PRAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.39166665
2glutamate secretion (GO:0014047)4.61290595
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57485189
4neuron cell-cell adhesion (GO:0007158)4.46803841
5synaptic vesicle maturation (GO:0016188)4.38090196
6regulation of synaptic vesicle exocytosis (GO:2000300)4.27603630
7vocalization behavior (GO:0071625)4.21535251
8protein localization to synapse (GO:0035418)4.06825897
9negative regulation of synaptic transmission, GABAergic (GO:0032229)4.06127644
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.05149013
11neuronal action potential propagation (GO:0019227)3.92576245
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.84936684
13neurotransmitter secretion (GO:0007269)3.75623751
14dendritic spine morphogenesis (GO:0060997)3.75150654
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.71157242
16chaperone-mediated protein transport (GO:0072321)3.70942422
17protein maturation by protein folding (GO:0022417)3.68095950
18ATP hydrolysis coupled proton transport (GO:0015991)3.67859875
19energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.67859875
20pyrimidine nucleobase catabolic process (GO:0006208)3.66114924
21establishment of mitochondrion localization (GO:0051654)3.64520812
22regulation of synaptic vesicle transport (GO:1902803)3.61956997
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56527788
24negative regulation of dendrite morphogenesis (GO:0050774)3.56180860
25transferrin transport (GO:0033572)3.55524854
26cullin deneddylation (GO:0010388)3.55319736
27neuron-neuron synaptic transmission (GO:0007270)3.47448029
28response to gravity (GO:0009629)3.46115010
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45373971
30regulation of glutamate receptor signaling pathway (GO:1900449)3.43092005
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41206231
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40530782
33protein retention in ER lumen (GO:0006621)3.38310873
34neurotransmitter-gated ion channel clustering (GO:0072578)3.34579680
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33955554
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.31101888
37negative regulation of microtubule polymerization (GO:0031115)3.30310619
38ferric iron transport (GO:0015682)3.28753191
39trivalent inorganic cation transport (GO:0072512)3.28753191
40synaptic transmission, glutamatergic (GO:0035249)3.27060692
41locomotory exploration behavior (GO:0035641)3.22861584
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22637303
43synaptic vesicle endocytosis (GO:0048488)3.17895767
44protein neddylation (GO:0045116)3.17730911
45positive regulation of synapse maturation (GO:0090129)3.16686604
46neuronal ion channel clustering (GO:0045161)3.16343000
47protein deneddylation (GO:0000338)3.15137636
48regulation of neuronal synaptic plasticity (GO:0048168)3.15050061
49positive regulation of mitochondrial fission (GO:0090141)3.14950458
50positive regulation of synapse assembly (GO:0051965)3.13290462
51cell migration in hindbrain (GO:0021535)3.13032910
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.12828622
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09566714
54neurotransmitter transport (GO:0006836)3.09472658
55neuron recognition (GO:0008038)3.09416447
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08335245
57cellular potassium ion homeostasis (GO:0030007)3.08277934
58long-term synaptic potentiation (GO:0060291)3.07427055
59dendritic spine organization (GO:0097061)3.06215489
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04342952
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03122701
62detection of temperature stimulus involved in sensory perception (GO:0050961)3.02849938
63detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.02849938
64synaptic vesicle transport (GO:0048489)3.02222899
65establishment of synaptic vesicle localization (GO:0097480)3.02222899
66presynaptic membrane organization (GO:0097090)3.00801528
67regulation of neurotransmitter secretion (GO:0046928)2.99407184
68glutamate receptor signaling pathway (GO:0007215)2.99071031
69regulation of glutamate secretion (GO:0014048)2.97443675
70presynaptic membrane assembly (GO:0097105)2.95742509
71exploration behavior (GO:0035640)2.95529953
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95160980
73gamma-aminobutyric acid transport (GO:0015812)2.94160761
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92139689
75cerebellar Purkinje cell layer development (GO:0021680)2.92102656
76axon extension (GO:0048675)2.91265786
77regulation of neurotransmitter transport (GO:0051588)2.90652899
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89000527
79postsynaptic membrane organization (GO:0001941)2.88918963
80regulation of synapse structural plasticity (GO:0051823)2.87592666
81neuromuscular process controlling posture (GO:0050884)2.87190421
82negative regulation of dendrite development (GO:2000171)2.87013399
83regulation of neurotransmitter levels (GO:0001505)2.86921793
84ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.86105291
85mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.84787253
86regulation of vesicle fusion (GO:0031338)2.84022209
87regulation of synaptic transmission, GABAergic (GO:0032228)2.83321455
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82988995
89positive regulation of TOR signaling (GO:0032008)2.82462558
90sequestering of actin monomers (GO:0042989)2.82299533
91negative regulation of neurotransmitter transport (GO:0051589)2.80964259
92nucleobase catabolic process (GO:0046113)2.80124555
93synaptic transmission, dopaminergic (GO:0001963)2.78949431
94pattern specification involved in kidney development (GO:0061004)2.78919048
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.77952812
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76848826
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76261257
98mitochondrion transport along microtubule (GO:0047497)2.76261257
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75550750
100ATP synthesis coupled proton transport (GO:0015986)2.75334898
101energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75334898
102regulation of synaptic plasticity (GO:0048167)2.74750277
103synaptic transmission (GO:0007268)2.73889151
104proline transport (GO:0015824)2.73435492
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73097229
106short-term memory (GO:0007614)2.72545494
107type B pancreatic cell proliferation (GO:0044342)2.72465901
108layer formation in cerebral cortex (GO:0021819)2.71256810
109regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.70951228
110regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.70951228
111establishment of vesicle localization (GO:0051650)2.70401366
112auditory behavior (GO:0031223)2.70276003
113innervation (GO:0060384)2.69894186
114axonal fasciculation (GO:0007413)2.69794347
115cerebellar granule cell differentiation (GO:0021707)2.68495356
116regulation of voltage-gated calcium channel activity (GO:1901385)2.67106511
117regulation of respiratory system process (GO:0044065)2.66406032
118synapse assembly (GO:0007416)2.65947920
119negative regulation of cation channel activity (GO:2001258)2.64449856
120neurotransmitter uptake (GO:0001504)2.64417915
121protein heterotrimerization (GO:0070208)2.63070974
122adult walking behavior (GO:0007628)2.62995511
123transmission of nerve impulse (GO:0019226)2.62596127
124regulation of postsynaptic membrane potential (GO:0060078)2.62572348
125regulation of protein kinase A signaling (GO:0010738)2.62176868
126detection of temperature stimulus (GO:0016048)2.61657160
127neuromuscular synaptic transmission (GO:0007274)2.59776097
128base-excision repair, AP site formation (GO:0006285)2.58951095
129positive regulation of membrane potential (GO:0045838)2.58524051
130protein insertion into membrane (GO:0051205)2.58377773
131pyrimidine nucleotide catabolic process (GO:0006244)2.55341641
132positive regulation of neurotransmitter transport (GO:0051590)2.53233324
133regulation of neurotransmitter uptake (GO:0051580)2.52732447
134neuron projection extension (GO:1990138)2.52135922
135protein complex biogenesis (GO:0070271)2.50416632
136regulation of autophagic vacuole assembly (GO:2000785)2.49698443
137regulation of protein targeting to membrane (GO:0090313)2.46411645
138substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45150208
139substrate-independent telencephalic tangential migration (GO:0021826)2.45150208
140neuron projection extension involved in neuron projection guidance (GO:1902284)2.39680718
141axon extension involved in axon guidance (GO:0048846)2.39680718
142negative regulation of axonogenesis (GO:0050771)2.36678167
143left/right pattern formation (GO:0060972)2.34717590
144startle response (GO:0001964)2.33010972
145kidney mesenchyme development (GO:0072074)2.31963205
146sodium ion export (GO:0071436)2.30880522
147calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29706718
148cranial nerve morphogenesis (GO:0021602)2.29565167
149response to auditory stimulus (GO:0010996)2.28631398
150iron-sulfur cluster assembly (GO:0016226)2.28515280
151metallo-sulfur cluster assembly (GO:0031163)2.28515280
152behavioral response to cocaine (GO:0048148)2.28464923
153negative regulation of axon extension (GO:0030517)2.28360238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78007497
2GBX2_23144817_ChIP-Seq_PC3_Human4.11587776
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25170529
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11302870
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93577618
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78800128
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.71835607
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69156261
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64074819
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64074819
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.60671839
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59331460
