ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	6.32695042
2	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.22177318
3	male meiosis I (GO:0007141)	5.11754869
4	* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	43.1955130
5	multicellular organism reproduction (GO:0032504)	4.98315681
6	regulation of female gonad development (GO:2000194)	4.89843318
7	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.67370792
8	meiosis I (GO:0007127)	4.42983450
9	regulation of female receptivity (GO:0045924)	4.16354982
10	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.05675767
11	regulation of uterine smooth muscle contraction (GO:0070472)	4.04336066
12	* regulation of retinoic acid receptor signaling pathway (GO:0048385)	35.9011270
13	protein kinase C signaling (GO:0070528)	3.99068206
14	aggressive behavior (GO:0002118)	3.98620379
15	regulation of DNA methylation (GO:0044030)	3.97461765
16	drinking behavior (GO:0042756)	3.93822300
17	positive regulation of humoral immune response (GO:0002922)	3.84340287
18	regulation of penile erection (GO:0060405)	3.78360713
19	positive regulation of prostaglandin secretion (GO:0032308)	3.67799729
20	hyperosmotic salinity response (GO:0042538)	3.67115461
21	female mating behavior (GO:0060180)	3.59221830
22	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.49549714
23	mitotic chromosome condensation (GO:0007076)	3.46923398
24	sleep (GO:0030431)	3.41251268
25	oocyte development (GO:0048599)	3.40721938
26	negative regulation of reproductive process (GO:2000242)	3.38881846
27	positive regulation of digestive system process (GO:0060456)	3.37949715
28	response to acidic pH (GO:0010447)	3.36098300
29	reproduction (GO:0000003)	3.34588681
30	positive regulation of catecholamine secretion (GO:0033605)	3.33400641
31	glycine transport (GO:0015816)	3.28475058
32	negative regulation of digestive system process (GO:0060457)	3.27603627
33	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.14861815
34	regulation of prostaglandin secretion (GO:0032306)	3.11510267
35	maturation of SSU-rRNA (GO:0030490)	3.07619741
36	cellular response to pH (GO:0071467)	3.02003132
37	binding of sperm to zona pellucida (GO:0007339)	2.95203374
38	male meiosis (GO:0007140)	2.89885932
39	rRNA modification (GO:0000154)	2.83663670
40	regulation of norepinephrine secretion (GO:0014061)	2.74489298
41	transcription from mitochondrial promoter (GO:0006390)	2.73730611
42	positive regulation of reproductive process (GO:2000243)	2.71419089
43	rRNA methylation (GO:0031167)	2.66573231
44	maternal behavior (GO:0042711)	2.66043001
45	mitotic metaphase plate congression (GO:0007080)	2.53856437
46	chromosome condensation (GO:0030261)	2.52008335
47	regulation of mitotic spindle organization (GO:0060236)	2.43839001
48	telomere maintenance via telomere lengthening (GO:0010833)	2.43404891
49	meiotic cell cycle (GO:0051321)	2.40061361
50	N-terminal protein amino acid acetylation (GO:0006474)	2.38267935
51	regulation of spindle organization (GO:0090224)	2.36836507
52	chaperone-mediated protein transport (GO:0072321)	2.35651027
53	sperm-egg recognition (GO:0035036)	2.35181154
54	parental behavior (GO:0060746)	2.32411610
55	positive regulation of icosanoid secretion (GO:0032305)	2.30010997
56	single fertilization (GO:0007338)	2.29522342
57	L-amino acid import (GO:0043092)	2.29130840
58	autophagic vacuole assembly (GO:0000045)	2.28806152
59	termination of RNA polymerase III transcription (GO:0006386)	2.28702216
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.28702216
61	ribosome assembly (GO:0042255)	2.27558561
62	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.21433144
63	response to food (GO:0032094)	2.19976285
64	histone H3-K9 demethylation (GO:0033169)	2.19507856
65	protein K6-linked ubiquitination (GO:0085020)	2.18577806
66	ventricular cardiac muscle cell development (GO:0055015)	2.18236872
67	positive regulation of protein homooligomerization (GO:0032464)	2.17857122
68	meiotic nuclear division (GO:0007126)	2.16898056
69	positive regulation of renal sodium excretion (GO:0035815)	2.13519931
70	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.12272082
71	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.11084439
72	positive regulation of fatty acid transport (GO:2000193)	2.07984148
