119MP0000372_irregular_coat_pigmentation0.79957912
120MP0005671_abnormal_response_to0.79423518
121MP0002118_abnormal_lipid_homeostasis0.79227414
122MP0001119_abnormal_female_reproductive0.78475482
123MP0005636_abnormal_mineral_homeostasis0.77821870
124MP0005408_hypopigmentation0.77412583
125MP0001919_abnormal_reproductive_system0.76016618
126MP0002108_abnormal_muscle_morphology0.75517383
127MP0002405_respiratory_system_inflammati0.74733428
128MP0003567_abnormal_fetal_cardiomyocyte0.74524791
129MP0001727_abnormal_embryo_implantation0.73068499
130MP0000858_altered_metastatic_potential0.72868658
131MP0003959_abnormal_lean_body0.72310972
132MP0008789_abnormal_olfactory_epithelium0.72291612
133MP0008775_abnormal_heart_ventricle0.72191515
134MP0009697_abnormal_copulation0.72089554
135MP0009643_abnormal_urine_homeostasis0.70388239
136MP0002420_abnormal_adaptive_immunity0.69669462
137MP0005389_reproductive_system_phenotype0.69090986
138MP0003315_abnormal_perineum_morphology0.68885537
139MP0004858_abnormal_nervous_system0.68795411
140MP0005166_decreased_susceptibility_to0.68595309
141MP0002084_abnormal_developmental_patter0.67700036
142MP0002078_abnormal_glucose_homeostasis0.67564921
143MP0003699_abnormal_female_reproductive0.67293899
144MP0003866_abnormal_defecation0.66842693
145MP0002095_abnormal_skin_pigmentation0.66444674
146MP0001819_abnormal_immune_cell0.65685409
147MP0000750_abnormal_muscle_regeneration0.65020592
148MP0005395_other_phenotype0.64937609
149MP0001800_abnormal_humoral_immune0.64873541
150MP0001542_abnormal_bone_strength0.64723039
151MP0005384_cellular_phenotype0.64495180
152MP0003329_amyloid_beta_deposits0.64367650
153MP0010307_abnormal_tumor_latency0.64363344
154MP0008874_decreased_physiological_sensi0.63094855
155MP0000678_abnormal_parathyroid_gland0.62918246
156MP0005464_abnormal_platelet_physiology0.62531293
157MP0005535_abnormal_body_temperature0.60797202
158MP0009672_abnormal_birth_weight0.60548029
159MP0002653_abnormal_ependyma_morphology0.60390839
160MP0002970_abnormal_white_adipose0.59925108
161MP0000609_abnormal_liver_physiology0.59667210
162MP0010329_abnormal_lipoprotein_level0.59629108
163MP0002102_abnormal_ear_morphology0.59381507
164MP0002822_catalepsy0.58909593
165MP0005621_abnormal_cell_physiology0.58818739
166MP0005330_cardiomyopathy0.58689754
167MP0005334_abnormal_fat_pad0.57224076
168MP0000613_abnormal_salivary_gland0.56441086
169MP0005501_abnormal_skin_physiology0.56263435
170MP0005452_abnormal_adipose_tissue0.55787629
171MP0004484_altered_response_of0.55548424
172MP0005319_abnormal_enzyme/_coenzyme0.55520202
173MP0000477_abnormal_intestine_morphology0.55439562
174MP0000604_amyloidosis0.54363749
175MP0009384_cardiac_valve_regurgitation0.50919439
176MP0008260_abnormal_autophagy0.50748663
177MP0008438_abnormal_cutaneous_collagen0.50446184
178MP0002638_abnormal_pupillary_reflex0.50129241
179MP0001243_abnormal_dermal_layer0.50071408
180MP0005376_homeostasis/metabolism_phenot0.49332955
181MP0001905_abnormal_dopamine_level0.44689486

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.99095372
2Muscle fiber inclusion bodies (HP:0100299)6.89337809
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.75490479
4Abnormal number of erythroid precursors (HP:0012131)5.97479039
5Abnormality of cells of the erythroid lineage (HP:0012130)5.83526259
6Exercise-induced myalgia (HP:0003738)5.39119475
7Type 1 muscle fiber predominance (HP:0003803)5.09294728
8Birth length less than 3rd percentile (HP:0003561)5.09227954
9Rhabdomyolysis (HP:0003201)4.71191566
10Myopathic facies (HP:0002058)4.68209766
11Myoglobinuria (HP:0002913)4.35042776
12Oral leukoplakia (HP:0002745)4.33265307
13Exercise-induced muscle cramps (HP:0003710)4.31786967
14Aplastic anemia (HP:0001915)4.16138081
15Distal lower limb muscle weakness (HP:0009053)4.07809968
16Reticulocytopenia (HP:0001896)4.07424270
