PRAMEF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)5.75659233
2positive regulation of uterine smooth muscle contraction (GO:0070474)5.08917129
3male meiosis I (GO:0007141)5.01229803
4* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)41.5870783
5multicellular organism reproduction (GO:0032504)4.94194137
6regulation of cytokine production involved in inflammatory response (GO:1900015)4.60413164
7regulation of female gonad development (GO:2000194)4.45704000
8meiosis I (GO:0007127)4.37092719
9regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.00411016
10* regulation of retinoic acid receptor signaling pathway (GO:0048385)34.6037338
11regulation of uterine smooth muscle contraction (GO:0070472)3.98749761
12regulation of female receptivity (GO:0045924)3.98078735
13drinking behavior (GO:0042756)3.93970622
14regulation of DNA methylation (GO:0044030)3.87955106
15aggressive behavior (GO:0002118)3.81562680
16transcription from mitochondrial promoter (GO:0006390)3.74020824
17positive regulation of prostaglandin secretion (GO:0032308)3.67948127
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64748441
19protein kinase C signaling (GO:0070528)3.62399083
20hyperosmotic salinity response (GO:0042538)3.60594185
21regulation of penile erection (GO:0060405)3.58071142
22female mating behavior (GO:0060180)3.56975196
23positive regulation of humoral immune response (GO:0002922)3.51683613
24chaperone-mediated protein transport (GO:0072321)3.48845842
25rRNA modification (GO:0000154)3.39608404
26positive regulation of digestive system process (GO:0060456)3.37305068
27reproduction (GO:0000003)3.33143873
28positive regulation of catecholamine secretion (GO:0033605)3.32666253
29maturation of SSU-rRNA (GO:0030490)3.31902800
30negative regulation of digestive system process (GO:0060457)3.19284843
31negative regulation of reproductive process (GO:2000242)3.16400701
32sleep (GO:0030431)3.11327600
33mitotic chromosome condensation (GO:0007076)3.11185571
34ribosome assembly (GO:0042255)3.09716535
35rRNA methylation (GO:0031167)3.09648594
36response to acidic pH (GO:0010447)3.09239968
37regulation of prostaglandin secretion (GO:0032306)3.08900449
38oocyte development (GO:0048599)3.07141225
39binding of sperm to zona pellucida (GO:0007339)2.98594144
40autophagic vacuole assembly (GO:0000045)2.91124835
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.84882428
42cellular response to pH (GO:0071467)2.79851066
43male meiosis (GO:0007140)2.78164790
44glycine transport (GO:0015816)2.78161486
45termination of RNA polymerase III transcription (GO:0006386)2.67578509
46transcription elongation from RNA polymerase III promoter (GO:0006385)2.67578509
47regulation of norepinephrine secretion (GO:0014061)2.64487638
48mitotic metaphase plate congression (GO:0007080)2.61548923
49positive regulation of reproductive process (GO:2000243)2.57926620
50ribosomal small subunit biogenesis (GO:0042274)2.51223751
51translational termination (GO:0006415)2.49517449
52viral transcription (GO:0019083)2.48708308
53maternal behavior (GO:0042711)2.48555881
54ventricular cardiac muscle cell development (GO:0055015)2.47208443
55regulation of mitotic spindle organization (GO:0060236)2.41065819
56chaperone mediated protein folding requiring cofactor (GO:0051085)2.40836692
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.38508074
58sperm-egg recognition (GO:0035036)2.37066996
59regulation of spindle organization (GO:0090224)2.35652641
60N-terminal protein amino acid acetylation (GO:0006474)2.30323362
61telomere maintenance via telomere lengthening (GO:0010833)2.29013036
62single fertilization (GO:0007338)2.24641626
63positive regulation of icosanoid secretion (GO:0032305)2.23602705
64rRNA processing (GO:0006364)2.22371561
65mitochondrial RNA metabolic process (GO:0000959)2.21562602
66parental behavior (GO:0060746)2.20931976
67regulation of G0 to G1 transition (GO:0070316)2.19392009
68protein K6-linked ubiquitination (GO:0085020)2.16955080
69grooming behavior (GO:0007625)2.15364096
70polyamine biosynthetic process (GO:0006596)2.15198484
71ribosome biogenesis (GO:0042254)2.15023102