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57545314
14REST_21632747_ChIP-Seq_MESCs_Mouse2.36206401
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31447750
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29036580
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28683635
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18626277
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14114719
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.06096144
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.05252231
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04087123
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.02694667
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00495585
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.96439768
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96042490
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91834097
28* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86728654
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.86652296
30TAF15_26573619_Chip-Seq_HEK293_Human1.85937712
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85732015
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81715658
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77125636
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76587455
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73403749
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73384844
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69295240
38LXR_22292898_ChIP-Seq_THP-1_Human1.68784085
39AR_21572438_ChIP-Seq_LNCaP_Human1.66960417
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.60886691
41CTCF_27219007_Chip-Seq_Bcells_Human1.55952620
42DROSHA_22980978_ChIP-Seq_HELA_Human1.54044573
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52986664
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51837832
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51691879
46P300_19829295_ChIP-Seq_ESCs_Human1.50572366
47CTCF_18555785_ChIP-Seq_MESCs_Mouse1.44826741
48SMAD4_21799915_ChIP-Seq_A2780_Human1.44532670
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.41695071
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40400679
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39382314
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39250424
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38683896
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.38659364
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38356975
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37991321
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37957945
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37631436
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37279044
60TET1_21490601_ChIP-Seq_MESCs_Mouse1.31748586
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30002492
62* P68_20966046_ChIP-Seq_HELA_Human1.29572789
63VDR_22108803_ChIP-Seq_LS180_Human1.29154844
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27959928
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27364506
66ZNF274_21170338_ChIP-Seq_K562_Hela1.25734707
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.25699214
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25443473
69FUS_26573619_Chip-Seq_HEK293_Human1.24860315
70JUN_21703547_ChIP-Seq_K562_Human1.22450446
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.21624629
72RNF2_27304074_Chip-Seq_NSC_Mouse1.21549816
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.18669881
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18628604
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18428424
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.18137874
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17974454
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.16862985
79CTCF_20526341_ChIP-Seq_ESCs_Human1.15186151
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15092971
81KDM2B_26808549_Chip-Seq_K562_Human1.13884555
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13863814
83* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13156117
84TP53_22127205_ChIP-Seq_IMR90_Human1.11840395
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11588618
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11373991
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10465607
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10453025
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10162406
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.09856072
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.09026540
92* BCL6_27268052_Chip-Seq_Bcells_Human1.08972113
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07989785
94AR_25329375_ChIP-Seq_VCAP_Human1.06808958
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06480406
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06181788
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.03943012
98* ETS1_20019798_ChIP-Seq_JURKAT_Human1.03551386
