PRAMEF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.45934335
2purine nucleobase biosynthetic process (GO:0009113)5.56075080
3male meiosis I (GO:0007141)5.46399286
4regulation of acrosome reaction (GO:0060046)5.45745870
5positive regulation of protein homooligomerization (GO:0032464)5.37403827
6regulation of spindle organization (GO:0090224)5.09788151
7metaphase plate congression (GO:0051310)5.01253458
8DNA replication checkpoint (GO:0000076)4.93994449
9ribosome assembly (GO:0042255)4.93893599
10nucleobase biosynthetic process (GO:0046112)4.91282178
11protein K6-linked ubiquitination (GO:0085020)4.89278485
12protein localization to kinetochore (GO:0034501)4.88866137
13folic acid metabolic process (GO:0046655)4.55598124
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.47653944
15proteasome assembly (GO:0043248)4.37649308
16transcription from mitochondrial promoter (GO:0006390)4.31246070
17attachment of spindle microtubules to kinetochore (GO:0008608)4.23703857
18ribosome biogenesis (GO:0042254)4.22004377
19establishment of chromosome localization (GO:0051303)4.19601275
20rRNA methylation (GO:0031167)4.17167887
21positive regulation of chromosome segregation (GO:0051984)4.15536755
22protein localization to chromosome, centromeric region (GO:0071459)4.13455473
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.12705975
24regulation of mitotic spindle organization (GO:0060236)4.12539881
25rRNA modification (GO:0000154)4.08324492
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.96626066
27positive regulation of uterine smooth muscle contraction (GO:0070474)3.96178626
28multicellular organism reproduction (GO:0032504)3.96103419
29maturation of 5.8S rRNA (GO:0000460)3.91218724
30spindle checkpoint (GO:0031577)3.90417786
31mitotic sister chromatid segregation (GO:0000070)3.89384668
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.79783774
33mitotic nuclear envelope disassembly (GO:0007077)3.78598775
34regulation of chromosome segregation (GO:0051983)3.73701651
35kinetochore assembly (GO:0051382)3.72430546
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72210541
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72145276
38DNA replication initiation (GO:0006270)3.69800005
39chaperone-mediated protein transport (GO:0072321)3.69749497
40intestinal epithelial cell development (GO:0060576)3.69449268
41CENP-A containing nucleosome assembly (GO:0034080)3.68834716
42mitotic chromosome condensation (GO:0007076)3.65366486
43regulation of exit from mitosis (GO:0007096)3.65036967
447-methylguanosine mRNA capping (GO:0006370)3.61876897
45regulation of telomere maintenance via telomerase (GO:0032210)3.61043930
46inner cell mass cell proliferation (GO:0001833)3.59963034
47kinetochore organization (GO:0051383)3.58676864
48positive regulation of prostaglandin secretion (GO:0032308)3.58652028
49negative regulation of chromosome segregation (GO:0051985)3.58322516
50RNA capping (GO:0036260)3.57197353
517-methylguanosine RNA capping (GO:0009452)3.57197353
52resolution of meiotic recombination intermediates (GO:0000712)3.56404818
53histone exchange (GO:0043486)3.55481488
54male meiosis (GO:0007140)3.55275295
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.53701466
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.52829215
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52739136
58negative regulation of sister chromatid segregation (GO:0033046)3.52739136
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.52739136
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52739136
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.52376259
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.52155607
63protein localization to chromosome (GO:0034502)3.51501981
64membrane disassembly (GO:0030397)3.50951064
65nuclear envelope disassembly (GO:0051081)3.50951064
66DNA deamination (GO:0045006)3.50889946
67chromatin remodeling at centromere (GO:0031055)3.50634644
68blastocyst development (GO:0001824)3.48336084
69regulation of translation in response to stress (GO:0043555)3.47982621
70positive regulation of mitotic sister chromatid separation (GO:1901970)3.46744848
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.46744848
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.46744848
73mitotic spindle checkpoint (GO:0071174)3.45559913
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43453267
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.43275304
76meiotic chromosome segregation (GO:0045132)3.41364820
77aggressive behavior (GO:0002118)3.40733119
78mitotic spindle assembly checkpoint (GO:0007094)3.39800737
79regulation of female receptivity (GO:0045924)3.39437499
80spindle assembly checkpoint (GO:0071173)3.39419601
81DNA replication-independent nucleosome assembly (GO:0006336)3.35876191
82DNA replication-independent nucleosome organization (GO:0034724)3.35876191
83* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.33483591
84regulation of mitotic sister chromatid separation (GO:0010965)3.33202787
85regulation of mitotic sister chromatid segregation (GO:0033047)3.33202787
86regulation of sister chromatid segregation (GO:0033045)3.33202787
87chromosome segregation (GO:0007059)3.32964482
88maturation of SSU-rRNA (GO:0030490)3.31776565
89amino acid salvage (GO:0043102)3.29750659
90L-methionine salvage (GO:0071267)3.29750659
91L-methionine biosynthetic process (GO:0071265)3.29750659
92positive regulation of ligase activity (GO:0051351)3.28295354
93lung-associated mesenchyme development (GO:0060484)3.28231697
94formation of translation preinitiation complex (GO:0001731)3.25885276
95regulation of sister chromatid cohesion (GO:0007063)3.25513876
96positive regulation of catecholamine secretion (GO:0033605)3.24546628
97meiosis I (GO:0007127)3.24015500
98negative regulation of telomere maintenance (GO:0032205)3.23454782
99transcription from RNA polymerase I promoter (GO:0006360)3.23393948
