ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	5.87112413
2	regulation of acrosome reaction (GO:0060046)	5.30388079
3	meiosis I (GO:0007127)	5.07559814
4	* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	42.7421430
5	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.45306386
6	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.33663863
7	regulation of DNA methylation (GO:0044030)	4.31291657
8	multicellular organism reproduction (GO:0032504)	4.21745153
9	regulation of female gonad development (GO:2000194)	4.21419327
10	* regulation of retinoic acid receptor signaling pathway (GO:0048385)	35.5557227
11	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.88914987
12	regulation of female receptivity (GO:0045924)	3.69437627
13	mitotic chromosome condensation (GO:0007076)	3.63792432
14	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.63590957
15	aggressive behavior (GO:0002118)	3.62467551
16	drinking behavior (GO:0042756)	3.55667908
17	regulation of uterine smooth muscle contraction (GO:0070472)	3.41399994
18	protein kinase C signaling (GO:0070528)	3.36401223
19	positive regulation of protein homooligomerization (GO:0032464)	3.32820792
20	hyperosmotic salinity response (GO:0042538)	3.32432686
21	regulation of penile erection (GO:0060405)	3.32246108
22	positive regulation of humoral immune response (GO:0002922)	3.31469638
23	male meiosis (GO:0007140)	3.28667325
24	transcription from mitochondrial promoter (GO:0006390)	3.27274724
25	female mating behavior (GO:0060180)	3.20329468
26	positive regulation of prostaglandin secretion (GO:0032308)	3.16991943
27	negative regulation of digestive system process (GO:0060457)	3.13522979
28	oocyte development (GO:0048599)	3.12376844
29	mitotic metaphase plate congression (GO:0007080)	3.05523339
30	positive regulation of digestive system process (GO:0060456)	3.05164500
31	negative regulation of reproductive process (GO:2000242)	3.05144467
32	response to acidic pH (GO:0010447)	3.02508472
33	positive regulation of catecholamine secretion (GO:0033605)	2.97160508
34	regulation of mitotic spindle organization (GO:0060236)	2.97115345
35	rRNA modification (GO:0000154)	2.90469560
36	maturation of SSU-rRNA (GO:0030490)	2.89916551
37	sleep (GO:0030431)	2.89185915
38	regulation of spindle organization (GO:0090224)	2.88507448
39	reproduction (GO:0000003)	2.79861576
40	cellular response to pH (GO:0071467)	2.78404313
41	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.73944132
42	ribosome assembly (GO:0042255)	2.72027520
43	autophagic vacuole assembly (GO:0000045)	2.68806581
44	regulation of prostaglandin secretion (GO:0032306)	2.67012364
45	glycine transport (GO:0015816)	2.66239501
46	ventricular cardiac muscle cell development (GO:0055015)	2.61166953
47	rRNA methylation (GO:0031167)	2.55607867
48	telomere maintenance via telomere lengthening (GO:0010833)	2.52161449
49	chaperone-mediated protein transport (GO:0072321)	2.49481131
50	binding of sperm to zona pellucida (GO:0007339)	2.47400899
51	chromosome condensation (GO:0030261)	2.42952408
52	meiotic cell cycle (GO:0051321)	2.42672472
53	N-terminal protein amino acid acetylation (GO:0006474)	2.39623230
54	metaphase plate congression (GO:0051310)	2.39241221
55	meiotic nuclear division (GO:0007126)	2.38267714
56	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.35382435
57	termination of RNA polymerase III transcription (GO:0006386)	2.35382435
58	positive regulation of reproductive process (GO:2000243)	2.35345473
59	regulation of norepinephrine secretion (GO:0014061)	2.35128181
60	maternal behavior (GO:0042711)	2.34333313
61	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.32818587
62	regulation of G0 to G1 transition (GO:0070316)	2.31486378
63	protein localization to chromosome, centromeric region (GO:0071459)	2.27078582
64	regulation of histone H3-K9 methylation (GO:0051570)	2.26008086
65	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.24106664
66	histone H3-K9 demethylation (GO:0033169)	2.21306296
67	snRNA transcription (GO:0009301)	2.19228690
68	regulation of RNA export from nucleus (GO:0046831)	2.18265628
69	regulation of exit from mitosis (GO:0007096)	2.17600124
70	protein K6-linked ubiquitination (GO:0085020)	2.17573773
71	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.14344213
72	response to food (GO:0032094)	2.14323717
