ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	6.31544877
2	positive regulation of protein homooligomerization (GO:0032464)	5.95671617
3	transcription from mitochondrial promoter (GO:0006390)	5.57297219
4	meiosis I (GO:0007127)	5.49119009
5	rRNA modification (GO:0000154)	4.93274471
6	regulation of DNA methylation (GO:0044030)	4.63062748
7	chaperone-mediated protein transport (GO:0072321)	4.42607586
8	rRNA methylation (GO:0031167)	4.37227284
9	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.29113851
10	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.23183340
11	regulation of acrosome reaction (GO:0060046)	4.05705404
12	autophagic vacuole assembly (GO:0000045)	4.04976573
13	* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	33.8468978
14	multicellular organism reproduction (GO:0032504)	3.91061931
15	ribosome assembly (GO:0042255)	3.87179871
16	mitotic metaphase plate congression (GO:0007080)	3.82955145
17	male meiosis (GO:0007140)	3.80291696
18	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.63840933
19	termination of RNA polymerase III transcription (GO:0006386)	3.63840933
20	ventricular cardiac muscle cell development (GO:0055015)	3.60272927
21	regulation of G0 to G1 transition (GO:0070316)	3.44638377
22	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.22529353
23	mitochondrial RNA metabolic process (GO:0000959)	3.21571088
24	very-low-density lipoprotein particle assembly (GO:0034379)	3.21377981
25	attachment of spindle microtubules to kinetochore (GO:0008608)	3.16518118
26	regulation of spindle organization (GO:0090224)	3.13905675
27	regulation of protein homooligomerization (GO:0032462)	3.08165936
28	aggressive behavior (GO:0002118)	3.06812993
29	skeletal muscle tissue regeneration (GO:0043403)	3.04096550
30	metaphase plate congression (GO:0051310)	3.00825177
31	* regulation of retinoic acid receptor signaling pathway (GO:0048385)	28.3092184
32	piRNA metabolic process (GO:0034587)	2.95311596
33	positive regulation of chromosome segregation (GO:0051984)	2.94580555
34	protein K6-linked ubiquitination (GO:0085020)	2.91456900
35	positive regulation of cAMP-mediated signaling (GO:0043950)	2.90268171
36	regulation of oxidative phosphorylation (GO:0002082)	2.84549613
37	regulation of female gonad development (GO:2000194)	2.83415880
38	polyamine biosynthetic process (GO:0006596)	2.83011322
39	rRNA processing (GO:0006364)	2.81268768
40	mitotic chromosome condensation (GO:0007076)	2.80358080
41	regulation of female receptivity (GO:0045924)	2.79106431
42	ribosome biogenesis (GO:0042254)	2.77733585
43	maturation of 5.8S rRNA (GO:0000460)	2.75716151
44	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.75178912
45	meiotic cell cycle (GO:0051321)	2.73228887
46	rRNA metabolic process (GO:0016072)	2.71258212
47	meiotic nuclear division (GO:0007126)	2.71112855
48	regulation of mitotic spindle organization (GO:0060236)	2.68848410
49	transcription from RNA polymerase III promoter (GO:0006383)	2.68262748
50	maturation of SSU-rRNA (GO:0030490)	2.66365208
51	regulation of penile erection (GO:0060405)	2.66003267
52	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.65631576
53	reproduction (GO:0000003)	2.64073317
54	response to UV-C (GO:0010225)	2.61428628
55	snRNA transcription (GO:0009301)	2.59849743
56	proteasome assembly (GO:0043248)	2.59800914
57	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.59660434
58	meiotic cell cycle process (GO:1903046)	2.58979702
59	positive regulation of protein oligomerization (GO:0032461)	2.58145325
60	N-terminal protein amino acid acetylation (GO:0006474)	2.58083339
61	positive regulation of prostaglandin secretion (GO:0032308)	2.55616979
62	drinking behavior (GO:0042756)	2.53983901
63	pseudouridine synthesis (GO:0001522)	2.52104737
64	regulation of uterine smooth muscle contraction (GO:0070472)	2.51841099
65	ribonucleoprotein complex biogenesis (GO:0022613)	2.46084401
66	hyperosmotic salinity response (GO:0042538)	2.44213044
67	negative regulation of reproductive process (GO:2000242)	2.42176198
68	histone mRNA metabolic process (GO:0008334)	2.40069316
69	positive regulation of catecholamine secretion (GO:0033605)	2.38972569
70	female mating behavior (GO:0060180)	2.38167781
71	regulation of meiosis I (GO:0060631)	2.37784627
72	transcription elongation from RNA polymerase II promoter (GO:0006368)	2.36767673