100piRNA metabolic process (GO:0034587)3.23196253
101termination of RNA polymerase I transcription (GO:0006363)3.22578307
102regulation of histone H3-K27 methylation (GO:0061085)3.21862288
103folic acid transport (GO:0015884)3.21711251
104regulation of DNA methylation (GO:0044030)3.21172595
105oocyte maturation (GO:0001556)3.20696279
106termination of RNA polymerase III transcription (GO:0006386)3.20381014
107transcription elongation from RNA polymerase III promoter (GO:0006385)3.20381014
108ribonucleoprotein complex biogenesis (GO:0022613)3.20246480
109transcription elongation from RNA polymerase II promoter (GO:0006368)3.18748695
110transcription elongation from RNA polymerase I promoter (GO:0006362)3.17123441
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.14894160
112regulation of transcription from RNA polymerase I promoter (GO:0006356)3.14604243
113G1/S transition of mitotic cell cycle (GO:0000082)3.14140872
114cell cycle G1/S phase transition (GO:0044843)3.14140872
115autophagic vacuole assembly (GO:0000045)3.12012162
116regulation of cytokine production involved in inflammatory response (GO:1900015)3.04658881
117positive regulation of digestive system process (GO:0060456)3.04381888
118* regulation of retinoic acid receptor signaling pathway (GO:0048385)28.4561152
119female mating behavior (GO:0060180)2.94737698
120regulation of female gonad development (GO:2000194)2.91950198
121regulation of prostaglandin secretion (GO:0032306)2.89354133
122ventricular cardiac muscle cell development (GO:0055015)2.87675327
123regulation of uterine smooth muscle contraction (GO:0070472)2.86119893
124response to UV-C (GO:0010225)2.82845973
125positive regulation of cAMP-mediated signaling (GO:0043950)2.81676062
126meiotic cell cycle (GO:0051321)2.79272978
127drinking behavior (GO:0042756)2.76564812
128sleep (GO:0030431)2.76103456
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.72250309
130transcription from RNA polymerase III promoter (GO:0006383)2.69426603
131regulation of G0 to G1 transition (GO:0070316)2.66859030
132binding of sperm to zona pellucida (GO:0007339)2.66087771
133hyperosmotic salinity response (GO:0042538)2.65228541
134snRNA transcription (GO:0009301)2.65110304
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64993004
136negative regulation of digestive system process (GO:0060457)2.63780019
137regulation of protein homooligomerization (GO:0032462)2.60836644
138regulation of penile erection (GO:0060405)2.60252174
139DNA methylation involved in gamete generation (GO:0043046)2.60156281
140retinal cone cell development (GO:0046549)2.56138861
141protein-cofactor linkage (GO:0018065)2.53661145
142regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52733391
143glycine transport (GO:0015816)2.52426549
144fusion of sperm to egg plasma membrane (GO:0007342)2.52096121
145reproduction (GO:0000003)2.49852115
146regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.46483045
147pseudouridine synthesis (GO:0001522)2.44608419
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44558694
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44558694
150positive regulation of action potential (GO:0045760)2.42673468
151spindle assembly involved in mitosis (GO:0090307)2.42647942
152mitochondrial RNA metabolic process (GO:0000959)2.40638056
153regulation of calcium ion-dependent exocytosis (GO:0017158)2.40628327
154histone mRNA metabolic process (GO:0008334)2.40198145
155meiotic nuclear division (GO:0007126)2.39537913
156exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38099120
157regulation of meiosis I (GO:0060631)2.36855441
158protein polyglutamylation (GO:0018095)2.36481059
159sperm-egg recognition (GO:0035036)2.33321168
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.26903748
161meiotic cell cycle process (GO:1903046)2.25411883
162regulation of cell cycle G2/M phase transition (GO:1902749)2.23528718
163maternal behavior (GO:0042711)2.23266064
164rRNA processing (GO:0006364)2.23020485
165positive regulation of protein oligomerization (GO:0032461)2.20511756
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.19139484
167positive regulation of fatty acid transport (GO:2000193)2.18331471
168positive regulation of humoral immune response (GO:0002922)2.18210377
169rRNA metabolic process (GO:0016072)2.18101933
170protein kinase C signaling (GO:0070528)2.17700581
171detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.16830066
172exploration behavior (GO:0035640)2.16384394
173skeletal muscle tissue regeneration (GO:0043403)2.13615603
174DNA-templated transcription, elongation (GO:0006354)2.12389883
175negative regulation of reproductive process (GO:2000242)2.11725786
176positive regulation of icosanoid secretion (GO:0032305)2.11393499
177chaperone mediated protein folding requiring cofactor (GO:0051085)2.07950903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48826787
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.43792770
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.46631543
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.45547685
5NOTCH1_21737748_ChIP-Seq_TLL_Human4.39504685
6ZNF274_21170338_ChIP-Seq_K562_Hela4.29060740
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.28992043
8EZH2_22144423_ChIP-Seq_EOC_Human4.03811460
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.48746112
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41418622
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.30699331
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27567398
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.26077461
14ETS1_20019798_ChIP-Seq_JURKAT_Human3.23318485
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18425266
16EST1_17652178_ChIP-ChIP_JURKAT_Human3.03094940
17GABP_17652178_ChIP-ChIP_JURKAT_Human3.02033080
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83690548