73	attachment of spindle microtubules to kinetochore (GO:0008608)	2.09920638
74	meiotic cell cycle process (GO:1903046)	2.07980661
75	oocyte maturation (GO:0001556)	2.07755959
76	positive regulation of chromosome segregation (GO:0051984)	2.07448159
77	positive regulation of icosanoid secretion (GO:0032305)	2.04848594
78	parental behavior (GO:0060746)	2.04697566
79	polyamine biosynthetic process (GO:0006596)	2.03291736
80	muscle organ morphogenesis (GO:0048644)	1.98645981
81	DNA packaging (GO:0006323)	1.97544307
82	L-amino acid import (GO:0043092)	1.96221694
83	DNA replication initiation (GO:0006270)	1.96186842
84	regulation of cell cycle G2/M phase transition (GO:1902749)	1.96049371
85	skeletal muscle tissue regeneration (GO:0043403)	1.95367269
86	single fertilization (GO:0007338)	1.92548503
87	positive regulation of renal sodium excretion (GO:0035815)	1.91736545
88	positive regulation of histone H3-K4 methylation (GO:0051571)	1.91192439
89	sperm-egg recognition (GO:0035036)	1.90507652
90	ribosome biogenesis (GO:0042254)	1.89888917
91	positive regulation of cytokinesis (GO:0032467)	1.88591961
92	transcription elongation from RNA polymerase II promoter (GO:0006368)	1.87893227
93	negative regulation of RNA splicing (GO:0033119)	1.84528683
94	rRNA processing (GO:0006364)	1.84069824
95	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	1.83712318
96	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	1.82955803
97	histone mRNA metabolic process (GO:0008334)	1.82735122
98	positive regulation of fatty acid transport (GO:2000193)	1.81780222
99	transcription from RNA polymerase III promoter (GO:0006383)	1.81018702
100	androgen receptor signaling pathway (GO:0030521)	1.79743448

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	5.42385458
2	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	5.42385458
3	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	5.42385458
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.25064093
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.91344674
6	EZH2_22144423_ChIP-Seq_EOC_Human	4.83105693
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.55545458
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.14310024
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.80502057
10	E2F7_22180533_ChIP-Seq_HELA_Human	3.53829802
11	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.38997560
12	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30060344
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.95902562
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.95206532
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.90317994
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68386400
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.68189094
18	* ETV1_20927104_ChIP-Seq_GIST48_Human	2.61830202
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.47299343
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44428531
21	* RBPJ_21746931_ChIP-Seq_IB4_Human	2.44185931
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.43841424
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31582217
24	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.20501956
25	* TBL1_22424771_ChIP-Seq_293T_Human	2.15323622
26	* NFYB_21822215_ChIP-Seq_K562_Human	2.14626647
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.12745422
28	* PHF8_20622853_ChIP-Seq_HELA_Human	2.04847291
29	AR_21909140_ChIP-Seq_LNCAP_Human	2.00532186
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.96031017
31	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.93728936
32	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.83250092
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.82699383
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.80527782
35	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.77554951
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.70580235
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.62645820
38	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.56640376
39	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.55692856
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54432132
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.49342988
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.42062811
43	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.36902773
