ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	6.58460375
2	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.94149585
3	multicellular organism reproduction (GO:0032504)	5.73897458
4	regulation of female gonad development (GO:2000194)	5.72584246
5	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.14048822
6	* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	42.5562495
7	male meiosis I (GO:0007141)	4.95663770
8	regulation of female receptivity (GO:0045924)	4.59265826
9	regulation of uterine smooth muscle contraction (GO:0070472)	4.59070237
10	aggressive behavior (GO:0002118)	4.36782054
11	protein kinase C signaling (GO:0070528)	4.30302046
12	meiosis I (GO:0007127)	4.23741136
13	regulation of DNA methylation (GO:0044030)	4.14635800
14	drinking behavior (GO:0042756)	4.08307207
15	positive regulation of humoral immune response (GO:0002922)	4.06720705
16	* regulation of retinoic acid receptor signaling pathway (GO:0048385)	35.3393449
17	regulation of penile erection (GO:0060405)	3.97817271
18	positive regulation of prostaglandin secretion (GO:0032308)	3.97559468
19	female mating behavior (GO:0060180)	3.94141832
20	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.93249063
21	response to acidic pH (GO:0010447)	3.90379092
22	glycine transport (GO:0015816)	3.87498399
23	reproduction (GO:0000003)	3.81138745
24	hyperosmotic salinity response (GO:0042538)	3.77331370
25	oocyte development (GO:0048599)	3.76854896
26	negative regulation of digestive system process (GO:0060457)	3.71232134
27	cellular response to pH (GO:0071467)	3.70681746
28	positive regulation of catecholamine secretion (GO:0033605)	3.66036570
29	sleep (GO:0030431)	3.61944751
30	negative regulation of reproductive process (GO:2000242)	3.53834049
31	positive regulation of digestive system process (GO:0060456)	3.52922125
32	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.36263972
33	regulation of prostaglandin secretion (GO:0032306)	3.35276897
34	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.18149020
35	mitotic chromosome condensation (GO:0007076)	3.10557360
36	binding of sperm to zona pellucida (GO:0007339)	3.07779026
37	maternal behavior (GO:0042711)	3.01191620
38	regulation of norepinephrine secretion (GO:0014061)	2.99701682
39	L-amino acid import (GO:0043092)	2.91812823
40	maturation of SSU-rRNA (GO:0030490)	2.89501998
41	positive regulation of reproductive process (GO:2000243)	2.88453062
42	male meiosis (GO:0007140)	2.78567737
43	rRNA modification (GO:0000154)	2.77087334
44	rRNA methylation (GO:0031167)	2.72898404
45	sperm-egg recognition (GO:0035036)	2.65602511
46	parental behavior (GO:0060746)	2.62953835
47	positive regulation of icosanoid secretion (GO:0032305)	2.62272100
48	single fertilization (GO:0007338)	2.52354902
49	meiotic cell cycle (GO:0051321)	2.49516724
50	N-terminal protein amino acid acetylation (GO:0006474)	2.46738017
51	histone H3-K9 demethylation (GO:0033169)	2.44116379
52	positive regulation of fatty acid transport (GO:2000193)	2.43112710
53	regulation of steroid hormone secretion (GO:2000831)	2.37880524
54	positive regulation of renal sodium excretion (GO:0035815)	2.30226807
55	chromosome condensation (GO:0030261)	2.27618335
56	response to food (GO:0032094)	2.25705450
57	transcription from mitochondrial promoter (GO:0006390)	2.22815276
58	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.22064227
59	telomere maintenance via telomere lengthening (GO:0010833)	2.19967398
60	mitotic metaphase plate congression (GO:0007080)	2.12919078
61	cell-cell recognition (GO:0009988)	2.11904639
62	fertilization (GO:0009566)	2.11890550
63	regulation of reproductive process (GO:2000241)	2.11361302
64	regulation of G0 to G1 transition (GO:0070316)	2.10803782
65	snRNA transcription (GO:0009301)	2.10578863
66	amino acid import (GO:0043090)	2.10553240
67	ventricular cardiac muscle cell development (GO:0055015)	2.08907433
68	meiotic nuclear division (GO:0007126)	2.08839020
69	grooming behavior (GO:0007625)	2.05128188
70	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.04561605
71	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.04337954
72	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.02785677
73	regulation of urine volume (GO:0035809)	2.00660753
74	regulation of spindle organization (GO:0090224)	2.00094177