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72049947
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.61610270
21AR_21909140_ChIP-Seq_LNCAP_Human2.60264921
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57181630
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56819885
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45306149
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39930054
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37982976
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34843036
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26650305
29KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26401156
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22628813
31VDR_23849224_ChIP-Seq_CD4+_Human2.18870603
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13083753
33* ETV1_20927104_ChIP-Seq_GIST48_Human2.10490587
34VDR_22108803_ChIP-Seq_LS180_Human2.09557636
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05160401
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05046558
37IGF1R_20145208_ChIP-Seq_DFB_Human2.03621072
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00136688
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.96158076
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95144550
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93260237
42XRN2_22483619_ChIP-Seq_HELA_Human1.92831227
43* RBPJ_21746931_ChIP-Seq_IB4_Human1.92345264
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87061661
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85295159
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82659870
47* PHF8_20622853_ChIP-Seq_HELA_Human1.81993898
48* NFYB_21822215_ChIP-Seq_K562_Human1.80616881
49GABP_19822575_ChIP-Seq_HepG2_Human1.78988177
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.78175479
51* TBL1_22424771_ChIP-Seq_293T_Human1.73559050
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70128100
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66740672
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.65516259
55FOXP3_21729870_ChIP-Seq_TREG_Human1.65139794
56* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.61770324
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61766757
58* GATA6_21074721_ChIP-Seq_CACO-2_Human1.61683663
59* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.61395576
60DCP1A_22483619_ChIP-Seq_HELA_Human1.59876645
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57340490
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54511665
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53394128
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51395314
65TP53_22573176_ChIP-Seq_HFKS_Human1.49447022
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48218938
67KDM5A_27292631_Chip-Seq_BREAST_Human1.47414776
68TTF2_22483619_ChIP-Seq_HELA_Human1.46852361
69GBX2_23144817_ChIP-Seq_PC3_Human1.46668445
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44151677
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44064758
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41465877
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40355229
74* HNFA_21074721_ChIP-Seq_CACO-2_Human1.39189124
75ZNF263_19887448_ChIP-Seq_K562_Human1.36005778
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.35800440
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.34924638
78PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33429057
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30167785
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27322831
81* NFYA_21822215_ChIP-Seq_K562_Human1.26822713
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23855476
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22810275
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22810275
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22810275
86ELK1_19687146_ChIP-ChIP_HELA_Human1.20788445
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20006681
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19621656
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.16647949
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15900508
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15844887
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15625574
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15167653
94* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13617781
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13520158
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13168777
97IRF1_19129219_ChIP-ChIP_H3396_Human1.12550623
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12467847
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11202228
100CIITA_25753668_ChIP-Seq_RAJI_Human1.10959694
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09870733
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09735409
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09134915
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09070999
105SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08347496
106NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06173514
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05404495
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04074643
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03054709
110NCOR_22424771_ChIP-Seq_293T_Human1.02030758
111ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02028664
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01877014
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01873696
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00469423
115ELK1_22589737_ChIP-Seq_MCF10A_Human1.00348283
116CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99906283
117HOXB7_26014856_ChIP-Seq_BT474_Human0.99653068
118LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98100724
119KAP1_27257070_Chip-Seq_ESCs_Mouse0.98046400