44	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.36187084
45	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.34439974
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.34360653
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30654952
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.27668613
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27657505
50	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.26889831
51	* NFYA_21822215_ChIP-Seq_K562_Human	1.25475968
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.25208904
53	XRN2_22483619_ChIP-Seq_HELA_Human	1.24060978
54	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.23667793
55	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.22342074
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.19522768
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17236125
58	STAT1_20625510_ChIP-Seq_HELA_Human	1.16725763
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13372289
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.12171973
61	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.11582985
62	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.05650407
63	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05119319
64	E2F1_20622854_ChIP-Seq_HELA_Human	0.98840504
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98119391
66	SOX2_21211035_ChIP-Seq_LN229_Human	0.97935209
67	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97051092
68	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95057633
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.94552490
70	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93827152
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92816673
72	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.92290763
73	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.88901750
74	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.87993467
75	TP53_22573176_ChIP-Seq_HFKS_Human	0.87441871
76	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86552512
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85954048
78	IRF1_19129219_ChIP-ChIP_H3396_Human	0.85237551
79	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.83250561
80	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.83225010
81	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.81994921
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.77370590
83	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.77357251
84	CIITA_25753668_ChIP-Seq_RAJI_Human	0.77068391
85	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.76833105
86	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.75387119
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.74891617
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.72443417
89	P53_21459846_ChIP-Seq_SAOS-2_Human	0.72021963
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.71688561
91	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.71310336
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.71235106
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.69692763
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.69174866
95	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.68257867
96	CTCF_21964334_Chip-Seq_Bcells_Human	0.68046393
97	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.67455066
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.65193440
99	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.64893722
100	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.64495680

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.67228615
2	MP0001986_abnormal_taste_sensitivity	5.36216763
3	MP0003718_maternal_effect	4.96575831
4	MP0005423_abnormal_somatic_nervous	4.77785283
5	MP0009379_abnormal_foot_pigmentation	3.46659568
6	MP0005394_taste/olfaction_phenotype	3.11536552
7	MP0005499_abnormal_olfactory_system	3.11536552
8	MP0003693_abnormal_embryo_hatching	2.97151758
9	MP0010307_abnormal_tumor_latency	2.87494369
10	MP0002127_abnormal_cardiovascular_syste	2.81989199
11	MP0005360_urolithiasis	2.39979066
12	MP0005410_abnormal_fertilization	2.34508563
13	MP0003111_abnormal_nucleus_morphology	2.32921552
14	MP0002277_abnormal_respiratory_mucosa	2.32851808
15	MP0002160_abnormal_reproductive_system	2.32574356
16	MP0004957_abnormal_blastocyst_morpholog	2.31026135