72translational initiation (GO:0006413)2.14035264
73chromosome condensation (GO:0030261)2.12958352
74rRNA metabolic process (GO:0016072)2.11854165
75positive regulation of renal sodium excretion (GO:0035815)2.11424711
76skeletal muscle tissue regeneration (GO:0043403)2.10573404
77ribonucleoprotein complex biogenesis (GO:0022613)2.09810209
78translational elongation (GO:0006414)2.09193114
79very-low-density lipoprotein particle assembly (GO:0034379)2.09143622
80meiotic cell cycle (GO:0051321)2.07749465
81meiotic nuclear division (GO:0007126)2.06361930
82regulation of RNA export from nucleus (GO:0046831)2.04414508
83positive regulation of fatty acid transport (GO:2000193)2.03022328
84DNA replication initiation (GO:0006270)2.01879194
85negative regulation of RNA splicing (GO:0033119)2.01817279
86positive regulation of chromosome segregation (GO:0051984)2.01359097
87positive regulation of protein homooligomerization (GO:0032464)2.01039979
88regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.00848944
89metaphase plate congression (GO:0051310)2.00813390
90cellular protein complex disassembly (GO:0043624)2.00398791
91pseudouridine synthesis (GO:0001522)1.99274260
92intestinal epithelial cell development (GO:0060576)1.96778707
93response to food (GO:0032094)1.96508640
94regulation of G2/M transition of mitotic cell cycle (GO:0010389)1.96496017
95detection of chemical stimulus involved in sensory perception of taste (GO:0050912)1.95678350
96regulation of urine volume (GO:0035809)1.95656711
97snRNA transcription (GO:0009301)1.94825620
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)1.94322633
99transcription elongation from RNA polymerase II promoter (GO:0006368)1.94108559
100regulation of calcium ion-dependent exocytosis (GO:0017158)1.93080741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_21737748_ChIP-Seq_TLL_Human4.98827008
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.49880260
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.49880260
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.49880260
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06746621
6EZH2_22144423_ChIP-Seq_EOC_Human3.91838746
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77578271
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68923726
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.62625327
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.59893401
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.30255168
12ZNF274_21170338_ChIP-Seq_K562_Hela3.28734438
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.11049887
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92060951
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.79227929
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.76016376
17* ETV1_20927104_ChIP-Seq_GIST48_Human2.67284180
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59804077
19* RBPJ_21746931_ChIP-Seq_IB4_Human2.54726881
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51356248
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43648290
22PHF8_20622853_ChIP-Seq_HELA_Human2.40691805
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.34234598
24GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.30516375
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27071302
26* NFYB_21822215_ChIP-Seq_K562_Human2.23266655
27* TBL1_22424771_ChIP-Seq_293T_Human2.16243117
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15637743
29CDX2_21074721_ChIP-Seq_CACO-2_Mouse2.15263249
30GATA6_21074721_ChIP-Seq_CACO-2_Human2.14328179
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.03670713
32E2F7_22180533_ChIP-Seq_HELA_Human2.01502127
33AR_21909140_ChIP-Seq_LNCAP_Human1.91241152
34HNFA_21074721_ChIP-Seq_CACO-2_Human1.88333209
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84990456
36MYC_18940864_ChIP-ChIP_HL60_Human1.80106507
37VDR_23849224_ChIP-Seq_CD4+_Human1.75330880
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74994979
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73485255
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68559672
41TTF2_22483619_ChIP-Seq_HELA_Human1.65499329
