PRAMEF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of retinoic acid receptor signaling pathway (GO:0048385)9.90381993
2negative regulation of protein autophosphorylation (GO:0031953)8.10910608
3negative regulation of interleukin-1 production (GO:0032692)7.17191510
4resolution of meiotic recombination intermediates (GO:0000712)7.03279090
5response to redox state (GO:0051775)6.94452105
6mitotic metaphase plate congression (GO:0007080)6.70337975
7negative regulation of telomere maintenance (GO:0032205)6.63660821
8regulation of acrosome reaction (GO:0060046)6.51369810
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.71630650
10positive regulation of interleukin-1 beta secretion (GO:0050718)5.47270326
11meiotic chromosome segregation (GO:0045132)5.32151019
12positive regulation of uterine smooth muscle contraction (GO:0070474)5.22042610
13positive regulation of interleukin-1 secretion (GO:0050716)5.09382669
14multicellular organism reproduction (GO:0032504)5.03241001
15regulation of female receptivity (GO:0045924)4.93406521
16regulation of spindle organization (GO:0090224)4.92527975
17metaphase plate congression (GO:0051310)4.88604149
18regulation of female gonad development (GO:2000194)4.82852173
19regulation of interleukin-1 beta secretion (GO:0050706)4.80390027
20positive regulation of interleukin-1 beta production (GO:0032731)4.74060127
21regulation of cytokine production involved in inflammatory response (GO:1900015)4.65908728
22mitotic sister chromatid segregation (GO:0000070)4.65825465
23regulation of mitotic spindle organization (GO:0060236)4.65819534
24regulation of interleukin-6 biosynthetic process (GO:0045408)4.61251458
25regulation of meiosis I (GO:0060631)4.58063292
26protein localization to kinetochore (GO:0034501)4.54025464
27negative regulation of hormone biosynthetic process (GO:0032353)4.52869838
28negative regulation of hormone metabolic process (GO:0032351)4.52869838
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.48638803
30protein K6-linked ubiquitination (GO:0085020)4.43378512
31urate metabolic process (GO:0046415)4.37001934
32female mating behavior (GO:0060180)4.26756325
33kinetochore organization (GO:0051383)4.23822818
34regulation of interleukin-1 secretion (GO:0050704)4.21751938
35regulation of telomere maintenance (GO:0032204)4.21730128
36positive regulation of NF-kappaB import into nucleus (GO:0042346)4.21481064
37DNA replication initiation (GO:0006270)4.14771194
38mitotic nuclear envelope disassembly (GO:0007077)4.10742926
39oocyte maturation (GO:0001556)4.09141352
40regulation of gene expression by genetic imprinting (GO:0006349)4.08329107
41kinetochore assembly (GO:0051382)4.04707410
42regulation of uterine smooth muscle contraction (GO:0070472)4.03168510
43regulation of exit from mitosis (GO:0007096)4.02531064
44positive regulation of interleukin-1 production (GO:0032732)3.94858926
45purine nucleobase biosynthetic process (GO:0009113)3.93298306
46regulation of DNA methylation (GO:0044030)3.90148957
47protein kinase C signaling (GO:0070528)3.89603834
48aggressive behavior (GO:0002118)3.89162370
49membrane disassembly (GO:0030397)3.85537041
50nuclear envelope disassembly (GO:0051081)3.85537041
51sister chromatid segregation (GO:0000819)3.82850741
52positive regulation of humoral immune response (GO:0002922)3.78984036
53drinking behavior (GO:0042756)3.78979132
54nuclear pore complex assembly (GO:0051292)3.75669508
55regulation of penile erection (GO:0060405)3.72337801
56nuclear pore organization (GO:0006999)3.67516666
57establishment of chromosome localization (GO:0051303)3.63816195
58inner cell mass cell proliferation (GO:0001833)3.62988909
59regulation of sister chromatid cohesion (GO:0007063)3.61140492
60hyperosmotic salinity response (GO:0042538)3.60412580
61mitotic chromosome condensation (GO:0007076)3.58728615
62protein localization to chromosome, centromeric region (GO:0071459)3.55822268
63positive regulation of prostaglandin secretion (GO:0032308)3.55713787
64dendritic cell migration (GO:0036336)3.51841022
65positive regulation of chromosome segregation (GO:0051984)3.51421104