75	skeletal muscle tissue regeneration (GO:0043403)	1.99940409
76	regulation of histone H3-K9 methylation (GO:0051570)	1.99127861
77	transcription elongation from RNA polymerase III promoter (GO:0006385)	1.98934599
78	termination of RNA polymerase III transcription (GO:0006386)	1.98934599
79	piRNA metabolic process (GO:0034587)	1.98793590
80	translational termination (GO:0006415)	1.96711653
81	viral transcription (GO:0019083)	1.95878315
82	chaperone-mediated protein transport (GO:0072321)	1.95553124
83	sensory perception of taste (GO:0050909)	1.94770416
84	chaperone mediated protein folding requiring cofactor (GO:0051085)	1.94179241
85	regulation of mitotic spindle organization (GO:0060236)	1.93648652
86	protein K6-linked ubiquitination (GO:0085020)	1.92997133
87	female gamete generation (GO:0007292)	1.90666886
88	phosphorelay signal transduction system (GO:0000160)	1.89290680
89	regulation of icosanoid secretion (GO:0032303)	1.88689673
90	regulation of cell cycle G2/M phase transition (GO:1902749)	1.88388415
91	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	1.87887623
92	autophagic vacuole assembly (GO:0000045)	1.85298977
93	DNA packaging (GO:0006323)	1.82710723
94	response to prostaglandin E (GO:0034695)	1.82687377
95	metaphase plate congression (GO:0051310)	1.81116155
96	positive regulation of smooth muscle contraction (GO:0045987)	1.79200067
97	regulation of exit from mitosis (GO:0007096)	1.78414094
98	meiotic cell cycle process (GO:1903046)	1.77663080
99	regulation of sensory perception of pain (GO:0051930)	1.77125499
100	regulation of sensory perception (GO:0051931)	1.77125499

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.90771303
2	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	5.17225752
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	5.17225752
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	5.17225752
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.85664134
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.66462414
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.63880450
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.03323768
9	ZNF274_21170338_ChIP-Seq_K562_Hela	3.79152698
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.56699861
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.99559629
12	* ETV1_20927104_ChIP-Seq_GIST48_Human	2.79468474
13	* RBPJ_21746931_ChIP-Seq_IB4_Human	2.65802709
14	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.65575667
15	* TBL1_22424771_ChIP-Seq_293T_Human	2.46413253
16	* NFYB_21822215_ChIP-Seq_K562_Human	2.44817247
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41165108
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.28025415
19	* PHF8_20622853_ChIP-Seq_HELA_Human	2.21190335
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21099011
21	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.20948336
22	MYC_18940864_ChIP-ChIP_HL60_Human	2.14787164
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.06885909
24	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	2.04856647
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98005108
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95256141
27	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.92007307
28	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.86337344
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.79410298
30	NANOG_20526341_ChIP-Seq_ESCs_Human	1.77734661
31	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.75167007
32	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74409237
33	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.69187843
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.57263433
35	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.52924635
36	* NFYA_21822215_ChIP-Seq_K562_Human	1.46265890
37	STAT1_20625510_ChIP-Seq_HELA_Human	1.46198849
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42780503
39	RAC3_21632823_ChIP-Seq_H3396_Human	1.40804563
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38977480
41	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.38171103
42	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.36302466
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35350644
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30250546