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61657869
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61068122
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57152460
45NFYA_21822215_ChIP-Seq_K562_Human1.56833220
46GABP_19822575_ChIP-Seq_HepG2_Human1.52202178
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51556817
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50889887
49XRN2_22483619_ChIP-Seq_HELA_Human1.42688200
50PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.41184385
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.40252605
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35493234
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30996975
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29908954
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29276804
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29268689
57FOXP3_21729870_ChIP-Seq_TREG_Human1.29095056
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26821212
59NANOG_20526341_ChIP-Seq_ESCs_Human1.24470430
60STAT1_20625510_ChIP-Seq_HELA_Human1.20202111
61KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20011376
62LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19085984
63RAC3_21632823_ChIP-Seq_H3396_Human1.17453437
64CTCF_20526341_ChIP-Seq_ESCs_Human1.13542646
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10927711
66E2F1_20622854_ChIP-Seq_HELA_Human1.08302415
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06312955
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06112563
69TP53_22573176_ChIP-Seq_HFKS_Human1.02454617
70SOX2_21211035_ChIP-Seq_LN229_Human1.02410863
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00355485
72ZNF263_19887448_ChIP-Seq_K562_Human0.99487559
73YY1_22570637_ChIP-Seq_MALME-3M_Human0.97948594
74ELK1_19687146_ChIP-ChIP_HELA_Human0.95308051
75ELK1_22589737_ChIP-Seq_MCF10A_Human0.95084884
76CTCF_21964334_Chip-Seq_Bcells_Human0.92532662
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90409641
78IRF1_19129219_ChIP-ChIP_H3396_Human0.90200653
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88832890
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88053847
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86649454
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86478036
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86368911
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84452406
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83061769
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82650254
87STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82518949
88E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82488201
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82218993
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81705957
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80156978
92P53_21459846_ChIP-Seq_SAOS-2_Human0.79329853
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79013546
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78942991
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78928794
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78295504
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77329737
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76049386
99NCOR_22424771_ChIP-Seq_293T_Human0.75860222
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73280209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.28832997
2MP0001986_abnormal_taste_sensitivity4.92876688
3MP0005423_abnormal_somatic_nervous4.46601754
4MP0006292_abnormal_olfactory_placode4.21486459
5MP0009379_abnormal_foot_pigmentation3.95169670
6MP0003693_abnormal_embryo_hatching3.26109470
7MP0005499_abnormal_olfactory_system2.79026556
8MP0005394_taste/olfaction_phenotype2.79026556
9MP0002127_abnormal_cardiovascular_syste2.72253461
10MP0009840_abnormal_foam_cell2.67882969
11MP0004957_abnormal_blastocyst_morpholog2.57535612
12MP0003646_muscle_fatigue2.54002119
13MP0005410_abnormal_fertilization2.52392235
14MP0003111_abnormal_nucleus_morphology2.45584019
15MP0003077_abnormal_cell_cycle2.37409893
16MP0001929_abnormal_gametogenesis2.33657892