66snRNA transcription (GO:0009301)3.51137260
67nucleobase biosynthetic process (GO:0046112)3.49544117
68female gonad development (GO:0008585)3.49214884
69synaptonemal complex assembly (GO:0007130)3.49022491
70female gamete generation (GO:0007292)3.47752324
71fibroblast migration (GO:0010761)3.43534466
72maturation of 5.8S rRNA (GO:0000460)3.42360861
73negative regulation of reproductive process (GO:2000242)3.40687818
74carnitine shuttle (GO:0006853)3.39637985
75DNA replication-dependent nucleosome assembly (GO:0006335)3.39271295
76DNA replication-dependent nucleosome organization (GO:0034723)3.39271295
77positive regulation of digestive system process (GO:0060456)3.36085962
78reproduction (GO:0000003)3.35822611
79response to acidic pH (GO:0010447)3.35709109
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.34171098
81attachment of spindle microtubules to kinetochore (GO:0008608)3.33163847
82chromosome segregation (GO:0007059)3.31969513
83regulation of telomere maintenance via telomerase (GO:0032210)3.31528894
84negative regulation of digestive system process (GO:0060457)3.29735870
85sleep (GO:0030431)3.29652376
86CENP-A containing nucleosome assembly (GO:0034080)3.29452360
87chromatin remodeling at centromere (GO:0031055)3.27847440
88meiosis I (GO:0007127)3.27795102
89regulation of chromosome segregation (GO:0051983)3.27128479
90protein localization to chromosome (GO:0034502)3.25610909
91positive regulation of catecholamine secretion (GO:0033605)3.22784587
92glycine transport (GO:0015816)3.21016627
93meiotic cell cycle process (GO:1903046)3.20883916
94regulation of histone H3-K27 methylation (GO:0061085)3.20131591
95poly(A)+ mRNA export from nucleus (GO:0016973)3.19640369
96positive regulation of mitotic sister chromatid separation (GO:1901970)3.19181590
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19181590
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19181590
99oocyte development (GO:0048599)3.17106702
100negative regulation of DNA-templated transcription, elongation (GO:0032785)3.16744485
101negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.16744485
102negative regulation of meiosis (GO:0045835)3.15881642
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15532526
104spindle checkpoint (GO:0031577)3.13404288
105DNA replication-independent nucleosome assembly (GO:0006336)3.07921801
106DNA replication-independent nucleosome organization (GO:0034724)3.07921801
107UV protection (GO:0009650)3.06879535
108histone exchange (GO:0043486)3.05386498
109DNA replication checkpoint (GO:0000076)3.04539279
110microtubule depolymerization (GO:0007019)3.03046861
111maturation of SSU-rRNA (GO:0030490)3.02184129
112meiotic nuclear division (GO:0007126)3.02012641
113cellular response to pH (GO:0071467)3.01948212
114regulation of prostaglandin secretion (GO:0032306)3.00350312
115positive regulation of megakaryocyte differentiation (GO:0045654)2.99214830
116reciprocal DNA recombination (GO:0035825)2.98867728
117reciprocal meiotic recombination (GO:0007131)2.98867728
118transcription from mitochondrial promoter (GO:0006390)2.98754181
119regulation of meiosis (GO:0040020)2.97590820
120regulation of glucocorticoid metabolic process (GO:0031943)2.97515031
121synaptonemal complex organization (GO:0070193)2.97448880
122genetic imprinting (GO:0071514)2.97002835
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.96450393
124male meiosis I (GO:0007141)2.95866903
125negative regulation of interleukin-6 production (GO:0032715)2.95311905
126negative regulation of cytokine secretion (GO:0050710)2.93595089
127nuclear envelope organization (GO:0006998)2.93357940
128rRNA modification (GO:0000154)2.92286999
129male meiosis (GO:0007140)2.89655672
130binding of sperm to zona pellucida (GO:0007339)2.87365217
131positive regulation of reproductive process (GO:2000243)2.76430569
132regulation of norepinephrine secretion (GO:0014061)2.74455076
133rRNA methylation (GO:0031167)2.70953615
134maternal behavior (GO:0042711)2.60479495
135N-terminal protein amino acid acetylation (GO:0006474)2.54918717