17	MP0002138_abnormal_hepatobiliary_system	2.30193853
18	MP0001929_abnormal_gametogenesis	2.29745580
19	MP0010030_abnormal_orbit_morphology	2.24002342
20	MP0003077_abnormal_cell_cycle	2.23724903
21	MP0002210_abnormal_sex_determination	2.21827043
22	MP0008877_abnormal_DNA_methylation	2.20819645
23	MP0009840_abnormal_foam_cell	2.18656925
24	MP0005395_other_phenotype	2.04539263
25	MP0008789_abnormal_olfactory_epithelium	2.00579458
26	MP0010094_abnormal_chromosome_stability	1.93482370
27	MP0001881_abnormal_mammary_gland	1.92360598
28	MP0008057_abnormal_DNA_replication	1.81055392
29	MP0006276_abnormal_autonomic_nervous	1.80526626
30	MP0009333_abnormal_splenocyte_physiolog	1.79355810
31	MP0008058_abnormal_DNA_repair	1.74783324
32	MP0003699_abnormal_female_reproductive	1.72333925
33	MP0005647_abnormal_sex_gland	1.69734790
34	MP0005389_reproductive_system_phenotype	1.66263091
35	MP0003195_calcinosis	1.61344225
36	MP0002254_reproductive_system_inflammat	1.55950856
37	MP0008260_abnormal_autophagy	1.55115178
38	MP0000653_abnormal_sex_gland	1.53502303
39	MP0002161_abnormal_fertility/fecundity	1.47766133
40	MP0003646_muscle_fatigue	1.47015520
41	MP0003136_yellow_coat_color	1.43926872
42	MP0001502_abnormal_circadian_rhythm	1.41622636
43	MP0005646_abnormal_pituitary_gland	1.40375217
44	MP0003698_abnormal_male_reproductive	1.32955007
45	MP0008932_abnormal_embryonic_tissue	1.28624078
46	MP0001145_abnormal_male_reproductive	1.27359287
47	MP0001672_abnormal_embryogenesis/_devel	1.26282631
48	MP0005380_embryogenesis_phenotype	1.26282631
49	MP0001293_anophthalmia	1.17815711
50	MP0010368_abnormal_lymphatic_system	1.17760953
51	MP0003121_genomic_imprinting	1.17640368
52	MP0002139_abnormal_hepatobiliary_system	1.15583141
53	MP0001730_embryonic_growth_arrest	1.15417475
54	MP0000350_abnormal_cell_proliferation	1.14838484
55	MP0003938_abnormal_ear_development	1.07119844
56	MP0001119_abnormal_female_reproductive	1.05986922
57	MP0002233_abnormal_nose_morphology	1.00089147
58	MP0001545_abnormal_hematopoietic_system	0.98759186
59	MP0005397_hematopoietic_system_phenotyp	0.98759186
60	MP0003984_embryonic_growth_retardation	0.97845533
61	MP0001666_abnormal_nutrient_absorption	0.96807772
62	MP0000372_irregular_coat_pigmentation	0.94264630
63	MP0000627_abnormal_mammary_gland	0.93689919
64	MP0000049_abnormal_middle_ear	0.93140938
65	MP0005451_abnormal_body_composition	0.92995014
66	MP0002088_abnormal_embryonic_growth/wei	0.91268323
67	MP0002234_abnormal_pharynx_morphology	0.89943623
68	MP0005085_abnormal_gallbladder_physiolo	0.86361038
69	MP0001697_abnormal_embryo_size	0.85330842
70	MP0006036_abnormal_mitochondrial_physio	0.82572630
71	MP0008995_early_reproductive_senescence	0.81918996
72	MP0004142_abnormal_muscle_tone	0.78526917
73	MP0003950_abnormal_plasma_membrane	0.77870575
74	MP0000762_abnormal_tongue_morphology	0.75457748
75	MP0004215_abnormal_myocardial_fiber	0.74714884
76	MP0003936_abnormal_reproductive_system	0.71870843
77	MP0003879_abnormal_hair_cell	0.70251184
78	MP0005197_abnormal_uvea_morphology	0.69198633
79	MP0004019_abnormal_vitamin_homeostasis	0.65472960
80	MP0000631_abnormal_neuroendocrine_gland	0.64685187
81	MP0002080_prenatal_lethality	0.63585601
82	MP0001919_abnormal_reproductive_system	0.63376824
83	MP0002873_normal_phenotype	0.61864604
84	MP0002169_no_abnormal_phenotype	0.61665374
85	MP0003890_abnormal_embryonic-extraembry	0.60555636
86	MP0002084_abnormal_developmental_patter	0.60175521
87	MP0002085_abnormal_embryonic_tissue	0.59225613
88	MP0001286_abnormal_eye_development	0.57062339
89	MP0003755_abnormal_palate_morphology	0.55912449
90	MP0001529_abnormal_vocalization	0.54546575
91	MP0000358_abnormal_cell_content/	0.54403229
92	MP0000428_abnormal_craniofacial_morphol	0.52251834
93	MP0002269_muscular_atrophy	0.50049681
94	MP0003186_abnormal_redox_activity	0.49972339
95	MP0003252_abnormal_bile_duct	0.49471616
96	MP0002751_abnormal_autonomic_nervous	0.49432059
97	MP0004381_abnormal_hair_follicle	0.48650165
98	MP0000750_abnormal_muscle_regeneration	0.47943913
99	MP0004233_abnormal_muscle_weight	0.46685566
100	MP0002086_abnormal_extraembryonic_tissu	0.44837105

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	8.44445832
2	Malnutrition (HP:0004395)	6.38712084
3	Premature ovarian failure (HP:0008209)	5.24779239
4	Aplasia/hypoplasia of the uterus (HP:0008684)	4.58438479