73	DNA packaging (GO:0006323)	2.05973025
74	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.01396518
75	regulation of reproductive process (GO:2000241)	2.01166243
76	regulation of steroid hormone secretion (GO:2000831)	2.00168301
77	muscle organ morphogenesis (GO:0048644)	2.00146602
78	metaphase plate congression (GO:0051310)	1.99475313
79	fertilization (GO:0009566)	1.96355000
80	grooming behavior (GO:0007625)	1.94969211
81	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	1.92945667
82	viral transcription (GO:0019083)	1.91954881
83	translational termination (GO:0006415)	1.91381048
84	regulation of RNA export from nucleus (GO:0046831)	1.90490533
85	regulation of exit from mitosis (GO:0007096)	1.89997362
86	snRNA transcription (GO:0009301)	1.89525511
87	protein localization to chromosome, centromeric region (GO:0071459)	1.89345095
88	piRNA metabolic process (GO:0034587)	1.88387193
89	meiotic cell cycle process (GO:1903046)	1.87566196
90	cell-cell recognition (GO:0009988)	1.86236406
91	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	1.85234159
92	regulation of histone H3-K9 methylation (GO:0051570)	1.84313592
93	regulation of cell cycle G2/M phase transition (GO:1902749)	1.84007198
94	DNA replication initiation (GO:0006270)	1.83824533
95	negative regulation of RNA splicing (GO:0033119)	1.82770739
96	regulation of urine volume (GO:0035809)	1.79547138
97	sensory perception of taste (GO:0050909)	1.78908529
98	transcription elongation from RNA polymerase II promoter (GO:0006368)	1.78240423
99	polyamine biosynthetic process (GO:0006596)	1.76696891
100	positive regulation of chromosome segregation (GO:0051984)	1.76295278

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.57464203
2	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	5.24592011
3	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	5.24592011
4	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	5.24592011
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.91635870
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.79888591
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.12867527
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.99333527
9	ZNF274_21170338_ChIP-Seq_K562_Hela	3.58490913
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.50697223
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.42709723
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.15923591
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.96445687
14	* ETV1_20927104_ChIP-Seq_GIST48_Human	2.80865591
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.80421380
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.75953529
17	* RBPJ_21746931_ChIP-Seq_IB4_Human	2.64900681
18	E2F7_22180533_ChIP-Seq_HELA_Human	2.64661665
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.56732494
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47486251
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.42201336
22	* NFYB_21822215_ChIP-Seq_K562_Human	2.39435849
23	* TBL1_22424771_ChIP-Seq_293T_Human	2.34801171
24	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.31092656
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31077479
26	GATA6_21074721_ChIP-Seq_CACO-2_Human	2.22764237
27	* PHF8_20622853_ChIP-Seq_HELA_Human	2.20706364
28	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	2.14664351
29	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	2.07773952
30	MYC_18940864_ChIP-ChIP_HL60_Human	2.05350848
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00839830
32	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.88541248
33	AR_21909140_ChIP-Seq_LNCAP_Human	1.86415661
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.75791122
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.70190269
36	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.67609365
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65095151
38	NFYA_21822215_ChIP-Seq_K562_Human	1.61127787
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58093763
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.55484846
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.51221905
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.46416317
43	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.44628837
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43089181