73	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.36286804
74	regulation of transforming growth factor beta2 production (GO:0032909)	2.35560888
75	binding of sperm to zona pellucida (GO:0007339)	2.32075743
76	cellular biogenic amine biosynthetic process (GO:0042401)	2.30535093
77	positive regulation of digestive system process (GO:0060456)	2.29579031
78	regulation of transforming growth factor beta1 production (GO:0032908)	2.28991986
79	DNA-templated transcription, elongation (GO:0006354)	2.28843713
80	protein localization to chromosome, centromeric region (GO:0071459)	2.28059322
81	intestinal epithelial cell development (GO:0060576)	2.27850382
82	oocyte development (GO:0048599)	2.26096850
83	DNA methylation involved in gamete generation (GO:0043046)	2.24817022
84	ribosomal small subunit biogenesis (GO:0042274)	2.24230283
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.23721717
86	DNA replication checkpoint (GO:0000076)	2.21854366
87	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.21584130
88	telomere maintenance via telomere lengthening (GO:0010833)	2.19919041
89	DNA-templated transcription, termination (GO:0006353)	2.19339548
90	mitotic sister chromatid segregation (GO:0000070)	2.19099161
91	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.19052061
92	CENP-A containing nucleosome assembly (GO:0034080)	2.18891791
93	regulation of cellular respiration (GO:0043457)	2.18777518
94	amine biosynthetic process (GO:0009309)	2.18523359
95	positive regulation of cardiac muscle cell proliferation (GO:0060045)	2.18418876
96	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.17815123
97	response to acidic pH (GO:0010447)	2.17541668
98	negative regulation of RNA splicing (GO:0033119)	2.17425608
99	protein targeting to mitochondrion (GO:0006626)	2.16939736
100	negative regulation of digestive system process (GO:0060457)	2.14317438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.66104587
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.28386140
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.16344482
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.97143063
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.91603625
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.75175921
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.56229847
8	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.56229847
9	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.56229847
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.34309404
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.29763350
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.28388075
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.88421375
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.82998735
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81898587
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80003652
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.66510940
18	E2F7_22180533_ChIP-Seq_HELA_Human	2.58482926
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.56251725
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.51923470
21	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.43987253
22	EZH2_22144423_ChIP-Seq_EOC_Human	2.41263057
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.30144789
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20201101
25	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.19553441
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.15083846
27	VDR_23849224_ChIP-Seq_CD4+_Human	2.06154089
28	* ETV1_20927104_ChIP-Seq_GIST48_Human	2.01295960
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.97219278
30	* RBPJ_21746931_ChIP-Seq_IB4_Human	1.84901682
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.82697779
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.79117684
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.74811432
34	* PHF8_20622853_ChIP-Seq_HELA_Human	1.71607565
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.71058823
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.70755701
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.70562970
38	* NFYB_21822215_ChIP-Seq_K562_Human	1.66860889
39	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.62633529
40	AR_21909140_ChIP-Seq_LNCAP_Human	1.61883479
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.61341101
42	* TBL1_22424771_ChIP-Seq_293T_Human	1.60362561
