PRAMEF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.18057403
2mesenchymal cell differentiation involved in renal system development (GO:2001012)6.11033921
3mesenchymal cell differentiation involved in kidney development (GO:0072161)6.11033921
4male meiosis I (GO:0007141)6.04423411
5mitotic metaphase plate congression (GO:0007080)6.00266063
6histone H2A monoubiquitination (GO:0035518)5.86747093
7mitotic chromosome condensation (GO:0007076)5.76654337
8regulation of female gonad development (GO:2000194)5.29268695
9metaphase plate congression (GO:0051310)5.09996725
10DNA methylation involved in gamete generation (GO:0043046)5.02636152
11meiosis I (GO:0007127)5.01329761
12drinking behavior (GO:0042756)4.97213804
13female gamete generation (GO:0007292)4.96379174
14mitotic sister chromatid segregation (GO:0000070)4.89543596
15attachment of spindle microtubules to kinetochore (GO:0008608)4.85970258
16histone H2A ubiquitination (GO:0033522)4.80991115
17protein localization to kinetochore (GO:0034501)4.74022612
18protein K6-linked ubiquitination (GO:0085020)4.69709481
19regulation of sister chromatid cohesion (GO:0007063)4.63841352
20establishment of chromosome localization (GO:0051303)4.62979483
21regulation of meiosis I (GO:0060631)4.56255309
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.50489203
23meiotic cell cycle (GO:0051321)4.46036811
24negative regulation of meiosis (GO:0045835)4.43324790
25regulation of meiosis (GO:0040020)4.39366002
26protein localization to chromosome, centromeric region (GO:0071459)4.34619363
27regulation of exit from mitosis (GO:0007096)4.31297170
28mitotic nuclear envelope disassembly (GO:0007077)4.30348868
29positive regulation of uterine smooth muscle contraction (GO:0070474)4.25034905
30DNA replication checkpoint (GO:0000076)4.20455761
31meiotic chromosome segregation (GO:0045132)4.18570542
32regulation of spindle organization (GO:0090224)4.15131207
33positive regulation of digestive system process (GO:0060456)4.09628765
34positive regulation of chromosome segregation (GO:0051984)4.08248723
35membrane disassembly (GO:0030397)4.06712376
36nuclear envelope disassembly (GO:0051081)4.06712376
37sister chromatid segregation (GO:0000819)4.05629453
38gene silencing by RNA (GO:0031047)4.02528895
39male meiosis (GO:0007140)4.02226296
40* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)35.5686802
41DNA alkylation (GO:0006305)3.95564229
42DNA methylation (GO:0006306)3.95564229
43oocyte maturation (GO:0001556)3.94503821
44negative regulation of histone methylation (GO:0031061)3.91688966
45regulation of mitotic spindle organization (GO:0060236)3.84962125
46protein localization to chromosome (GO:0034502)3.83851288
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.81723219
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.81723219
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.81723219
50chromosome segregation (GO:0007059)3.78492363
51DNA replication-dependent nucleosome organization (GO:0034723)3.78249520
52DNA replication-dependent nucleosome assembly (GO:0006335)3.78249520
53kinetochore assembly (GO:0051382)3.76569400
54multicellular organism reproduction (GO:0032504)3.74635618
55nuclear pore complex assembly (GO:0051292)3.74189444
56regulation of chromosome segregation (GO:0051983)3.72389709
57regulation of DNA methylation (GO:0044030)3.71847261
58spindle checkpoint (GO:0031577)3.71578189
59positive regulation of endothelial cell differentiation (GO:0045603)3.71345602
60kinetochore organization (GO:0051383)3.70923523
61negative regulation of smooth muscle cell differentiation (GO:0051151)3.70425587
62chromatin remodeling at centromere (GO:0031055)3.68837343
63synaptonemal complex assembly (GO:0007130)3.67729288
64CENP-A containing nucleosome assembly (GO:0034080)3.67201836
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.67170841
66maturation of 5.8S rRNA (GO:0000460)3.66947497
67regulation of cytokine production involved in inflammatory response (GO:1900015)3.65134118
68nuclear pore organization (GO:0006999)3.64721068
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.62005888
70negative regulation of reproductive process (GO:2000242)3.60728832
71notochord development (GO:0030903)3.59072785
72DNA replication-independent nucleosome assembly (GO:0006336)3.58677406
73DNA replication-independent nucleosome organization (GO:0034724)3.58677406
74negative regulation of chromosome segregation (GO:0051985)3.50709277
75regulation of histone H3-K27 methylation (GO:0061085)3.49871568
76oogenesis (GO:0048477)3.46929687
77mitotic spindle checkpoint (GO:0071174)3.46316131
78DNA damage induced protein phosphorylation (GO:0006975)3.45441883
79histone exchange (GO:0043486)3.41977544
80ribosome assembly (GO:0042255)3.41675547
81regulation of meiotic cell cycle (GO:0051445)3.40422030
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40012436
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39138664
84base-excision repair, AP site formation (GO:0006285)3.38510565
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.37530669
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37530669
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37530669
88negative regulation of sister chromatid segregation (GO:0033046)3.37530669
89DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.36366172
90mitotic spindle assembly checkpoint (GO:0007094)3.36263967
91spindle assembly checkpoint (GO:0071173)3.32570021
92negative regulation of DNA-templated transcription, elongation (GO:0032785)3.31271907
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.31271907
94nuclear envelope organization (GO:0006998)3.30920269
95DNA damage response, signal transduction resulting in transcription (GO:0042772)3.30489176
96regulation of sister chromatid segregation (GO:0033045)3.29703107
97regulation of mitotic sister chromatid separation (GO:0010965)3.29703107
98regulation of mitotic sister chromatid segregation (GO:0033047)3.29703107
99regulation of uterine smooth muscle contraction (GO:0070472)3.29050915
100intestinal epithelial cell development (GO:0060576)3.27684855