17MP0010307_abnormal_tumor_latency2.30027302
18MP0002210_abnormal_sex_determination2.29426937
19MP0008260_abnormal_autophagy2.28100630
20MP0009333_abnormal_splenocyte_physiolog2.23066994
21MP0005395_other_phenotype2.17407262
22MP0002160_abnormal_reproductive_system2.15073763
23MP0006276_abnormal_autonomic_nervous2.08303041
24MP0002277_abnormal_respiratory_mucosa2.01853071
25MP0008789_abnormal_olfactory_epithelium1.92003392
26MP0001881_abnormal_mammary_gland1.89558376
27MP0008877_abnormal_DNA_methylation1.80113967
28MP0005389_reproductive_system_phenotype1.78085009
29MP0005647_abnormal_sex_gland1.77587965
30MP0003699_abnormal_female_reproductive1.74234707
31MP0010094_abnormal_chromosome_stability1.71347908
32MP0008058_abnormal_DNA_repair1.70992590
33MP0010030_abnormal_orbit_morphology1.70328383
34MP0003283_abnormal_digestive_organ1.64730276
35MP0000653_abnormal_sex_gland1.55873773
36MP0005360_urolithiasis1.48109340
37MP0005451_abnormal_body_composition1.45420671
38MP0001672_abnormal_embryogenesis/_devel1.45011769
39MP0005380_embryogenesis_phenotype1.45011769
40MP0002161_abnormal_fertility/fecundity1.40907834
41MP0002138_abnormal_hepatobiliary_system1.39816333
42MP0003136_yellow_coat_color1.39308497
43MP0000350_abnormal_cell_proliferation1.30991099
44MP0008932_abnormal_embryonic_tissue1.30694376
45MP0008057_abnormal_DNA_replication1.30206340
46MP0003698_abnormal_male_reproductive1.29392942
47MP0005646_abnormal_pituitary_gland1.28977069
48MP0001145_abnormal_male_reproductive1.25853957
49MP0003938_abnormal_ear_development1.25641967
50MP0001730_embryonic_growth_arrest1.21148392
51MP0000372_irregular_coat_pigmentation1.20334055
52MP0004142_abnormal_muscle_tone1.17832510
53MP0001119_abnormal_female_reproductive1.17623567
54MP0001502_abnormal_circadian_rhythm1.14335117
55MP0006036_abnormal_mitochondrial_physio1.14330810
56MP0003984_embryonic_growth_retardation1.13895257
57MP0002088_abnormal_embryonic_growth/wei1.08258628
58MP0003950_abnormal_plasma_membrane1.07445136
59MP0001529_abnormal_vocalization1.06935595
60MP0000462_abnormal_digestive_system1.06931813
61MP0003186_abnormal_redox_activity1.03246259
62MP0001697_abnormal_embryo_size1.02101989
63MP0003195_calcinosis0.97300162
64MP0001666_abnormal_nutrient_absorption0.93588453
65MP0000049_abnormal_middle_ear0.93560659
66MP0001293_anophthalmia0.93272505
67MP0002254_reproductive_system_inflammat0.91480975
68MP0001919_abnormal_reproductive_system0.91396588
69MP0010368_abnormal_lymphatic_system0.91096334
70MP0002233_abnormal_nose_morphology0.89658060
71MP0002796_impaired_skin_barrier0.89501590
72MP0000627_abnormal_mammary_gland0.87941008
73MP0001545_abnormal_hematopoietic_system0.85776922
74MP0005397_hematopoietic_system_phenotyp0.85776922
75MP0005085_abnormal_gallbladder_physiolo0.84689593
76MP0004215_abnormal_myocardial_fiber0.82281212
77MP0000358_abnormal_cell_content/0.81476456
78MP0008995_early_reproductive_senescence0.80272360
79MP0003936_abnormal_reproductive_system0.77871663
80MP0002080_prenatal_lethality0.73662613
81MP0003119_abnormal_digestive_system0.72083223
82MP0004233_abnormal_muscle_weight0.69675039
83MP0002163_abnormal_gland_morphology0.68841515
84MP0002084_abnormal_developmental_patter0.68834849
85MP0002085_abnormal_embryonic_tissue0.67665654
86MP0004019_abnormal_vitamin_homeostasis0.66470905
87MP0003567_abnormal_fetal_cardiomyocyte0.63189121
88MP0000762_abnormal_tongue_morphology0.62964020
89MP0002102_abnormal_ear_morphology0.62859771
90MP0001440_abnormal_grooming_behavior0.62128881
91MP0002873_normal_phenotype0.61364380
92MP0002169_no_abnormal_phenotype0.61124455
93MP0000631_abnormal_neuroendocrine_gland0.60867841
94MP0006035_abnormal_mitochondrial_morpho0.60784029
95MP0002269_muscular_atrophy0.59828802
96MP0005501_abnormal_skin_physiology0.58050963
97MP0001968_abnormal_touch/_nociception0.55816957
98MP0003121_genomic_imprinting0.51621760
99MP0002086_abnormal_extraembryonic_tissu0.49382760
100MP0002736_abnormal_nociception_after0.48849535

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.79914040
2Malnutrition (HP:0004395)6.01102890
3Premature ovarian failure (HP:0008209)4.79705335