136positive regulation of protein homooligomerization (GO:0032464)2.47561165
137autophagic vacuole assembly (GO:0000045)2.46528831
138chaperone-mediated protein transport (GO:0072321)2.46308587
139meiotic cell cycle (GO:0051321)2.43977357
140telomere maintenance via telomere lengthening (GO:0010833)2.40253406
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.37909181
142termination of RNA polymerase III transcription (GO:0006386)2.37909181
143chromosome condensation (GO:0030261)2.36455573
144ribosome assembly (GO:0042255)2.36163861
145ventricular cardiac muscle cell development (GO:0055015)2.33713553
146single fertilization (GO:0007338)2.32577571
147sperm-egg recognition (GO:0035036)2.31281186
148histone H3-K9 demethylation (GO:0033169)2.29239037
149positive regulation of icosanoid secretion (GO:0032305)2.27032980
150parental behavior (GO:0060746)2.26145823
151L-amino acid import (GO:0043092)2.25719328
152chaperone mediated protein folding requiring cofactor (GO:0051085)2.22223452
153regulation of G0 to G1 transition (GO:0070316)2.21737366
154regulation of calcium ion-dependent exocytosis (GO:0017158)2.17124143
155response to food (GO:0032094)2.12436669
156regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.07553959
157positive regulation of renal sodium excretion (GO:0035815)2.05418750
158regulation of reproductive process (GO:2000241)2.04368892
159positive regulation of fatty acid transport (GO:2000193)2.04276902
160regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.03022907
161positive regulation of cAMP-mediated signaling (GO:0043950)2.00973715
162* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)12.8773123
163regulation of MHC class I biosynthetic process (GO:0045343)12.4500453
164piRNA metabolic process (GO:0034587)1.99944646
165muscle organ morphogenesis (GO:0048644)1.95418880
166fertilization (GO:0009566)1.95239725
167detection of chemical stimulus involved in sensory perception of taste (GO:0050912)1.94662605
168nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)1.94507342
169regulation of steroid hormone secretion (GO:2000831)1.93780041
170viral transcription (GO:0019083)1.93467462
171translational termination (GO:0006415)1.93398858
172sensory perception of taste (GO:0050909)1.92627031
173DNA packaging (GO:0006323)1.90142546
174C21-steroid hormone biosynthetic process (GO:0006700)1.89991580
175negative regulation of RNA splicing (GO:0033119)1.87109102
176polyamine biosynthetic process (GO:0006596)1.86619055
177regulation of cell cycle G2/M phase transition (GO:1902749)1.86448607
178grooming behavior (GO:0007625)1.85393301
179cell-cell recognition (GO:0009988)1.84480298
180ribosomal small subunit biogenesis (GO:0042274)1.84393698
181regulation of alternative mRNA splicing, via spliceosome (GO:0000381)1.83812350
182regulation of RNA export from nucleus (GO:0046831)1.82033343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.07066739
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.65429283
3EZH2_22144423_ChIP-Seq_EOC_Human5.65193294
4KAP1_22055183_ChIP-Seq_ESCs_Mouse5.56077114
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse5.23892266
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.18897768
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.18897768
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.18897768
9NOTCH1_21737748_ChIP-Seq_TLL_Human4.90517106
10SALL1_21062744_ChIP-ChIP_HESCs_Human4.59526585
11FOXM1_23109430_ChIP-Seq_U2OS_Human4.22130535
12TP63_17297297_ChIP-ChIP_HaCaT_Human4.06842460
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.78574600
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.65227369
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.57472689
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.53206677
17ZNF274_21170338_ChIP-Seq_K562_Hela3.50082716
18NANOG_18555785_ChIP-Seq_MESCs_Mouse3.27208646
19AR_21909140_ChIP-Seq_LNCAP_Human3.18734370
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05053798
21ETV1_20927104_ChIP-Seq_GIST48_Human3.00582625
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.99703088