101artery development (GO:0060840)3.27123965
102mitotic sister chromatid cohesion (GO:0007064)3.26807177
103regulation of telomere maintenance via telomerase (GO:0032210)3.26614005
104inner cell mass cell proliferation (GO:0001833)3.24574597
105synaptonemal complex organization (GO:0070193)3.23997179
106chromatin assembly or disassembly (GO:0006333)3.23172965
107regulation of acrosome reaction (GO:0060046)3.20465799
108regulation of G0 to G1 transition (GO:0070316)3.20389951
109negative regulation of meiotic cell cycle (GO:0051447)3.18868559
110regulation of double-strand break repair via homologous recombination (GO:0010569)3.18480175
111pre-miRNA processing (GO:0031054)3.17030024
112meiotic cell cycle process (GO:1903046)3.15829941
113histone monoubiquitination (GO:0010390)3.15015860
114regulation of centrosome cycle (GO:0046605)3.12195400
115regulation of gene silencing by miRNA (GO:0060964)3.11111584
116regulation of gene silencing by RNA (GO:0060966)3.11111584
117lymphangiogenesis (GO:0001946)3.11098255
118regulation of urine volume (GO:0035809)3.08416734
119protein kinase C signaling (GO:0070528)3.03980124
120aggressive behavior (GO:0002118)3.00897084
121regulation of somitogenesis (GO:0014807)3.00801570
122* regulation of retinoic acid receptor signaling pathway (GO:0048385)29.7920592
123positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.92760896
124protein prenylation (GO:0018342)2.85301955
125prenylation (GO:0097354)2.85301955
126sleep (GO:0030431)2.83741082
127activin receptor signaling pathway (GO:0032924)2.82477239
128primitive streak formation (GO:0090009)2.81796352
129histone H3-K9 demethylation (GO:0033169)2.80898188
130regulation of female receptivity (GO:0045924)2.71264038
131glycine transport (GO:0015816)2.69523312
132positive regulation of protein homooligomerization (GO:0032464)2.69375643
133hyperosmotic salinity response (GO:0042538)2.68003500
134regulation of posttranscriptional gene silencing (GO:0060147)2.66961992
135DNA integration (GO:0015074)2.66344802
136oocyte development (GO:0048599)2.63224477
137regulation of mesoderm development (GO:2000380)2.63197148
138cellular response to pH (GO:0071467)2.63160089
139lung-associated mesenchyme development (GO:0060484)2.61637657
140thalamus development (GO:0021794)2.59292147
141regulation of endothelial cell differentiation (GO:0045601)2.57997546
142cilium or flagellum-dependent cell motility (GO:0001539)2.55741529
143regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.55456913
144blood vessel maturation (GO:0001955)2.54817989
145regulation of penile erection (GO:0060405)2.49949802
146positive regulation of SMAD protein import into nucleus (GO:0060391)2.46262721
147ventricular cardiac muscle cell development (GO:0055015)2.45068244
148L-amino acid import (GO:0043092)2.42916472
149positive regulation of reproductive process (GO:2000243)2.41364738
150G-protein coupled receptor internalization (GO:0002031)2.41345492
151viral transcription (GO:0019083)2.40303328
152positive regulation of catecholamine secretion (GO:0033605)2.38783790
153amino acid import (GO:0043090)2.38640805
154nodal signaling pathway (GO:0038092)2.38551118
155sulfation (GO:0051923)2.38341342
156positive regulation of prostaglandin secretion (GO:0032308)2.37794685
157regulation of SMAD protein import into nucleus (GO:0060390)2.35783264
158post-anal tail morphogenesis (GO:0036342)2.32712346
159reproduction (GO:0000003)2.32118465
160positive regulation of cAMP-mediated signaling (GO:0043950)2.31248547
161regulation of cell cycle G2/M phase transition (GO:1902749)2.30036109
162translational termination (GO:0006415)2.28900788
163positive regulation of humoral immune response (GO:0002922)2.28220995
164morphogenesis of an endothelium (GO:0003159)2.28003454
165endothelial tube morphogenesis (GO:0061154)2.28003454
166female mating behavior (GO:0060180)2.27037887
167type B pancreatic cell development (GO:0003323)2.24093493
168maternal behavior (GO:0042711)2.21917586
169response to acidic pH (GO:0010447)2.20654786
170retinal cone cell development (GO:0046549)2.19301582
171negative regulation of digestive system process (GO:0060457)2.17364460
172snRNA transcription (GO:0009301)2.16948468
173maturation of SSU-rRNA (GO:0030490)2.15146382
174meiotic nuclear division (GO:0007126)2.10922963
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.10690542
176negative regulation of homotypic cell-cell adhesion (GO:0034111)2.10680339
177regulation of reproductive process (GO:2000241)2.09950289
178regulation of histone H3-K9 methylation (GO:0051570)2.08377788
179left/right pattern formation (GO:0060972)2.07290225
180positive regulation of renal sodium excretion (GO:0035815)2.07075163
181positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.06592996
182cell migration involved in gastrulation (GO:0042074)2.06036121
183neuron projection extension involved in neuron projection guidance (GO:1902284)2.05987506
184axon extension involved in axon guidance (GO:0048846)2.05987506
185regulation of hippo signaling (GO:0035330)2.04681471
186dorsal/ventral neural tube patterning (GO:0021904)2.04658968
187negative regulation of DNA biosynthetic process (GO:2000279)2.03126279
188ribosome biogenesis (GO:0042254)2.02615794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.88034313
2EZH2_22144423_ChIP-Seq_EOC_Human7.17987502
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.71538351
4FOXM1_23109430_ChIP-Seq_U2OS_Human6.28940299
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.90668621
6NOTCH1_21737748_ChIP-Seq_TLL_Human4.70705584
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40264090
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.37249621
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.81833375
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.81210220
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53952139
12AR_21909140_ChIP-Seq_LNCAP_Human3.38512594
13ZNF274_21170338_ChIP-Seq_K562_Hela2.92463397
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.87734985
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.76041636
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75205222