4Aplasia/hypoplasia of the uterus (HP:0008684)4.24119365
5Patent foramen ovale (HP:0001655)4.15319581
6Carpal bone hypoplasia (HP:0001498)4.11368926
7Aplasia/Hypoplasia involving the musculature (HP:0001460)3.73782539
8Ileus (HP:0002595)3.73455049
9Sensory axonal neuropathy (HP:0003390)3.69908477
10Infertility (HP:0000789)3.54006967
11Rhinitis (HP:0012384)3.41141353
12Hypoplasia of the uterus (HP:0000013)3.37604102
13Progressive muscle weakness (HP:0003323)3.37134865
14Preauricular pit (HP:0004467)3.33099401
15Periauricular skin pits (HP:0100277)3.33099401
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.32086169
17Hypoplasia of the fovea (HP:0007750)3.32086169
18Hypercortisolism (HP:0001578)3.29572061
19Hypophosphatemic rickets (HP:0004912)3.23614865
20Abnormal pancreas size (HP:0012094)3.22686266
21Birth length less than 3rd percentile (HP:0003561)3.20283976
22Hypergonadotropic hypogonadism (HP:0000815)3.18686888
23Reticulocytopenia (HP:0001896)3.08249933
24Microretrognathia (HP:0000308)3.05547136
25Congenital malformation of the right heart (HP:0011723)3.02887016
26Double outlet right ventricle (HP:0001719)3.02887016
27Dysphonia (HP:0001618)2.92353278
28Osteomalacia (HP:0002749)2.90877152
29Short tibia (HP:0005736)2.88719780
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87881171
31Ureteral duplication (HP:0000073)2.87577602
32Steatorrhea (HP:0002570)2.84962046
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.83942384
34Abnormality of the septum pellucidum (HP:0007375)2.83295163
35Microvesicular hepatic steatosis (HP:0001414)2.80828461
36Abnormal umbilical cord blood vessels (HP:0011403)2.76689310
37Single umbilical artery (HP:0001195)2.76689310
38Abnormality of the fetal cardiovascular system (HP:0010948)2.76689310
39Constricted visual fields (HP:0001133)2.76411894
40Abnormality of the aortic arch (HP:0012303)2.70459173
41Abnormality of cells of the erythroid lineage (HP:0012130)2.65711986
42Muscle stiffness (HP:0003552)2.62458001
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61329304
44Hypoglycemic seizures (HP:0002173)2.60402364
45Anterior segment dysgenesis (HP:0007700)2.60384957
46Multiple enchondromatosis (HP:0005701)2.59962717
47Facial cleft (HP:0002006)2.55295387
48Myopathic facies (HP:0002058)2.52238694
49Abnormality of the fovea (HP:0000493)2.52176333
50Limb dystonia (HP:0002451)2.52169562
51Abnormal number of erythroid precursors (HP:0012131)2.50425851
52Anhidrosis (HP:0000970)2.45738034
53Cleft eyelid (HP:0000625)2.45043300
54Aplasia of the musculature (HP:0100854)2.44881378
55Fat malabsorption (HP:0002630)2.43488133
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.42296570
57Fused cervical vertebrae (HP:0002949)2.41479729
58Myokymia (HP:0002411)2.39154753
59Impaired social interactions (HP:0000735)2.38100592
60Abnormal social behavior (HP:0012433)2.38100592
61Stenosis of the external auditory canal (HP:0000402)2.37139579
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33897427
63Absent thumb (HP:0009777)2.33802799
64Aplasia/hypoplasia of the humerus (HP:0006507)2.33090842
65Glossoptosis (HP:0000162)2.27759839
66Impaired proprioception (HP:0010831)2.27683645
67Absent radius (HP:0003974)2.27570373
68Fibular aplasia (HP:0002990)2.26149161
69Congenital ichthyosiform erythroderma (HP:0007431)2.23840251
70Aplasia involving forearm bones (HP:0009822)2.15071905
71Absent forearm bone (HP:0003953)2.15071905
72Skin pits (HP:0100276)2.14457017
73Metaphyseal dysplasia (HP:0100255)2.11450248
74Glycosuria (HP:0003076)2.05642290
75Abnormality of urine glucose concentration (HP:0011016)2.05642290
76Horseshoe kidney (HP:0000085)2.04609615
77Bony spicule pigmentary retinopathy (HP:0007737)2.03424719
78Breast hypoplasia (HP:0003187)2.03236679
79Concave nail (HP:0001598)2.01287409
80Genu varum (HP:0002970)2.00463879
81Delayed CNS myelination (HP:0002188)2.00450951
82Progressive hearing impairment (HP:0001730)1.99582794
83Absent septum pellucidum (HP:0001331)1.99303517
84Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97875750
85Attenuation of retinal blood vessels (HP:0007843)1.95014589
86Hyperglycemia (HP:0003074)1.94085838