99ER_23166858_ChIP-Seq_MCF-7_Human1.02158599
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01769435
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99720363
102SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98813070
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98480939
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98319640
105GABP_19822575_ChIP-Seq_HepG2_Human0.98260018
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98100584
107YY1_21170310_ChIP-Seq_MESCs_Mouse0.97793680
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96894675
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96461805
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.95945091
111SOX9_26525672_Chip-Seq_HEART_Mouse0.95465709
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95372033
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93960194
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93550558
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.93358361
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92921250
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.92917164
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.91769700
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91207493
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.91185607
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90133706
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88953206
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88214792
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87945682
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87909087
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87801019
127SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87051361
128NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86807138
129XRN2_22483619_ChIP-Seq_HELA_Human0.86224494
130EWS_26573619_Chip-Seq_HEK293_Human0.85999123
131SA1_27219007_Chip-Seq_Bcells_Human0.85434098
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84828003
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84328342
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83966107
135SA1_22415368_ChIP-Seq_MEFs_Mouse0.82785758
136TP53_18474530_ChIP-ChIP_U2OS_Human0.82629308
137GABP_17652178_ChIP-ChIP_JURKAT_Human0.82574255
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82571789
139* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82474658
140SMC4_20622854_ChIP-Seq_HELA_Human0.82325781
141STAT3_23295773_ChIP-Seq_U87_Human0.81335294
142AR_19668381_ChIP-Seq_PC3_Human0.81144742
143EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80950235
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80866061
145IGF1R_20145208_ChIP-Seq_DFB_Human0.80274375
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80237807
147RUNX2_22187159_ChIP-Seq_PCA_Human0.79849650
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79360841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.31989208
2MP0003880_abnormal_central_pattern4.07213340
3MP0001968_abnormal_touch/_nociception3.51446073
4MP0002736_abnormal_nociception_after3.39809957
5MP0003635_abnormal_synaptic_transmissio3.21233980
6MP0004270_analgesia3.11587255
7MP0002735_abnormal_chemical_nociception2.99670935
8MP0009046_muscle_twitch2.91570142
9MP0002064_seizures2.81840930
10MP0002734_abnormal_mechanical_nocicepti2.76786945
11MP0009745_abnormal_behavioral_response2.74680354
12MP0002063_abnormal_learning/memory/cond2.58727037
13MP0003122_maternal_imprinting2.51457532
14MP0002272_abnormal_nervous_system2.47548129
15MP0002572_abnormal_emotion/affect_behav2.33416283
16MP0006276_abnormal_autonomic_nervous2.33397182
17MP0001529_abnormal_vocalization2.28715533
18MP0002733_abnormal_thermal_nociception2.25170600
19MP0001970_abnormal_pain_threshold2.16737197
20MP0002822_catalepsy2.05760797
21MP0004858_abnormal_nervous_system2.00880425
22MP0001486_abnormal_startle_reflex1.94186089
23MP0001905_abnormal_dopamine_level1.92972722
24MP0005503_abnormal_tendon_morphology1.88716563
25MP0002067_abnormal_sensory_capabilities1.87139232
26MP0002184_abnormal_innervation1.86834184
27MP0004142_abnormal_muscle_tone1.82055906
28MP0008789_abnormal_olfactory_epithelium1.75214483
29MP0001440_abnormal_grooming_behavior1.71427055
30MP0005423_abnormal_somatic_nervous1.70027754
31MP0000778_abnormal_nervous_system1.67252325
32MP0001984_abnormal_olfaction1.56163515
33MP0005257_abnormal_intraocular_pressure1.55848072
34MP0001986_abnormal_taste_sensitivity1.53964580
35MP0001501_abnormal_sleep_pattern1.53921674
36MP0001958_emphysema1.52940963
37MP0004811_abnormal_neuron_physiology1.52286019
38MP0000955_abnormal_spinal_cord1.49088825
39MP0004924_abnormal_behavior1.47828176
40MP0005386_behavior/neurological_phenoty1.47828176
41MP0008569_lethality_at_weaning1.46737734
42MP0001188_hyperpigmentation1.44724226
43MP0005171_absent_coat_pigmentation1.42924184
44MP0008438_abnormal_cutaneous_collagen1.40765964
45MP0002557_abnormal_social/conspecific_i1.39597318
46MP0002882_abnormal_neuron_morphology1.35960911