43	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.59613301
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.57033602
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.56926315
46	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53065437
47	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.50357610
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48969103
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.47869133
50	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47035363
51	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.46895798
52	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.45660382
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.39376532
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35153597
55	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.34886787
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33055653
57	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.30188256
58	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.25835914
59	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.25804117
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25228608
61	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.23542364
62	XRN2_22483619_ChIP-Seq_HELA_Human	1.22125424
63	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.21045189
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.19208557
65	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.18971192
66	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.14703386
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13741588
68	* NFYA_21822215_ChIP-Seq_K562_Human	1.12024058
69	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10820958
70	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06163902
71	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03159036
72	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.99696211
73	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99141426
74	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.97301395
75	ZNF263_19887448_ChIP-Seq_K562_Human	0.94869382
76	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94615360
77	VDR_22108803_ChIP-Seq_LS180_Human	0.92732773
78	DCP1A_22483619_ChIP-Seq_HELA_Human	0.90431500
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90217794
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89254856
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88187986
82	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88154257
83	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.88100598
84	RAC3_21632823_ChIP-Seq_H3396_Human	0.87766345
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87724458
86	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.87548258
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.87355749
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87182782
89	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.85740728
90	NANOG_20526341_ChIP-Seq_ESCs_Human	0.83404096
91	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.81848419
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.79807983
93	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.79457283
94	STAT1_20625510_ChIP-Seq_HELA_Human	0.78273306
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.78013124
96	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.76134885
97	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.75535366
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.75305975
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.74870546
100	* NCOR_22424771_ChIP-Seq_293T_Human	0.74186095

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	7.17518175
2	MP0005423_abnormal_somatic_nervous	6.24322035
3	MP0006292_abnormal_olfactory_placode	4.57084165
4	MP0003718_maternal_effect	4.33807043
5	MP0003693_abnormal_embryo_hatching	3.50110236
6	MP0003646_muscle_fatigue	2.81179016
7	MP0009379_abnormal_foot_pigmentation	2.79335024
8	MP0008260_abnormal_autophagy	2.73983233
9	MP0004957_abnormal_blastocyst_morpholog	2.70111607
10	MP0003111_abnormal_nucleus_morphology	2.49672557
11	MP0008877_abnormal_DNA_methylation	2.46819617
12	MP0002127_abnormal_cardiovascular_syste	2.29712512
13	MP0008058_abnormal_DNA_repair	2.14534532
14	MP0003077_abnormal_cell_cycle	2.06224658
15	MP0001929_abnormal_gametogenesis	2.05406848
16	MP0002160_abnormal_reproductive_system	2.02431436