45	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.36983947
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33895505
47	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30424595
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.30392524
49	STAT1_20625510_ChIP-Seq_HELA_Human	1.29764441
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22520203
51	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.22288875
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21846419
53	SOX2_21211035_ChIP-Seq_LN229_Human	1.19695690
54	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.19490733
55	* PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.18860415
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.13831758
57	E2F1_20622854_ChIP-Seq_HELA_Human	1.12623064
58	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.12263228
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11583078
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.09160981
61	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.08036754
62	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.07639849
63	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07364914
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06893667
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.06854054
66	CTCF_20526341_ChIP-Seq_ESCs_Human	1.06349546
67	* RAC3_21632823_ChIP-Seq_H3396_Human	1.01936148
68	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01703898
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01049107
70	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.96388407
71	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96087856
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95893714
73	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.94471451
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93837021
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91688791
76	TP53_22573176_ChIP-Seq_HFKS_Human	0.91456065
77	IRF1_19129219_ChIP-ChIP_H3396_Human	0.90344972
78	ELK1_19687146_ChIP-ChIP_HELA_Human	0.89876596
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.87245325
80	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.87137197
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86446794
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.85022934
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83112237
84	NCOR_22424771_ChIP-Seq_293T_Human	0.81416809
85	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80072054
86	* CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.77559603
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.77369452
88	CTCF_21964334_Chip-Seq_Bcells_Human	0.76797481
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.76411525
90	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.72948130
91	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.72765540
92	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.70617640
93	CIITA_25753668_ChIP-Seq_RAJI_Human	0.70409451
94	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.70225989
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.68935074
96	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.67289409
97	PHF8_20622854_ChIP-Seq_HELA_Human	0.63397599
98	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.63285116
99	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.62520652
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.62380870

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.29433611
2	MP0003718_maternal_effect	5.25307410
3	MP0001986_abnormal_taste_sensitivity	4.73565412
4	MP0005423_abnormal_somatic_nervous	4.24906087
5	MP0009379_abnormal_foot_pigmentation	3.86950082
6	MP0005394_taste/olfaction_phenotype	3.21313725
7	MP0005499_abnormal_olfactory_system	3.21313725
8	MP0005410_abnormal_fertilization	2.95359088
9	MP0003693_abnormal_embryo_hatching	2.83289075
10	MP0010307_abnormal_tumor_latency	2.80921932
11	MP0002127_abnormal_cardiovascular_syste	2.58339735
12	MP0009840_abnormal_foam_cell	2.54954309
13	MP0001929_abnormal_gametogenesis	2.49906487
14	MP0005360_urolithiasis	2.44127400
15	MP0002210_abnormal_sex_determination	2.39336466
16	MP0006276_abnormal_autonomic_nervous	2.30657054
17	MP0008877_abnormal_DNA_methylation	2.26018461
18	MP0002160_abnormal_reproductive_system	2.24028871