47MP0003787_abnormal_imprinting1.32334340
48MP0003329_amyloid_beta_deposits1.29616312
49MP0005646_abnormal_pituitary_gland1.29135560
50MP0002066_abnormal_motor_capabilities/c1.25891641
51MP0005623_abnormal_meninges_morphology1.24383667
52MP0002295_abnormal_pulmonary_circulatio1.24206090
53MP0009780_abnormal_chondrocyte_physiolo1.21760082
54MP0000751_myopathy1.21013332
55MP0009384_cardiac_valve_regurgitation1.16070197
56MP0002653_abnormal_ependyma_morphology1.15286620
57MP0002751_abnormal_autonomic_nervous1.14791838
58MP0003011_delayed_dark_adaptation1.10465611
59MP0005508_abnormal_skeleton_morphology1.09671666
60MP0003121_genomic_imprinting1.05369350
61MP0004233_abnormal_muscle_weight1.04966065
62MP0000750_abnormal_muscle_regeneration1.03392456
63MP0002249_abnormal_larynx_morphology1.02894910
64MP0002102_abnormal_ear_morphology1.02805714
65MP0000639_abnormal_adrenal_gland0.98893419
66MP0002152_abnormal_brain_morphology0.96486465
67MP0002752_abnormal_somatic_nervous0.95287666
68MP0003879_abnormal_hair_cell0.94871383
69MP0003634_abnormal_glial_cell0.92456649
70MP0001299_abnormal_eye_distance/0.92313585
71MP0002638_abnormal_pupillary_reflex0.91241936
72MP0005551_abnormal_eye_electrophysiolog0.90389441
73MP0004134_abnormal_chest_morphology0.90004769
74MP0004742_abnormal_vestibular_system0.89840008
75MP0003123_paternal_imprinting0.86998806
76MP0001963_abnormal_hearing_physiology0.85255564
77MP0010386_abnormal_urinary_bladder0.84988907
78MP0004133_heterotaxia0.84673286
79MP0003283_abnormal_digestive_organ0.84610387
80MP0000534_abnormal_ureter_morphology0.84457006
81MP0001542_abnormal_bone_strength0.84443423
82MP0000013_abnormal_adipose_tissue0.84357096
83MP0010030_abnormal_orbit_morphology0.83414144
84MP0008872_abnormal_physiological_respon0.83288076
85MP0002229_neurodegeneration0.82771900
86MP0006292_abnormal_olfactory_placode0.82221936
87MP0003631_nervous_system_phenotype0.82086102
88MP0001502_abnormal_circadian_rhythm0.82065405
89MP0009250_abnormal_appendicular_skeleto0.80334466
90MP0003633_abnormal_nervous_system0.80264891
91MP0003279_aneurysm0.79686461
92MP0005499_abnormal_olfactory_system0.78711277
93MP0005394_taste/olfaction_phenotype0.78711277
94MP0001177_atelectasis0.78703317
95MP0000920_abnormal_myelination0.78049106
96MP0002837_dystrophic_cardiac_calcinosis0.77100415
97MP0005367_renal/urinary_system_phenotyp0.74063076
98MP0000516_abnormal_urinary_system0.74063076
99MP0002932_abnormal_joint_morphology0.74004818
100MP0000631_abnormal_neuroendocrine_gland0.73957295
101MP0001270_distended_abdomen0.72989744
102MP0004085_abnormal_heartbeat0.72702297
103MP0000681_abnormal_thyroid_gland0.72077609
104MP0001943_abnormal_respiration0.70735271
105MP0005645_abnormal_hypothalamus_physiol0.70054348
106MP0002090_abnormal_vision0.69918746
107MP0003942_abnormal_urinary_system0.69569236
108MP0000749_muscle_degeneration0.68994663
109MP0001664_abnormal_digestion0.68911957
110MP0003861_abnormal_nervous_system0.68860045
111MP0004885_abnormal_endolymph0.68510197
112MP0003632_abnormal_nervous_system0.67707714
113MP0002909_abnormal_adrenal_gland0.67706613
114MP0009379_abnormal_foot_pigmentation0.67567481
115MP0002928_abnormal_bile_duct0.66572020
116MP0000049_abnormal_middle_ear0.65822325
117MP0002108_abnormal_muscle_morphology0.65702882
118MP0005595_abnormal_vascular_smooth0.64157667
119MP0003385_abnormal_body_wall0.62115976
120MP0000372_irregular_coat_pigmentation0.62011859
121MP0000026_abnormal_inner_ear0.61786779
122MP0002069_abnormal_eating/drinking_beha0.61101634

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.83849230
2Focal motor seizures (HP:0011153)5.75221404
3Atonic seizures (HP:0010819)4.57405212
4Epileptic encephalopathy (HP:0200134)4.13002298
5Focal seizures (HP:0007359)4.06939188
6Pheochromocytoma (HP:0002666)3.80095995
7Febrile seizures (HP:0002373)3.59291056
8Neuroendocrine neoplasm (HP:0100634)3.52599512
9Limb dystonia (HP:0002451)3.50962686
10Progressive cerebellar ataxia (HP:0002073)3.42537807
11Absence seizures (HP:0002121)3.34327407
12Acute necrotizing encephalopathy (HP:0006965)3.18654004
13Visual hallucinations (HP:0002367)3.15091006
14Hand muscle atrophy (HP:0009130)3.14690594
15Dialeptic seizures (HP:0011146)3.09421423
16Abnormal hair whorl (HP:0010721)3.09354007
17Abnormal mitochondria in muscle tissue (HP:0008316)2.95687278
18Progressive macrocephaly (HP:0004481)2.66336457
19Gait imbalance (HP:0002141)2.63922913
20Distal upper limb amyotrophy (HP:0007149)2.62279505
21Upper limb amyotrophy (HP:0009129)2.62279505
22Mitochondrial inheritance (HP:0001427)2.57312580
23Generalized tonic-clonic seizures (HP:0002069)2.56341761
24Failure to thrive in infancy (HP:0001531)2.55780386
25Ankle clonus (HP:0011448)2.53677993
26Abnormality of binocular vision (HP:0011514)2.53421653
27Diplopia (HP:0000651)2.53421653
28Abnormality of glycolysis (HP:0004366)2.51100939
29Increased serum pyruvate (HP:0003542)2.51100939
30Narrow nasal bridge (HP:0000446)2.50598145
31Hypoventilation (HP:0002791)2.47371595
32Cerebral hypomyelination (HP:0006808)2.44082334
