PRAME

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.14117739
2sperm-egg recognition (GO:0035036)8.92075785
3cell wall macromolecule catabolic process (GO:0016998)8.53995379
4cell wall macromolecule metabolic process (GO:0044036)8.53995379
5binding of sperm to zona pellucida (GO:0007339)8.47808116
6acrosome reaction (GO:0007340)8.41782388
7spermatid development (GO:0007286)8.16457545
8axonemal dynein complex assembly (GO:0070286)7.95266852
9chromosome organization involved in meiosis (GO:0070192)7.95208016
10cilium or flagellum-dependent cell motility (GO:0001539)7.94539977
11cell-cell recognition (GO:0009988)7.93722607
12male meiosis I (GO:0007141)7.79296859
13epithelial cilium movement (GO:0003351)7.78307997
14multicellular organism reproduction (GO:0032504)7.74216374
15plasma membrane fusion (GO:0045026)7.61782718
16meiotic nuclear division (GO:0007126)7.42344913
17cilium movement (GO:0003341)6.88701290
18reproduction (GO:0000003)6.46013966
19regulation of cilium movement (GO:0003352)6.44334857
20meiosis I (GO:0007127)6.43014230
21motile cilium assembly (GO:0044458)6.37524587
22spermatogenesis (GO:0007283)6.26863165
23male gamete generation (GO:0048232)6.25999348
24regulation of translational fidelity (GO:0006450)6.07505452
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.00487166
26microtubule depolymerization (GO:0007019)5.98266163
27regulation of meiosis I (GO:0060631)5.94694874
28gamete generation (GO:0007276)5.76561955
29pore complex assembly (GO:0046931)5.57504521
30germ cell development (GO:0007281)5.43801570
31single fertilization (GO:0007338)5.38848645
32fertilization (GO:0009566)5.37955342
33DNA replication checkpoint (GO:0000076)5.29547441
34meiotic cell cycle process (GO:1903046)5.26836852
35DNA topological change (GO:0006265)5.26418175
36sperm capacitation (GO:0048240)5.25083111
37ventricular system development (GO:0021591)5.04972877
38negative regulation of inclusion body assembly (GO:0090084)5.04668654
39DNA unwinding involved in DNA replication (GO:0006268)4.97453007
40reciprocal DNA recombination (GO:0035825)4.96956924
41reciprocal meiotic recombination (GO:0007131)4.96956924
42cellular process involved in reproduction in multicellular organism (GO:0022412)4.95854519
43mitotic nuclear envelope disassembly (GO:0007077)4.68231940
44meiotic chromosome segregation (GO:0045132)4.66644192
45DNA replication initiation (GO:0006270)4.62809354
46mitotic sister chromatid segregation (GO:0000070)4.57023947
47protoporphyrinogen IX metabolic process (GO:0046501)4.56782891
48DNA packaging (GO:0006323)4.53815802
49multicellular organismal reproductive process (GO:0048609)4.51804203
50regulation of histone H3-K27 methylation (GO:0061085)4.50883782
51formation of translation preinitiation complex (GO:0001731)4.50009222
52regulation of RNA export from nucleus (GO:0046831)4.49115565
53organic cation transport (GO:0015695)4.45371664
54gene silencing by RNA (GO:0031047)4.44757198
55sister chromatid segregation (GO:0000819)4.42908640
56diterpenoid biosynthetic process (GO:0016102)4.36631404
57nuclear envelope disassembly (GO:0051081)4.35270570
58membrane disassembly (GO:0030397)4.35270570
59chromosome condensation (GO:0030261)4.31008328
60regulation of histone H3-K4 methylation (GO:0051569)4.30844503
61protein localization to cilium (GO:0061512)4.26689293
62mitotic chromosome condensation (GO:0007076)4.19791718
63gas transport (GO:0015669)4.15175146
64DNA strand elongation involved in DNA replication (GO:0006271)4.13932981
65meiotic cell cycle (GO:0051321)4.05096822
66DNA strand elongation (GO:0022616)4.01157441
67protoporphyrinogen IX biosynthetic process (GO:0006782)3.95304005
68oogenesis (GO:0048477)3.94748267
69calcium ion-dependent exocytosis (GO:0017156)3.94744367
70DNA alkylation (GO:0006305)3.90638403
71DNA methylation (GO:0006306)3.90638403
72regulation of inclusion body assembly (GO:0090083)3.88136690
73monoubiquitinated protein deubiquitination (GO:0035520)3.86290512
74cell recognition (GO:0008037)3.84581423
75tRNA aminoacylation for protein translation (GO:0006418)3.82472671
76oxygen transport (GO:0015671)3.81242538
77regulation of microtubule-based movement (GO:0060632)3.80598397
78homocysteine metabolic process (GO:0050667)3.79687430
79proline biosynthetic process (GO:0006561)3.79453201
80synapsis (GO:0007129)3.79038415
81terpenoid biosynthetic process (GO:0016114)3.78738545
82telomere maintenance via semi-conservative replication (GO:0032201)3.70153536
83regulation of nucleobase-containing compound transport (GO:0032239)3.66875892
84amino acid activation (GO:0043038)3.66586546
85tRNA aminoacylation (GO:0043039)3.66586546
86nucleoside diphosphate phosphorylation (GO:0006165)3.65888975
87regulation of mitotic spindle organization (GO:0060236)3.65337444
88regulation of translational elongation (GO:0006448)3.63835209
89glycerol ether metabolic process (GO:0006662)3.63318908
90purine nucleobase biosynthetic process (GO:0009113)3.60032036
91sister chromatid cohesion (GO:0007062)3.59914627
92left/right axis specification (GO:0070986)3.58786125
93attachment of spindle microtubules to kinetochore (GO:0008608)3.56455783
94vitamin A metabolic process (GO:0006776)3.56348300
95microtubule severing (GO:0051013)3.56138807
96multicellular organismal development (GO:0007275)3.55557981
97positive regulation of meiosis (GO:0045836)3.55308948
98chaperone-mediated protein complex assembly (GO:0051131)3.52486180
99positive regulation of meiotic cell cycle (GO:0051446)3.50771381
100COPI coating of Golgi vesicle (GO:0048205)3.50733008
101Golgi transport vesicle coating (GO:0048200)3.50733008
102oxidative phosphorylation (GO:0006119)3.49863095
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49689506
104microtubule polymerization or depolymerization (GO:0031109)3.46525907
105chromosome segregation (GO:0007059)3.41443007
106seminiferous tubule development (GO:0072520)3.39687149
107protein export from nucleus (GO:0006611)3.38987082
108erythrocyte maturation (GO:0043249)3.38181292
109negative regulation of erythrocyte differentiation (GO:0045647)3.37762806
110regulation of histone methylation (GO:0031060)3.35653541
111positive regulation of translational initiation (GO:0045948)3.33754731
112folic acid-containing compound biosynthetic process (GO:0009396)3.33011380
113negative regulation of histone methylation (GO:0031061)3.32949108
114nucleobase biosynthetic process (GO:0046112)3.32696696