17Centrally nucleated skeletal muscle fibers (HP:0003687)4.03709735
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.96078102
19Abnormality of alanine metabolism (HP:0010916)3.96078102
20Hyperalaninemia (HP:0003348)3.96078102
21Microretrognathia (HP:0000308)3.95996163
22Breast hypoplasia (HP:0003187)3.88799251
23EMG: myopathic abnormalities (HP:0003458)3.85944495
24Cerebral hypomyelination (HP:0006808)3.71454773
25Ragged-red muscle fibers (HP:0003200)3.69242525
26Macrocytic anemia (HP:0001972)3.65867572
27Neck muscle weakness (HP:0000467)3.51974937
28Rough bone trabeculation (HP:0100670)3.43338645
29Carpal bone hypoplasia (HP:0001498)3.32443496
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32208702
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32208702
32Abnormality of the heme biosynthetic pathway (HP:0010472)3.24428052
33Pallor (HP:0000980)3.23983018
34Abnormality of skeletal muscle fiber size (HP:0012084)3.19523135
35Hepatocellular necrosis (HP:0001404)3.16546174
36Increased serum lactate (HP:0002151)3.15861011
37Muscle stiffness (HP:0003552)3.14291575
38Hepatic necrosis (HP:0002605)3.12585699
39Muscle fiber splitting (HP:0003555)3.11563648
40Hyporeflexia of lower limbs (HP:0002600)3.11346685
41Distal arthrogryposis (HP:0005684)3.11033876
42Muscle hypertrophy of the lower extremities (HP:0008968)3.05658272
43Bulbar palsy (HP:0001283)3.01959499
44Asymmetric septal hypertrophy (HP:0001670)2.92989549
45Increased CSF lactate (HP:0002490)2.86325723
46Increased connective tissue (HP:0009025)2.84042797
473-Methylglutaconic aciduria (HP:0003535)2.82481070
48Abnormality of the calf musculature (HP:0001430)2.81222219
49Mitochondrial inheritance (HP:0001427)2.80731782
50Increased hepatocellular lipid droplets (HP:0006565)2.79273295
51Lipid accumulation in hepatocytes (HP:0006561)2.78988183
52Sudden death (HP:0001699)2.77931317
53Round ear (HP:0100830)2.77645508
54Ulnar deviation of the wrist (HP:0003049)2.74843592
55Secondary amenorrhea (HP:0000869)2.74493845
56Colon cancer (HP:0003003)2.72965246
57Multiple enchondromatosis (HP:0005701)2.72619377
58Premature ovarian failure (HP:0008209)2.66899583
59Premature graying of hair (HP:0002216)2.64623256
60Calf muscle hypertrophy (HP:0008981)2.64449411
61Abnormality of glycolipid metabolism (HP:0010969)2.63589735
62Abnormality of liposaccharide metabolism (HP:0010968)2.63589735
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.63589735
64Abnormal mitochondria in muscle tissue (HP:0008316)2.63574360
65Acute necrotizing encephalopathy (HP:0006965)2.63447084
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57954916
67Pancytopenia (HP:0001876)2.57891275
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.57671177
69Patellar aplasia (HP:0006443)2.56799174
70Increased variability in muscle fiber diameter (HP:0003557)2.56190742
71Aplasia/Hypoplasia of the patella (HP:0006498)2.51058526
72Abnormality of fatty-acid metabolism (HP:0004359)2.50823867
73Progressive muscle weakness (HP:0003323)2.48935016
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.48453221
75Lactic acidosis (HP:0003128)2.46052971
76Abnormality of the anterior horn cell (HP:0006802)2.46038983
77Degeneration of anterior horn cells (HP:0002398)2.46038983
78Acute encephalopathy (HP:0006846)2.45407497
79Respiratory difficulties (HP:0002880)2.44875378
80Rimmed vacuoles (HP:0003805)2.43620345
81Distal lower limb amyotrophy (HP:0008944)2.42296197
82Generalized aminoaciduria (HP:0002909)2.40631443
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40050713
84Abnormal trabecular bone morphology (HP:0100671)2.38556532
85Increased intramyocellular lipid droplets (HP:0012240)2.37903244
86Exertional dyspnea (HP:0002875)2.34134606
87Increased muscle lipid content (HP:0009058)2.33133193
88Abnormal spermatogenesis (HP:0008669)2.32953161