17	MP0002210_abnormal_sex_determination	2.00581163
18	MP0005499_abnormal_olfactory_system	1.92939976
19	MP0005394_taste/olfaction_phenotype	1.92939976
20	MP0002277_abnormal_respiratory_mucosa	1.88737557
21	MP0010094_abnormal_chromosome_stability	1.86978374
22	MP0003136_yellow_coat_color	1.84956670
23	MP0005395_other_phenotype	1.66222679
24	MP0010307_abnormal_tumor_latency	1.65558198
25	MP0009333_abnormal_splenocyte_physiolog	1.63548440
26	MP0005389_reproductive_system_phenotype	1.61202314
27	MP0005410_abnormal_fertilization	1.53816872
28	MP0008789_abnormal_olfactory_epithelium	1.49474499
29	MP0006036_abnormal_mitochondrial_physio	1.41716631
30	MP0000653_abnormal_sex_gland	1.33252229
31	MP0005380_embryogenesis_phenotype	1.29696450
32	MP0001672_abnormal_embryogenesis/_devel	1.29696450
33	MP0003698_abnormal_male_reproductive	1.28941403
34	MP0001145_abnormal_male_reproductive	1.24903503
35	MP0003938_abnormal_ear_development	1.23991243
36	MP0005647_abnormal_sex_gland	1.20053122
37	MP0004215_abnormal_myocardial_fiber	1.18441417
38	MP0008057_abnormal_DNA_replication	1.18236042
39	MP0006035_abnormal_mitochondrial_morpho	1.17454178
40	MP0002161_abnormal_fertility/fecundity	1.17367588
41	MP0000372_irregular_coat_pigmentation	1.15947212
42	MP0001697_abnormal_embryo_size	1.15921624
43	MP0003699_abnormal_female_reproductive	1.15792272
44	MP0008932_abnormal_embryonic_tissue	1.11315415
45	MP0006276_abnormal_autonomic_nervous	1.11095818
46	MP0003195_calcinosis	1.10947597
47	MP0001529_abnormal_vocalization	1.10007797
48	MP0009840_abnormal_foam_cell	1.09533060
49	MP0000358_abnormal_cell_content/	1.07000052
50	MP0003984_embryonic_growth_retardation	1.06929886
51	MP0002138_abnormal_hepatobiliary_system	1.04840718
52	MP0000350_abnormal_cell_proliferation	1.04672807
53	MP0002088_abnormal_embryonic_growth/wei	1.03296266
54	MP0005646_abnormal_pituitary_gland	1.00236245
55	MP0001881_abnormal_mammary_gland	1.00040187
56	MP0001730_embryonic_growth_arrest	0.99581289
57	MP0003186_abnormal_redox_activity	0.98272630
58	MP0001293_anophthalmia	0.97576241
59	MP0008995_early_reproductive_senescence	0.96351699
60	MP0004885_abnormal_endolymph	0.91046140
61	MP0004019_abnormal_vitamin_homeostasis	0.90966289
62	MP0010030_abnormal_orbit_morphology	0.86860991
63	MP0000049_abnormal_middle_ear	0.86639282
64	MP0003943_abnormal_hepatobiliary_system	0.86160648
65	MP0001119_abnormal_female_reproductive	0.84135065
66	MP0002735_abnormal_chemical_nociception	0.82922386
67	MP0001485_abnormal_pinna_reflex	0.80568713
68	MP0005551_abnormal_eye_electrophysiolog	0.79475036
69	MP0001919_abnormal_reproductive_system	0.79220418
70	MP0001968_abnormal_touch/_nociception	0.77932608
71	MP0005085_abnormal_gallbladder_physiolo	0.75637249
72	MP0000750_abnormal_muscle_regeneration	0.75059849
73	MP0004142_abnormal_muscle_tone	0.72626176
74	MP0002085_abnormal_embryonic_tissue	0.72367228
75	MP0003121_genomic_imprinting	0.72168320
76	MP0000647_abnormal_sebaceous_gland	0.71769686
77	MP0002254_reproductive_system_inflammat	0.71042967
78	MP0002084_abnormal_developmental_patter	0.70852514
79	MP0000015_abnormal_ear_pigmentation	0.70743686
80	MP0001666_abnormal_nutrient_absorption	0.70704614
81	MP0003936_abnormal_reproductive_system	0.70207816
82	MP0003567_abnormal_fetal_cardiomyocyte	0.70074938
83	MP0000631_abnormal_neuroendocrine_gland	0.69828355
84	MP0003890_abnormal_embryonic-extraembry	0.69805758
85	MP0003880_abnormal_central_pattern	0.69713473
86	MP0003119_abnormal_digestive_system	0.68902048
87	MP0005367_renal/urinary_system_phenotyp	0.68744588
88	MP0000516_abnormal_urinary_system	0.68744588
89	MP0002080_prenatal_lethality	0.67185249
90	MP0001286_abnormal_eye_development	0.65888504
91	MP0005174_abnormal_tail_pigmentation	0.63192668
92	MP0001502_abnormal_circadian_rhythm	0.62727231
93	MP0005451_abnormal_body_composition	0.62564334
94	MP0003950_abnormal_plasma_membrane	0.60651366
95	MP0002095_abnormal_skin_pigmentation	0.60088864
96	MP0002736_abnormal_nociception_after	0.59735930
97	MP0002873_normal_phenotype	0.59486855
98	MP0002169_no_abnormal_phenotype	0.59230679
99	MP0005360_urolithiasis	0.58729084
100	MP0000490_abnormal_crypts_of	0.57670129

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	6.15577331
2	Congenital malformation of the right heart (HP:0011723)	4.60993825
3	Double outlet right ventricle (HP:0001719)	4.60993825