115ether metabolic process (GO:0018904)3.31981916
116regulation of spindle checkpoint (GO:0090231)3.31961363
117melanin biosynthetic process (GO:0042438)3.30878874
118IMP biosynthetic process (GO:0006188)3.26802884
119resolution of meiotic recombination intermediates (GO:0000712)3.25095813
120tetrahydrofolate metabolic process (GO:0046653)3.24444603
121nuclear envelope organization (GO:0006998)3.24176392
122mitotic sister chromatid cohesion (GO:0007064)3.23342349
123mitotic recombination (GO:0006312)3.21729809
124telomere maintenance via recombination (GO:0000722)3.21002380
125gene silencing (GO:0016458)3.17393003
126kinetochore organization (GO:0051383)3.17316110
127oxaloacetate metabolic process (GO:0006107)3.17098189
128DNA synthesis involved in DNA repair (GO:0000731)3.16016561
129protein localization to kinetochore (GO:0034501)3.12930125
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12484508
131DNA conformation change (GO:0071103)3.11217091
132nuclear pore complex assembly (GO:0051292)3.11171764
133response to vitamin A (GO:0033189)3.10772224
134GTP biosynthetic process (GO:0006183)3.09068665
135definitive hemopoiesis (GO:0060216)3.08897072
136ribosome biogenesis (GO:0042254)3.06015179
137granulocyte differentiation (GO:0030851)3.04457658
138erythrocyte development (GO:0048821)3.02841457
139regulation of histone H3-K9 methylation (GO:0051570)3.01742849
140intra-S DNA damage checkpoint (GO:0031573)3.00786167
141cellular response to interferon-alpha (GO:0035457)2.96520375
142sex differentiation (GO:0007548)2.96388581
143DNA duplex unwinding (GO:0032508)2.96358690
144creatine metabolic process (GO:0006600)2.93950195
145DNA methylation or demethylation (GO:0044728)2.92395931
146melanin metabolic process (GO:0006582)2.90496125
147DNA geometric change (GO:0032392)2.89986805
148IMP metabolic process (GO:0046040)2.88044352
149proteasome assembly (GO:0043248)2.87759518
150histone exchange (GO:0043486)2.86733906
151sensory perception of smell (GO:0007608)2.85843183
152folic acid metabolic process (GO:0046655)2.85639027
153pigment biosynthetic process (GO:0046148)2.85476238
154protein K11-linked deubiquitination (GO:0035871)2.85226333
155viral mRNA export from host cell nucleus (GO:0046784)2.82871988
156ribonucleoprotein complex biogenesis (GO:0022613)2.80846704
157negative regulation of fatty acid biosynthetic process (GO:0045717)2.80756028
158mitotic metaphase plate congression (GO:0007080)2.80596125
159UTP biosynthetic process (GO:0006228)2.79911224
160regulation of centriole replication (GO:0046599)2.78600812
161nuclear pore organization (GO:0006999)2.77784779
162mRNA transport (GO:0051028)2.76930800
163left/right pattern formation (GO:0060972)2.76460813
164regulation of spindle organization (GO:0090224)2.76347979
165ribosomal small subunit assembly (GO:0000028)2.76004164
166chromosome organization (GO:0051276)2.74886672
167kinetochore assembly (GO:0051382)2.74873834
168CDP-diacylglycerol biosynthetic process (GO:0016024)2.73450204
169ribosomal large subunit biogenesis (GO:0042273)2.73371552
170positive regulation of histone methylation (GO:0031062)2.72115678
171regulation of centrosome cycle (GO:0046605)2.71617126
172positive regulation of DNA-dependent DNA replication (GO:2000105)2.70546217
173natural killer cell mediated cytotoxicity (GO:0042267)2.70347022
174natural killer cell mediated immunity (GO:0002228)2.70347022
175DNA damage induced protein phosphorylation (GO:0006975)2.68722256
176genitalia morphogenesis (GO:0035112)2.67958071
177negative regulation of organelle assembly (GO:1902116)2.66379642
178oocyte development (GO:0048599)2.65828729
179oocyte maturation (GO:0001556)2.64836778
180protein localization to chromosome, centromeric region (GO:0071459)2.63669187
181spermatid nucleus differentiation (GO:0007289)2.62843955
182piRNA metabolic process (GO:0034587)13.2267448
183synaptonemal complex assembly (GO:0007130)11.8366530
184synaptonemal complex organization (GO:0070193)11.3496947
185sperm motility (GO:0030317)10.9889450
186male meiosis (GO:0007140)10.5533872
187fusion of sperm to egg plasma membrane (GO:0007342)10.1256697
188DNA methylation involved in gamete generation (GO:0043046)10.0550995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.82882751
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.60083277
3EZH2_22144423_ChIP-Seq_EOC_Human4.37378772
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.21718246
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49789916
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.45149737
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.38762680
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27250929
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.16244085
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.93261152
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85959216
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81030839
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75329238
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74757889
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.68388382
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65590871
17* NCOR1_26117541_ChIP-Seq_K562_Human2.57695985
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57610637
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56961745
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46462318
21XRN2_22483619_ChIP-Seq_HELA_Human2.43383267
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38505538
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.36671487
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34220432
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26605866
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.22870139
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17227319
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.15997591
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11416889
30* RNF2_27304074_Chip-Seq_NSC_Mouse2.07786522
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.06374965
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05177472
33DCP1A_22483619_ChIP-Seq_HELA_Human2.04076497
34CBX2_27304074_Chip-Seq_ESCs_Mouse2.01953160
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01233691
36GATA1_19941826_ChIP-Seq_K562_Human2.00199154
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.98601115