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42841213
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42841213
35Congenital primary aphakia (HP:0007707)2.41616999
36Bladder diverticulum (HP:0000015)2.40599313
37Hyperventilation (HP:0002883)2.39296548
38Hyperthyroidism (HP:0000836)2.39161027
39Action tremor (HP:0002345)2.38080464
40Abnormal eating behavior (HP:0100738)2.34206260
41Poor suck (HP:0002033)2.33806883
42Abnormality of the labia minora (HP:0012880)2.33437079
43Genital tract atresia (HP:0001827)2.30350503
44Medial flaring of the eyebrow (HP:0010747)2.26420806
45Ankle contracture (HP:0006466)2.25215145
46Neoplasm of the peripheral nervous system (HP:0100007)2.25142034
47Polyphagia (HP:0002591)2.22826033
48Nephrogenic diabetes insipidus (HP:0009806)2.22557246
49Vaginal atresia (HP:0000148)2.21953280
50Progressive inability to walk (HP:0002505)2.21236658
51Abnormality of dentin (HP:0010299)2.17537010
52Broad-based gait (HP:0002136)2.16950161
53Genu recurvatum (HP:0002816)2.16330159
54Increased CSF lactate (HP:0002490)2.15775356
55Hepatocellular necrosis (HP:0001404)2.15138881
56Hemiparesis (HP:0001269)2.13765851
57Retinal dysplasia (HP:0007973)2.13370319
58Delusions (HP:0000746)2.13314047
59Impaired pain sensation (HP:0007328)2.12198901
60Abnormality of pain sensation (HP:0010832)2.12198901
61Amblyopia (HP:0000646)2.11887413
62Agitation (HP:0000713)2.11845513
63Protrusio acetabuli (HP:0003179)2.11274140
64Acute encephalopathy (HP:0006846)2.09627438
65Anxiety (HP:0000739)2.08971402
66Spastic tetraplegia (HP:0002510)2.05634216
67Termporal pattern (HP:0011008)2.05549441
68Insidious onset (HP:0003587)2.05549441
69Truncal ataxia (HP:0002078)2.04865030
70Supranuclear gaze palsy (HP:0000605)2.04069761
71Leukodystrophy (HP:0002415)2.03940976
72Spinal rigidity (HP:0003306)2.03468364
73Occipital encephalocele (HP:0002085)2.01956765
74Hypothermia (HP:0002045)2.01139291
75Scanning speech (HP:0002168)2.01039615
76Specific learning disability (HP:0001328)2.00031900
77Insomnia (HP:0100785)1.99894733
78Bowel diverticulosis (HP:0005222)1.96649021
79Dysdiadochokinesis (HP:0002075)1.95834246
80Dysmetria (HP:0001310)1.95165575
81Fetal akinesia sequence (HP:0001989)1.93798855
82Epileptiform EEG discharges (HP:0011182)1.92248245
83Atelectasis (HP:0100750)1.91077938
84Abnormality of the pulmonary veins (HP:0011718)1.91052123
85Infantile muscular hypotonia (HP:0008947)1.90925527
86Hypoplasia of the brainstem (HP:0002365)1.89806604
87Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89806604
88Abnormality of the corticospinal tract (HP:0002492)1.87039021
89Intention tremor (HP:0002080)1.86663517
90Anomalous pulmonary venous return (HP:0010772)1.85477664
91Opisthotonus (HP:0002179)1.85437840
92Focal dystonia (HP:0004373)1.85037636
93Generalized hypotonia (HP:0001290)1.84947073
94Depression (HP:0000716)1.84590658
95Torticollis (HP:0000473)1.84395513
96Amyotrophic lateral sclerosis (HP:0007354)1.84184615
97Mitral regurgitation (HP:0001653)1.83419461
98Delayed gross motor development (HP:0002194)1.83096618
99Impaired vibration sensation in the lower limbs (HP:0002166)1.81140224
100Irregular epiphyses (HP:0010582)1.80295683
101Esotropia (HP:0000565)1.80197809
102Hydroureter (HP:0000072)1.79240709
103EEG with generalized epileptiform discharges (HP:0011198)1.78627112
104Spastic gait (HP:0002064)1.78329552
105Congenital glaucoma (HP:0001087)1.77946287
106Bradycardia (HP:0001662)1.77907187
107Hepatic necrosis (HP:0002605)1.77739642
108Aplasia/Hypoplasia of the lens (HP:0008063)1.77717461
109Optic disc pallor (HP:0000543)1.77420031
110Abnormality of the lower motor neuron (HP:0002366)1.76934163
111Sclerocornea (HP:0000647)1.76546912
112Myotonia (HP:0002486)1.76398758
113Adrenal hypoplasia (HP:0000835)1.76037933
114Autoamputation (HP:0001218)1.75599928
115Hypercortisolism (HP:0001578)1.72352796
116Slender build (HP:0001533)1.72214039
117Ulnar claw (HP:0001178)1.71782127
118Postnatal microcephaly (HP:0005484)1.71753926
119Cutaneous melanoma (HP:0012056)1.71327992
120Follicular hyperkeratosis (HP:0007502)1.70961627
121Cholecystitis (HP:0001082)1.69478144
122Abnormal gallbladder physiology (HP:0012438)1.69478144
123Craniofacial dystonia (HP:0012179)1.68795109
124Emotional lability (HP:0000712)1.68794631
125Sensory axonal neuropathy (HP:0003390)1.68721345
126Hypoplastic left heart (HP:0004383)1.68131520
127Incomplete penetrance (HP:0003829)1.67897457
128Lissencephaly (HP:0001339)1.67877234
129Hypsarrhythmia (HP:0002521)1.67753993
130Megalencephaly (HP:0001355)1.67146364
131Lower limb muscle weakness (HP:0007340)1.67006253
132Vertebral compression fractures (HP:0002953)1.66606721
133Poor coordination (HP:0002370)1.66050689
134Soft skin (HP:0000977)1.65416785
135Gaze-evoked nystagmus (HP:0000640)1.65372862
136Broad distal phalanx of finger (HP:0009836)1.64266856
137Premature rupture of membranes (HP:0001788)1.63262863
138Inability to walk (HP:0002540)1.62926259
139Akinesia (HP:0002304)1.62044603
140Annular pancreas (HP:0001734)1.61520657
141Neurofibrillary tangles (HP:0002185)1.61445324