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.97950786
24RBPJ_21746931_ChIP-Seq_IB4_Human2.83558622
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.81581600
26TCF3_18692474_ChIP-Seq_MEFs_Mouse2.66834882
27NFYB_21822215_ChIP-Seq_K562_Human2.61512534
28TBL1_22424771_ChIP-Seq_293T_Human2.56898221
29TCF3_18692474_ChIP-Seq_MESCs_Mouse2.55616641
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48781508
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.48717633
32PHF8_20622853_ChIP-Seq_HELA_Human2.45300982
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.37769727
34EST1_17652178_ChIP-ChIP_JURKAT_Human2.37189786
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.36406380
36GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.32594609
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28136907
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25949501
39GATA6_21074721_ChIP-Seq_CACO-2_Human2.20861202
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse2.10852217
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05359739
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.97391897
43NANOG_18692474_ChIP-Seq_MEFs_Mouse1.94621826
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.90738130
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82750555
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.81111432
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80207754
48KAP1_27257070_Chip-Seq_ESCs_Mouse1.78590053
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77399938
50NANOG_18692474_ChIP-Seq_MESCs_Mouse1.75430577
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.71540554
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69526904
53SOX2_18692474_ChIP-Seq_MEFs_Mouse1.67347720
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67024106
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.66728903
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63145268
57NFYA_21822215_ChIP-Seq_K562_Human1.61182585
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58137675
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54291389
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54181202
61NANOG_20526341_ChIP-Seq_ESCs_Human1.53841811
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51115823
63ZNF263_19887448_ChIP-Seq_K562_Human1.48520324
64NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46778014
65VDR_23849224_ChIP-Seq_CD4+_Human1.45991471
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.43399377
67SOX2_18692474_ChIP-Seq_MESCs_Mouse1.42653595
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42526771
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.41262561
70TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.40832943
71STAT1_20625510_ChIP-Seq_HELA_Human1.39277374
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39263275
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.37941806
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36862957
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35297421
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33261255
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32651837
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31989452
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.29503190
80RAC3_21632823_ChIP-Seq_H3396_Human1.28254892
81TTF2_22483619_ChIP-Seq_HELA_Human1.26475706
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22613616
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21776426
84SOX2_21211035_ChIP-Seq_LN229_Human1.21049901
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20833785
86E2F1_20622854_ChIP-Seq_HELA_Human1.20573475
87NANOG_16518401_ChIP-PET_MESCs_Mouse1.19250250
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.18432607
89POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17101146
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16176147
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14951325
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14638797