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98196077
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93664042
40TAL1_26923725_Chip-Seq_HPCs_Mouse1.91725134
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.91539347
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90008997
43TTF2_22483619_ChIP-Seq_HELA_Human1.89785090
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.88183287
45VDR_22108803_ChIP-Seq_LS180_Human1.86662347
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84686140
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84584992
48ZNF263_19887448_ChIP-Seq_K562_Human1.82115906
49CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80243363
50* STAT1_17558387_ChIP-Seq_HELA_Human1.77879859
51GATA3_21867929_ChIP-Seq_TH1_Mouse1.75673036
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.71534355
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71097079
54KDM5A_27292631_Chip-Seq_BREAST_Human1.70549886
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70191813
56GABP_19822575_ChIP-Seq_HepG2_Human1.68369770
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66782017
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62992663
59RUNX1_26923725_Chip-Seq_HPCs_Mouse1.62452985
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.62118001
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61618569
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61483036
63HTT_18923047_ChIP-ChIP_STHdh_Human1.61284368
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58416915
65AR_21909140_ChIP-Seq_LNCAP_Human1.58412713
66* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.57164076
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57080647
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56531915
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55197634
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54994569
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54662897
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53986997
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53763537
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52898833
75ZNF274_21170338_ChIP-Seq_K562_Hela1.52029851
76MYC_22102868_ChIP-Seq_BL_Human1.51605602
77GATA1_22025678_ChIP-Seq_K562_Human1.51421167
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48895243
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.48721033
80GATA3_21867929_ChIP-Seq_CD8_Mouse1.48158909
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47824197
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47278560
83GF1_26923725_Chip-Seq_HPCs_Mouse1.47046890
84FOXP3_21729870_ChIP-Seq_TREG_Human1.46431795
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46166515
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42676231
87GATA2_19941826_ChIP-Seq_K562_Human1.40840637
88TAF15_26573619_Chip-Seq_HEK293_Human1.40604670
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.39688855
90CIITA_25753668_ChIP-Seq_RAJI_Human1.39608701
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34724544
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34549500
93ELK1_19687146_ChIP-ChIP_HELA_Human1.34425697
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34109457
95VDR_23849224_ChIP-Seq_CD4+_Human1.33311724
96SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.32269238
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31617878
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30574039
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30213697
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29845351
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29694700
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29667198
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29089960
104KDM2B_26808549_Chip-Seq_REH_Human1.28864818
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28640639
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28640639
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28165418
108REST_21632747_ChIP-Seq_MESCs_Mouse1.26602506
109P53_22387025_ChIP-Seq_ESCs_Mouse1.26066176
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25867167
111TFEB_21752829_ChIP-Seq_HELA_Human1.25857482
112FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25708201
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.25319474
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.24692870
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24654955
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24411289
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24135725
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23283869
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23089928
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.22923751
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22631969
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.22256862
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.21142613
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20357215
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19657973
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19457339
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19247760
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.17156309
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16177021
130KLF4_18555785_Chip-Seq_ESCs_Mouse1.15698197
131P300_18555785_Chip-Seq_ESCs_Mouse1.15459178
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.15164184
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.14266310
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12954231
135GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12451379
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12447917
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10590730
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10226724
139FUS_26573619_Chip-Seq_HEK293_Human1.09939309
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09892242
141ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09749463
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09608681
143FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09200884
144SPI1_26923725_Chip-Seq_HPCs_Mouse1.08816484
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.08688032
146WDR5_24793694_ChIP-Seq_LNCAP_Human1.08074058
147RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07493699
148CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07004207
149NFYB_21822215_ChIP-Seq_K562_Human1.06826297
150SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06625674
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06032495
152NMYC_18555785_Chip-Seq_ESCs_Mouse1.05913906
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05212293
154PU1_27457419_Chip-Seq_LIVER_Mouse1.05019122
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04930150
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04820358
157E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02757335
158P53_21459846_ChIP-Seq_SAOS-2_Human1.02512492
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02025913
160CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01870909
161* SPI1_23127762_ChIP-Seq_K562_Human1.01795035
162PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01514664
163TCF4_23295773_ChIP-Seq_U87_Human1.01505093
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01121492
165GF1B_26923725_Chip-Seq_HPCs_Mouse1.00840608
166FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00386801
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.99778673
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99736697
169SCL_19346495_ChIP-Seq_HPC-7_Human0.99357621
170SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98396102
171CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98196470
172SMAD4_21741376_ChIP-Seq_EPCs_Human0.98115960
173OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97771732
174CBP_20019798_ChIP-Seq_JUKART_Human0.97586126
175IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97586126
176LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.96970514
177ZFX_18555785_Chip-Seq_ESCs_Mouse0.96803909
178TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96724158
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96037769
180SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95652280
181CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94429991
182CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94288755
183CHD1_26751641_Chip-Seq_LNCaP_Human0.93655316
184E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91153919
185NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89913167
186HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89443786
187* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88901218
188VDR_21846776_ChIP-Seq_THP-1_Human0.87700651
189CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87088675
190GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82716520
191HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81072092
192DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79226068
193KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78524218
194TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.77641417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.31445588
2MP0008995_early_reproductive_senescence5.82489176
3MP0003698_abnormal_male_reproductive5.58634680
4MP0001929_abnormal_gametogenesis5.53872662
5MP0002210_abnormal_sex_determination4.71477015
6MP0005171_absent_coat_pigmentation4.65816698
7MP0004147_increased_porphyrin_level4.25838579
8MP0001145_abnormal_male_reproductive3.74587909
9MP0000653_abnormal_sex_gland3.26245066
10MP0002161_abnormal_fertility/fecundity3.11172417
11MP0005408_hypopigmentation3.03380169
12MP0003786_premature_aging3.02874289
13MP0000678_abnormal_parathyroid_gland2.86245450
14MP0005670_abnormal_white_adipose2.41168133
15MP0009697_abnormal_copulation2.27561777
16MP0010094_abnormal_chromosome_stability2.25703803
17MP0008058_abnormal_DNA_repair2.21525854
18MP0003656_abnormal_erythrocyte_physiolo2.18838034
19MP0002877_abnormal_melanocyte_morpholog2.18781911
20MP0005410_abnormal_fertilization11.5069640
21MP0001984_abnormal_olfaction1.82704292
22MP0005083_abnormal_biliary_tract1.80105233
23MP0001545_abnormal_hematopoietic_system1.78801606
24MP0005397_hematopoietic_system_phenotyp1.78801606
25MP0002132_abnormal_respiratory_system1.70555468
26MP0002095_abnormal_skin_pigmentation1.67228351
27MP0000350_abnormal_cell_proliferation1.65383400
28MP0000015_abnormal_ear_pigmentation1.58037492
29MP0002396_abnormal_hematopoietic_system1.57914956
30MP0001697_abnormal_embryo_size1.57591384
31MP0006036_abnormal_mitochondrial_physio1.50009816
32MP0003111_abnormal_nucleus_morphology1.45486701
33MP0002080_prenatal_lethality1.42865736
34MP0001672_abnormal_embryogenesis/_devel1.42038154
35MP0005380_embryogenesis_phenotype1.42038154
36MP0006035_abnormal_mitochondrial_morpho1.40578324
37MP0001661_extended_life_span1.38914125
38MP0003984_embryonic_growth_retardation1.31617138
39MP0004233_abnormal_muscle_weight1.30711980
40MP0002653_abnormal_ependyma_morphology1.29462921
41MP0005623_abnormal_meninges_morphology1.27742298
42MP0003186_abnormal_redox_activity1.26281198
43MP0008007_abnormal_cellular_replicative1.25753354
44MP0005075_abnormal_melanosome_morpholog1.25730528
45MP0002088_abnormal_embryonic_growth/wei1.25560327
46MP0000371_diluted_coat_color1.24304571
47MP0008057_abnormal_DNA_replication1.23691557
48MP0005058_abnormal_lysosome_morphology1.22136341
49MP0004145_abnormal_muscle_electrophysio1.21205670
50MP0009278_abnormal_bone_marrow1.20217730
51MP0002086_abnormal_extraembryonic_tissu1.17412867
52MP0003385_abnormal_body_wall1.12638686
53MP0008438_abnormal_cutaneous_collagen1.12562296
54MP0000358_abnormal_cell_content/1.12380350
55MP0001119_abnormal_female_reproductive1.09222896
56MP0003136_yellow_coat_color1.07596316
57MP0002938_white_spotting1.05665267
58MP0005377_hearing/vestibular/ear_phenot1.05011048
59MP0003878_abnormal_ear_physiology1.05011048
60MP0003806_abnormal_nucleotide_metabolis1.03906771
61MP0002249_abnormal_larynx_morphology1.01643911
62MP0002075_abnormal_coat/hair_pigmentati1.01571522
63MP0002085_abnormal_embryonic_tissue0.97897497
64MP0002084_abnormal_developmental_patter0.97649021
65MP0002160_abnormal_reproductive_system0.96680719
66MP0003705_abnormal_hypodermis_morpholog0.96494956
67MP0003567_abnormal_fetal_cardiomyocyte0.93534350
68MP0005451_abnormal_body_composition0.93450960
69MP0003077_abnormal_cell_cycle0.93143670
70MP0004381_abnormal_hair_follicle0.92466365
71MP0003123_paternal_imprinting0.92053605
72MP0003959_abnormal_lean_body0.92030984
73MP0005551_abnormal_eye_electrophysiolog0.91748389
74MP0003699_abnormal_female_reproductive0.91053041