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65058010
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49667227
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.27591506
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24489163
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.21580560
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11088103
23MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09631297
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03654117
25KAP1_22055183_ChIP-Seq_ESCs_Mouse2.02722752
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01189126
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01189126
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01189126
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99970381
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98205974
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97627685
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96099072
33VDR_22108803_ChIP-Seq_LS180_Human1.94254692
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91345900
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87612136
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84723140
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79780329
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79287495
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74322353
40NANOG_21062744_ChIP-ChIP_HESCs_Human1.74272379
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73940155
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.71829063
43* ETV1_20927104_ChIP-Seq_GIST48_Human1.71167952
44* TBL1_22424771_ChIP-Seq_293T_Human1.69063204
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.68981849
46NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.68367091
47* NFYB_21822215_ChIP-Seq_K562_Human1.66266206
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66083005
49* RBPJ_21746931_ChIP-Seq_IB4_Human1.64151488
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62966168
51IRF1_19129219_ChIP-ChIP_H3396_Human1.61696754
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.60418823
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57088314
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55149132
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.55028749
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.53619619
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.50931309
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.48541708
59GABP_19822575_ChIP-Seq_HepG2_Human1.46227824
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.45051296
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44581223
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.43335480
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43074142
64* PHF8_20622853_ChIP-Seq_HELA_Human1.43019625
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.41507557
66KDM5A_27292631_Chip-Seq_BREAST_Human1.37930754
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.37705920
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36368171
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34047509
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33304147
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33274642
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32865925
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32251189
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32000983
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31963143
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.30693303
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27581313
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25405713
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25179004
80MYC_18940864_ChIP-ChIP_HL60_Human1.25164929
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24843650
82NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24499400
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23331505
84* KAP1_27257070_Chip-Seq_ESCs_Mouse1.22357729
85XRN2_22483619_ChIP-Seq_HELA_Human1.19764074
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16891138
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16734579
88* HNFA_21074721_ChIP-Seq_CACO-2_Human1.16328861
89* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15146822
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14589186
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14554777
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13498116
93TTF2_22483619_ChIP-Seq_HELA_Human1.11966122
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11529958
95POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11220731
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10327962
97* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08952272
98VDR_23849224_ChIP-Seq_CD4+_Human1.08746064
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07378322
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05926392
101DCP1A_22483619_ChIP-Seq_HELA_Human1.04962457
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04103050
103* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04059071
104* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02849736
105EZH2_27304074_Chip-Seq_ESCs_Mouse1.01334872
106NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00634616
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.99007858
108* GATA6_21074721_ChIP-Seq_CACO-2_Human0.98969855
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98602143
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97988179
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97935000
112CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97468629
113AR_21572438_ChIP-Seq_LNCaP_Human0.96364825
114RAC3_21632823_ChIP-Seq_H3396_Human0.95752770
115SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95599192
116* NFYA_21822215_ChIP-Seq_K562_Human0.94928846
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93843821
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93800928
119ATF3_27146783_Chip-Seq_COLON_Human0.93495411