142Aortic dissection (HP:0002647)1.60621095
143Molar tooth sign on MRI (HP:0002419)1.59823821
144Abnormality of midbrain morphology (HP:0002418)1.59823821
145Upper limb muscle weakness (HP:0003484)1.59662258
146Heterochromia iridis (HP:0001100)1.59480007
147Growth hormone excess (HP:0000845)1.58824278
148Shallow orbits (HP:0000586)1.58741435
149Urinary urgency (HP:0000012)1.58176243
150Unsteady gait (HP:0002317)1.58017584
151Sleep apnea (HP:0010535)1.56637048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.94470135
2MAP3K123.47038429
3NTRK33.07496074
4MINK12.73053853
5PLK22.56997574
6ARAF2.50557162
7LIMK12.48158761
8MAP3K92.34664778
9EPHA42.33518046
10CDK192.33126548
11BCKDK2.31560027
12PRPF4B2.16529233
13MARK12.14813783
14GRK52.11444800
15MAP2K72.10829834
16SIK32.10746091
17MAP3K112.03910289
18MAP3K41.92030582
19NME11.81340903
20NTRK11.65860171
21DAPK21.64680738
22BCR1.63854838
23AKT31.56969852
24PAK61.55544160
25PRKD21.54797011
26LATS21.50549620
27TESK21.47881441
28VRK21.47028706
29BRAF1.46386547
30OXSR11.43906141
31DAPK11.42624919
32KSR11.39932080
33CDK141.39040651
34TESK11.36645982
35KSR21.35412773
36CDK181.35403234
37MAPK131.29446684
38PINK11.27765205
39DYRK1B1.26966459
40CDK151.23715195
41NTRK21.23393102
42CSNK1A1L1.20594526
43PRKCG1.18317788
44TSSK61.17188365
45CDK51.17071305
46UHMK11.12219405
47CSNK1G11.11875576
48SGK4941.10842141
49SGK2231.10842141
50DDR21.10728831
51CDK11A1.09869150
52CAMK2B1.09483208
53ABL21.07936167
54MAP4K21.07269642
55MAP2K41.05888970
56CAMK2A1.05527502
57PTK2B1.05347458
58MYLK1.02356492
59ROCK21.00637714
60MARK20.97625574
61ADRBK20.94643032
62EPHB10.92698312
63DAPK30.89783587
64PRKD30.86279868
65ADRBK10.85347557
66STK380.83785987
67PTK20.83176120
68TAOK20.81254053
69PRKCE0.80553219
70NEK10.79792230
71CAMK2D0.79626112
72DYRK20.78140475
73ERBB30.78082803
74PHKG10.77781125
75PHKG20.77781125
76MAPKAPK50.77028643
77RPS6KA20.76143098
78LRRK20.74107058
79TRIM280.73752804
80MAP2K10.73289462
81CAMK2G0.73150997
82CSNK1G30.72864513
83FER0.72693881
84CSNK1G20.72189862
85CAMKK20.71049210
86GRK70.67399797
87PLK30.66712071
88CDK80.66655970
89LMTK20.66632659
90TNK20.65224738
91PKN10.65063732
92CCNB10.63925627
93AURKA0.63498269
94PIM20.63431132
95CAMKK10.62762389
96STK390.61945502
97PRKD10.61388712
98SGK20.60966582
99PAK30.58621486
100BMPR1B0.53625146
101DYRK30.52454179
102DYRK1A0.51803118
103BUB10.50975675
104EPHA30.50965411
105KDR0.50812775
106PNCK0.50760900
107TAOK10.49959948
108MOS0.49584556
109BMPR20.48407061
110TYRO30.46803949
111WNK40.46257356
112STK110.46251091
113RIPK40.44702277
114STK160.44320852
115ROCK10.44304997
116HIPK20.43440573
117NEK60.42620915
118PRKCI0.41761426
119ICK0.40134751
120EPHB20.39018269
121YES10.38217502
122ERBB40.36729917
123BRSK10.36419702
124PRKCH0.36219689
125PAK10.36138422
126SIK20.34801112
127PRKACA0.33112812
128ILK0.32711559
129CAMK10.31891837
130RAF10.30734901
131PRKCZ0.30215918

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.12613613
2Nicotine addiction_Homo sapiens_hsa050333.34953880
3Collecting duct acid secretion_Homo sapiens_hsa049663.04307646
4Oxidative phosphorylation_Homo sapiens_hsa001902.96679006
5Parkinsons disease_Homo sapiens_hsa050122.48415052
6GABAergic synapse_Homo sapiens_hsa047272.45461949
7Sulfur relay system_Homo sapiens_hsa041222.38144725
8Vibrio cholerae infection_Homo sapiens_hsa051102.36572167
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36501489
10Olfactory transduction_Homo sapiens_hsa047402.32470043
11Circadian entrainment_Homo sapiens_hsa047132.13607836
12Morphine addiction_Homo sapiens_hsa050322.11918825
13Dopaminergic synapse_Homo sapiens_hsa047281.99514311
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92371084
15Alzheimers disease_Homo sapiens_hsa050101.91298235
16Glutamatergic synapse_Homo sapiens_hsa047241.87971323
17Amphetamine addiction_Homo sapiens_hsa050311.84694571
18Long-term potentiation_Homo sapiens_hsa047201.83069641
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82945459
20Serotonergic synapse_Homo sapiens_hsa047261.82762304
21Huntingtons disease_Homo sapiens_hsa050161.70840075
22Cardiac muscle contraction_Homo sapiens_hsa042601.67841416
23Taste transduction_Homo sapiens_hsa047421.63895816
24Folate biosynthesis_Homo sapiens_hsa007901.63349834
25Proteasome_Homo sapiens_hsa030501.57363131
26Long-term depression_Homo sapiens_hsa047301.55361241
27Salivary secretion_Homo sapiens_hsa049701.52703900
28Cholinergic synapse_Homo sapiens_hsa047251.52564013
29Cocaine addiction_Homo sapiens_hsa050301.48180804
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40455357
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38846796
32Gap junction_Homo sapiens_hsa045401.38630956
33Insulin secretion_Homo sapiens_hsa049111.36121077
34Ribosome_Homo sapiens_hsa030101.26619926
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24340574
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19058800
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17802160
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16716488