4	Birth length less than 3rd percentile (HP:0003561)	4.22277500
5	Aplasia/hypoplasia of the uterus (HP:0008684)	4.17478950
6	Patent foramen ovale (HP:0001655)	4.17060526
7	Abnormal pancreas size (HP:0012094)	4.13619101
8	Carpal bone hypoplasia (HP:0001498)	3.91577405
9	Abnormal umbilical cord blood vessels (HP:0011403)	3.67933868
10	Single umbilical artery (HP:0001195)	3.67933868
11	Abnormality of the fetal cardiovascular system (HP:0010948)	3.67933868
12	Abnormality of the aortic arch (HP:0012303)	3.55037031
13	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.46616255
14	Hypoplasia of the uterus (HP:0000013)	3.37330978
15	Premature ovarian failure (HP:0008209)	3.28662289
16	Malnutrition (HP:0004395)	3.22437084
17	Ureteral duplication (HP:0000073)	3.17176904
18	Microvesicular hepatic steatosis (HP:0001414)	3.15427614
19	Hypercortisolism (HP:0001578)	2.98325392
20	Short tibia (HP:0005736)	2.83601213
21	Abnormality of the septum pellucidum (HP:0007375)	2.75163332
22	Preauricular pit (HP:0004467)	2.74502105
23	Periauricular skin pits (HP:0100277)	2.74502105
24	Hypoglycemic seizures (HP:0002173)	2.73762959
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.73336527
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.71880826
27	Hypoplasia of the fovea (HP:0007750)	2.71783135
28	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.71783135
29	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.59084708
30	Constricted visual fields (HP:0001133)	2.58488362
31	Hypergonadotropic hypogonadism (HP:0000815)	2.58049508
32	Pendular nystagmus (HP:0012043)	2.57838029
33	Fused cervical vertebrae (HP:0002949)	2.56710337
34	Concave nail (HP:0001598)	2.54588217
35	Abnormality of magnesium homeostasis (HP:0004921)	2.53711089
36	Hyperglycemia (HP:0003074)	2.50232240
37	Infertility (HP:0000789)	2.46889257
38	Horseshoe kidney (HP:0000085)	2.43490561
39	Limb dystonia (HP:0002451)	2.40923312
40	Hypophosphatemic rickets (HP:0004912)	2.39614295
41	Dysphonia (HP:0001618)	2.39585764
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.39068257
43	Absent radius (HP:0003974)	2.29819698
44	Cleft eyelid (HP:0000625)	2.29596469
45	Glycosuria (HP:0003076)	2.27719761
46	Abnormality of urine glucose concentration (HP:0011016)	2.27719761
47	Microretrognathia (HP:0000308)	2.24554328
48	Hypomagnesemia (HP:0002917)	2.22988843
49	Meckel diverticulum (HP:0002245)	2.22010322
50	Abnormality of the ileum (HP:0001549)	2.21454864
51	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.21061971
52	Short 1st metacarpal (HP:0010034)	2.21061971
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20250363
54	Abnormality of alanine metabolism (HP:0010916)	2.20250363
55	Hyperalaninemia (HP:0003348)	2.20250363
56	Progressive muscle weakness (HP:0003323)	2.20185653
57	Symptomatic seizures (HP:0011145)	2.18635312
58	Aplasia involving forearm bones (HP:0009822)	2.18262726
59	Absent forearm bone (HP:0003953)	2.18262726
60	Sensory axonal neuropathy (HP:0003390)	2.17736650
61	Attenuation of retinal blood vessels (HP:0007843)	2.16273924
62	Midline defect of the nose (HP:0004122)	2.15426827
63	Absent thumb (HP:0009777)	2.15207769
64	Cerebral hypomyelination (HP:0006808)	2.14997791
65	Abnormality of the fovea (HP:0000493)	2.14842152
66	Facial cleft (HP:0002006)	2.14511158
67	Stenosis of the external auditory canal (HP:0000402)	2.13497703
68	Ileus (HP:0002595)	2.12712523
69	3-Methylglutaconic aciduria (HP:0003535)	2.11437900
70	Increased serum lactate (HP:0002151)	2.11005268
71	Posterior subcapsular cataract (HP:0007787)	2.10543523
72	Reticulocytopenia (HP:0001896)	2.09503057
73	Absent septum pellucidum (HP:0001331)	2.09101215
74	Rhinitis (HP:0012384)	2.08536780
75	Abnormality of the preputium (HP:0100587)	2.08214099
76	Abnormal biliary tract morphology (HP:0012440)	2.03305778
77	Multiple enchondromatosis (HP:0005701)	2.02089714
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01626284
79	Abnormality of cells of the erythroid lineage (HP:0012130)	2.00656779
80	Abnormal number of erythroid precursors (HP:0012131)	1.99655440
81	Tetany (HP:0001281)	1.99108835
82	Reduced antithrombin III activity (HP:0001976)	1.97145947
83	Median cleft lip (HP:0000161)	1.94669679
84	Osteomalacia (HP:0002749)	1.94248520
85	Abnormality of the 1st metacarpal (HP:0010009)	1.94194562
86	Abnormal spermatogenesis (HP:0008669)	1.91796363
87	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.90707895