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97789539
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97718969
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97599786
123BCAT_22108803_ChIP-Seq_LS180_Human0.97587857
124POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97241300
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95032481
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94814491
127RNF2_27304074_Chip-Seq_NSC_Mouse0.94714532
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94518290
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93622120
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92743162
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92384926
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91737103
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91700106
134* NANOG_20526341_ChIP-Seq_ESCs_Human0.91329101
135RAC3_21632823_ChIP-Seq_H3396_Human0.90865526
136NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90531171
137BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88733744
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87470064
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87189741
140SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87069147
141MYC_18940864_ChIP-ChIP_HL60_Human0.86754207
142P300_19829295_ChIP-Seq_ESCs_Human0.85787409
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85720179
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85278179
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84454417
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.84277831
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82704741
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82082643
149TAF15_26573619_Chip-Seq_HEK293_Human0.81829862
150REST_21632747_ChIP-Seq_MESCs_Mouse0.80727063
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80566296
152SOX2_19829295_ChIP-Seq_ESCs_Human0.80083352
153NANOG_19829295_ChIP-Seq_ESCs_Human0.80083352
154SMAD4_21799915_ChIP-Seq_A2780_Human0.78803274
155STAT1_20625510_ChIP-Seq_HELA_Human0.78493660
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78467688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.65634547
2MP0001986_abnormal_taste_sensitivity6.21264103
3MP0003111_abnormal_nucleus_morphology5.08252178
4MP0005423_abnormal_somatic_nervous4.95021870
5MP0003718_maternal_effect4.69303307
6MP0004957_abnormal_blastocyst_morpholog4.58251774
7MP0003077_abnormal_cell_cycle4.16413834
8MP0010094_abnormal_chromosome_stability4.14602929
9MP0008057_abnormal_DNA_replication3.75917508
10MP0008058_abnormal_DNA_repair3.27487282
11MP0009379_abnormal_foot_pigmentation2.95235998
12MP0008007_abnormal_cellular_replicative2.93327187
13MP0008932_abnormal_embryonic_tissue2.83082828
14MP0008877_abnormal_DNA_methylation2.71942852
15MP0003806_abnormal_nucleotide_metabolis2.55407682
16MP0001730_embryonic_growth_arrest2.49619304
17MP0008260_abnormal_autophagy2.46278967
18MP0005451_abnormal_body_composition2.44216294
19MP0003786_premature_aging2.14985078
20MP0000350_abnormal_cell_proliferation2.13338660
21MP0003315_abnormal_perineum_morphology2.09546299
22MP0005395_other_phenotype2.07101671
23MP0005394_taste/olfaction_phenotype2.05326313
24MP0005499_abnormal_olfactory_system2.05326313
25MP0006292_abnormal_olfactory_placode1.92964765
26MP0008789_abnormal_olfactory_epithelium1.89499803
27MP0001672_abnormal_embryogenesis/_devel1.86493220
28MP0005380_embryogenesis_phenotype1.86493220
29MP0010307_abnormal_tumor_latency1.69588508
30MP0002210_abnormal_sex_determination1.66267027
31MP0005410_abnormal_fertilization1.62683711
32MP0003123_paternal_imprinting1.61962407
33MP0003646_muscle_fatigue1.59742564
34MP0009840_abnormal_foam_cell1.59613569
35MP0002653_abnormal_ependyma_morphology1.59296644
36MP0006276_abnormal_autonomic_nervous1.57241492
37MP0001929_abnormal_gametogenesis1.56207076
38MP0002127_abnormal_cardiovascular_syste1.55939350
39MP0002138_abnormal_hepatobiliary_system1.55428260
40MP0002085_abnormal_embryonic_tissue1.53445787
41MP0001697_abnormal_embryo_size1.52322263
42MP0003984_embryonic_growth_retardation1.52261854
43MP0001293_anophthalmia1.49051117
44MP0002088_abnormal_embryonic_growth/wei1.47301579
45MP0002396_abnormal_hematopoietic_system1.45961152
46MP0002080_prenatal_lethality1.44696079
47MP0000372_irregular_coat_pigmentation1.44249281
48MP0000653_abnormal_sex_gland1.43542610
49MP0001145_abnormal_male_reproductive1.43424745
50MP0000049_abnormal_middle_ear1.43142682
51MP0002084_abnormal_developmental_patter1.40666012
52MP0001188_hyperpigmentation1.39323479
53MP0002938_white_spotting1.29359049
54MP0010030_abnormal_orbit_morphology1.29106846
55MP0003699_abnormal_female_reproductive1.27956792
56MP0002086_abnormal_extraembryonic_tissu1.27385679
57MP0001119_abnormal_female_reproductive1.26969925
58MP0002102_abnormal_ear_morphology1.25765238
59MP0003195_calcinosis1.25526027
60MP0003937_abnormal_limbs/digits/tail_de1.23868998
61MP0001502_abnormal_circadian_rhythm1.23672827
62MP0003938_abnormal_ear_development1.18912425
63MP0004270_analgesia1.17872083
64MP0003950_abnormal_plasma_membrane1.17233437
65MP0002837_dystrophic_cardiac_calcinosis1.14883961
66MP0009333_abnormal_splenocyte_physiolog1.13588712
67MP0004142_abnormal_muscle_tone1.13423971
68MP0005646_abnormal_pituitary_gland1.12926139
69MP0001968_abnormal_touch/_nociception1.12278777
70MP0002163_abnormal_gland_morphology1.11769516
71MP0003880_abnormal_central_pattern1.09963930
72MP0003221_abnormal_cardiomyocyte_apopto1.07890339
73MP0002234_abnormal_pharynx_morphology1.07212874
74MP0004264_abnormal_extraembryonic_tissu1.05729339
75MP0001881_abnormal_mammary_gland1.05416853
76MP0005551_abnormal_eye_electrophysiolog1.04860958
77MP0000313_abnormal_cell_death1.03874793
78MP0005174_abnormal_tail_pigmentation1.03623173
79MP0005621_abnormal_cell_physiology1.03089854
80MP0005408_hypopigmentation1.02058474