75MP0001186_pigmentation_phenotype0.90572945
76MP0002019_abnormal_tumor_incidence0.87538535
77MP0005636_abnormal_mineral_homeostasis0.83013321
78MP0008775_abnormal_heart_ventricle0.82497122
79MP0008770_decreased_survivor_rate0.81657653
80MP0009046_muscle_twitch0.79960038
81MP0005174_abnormal_tail_pigmentation0.75936692
82MP0005076_abnormal_cell_differentiation0.75421866
83MP0004742_abnormal_vestibular_system0.74031129
84MP0003221_abnormal_cardiomyocyte_apopto0.73369276
85MP0003787_abnormal_imprinting0.72336236
86MP0000703_abnormal_thymus_morphology0.71782536
87MP0001502_abnormal_circadian_rhythm0.70305470
88MP0004197_abnormal_fetal_growth/weight/0.67752699
89MP0001727_abnormal_embryo_implantation0.67418091
90MP0000681_abnormal_thyroid_gland0.67299589
91MP0005253_abnormal_eye_physiology0.67220231
92MP0003315_abnormal_perineum_morphology0.64885499
93MP0003942_abnormal_urinary_system0.64364196
94MP0009672_abnormal_birth_weight0.62878593
95MP0005647_abnormal_sex_gland0.62620339
96MP0005384_cellular_phenotype0.62061971
97MP0001873_stomach_inflammation0.61824519
98MP0004808_abnormal_hematopoietic_stem0.61515882
99MP0010630_abnormal_cardiac_muscle0.61263353
100MP0004019_abnormal_vitamin_homeostasis0.59328587
101MP0001293_anophthalmia0.59205747
102MP0003693_abnormal_embryo_hatching0.58565998
103MP0003646_muscle_fatigue0.56829756
104MP0000609_abnormal_liver_physiology0.56652917
105MP0009931_abnormal_skin_appearance0.56008038
106MP0001881_abnormal_mammary_gland0.55405839
107MP0009703_decreased_birth_body0.54989494
108MP0008260_abnormal_autophagy0.54498435
109MP0000747_muscle_weakness0.53813418
110MP0001765_abnormal_ion_homeostasis0.53722828
111MP0000647_abnormal_sebaceous_gland0.53231177
112MP0008932_abnormal_embryonic_tissue0.52700003
113MP0002282_abnormal_trachea_morphology0.49209350
114MP0000383_abnormal_hair_follicle0.47741410
115MP0006072_abnormal_retinal_apoptosis0.47338730
116MP0002090_abnormal_vision0.44898160
117MP0009115_abnormal_fat_cell0.44736573
118MP0002735_abnormal_chemical_nociception0.44619321
119MP0001835_abnormal_antigen_presentation0.43633185
120MP0000537_abnormal_urethra_morphology0.42696811
121MP0001730_embryonic_growth_arrest0.42043702
122MP0004036_abnormal_muscle_relaxation0.41128443
123MP0002139_abnormal_hepatobiliary_system0.40139442
124MP0005391_vision/eye_phenotype0.40099955
125MP0002184_abnormal_innervation0.38029501
126MP0002697_abnormal_eye_size0.36758591
127MP0002233_abnormal_nose_morphology0.36636811
128MP0003632_abnormal_nervous_system0.36614315
129MP0002736_abnormal_nociception_after0.35452974
130MP0002234_abnormal_pharynx_morphology0.35261233
131MP0003011_delayed_dark_adaptation0.34897353
132MP0003941_abnormal_skin_development0.34379236
133MP0003045_fibrosis0.33276879
134MP0005165_increased_susceptibility_to0.32848828
135MP0004811_abnormal_neuron_physiology0.32644831
136MP0003252_abnormal_bile_duct0.32619020
137MP0002089_abnormal_postnatal_growth/wei0.32555044
138MP0000313_abnormal_cell_death0.30911921
139MP0004782_abnormal_surfactant_physiolog0.30713130
140MP0003121_genomic_imprinting0.30355175
141MP0003718_maternal_effect0.30245148
142MP0002638_abnormal_pupillary_reflex0.30115058
143MP0001968_abnormal_touch/_nociception0.29778917
144MP0000579_abnormal_nail_morphology0.29459443
145MP0005389_reproductive_system_phenotype0.29437989
146MP0001529_abnormal_vocalization0.29406828
147MP0001485_abnormal_pinna_reflex0.29330449
148MP0003115_abnormal_respiratory_system0.28577699
149MP0002009_preneoplasia0.28471973
150MP0003879_abnormal_hair_cell0.28135635
151MP0005167_abnormal_blood-brain_barrier0.27943087
152MP0005666_abnormal_adipose_tissue0.26519030
153MP0003861_abnormal_nervous_system0.26200153
154MP0000372_irregular_coat_pigmentation0.25509839
155MP0003075_altered_response_to0.25287436
156MP0003631_nervous_system_phenotype0.24490985
157MP0004957_abnormal_blastocyst_morpholog0.24390365
158MP0000427_abnormal_hair_cycle0.24285598
159MP0010307_abnormal_tumor_latency0.23233255
160MP0002928_abnormal_bile_duct0.22657605
161MP0009764_decreased_sensitivity_to0.22558770
162MP0003890_abnormal_embryonic-extraembry0.22304609
163MP0004133_heterotaxia0.21830166
164MP0002152_abnormal_brain_morphology0.21814350
165MP0010678_abnormal_skin_adnexa0.21445521
166MP0002229_neurodegeneration0.20980730
167MP0004510_myositis0.20905911
168MP0002269_muscular_atrophy0.20853137

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.65708760
2Abnormal respiratory motile cilium morphology (HP:0005938)7.61249015
3Abnormal respiratory epithelium morphology (HP:0012253)7.61249015
4Rhinitis (HP:0012384)6.91716709
5Chronic bronchitis (HP:0004469)6.69763277
6Abnormal ciliary motility (HP:0012262)6.63534052
7Abnormal spermatogenesis (HP:0008669)6.28450891
8Azoospermia (HP:0000027)6.25755226
9Truncus arteriosus (HP:0001660)6.16084249
10Infertility (HP:0000789)5.63592986
11Hyperthyroidism (HP:0000836)5.57274643
12Reticulocytosis (HP:0001923)5.52577114
13Nasal polyposis (HP:0100582)5.04407847
14Abnormality of reticulocytes (HP:0004312)4.66848603
15Polycythemia (HP:0001901)4.30129269
16Bronchiectasis (HP:0002110)4.11727223
17Bowel incontinence (HP:0002607)4.08522043
18Abnormality of the nasal mucosa (HP:0000433)4.02177371
19Hypertensive crisis (HP:0100735)3.94228318
20Abnormal large intestine physiology (HP:0012700)3.90822062
21Ankyloglossia (HP:0010296)3.89876318
22Bronchitis (HP:0012387)3.86159929
23Facial cleft (HP:0002006)3.75970014
24Seborrheic dermatitis (HP:0001051)3.74511841
25Abnormality of the heme biosynthetic pathway (HP:0010472)3.73054012
26Birth length less than 3rd percentile (HP:0003561)3.72416404
27Abnormality of glycolysis (HP:0004366)3.60091404
28Abnormality of homocysteine metabolism (HP:0010919)3.59346699
29Homocystinuria (HP:0002156)3.59346699
30Nephronophthisis (HP:0000090)3.54447090
31Peripheral hypomyelination (HP:0007182)3.49632291
32Abnormality of the tricuspid valve (HP:0001702)3.45927218
33Atelectasis (HP:0100750)3.37842918
34Hypoparathyroidism (HP:0000829)3.33721258
35Cholelithiasis (HP:0001081)3.33254117
36Male infertility (HP:0003251)3.33161857
37Ileus (HP:0002595)3.32774450
38Upper limb muscle weakness (HP:0003484)3.31974069
39Increased serum pyruvate (HP:0003542)3.25247277
40Abnormal hemoglobin (HP:0011902)3.15907503
41Cortical dysplasia (HP:0002539)3.11167595
42Abnormality of the lower motor neuron (HP:0002366)3.05988023
43Gonadotropin excess (HP:0000837)3.02105021