88	Abnormality of the umbilical cord (HP:0010881)	1.89009042
89	CNS hypomyelination (HP:0003429)	1.88429064
90	Azoospermia (HP:0000027)	1.88039758
91	Abnormality of the pons (HP:0007361)	1.87643571
92	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.87273251
93	Aplasia/hypoplasia of the humerus (HP:0006507)	1.87053202
94	Supernumerary spleens (HP:0009799)	1.85762557
95	Truncus arteriosus (HP:0001660)	1.83111956
96	Breast hypoplasia (HP:0003187)	1.80517469
97	Pancreatic cysts (HP:0001737)	1.79658280
98	Hyperinsulinemic hypoglycemia (HP:0000825)	1.78075435
99	Hypoplasia of the pons (HP:0012110)	1.77091358
100	Skin pits (HP:0100276)	1.76650816

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	5.00596502
2	SRPK1	4.35872587
3	TESK2	4.12435852
4	PBK	3.17838670
5	STK16	3.10139158
6	PDK2	3.03778676
7	TRIM28	2.95772237
8	LATS2	2.90819235
9	CDK19	2.36630154
10	WNK3	2.33081643
11	PLK1	2.19619677
12	TAOK3	2.09400002
13	NEK6	1.95810336
14	PLK3	1.93787315
15	BRSK2	1.92205122
16	BRSK1	1.90665082
17	NEK2	1.76455679
18	AURKA	1.74975819
19	MARK3	1.55316175
20	AURKB	1.46971414
21	NUAK1	1.34887125
22	FRK	1.34379184
23	EIF2AK3	1.34114394
24	STK39	1.30395399
25	DYRK3	1.29726339
26	PINK1	1.23282682
27	BMX	1.22021364
28	CHEK1	1.17213129
29	OXSR1	1.14721587
30	CHEK2	1.12568361
31	ZAK	1.10160207
32	PLK4	1.06976167
33	PKN1	1.06919133
34	CDC7	1.00077684
35	PRKCI	0.99083210
36	STK4	0.96404778
37	PIM1	0.93370212
38	CSNK2A1	0.92404726
39	CSNK1E	0.88989012
40	WNK4	0.88791976
41	GSK3A	0.87742894
42	GRK1	0.87121657
43	TTK	0.86349894
44	TLK1	0.84937366
45	MAP3K4	0.84606897
46	PAK1	0.83321008
47	MAP3K5	0.81766812
48	CDK7	0.76909417
49	PAK6	0.75853178
50	CSNK2A2	0.73390536
51	NTRK3	0.72315119
52	ATR	0.71776278
53	STK10	0.71063638
54	MAP4K2	0.70367424
55	EPHA4	0.70197341
56	ACVR1B	0.69202731
57	MST4	0.69036488
58	STK38L	0.68700019
59	TNIK	0.66932928
60	PRKCG	0.61704085
61	STK3	0.61671926
62	PAK2	0.60629123
63	AKT2	0.60243131
64	CDK2	0.59569164
65	WEE1	0.58771029
66	CDK9	0.58680228
67	CSNK1A1	0.56507143
68	CDK1	0.55077461
69	AKT3	0.54871789
70	RAF1	0.53583592
71	PRKCE	0.53456810
72	MAP3K9	0.53333400
73	BMPR1B	0.51537554
74	VRK1	0.51321650
75	MELK	0.50987114
76	INSRR	0.49401126
77	PRKG1	0.49235668
78	ATM	0.47167901
79	PHKG1	0.43604984
80	PHKG2	0.43604984
81	PIM2	0.42665162
82	MAP2K7	0.42621415
83	PRKACB	0.38939930
84	CAMK4	0.38494368
85	ABL2	0.38277290
86	MAPK13	0.38038767
87	LRRK2	0.35659162
88	MAPK11	0.35320802
89	GSK3B	0.34019730
90	EIF2AK1	0.32830570
91	EIF2AK2	0.32759648
92	PIK3CG	0.32476145
93	RPS6KA1	0.31421175
94	PRKACA	0.30347719
95	NME1	0.30329480
96	MAPK1	0.29718255
97	PRKD2	0.28599116
98	PRKD1	0.28546235
99	MAP3K8	0.27953014
100	MARK1	0.27804140

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	5.07858089
2	Basal transcription factors_Homo sapiens_hsa03022	5.02160371
3	Regulation of autophagy_Homo sapiens_hsa04140	4.24557995
4	RNA polymerase_Homo sapiens_hsa03020	4.14023924
5	Ribosome_Homo sapiens_hsa03010	3.61782321
6	RNA transport_Homo sapiens_hsa03013	2.99722469
7	mRNA surveillance pathway_Homo sapiens_hsa03015	2.80816544
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.65688329
9	Folate biosynthesis_Homo sapiens_hsa00790	2.60165382
10	Spliceosome_Homo sapiens_hsa03040	2.54557881
11	Cell cycle_Homo sapiens_hsa04110	2.09340558
12	Oocyte meiosis_Homo sapiens_hsa04114	1.90536980
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.85326958
14	Taste transduction_Homo sapiens_hsa04742	1.85158775
15	p53 signaling pathway_Homo sapiens_hsa04115	1.84660831
16	RNA degradation_Homo sapiens_hsa03018	1.80534395
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79522136
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.74723501
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65999499
20	Homologous recombination_Homo sapiens_hsa03440	1.57844271
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57092270
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.50974549
23	Huntingtons disease_Homo sapiens_hsa05016	1.47837906
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.44957929
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.43901844
26	Mismatch repair_Homo sapiens_hsa03430	1.34116682
27	Proteasome_Homo sapiens_hsa03050	1.33825618
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30529959
29	Parkinsons disease_Homo sapiens_hsa05012	1.28848412
30	DNA replication_Homo sapiens_hsa03030	1.19950435