120STAT1_20625510_ChIP-Seq_HELA_Human0.92618076
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91669390
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91603049
123LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91247401
124GBX2_23144817_ChIP-Seq_PC3_Human0.90855072
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90796254
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90661566
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90207151
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89925434
129FOXP3_21729870_ChIP-Seq_TREG_Human0.89819854
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89757655
131MYC_22102868_ChIP-Seq_BL_Human0.89405657
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88694070
133RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88672953
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88609342
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88289878
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88006862
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.87129898
138TP53_22573176_ChIP-Seq_HFKS_Human0.86649168
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86473308
140CTCF_20526341_ChIP-Seq_ESCs_Human0.86368528
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85316587
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84708282
143NANOG_20526341_ChIP-Seq_ESCs_Human0.84568807
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83676381
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83491355
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81873505
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81375699
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81300519
149RNF2_27304074_Chip-Seq_NSC_Mouse0.80097616
150NANOG_16518401_ChIP-PET_MESCs_Mouse0.80008560
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79883652
152RUNX2_22187159_ChIP-Seq_PCA_Human0.79380142
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77687121
154BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77239558
155SOX2_21211035_ChIP-Seq_LN229_Human0.75819284
156SOX2_16153702_ChIP-ChIP_HESCs_Human0.73212517
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.73190924
158GATA3_26560356_Chip-Seq_TH1_Human0.73058228
159ELK1_19687146_ChIP-ChIP_HELA_Human0.72333848
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69452289
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.68250500
162TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.68103287
163RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67554875
164EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67554875
165GF1_26923725_Chip-Seq_HPCs_Mouse0.66608357
166KLF4_19829295_ChIP-Seq_ESCs_Human0.66204142
167* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.65949456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.66296100
2MP0003693_abnormal_embryo_hatching4.67039427
3MP0010368_abnormal_lymphatic_system4.27957633
4MP0008877_abnormal_DNA_methylation4.03688895
5MP0010094_abnormal_chromosome_stability3.94287953
6MP0004957_abnormal_blastocyst_morpholog3.89445524
7MP0003283_abnormal_digestive_organ3.89320725
8MP0003111_abnormal_nucleus_morphology3.74769886
9MP0003077_abnormal_cell_cycle3.50581314
10MP0003646_muscle_fatigue3.22941420
11MP0002138_abnormal_hepatobiliary_system3.22828951
12MP0001879_abnormal_lymphatic_vessel3.07877184
13MP0002653_abnormal_ependyma_morphology3.00399786
14MP0003123_paternal_imprinting2.82800406
15MP0003121_genomic_imprinting2.78551188
16MP0005451_abnormal_body_composition2.73626018
17MP0001293_anophthalmia2.63941166
18MP0004264_abnormal_extraembryonic_tissu2.55679748
19MP0008057_abnormal_DNA_replication2.54178358
20MP0002234_abnormal_pharynx_morphology2.47613046
21MP0003787_abnormal_imprinting2.40532098
22MP0005395_other_phenotype2.36023201
23MP0003183_abnormal_peptide_metabolism2.32325395
24MP0001730_embryonic_growth_arrest2.24232202
25MP0008932_abnormal_embryonic_tissue2.22954749
26MP0003699_abnormal_female_reproductive2.22586927
27MP0001929_abnormal_gametogenesis2.21001877
28MP0002210_abnormal_sex_determination2.19111831
29MP0001119_abnormal_female_reproductive2.12087453
30MP0009379_abnormal_foot_pigmentation2.11667879
31MP0000653_abnormal_sex_gland2.06198816
32MP0000350_abnormal_cell_proliferation2.00719258
33MP0005499_abnormal_olfactory_system1.98324356
34MP0005394_taste/olfaction_phenotype1.98324356
35MP0000049_abnormal_middle_ear1.97515350
36MP0001986_abnormal_taste_sensitivity1.95878040
37MP0008058_abnormal_DNA_repair1.95646866
38MP0005380_embryogenesis_phenotype1.93591837
39MP0001672_abnormal_embryogenesis/_devel1.93591837
40MP0006276_abnormal_autonomic_nervous1.90775668
41MP0003941_abnormal_skin_development1.88800640
42MP0005423_abnormal_somatic_nervous1.88717150
43MP0002102_abnormal_ear_morphology1.88625838
44MP0002085_abnormal_embryonic_tissue1.86716768
45MP0009384_cardiac_valve_regurgitation1.80540276
46MP0002084_abnormal_developmental_patter1.78421204
47MP0001697_abnormal_embryo_size1.78106751
48MP0002163_abnormal_gland_morphology1.73597153
49MP0001145_abnormal_male_reproductive1.69663949
50MP0008007_abnormal_cellular_replicative1.68162013
51MP0003937_abnormal_limbs/digits/tail_de1.67355183
52MP0003315_abnormal_perineum_morphology1.60832497
53MP0003195_calcinosis1.56007093
54MP0000428_abnormal_craniofacial_morphol1.55751156
55MP0003984_embryonic_growth_retardation1.54059774
56MP0002086_abnormal_extraembryonic_tissu1.52786707
57MP0006292_abnormal_olfactory_placode1.52450093
58MP0002088_abnormal_embryonic_growth/wei1.49068232
59MP0005410_abnormal_fertilization1.42452257
60MP0003786_premature_aging1.36284286
61MP0004272_abnormal_basement_membrane1.35375255
62MP0002161_abnormal_fertility/fecundity1.34669518
63MP0003890_abnormal_embryonic-extraembry1.31901329
64MP0004185_abnormal_adipocyte_glucose1.29220973
65MP0002080_prenatal_lethality1.28663420
66MP0002249_abnormal_larynx_morphology1.28648337
67MP0010307_abnormal_tumor_latency1.27263016
68MP0000579_abnormal_nail_morphology1.26010793
69MP0005360_urolithiasis1.24648397
70MP0008789_abnormal_olfactory_epithelium1.21474601
71MP0002796_impaired_skin_barrier1.18167246