44Impulsivity (HP:0100710)3.01702863
45Abnormality of cochlea (HP:0000375)3.00872170
46Pallor (HP:0000980)2.97049363
47Morphological abnormality of the inner ear (HP:0011390)2.93139964
48Poikilocytosis (HP:0004447)2.92438254
49Abnormal gallbladder morphology (HP:0012437)2.91802794
50Recurrent sinusitis (HP:0011108)2.89734300
51Reticulocytopenia (HP:0001896)2.85866190
52Absent eyebrow (HP:0002223)2.82165317
53White forelock (HP:0002211)2.81801846
54Recurrent otitis media (HP:0000403)2.76681301
55Acute myeloid leukemia (HP:0004808)2.75580148
56Abnormality of the renal medulla (HP:0100957)2.74520188
57Abnormality of oral frenula (HP:0000190)2.72065026
58Aplasia/Hypoplasia of the earlobes (HP:0009906)2.65924466
59Aplasia/Hypoplasia of the macula (HP:0008059)2.64785864
60Patchy hypopigmentation of hair (HP:0011365)2.64732106
61Median cleft lip (HP:0000161)2.63203743
62Short middle phalanx of the 5th finger (HP:0004220)2.62491793
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.58482369
64Hypoplasia of the fovea (HP:0007750)2.58482369
65Increased nuchal translucency (HP:0010880)2.52821571
66Orthostatic hypotension (HP:0001278)2.52654324
67Aplasia/Hypoplasia affecting the retina (HP:0008061)2.52188913
68Tubulointerstitial nephritis (HP:0001970)2.50118091
69Abnormality of the gallbladder (HP:0005264)2.49972843
70Abnormally folded helix (HP:0008544)2.48639328
71Overlapping toe (HP:0001845)2.47116137
72Acanthocytosis (HP:0001927)2.47090212
73Fibular hypoplasia (HP:0003038)2.43861594
74Cleft eyelid (HP:0000625)2.38286043
75Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37307120
76Postaxial foot polydactyly (HP:0001830)2.32932386
77Breech presentation (HP:0001623)2.32767117
78Myelodysplasia (HP:0002863)2.31951769
79Chromsome breakage (HP:0040012)2.29229806
80Insomnia (HP:0100785)2.27889790
81Patellar dislocation (HP:0002999)2.26374863
82Hyperbilirubinemia (HP:0002904)2.25924432
83Disproportionate tall stature (HP:0001519)2.24709829
84Aplasia/Hypoplasia of the thymus (HP:0010515)2.20596417
85Flat cornea (HP:0007720)2.19719449
86Congenital stationary night blindness (HP:0007642)2.19342786
87Abnormality of DNA repair (HP:0003254)2.13451230
88Molar tooth sign on MRI (HP:0002419)2.12088726
89Abnormality of midbrain morphology (HP:0002418)2.12088726
90Tubulointerstitial abnormality (HP:0001969)2.11930030
91Severe visual impairment (HP:0001141)2.11707728
92Sandal gap (HP:0001852)2.10764646
93Nonimmune hydrops fetalis (HP:0001790)2.07188839
94Cheekbone underdevelopment (HP:0010669)2.06749100
95Abnormality of sulfur amino acid metabolism (HP:0004339)2.06503065
96Cerebral hypomyelination (HP:0006808)2.03728805
97Abnormality of the fovea (HP:0000493)2.01263737
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6039700
99Dynein arm defect of respiratory motile cilia (HP:0012255)10.6595599
100Absent/shortened dynein arms (HP:0200106)10.6595599
101Attention deficit hyperactivity disorder (HP:0007018)1.99837712
102Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.98627132
103Recurrent bronchitis (HP:0002837)1.97091030
104Overfolded helix (HP:0000396)1.97067551
105Medial flaring of the eyebrow (HP:0010747)1.94037732
106Cafe-au-lait spot (HP:0000957)1.91279455
107Decreased central vision (HP:0007663)1.91167630
108Premature ovarian failure (HP:0008209)1.91158819
109Congenital hepatic fibrosis (HP:0002612)1.90687714
110Venous insufficiency (HP:0005293)1.88074849
111Tubular atrophy (HP:0000092)1.88035934
112Abnormality of cells of the erythroid lineage (HP:0012130)1.87753654
113Amyotrophic lateral sclerosis (HP:0007354)1.87214469
114Obsessive-compulsive behavior (HP:0000722)1.86464428
115Heterotopia (HP:0002282)1.86198148
116Abnormal number of erythroid precursors (HP:0012131)1.82676861
117Spastic paraparesis (HP:0002313)1.80483757
118Cholecystitis (HP:0001082)1.79711631
119Abnormal gallbladder physiology (HP:0012438)1.79711631
120Cutaneous melanoma (HP:0012056)1.79331178
121Postaxial hand polydactyly (HP:0001162)1.76865552
122Angiofibromas (HP:0010615)1.76417632
123Adenoma sebaceum (HP:0009720)1.76417632
124Duplicated collecting system (HP:0000081)1.75635570
125Mesomelia (HP:0003027)1.75363770
126Tinnitus (HP:0000360)1.74809514
127Urethral obstruction (HP:0000796)1.71878655
128Secondary amenorrhea (HP:0000869)1.71666883
129Acute encephalopathy (HP:0006846)1.71611255
130Hand muscle atrophy (HP:0009130)1.71311223
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.70291582
132Septate vagina (HP:0001153)1.69968915
133Redundant skin (HP:0001582)1.69091506
134Macrocytic anemia (HP:0001972)1.68628526
135Esophageal neoplasm (HP:0100751)1.68155707
136Neoplasm of head and neck (HP:0012288)1.68155707
137Abnormality of the carotid arteries (HP:0005344)1.68035147
138Relative macrocephaly (HP:0004482)1.67923043
139Shoulder girdle muscle weakness (HP:0003547)1.67743028
140Breast hypoplasia (HP:0003187)1.66758420
141Tubulointerstitial fibrosis (HP:0005576)1.64609403
142Abnormal mitochondria in muscle tissue (HP:0008316)1.64227696
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.62714816
144Dysmetric saccades (HP:0000641)1.62076259
145Meckel diverticulum (HP:0002245)1.60531476
146Venous abnormality (HP:0002624)1.60004245
147Ocular albinism (HP:0001107)1.59545328
148Abnormality of the preputium (HP:0100587)1.59241392
149Spastic tetraparesis (HP:0001285)1.58885862
150Insidious onset (HP:0003587)1.58770189
151Termporal pattern (HP:0011008)1.58770189
152Fatigue (HP:0012378)1.58013773
153Upper motor neuron abnormality (HP:0002127)1.57426008
154Abnormality of the renal cortex (HP:0011035)1.57181409
155Microglossia (HP:0000171)1.57114005
156Ectopic kidney (HP:0000086)1.55784727
157Absent thumb (HP:0009777)1.54849544
158Abnormality of chromosome stability (HP:0003220)1.54012111
159Stage 5 chronic kidney disease (HP:0003774)1.51863343
160Small intestinal stenosis (HP:0012848)1.51484552
161Duodenal stenosis (HP:0100867)1.51484552
162Short ribs (HP:0000773)1.49908540
163Short tibia (HP:0005736)1.47792369
164Hemorrhage of the eye (HP:0011885)1.46601543
165Abnormality of the ileum (HP:0001549)1.46131009
166Bony spicule pigmentary retinopathy (HP:0007737)1.38856171
167Abnormality of macular pigmentation (HP:0008002)1.38527872
168Short thorax (HP:0010306)1.37380975
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.36400215
170Abnormality of the renal collecting system (HP:0004742)1.34907479