89Unsteady gait (HP:0002317)2.32626112
90Bundle branch block (HP:0011710)2.32332264
91Myotonia (HP:0002486)2.30985644
92Mildly elevated creatine phosphokinase (HP:0008180)2.29653831
93Abnormality of chromosome stability (HP:0003220)2.28871164
94CNS hypomyelination (HP:0003429)2.25334968
95Cerebral palsy (HP:0100021)2.24847739
96Emotional lability (HP:0000712)2.23529039
97Sparse eyelashes (HP:0000653)2.22704987
98Renal Fanconi syndrome (HP:0001994)2.21986177
99Bone marrow hypocellularity (HP:0005528)2.21645808
100Abnormality of the preputium (HP:0100587)2.21511485
101Lipoatrophy (HP:0100578)2.21430295
102Dilated cardiomyopathy (HP:0001644)2.19928174
103CNS demyelination (HP:0007305)2.19780768
104Cellular immunodeficiency (HP:0005374)2.19734794
105Increased serum pyruvate (HP:0003542)2.19635046
106Abnormality of glycolysis (HP:0004366)2.19635046
107Megaloblastic anemia (HP:0001889)2.19625588
108Cerebral edema (HP:0002181)2.17286750
109Microvesicular hepatic steatosis (HP:0001414)2.16691067
110Vertebral compression fractures (HP:0002953)2.16566161
111Chromsome breakage (HP:0040012)2.15758861
112Death in infancy (HP:0001522)2.15448020
113Trismus (HP:0000211)2.15197200
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13044170
115Progressive macrocephaly (HP:0004481)2.12432837
116Irregular epiphyses (HP:0010582)2.11580638
117Generalized muscle weakness (HP:0003324)2.10085805
118Muscle fiber atrophy (HP:0100295)2.09755952
119Areflexia of lower limbs (HP:0002522)2.07767972
120IgM deficiency (HP:0002850)2.06476538
121Selective tooth agenesis (HP:0001592)2.04899173
122Thrombocytosis (HP:0001894)2.02991862
123Cholelithiasis (HP:0001081)2.02738182
124Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01290508
125Abnormal gallbladder physiology (HP:0012438)2.01146986
126Cholecystitis (HP:0001082)2.01146986
127Absent epiphyses (HP:0010577)2.00860282
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.00860282
129Lymphoma (HP:0002665)2.00010037
130Absent thumb (HP:0009777)1.99670022
131Abnormality of reticulocytes (HP:0004312)1.97657970
132Calcaneovalgus deformity (HP:0001848)1.96489219
133Respiratory failure (HP:0002878)1.95974705
134Ventricular tachycardia (HP:0004756)1.95362231
135Postnatal microcephaly (HP:0005484)1.94984592
136Personality changes (HP:0000751)1.92939227
137Agnosia (HP:0010524)1.92766792
138Pulmonary fibrosis (HP:0002206)1.92423968
139Achilles tendon contracture (HP:0001771)1.92195973
140Myelodysplasia (HP:0002863)1.91578086
141Type 2 muscle fiber atrophy (HP:0003554)1.91535973
142Abnormality of serum amino acid levels (HP:0003112)1.91444267
143Subaortic stenosis (HP:0001682)1.90929174
144Abnormality of the left ventricular outflow tract (HP:0011103)1.90929174
145Meckel diverticulum (HP:0002245)1.90528498
146Type I transferrin isoform profile (HP:0003642)1.90009852
147Aplasia/hypoplasia of the uterus (HP:0008684)1.89805544
148Nausea (HP:0002018)1.89178575
149Spinal rigidity (HP:0003306)1.89060588
150Respiratory insufficiency due to muscle weakness (HP:0002747)1.88829113
151Frequent falls (HP:0002359)1.88317157
152Exercise intolerance (HP:0003546)1.87324157
153Hyperammonemia (HP:0001987)1.87162510
154Malignant hyperthermia (HP:0002047)1.86767094
155Hypoplasia of the uterus (HP:0000013)1.85430894
156Dicarboxylic aciduria (HP:0003215)1.84397105
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84397105
158Neoplasm of the pancreas (HP:0002894)1.84365936
159Difficulty climbing stairs (HP:0003551)1.84253400
160Reduced antithrombin III activity (HP:0001976)1.84236367
161Rhabdomyosarcoma (HP:0002859)1.84108145
162Neoplasm of head and neck (HP:0012288)1.83998920
163Esophageal neoplasm (HP:0100751)1.83998920
164Microcytic anemia (HP:0001935)1.83475862
165Abnormality of the umbilical cord (HP:0010881)1.82184391
166Abnormal atrioventricular conduction (HP:0005150)1.81429194