72MP0003705_abnormal_hypodermis_morpholog1.17996094
73MP0009053_abnormal_anal_canal1.15399269
74MP0002233_abnormal_nose_morphology1.11598709
75MP0010352_gastrointestinal_tract_polyps1.10611819
76MP0005409_darkened_coat_color1.10593217
77MP0001915_intracranial_hemorrhage1.10460657
78MP0004233_abnormal_muscle_weight1.09321076
79MP0000762_abnormal_tongue_morphology1.08543798
80MP0002019_abnormal_tumor_incidence1.08439714
81MP0005171_absent_coat_pigmentation1.06122152
82MP0001544_abnormal_cardiovascular_syste1.05064473
83MP0005385_cardiovascular_system_phenoty1.05064473
84MP0005408_hypopigmentation1.05003235
85MP0005187_abnormal_penis_morphology1.02978964
86MP0002751_abnormal_autonomic_nervous1.02694454
87MP0003119_abnormal_digestive_system1.02543030
88MP0005076_abnormal_cell_differentiation1.01375048
89MP0004197_abnormal_fetal_growth/weight/1.00264209
90MP0000631_abnormal_neuroendocrine_gland0.99513866
91MP0000750_abnormal_muscle_regeneration0.98764298
92MP0003938_abnormal_ear_development0.97786378
93MP0004145_abnormal_muscle_electrophysio0.96801823
94MP0000383_abnormal_hair_follicle0.96385863
95MP0003828_pulmonary_edema0.96338760
96MP0003698_abnormal_male_reproductive0.92733891
97MP0000490_abnormal_crypts_of0.92126423
98MP0010234_abnormal_vibrissa_follicle0.91485340
99MP0008995_early_reproductive_senescence0.90901935
100MP0001849_ear_inflammation0.89010397
101MP0005621_abnormal_cell_physiology0.88767414
102MP0003755_abnormal_palate_morphology0.88402255
103MP0000313_abnormal_cell_death0.88237276
104MP0000462_abnormal_digestive_system0.88208599
105MP0002877_abnormal_melanocyte_morpholog0.87996590
106MP0002092_abnormal_eye_morphology0.87730807
107MP0002089_abnormal_postnatal_growth/wei0.86966621
108MP0001485_abnormal_pinna_reflex0.85031121
109MP0003453_abnormal_keratinocyte_physiol0.84913859
110MP0005646_abnormal_pituitary_gland0.84265648
111MP0003567_abnormal_fetal_cardiomyocyte0.81854615
112MP0009840_abnormal_foam_cell0.81833517
113MP0005384_cellular_phenotype0.81637131
114MP0005647_abnormal_sex_gland0.81472916
115MP0001881_abnormal_mammary_gland0.80868649
116MP0005389_reproductive_system_phenotype0.80105187
117MP0008260_abnormal_autophagy0.79637205
118MP0003950_abnormal_plasma_membrane0.78960499
119MP0001919_abnormal_reproductive_system0.77684436
120MP0004133_heterotaxia0.76561150
121MP0003136_yellow_coat_color0.76446566
122MP0001324_abnormal_eye_pigmentation0.75896796
123MP0000767_abnormal_smooth_muscle0.75781864
124MP0005023_abnormal_wound_healing0.75447611
125MP0003861_abnormal_nervous_system0.74655521
126MP0003385_abnormal_body_wall0.74285995
127MP0000678_abnormal_parathyroid_gland0.72895106
128MP0006138_congestive_heart_failure0.71343612
129MP0000432_abnormal_head_morphology0.67948526
130MP0000639_abnormal_adrenal_gland0.65521736
131MP0003806_abnormal_nucleotide_metabolis0.65461603
132MP0010030_abnormal_orbit_morphology0.64879355
133MP0003936_abnormal_reproductive_system0.64127551
134MP0003566_abnormal_cell_adhesion0.63490694
135MP0002127_abnormal_cardiovascular_syste0.62911132
136MP0003935_abnormal_craniofacial_develop0.62860685
137MP0002111_abnormal_tail_morphology0.58850203
138MP0006072_abnormal_retinal_apoptosis0.55354064
139MP0009672_abnormal_birth_weight0.52311339
140MP0003221_abnormal_cardiomyocyte_apopto0.52255527
141MP0001286_abnormal_eye_development0.52248788
142MP0005257_abnormal_intraocular_pressure0.51934417
143MP0002932_abnormal_joint_morphology0.51836446
144MP0010678_abnormal_skin_adnexa0.51626549
145MP0002160_abnormal_reproductive_system0.50811825
146MP0005310_abnormal_salivary_gland0.49529185
147MP0000627_abnormal_mammary_gland0.49150031
148MP0002269_muscular_atrophy0.48470102
149MP0002925_abnormal_cardiovascular_devel0.47949479
150MP0002116_abnormal_craniofacial_bone0.47389757
151MP0000613_abnormal_salivary_gland0.46874964
152MP0000733_abnormal_muscle_development0.45910328

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)8.31614007
2Asymmetry of the thorax (HP:0001555)7.52137320
3Abnormality of the lumbar spine (HP:0100712)6.33848454
4Thoracic kyphosis (HP:0002942)5.94780823
5Broad ribs (HP:0000885)5.58546869
6Male infertility (HP:0003251)5.45603833
7Chromsome breakage (HP:0040012)5.08641769
8Birth length less than 3rd percentile (HP:0003561)4.94058323
9Breast hypoplasia (HP:0003187)4.94045185
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77529391
11Abnormality of the labia minora (HP:0012880)4.69109275
12Fibular hypoplasia (HP:0003038)4.67026013
13Rough bone trabeculation (HP:0100670)4.66946862
14Natal tooth (HP:0000695)4.65133831
15Partial agenesis of the corpus callosum (HP:0001338)4.60125513
16Premature ovarian failure (HP:0008209)4.32468152
17Cortical dysplasia (HP:0002539)4.29034258
18Abnormality of the thoracic spine (HP:0100711)4.19942521
19Patellar aplasia (HP:0006443)4.12831107
20Shawl scrotum (HP:0000049)4.06385594
21Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.03262036
22Aplasia/Hypoplasia of the fovea (HP:0008060)4.01496828
23Hypoplasia of the fovea (HP:0007750)4.01496828
24Bilateral microphthalmos (HP:0007633)3.89346350
25Anal stenosis (HP:0002025)3.88181050
26Aplasia/Hypoplasia of the patella (HP:0006498)3.81136247
27Bifid uvula (HP:0000193)3.80134403
28Facial hemangioma (HP:0000329)3.77666461
29Aplasia/Hypoplasia of the fibula (HP:0006492)3.74898073
30Papillary thyroid carcinoma (HP:0002895)3.72103845
31Abnormal trabecular bone morphology (HP:0100671)3.70323347
32Impulsivity (HP:0100710)3.67936823
33Rhabdomyosarcoma (HP:0002859)3.46267306
34Secondary amenorrhea (HP:0000869)3.40926338
35Absent radius (HP:0003974)3.31917101
36Anomalous pulmonary venous return (HP:0010772)3.28495517
37Abnormality of the fovea (HP:0000493)3.24828412
38Fused cervical vertebrae (HP:0002949)3.22128292
39Delayed closure of the anterior fontanelle (HP:0001476)3.20812178
40Renal cortical cysts (HP:0000803)3.17867130
41Supernumerary spleens (HP:0009799)3.16963999
42Absent forearm bone (HP:0003953)3.15836093
43Aplasia involving forearm bones (HP:0009822)3.15836093
44Nasal speech (HP:0001611)3.07820873
45Abnormality of chromosome stability (HP:0003220)3.06687375