19	MP0003077_abnormal_cell_cycle	2.20070925
20	MP0005395_other_phenotype	2.18087855
21	MP0003111_abnormal_nucleus_morphology	2.17496208
22	MP0008789_abnormal_olfactory_epithelium	2.12351299
23	MP0001881_abnormal_mammary_gland	2.11998727
24	MP0002277_abnormal_respiratory_mucosa	2.11161363
25	MP0004957_abnormal_blastocyst_morpholog	2.10409836
26	MP0005647_abnormal_sex_gland	1.98693193
27	MP0003699_abnormal_female_reproductive	1.88424871
28	MP0002138_abnormal_hepatobiliary_system	1.87488087
29	MP0009333_abnormal_splenocyte_physiolog	1.78603407
30	MP0005389_reproductive_system_phenotype	1.77677935
31	MP0010094_abnormal_chromosome_stability	1.75198566
32	MP0010030_abnormal_orbit_morphology	1.69055595
33	MP0003646_muscle_fatigue	1.68787767
34	MP0008057_abnormal_DNA_replication	1.67752456
35	MP0000653_abnormal_sex_gland	1.67724798
36	MP0005646_abnormal_pituitary_gland	1.65622474
37	MP0008058_abnormal_DNA_repair	1.64945956
38	MP0001502_abnormal_circadian_rhythm	1.61170816
39	MP0002161_abnormal_fertility/fecundity	1.57151695
40	MP0002254_reproductive_system_inflammat	1.44435596
41	MP0003698_abnormal_male_reproductive	1.43766073
42	MP0003950_abnormal_plasma_membrane	1.39273040
43	MP0003195_calcinosis	1.34313510
44	MP0001145_abnormal_male_reproductive	1.34000412
45	MP0004142_abnormal_muscle_tone	1.30579124
46	MP0008932_abnormal_embryonic_tissue	1.27020524
47	MP0005380_embryogenesis_phenotype	1.22882101
48	MP0001672_abnormal_embryogenesis/_devel	1.22882101
49	MP0001545_abnormal_hematopoietic_system	1.22699129
50	MP0005397_hematopoietic_system_phenotyp	1.22699129
51	MP0003136_yellow_coat_color	1.20442402
52	MP0001119_abnormal_female_reproductive	1.19712382
53	MP0010368_abnormal_lymphatic_system	1.18941061
54	MP0008260_abnormal_autophagy	1.11927921
55	MP0000372_irregular_coat_pigmentation	1.11770706
56	MP0000350_abnormal_cell_proliferation	1.10081301
57	MP0001730_embryonic_growth_arrest	1.06625695
58	MP0000627_abnormal_mammary_gland	1.02042301
59	MP0003879_abnormal_hair_cell	0.99629477
60	MP0001293_anophthalmia	0.98687768
61	MP0004215_abnormal_myocardial_fiber	0.96193358
62	MP0003121_genomic_imprinting	0.95663960
63	MP0002233_abnormal_nose_morphology	0.95386542
64	MP0003938_abnormal_ear_development	0.94916143
65	MP0000049_abnormal_middle_ear	0.90986693
66	MP0003984_embryonic_growth_retardation	0.88699585
67	MP0001919_abnormal_reproductive_system	0.88287091
68	MP0001529_abnormal_vocalization	0.85196801
69	MP0005451_abnormal_body_composition	0.84504752
70	MP0002088_abnormal_embryonic_growth/wei	0.82310517
71	MP0004233_abnormal_muscle_weight	0.77499358
72	MP0001968_abnormal_touch/_nociception	0.77004430
73	MP0001666_abnormal_nutrient_absorption	0.76341815
74	MP0001697_abnormal_embryo_size	0.75894787
75	MP0000631_abnormal_neuroendocrine_gland	0.75255776
76	MP0002234_abnormal_pharynx_morphology	0.75106229
77	MP0002139_abnormal_hepatobiliary_system	0.74887906
78	MP0003936_abnormal_reproductive_system	0.74062068
79	MP0001440_abnormal_grooming_behavior	0.71916638
80	MP0000762_abnormal_tongue_morphology	0.69056079
81	MP0008995_early_reproductive_senescence	0.62865379
82	MP0002873_normal_phenotype	0.62453180
83	MP0002169_no_abnormal_phenotype	0.62164285
84	MP0002269_muscular_atrophy	0.60862525
85	MP0006036_abnormal_mitochondrial_physio	0.60432913
86	MP0003283_abnormal_digestive_organ	0.58342355
87	MP0005197_abnormal_uvea_morphology	0.57595259
88	MP0002080_prenatal_lethality	0.57217991
89	MP0004019_abnormal_vitamin_homeostasis	0.55911045
90	MP0003941_abnormal_skin_development	0.55199901
91	MP0005551_abnormal_eye_electrophysiolog	0.55096725
92	MP0003866_abnormal_defecation	0.54313522
93	MP0002084_abnormal_developmental_patter	0.54080635
94	MP0002085_abnormal_embryonic_tissue	0.52189191
95	MP0002736_abnormal_nociception_after	0.50917842
96	MP0001984_abnormal_olfaction	0.50463591
97	MP0003890_abnormal_embryonic-extraembry	0.49747462
98	MP0001324_abnormal_eye_pigmentation	0.49435124
99	MP0005085_abnormal_gallbladder_physiolo	0.49111470
100	MP0003186_abnormal_redox_activity	0.47849024

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	8.71466826
2	Malnutrition (HP:0004395)	7.15666752
3	Premature ovarian failure (HP:0008209)	5.57833941
4	Hypoplasia of the fovea (HP:0007750)	4.80333543
5	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.80333543