81MP0001661_extended_life_span1.01774098
82MP0005389_reproductive_system_phenotype1.01653709
83MP0002734_abnormal_mechanical_nocicepti1.00144450
84MP0002019_abnormal_tumor_incidence0.98730022
85MP0005647_abnormal_sex_gland0.98194065
86MP0003941_abnormal_skin_development0.98142457
87MP0004215_abnormal_myocardial_fiber0.93731198
88MP0004133_heterotaxia0.93533463
89MP0010352_gastrointestinal_tract_polyps0.93281442
90MP0000631_abnormal_neuroendocrine_gland0.92569877
91MP0005384_cellular_phenotype0.91920075
92MP0002161_abnormal_fertility/fecundity0.91683074
93MP0003567_abnormal_fetal_cardiomyocyte0.91496875
94MP0000627_abnormal_mammary_gland0.91323570
95MP0002254_reproductive_system_inflammat0.91221131
96MP0001486_abnormal_startle_reflex0.90661890
97MP0001919_abnormal_reproductive_system0.88532843
98MP0003943_abnormal_hepatobiliary_system0.86926940
99MP0002233_abnormal_nose_morphology0.84832799
100MP0000358_abnormal_cell_content/0.84415304
101MP0002160_abnormal_reproductive_system0.83860054
102MP0001286_abnormal_eye_development0.83634378
103MP0009672_abnormal_birth_weight0.83383636
104MP0002736_abnormal_nociception_after0.83221068
105MP0000490_abnormal_crypts_of0.83170301
106MP0003936_abnormal_reproductive_system0.82542066
107MP0005645_abnormal_hypothalamus_physiol0.82457089
108MP0005085_abnormal_gallbladder_physiolo0.81151878
109MP0003698_abnormal_male_reproductive0.80699207
110MP0001727_abnormal_embryo_implantation0.79698069
111MP0002751_abnormal_autonomic_nervous0.79448680
112MP0003121_genomic_imprinting0.79350478
113MP0002735_abnormal_chemical_nociception0.77806999
114MP0006035_abnormal_mitochondrial_morpho0.76560231
115MP0002272_abnormal_nervous_system0.76525076
116MP0001485_abnormal_pinna_reflex0.75295154
117MP0003136_yellow_coat_color0.74729372
118MP0003119_abnormal_digestive_system0.74065001
119MP0003186_abnormal_redox_activity0.73989405
120MP0001542_abnormal_bone_strength0.72449294
121MP0003890_abnormal_embryonic-extraembry0.72292963
122MP0001346_abnormal_lacrimal_gland0.71949008
123MP0008995_early_reproductive_senescence0.71561664
124MP0000428_abnormal_craniofacial_morphol0.71319123
125MP0001440_abnormal_grooming_behavior0.71301180
126MP0001545_abnormal_hematopoietic_system0.70986825
127MP0005397_hematopoietic_system_phenotyp0.70986825
128MP0001849_ear_inflammation0.70775624
129MP0005379_endocrine/exocrine_gland_phen0.70509155
130MP0004197_abnormal_fetal_growth/weight/0.70476731
131MP0009745_abnormal_behavioral_response0.70410988
132MP0003755_abnormal_palate_morphology0.69960799
133MP0000015_abnormal_ear_pigmentation0.68972064
134MP0000566_synostosis0.66670043
135MP0003787_abnormal_imprinting0.63995451
136MP0004084_abnormal_cardiac_muscle0.63354497
137MP0005670_abnormal_white_adipose0.62977854
138MP0005076_abnormal_cell_differentiation0.61439514
139MP0000579_abnormal_nail_morphology0.61243189
140MP0002095_abnormal_skin_pigmentation0.60450221
141MP0003878_abnormal_ear_physiology0.60416832
142MP0005377_hearing/vestibular/ear_phenot0.60416832
143MP0005360_urolithiasis0.59923131
144MP0005266_abnormal_metabolism0.58211922
145MP0002111_abnormal_tail_morphology0.56419902
146MP0006036_abnormal_mitochondrial_physio0.55660081
147MP0004019_abnormal_vitamin_homeostasis0.53522320
148MP0001756_abnormal_urination0.52911620
149MP0000516_abnormal_urinary_system0.52826519
150MP0005367_renal/urinary_system_phenotyp0.52826519
151MP0000750_abnormal_muscle_regeneration0.52581960
152MP0000647_abnormal_sebaceous_gland0.51274743
153MP0002269_muscular_atrophy0.50199702
154MP0009703_decreased_birth_body0.50028718
155MP0001529_abnormal_vocalization0.49947241
156MP0002277_abnormal_respiratory_mucosa0.49720681

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.53608079
2Breast hypoplasia (HP:0003187)6.29414661
3Carpal bone hypoplasia (HP:0001498)5.30528027
4Patellar aplasia (HP:0006443)4.60088299
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.55434725
6Abnormality of the labia minora (HP:0012880)4.47756917
7Aplasia/Hypoplasia of the patella (HP:0006498)4.42815073
8Chromsome breakage (HP:0040012)4.30226762
9Cerebral hypomyelination (HP:0006808)4.17504104
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.08666901
11Absent radius (HP:0003974)3.95784661
12Meckel diverticulum (HP:0002245)3.94298027
13Facial hemangioma (HP:0000329)3.87824992
14Rough bone trabeculation (HP:0100670)3.79161349
15Aplasia involving forearm bones (HP:0009822)3.75011133
16Absent forearm bone (HP:0003953)3.75011133
17Aplasia/hypoplasia of the uterus (HP:0008684)3.73219193
18Abnormality of the ileum (HP:0001549)3.69659984
19Abnormality of the preputium (HP:0100587)3.63560832
20Short tibia (HP:0005736)3.59004802
21Aplasia/Hypoplasia of the tibia (HP:0005772)3.54137552
22Premature ovarian failure (HP:0008209)3.47777418
23Pendular nystagmus (HP:0012043)3.47561276
24Abnormality of the aortic arch (HP:0012303)3.42074032
25Septo-optic dysplasia (HP:0100842)3.34593201
26Aplasia/Hypoplasia involving the musculature (HP:0001460)3.31446119
27Aplasia/Hypoplasia of the uvula (HP:0010293)3.31184860
28Patent foramen ovale (HP:0001655)3.26902697
29Absent rod-and cone-mediated responses on ERG (HP:0007688)3.23579628
30Secondary amenorrhea (HP:0000869)3.22772050
31Impulsivity (HP:0100710)3.21613029
32Abnormal pancreas size (HP:0012094)3.17988166
33Abnormality of chromosome stability (HP:0003220)3.15322760
34Pancreatic cysts (HP:0001737)3.06345925
35Male infertility (HP:0003251)3.05708353
36Hypoplasia of the uterus (HP:0000013)3.04339063
37Shawl scrotum (HP:0000049)3.00159951
38Oral leukoplakia (HP:0002745)2.99449512
39Capillary hemangiomas (HP:0005306)2.99148202
40Abnormal trabecular bone morphology (HP:0100671)2.90543344
41Abnormality of the septum pellucidum (HP:0007375)2.85845553
42CNS hypomyelination (HP:0003429)2.82618267
43Dyschromatopsia (HP:0007641)2.81848851
44Multiple enchondromatosis (HP:0005701)2.78710404