5	Hypercortisolism (HP:0001578)	4.42730801
6	Carpal bone hypoplasia (HP:0001498)	4.32063568
7	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.01370237
8	Patent foramen ovale (HP:0001655)	3.66675687
9	Preauricular pit (HP:0004467)	3.66086842
10	Periauricular skin pits (HP:0100277)	3.66086842
11	Abnormality of the septum pellucidum (HP:0007375)	3.63516588
12	Rhinitis (HP:0012384)	3.61515264
13	Hypoplasia of the uterus (HP:0000013)	3.59222359
14	Infertility (HP:0000789)	3.56484205
15	Birth length less than 3rd percentile (HP:0003561)	3.53229752
16	Hypophosphatemic rickets (HP:0004912)	3.52931175
17	Steatorrhea (HP:0002570)	3.46363759
18	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.31798694
19	Muscle stiffness (HP:0003552)	3.26385536
20	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.24088828
21	Hypoplasia of the fovea (HP:0007750)	3.24088828
22	Myokymia (HP:0002411)	3.18211058
23	Impulsivity (HP:0100710)	3.10742297
24	Sensory axonal neuropathy (HP:0003390)	3.04416551
25	Aplasia/hypoplasia of the humerus (HP:0006507)	3.02553092
26	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.00800753
27	Fat malabsorption (HP:0002630)	2.97725858
28	Short tibia (HP:0005736)	2.94220155
29	Abnormal pancreas size (HP:0012094)	2.92455859
30	Hypergonadotropic hypogonadism (HP:0000815)	2.89152326
31	Delayed CNS myelination (HP:0002188)	2.82885073
32	Septo-optic dysplasia (HP:0100842)	2.79477658
33	Absent septum pellucidum (HP:0001331)	2.79039681
34	Facial cleft (HP:0002006)	2.69923190
35	Anterior segment dysgenesis (HP:0007700)	2.69192994
36	Ureteral duplication (HP:0000073)	2.67808359
37	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.66671279
38	Reticulocytopenia (HP:0001896)	2.65139170
39	Congenital malformation of the right heart (HP:0011723)	2.63666148
40	Double outlet right ventricle (HP:0001719)	2.63666148
41	Dysphonia (HP:0001618)	2.60729415
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.59289273
43	Midline defect of the nose (HP:0004122)	2.54693758
44	Abdominal situs inversus (HP:0003363)	2.54125261
45	Abnormality of abdominal situs (HP:0011620)	2.54125261
46	Fused cervical vertebrae (HP:0002949)	2.52563224
47	Adrenal overactivity (HP:0002717)	2.52307062
48	Abnormality of the fetal cardiovascular system (HP:0010948)	2.48339592
49	Abnormal umbilical cord blood vessels (HP:0011403)	2.48339592
50	Single umbilical artery (HP:0001195)	2.48339592
51	Mitral stenosis (HP:0001718)	2.46932484
52	Multiple enchondromatosis (HP:0005701)	2.46398453
53	Meckel diverticulum (HP:0002245)	2.42985782
54	Abnormality of the fovea (HP:0000493)	2.41308181
55	Skin pits (HP:0100276)	2.40038689
56	Microretrognathia (HP:0000308)	2.39282872
57	Cleft eyelid (HP:0000625)	2.38385160
58	Progressive sensorineural hearing impairment (HP:0000408)	2.37108156
59	Glossoptosis (HP:0000162)	2.37070439
60	Abnormality of the ileum (HP:0001549)	2.35666536
61	Hypoglycemic seizures (HP:0002173)	2.31858776
62	Abnormality of the preputium (HP:0100587)	2.31620479
63	Constricted visual fields (HP:0001133)	2.30158978
64	Progressive hearing impairment (HP:0001730)	2.29528906
65	Sparse lateral eyebrow (HP:0005338)	2.29183843
66	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.25608170
67	Progressive muscle weakness (HP:0003323)	2.25263012
68	Absent radius (HP:0003974)	2.23932200
69	Limb dystonia (HP:0002451)	2.22446347
70	Attenuation of retinal blood vessels (HP:0007843)	2.20300744
71	Pendular nystagmus (HP:0012043)	2.20297908
72	Tetraparesis (HP:0002273)	2.15921194
73	Horseshoe kidney (HP:0000085)	2.15349070
74	Absent forearm bone (HP:0003953)	2.10284620
75	Aplasia involving forearm bones (HP:0009822)	2.10284620
76	Osteomalacia (HP:0002749)	2.10005692
77	Cortical visual impairment (HP:0100704)	2.09772532
78	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.09385914
79	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.06028398
80	Short 1st metacarpal (HP:0010034)	2.06028398
81	Atresia of the external auditory canal (HP:0000413)	2.05020785
82	Congenital ichthyosiform erythroderma (HP:0007431)	2.04734461
83	Abnormality of the aortic arch (HP:0012303)	2.04149044
84	Selective tooth agenesis (HP:0001592)	2.03878543
85	Testicular atrophy (HP:0000029)	2.02320947
86	Fibular aplasia (HP:0002990)	2.00629877
87	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.98333723