171Ventricular fibrillation (HP:0001663)1.33929603
172Hypopigmentation of the fundus (HP:0007894)1.32885064
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.31870658
174Subcapsular cataract (HP:0000523)1.31179682
175Broad palm (HP:0001169)1.30179353
176Bell-shaped thorax (HP:0001591)1.29126602
177Central scotoma (HP:0000603)1.28299324
178Neurofibrillary tangles (HP:0002185)1.27433748
179Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24845067
180Difficulty climbing stairs (HP:0003551)1.24188833
181Pelvic girdle muscle weakness (HP:0003749)1.24016613
182Renal dysplasia (HP:0000110)1.23776159
183Choroideremia (HP:0001139)1.22705869
184Abnormality of the sella turcica (HP:0002679)1.21417422
185Abnormality of ocular smooth pursuit (HP:0000617)1.20932219
186Impaired proprioception (HP:0010831)1.19943326
187Oculomotor apraxia (HP:0000657)1.19165319
188Aplasia/Hypoplasia of the tongue (HP:0010295)1.18607601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.07837212
2PDK48.07837212
3PDK25.03560593
4EIF2AK14.21386124
5TESK14.19895642
6KSR23.54936471
7ICK3.38009849
8PRKD33.24200055
9EEF2K2.96831113
10MAP3K22.82110185
11CDC72.47431809
12NEK22.36048062
13RAF12.34116173
14PTK2B2.11344615
15RIPK41.95399785
16TSSK61.89399868
17KSR11.84634320
18SRPK11.81957480
19CDK121.77614315
20STK391.73065146
21PBK1.68649961
22ACVR1B1.62952066
23NME11.60792179
24MAP3K81.52766275
25STK381.52077435
26IRAK31.44241869
27WNK41.41897901
28STK38L1.35900917
29RPS6KA41.34688194
30TTK1.32250169
31BMX1.29409768
32NME21.28562796
33MAP3K41.27692585
34PDK11.23658342
35TRIB31.18326918
36RPS6KB21.14527699
37SCYL21.14276050
38DYRK1B1.03515044
39ATR1.02018601
40STK161.01448185
41RET0.93507769
42ALK0.92369227
43CLK10.90338362
44BUB10.89245328
45PLK10.83363443
46EIF2AK30.79168257
47TRPM70.78617930
48CHEK20.77779759
49PDPK10.77010713
50IRAK10.75234966
51MARK30.73833505
52MTOR0.73591904
53CHEK10.73122523
54JAK20.72973811
55WEE10.72439764
56MKNK10.67978655
57MAP2K10.67803363
58TBK10.67606124
59ATM0.67560812
60PNCK0.67203833
61CDK70.66437294
62PINK10.65234525
63MAPKAPK50.65010962
64MAP3K10.63041614
65WNK10.62770889
66PTK60.62694832
67NTRK10.60345017
68PASK0.57197244
69STK30.55969718
70CDK40.55198179
71TYRO30.54201045
72BRD40.54064621
73CSNK2A20.54034798
74PIK3CG0.53794743
75NEK10.52231389
76CSNK1E0.50679707
77STK40.49990439
78AKT30.48136712
79BRSK10.47881192
80CDK30.47698418
81PLK40.47326439
82MAPK100.47266733
83BCR0.47243635
84PAK20.47194533
85FGFR40.47097768
86DYRK30.45478436
87LRRK20.44559549
88JAK30.43879126
89ILK0.43416828
90MAP3K60.42402401
91MUSK0.42103832
92CDK90.41487385
93MATK0.40862514
94PKN20.40479375
95MAPK110.40377903
96MAP2K60.40280178
97CSF1R0.39990794
98PRPF4B0.38749216
99MAPK140.37736243
100LATS20.36700789
101YES10.35676279
102AKT20.35533990
103CAMK1G0.34489232
104PRKCG0.34001375
105PHKG20.33372702
106PHKG10.33372702
107CCNB10.32873146
108AURKB0.32642493
109PLK20.31648493
110STK110.31360727
111AKT10.31157433
112MAPKAPK30.30775070
113BRSK20.30480488
114CDK150.29383410
115MST40.28550884
116MAPK30.28158142
117CDK180.26123262
118EIF2AK20.26030173
119CDK140.25449162
120CDK10.23963969
121MAPK150.23624599
122CAMKK10.22522114
123WNK30.21728617
124IRAK20.21437402
125CDK20.20651728
126GSK3B0.20504365
127CDK11A0.20255510
128CSNK2A10.20243629
129LMTK20.18289431
130BMPR20.17817163
131PAK10.17365191
132STK100.17185785
133CAMK1D0.17039355
134NEK60.16560942
135PRKAA10.16205196
136PLK30.15915941
137CSNK1D0.14282227
138AURKA0.12595864
139BLK0.11562300
140NTRK30.11432475
141VRK10.10491672
142PRKDC0.09541556
143DAPK20.09441668
144BRAF0.09394315
145PRKCD0.08471707
146MAPK80.08403790
147MAP3K90.08056080
148MET0.08006322
149RPS6KA10.07586092
150PRKCZ0.07189494
151GRK50.06928202
152DYRK1A0.06839937

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.60419435
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.34317778
3Fatty acid biosynthesis_Homo sapiens_hsa000613.07360325
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75755097
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.72357492
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52826350
7Pyruvate metabolism_Homo sapiens_hsa006202.46805220
8Vitamin B6 metabolism_Homo sapiens_hsa007502.42991219
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39943440
10Fanconi anemia pathway_Homo sapiens_hsa034602.38002822
11Non-homologous end-joining_Homo sapiens_hsa034502.36866688
12Selenocompound metabolism_Homo sapiens_hsa004502.34924461
13Linoleic acid metabolism_Homo sapiens_hsa005912.32255005
14Propanoate metabolism_Homo sapiens_hsa006402.29405325
15Pentose phosphate pathway_Homo sapiens_hsa000302.28640838
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.20207188
17Glucagon signaling pathway_Homo sapiens_hsa049222.18459529
18Nucleotide excision repair_Homo sapiens_hsa034202.12529030
19Ribosome_Homo sapiens_hsa030102.11665115
20Oocyte meiosis_Homo sapiens_hsa041142.11167346
21Dorso-ventral axis formation_Homo sapiens_hsa043202.01122081
22Proteasome_Homo sapiens_hsa030502.00436193
23Glycerolipid metabolism_Homo sapiens_hsa005611.90930071
24Base excision repair_Homo sapiens_hsa034101.82662237
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.79100933
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76313830
27RNA transport_Homo sapiens_hsa030131.70244303
28mRNA surveillance pathway_Homo sapiens_hsa030151.70194627
29Steroid biosynthesis_Homo sapiens_hsa001001.66418026
30Olfactory transduction_Homo sapiens_hsa047401.47906740
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42948579
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41584210
33Homologous recombination_Homo sapiens_hsa034401.39946910
34Acute myeloid leukemia_Homo sapiens_hsa052211.35045468
35Mineral absorption_Homo sapiens_hsa049781.34998404
36Purine metabolism_Homo sapiens_hsa002301.34140681
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.31198473
38Cell cycle_Homo sapiens_hsa041101.30257695
39RNA polymerase_Homo sapiens_hsa030201.28104274
40Collecting duct acid secretion_Homo sapiens_hsa049661.25603968
41Thyroid cancer_Homo sapiens_hsa052161.24229775
42Herpes simplex infection_Homo sapiens_hsa051681.24097572
43Chronic myeloid leukemia_Homo sapiens_hsa052201.23380829
44Ether lipid metabolism_Homo sapiens_hsa005651.20820657
45PPAR signaling pathway_Homo sapiens_hsa033201.20764815
46Renin secretion_Homo sapiens_hsa049241.15370380