45Horseshoe kidney (HP:0000085)2.78363427
46Breast aplasia (HP:0100783)2.74748445
47Bone marrow hypocellularity (HP:0005528)2.73287281
48Abnormal rod and cone electroretinograms (HP:0008323)2.72743798
49Duodenal stenosis (HP:0100867)2.69119828
50Small intestinal stenosis (HP:0012848)2.69119828
51Absent septum pellucidum (HP:0001331)2.67147075
52Prostate neoplasm (HP:0100787)2.63298168
53Limb dystonia (HP:0002451)2.63160156
54Short 1st metacarpal (HP:0010034)2.63110032
55Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.63110032
56Ureteral duplication (HP:0000073)2.62922530
57Hypoplasia of the fovea (HP:0007750)2.61150150
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.61150150
59Aplasia/Hypoplasia of the breasts (HP:0010311)2.60871933
603-Methylglutaconic aciduria (HP:0003535)2.60803794
61Hypercortisolism (HP:0001578)2.60566719
62Progressive muscle weakness (HP:0003323)2.56819798
63Oligodactyly (HP:0012165)2.55631656
64Oligodactyly (hands) (HP:0001180)2.55395179
65Congenital stationary night blindness (HP:0007642)2.55111952
66Gout (HP:0001997)2.54530904
67Absent thumb (HP:0009777)2.51644010
68Aplasia/hypoplasia of the humerus (HP:0006507)2.49632265
69Infertility (HP:0000789)2.47290885
70Degeneration of anterior horn cells (HP:0002398)2.44697040
71Abnormality of the anterior horn cell (HP:0006802)2.44697040
72Molar tooth sign on MRI (HP:0002419)2.41504802
73Abnormality of midbrain morphology (HP:0002418)2.41504802
74Double outlet right ventricle (HP:0001719)2.38825748
75Congenital malformation of the right heart (HP:0011723)2.38825748
76Acute necrotizing encephalopathy (HP:0006965)2.37718521
77Abnormal spermatogenesis (HP:0008669)2.35791571
78Myelodysplasia (HP:0002863)2.35240266
79Abnormality of the umbilical cord (HP:0010881)2.34701876
80Abnormality of the 1st metacarpal (HP:0010009)2.31783329
81Hyperglycinemia (HP:0002154)2.28358514
82Abnormality of the fetal cardiovascular system (HP:0010948)2.27196455
83Abnormal umbilical cord blood vessels (HP:0011403)2.27196455
84Single umbilical artery (HP:0001195)2.27196455
85Tetraplegia (HP:0002445)2.25868271
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25710306
87Aplasia/Hypoplasia of the sternum (HP:0006714)2.25653066
88Short thumb (HP:0009778)2.24404228
89Triphalangeal thumb (HP:0001199)2.23648197
90Microretrognathia (HP:0000308)2.22948559
91Maternal diabetes (HP:0009800)2.20670447
92Hyperglycinuria (HP:0003108)2.19743191
93Adrenal hypoplasia (HP:0000835)2.17995536
94Abnormal mitochondria in muscle tissue (HP:0008316)2.17967534
95Abnormality of the renal collecting system (HP:0004742)2.17684195
96Premature graying of hair (HP:0002216)2.17250114
97Abnormality of alanine metabolism (HP:0010916)2.15879478
98Hyperalaninemia (HP:0003348)2.15879478
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15879478
100Neoplasm of the pancreas (HP:0002894)2.15280650
101Severe visual impairment (HP:0001141)2.15183590
102Azoospermia (HP:0000027)2.12723152
103Constricted visual fields (HP:0001133)2.10988479
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.08691553
105Fused cervical vertebrae (HP:0002949)2.08221531
106Preauricular pit (HP:0004467)2.06500226
107Periauricular skin pits (HP:0100277)2.06500226
108Supernumerary spleens (HP:0009799)2.06305826
109Abnormality of the fovea (HP:0000493)2.05486011
110Microvesicular hepatic steatosis (HP:0001414)2.05278123
111Cleft eyelid (HP:0000625)2.04895006
112Death in infancy (HP:0001522)2.04723092
113Personality changes (HP:0000751)2.03912208
114Abnormality of the duodenum (HP:0002246)2.03874884
115Clubbing of toes (HP:0100760)2.03443936
116Tracheoesophageal fistula (HP:0002575)2.02276508
117Atrioventricular block (HP:0001678)2.02015377
118Reticulocytopenia (HP:0001896)2.00785943
119Pancreatic fibrosis (HP:0100732)1.99194746
120Hyperglycemia (HP:0003074)1.98148643
121Sparse eyelashes (HP:0000653)1.97442797
122Type II lissencephaly (HP:0007260)1.96322730
123Unsteady gait (HP:0002317)1.96224125
124Breech presentation (HP:0001623)1.96094704
125Areflexia of lower limbs (HP:0002522)1.96081810
126Rhinitis (HP:0012384)1.95044086
127Duplicated collecting system (HP:0000081)1.92299577
128Facial cleft (HP:0002006)1.92273934
129Optic nerve hypoplasia (HP:0000609)1.92170659
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91867321
131Fibular aplasia (HP:0002990)1.91576556
132Sloping forehead (HP:0000340)1.91411669
133Flat capital femoral epiphysis (HP:0003370)1.91240643
134Attenuation of retinal blood vessels (HP:0007843)1.91239028
135Aplasia/Hypoplasia of the ulna (HP:0006495)1.91021620
136Decreased central vision (HP:0007663)1.90905285
137Ectopic kidney (HP:0000086)1.90878163
138Testicular atrophy (HP:0000029)1.90662935
139Rhabdomyosarcoma (HP:0002859)1.89748943
140Progressive macrocephaly (HP:0004481)1.89506512
141True hermaphroditism (HP:0010459)1.89455164
142Concave nail (HP:0001598)1.88634650
143Esotropia (HP:0000565)1.88550855
144Delusions (HP:0000746)1.86803799
145External ophthalmoplegia (HP:0000544)1.86465320
146Ankle contracture (HP:0006466)1.86005561
147Irregular epiphyses (HP:0010582)1.85759737
148Abnormality of the carotid arteries (HP:0005344)1.83281851
149Spinal muscular atrophy (HP:0007269)1.82492728
150Abnormal lung lobation (HP:0002101)1.81984739
151Stillbirth (HP:0003826)1.81257095
152Cerebellar dysplasia (HP:0007033)1.81001166
153Stenosis of the external auditory canal (HP:0000402)1.80276264
154Focal motor seizures (HP:0011153)1.80258245
155Abnormal number of erythroid precursors (HP:0012131)1.79869326
156Progressive inability to walk (HP:0002505)1.79251251
157Wrist flexion contracture (HP:0001239)1.79211163
158Choanal stenosis (HP:0000452)1.78249079
159Hypergonadotropic hypogonadism (HP:0000815)1.77627325
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77112846
161Hypoplasia of the radius (HP:0002984)1.77046540
162Choanal atresia (HP:0000453)1.76784459