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29248585
46	E2F7_22180533_ChIP-Seq_HELA_Human	1.24685053
47	SOX2_21211035_ChIP-Seq_LN229_Human	1.22888370
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.21263545
49	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.20750178
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17570808
51	CTCF_20526341_ChIP-Seq_ESCs_Human	1.17206606
52	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.15497144
53	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.15365400
54	AR_21909140_ChIP-Seq_LNCAP_Human	1.13307515
55	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.12574384
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10878982
57	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09952325
58	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09945500
59	E2F1_20622854_ChIP-Seq_HELA_Human	1.08572937
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.07576755
61	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.07278651
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.07067480
63	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.99754031
64	VDR_22108803_ChIP-Seq_LS180_Human	0.97787620
65	GBX2_23144817_ChIP-Seq_PC3_Human	0.97734839
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96792255
67	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95788662
68	NCOR_22424771_ChIP-Seq_293T_Human	0.94807865
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93957079
70	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91510482
71	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90495262
72	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88124681
73	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87084758
74	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.86567278
75	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85928904
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84204232
77	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.82386905
78	FOXP3_21729870_ChIP-Seq_TREG_Human	0.81483310
79	SMAD4_21799915_ChIP-Seq_A2780_Human	0.81354107
80	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.80929617
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.80595658
82	ELK1_19687146_ChIP-ChIP_HELA_Human	0.80127432
83	RNF2_27304074_Chip-Seq_NSC_Mouse	0.78725762
84	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.78577057
85	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.78188347
86	TTF2_22483619_ChIP-Seq_HELA_Human	0.78030914
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.75322878
88	KLF4_19829295_ChIP-Seq_ESCs_Human	0.75232326
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.74398909
90	CTCF_21964334_Chip-Seq_Bcells_Human	0.73208956
91	GATA3_26560356_Chip-Seq_TH1_Human	0.71686539
92	GATA3_26560356_Chip-Seq_TH2_Human	0.70281090
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.69432266
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.69415242
95	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.66846824
96	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.66372890
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.65922526
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.65922526
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.65700743
100	OCT4_19829295_ChIP-Seq_ESCs_Human	0.65128088

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.30416675
2	MP0003718_maternal_effect	5.28290061
3	MP0009379_abnormal_foot_pigmentation	4.18209813
4	MP0001986_abnormal_taste_sensitivity	4.17517528
5	MP0005423_abnormal_somatic_nervous	3.96397721
6	MP0005394_taste/olfaction_phenotype	3.24252098
7	MP0005499_abnormal_olfactory_system	3.24252098
8	MP0005410_abnormal_fertilization	3.09774711
9	MP0006276_abnormal_autonomic_nervous	2.78165608
10	MP0003693_abnormal_embryo_hatching	2.62025367
11	MP0009840_abnormal_foam_cell	2.45297202
12	MP0008789_abnormal_olfactory_epithelium	2.43259118
13	MP0002160_abnormal_reproductive_system	2.39335627
14	MP0001929_abnormal_gametogenesis	2.37245794
15	MP0002127_abnormal_cardiovascular_syste	2.34495250
16	MP0008877_abnormal_DNA_methylation	2.29773687
17	MP0002210_abnormal_sex_determination	2.22805803
18	MP0005360_urolithiasis	2.13657685
19	MP0002138_abnormal_hepatobiliary_system	2.13166032
20	MP0005395_other_phenotype	2.12238925