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19729152
32	Base excision repair_Homo sapiens_hsa03410	1.19252378
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.16370622
34	Protein export_Homo sapiens_hsa03060	1.15024521
35	Purine metabolism_Homo sapiens_hsa00230	1.12027669
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04683469
37	Sulfur metabolism_Homo sapiens_hsa00920	1.02682375
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01971551
39	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97585033
40	Fatty acid elongation_Homo sapiens_hsa00062	0.96713635
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89600043
42	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.88910037
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82746908
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78905431
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.75521091
46	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.75453267
47	Olfactory transduction_Homo sapiens_hsa04740	0.71945587
48	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.71345033
49	Caffeine metabolism_Homo sapiens_hsa00232	0.68697340
50	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.63156973
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62653705
52	Insulin secretion_Homo sapiens_hsa04911	0.59284599
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58238598
54	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55840866
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.54762626
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54400758
57	Glutathione metabolism_Homo sapiens_hsa00480	0.50970165
58	Nicotine addiction_Homo sapiens_hsa05033	0.50701233
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.49787457
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48777440
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.47794469
62	Phototransduction_Homo sapiens_hsa04744	0.46572373
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.45267190
64	Metabolic pathways_Homo sapiens_hsa01100	0.42264464
65	ABC transporters_Homo sapiens_hsa02010	0.40015795
66	Herpes simplex infection_Homo sapiens_hsa05168	0.39414312
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39156379
68	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38083464
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38031568
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36718281
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.35013397
72	Mineral absorption_Homo sapiens_hsa04978	0.33911088
73	Propanoate metabolism_Homo sapiens_hsa00640	0.32348470
74	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.32089074
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.31531038
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31287510
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.29889123
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.27982894
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27511521
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27342875
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.26808297
82	MicroRNAs in cancer_Homo sapiens_hsa05206	0.26596851
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24455534
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.20687084
85	Serotonergic synapse_Homo sapiens_hsa04726	0.19973242
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.16769272
87	Vibrio cholerae infection_Homo sapiens_hsa05110	0.16557573
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.14331321
89	Alzheimers disease_Homo sapiens_hsa05010	0.14308276
90	Sulfur relay system_Homo sapiens_hsa04122	0.14131529
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.13071003
92	GABAergic synapse_Homo sapiens_hsa04727	0.12731473
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.11640389
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.10083691
95	Morphine addiction_Homo sapiens_hsa05032	0.06960285
96	Circadian rhythm_Homo sapiens_hsa04710	0.06488183
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.06022554
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.04361477
99	One carbon pool by folate_Homo sapiens_hsa00670	0.03757226
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.03007508

PRAMEF19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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