163Absent hand (HP:0004050)1.76431504
164Posterior subcapsular cataract (HP:0007787)1.76075190
165Ependymoma (HP:0002888)1.75221237
166Malnutrition (HP:0004395)1.75032893
167Abnormality of lateral ventricle (HP:0030047)1.74722072
168Anterior segment dysgenesis (HP:0007700)1.74274338
169Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73652344
170Midline defect of the nose (HP:0004122)1.72006020
171Acute encephalopathy (HP:0006846)1.71191693
172Abnormal biliary tract morphology (HP:0012440)1.70617268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.26691378
2WEE14.71273261
3TRIM283.47387715
4PLK43.40828629
5BRSK23.32789333
6LATS23.11875776
7TTK3.05498349
8WNK33.00377131
9EIF2AK12.76662280
10NEK12.72792228
11CDC72.70573087
12NEK22.69169327
13SRPK12.65807905
14EPHA22.61797615
15STK38L2.50215480
16PLK12.45000429
17CDK192.30180125
18PNCK2.27235456
19AKT32.15644464
20STK162.06503382
21PLK31.93236199
22LATS11.87126725
23BRSK11.86103238
24CHEK21.86061909
25CASK1.78536439
26EIF2AK31.68292412
27AURKB1.60862564
28DYRK21.50927739
29MAP3K41.48734439
30WNK41.48110140
31DYRK31.46796103
32AURKA1.46724457
33PINK11.45597943
34VRK11.44283868
35TSSK61.43180733
36GRK11.41026730
37STK31.35118369
38MAP2K71.32703494
39TAOK31.31360612
40EPHA41.30126324
41BMPR1B1.30120674
42BRAF1.27013073
43ACVR1B1.24146788
44NEK61.23716259
45IRAK31.14258962
46ARAF1.13705974
47MAP4K21.12601378
48TNIK1.11876744
49CHEK11.10595391
50MAP3K81.08190245
51FRK1.05580471
52TESK21.04564193
53MAPK130.99244369
54ADRBK20.99044204
55ZAK0.95483686
56MAP3K60.95397977
57CDK120.94556518
58ABL20.94277177
59CDK70.90290726
60MKNK20.89892849
61PDK30.88463624
62PDK40.88463624
63PKN10.87201855
64TXK0.86239235
65CDK40.85707934
66NME20.84826600
67PRKCI0.84280160
68CDK90.82183763
69RPS6KB20.80829390
70CDK20.80544420
71MELK0.78771086
72STK100.75581188
73PRKCG0.74495723
74PAK10.74472538
75ATR0.73144533
76ERBB40.71466779
77PAK30.69878545
78RAF10.68567915
79ATM0.67846370
80NME10.67125448
81STK40.66562783
82EIF2AK20.63921102
83STK380.62961509
84OXSR10.62550234
85PRKCE0.62327491
86CDK10.61073738
87TAOK10.59847245
88ALK0.59434862
89STK240.58847099
90STK390.56956435
91PDK20.56645788
92CCNB10.56489954
93CDK30.54886905
94MKNK10.53555441
95GSK3A0.52972251
96PRKD20.51341143
97CSNK1E0.49808288
98CSNK2A10.49650043
99TYRO30.49387874
100BCR0.48237166
101PRKCQ0.46433515
102NTRK30.45784161
103PRKACB0.45646590
104RPS6KA40.45193309
105MARK30.45106002
106CSNK2A20.44472801
107NTRK20.41794988
108INSRR0.41043166
109MOS0.40630987
110MAP3K90.39894126
111BCKDK0.39540509
112PRKG10.39441886
113PRKACA0.39345960
114CSNK1G10.39074832
115PRKAA10.38581825
116CAMK2A0.37414624
117PIM20.36931199
118MAPK110.36117510
119NUAK10.35962749
120CLK10.35602984
121PIM10.34995646
122CDK80.34632435
123MAPK100.34009553
124MAP3K110.33042528
125AKT20.32264669
126WNK10.32145202
127VRK20.31104869
128PRKCZ0.30911400
129PBK0.29802990
130MTOR0.28857987
131MUSK0.24296344
132TAOK20.24275451
133MAP3K50.22752939
134MARK10.21325976
135CSNK1G30.19612284
136RPS6KA50.19584702
137PAK40.19546097
138DDR20.19072923
139GSK3B0.18997063
140PAK60.16611597
141CSNK1A10.16436523
142TLK10.16371959

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.51885396
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.37993490
3Proteasome_Homo sapiens_hsa030504.18487387
4RNA transport_Homo sapiens_hsa030133.54260443
5Vitamin B6 metabolism_Homo sapiens_hsa007503.52172351
6DNA replication_Homo sapiens_hsa030303.25360662
7Cell cycle_Homo sapiens_hsa041103.06661172
8Mismatch repair_Homo sapiens_hsa034302.95371018
9Homologous recombination_Homo sapiens_hsa034402.87319966
10Basal transcription factors_Homo sapiens_hsa030222.82623478
11Fanconi anemia pathway_Homo sapiens_hsa034602.76242793
12Pyrimidine metabolism_Homo sapiens_hsa002402.63500576
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.59702048
14Spliceosome_Homo sapiens_hsa030402.54845655
15Pentose phosphate pathway_Homo sapiens_hsa000302.51129369
16Taste transduction_Homo sapiens_hsa047422.42123419
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.37206078
18Nucleotide excision repair_Homo sapiens_hsa034202.31456567
19Sulfur metabolism_Homo sapiens_hsa009202.15917833
20Base excision repair_Homo sapiens_hsa034102.14373839
21Regulation of autophagy_Homo sapiens_hsa041402.09198294
22Folate biosynthesis_Homo sapiens_hsa007901.90269984
23RNA degradation_Homo sapiens_hsa030181.84936949
24p53 signaling pathway_Homo sapiens_hsa041151.82596639
25Ribosome_Homo sapiens_hsa030101.78515916
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78063926
27Nicotine addiction_Homo sapiens_hsa050331.72614070
28Oocyte meiosis_Homo sapiens_hsa041141.62185596
29Purine metabolism_Homo sapiens_hsa002301.61290591
30Parkinsons disease_Homo sapiens_hsa050121.60749093
31One carbon pool by folate_Homo sapiens_hsa006701.49745559
32Protein export_Homo sapiens_hsa030601.45187767
33mRNA surveillance pathway_Homo sapiens_hsa030151.42634583
34Non-homologous end-joining_Homo sapiens_hsa034501.38134007
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36968887
36Biosynthesis of amino acids_Homo sapiens_hsa012301.33437017
37Oxidative phosphorylation_Homo sapiens_hsa001901.32939303
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27294919
39Epstein-Barr virus infection_Homo sapiens_hsa051691.25624124
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23960345
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.22907249
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22854194
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.22749342
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20901412
45Phototransduction_Homo sapiens_hsa047441.19582597
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.15358873
47Fructose and mannose metabolism_Homo sapiens_hsa000511.09354509
48Cardiac muscle contraction_Homo sapiens_hsa042601.08956290
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.02594633