21	MP0005647_abnormal_sex_gland	2.09019738
22	MP0010307_abnormal_tumor_latency	2.05206926
23	MP0008057_abnormal_DNA_replication	2.03756000
24	MP0003646_muscle_fatigue	2.00585034
25	MP0003136_yellow_coat_color	1.96669094
26	MP0003699_abnormal_female_reproductive	1.94177360
27	MP0005389_reproductive_system_phenotype	1.93547255
28	MP0003195_calcinosis	1.85099032
29	MP0001881_abnormal_mammary_gland	1.81172834
30	MP0000372_irregular_coat_pigmentation	1.79388581
31	MP0002277_abnormal_respiratory_mucosa	1.75100114
32	MP0003077_abnormal_cell_cycle	1.73178110
33	MP0005646_abnormal_pituitary_gland	1.68391388
34	MP0010030_abnormal_orbit_morphology	1.64653132
35	MP0003950_abnormal_plasma_membrane	1.63686147
36	MP0000653_abnormal_sex_gland	1.59494702
37	MP0004957_abnormal_blastocyst_morpholog	1.58938189
38	MP0003111_abnormal_nucleus_morphology	1.58488185
39	MP0004142_abnormal_muscle_tone	1.53053140
40	MP0002161_abnormal_fertility/fecundity	1.52606591
41	MP0003698_abnormal_male_reproductive	1.41538875
42	MP0003879_abnormal_hair_cell	1.39705926
43	MP0009333_abnormal_splenocyte_physiolog	1.38048800
44	MP0001502_abnormal_circadian_rhythm	1.37049033
45	MP0010094_abnormal_chromosome_stability	1.36117932
46	MP0002736_abnormal_nociception_after	1.34915904
47	MP0008058_abnormal_DNA_repair	1.34658028
48	MP0002254_reproductive_system_inflammat	1.26966536
49	MP0001968_abnormal_touch/_nociception	1.23467498
50	MP0001145_abnormal_male_reproductive	1.23198667
51	MP0001119_abnormal_female_reproductive	1.19652862
52	MP0010368_abnormal_lymphatic_system	1.13512278
53	MP0001672_abnormal_embryogenesis/_devel	1.05274997
54	MP0005380_embryogenesis_phenotype	1.05274997
55	MP0001293_anophthalmia	1.01601990
56	MP0001730_embryonic_growth_arrest	0.99029257
57	MP0002234_abnormal_pharynx_morphology	0.98705994
58	MP0008932_abnormal_embryonic_tissue	0.97140825
59	MP0005397_hematopoietic_system_phenotyp	0.94666005
60	MP0001545_abnormal_hematopoietic_system	0.94666005
61	MP0004233_abnormal_muscle_weight	0.94178399
62	MP0002233_abnormal_nose_morphology	0.94086575
63	MP0000631_abnormal_neuroendocrine_gland	0.91886249
64	MP0005551_abnormal_eye_electrophysiolog	0.90394338
65	MP0002139_abnormal_hepatobiliary_system	0.90265904
66	MP0001919_abnormal_reproductive_system	0.88864569
67	MP0003121_genomic_imprinting	0.88088803
68	MP0004215_abnormal_myocardial_fiber	0.86144494
69	MP0003890_abnormal_embryonic-extraembry	0.82463038
70	MP0000350_abnormal_cell_proliferation	0.80147413
71	MP0000627_abnormal_mammary_gland	0.80134019
72	MP0003119_abnormal_digestive_system	0.79726977
73	MP0003938_abnormal_ear_development	0.76997161
74	MP0005085_abnormal_gallbladder_physiolo	0.75470771
75	MP0002163_abnormal_gland_morphology	0.74242978
76	MP0003984_embryonic_growth_retardation	0.74092444
77	MP0001440_abnormal_grooming_behavior	0.70564622
78	MP0001324_abnormal_eye_pigmentation	0.70438110
79	MP0002269_muscular_atrophy	0.70334258
80	MP0002095_abnormal_skin_pigmentation	0.69970542
81	MP0002088_abnormal_embryonic_growth/wei	0.67719023
82	MP0001529_abnormal_vocalization	0.67282840
83	MP0003866_abnormal_defecation	0.66345782
84	MP0003936_abnormal_reproductive_system	0.65515181
85	MP0000049_abnormal_middle_ear	0.64650044
86	MP0004381_abnormal_hair_follicle	0.63965854
87	MP0005174_abnormal_tail_pigmentation	0.63472952
88	MP0001666_abnormal_nutrient_absorption	0.63299381
89	MP0005197_abnormal_uvea_morphology	0.61058436
90	MP0001984_abnormal_olfaction	0.59728915
91	MP0002272_abnormal_nervous_system	0.58954923
92	MP0002873_normal_phenotype	0.56335969
93	MP0005645_abnormal_hypothalamus_physiol	0.56320752
94	MP0002169_no_abnormal_phenotype	0.55859769
95	MP0002102_abnormal_ear_morphology	0.54901595
96	MP0003186_abnormal_redox_activity	0.54571882
97	MP0005075_abnormal_melanosome_morpholog	0.53845840
98	MP0001486_abnormal_startle_reflex	0.52369176
99	MP0000762_abnormal_tongue_morphology	0.52140148
100	MP0000569_abnormal_digit_pigmentation	0.50861884

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	8.00910288
2	Malnutrition (HP:0004395)	6.97346484
3	Premature ovarian failure (HP:0008209)	5.20044562
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.68824323
5	Hypoplasia of the fovea (HP:0007750)	4.68824323
6	Aplasia/hypoplasia of the uterus (HP:0008684)	4.33527876
7	Rhinitis (HP:0012384)	4.25951784