88	Hypoplastic scapulae (HP:0000882)	1.98333723
89	Chromsome breakage (HP:0040012)	1.96755070
90	Aplasia/Hypoplasia of the macula (HP:0008059)	1.96627663
91	Nausea (HP:0002018)	1.92750942
92	Stenosis of the external auditory canal (HP:0000402)	1.92738113
93	Abnormal number of incisors (HP:0011064)	1.91457519
94	Absent thumb (HP:0009777)	1.91230469
95	Impaired proprioception (HP:0010831)	1.90029464
96	Abnormality of cells of the erythroid lineage (HP:0012130)	1.85273515
97	Decreased central vision (HP:0007663)	1.84472711
98	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.83226235
99	Secondary amenorrhea (HP:0000869)	1.82398135
100	Azoospermia (HP:0000027)	1.82322255

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.99738236
2	LATS2	5.13400226
3	BUB1	4.63726709
4	SRPK1	4.43022135
5	TRIM28	3.17404467
6	CDK19	3.12942607
7	STK16	3.12623755
8	NEK6	2.99078788
9	BRSK2	2.60340909
10	BRSK1	2.48989666
11	PLK1	2.27201699
12	DYRK3	1.90669775
13	CDK9	1.81049173
14	PLK3	1.77014259
15	AURKB	1.76417049
16	MARK3	1.75822044
17	NEK2	1.63410219
18	EIF2AK3	1.59744406
19	CDC7	1.55917002
20	TAOK3	1.53416610
21	AURKA	1.51310844
22	CDK7	1.47918137
23	MAP3K9	1.45152367
24	ZAK	1.41417457
25	PRKCI	1.41320648
26	CDK12	1.41254789
27	PIM2	1.38752117
28	TLK1	1.32055042
29	GSK3A	1.31856325
30	WNK3	1.27724545
31	CHEK1	1.26143997
32	PDK2	1.20108429
33	CSNK1E	1.15163106
34	PBK	1.13365573
35	MAP3K5	1.10353934
36	WNK1	1.07080186
37	MELK	1.04638664
38	NTRK3	1.02037419
39	PKN1	1.00122497
40	RAF1	0.99583830
41	LRRK2	0.98414532
42	TTK	0.97808987
43	PIM1	0.95261046
44	STK3	0.89456392
45	NME1	0.88147739
46	CHEK2	0.85642648
47	CSNK2A1	0.85375464
48	CSNK2A2	0.83988356
49	PLK4	0.81960493
50	PAK2	0.81685384
51	ATR	0.79191040
52	CDK2	0.78151437
53	PAK1	0.75027846
54	BRD4	0.67469433
55	CDK1	0.66916418
56	STK4	0.66068209
57	WEE1	0.65603612
58	STK24	0.63196223
59	EIF2AK1	0.59650451
60	MTOR	0.58195006
61	KDR	0.56566939
62	AKT2	0.53986723
63	MAPK11	0.51712156
64	ATM	0.44599630
65	VRK1	0.43091561
66	GSK3B	0.41065786
67	PRKG1	0.39729010
68	MAPK1	0.36735469
69	TAOK2	0.35468993
70	STK10	0.34185068
71	ACVR1B	0.32980227
72	PRKD1	0.32655048
73	MAPK14	0.32016490
74	DMPK	0.30882735
75	RPS6KA1	0.30020269
76	PRKACB	0.29145944
77	EIF2AK2	0.28236300
78	TNIK	0.27406985
79	CSNK1D	0.27384717
80	TESK1	0.26991777
81	CDK11A	0.25622689
82	PRKD2	0.24482257
83	MAP3K8	0.24194169
84	STK38L	0.24079544
85	CSNK1A1	0.22390909
86	ABL2	0.22326327
87	PAK6	0.19849135
88	PRKAA1	0.19166536
89	MAPK10	0.19112730
90	MAP3K4	0.17557231
91	PRKACA	0.16595056
92	TBK1	0.16380191
93	BMX	0.15159408
94	CLK1	0.15123640
95	MAPK9	0.15106700
96	PRKCG	0.14401337
97	INSRR	0.14166080
98	ARAF	0.13921574
99	MAPK4	0.13481868
100	CAMK1	0.12954190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	6.35735831
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.65717607
3	Regulation of autophagy_Homo sapiens_hsa04140	3.88672415
4	RNA polymerase_Homo sapiens_hsa03020	3.73556114
5	mRNA surveillance pathway_Homo sapiens_hsa03015	3.70689384
6	Ribosome_Homo sapiens_hsa03010	3.43030171
7	Cell cycle_Homo sapiens_hsa04110	3.18315837
8	RNA transport_Homo sapiens_hsa03013	3.04418670
9	Spliceosome_Homo sapiens_hsa03040	2.82181784
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.64126814
11	p53 signaling pathway_Homo sapiens_hsa04115	2.57092880
12	Oocyte meiosis_Homo sapiens_hsa04114	2.55843261
13	Folate biosynthesis_Homo sapiens_hsa00790	2.46602046
14	Taste transduction_Homo sapiens_hsa04742	2.25510361
15	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.23283263
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.97859114
17	Mismatch repair_Homo sapiens_hsa03430	1.57632084
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53784885
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.53353256
20	Base excision repair_Homo sapiens_hsa03410	1.42691198
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35335362
22	Sulfur metabolism_Homo sapiens_hsa00920	1.31309224
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30689611
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.21952258
25	DNA replication_Homo sapiens_hsa03030	1.20497104
26	RNA degradation_Homo sapiens_hsa03018	1.19452194
27	Homologous recombination_Homo sapiens_hsa03440	1.15926081
28	Viral carcinogenesis_Homo sapiens_hsa05203	1.12195558
29	Caffeine metabolism_Homo sapiens_hsa00232	1.12192233