46Adrenal hypoplasia (HP:0000835)2.95679784
47Flat capital femoral epiphysis (HP:0003370)2.94746484
48Medulloblastoma (HP:0002885)2.94189707
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.92322609
50Subcapsular cataract (HP:0000523)2.89818168
51Thickened calvaria (HP:0002684)2.88682437
52Carpal bone hypoplasia (HP:0001498)2.88567841
53Stenosis of the external auditory canal (HP:0000402)2.86402350
54Meckel diverticulum (HP:0002245)2.86334756
55Neoplasm of the oral cavity (HP:0100649)2.85891210
56Abnormality of the pulmonary veins (HP:0011718)2.77663467
57Advanced eruption of teeth (HP:0006288)2.77366549
58Abnormality of the preputium (HP:0100587)2.76424172
59Breast aplasia (HP:0100783)2.75502008
60Aplasia/Hypoplasia of the macula (HP:0008059)2.74439427
61Ependymoma (HP:0002888)2.74336729
62Abnormality of the ileum (HP:0001549)2.72600911
63Tracheomalacia (HP:0002779)2.70435017
64Aplasia/Hypoplasia of the breasts (HP:0010311)2.70176350
65Abnormal number of incisors (HP:0011064)2.69461743
66Neoplasm of striated muscle (HP:0009728)2.69449044
67Sandal gap (HP:0001852)2.66335442
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65279170
69Oral leukoplakia (HP:0002745)2.65126493
70Selective tooth agenesis (HP:0001592)2.63902352
71Capillary hemangiomas (HP:0005306)2.62428938
72Abnormality of the fibula (HP:0002991)2.62234503
73Wide intermamillary distance (HP:0006610)2.60070429
74Thrombocytosis (HP:0001894)2.57960131
75Small intestinal stenosis (HP:0012848)2.55527960
76Duodenal stenosis (HP:0100867)2.55527960
77Microtia (HP:0008551)2.53035463
78Abnormality of chromosome segregation (HP:0002916)2.52876257
79Rib fusion (HP:0000902)2.52872463
80Aortic regurgitation (HP:0001659)2.52556001
81Aplasia/Hypoplasia affecting the retina (HP:0008061)2.50029809
82Cranial hyperostosis (HP:0004437)2.44767180
83Spontaneous hematomas (HP:0007420)2.42818385
84Hypergonadotropic hypogonadism (HP:0000815)2.42550170
85Infertility (HP:0000789)2.40447167
86Ectopic kidney (HP:0000086)2.37618222
87Azoospermia (HP:0000027)2.35775517
88Sloping forehead (HP:0000340)2.35635848
89Craniofacial hyperostosis (HP:0004493)2.35615641
90Sensory axonal neuropathy (HP:0003390)2.35252869
91Oligodactyly (hands) (HP:0001180)2.35221443
92Abnormality of the proximal phalanges of the hand (HP:0009834)2.34962227
93Oligodactyly (HP:0012165)2.33190025
94Overlapping toe (HP:0001845)2.28754855
95Spontaneous abortion (HP:0005268)2.27679495
96Short thumb (HP:0009778)2.26104772
97Insulin-resistant diabetes mellitus (HP:0000831)2.24257294
98Acute myeloid leukemia (HP:0004808)2.24033081
99Subacute progressive viral hepatitis (HP:0006572)2.20793453
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20678667
101Delayed puberty (HP:0000823)2.20621239
102Myelodysplasia (HP:0002863)2.18967132
103Aplasia/Hypoplasia of the sternum (HP:0006714)2.18348892
104Vertebral fusion (HP:0002948)2.14959674
105Sparse lateral eyebrow (HP:0005338)2.13365971
106Abnormality of the fingertips (HP:0001211)2.12984329
107Abnormality of lateral ventricle (HP:0030047)2.12330292
108Abnormality of the carotid arteries (HP:0005344)2.11680928
109Nephroblastoma (Wilms tumor) (HP:0002667)2.11497775
110Lip pit (HP:0100267)2.10588204
111Conjunctival telangiectasia (HP:0000524)2.09830615
112Aplasia/hypoplasia of the humerus (HP:0006507)2.09469473
113Cafe-au-lait spot (HP:0000957)2.09379856
114Nonimmune hydrops fetalis (HP:0001790)2.08022290
115Pulmonary fibrosis (HP:0002206)2.06941413
116Maternal diabetes (HP:0009800)2.06939606
117Abnormality of the duodenum (HP:0002246)2.05561523
118Short humerus (HP:0005792)2.05069690
119Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99858252
120Horseshoe kidney (HP:0000085)1.99292226
121Astrocytoma (HP:0009592)1.98909127
122Abnormality of the astrocytes (HP:0100707)1.98909127
123Anterior segment dysgenesis (HP:0007700)1.97759677
124Congenital ichthyosiform erythroderma (HP:0007431)1.96426085
125Embryonal renal neoplasm (HP:0011794)1.94488573
126Abnormality of the odontoid process (HP:0003310)1.93727540
127Aplasia/hypoplasia of the uterus (HP:0008684)1.93302305
128Primary amenorrhea (HP:0000786)1.89644899
129Lymphangioma (HP:0100764)1.88538116
130Clubbing of toes (HP:0100760)1.87061285
131Esophageal varix (HP:0002040)1.86934513
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85586750
133Agnosia (HP:0010524)1.84951732
134Myelomeningocele (HP:0002475)1.84851332
135Cerebral hypomyelination (HP:0006808)1.83003229
136Brittle hair (HP:0002299)1.82241846
137Colon cancer (HP:0003003)1.81883210
138Rhinitis (HP:0012384)1.81245890
139Abnormal lung lobation (HP:0002101)1.80774693
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80348869
141Short 1st metacarpal (HP:0010034)1.80348869
142Preauricular pit (HP:0004467)1.80079497
143Periauricular skin pits (HP:0100277)1.80079497
144Malnutrition (HP:0004395)1.79836262
145Urethral obstruction (HP:0000796)1.79493935
146Diastasis recti (HP:0001540)1.77696121
147Prominent nose (HP:0000448)1.77556579
148Thoracolumbar scoliosis (HP:0002944)1.77251493
149Hyperglycemia (HP:0003074)1.76629895
150Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76483282
151Abnormality of cochlea (HP:0000375)1.76472871
152Abnormality of the renal cortex (HP:0011035)1.76051685
153Abnormality of the septum pellucidum (HP:0007375)1.75171521
154Thyroid carcinoma (HP:0002890)1.74542724
155Hypoplasia of the uterus (HP:0000013)1.73100790
156Abnormal pancreas size (HP:0012094)1.72354113
157Hypogonadotrophic hypogonadism (HP:0000044)1.71583403
158Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70908605
159Polar cataract (HP:0010696)1.70793751
160Congenital sensorineural hearing impairment (HP:0008527)1.70445603
161Cystic hygroma (HP:0000476)1.70137301
162Abnormality of abdominal situs (HP:0011620)1.69873712
163Abdominal situs inversus (HP:0003363)1.69873712
164Anophthalmia (HP:0000528)1.68684632
165Bone marrow hypocellularity (HP:0005528)1.68151544
166Ankle contracture (HP:0006466)1.67864285
167Absent thumb (HP:0009777)1.67581668
168Septo-optic dysplasia (HP:0100842)1.67573125
169Malignant gastrointestinal tract tumors (HP:0006749)1.67312751