167Fetal akinesia sequence (HP:0001989)1.80481486
168Abnormal gallbladder morphology (HP:0012437)1.77532119
169Foot dorsiflexor weakness (HP:0009027)1.76745741
170Abnormality of the Achilles tendon (HP:0005109)1.76160668
171Weak cry (HP:0001612)1.75676468
172Limb-girdle muscle atrophy (HP:0003797)1.74489934
173Axonal loss (HP:0003447)1.73302670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.98490569
2OBSCN4.92612123
3WEE14.21295791
4NME23.67478636
5TTN3.54267646
6EIF2AK13.34519280
7CDC73.20229785
8PHKG13.01442683
9PHKG23.01442683
10LIMK12.93582612
11STK162.70062325
12ACVR1B2.64760115
13NEK22.62245712
14PLK42.54588315
15TESK22.34737205
16DYRK32.15060812
17EIF2AK32.14606703
18ERN12.11473451
19VRK12.04820846
20CCNB11.96240168
21BRSK21.93619054
22VRK21.93216554
23TTK1.89279480
24NME11.83060558
25BCKDK1.81256205
26TLK11.79598205
27PDK21.73339000
28SCYL21.72397328
29PLK11.71359507
30IRAK31.68818933
31SRPK11.64538412
32NEK11.58898026
33AURKB1.55729893
34TSSK61.53490369
35BRSK11.49494453
36MAP4K11.48282446
37AURKA1.42038139
38CDK71.39542361
39MYLK1.36898610
40TBK11.32104267
41MAP3K81.29801357
42PASK1.29582575
43CDK81.27455887
44KDR1.27022090
45TAOK21.23928693
46PIM21.19831365
47STK101.16735851
48ATR1.15418338
49CHEK21.15094982
50CDK41.15009401
51CDK191.10172870
52BRAF1.08793322
53RAF11.05473933
54ARAF1.05423606
55MAP3K111.05406835
56LMTK21.05243634
57CAMK2G1.04807032
58MAPK121.01459314
59RPS6KB21.00772251
60PIK3CG0.99536255
61TAOK30.93301638
62TRIB30.87842606
63ICK0.83299812
64LRRK20.81882788
65MAP2K20.80913385
66DYRK20.79705651
67PLK30.79594399
68RPS6KA40.78865690
69PRKD30.74106124
70CHEK10.73721159
71ZAP700.73677624
72MAPKAPK30.69478134
73EPHB20.69022328
74AKT20.68866184
75ABL20.68203366
76PBK0.68030682
77TEC0.66826655
78PAK10.64928283
79EEF2K0.64356052
80MAP3K120.64151159
81MAP3K10.63722240
82GRK60.63525498
83CSNK2A10.63327050
84DAPK30.62868764
85PDPK10.62837613
86CAMK2D0.62385670
87ILK0.62104668
88ZAK0.61991835
89PRPF4B0.61698882
90MKNK20.59568760
91MKNK10.58829869
92MAPK40.57427363
93PIM10.57065987
94CSNK2A20.56055421
95MST40.55271786
96EPHB10.54495070
97MAP3K30.54140024
98BTK0.53511585
99CSNK1G30.52687685
100PRKCI0.51724544
101KSR20.50185216
102DAPK10.49659153
103PRKD10.49020546
104CDK20.48626256
105FLT30.46819410
106SMG10.45731348
107SIK10.45559876
108MAP2K30.45368556
109EPHA20.44648828
110RIPK10.42381921
111PKN20.41882447
112PDK30.40704323
113PDK40.40704323
114TGFBR10.40647813
115MAP3K50.40597524
116ATM0.39702575
117MAP3K100.39105708
118EIF2AK20.39075361
119TESK10.38770558
120MAPKAPK50.38251755
121CAMK2B0.37407540
122MOS0.36976486
123SYK0.36463485
124CDK140.36411921
125NLK0.35557255
126MUSK0.34624531
127PRKG20.32950442
128MAP3K130.32824959
129BLK0.32604090
130TYK20.32461844
131IKBKB0.31846135
132STK40.31272785
133MAP2K10.31084991
134MELK0.30759571
135CSNK1G20.30620731
136MAPK110.30219401
137KIT0.30089280
138CDK10.29932824
139MAP3K60.29539058
140PAK40.29193884
141RPS6KA20.28991833
142ROCK10.28403860
143MAP2K70.28375041
144PINK10.27788002
145CDK11A0.27638725
146MST1R0.27169947
147STK38L0.26525033
148PKN10.26283604
149CDK150.25892315
150RPS6KA50.25652487
151CSNK1A1L0.25592569
152GRK70.22966554
153PDK10.22928477
154PRKAA20.22323282
155CDK180.21552069

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24970805
2Mismatch repair_Homo sapiens_hsa034304.08212833
3Ribosome_Homo sapiens_hsa030104.01908499
4Proteasome_Homo sapiens_hsa030503.70080446
5RNA polymerase_Homo sapiens_hsa030203.55042954
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.48494195
7Fatty acid elongation_Homo sapiens_hsa000623.21175069
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18765845
9Homologous recombination_Homo sapiens_hsa034403.11376468
10Base excision repair_Homo sapiens_hsa034103.05336628
11Pyrimidine metabolism_Homo sapiens_hsa002402.86579529
12Nucleotide excision repair_Homo sapiens_hsa034202.73743529