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12902449
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12755496
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12255095
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10917380
97CTCF_20526341_ChIP-Seq_ESCs_Human1.10557716
98FOXP3_21729870_ChIP-Seq_TREG_Human1.09884690
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07113270
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06950140
101E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06677059
102POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06160961
103GABP_19822575_ChIP-Seq_HepG2_Human1.06138779
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.05857412
105LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02948913
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02431649
107SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01992153
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.00966227
109AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00707369
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.99809198
111FUS_26573619_Chip-Seq_HEK293_Human0.99545169
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99514513
113TP53_22573176_ChIP-Seq_HFKS_Human0.98937324
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98591627
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98403545
116PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97069777
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.96780528
118CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96690963
119KDM2B_26808549_Chip-Seq_REH_Human0.96289769
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96024501
121STAT1_17558387_ChIP-Seq_HELA_Human0.95784008
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94966955
123MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93690761
124P53_21459846_ChIP-Seq_SAOS-2_Human0.91079822
125STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90333257
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89677876
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89550788
128IRF1_19129219_ChIP-ChIP_H3396_Human0.89108138
129XRN2_22483619_ChIP-Seq_HELA_Human0.88839855
130ELK1_19687146_ChIP-ChIP_HELA_Human0.88517442
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88188816
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86698225
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86617004
134HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83804675
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81008896
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80860815
137FOXH1_21741376_ChIP-Seq_ESCs_Human0.80803910
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80541217
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80458673
140MYC_18358816_ChIP-ChIP_MESCs_Mouse0.79635090
141NCOR_22424771_ChIP-Seq_293T_Human0.79303522
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.79045111
143EOMES_21245162_ChIP-Seq_HESCs_Human0.79037488
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78754562
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76502836
146CTCF_21964334_Chip-Seq_Bcells_Human0.76424803
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76204102
148LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76061042
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.74062585
150TP63_19390658_ChIP-ChIP_HaCaT_Human0.73542572
151CIITA_25753668_ChIP-Seq_RAJI_Human0.73468570
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72652558
153NANOG_21062744_ChIP-ChIP_HESCs_Human0.72194247
154HOXB7_26014856_ChIP-Seq_BT474_Human0.71682753
155CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69678768
156RNF2_27304074_Chip-Seq_NSC_Mouse0.69347408
157GATA1_26923725_Chip-Seq_HPCs_Mouse0.69093225
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.66747175
159OCT4_20526341_ChIP-Seq_ESCs_Human0.66487867
160VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.66212395
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.65987930
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.65700907
163SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65601576
164PHF8_20622854_ChIP-Seq_HELA_Human0.65473883
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.64825540
166RBPJ_22232070_ChIP-Seq_NCS_Mouse0.64654946
167HOXB4_20404135_ChIP-ChIP_EML_Mouse0.63662300
168SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.63510725
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.62664913
170KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.62342639
171ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.61826414
172FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.61501140
173MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.60332270
174MYC_18940864_ChIP-ChIP_HL60_Human0.60247109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching7.11658531
2MP0003806_abnormal_nucleotide_metabolis6.27563561
3MP0003787_abnormal_imprinting5.36786511
4MP0001986_abnormal_taste_sensitivity5.29646604
5MP0005423_abnormal_somatic_nervous4.58942583
6MP0009379_abnormal_foot_pigmentation3.93681628
7MP0003718_maternal_effect3.66899168
8MP0010094_abnormal_chromosome_stability3.35094198
9MP0003077_abnormal_cell_cycle3.26783547
10MP0005451_abnormal_body_composition3.24553728
11MP0004957_abnormal_blastocyst_morpholog3.13436423
12MP0005394_taste/olfaction_phenotype3.11879470
13MP0005499_abnormal_olfactory_system3.11879470
14MP0008057_abnormal_DNA_replication2.85616987
15MP0003111_abnormal_nucleus_morphology2.84277869
16MP0003123_paternal_imprinting2.84121642
17MP0005410_abnormal_fertilization2.82914733
18MP0008058_abnormal_DNA_repair2.58706744
19MP0003121_genomic_imprinting2.57756304
20MP0008007_abnormal_cellular_replicative2.55543442
21MP0002127_abnormal_cardiovascular_syste2.55438865
22MP0009840_abnormal_foam_cell2.54300910
23MP0001849_ear_inflammation2.53745720
24MP0005647_abnormal_sex_gland2.36687832
25MP0006276_abnormal_autonomic_nervous2.36577185
26MP0002102_abnormal_ear_morphology2.17323213
27MP0008789_abnormal_olfactory_epithelium2.13459267
28MP0001881_abnormal_mammary_gland2.06731210
29MP0009333_abnormal_splenocyte_physiolog2.03659105
30MP0002277_abnormal_respiratory_mucosa2.01874078
31MP0002638_abnormal_pupillary_reflex2.01796790
32MP0003136_yellow_coat_color2.00617714
33MP0005395_other_phenotype1.90393983
34MP0002210_abnormal_sex_determination1.88808760
35MP0010030_abnormal_orbit_morphology1.84700246
36MP0001730_embryonic_growth_arrest1.81866163
37MP0002138_abnormal_hepatobiliary_system1.78851896
38MP0008877_abnormal_DNA_methylation1.78636811
39MP0000350_abnormal_cell_proliferation1.78471022
40MP0010307_abnormal_tumor_latency1.75410201
41MP0001929_abnormal_gametogenesis1.68898030
42MP0005646_abnormal_pituitary_gland1.68737391
43MP0008932_abnormal_embryonic_tissue1.66863116
44MP0001119_abnormal_female_reproductive1.66746950
45MP0000653_abnormal_sex_gland1.64434694
46MP0005408_hypopigmentation1.58849682
47MP0005266_abnormal_metabolism1.54077497
48MP0002653_abnormal_ependyma_morphology1.53264948
49MP0001145_abnormal_male_reproductive1.51519153
50MP0003699_abnormal_female_reproductive1.47933485
51MP0003011_delayed_dark_adaptation1.47365996
52MP0003879_abnormal_hair_cell1.45482727
53MP0001502_abnormal_circadian_rhythm1.44374309
54MP0000372_irregular_coat_pigmentation1.41186431
55MP0010352_gastrointestinal_tract_polyps1.41016831
56MP0000579_abnormal_nail_morphology1.38079395
57MP0008260_abnormal_autophagy1.37188019
58MP0009697_abnormal_copulation1.33134375
59MP0000462_abnormal_digestive_system1.31461901
60MP0002877_abnormal_melanocyte_morpholog1.28320989
61MP0002084_abnormal_developmental_patter1.23376778
62MP0004142_abnormal_muscle_tone1.20471486
63MP0005380_embryogenesis_phenotype1.19967598
64MP0001672_abnormal_embryogenesis/_devel1.19967598
65MP0002254_reproductive_system_inflammat1.18427006
66MP0003315_abnormal_perineum_morphology1.18177703
67MP0002085_abnormal_embryonic_tissue1.16030587
68MP0003195_calcinosis1.15774706
69MP0002160_abnormal_reproductive_system1.11792503
70MP0010368_abnormal_lymphatic_system1.07154236
71MP0003186_abnormal_redox_activity1.06714962
72MP0002161_abnormal_fertility/fecundity1.04917294