170Gastrointestinal carcinoma (HP:0002672)1.67312751
171Porencephaly (HP:0002132)1.67271038
172Abnormality of sulfur amino acid metabolism (HP:0004339)1.66716720
173Decreased circulating renin level (HP:0003351)1.66440390
174Concave nail (HP:0001598)1.64829390
175Glossoptosis (HP:0000162)1.64607226
176Abnormality of the labia (HP:0000058)1.64598492
177Wrist flexion contracture (HP:0001239)1.64157234
178Pili torti (HP:0003777)1.62717040
179Dental crowding (HP:0000678)1.61991645
180Hypercortisolism (HP:0001578)1.60855879
181Delayed cranial suture closure (HP:0000270)1.60370990
182Genetic anticipation (HP:0003743)1.59375185
183Overfolded helix (HP:0000396)1.58851983
184Absent eyebrow (HP:0002223)1.58851232
185Anal atresia (HP:0002023)1.58174948
186Abnormal spermatogenesis (HP:0008669)1.58159448
187Central scotoma (HP:0000603)1.58123434
188Unilateral renal agenesis (HP:0000122)1.56858961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.00478684
2PLK44.20578906
3LATS13.68633804
4TTK3.63196128
5LATS23.61603626
6MAP3K63.51217100
7CDC73.34266719
8CDK193.14104782
9STK38L2.91534887
10CDK122.67833781
11TAOK32.62827102
12ERBB42.47542248
13INSRR2.41181431
14NEK22.40481807
15EEF2K2.31220514
16BRAF2.29845465
17MAP3K92.22407501
18CHEK22.20720345
19MOS2.20209440
20KSR22.19890247
21BMPR1B2.18735960
22BUB12.17437659
23PLK11.93673693
24WEE11.92231249
25MAPKAPK31.89899937
26STK101.84059063
27RPS6KB21.71340011
28STK31.68017082
29TAOK11.67114919
30LMTK21.64768952
31CLK11.63147351
32STK161.61483654
33PTK21.57215599
34MELK1.57194968
35TEC1.56175080
36NUAK11.54976243
37ACVR1B1.54530119
38VRK21.49493349
39KDR1.47918441
40NEK11.45152623
41PRKD31.42549181
42TGFBR11.38646764
43MAP3K81.33911951
44RAF11.33836856
45CDK71.33112161
46CDK81.32559265
47PRKG21.31190384
48BMPR21.30882585
49TYRO31.28493135
50NEK61.27253686
51MUSK1.26290641
52AURKB1.23795102
53CDK91.23333000
54ARAF1.22376878
55EPHA21.14165293
56AURKA1.11970158
57CHEK11.10586677
58NTRK31.09671488
59SMG11.06849001
60GRK51.06645058
61TRIM281.04462802
62GSK3A1.04328886
63GRK11.00949141
64MAP3K130.97156557
65PLK30.93974325
66DYRK20.93731110
67CDK40.93322173
68ZAK0.93067595
69EIF2AK10.92820081
70ITK0.87502557
71PAK20.86109168
72KSR10.85868641
73EIF2AK30.83422429
74PIM20.79824409
75ATM0.79624455
76CAMK40.79324175
77STK380.77458019
78CSNK1G10.74605849
79PKN10.73522719
80ATR0.71487301
81MAP3K40.70823833
82NME10.70589873
83CDK20.69818291
84AKT30.69198921
85TAF10.68581401
86BRSK20.68523820
87PIK3CG0.64639089
88PAK60.64554861
89SRPK10.64536833
90MTOR0.62098064
91PRKD20.60445511
92OXSR10.60234501
93GRK70.60176317
94CDK10.57599706
95TLK10.56071340
96PRKCI0.53757905
97DYRK30.53656056
98PRKAA10.53618436
99FRK0.53545675
100MARK30.53032130
101RPS6KA50.51717326
102AKT20.50462904
103EPHB20.50046702
104PAK40.48248521
105CSNK1E0.45364233
106ABL20.44287010
107RET0.44152580
108PAK10.42101422
109CSNK1D0.41535921
110DAPK30.41508924
111CSNK1G30.41048208
112TGFBR20.41038290
113PIM10.40729847
114MAP3K30.40615148
115STK240.39173668
116BRSK10.38859347
117CSNK2A10.37601943
118WNK30.37283842
119RPS6KA40.37239895
120MAP3K50.37209097
121CSNK2A20.36815225
122STK390.36808194
123MAPK130.34683811
124CSNK1G20.34568980
125STK40.33184096
126VRK10.32619584
127PRKAA20.31372514
128MET0.30857479
129ICK0.30723912
130CHUK0.30267608
131ALK0.29569667
132PRKCG0.29365870
133PINK10.29304675
134IGF1R0.28762666
135WNK10.28353762
136PNCK0.28113986
137CDK60.27673948
138NLK0.27620382
139CSNK1A1L0.27611610
140MAPK140.27489411
141DMPK0.27111230
142TESK20.27062174
143AKT10.27044043
144PDK30.26862687
145PDK40.26862687
146MAPKAPK50.26610236
147BRD40.26074226
148GSK3B0.25377623
149MAPK10.25258619
150MAPK110.24428238
151MAPK100.23751033
152ABL10.21784202
153CDK30.21433872

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.90887850
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65308898
3Basal transcription factors_Homo sapiens_hsa030223.60824947
4Ribosome_Homo sapiens_hsa030103.50037129
5RNA transport_Homo sapiens_hsa030133.38212961
6RNA degradation_Homo sapiens_hsa030183.00357384
7Mismatch repair_Homo sapiens_hsa034302.99182662
8DNA replication_Homo sapiens_hsa030302.97334596
9Homologous recombination_Homo sapiens_hsa034402.86960735
10RNA polymerase_Homo sapiens_hsa030202.76756550
11Vitamin B6 metabolism_Homo sapiens_hsa007502.73159069
12Fanconi anemia pathway_Homo sapiens_hsa034602.68885058
13Base excision repair_Homo sapiens_hsa034102.55276820
14Taste transduction_Homo sapiens_hsa047422.46534698
15Nucleotide excision repair_Homo sapiens_hsa034202.36835808
16Ovarian steroidogenesis_Homo sapiens_hsa049132.19314326
17p53 signaling pathway_Homo sapiens_hsa041152.19098580
18Oocyte meiosis_Homo sapiens_hsa041142.11158651
19Caffeine metabolism_Homo sapiens_hsa002322.10565782
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.05566298
21Non-homologous end-joining_Homo sapiens_hsa034502.02674405
22mRNA surveillance pathway_Homo sapiens_hsa030151.88901531
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79494526
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68441139
25Spliceosome_Homo sapiens_hsa030401.67180782
26Linoleic acid metabolism_Homo sapiens_hsa005911.64084494
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57772411
28TGF-beta signaling pathway_Homo sapiens_hsa043501.52624841
29Circadian rhythm_Homo sapiens_hsa047101.51491437
30Dorso-ventral axis formation_Homo sapiens_hsa043201.48388211
31One carbon pool by folate_Homo sapiens_hsa006701.40077554
32MicroRNAs in cancer_Homo sapiens_hsa052061.39758417
33ABC transporters_Homo sapiens_hsa020101.38093833
34Pyrimidine metabolism_Homo sapiens_hsa002401.37259305
35Hippo signaling pathway_Homo sapiens_hsa043901.34386022
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34306483
37Pancreatic cancer_Homo sapiens_hsa052121.28674079
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27743096
39mTOR signaling pathway_Homo sapiens_hsa041501.23462850
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.22222642
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16327854
42Ether lipid metabolism_Homo sapiens_hsa005651.15449461
43Olfactory transduction_Homo sapiens_hsa047401.11621571