87Hypoplasia of the radius (HP:0002984)1.93549848
88Progressive inability to walk (HP:0002505)1.92856888
89Selective tooth agenesis (HP:0001592)1.92689322
90Aplasia/Hypoplasia of the macula (HP:0008059)1.92392746
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92376822
92Cortical visual impairment (HP:0100704)1.92091843
93Pendular nystagmus (HP:0012043)1.91792680
94Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91610035
95Abnormality of magnesium homeostasis (HP:0004921)1.91278369
96Ragged-red muscle fibers (HP:0003200)1.88077298
97Rickets (HP:0002748)1.87780636
98Choanal stenosis (HP:0000452)1.87549339
99Abnormality of the ileum (HP:0001549)1.87203532
100Meckel diverticulum (HP:0002245)1.87193511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.37473715
2TESK25.51865378
3SRPK14.15243311
4LATS23.84335924
5PBK3.82214432
6TRIM283.27360658
7CDK193.23142102
8STK162.91685529
9BRSK22.73184271
10NEK62.63353437
11BRSK12.47012642
12PLK11.96366389
13PDK21.96341428
14EIF2AK31.90848146
15MARK31.73865866
16NEK21.68627076
17AURKA1.66844778
18ZAK1.59558368
19AURKB1.55289556
20PLK31.37177628
21STK31.33630205
22NME11.30879183
23PKN11.27741634
24PRKCI1.20629543
25PLK41.18705592
26TLK11.14504671
27TAOK31.09110703
28CDK71.07912414
29MAP3K51.07547113
30STK41.07270454
31CHEK11.02412355
32GSK3A1.02224324
33DYRK30.98666333
34TTK0.98414943
35LRRK20.98164257
36CHEK20.95830919
37PAK10.92094978
38ACVR1B0.90707463
39STK240.89779882
40NTRK30.89669082
41MELK0.85337603
42WNK30.78422170
43CSNK2A10.77461122
44CSNK1E0.76618453
45PIM20.76193897
46CDC70.75078802
47CSNK2A20.74505073
48INSRR0.73807083
49MAP3K90.73284011
50STK100.72593787
51WNK10.68502788
52KDR0.67100256
53BMX0.66988248
54PIM10.66879842
55PAK20.66380687
56CDK90.65940274
57AKT20.63313640
58ATR0.59683754
59RAF10.57686485
60WEE10.57481424
61CDK20.56857076
62EIF2AK10.55231859
63MAPK110.49825345
64ABL20.47067195
65CDK10.46860818
66OXSR10.44070127
67STK390.41596445
68FRK0.41213507
69PAK60.40485412
70NME20.38474361
71STK38L0.38340045
72EIF2AK20.36864089
73MAP3K80.34532580
74TESK10.34213455
75ILK0.33406651
76PRKCG0.31487126
77NUAK10.31264321
78LATS10.31115575
79PIK3CG0.27637988
80BMPR1B0.27447122
81MTOR0.26817825
82PRKD10.26689683
83MAPK10.26150195
84ATM0.26099135
85PRKG10.25937398
86GSK3B0.25401430
87WNK40.23016267
88CSNK1A10.22898708
89PINK10.22759014
90CDK80.22246780
91RPS6KA10.22030133
92DMPK0.21520839
93CLK10.21476800
94PRKD20.18449348
95PRKCE0.17498295
96BCKDK0.17429342
97TIE10.17204118
98TAOK20.16714815
99VRK10.16017376
100MAPK140.15477885

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.24195965
2Ribosome_Homo sapiens_hsa030104.86655159
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.79823638
4Folate biosynthesis_Homo sapiens_hsa007904.06038317
5RNA polymerase_Homo sapiens_hsa030204.02292417
6Regulation of autophagy_Homo sapiens_hsa041403.67241447
7mRNA surveillance pathway_Homo sapiens_hsa030153.32765117
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.98921345
9RNA transport_Homo sapiens_hsa030132.79172385
10Cell cycle_Homo sapiens_hsa041102.73644703
11Spliceosome_Homo sapiens_hsa030402.46758142
12Oocyte meiosis_Homo sapiens_hsa041142.16111801
13Taste transduction_Homo sapiens_hsa047422.11787674
14p53 signaling pathway_Homo sapiens_hsa041151.96492168
15Ovarian steroidogenesis_Homo sapiens_hsa049131.91990681
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.84970273
17Pyrimidine metabolism_Homo sapiens_hsa002401.73742110
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52883857
19Steroid biosynthesis_Homo sapiens_hsa001001.34782945
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32816373
21Huntingtons disease_Homo sapiens_hsa050161.32061631
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30208190
23RNA degradation_Homo sapiens_hsa030181.29975995
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29544582
25Cardiac muscle contraction_Homo sapiens_hsa042601.26428680
26DNA replication_Homo sapiens_hsa030301.25273157
27Base excision repair_Homo sapiens_hsa034101.24806175
28Proteasome_Homo sapiens_hsa030501.12269659
29Parkinsons disease_Homo sapiens_hsa050121.11852860
30Mismatch repair_Homo sapiens_hsa034301.11808119