8	Hypercortisolism (HP:0001578)	4.18863284
9	Infertility (HP:0000789)	3.98793870
10	Carpal bone hypoplasia (HP:0001498)	3.86379386
11	Anterior segment dysgenesis (HP:0007700)	3.77567054
12	Myokymia (HP:0002411)	3.72446876
13	Birth length less than 3rd percentile (HP:0003561)	3.70798406
14	Abnormality of the fovea (HP:0000493)	3.62305723
15	Hypoplasia of the uterus (HP:0000013)	3.61313174
16	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.55562144
17	Steatorrhea (HP:0002570)	3.51694217
18	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.25896883
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.20186703
20	Attenuation of retinal blood vessels (HP:0007843)	3.20138574
21	Sensory axonal neuropathy (HP:0003390)	3.19263744
22	Muscle stiffness (HP:0003552)	3.13871427
23	Periauricular skin pits (HP:0100277)	3.13326818
24	Preauricular pit (HP:0004467)	3.13326818
25	Abnormality of the septum pellucidum (HP:0007375)	3.10048820
26	Hypophosphatemic rickets (HP:0004912)	3.02736694
27	Aplasia/Hypoplasia of the macula (HP:0008059)	3.00804537
28	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.91555789
29	Constricted visual fields (HP:0001133)	2.89757155
30	Impulsivity (HP:0100710)	2.86383381
31	Abdominal situs inversus (HP:0003363)	2.81779482
32	Abnormality of abdominal situs (HP:0011620)	2.81779482
33	Fat malabsorption (HP:0002630)	2.81244281
34	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.76143107
35	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.75716962
36	Short tibia (HP:0005736)	2.70928158
37	Adrenal overactivity (HP:0002717)	2.60123762
38	Microretrognathia (HP:0000308)	2.56151163
39	Facial cleft (HP:0002006)	2.55738299
40	Abnormal ciliary motility (HP:0012262)	2.54531333
41	Hypergonadotropic hypogonadism (HP:0000815)	2.53828879
42	Septo-optic dysplasia (HP:0100842)	2.52443098
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.50359676
44	Multiple enchondromatosis (HP:0005701)	2.48451542
45	Dysphonia (HP:0001618)	2.45562700
46	Limb dystonia (HP:0002451)	2.45158635
47	Absent septum pellucidum (HP:0001331)	2.44593576
48	Congenital ichthyosiform erythroderma (HP:0007431)	2.36715560
49	Aplasia/hypoplasia of the humerus (HP:0006507)	2.36461036
50	Cone-rod dystrophy (HP:0000548)	2.33650110
51	Pendular nystagmus (HP:0012043)	2.33054638
52	Congenital sensorineural hearing impairment (HP:0008527)	2.31790408
53	Retinal atrophy (HP:0001105)	2.31106364
54	Central scotoma (HP:0000603)	2.28853931
55	Cortical visual impairment (HP:0100704)	2.22493820
56	Cleft eyelid (HP:0000625)	2.22437427
57	Reticulocytopenia (HP:0001896)	2.21924664
58	Skin pits (HP:0100276)	2.17137609
59	Osteomalacia (HP:0002749)	2.15730258
60	Aplasia of the musculature (HP:0100854)	2.15723207
61	Gaze-evoked nystagmus (HP:0000640)	2.13952655
62	Abnormality of the pubic bones (HP:0003172)	2.13217915
63	Esotropia (HP:0000565)	2.12335821
64	Macular degeneration (HP:0000608)	2.12248247
65	Absent radius (HP:0003974)	2.11620005
66	Abnormality of cells of the erythroid lineage (HP:0012130)	2.10836902
67	Fibular aplasia (HP:0002990)	2.03595744
68	Patent foramen ovale (HP:0001655)	2.02891866
69	Abnormal respiratory epithelium morphology (HP:0012253)	2.00346525
70	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00346525
71	Decreased central vision (HP:0007663)	1.99736160
72	Glossoptosis (HP:0000162)	1.99331496
73	Nausea (HP:0002018)	1.99168904
74	Absent forearm bone (HP:0003953)	1.98796754
75	Aplasia involving forearm bones (HP:0009822)	1.98796754
76	Midline defect of the nose (HP:0004122)	1.98260309
77	Progressive cerebellar ataxia (HP:0002073)	1.97665607
78	Anhidrosis (HP:0000970)	1.96804486
79	Decreased circulating renin level (HP:0003351)	1.95879296
80	Fused cervical vertebrae (HP:0002949)	1.95420638
81	Atresia of the external auditory canal (HP:0000413)	1.94085901
82	Clumsiness (HP:0002312)	1.93750534
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90800254
84	Selective tooth agenesis (HP:0001592)	1.90501997
85	Progressive sensorineural hearing impairment (HP:0000408)	1.89958657
86	Abnormal number of erythroid precursors (HP:0012131)	1.89785990
87	Delayed CNS myelination (HP:0002188)	1.87730575
88	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87577777
89	Absent thumb (HP:0009777)	1.87261188
90	Cranial hyperostosis (HP:0004437)	1.86361582