44Serotonergic synapse_Homo sapiens_hsa047261.11317928
45Colorectal cancer_Homo sapiens_hsa052101.07943503
46Thyroid cancer_Homo sapiens_hsa052161.06996894
47Huntingtons disease_Homo sapiens_hsa050161.04323731
48Adherens junction_Homo sapiens_hsa045200.99602923
49Gap junction_Homo sapiens_hsa045400.90566670
50Purine metabolism_Homo sapiens_hsa002300.87784029
51Folate biosynthesis_Homo sapiens_hsa007900.85030665
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.84853864
53Morphine addiction_Homo sapiens_hsa050320.84746447
54Choline metabolism in cancer_Homo sapiens_hsa052310.84195292
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82218447
56Nicotine addiction_Homo sapiens_hsa050330.81521569
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.80802801
58Renal cell carcinoma_Homo sapiens_hsa052110.79852969
59Notch signaling pathway_Homo sapiens_hsa043300.78225666
60Epstein-Barr virus infection_Homo sapiens_hsa051690.73345383
61Small cell lung cancer_Homo sapiens_hsa052220.72400619
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71225595
63GnRH signaling pathway_Homo sapiens_hsa049120.70290537
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69417372
65Bladder cancer_Homo sapiens_hsa052190.68814013
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68000407
67HTLV-I infection_Homo sapiens_hsa051660.67717836
68VEGF signaling pathway_Homo sapiens_hsa043700.66517748
69FoxO signaling pathway_Homo sapiens_hsa040680.64604207
70Endometrial cancer_Homo sapiens_hsa052130.64484252
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63781736
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63333883
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62122154
74Hedgehog signaling pathway_Homo sapiens_hsa043400.61362594
75Sphingolipid metabolism_Homo sapiens_hsa006000.61061959
76Tight junction_Homo sapiens_hsa045300.60612986
77Histidine metabolism_Homo sapiens_hsa003400.59959492
78Viral carcinogenesis_Homo sapiens_hsa052030.59273651
79Herpes simplex infection_Homo sapiens_hsa051680.56876479
80Lysine degradation_Homo sapiens_hsa003100.56151931
81Prolactin signaling pathway_Homo sapiens_hsa049170.54920572
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54867258
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51869699
84Proteasome_Homo sapiens_hsa030500.51516366
85Regulation of autophagy_Homo sapiens_hsa041400.50843935
86Inositol phosphate metabolism_Homo sapiens_hsa005620.50723053
87Biosynthesis of amino acids_Homo sapiens_hsa012300.50652012
88Salivary secretion_Homo sapiens_hsa049700.50339202
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50265895
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.49658952
91Basal cell carcinoma_Homo sapiens_hsa052170.48148945
92N-Glycan biosynthesis_Homo sapiens_hsa005100.47911524
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47614278
94Sulfur metabolism_Homo sapiens_hsa009200.46670779
95Prostate cancer_Homo sapiens_hsa052150.46560930
96Cardiac muscle contraction_Homo sapiens_hsa042600.45793228
97cAMP signaling pathway_Homo sapiens_hsa040240.45241131
98Non-small cell lung cancer_Homo sapiens_hsa052230.44477197
99Arachidonic acid metabolism_Homo sapiens_hsa005900.42187359
100Pathways in cancer_Homo sapiens_hsa052000.41632829
101Fatty acid biosynthesis_Homo sapiens_hsa000610.41002107
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40810794
103Rap1 signaling pathway_Homo sapiens_hsa040150.40267083
104Dilated cardiomyopathy_Homo sapiens_hsa054140.40221586
105Wnt signaling pathway_Homo sapiens_hsa043100.38773965
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38283559
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38243187
108Insulin secretion_Homo sapiens_hsa049110.38140818
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38131855
110Ras signaling pathway_Homo sapiens_hsa040140.37931242
111Chronic myeloid leukemia_Homo sapiens_hsa052200.37799537
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37225175
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37150771
114GABAergic synapse_Homo sapiens_hsa047270.36686558
115Steroid biosynthesis_Homo sapiens_hsa001000.34060629
116Melanoma_Homo sapiens_hsa052180.33144177
117Alcoholism_Homo sapiens_hsa050340.33059077
118Glutamatergic synapse_Homo sapiens_hsa047240.32329024
119Vitamin digestion and absorption_Homo sapiens_hsa049770.31758090
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.30537527
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30387098
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.30355699
123Arginine and proline metabolism_Homo sapiens_hsa003300.30220739
124Calcium signaling pathway_Homo sapiens_hsa040200.29603083
125ECM-receptor interaction_Homo sapiens_hsa045120.29573828
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27683994
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27335228
128Circadian entrainment_Homo sapiens_hsa047130.26543864
129Cholinergic synapse_Homo sapiens_hsa047250.25453243
130Bile secretion_Homo sapiens_hsa049760.25110298
131Systemic lupus erythematosus_Homo sapiens_hsa053220.24476553
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24362499
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24033341
134Selenocompound metabolism_Homo sapiens_hsa004500.23586400
135Hepatitis B_Homo sapiens_hsa051610.23538375
136HIF-1 signaling pathway_Homo sapiens_hsa040660.23478446
137AMPK signaling pathway_Homo sapiens_hsa041520.23086763
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22952271
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21063494
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.18994092
141Apoptosis_Homo sapiens_hsa042100.18952689
142ErbB signaling pathway_Homo sapiens_hsa040120.17841366
143Shigellosis_Homo sapiens_hsa051310.17664306
144MAPK signaling pathway_Homo sapiens_hsa040100.16964162
145Pentose phosphate pathway_Homo sapiens_hsa000300.16697685
146Long-term depression_Homo sapiens_hsa047300.15458053
147Estrogen signaling pathway_Homo sapiens_hsa049150.14692472
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13303232

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