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01063246
51Olfactory transduction_Homo sapiens_hsa047400.98504476
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97008014
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96744252
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89809145
55Circadian rhythm_Homo sapiens_hsa047100.87386625
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82411921
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82045161
58Insulin secretion_Homo sapiens_hsa049110.80643414
59Fatty acid elongation_Homo sapiens_hsa000620.80416955
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78630620
61Carbon metabolism_Homo sapiens_hsa012000.78458566
62Arginine and proline metabolism_Homo sapiens_hsa003300.77342383
63Morphine addiction_Homo sapiens_hsa050320.76299803
64Glutathione metabolism_Homo sapiens_hsa004800.73472114
65GABAergic synapse_Homo sapiens_hsa047270.72234153
66Linoleic acid metabolism_Homo sapiens_hsa005910.71471957
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65682602
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65477675
69Fatty acid biosynthesis_Homo sapiens_hsa000610.63615099
70Vitamin digestion and absorption_Homo sapiens_hsa049770.62969313
71Serotonergic synapse_Homo sapiens_hsa047260.59862549
72Alzheimers disease_Homo sapiens_hsa050100.59452244
73Huntingtons disease_Homo sapiens_hsa050160.57537867
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56198457
75Sphingolipid metabolism_Homo sapiens_hsa006000.54665426
76Arginine biosynthesis_Homo sapiens_hsa002200.54570517
77Arachidonic acid metabolism_Homo sapiens_hsa005900.52902181
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52094883
79ABC transporters_Homo sapiens_hsa020100.50093166
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48915350
81Dorso-ventral axis formation_Homo sapiens_hsa043200.48433897
82Metabolic pathways_Homo sapiens_hsa011000.47687571
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47450989
84Nitrogen metabolism_Homo sapiens_hsa009100.46458802
85Selenocompound metabolism_Homo sapiens_hsa004500.44318641
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42687093
87Circadian entrainment_Homo sapiens_hsa047130.42645966
88Wnt signaling pathway_Homo sapiens_hsa043100.41217362
89Galactose metabolism_Homo sapiens_hsa000520.41149627
90Amphetamine addiction_Homo sapiens_hsa050310.40587226
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.37258454
92Glutamatergic synapse_Homo sapiens_hsa047240.36971364
93MicroRNAs in cancer_Homo sapiens_hsa052060.36958896
94mTOR signaling pathway_Homo sapiens_hsa041500.36841031
95African trypanosomiasis_Homo sapiens_hsa051430.36682079
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36661774
97Viral carcinogenesis_Homo sapiens_hsa052030.35780751
98Propanoate metabolism_Homo sapiens_hsa006400.35350650
99Ether lipid metabolism_Homo sapiens_hsa005650.34769768
100TGF-beta signaling pathway_Homo sapiens_hsa043500.34333199
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33933425
102Sulfur relay system_Homo sapiens_hsa041220.33820004
103Chemical carcinogenesis_Homo sapiens_hsa052040.33467032
104Herpes simplex infection_Homo sapiens_hsa051680.31012371
105Tryptophan metabolism_Homo sapiens_hsa003800.30136823
106Hippo signaling pathway_Homo sapiens_hsa043900.30122588
107Dopaminergic synapse_Homo sapiens_hsa047280.28780270
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28079020
109Calcium signaling pathway_Homo sapiens_hsa040200.26264307
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25501581
111Long-term depression_Homo sapiens_hsa047300.24879950
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24868199
113Inositol phosphate metabolism_Homo sapiens_hsa005620.24262204
114FoxO signaling pathway_Homo sapiens_hsa040680.23260337
115Fat digestion and absorption_Homo sapiens_hsa049750.22189083
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21927137
117Butanoate metabolism_Homo sapiens_hsa006500.21806349
118Cocaine addiction_Homo sapiens_hsa050300.21692386
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18623782
120Alcoholism_Homo sapiens_hsa050340.15887738
121HTLV-I infection_Homo sapiens_hsa051660.15011739
122Tight junction_Homo sapiens_hsa045300.14973775
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14844914
124Thyroid cancer_Homo sapiens_hsa052160.14645514
125beta-Alanine metabolism_Homo sapiens_hsa004100.13793264
126Glycerolipid metabolism_Homo sapiens_hsa005610.12678979
127Renin-angiotensin system_Homo sapiens_hsa046140.12460207
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.08396507
129AMPK signaling pathway_Homo sapiens_hsa041520.07928180
130Small cell lung cancer_Homo sapiens_hsa052220.06174431
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05713696
132Antigen processing and presentation_Homo sapiens_hsa046120.03942672
133Ovarian steroidogenesis_Homo sapiens_hsa049130.03626854
134Renal cell carcinoma_Homo sapiens_hsa052110.03518673
135Steroid biosynthesis_Homo sapiens_hsa001000.02294678
136Other glycan degradation_Homo sapiens_hsa005110.02037560
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01957454
138Hedgehog signaling pathway_Homo sapiens_hsa043400.01769374
139Caffeine metabolism_Homo sapiens_hsa002320.01313611
140Mineral absorption_Homo sapiens_hsa049780.00786048
141Retinol metabolism_Homo sapiens_hsa008300.00148802
142Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0705580
143Pathways in cancer_Homo sapiens_hsa05200-0.0699218
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0429412
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0264554
146Colorectal cancer_Homo sapiens_hsa05210-0.0200716
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0191158
148Shigellosis_Homo sapiens_hsa05131-0.0170538
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0169666

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