73MP0003698_abnormal_male_reproductive1.00590894
74MP0003632_abnormal_nervous_system0.99802310
75MP0002233_abnormal_nose_morphology0.99206115
76MP0003937_abnormal_limbs/digits/tail_de0.98482571
77MP0004264_abnormal_extraembryonic_tissu0.97826208
78MP0004215_abnormal_myocardial_fiber0.95877009
79MP0002086_abnormal_extraembryonic_tissu0.94567699
80MP0000049_abnormal_middle_ear0.93473969
81MP0001293_anophthalmia0.93249406
82MP0002080_prenatal_lethality0.92848932
83MP0005389_reproductive_system_phenotype0.91441762
84MP0001968_abnormal_touch/_nociception0.91026300
85MP0003984_embryonic_growth_retardation0.90354215
86MP0002249_abnormal_larynx_morphology0.89979751
87MP0006292_abnormal_olfactory_placode0.89797691
88MP0004270_analgesia0.89107974
89MP0003566_abnormal_cell_adhesion0.88051590
90MP0001697_abnormal_embryo_size0.87613915
91MP0005384_cellular_phenotype0.87046174
92MP0001919_abnormal_reproductive_system0.84977927
93MP0002088_abnormal_embryonic_growth/wei0.84011390
94MP0001984_abnormal_olfaction0.83047765
95MP0005621_abnormal_cell_physiology0.82387707
96MP0003866_abnormal_defecation0.80946520
97MP0001666_abnormal_nutrient_absorption0.80935928
98MP0002269_muscular_atrophy0.79895667
99MP0000427_abnormal_hair_cycle0.79464287
100MP0006036_abnormal_mitochondrial_physio0.78999617
101MP0001529_abnormal_vocalization0.78692432
102MP0000627_abnormal_mammary_gland0.78082985
103MP0003646_muscle_fatigue0.77787989
104MP0002139_abnormal_hepatobiliary_system0.77757143
105MP0010234_abnormal_vibrissa_follicle0.77557117
106MP0005023_abnormal_wound_healing0.77024571
107MP0003950_abnormal_plasma_membrane0.75726133
108MP0000516_abnormal_urinary_system0.75499538
109MP0005367_renal/urinary_system_phenotyp0.75499538
110MP0001486_abnormal_startle_reflex0.75362951
111MP0003755_abnormal_palate_morphology0.75156382
112MP0001661_extended_life_span0.74383829
113MP0003119_abnormal_digestive_system0.73440864
114MP0005310_abnormal_salivary_gland0.72589783
115MP0004197_abnormal_fetal_growth/weight/0.72126845
116MP0000631_abnormal_neuroendocrine_gland0.70813167
117MP0000313_abnormal_cell_death0.68903286
118MP0003936_abnormal_reproductive_system0.68783797
119MP0003091_abnormal_cell_migration0.68013425
120MP0005360_urolithiasis0.66626975
121MP0001545_abnormal_hematopoietic_system0.65899780
122MP0005397_hematopoietic_system_phenotyp0.65899780
123MP0000762_abnormal_tongue_morphology0.65713610
124MP0005376_homeostasis/metabolism_phenot0.64556905
125MP0002168_other_aberrant_phenotype0.63650523
126MP0005085_abnormal_gallbladder_physiolo0.63478869
127MP0003221_abnormal_cardiomyocyte_apopto0.62533825
128MP0003941_abnormal_skin_development0.61446357
129MP0003938_abnormal_ear_development0.60996950
130MP0004381_abnormal_hair_follicle0.60899860
131MP0004019_abnormal_vitamin_homeostasis0.60516672
132MP0004233_abnormal_muscle_weight0.59797799
133MP0002873_normal_phenotype0.59584494
134MP0002169_no_abnormal_phenotype0.59267344
135MP0005551_abnormal_eye_electrophysiolog0.58956790
136MP0005076_abnormal_cell_differentiation0.58906138
137MP0001440_abnormal_grooming_behavior0.58809400
138MP0000639_abnormal_adrenal_gland0.58407431
139MP0002019_abnormal_tumor_incidence0.57804448
140MP0008995_early_reproductive_senescence0.57610862
141MP0002163_abnormal_gland_morphology0.57565083
142MP0005197_abnormal_uvea_morphology0.56325308
143MP0000358_abnormal_cell_content/0.54867480
144MP0005508_abnormal_skeleton_morphology0.54331332
145MP0002234_abnormal_pharynx_morphology0.54237121
146MP0002734_abnormal_mechanical_nocicepti0.54063196
147MP0005332_abnormal_amino_acid0.53541198
148MP0006035_abnormal_mitochondrial_morpho0.52141370
149MP0005165_increased_susceptibility_to0.51786334
150MP0001324_abnormal_eye_pigmentation0.48704036

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.95914333
2Birth length less than 3rd percentile (HP:0003561)8.12379579
3Malnutrition (HP:0004395)6.90126883
4Breast hypoplasia (HP:0003187)6.50637964
5Abnormality of the labia minora (HP:0012880)6.21164805
6Premature ovarian failure (HP:0008209)5.58402087
7Esophageal atresia (HP:0002032)5.51352143