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.10739888
32Sulfur metabolism_Homo sapiens_hsa009201.10265638
33Fanconi anemia pathway_Homo sapiens_hsa034601.04943101
34Homologous recombination_Homo sapiens_hsa034401.04420144
35Fatty acid biosynthesis_Homo sapiens_hsa000611.02593535
36Purine metabolism_Homo sapiens_hsa002300.90584397
37Viral carcinogenesis_Homo sapiens_hsa052030.87555915
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87402483
39Fatty acid elongation_Homo sapiens_hsa000620.87086394
40Epstein-Barr virus infection_Homo sapiens_hsa051690.83127427
41Olfactory transduction_Homo sapiens_hsa047400.80560933
42Nucleotide excision repair_Homo sapiens_hsa034200.76927817
43Oxidative phosphorylation_Homo sapiens_hsa001900.75167371
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68470131
45ABC transporters_Homo sapiens_hsa020100.66183469
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.63005178
47Herpes simplex infection_Homo sapiens_hsa051680.58444269
48Sulfur relay system_Homo sapiens_hsa041220.49881794
49MicroRNAs in cancer_Homo sapiens_hsa052060.48328003
50Inositol phosphate metabolism_Homo sapiens_hsa005620.47152898
51Collecting duct acid secretion_Homo sapiens_hsa049660.47070303
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46482525
53Wnt signaling pathway_Homo sapiens_hsa043100.45711789
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44688723
55Protein digestion and absorption_Homo sapiens_hsa049740.43978335
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.43434020
57Serotonergic synapse_Homo sapiens_hsa047260.42400311
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.38848128
59Synaptic vesicle cycle_Homo sapiens_hsa047210.37455459
60Glutathione metabolism_Homo sapiens_hsa004800.37271820
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36798066
62Protein export_Homo sapiens_hsa030600.36159993
63Mineral absorption_Homo sapiens_hsa049780.34572482
64Caffeine metabolism_Homo sapiens_hsa002320.33993325
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32831691
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32824139
67Arginine and proline metabolism_Homo sapiens_hsa003300.31604398
68Dorso-ventral axis formation_Homo sapiens_hsa043200.30922538
69Hepatitis B_Homo sapiens_hsa051610.30207020
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27147764
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26284227
72Selenocompound metabolism_Homo sapiens_hsa004500.26012402
73Metabolic pathways_Homo sapiens_hsa011000.25895203
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21929652
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21823616
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20459752
77Small cell lung cancer_Homo sapiens_hsa052220.18433842
78Nicotine addiction_Homo sapiens_hsa050330.18318607
79Insulin secretion_Homo sapiens_hsa049110.17662281
80Bile secretion_Homo sapiens_hsa049760.17654183
81Systemic lupus erythematosus_Homo sapiens_hsa053220.16922210
82TGF-beta signaling pathway_Homo sapiens_hsa043500.16756737
83Hippo signaling pathway_Homo sapiens_hsa043900.16106327
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14039022
85AMPK signaling pathway_Homo sapiens_hsa041520.13950905
86Vibrio cholerae infection_Homo sapiens_hsa051100.13498530
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12983159
88Hedgehog signaling pathway_Homo sapiens_hsa043400.11715006
89Acute myeloid leukemia_Homo sapiens_hsa052210.10512821
90Sphingolipid metabolism_Homo sapiens_hsa006000.09709197
91Tight junction_Homo sapiens_hsa045300.08277576
92Morphine addiction_Homo sapiens_hsa050320.07917649
93FoxO signaling pathway_Homo sapiens_hsa040680.07102351
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06657049
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06262471
96GABAergic synapse_Homo sapiens_hsa047270.04812310
97Nitrogen metabolism_Homo sapiens_hsa009100.04108548
98Alzheimers disease_Homo sapiens_hsa050100.02964190
99Alcoholism_Homo sapiens_hsa050340.02552015
100Legionellosis_Homo sapiens_hsa051340.02430909

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