13Spliceosome_Homo sapiens_hsa030402.72981359
14RNA transport_Homo sapiens_hsa030132.48664818
15Cell cycle_Homo sapiens_hsa041102.40126142
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03723469
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96756345
18One carbon pool by folate_Homo sapiens_hsa006701.96128418
19Vitamin B6 metabolism_Homo sapiens_hsa007501.94292757
20Phenylalanine metabolism_Homo sapiens_hsa003601.89104353
21Folate biosynthesis_Homo sapiens_hsa007901.84740778
22Sulfur metabolism_Homo sapiens_hsa009201.82203375
23Fanconi anemia pathway_Homo sapiens_hsa034601.69628837
24Basal transcription factors_Homo sapiens_hsa030221.64436803
25RNA degradation_Homo sapiens_hsa030181.62331463
26Purine metabolism_Homo sapiens_hsa002301.58956383
27Non-homologous end-joining_Homo sapiens_hsa034501.58891983
28Parkinsons disease_Homo sapiens_hsa050121.56931045
29Fatty acid metabolism_Homo sapiens_hsa012121.56280236
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55751107
31Sulfur relay system_Homo sapiens_hsa041221.51941987
32Pentose phosphate pathway_Homo sapiens_hsa000301.51797312
33Oxidative phosphorylation_Homo sapiens_hsa001901.45663021
34Protein export_Homo sapiens_hsa030601.40581380
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.37139440
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.34666555
37Huntingtons disease_Homo sapiens_hsa050161.29220100
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28801909
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.28343149
40Arginine biosynthesis_Homo sapiens_hsa002201.27521841
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.26071701
42Dilated cardiomyopathy_Homo sapiens_hsa054141.21163802
43p53 signaling pathway_Homo sapiens_hsa041151.19885702
44PPAR signaling pathway_Homo sapiens_hsa033201.14381009
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13242238
46Biosynthesis of amino acids_Homo sapiens_hsa012301.07929262
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07735547
48Tyrosine metabolism_Homo sapiens_hsa003501.06274614
49Vibrio cholerae infection_Homo sapiens_hsa051100.99339507
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96245121
51Carbon metabolism_Homo sapiens_hsa012000.95494914
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91279045
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.90394353
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86437953
55Selenocompound metabolism_Homo sapiens_hsa004500.85740075
56mRNA surveillance pathway_Homo sapiens_hsa030150.85228785
57Lysosome_Homo sapiens_hsa041420.84123792
58Epstein-Barr virus infection_Homo sapiens_hsa051690.82083121
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81917075
60Glutathione metabolism_Homo sapiens_hsa004800.81207336
61Alzheimers disease_Homo sapiens_hsa050100.80488434
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75979744
63Oocyte meiosis_Homo sapiens_hsa041140.75551661
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70308642
65Systemic lupus erythematosus_Homo sapiens_hsa053220.65327951
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64511330
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64102953
68Collecting duct acid secretion_Homo sapiens_hsa049660.62865641
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61760128
70Metabolic pathways_Homo sapiens_hsa011000.61462856
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61210419
72Starch and sucrose metabolism_Homo sapiens_hsa005000.60225145
73Antigen processing and presentation_Homo sapiens_hsa046120.59587860
74Butanoate metabolism_Homo sapiens_hsa006500.58690112
75N-Glycan biosynthesis_Homo sapiens_hsa005100.58660329
76Insulin signaling pathway_Homo sapiens_hsa049100.57587567
77Regulation of autophagy_Homo sapiens_hsa041400.57303244
78Steroid biosynthesis_Homo sapiens_hsa001000.56735004