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.08411884
31	Fatty acid elongation_Homo sapiens_hsa00062	0.98336828
32	Huntingtons disease_Homo sapiens_hsa05016	0.97847843
33	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.92218812
34	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91433080
35	Nucleotide excision repair_Homo sapiens_hsa03420	0.88819945
36	MicroRNAs in cancer_Homo sapiens_hsa05206	0.87266014
37	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.86555910
38	Herpes simplex infection_Homo sapiens_hsa05168	0.85833445
39	Steroid biosynthesis_Homo sapiens_hsa00100	0.85381972
40	Purine metabolism_Homo sapiens_hsa00230	0.81382986
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.79187354
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77225627
43	Olfactory transduction_Homo sapiens_hsa04740	0.71714727
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70027515
45	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.68517624
46	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.66037062
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.63143443
48	Wnt signaling pathway_Homo sapiens_hsa04310	0.62812141
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.59754609
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58492412
51	ABC transporters_Homo sapiens_hsa02010	0.57296936
52	Bile secretion_Homo sapiens_hsa04976	0.53030999
53	Hepatitis B_Homo sapiens_hsa05161	0.52020231
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49198313
55	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.48074013
56	AMPK signaling pathway_Homo sapiens_hsa04152	0.45906487
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44987061
58	Parkinsons disease_Homo sapiens_hsa05012	0.44911133
59	Small cell lung cancer_Homo sapiens_hsa05222	0.44796335
60	Insulin secretion_Homo sapiens_hsa04911	0.44431145
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38034879
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38000594
63	Serotonergic synapse_Homo sapiens_hsa04726	0.36853956
64	Protein export_Homo sapiens_hsa03060	0.36479073
65	Acute myeloid leukemia_Homo sapiens_hsa05221	0.36116752
66	Protein digestion and absorption_Homo sapiens_hsa04974	0.32287778
67	Retinol metabolism_Homo sapiens_hsa00830	0.30189655
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29695906
69	Mineral absorption_Homo sapiens_hsa04978	0.28779128
70	FoxO signaling pathway_Homo sapiens_hsa04068	0.28323603
71	Alcoholism_Homo sapiens_hsa05034	0.25633811
72	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.24461719
73	Proteasome_Homo sapiens_hsa03050	0.23819106
74	Nicotine addiction_Homo sapiens_hsa05033	0.19991550
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.19908230
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.19640508
77	GABAergic synapse_Homo sapiens_hsa04727	0.19292627
78	Circadian rhythm_Homo sapiens_hsa04710	0.15461404
79	Arginine biosynthesis_Homo sapiens_hsa00220	0.14920495
80	Metabolic pathways_Homo sapiens_hsa01100	0.13071720
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.12515123
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.12071674
83	Influenza A_Homo sapiens_hsa05164	0.11998675
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.11404311
85	Glutathione metabolism_Homo sapiens_hsa00480	0.09916013
86	Amphetamine addiction_Homo sapiens_hsa05031	0.09436487
87	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.09414828
88	Legionellosis_Homo sapiens_hsa05134	0.08940330
89	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.08857049
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.07601743
91	Prostate cancer_Homo sapiens_hsa05215	0.06677560
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.06590104
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.06069880
94	mTOR signaling pathway_Homo sapiens_hsa04150	0.05548252
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.05524820
96	Morphine addiction_Homo sapiens_hsa05032	0.05323368
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.03890910
98	Pathways in cancer_Homo sapiens_hsa05200	0.03240989
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.02296288
100	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.01679334

PRAMEF15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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