6	Aplasia/hypoplasia of the uterus (HP:0008684)	4.67033467
7	Hypercortisolism (HP:0001578)	4.44204237
8	Rhinitis (HP:0012384)	4.25172620
9	Infertility (HP:0000789)	4.04728455
10	Carpal bone hypoplasia (HP:0001498)	4.00282553
11	Steatorrhea (HP:0002570)	3.80354207
12	Hypoplasia of the uterus (HP:0000013)	3.79297616
13	Myokymia (HP:0002411)	3.71925109
14	Sensory axonal neuropathy (HP:0003390)	3.69562251
15	Abnormality of the fovea (HP:0000493)	3.69054648
16	Anterior segment dysgenesis (HP:0007700)	3.57963146
17	Muscle stiffness (HP:0003552)	3.57661323
18	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.35774421
19	Periauricular skin pits (HP:0100277)	3.33035004
20	Preauricular pit (HP:0004467)	3.33035004
21	Abnormality of the septum pellucidum (HP:0007375)	3.30773420
22	Hypophosphatemic rickets (HP:0004912)	3.25615368
23	Birth length less than 3rd percentile (HP:0003561)	3.20682361
24	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.18034562
25	Fat malabsorption (HP:0002630)	3.13827699
26	Hypergonadotropic hypogonadism (HP:0000815)	3.06161804
27	Aplasia/Hypoplasia of the macula (HP:0008059)	3.01669617
28	Patent foramen ovale (HP:0001655)	2.99498056
29	Short tibia (HP:0005736)	2.86655959
30	Dysphonia (HP:0001618)	2.84897152
31	Reticulocytopenia (HP:0001896)	2.80656356
32	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.80072343
33	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.77737414
34	Aplasia/hypoplasia of the humerus (HP:0006507)	2.77678947
35	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.77371806
36	Impulsivity (HP:0100710)	2.77336275
37	Multiple enchondromatosis (HP:0005701)	2.74002965
38	Facial cleft (HP:0002006)	2.72202659
39	Congenital ichthyosiform erythroderma (HP:0007431)	2.68091938
40	Fused cervical vertebrae (HP:0002949)	2.63338609
41	Fibular aplasia (HP:0002990)	2.61651142
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.61163769
43	Adrenal overactivity (HP:0002717)	2.59294182
44	Constricted visual fields (HP:0001133)	2.57401769
45	Limb dystonia (HP:0002451)	2.54917523
46	Microretrognathia (HP:0000308)	2.51054522
47	Attenuation of retinal blood vessels (HP:0007843)	2.49649331
48	Glossoptosis (HP:0000162)	2.49536655
49	Absent septum pellucidum (HP:0001331)	2.47607643
50	Progressive sensorineural hearing impairment (HP:0000408)	2.45748936
51	Progressive muscle weakness (HP:0003323)	2.39508388
52	Progressive hearing impairment (HP:0001730)	2.38261294
53	Cleft eyelid (HP:0000625)	2.31455046
54	Abnormality of abdominal situs (HP:0011620)	2.30923860
55	Abdominal situs inversus (HP:0003363)	2.30923860
56	Abnormality of the ileum (HP:0001549)	2.28452068
57	Selective tooth agenesis (HP:0001592)	2.26452162
58	Cortical visual impairment (HP:0100704)	2.25627812
59	Delayed CNS myelination (HP:0002188)	2.24446793
60	Septo-optic dysplasia (HP:0100842)	2.20955973
61	Cone-rod dystrophy (HP:0000548)	2.20700510
62	Osteomalacia (HP:0002749)	2.20067881
63	Pendular nystagmus (HP:0012043)	2.19592958
64	Skin pits (HP:0100276)	2.18841474
65	Meckel diverticulum (HP:0002245)	2.16346840
66	Midline defect of the nose (HP:0004122)	2.13010605
67	Impaired proprioception (HP:0010831)	2.12421917
68	Nausea (HP:0002018)	2.09710685
69	Esotropia (HP:0000565)	2.09303254
70	Sparse lateral eyebrow (HP:0005338)	2.08213269
71	Secondary amenorrhea (HP:0000869)	2.05135807
72	Abnormal pancreas size (HP:0012094)	2.01259726
73	Abnormality of cells of the erythroid lineage (HP:0012130)	2.00618231
74	Atresia of the external auditory canal (HP:0000413)	1.98765847
75	Chronic sinusitis (HP:0011109)	1.97872487
76	Hypoplastic scapulae (HP:0000882)	1.97326549
77	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.97326549
78	Abnormality of the preputium (HP:0100587)	1.96050995
79	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.95241461
80	Absent radius (HP:0003974)	1.94302222
81	Abnormal ciliary motility (HP:0012262)	1.92944941
82	Ureteral duplication (HP:0000073)	1.92017514
83	Tetraparesis (HP:0002273)	1.87759384
84	Testicular atrophy (HP:0000029)	1.85773337
85	Abnormal number of erythroid precursors (HP:0012131)	1.85770434
86	Poor suck (HP:0002033)	1.85594654
87	Poor eye contact (HP:0000817)	1.85499641
88	Central scotoma (HP:0000603)	1.84769184
89	Absent thumb (HP:0009777)	1.84705015