79Primary immunodeficiency_Homo sapiens_hsa053400.56119704
80Prion diseases_Homo sapiens_hsa050200.54553673
81Synaptic vesicle cycle_Homo sapiens_hsa047210.52464653
82Fat digestion and absorption_Homo sapiens_hsa049750.49006085
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48855391
84Caffeine metabolism_Homo sapiens_hsa002320.48636484
85Herpes simplex infection_Homo sapiens_hsa051680.48584257
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48384439
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47850186
88Thyroid cancer_Homo sapiens_hsa052160.47210519
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44773978
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43548753
91Pyruvate metabolism_Homo sapiens_hsa006200.42251963
92AMPK signaling pathway_Homo sapiens_hsa041520.41859620
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40314249
94Tryptophan metabolism_Homo sapiens_hsa003800.40207921
95Viral carcinogenesis_Homo sapiens_hsa052030.40024802
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.38808988
97Galactose metabolism_Homo sapiens_hsa000520.37492733
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37045670
99HTLV-I infection_Homo sapiens_hsa051660.36004769
100Glucagon signaling pathway_Homo sapiens_hsa049220.35805423
101Fructose and mannose metabolism_Homo sapiens_hsa000510.31420142
102Salmonella infection_Homo sapiens_hsa051320.29117643
103Propanoate metabolism_Homo sapiens_hsa006400.29016174
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28523935
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27920919
106Sphingolipid metabolism_Homo sapiens_hsa006000.26012466
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.24916455
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24512281
109Arginine and proline metabolism_Homo sapiens_hsa003300.24457869
110Peroxisome_Homo sapiens_hsa041460.23677874
111Cardiac muscle contraction_Homo sapiens_hsa042600.22180144
112Insulin resistance_Homo sapiens_hsa049310.21800324
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21448355
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.20205048
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20176709
116Chemical carcinogenesis_Homo sapiens_hsa052040.19426410
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19420477
118Renin-angiotensin system_Homo sapiens_hsa046140.18815813
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17875186
120Other glycan degradation_Homo sapiens_hsa005110.17648202
121beta-Alanine metabolism_Homo sapiens_hsa004100.17468802
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17462165
123Fatty acid biosynthesis_Homo sapiens_hsa000610.15942860
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13836064
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13472803
126Shigellosis_Homo sapiens_hsa051310.13447658
127Apoptosis_Homo sapiens_hsa042100.11735267
128Bladder cancer_Homo sapiens_hsa052190.10942022
129Arachidonic acid metabolism_Homo sapiens_hsa005900.10116452
130Legionellosis_Homo sapiens_hsa051340.09816295
131Hematopoietic cell lineage_Homo sapiens_hsa046400.08933558
132Alcoholism_Homo sapiens_hsa050340.08687083
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08681956
134Hepatitis B_Homo sapiens_hsa051610.06951423
135Linoleic acid metabolism_Homo sapiens_hsa005910.06218662
136Fatty acid degradation_Homo sapiens_hsa000710.05849480
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02535546
138Glycerolipid metabolism_Homo sapiens_hsa00561-0.0535516
139Acute myeloid leukemia_Homo sapiens_hsa05221-0.0454928
140Small cell lung cancer_Homo sapiens_hsa05222-0.0431590
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0385293
142Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0283820
143Measles_Homo sapiens_hsa05162-0.0256416

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