91	Concave nail (HP:0001598)	1.86339923
92	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.85479718
93	Impaired proprioception (HP:0010831)	1.84672045
94	Progressive hearing impairment (HP:0001730)	1.84492773
95	Pancreatic cysts (HP:0001737)	1.83198337
96	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.81313865
97	Absent/shortened dynein arms (HP:0200106)	1.80512696
98	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80512696
99	Progressive inability to walk (HP:0002505)	1.79220592
100	Chronic sinusitis (HP:0011109)	1.78527596

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.93397007
2	BUB1	4.15336064
3	CDK19	4.02733031
4	LATS2	3.99629901
5	SRPK1	3.47824215
6	NEK6	3.44362127
7	BRSK2	3.11470128
8	TRIM28	3.09664676
9	STK16	2.69496446
10	FRK	2.45412950
11	BRSK1	2.36092588
12	MAP3K9	2.16577205
13	ZAK	2.15596646
14	MARK3	1.89124124
15	PLK1	1.80934536
16	EIF2AK3	1.65113074
17	TLK1	1.61603854
18	ACVR1B	1.59604550
19	MELK	1.51562862
20	WNK1	1.51290321
21	MAP3K5	1.50015822
22	NEK2	1.43521051
23	PRKCI	1.41777622
24	TAOK3	1.39507684
25	PKN1	1.39454201
26	CDK7	1.39320718
27	NTRK3	1.38261717
28	AURKB	1.35837103
29	PLK3	1.28930890
30	AURKA	1.28633413
31	STK3	1.28143401
32	NME1	1.17377098
33	DYRK3	1.15927293
34	GSK3A	1.14060007
35	INSRR	1.08542790
36	STK24	0.97701716
37	CHEK1	0.97646817
38	WNK3	0.97547956
39	CDK9	0.96357143
40	CSNK1E	0.92446008
41	CDC7	0.92400464
42	PIM1	0.90053704
43	LRRK2	0.89614165
44	KDR	0.89422043
45	PDK2	0.86779815
46	CHEK2	0.85089317
47	ADRBK2	0.74392681
48	PIM2	0.68718161
49	PBK	0.66353093
50	VRK1	0.64295131
51	PAK1	0.64215046
52	CSNK2A1	0.62919478
53	PIK3CG	0.61759789
54	CSNK2A2	0.60904775
55	CDK2	0.58649812
56	BMPR1B	0.58352471
57	AKT2	0.56484122
58	WEE1	0.56285879
59	PLK4	0.55013309
60	RAF1	0.53917961
61	TTK	0.51471131
62	ATR	0.51299120
63	LATS1	0.50736565
64	TNK2	0.46619247
65	STK4	0.45937446
66	CDK1	0.45577270
67	VRK2	0.44300109
68	PAK2	0.43549705
69	CDK12	0.42819701
70	NUAK1	0.42790441
71	CAMK1	0.40711859
72	MTOR	0.40275543
73	TGFBR1	0.40235334
74	PDK1	0.38517949
75	MAPK11	0.38383960
76	ADRBK1	0.37333560
77	PRKG1	0.36833321
78	ARAF	0.36798635
79	GRK5	0.35669061
80	CSNK1D	0.35190133
81	DMPK	0.31465597
82	MAP3K13	0.30097681
83	GSK3B	0.29792642
84	STK38L	0.29582157
85	CDK11A	0.29492637
86	OXSR1	0.27934873
87	PRKCG	0.26655180
88	ATM	0.25517953
89	MAPK13	0.25105727
90	GRK1	0.24763337
91	PRKCE	0.24329581
92	MAPK1	0.23414053
93	CSNK1A1	0.20458581
94	PRKACA	0.19524058
95	CSNK1G1	0.18968609
96	NTRK2	0.18445998
97	CAMK2A	0.17382033
98	STK39	0.16876364
99	PRKD1	0.16747904
100	MAPK9	0.16737021

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	6.42258470
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.92196132
3	Ribosome_Homo sapiens_hsa03010	3.78569628
4	RNA polymerase_Homo sapiens_hsa03020	3.48985866
5	mRNA surveillance pathway_Homo sapiens_hsa03015	3.26062856
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.16192235
7	Taste transduction_Homo sapiens_hsa04742	3.12670498
8	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.05879740
9	Cell cycle_Homo sapiens_hsa04110	3.01894734
10	Regulation of autophagy_Homo sapiens_hsa04140	2.84776372
11	Folate biosynthesis_Homo sapiens_hsa00790	2.73078067
12	Oocyte meiosis_Homo sapiens_hsa04114	2.31733658
13	RNA transport_Homo sapiens_hsa03013	2.24312213
14	p53 signaling pathway_Homo sapiens_hsa04115	2.24147910
15	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.19710550
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00222136
17	Spliceosome_Homo sapiens_hsa03040	1.90507077
18	Olfactory transduction_Homo sapiens_hsa04740	1.60014070
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.54813715
20	ABC transporters_Homo sapiens_hsa02010	1.49296920
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27668952
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21216711
23	Sulfur metabolism_Homo sapiens_hsa00920	1.11345903
24	Homologous recombination_Homo sapiens_hsa03440	1.11145874
25	Serotonergic synapse_Homo sapiens_hsa04726	1.06892600
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04975629
27	Viral carcinogenesis_Homo sapiens_hsa05203	1.02623306
28	RNA degradation_Homo sapiens_hsa03018	1.02380540
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01317332
30	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96299955