90	Bony spicule pigmentary retinopathy (HP:0007737)	1.83817232
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83228151
92	Decreased central vision (HP:0007663)	1.83184386
93	Aplasia involving forearm bones (HP:0009822)	1.82752194
94	Absent forearm bone (HP:0003953)	1.82752194
95	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.82723144
96	Horizontal nystagmus (HP:0000666)	1.80779859
97	Cranial hyperostosis (HP:0004437)	1.77273834
98	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.77061918
99	Horseshoe kidney (HP:0000085)	1.76687075
100	Pili torti (HP:0003777)	1.76474998

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	6.21527867
2	BUB1	4.78681387
3	LATS2	4.74934498
4	SRPK1	4.12696102
5	CDK19	3.77342485
6	TRIM28	3.30323840
7	NEK6	3.21512469
8	BRSK2	3.14605422
9	STK16	3.10695148
10	BRSK1	2.62691386
11	PLK1	2.01444942
12	ZAK	1.99807848
13	MARK3	1.80290221
14	TLK1	1.79266227
15	EIF2AK3	1.73675885
16	NEK2	1.63073525
17	MAP3K9	1.62441542
18	AURKB	1.60502590
19	PLK3	1.56089851
20	CDK7	1.49173505
21	PRKCI	1.48685441
22	DYRK3	1.46287360
23	AURKA	1.36924285
24	CDK9	1.35708437
25	TAOK3	1.32566552
26	CDC7	1.21034664
27	PKN1	1.20987157
28	LRRK2	1.16752616
29	MELK	1.14352478
30	GSK3A	1.13932302
31	PLK4	1.13532423
32	MAP3K5	1.13324705
33	PBK	1.11271728
34	CDK12	1.10349727
35	WNK1	1.10258565
36	CHEK1	1.08778190
37	NTRK3	1.07954874
38	STK3	1.07710801
39	PIM2	1.06088906
40	CSNK1E	1.03497786
41	PDK2	1.01181298
42	WNK3	1.00328176
43	NME1	1.00049173
44	STK24	0.88200595
45	TTK	0.83118466
46	CSNK2A2	0.78894082
47	CHEK2	0.77332669
48	CSNK2A1	0.75052482
49	PAK1	0.75035025
50	WEE1	0.74950493
51	PIM1	0.71825202
52	ACVR1B	0.70704517
53	CDK2	0.69507930
54	ATR	0.69005336
55	KDR	0.67587968
56	RAF1	0.65601192
57	STK4	0.64626418
58	AKT2	0.61179369
59	PAK2	0.58030108
60	CDK1	0.54142858
61	VRK1	0.47061522
62	STK38L	0.44485500
63	BRD4	0.41812978
64	EIF2AK1	0.40669671
65	MAPK11	0.40268040
66	MTOR	0.39939412
67	STK10	0.36348629
68	ATM	0.32434600
69	PRKG1	0.32266671
70	GSK3B	0.31872277
71	TAOK2	0.29945030
72	ARAF	0.29019050
73	CLK1	0.28705698
74	INSRR	0.27833595
75	MAPK1	0.27559505
76	DMPK	0.27100293
77	PLK2	0.26062108
78	PRKD1	0.26037433
79	PRKCG	0.25554331
80	CDK11A	0.24546840
81	MAP3K8	0.24348385
82	MAPK14	0.23496901
83	STK39	0.22174678
84	PDK1	0.21860422
85	CSNK1D	0.21476319
86	EIF2AK2	0.20930511
87	MAPK9	0.20467672
88	BCKDK	0.18578803
89	CAMK1	0.18524978
90	RPS6KA1	0.18071146
91	TESK1	0.17493218
92	OXSR1	0.16977250
93	VRK2	0.16917742
94	PIK3CG	0.15767114
95	CSNK1A1	0.14830494
96	ABL2	0.14750293
97	BMPR1B	0.14695800
98	PRKCE	0.14413642
99	PRKAA1	0.13752166
100	MAPK10	0.12811199

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	6.27612408
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.43842112
3	Ribosome_Homo sapiens_hsa03010	3.88583234
4	RNA polymerase_Homo sapiens_hsa03020	3.79916093
5	mRNA surveillance pathway_Homo sapiens_hsa03015	3.62632430
6	Regulation of autophagy_Homo sapiens_hsa04140	3.26883836
7	Cell cycle_Homo sapiens_hsa04110	3.21464857
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.93347978
9	RNA transport_Homo sapiens_hsa03013	2.86360021
10	Folate biosynthesis_Homo sapiens_hsa00790	2.78936421
11	Spliceosome_Homo sapiens_hsa03040	2.61397185
12	Taste transduction_Homo sapiens_hsa04742	2.58170977
13	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.56679080
14	Oocyte meiosis_Homo sapiens_hsa04114	2.51231035
15	p53 signaling pathway_Homo sapiens_hsa04115	2.32438538
16	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.22886039
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75622359
18	Base excision repair_Homo sapiens_hsa03410	1.55150304
19	Mismatch repair_Homo sapiens_hsa03430	1.37875400
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36807104
21	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.22657791
22	RNA degradation_Homo sapiens_hsa03018	1.20834715
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20319627
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.20314510
25	Olfactory transduction_Homo sapiens_hsa04740	1.17434355
26	DNA replication_Homo sapiens_hsa03030	1.16569085
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14976924
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.14070039
29	Viral carcinogenesis_Homo sapiens_hsa05203	1.13140242