47ABC transporters_Homo sapiens_hsa020101.07723358
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05590361
49Synaptic vesicle cycle_Homo sapiens_hsa047211.05501594
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.01337495
51Carbon metabolism_Homo sapiens_hsa012001.00630181
52DNA replication_Homo sapiens_hsa030300.99545711
53Parkinsons disease_Homo sapiens_hsa050120.99005309
54Cardiac muscle contraction_Homo sapiens_hsa042600.95145190
55Huntingtons disease_Homo sapiens_hsa050160.93017657
56Influenza A_Homo sapiens_hsa051640.92247727
57Other glycan degradation_Homo sapiens_hsa005110.91735193
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90047759
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89678056
60Fatty acid metabolism_Homo sapiens_hsa012120.89528535
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88365638
62Non-small cell lung cancer_Homo sapiens_hsa052230.86485003
63mTOR signaling pathway_Homo sapiens_hsa041500.86305351
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.85534149
65ErbB signaling pathway_Homo sapiens_hsa040120.84319304
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80173197
67Fructose and mannose metabolism_Homo sapiens_hsa000510.79356025
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79005310
69Insulin secretion_Homo sapiens_hsa049110.78092667
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77194067
71Oxidative phosphorylation_Homo sapiens_hsa001900.77186717
72HIF-1 signaling pathway_Homo sapiens_hsa040660.75454323
73Amphetamine addiction_Homo sapiens_hsa050310.75077211
74Arginine biosynthesis_Homo sapiens_hsa002200.73518412
75N-Glycan biosynthesis_Homo sapiens_hsa005100.73359159
76One carbon pool by folate_Homo sapiens_hsa006700.71766692
77Calcium signaling pathway_Homo sapiens_hsa040200.71577780
78Pancreatic cancer_Homo sapiens_hsa052120.70838400
79Fatty acid degradation_Homo sapiens_hsa000710.70815953
80Type II diabetes mellitus_Homo sapiens_hsa049300.70738004
81Staphylococcus aureus infection_Homo sapiens_hsa051500.70134326
82Antigen processing and presentation_Homo sapiens_hsa046120.70013130
83Biosynthesis of amino acids_Homo sapiens_hsa012300.69218859
84Renal cell carcinoma_Homo sapiens_hsa052110.68911017
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68178686
86Morphine addiction_Homo sapiens_hsa050320.67077766
87Tyrosine metabolism_Homo sapiens_hsa003500.66223317
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65357602
89Pyrimidine metabolism_Homo sapiens_hsa002400.64443858
90Sulfur relay system_Homo sapiens_hsa041220.64258920
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63180511
92Lysine degradation_Homo sapiens_hsa003100.62005017
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.60808982
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.59942935
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59798379
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59149816
97RNA degradation_Homo sapiens_hsa030180.57594695
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56282752
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.54991453
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54603697
101Insulin signaling pathway_Homo sapiens_hsa049100.54502497
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54220866
103Fat digestion and absorption_Homo sapiens_hsa049750.52888996
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52817711
105Bile secretion_Homo sapiens_hsa049760.52045737
106Prion diseases_Homo sapiens_hsa050200.51896416
107MicroRNAs in cancer_Homo sapiens_hsa052060.51639450
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50592514
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50526454
110Circadian entrainment_Homo sapiens_hsa047130.49923646
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48577171
112Estrogen signaling pathway_Homo sapiens_hsa049150.48268679
113Glioma_Homo sapiens_hsa052140.48261577
114Mismatch repair_Homo sapiens_hsa034300.46119247
115Epstein-Barr virus infection_Homo sapiens_hsa051690.45369078
116Prolactin signaling pathway_Homo sapiens_hsa049170.44039042
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43896558
118Arachidonic acid metabolism_Homo sapiens_hsa005900.43041832
119Legionellosis_Homo sapiens_hsa051340.42811351
120Salmonella infection_Homo sapiens_hsa051320.42668184
121cAMP signaling pathway_Homo sapiens_hsa040240.42591380
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41121857
123Alzheimers disease_Homo sapiens_hsa050100.40397852
124Long-term potentiation_Homo sapiens_hsa047200.39470893
125Nicotine addiction_Homo sapiens_hsa050330.39234885
126Fatty acid elongation_Homo sapiens_hsa000620.38342298
127Viral carcinogenesis_Homo sapiens_hsa052030.37570353
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36763334
129Glutathione metabolism_Homo sapiens_hsa004800.33826625
130Bladder cancer_Homo sapiens_hsa052190.33761098
131Salivary secretion_Homo sapiens_hsa049700.33475290
132Hepatitis B_Homo sapiens_hsa051610.33035082
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32911023
134Spliceosome_Homo sapiens_hsa030400.31918326
135Butanoate metabolism_Homo sapiens_hsa006500.31399855
136VEGF signaling pathway_Homo sapiens_hsa043700.29383263
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.29312086
138Galactose metabolism_Homo sapiens_hsa000520.28674632
139Pancreatic secretion_Homo sapiens_hsa049720.28126161
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28117525
141p53 signaling pathway_Homo sapiens_hsa041150.27711882
142Metabolic pathways_Homo sapiens_hsa011000.27662472
143Endometrial cancer_Homo sapiens_hsa052130.26114248
144Colorectal cancer_Homo sapiens_hsa052100.25790665
145Taste transduction_Homo sapiens_hsa047420.25506301
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25279113
147Inositol phosphate metabolism_Homo sapiens_hsa005620.25066396
148HTLV-I infection_Homo sapiens_hsa051660.24966188
149Rheumatoid arthritis_Homo sapiens_hsa053230.24290525
150Protein export_Homo sapiens_hsa030600.24211093
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.22657934
152Shigellosis_Homo sapiens_hsa051310.22470699
153Prostate cancer_Homo sapiens_hsa052150.22459201
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22253898
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22189198
156Chemical carcinogenesis_Homo sapiens_hsa052040.21617110

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