39Axon guidance_Homo sapiens_hsa043601.15715904
40Calcium signaling pathway_Homo sapiens_hsa040201.14601958
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11445311
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11156854
43Rheumatoid arthritis_Homo sapiens_hsa053231.10510764
44Gastric acid secretion_Homo sapiens_hsa049711.10509299
45Phototransduction_Homo sapiens_hsa047441.08923343
46Oxytocin signaling pathway_Homo sapiens_hsa049211.05989576
47Phagosome_Homo sapiens_hsa041451.03538781
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02382583
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02057449
50Renin secretion_Homo sapiens_hsa049240.99748197
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99272806
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96801539
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.96561423
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89968361
55GnRH signaling pathway_Homo sapiens_hsa049120.89399613
56Melanogenesis_Homo sapiens_hsa049160.85846129
57Oocyte meiosis_Homo sapiens_hsa041140.83233927
58Basal cell carcinoma_Homo sapiens_hsa052170.82674089
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79840454
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78926328
61ErbB signaling pathway_Homo sapiens_hsa040120.77277667
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76522986
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.74785539
64Regulation of autophagy_Homo sapiens_hsa041400.72666479
65Glioma_Homo sapiens_hsa052140.71807437
66Notch signaling pathway_Homo sapiens_hsa043300.69403286
67Dilated cardiomyopathy_Homo sapiens_hsa054140.65179283
68Hedgehog signaling pathway_Homo sapiens_hsa043400.64944623
69Alcoholism_Homo sapiens_hsa050340.64207253
70cAMP signaling pathway_Homo sapiens_hsa040240.61825667
71Shigellosis_Homo sapiens_hsa051310.61601644
72Estrogen signaling pathway_Homo sapiens_hsa049150.61560263
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60652967
74Melanoma_Homo sapiens_hsa052180.60505930
75Ras signaling pathway_Homo sapiens_hsa040140.56730603
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56693187
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53138832
78N-Glycan biosynthesis_Homo sapiens_hsa005100.53010327
79Endocytosis_Homo sapiens_hsa041440.51966761
80Biosynthesis of amino acids_Homo sapiens_hsa012300.51432134
81Salmonella infection_Homo sapiens_hsa051320.50234109
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50148698
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49762896
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49530296
85Rap1 signaling pathway_Homo sapiens_hsa040150.49360633
86Prion diseases_Homo sapiens_hsa050200.48538519
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48411543
88ECM-receptor interaction_Homo sapiens_hsa045120.48359290
89MAPK signaling pathway_Homo sapiens_hsa040100.48115456
90Wnt signaling pathway_Homo sapiens_hsa043100.46839512
91Thyroid hormone synthesis_Homo sapiens_hsa049180.46012030
92Hippo signaling pathway_Homo sapiens_hsa043900.45530276
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45183554
94Steroid biosynthesis_Homo sapiens_hsa001000.44881712
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.42657109
96RNA polymerase_Homo sapiens_hsa030200.41640295
97AMPK signaling pathway_Homo sapiens_hsa041520.40547679
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40059713
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39633361
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.39166609
101Tight junction_Homo sapiens_hsa045300.38573951
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37985231
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.36101811
104Glutathione metabolism_Homo sapiens_hsa004800.36079603
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34854812
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34411562
107Type I diabetes mellitus_Homo sapiens_hsa049400.34239994
108Metabolic pathways_Homo sapiens_hsa011000.34222609
109VEGF signaling pathway_Homo sapiens_hsa043700.33758290
110Renal cell carcinoma_Homo sapiens_hsa052110.32312911
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32111786
112Fatty acid elongation_Homo sapiens_hsa000620.31181874
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30878985
114Fructose and mannose metabolism_Homo sapiens_hsa000510.30427178
115Bladder cancer_Homo sapiens_hsa052190.30186768
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29768536
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27860712
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27597251
119Protein export_Homo sapiens_hsa030600.26618604
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24319478
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22375423
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22126836
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21952124
124Pyruvate metabolism_Homo sapiens_hsa006200.21813079

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