30	Huntingtons disease_Homo sapiens_hsa05016	1.05858322
31	Sulfur metabolism_Homo sapiens_hsa00920	1.04812421
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.94693120
33	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.93782182
34	Nucleotide excision repair_Homo sapiens_hsa03420	0.89886915
35	Homologous recombination_Homo sapiens_hsa03440	0.84380683
36	Purine metabolism_Homo sapiens_hsa00230	0.83077068
37	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.79156367
38	Steroid biosynthesis_Homo sapiens_hsa00100	0.77691530
39	Fatty acid elongation_Homo sapiens_hsa00062	0.74807453
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.73428925
41	MicroRNAs in cancer_Homo sapiens_hsa05206	0.72943323
42	Serotonergic synapse_Homo sapiens_hsa04726	0.70343439
43	Caffeine metabolism_Homo sapiens_hsa00232	0.68606038
44	Herpes simplex infection_Homo sapiens_hsa05168	0.68517791
45	ABC transporters_Homo sapiens_hsa02010	0.65891185
46	Parkinsons disease_Homo sapiens_hsa05012	0.65725076
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.62514393
48	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.62411646
49	Wnt signaling pathway_Homo sapiens_hsa04310	0.57282397
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54718293
51	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53780101
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48803830
53	Insulin secretion_Homo sapiens_hsa04911	0.45951071
54	Hepatitis B_Homo sapiens_hsa05161	0.44494370
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44108903
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42908353
57	Proteasome_Homo sapiens_hsa03050	0.42735944
58	Morphine addiction_Homo sapiens_hsa05032	0.41880550
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40100155
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39001035
61	Mineral absorption_Homo sapiens_hsa04978	0.37770595
62	Protein digestion and absorption_Homo sapiens_hsa04974	0.37753577
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37334902
64	Bile secretion_Homo sapiens_hsa04976	0.36590957
65	AMPK signaling pathway_Homo sapiens_hsa04152	0.36346131
66	Nicotine addiction_Homo sapiens_hsa05033	0.35511979
67	Acute myeloid leukemia_Homo sapiens_hsa05221	0.35283502
68	GABAergic synapse_Homo sapiens_hsa04727	0.35266718
69	Small cell lung cancer_Homo sapiens_hsa05222	0.34439067
70	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29837090
71	Alcoholism_Homo sapiens_hsa05034	0.27909229
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25996292
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.25452783
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24353567
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.24169115
76	Protein export_Homo sapiens_hsa03060	0.22631265
77	Amphetamine addiction_Homo sapiens_hsa05031	0.20940283
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17741654
79	FoxO signaling pathway_Homo sapiens_hsa04068	0.16895870
80	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.16645879
81	Legionellosis_Homo sapiens_hsa05134	0.15631782
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.14101266
83	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.13218223
84	Influenza A_Homo sapiens_hsa05164	0.13207672
85	Pancreatic secretion_Homo sapiens_hsa04972	0.12216304
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.11439929
87	Sphingolipid metabolism_Homo sapiens_hsa00600	0.11121193
88	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.10931831
89	Metabolic pathways_Homo sapiens_hsa01100	0.10930647
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.09023469
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.08173835
92	mTOR signaling pathway_Homo sapiens_hsa04150	0.07469233
93	Circadian entrainment_Homo sapiens_hsa04713	0.04834679
94	Pathways in cancer_Homo sapiens_hsa05200	0.04814986
95	Oxidative phosphorylation_Homo sapiens_hsa00190	0.03793158
96	HTLV-I infection_Homo sapiens_hsa05166	0.03687883
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.03589784
98	Retinol metabolism_Homo sapiens_hsa00830	0.02898400
99	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.02700673
100	Glutathione metabolism_Homo sapiens_hsa00480	0.02178630

PRAMEF11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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