31	Mismatch repair_Homo sapiens_hsa03430	0.96180579
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.94536700
33	Caffeine metabolism_Homo sapiens_hsa00232	0.94504920
34	Huntingtons disease_Homo sapiens_hsa05016	0.94471441
35	Base excision repair_Homo sapiens_hsa03410	0.92114589
36	Nicotine addiction_Homo sapiens_hsa05033	0.91764031
37	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87569929
38	Morphine addiction_Homo sapiens_hsa05032	0.84280854
39	Nucleotide excision repair_Homo sapiens_hsa03420	0.80796427
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80310679
41	Purine metabolism_Homo sapiens_hsa00230	0.74518947
42	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.72300734
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70673604
44	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.69814516
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68912176
46	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64950165
47	Fatty acid elongation_Homo sapiens_hsa00062	0.60708522
48	MicroRNAs in cancer_Homo sapiens_hsa05206	0.60191430
49	DNA replication_Homo sapiens_hsa03030	0.59748108
50	Histidine metabolism_Homo sapiens_hsa00340	0.56624866
51	Insulin secretion_Homo sapiens_hsa04911	0.55499563
52	GABAergic synapse_Homo sapiens_hsa04727	0.52862955
53	Herpes simplex infection_Homo sapiens_hsa05168	0.52744701
54	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.51932315
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.50767349
56	Bile secretion_Homo sapiens_hsa04976	0.48373626
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.47261749
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41945512
59	Parkinsons disease_Homo sapiens_hsa05012	0.40764016
60	Wnt signaling pathway_Homo sapiens_hsa04310	0.40359335
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.37529077
62	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37314572
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36714767
64	Protein digestion and absorption_Homo sapiens_hsa04974	0.35888178
65	Mineral absorption_Homo sapiens_hsa04978	0.33786546
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.33746263
67	Small cell lung cancer_Homo sapiens_hsa05222	0.33532521
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.33329936
69	Hepatitis B_Homo sapiens_hsa05161	0.32968089
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31807249
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30521997
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30172557
73	Circadian entrainment_Homo sapiens_hsa04713	0.29737637
74	Phototransduction_Homo sapiens_hsa04744	0.28365001
75	Retinol metabolism_Homo sapiens_hsa00830	0.28271461
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27315166
77	AMPK signaling pathway_Homo sapiens_hsa04152	0.27233915
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.25301901
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24163504
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23944235
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.22972838
82	Salivary secretion_Homo sapiens_hsa04970	0.18547981
83	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.17965783
84	Pancreatic secretion_Homo sapiens_hsa04972	0.17895091
85	Amphetamine addiction_Homo sapiens_hsa05031	0.17037327
86	Long-term depression_Homo sapiens_hsa04730	0.14960323
87	Acute myeloid leukemia_Homo sapiens_hsa05221	0.14871544
88	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.14201228
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.13369991
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.13129992
91	Gastric acid secretion_Homo sapiens_hsa04971	0.12462299
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.10852172
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.10732965
94	FoxO signaling pathway_Homo sapiens_hsa04068	0.10691866
95	Gap junction_Homo sapiens_hsa04540	0.10143934
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.10045694
97	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.10027541
98	Alcoholism_Homo sapiens_hsa05034	0.09807046
99	Metabolic pathways_Homo sapiens_hsa01100	0.08849535
100	Cholinergic synapse_Homo sapiens_hsa04725	0.08658646

PRAMEF14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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