8Episodic fever (HP:0001954)4.82574769
9Hypercortisolism (HP:0001578)4.59951484
10Aplasia/hypoplasia of the uterus (HP:0008684)4.59613177
11Autoimmune thrombocytopenia (HP:0001973)4.34538327
12Hypoplasia of the fovea (HP:0007750)4.14332960
13Aplasia/Hypoplasia of the fovea (HP:0008060)4.14332960
14Abnormality of the preputium (HP:0100587)4.11561621
15Meckel diverticulum (HP:0002245)4.06669264
16Infertility (HP:0000789)4.01557711
17Shawl scrotum (HP:0000049)3.99508987
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.99111487
19Rhinitis (HP:0012384)3.96908962
20Aplasia/Hypoplasia of the sternum (HP:0006714)3.85092005
21Carpal bone hypoplasia (HP:0001498)3.81109401
22Absent thumb (HP:0009777)3.80463068
23Abnormality of the ileum (HP:0001549)3.79927774
24Cortical dysplasia (HP:0002539)3.74828028
25Hypoplasia of the uterus (HP:0000013)3.73271434
26Abnormality of chromosome stability (HP:0003220)3.66198349
27Breast aplasia (HP:0100783)3.65378447
28Myokymia (HP:0002411)3.54486833
29Sensory axonal neuropathy (HP:0003390)3.52918604
30Muscle stiffness (HP:0003552)3.51446451
31Patellar aplasia (HP:0006443)3.49115893
32Steatorrhea (HP:0002570)3.45951709
33Hypophosphatemic rickets (HP:0004912)3.42964976
34Preauricular pit (HP:0004467)3.35509990
35Periauricular skin pits (HP:0100277)3.35509990
36Aplasia/Hypoplasia of the breasts (HP:0010311)3.34042328
37Abnormality of DNA repair (HP:0003254)3.33675519
38High pitched voice (HP:0001620)3.32895924
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.32539345
40Long foot (HP:0001833)3.32060177
41Facial hemangioma (HP:0000329)3.30262172
42Tetraparesis (HP:0002273)3.25687055
43Aplasia/Hypoplasia of the patella (HP:0006498)3.21633304
44Abnormality of the septum pellucidum (HP:0007375)3.20446335
45Insulin-resistant diabetes mellitus (HP:0000831)3.18929715
46Gastrointestinal atresia (HP:0002589)3.18741576
47Prostate neoplasm (HP:0100787)3.18279131
48Hypergonadotropic hypogonadism (HP:0000815)3.17758522
49Patent foramen ovale (HP:0001655)3.15879103
50Breech presentation (HP:0001623)3.12952579
51Anterior segment dysgenesis (HP:0007700)3.11477953
52Abnormality of the fovea (HP:0000493)3.11442134
53Decreased subcutaneous fat (HP:0001002)3.10763399
54Autoimmune hemolytic anemia (HP:0001890)3.05606797
55Congenital ichthyosiform erythroderma (HP:0007431)3.01045650
56Dysphonia (HP:0001618)2.99544008
57Abdominal situs inversus (HP:0003363)2.97885804
58Abnormality of abdominal situs (HP:0011620)2.97885804
59Abnormality of cochlea (HP:0000375)2.97540438
60Reticulocytopenia (HP:0001896)2.96352165
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.92469257
62Fat malabsorption (HP:0002630)2.87542228
63Atrioventricular block (HP:0001678)2.85735961
64Spastic diplegia (HP:0001264)2.85389863
65Attenuation of retinal blood vessels (HP:0007843)2.81825405
66Small intestinal stenosis (HP:0012848)2.77665824
67Duodenal stenosis (HP:0100867)2.77665824
68Microretrognathia (HP:0000308)2.75716290
69Clubbing of toes (HP:0100760)2.75207088
70Short tibia (HP:0005736)2.73447285
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.71966237
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68825503
73Adrenal overactivity (HP:0002717)2.64726514
74Impulsivity (HP:0100710)2.64340022
75Constricted visual fields (HP:0001133)2.62950300
76Urticaria (HP:0001025)2.60955130
77Glossoptosis (HP:0000162)2.59923472
78Absent radius (HP:0003974)2.58612858
79Abnormality of the carotid arteries (HP:0005344)2.57881476
80Myelodysplasia (HP:0002863)2.57268136
81Aplasia/Hypoplasia of the macula (HP:0008059)2.55544036
82Facial cleft (HP:0002006)2.55270506
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.53156858
84Slender long bone (HP:0003100)2.51598159
85Multiple enchondromatosis (HP:0005701)2.50176895
86Limb dystonia (HP:0002451)2.48694284
87Pili torti (HP:0003777)2.46428312
88Absent forearm bone (HP:0003953)2.43006534
89Aplasia involving forearm bones (HP:0009822)2.43006534
90Progressive muscle weakness (HP:0003323)2.42214920
91Absent septum pellucidum (HP:0001331)2.40431156
92Ureteral duplication (HP:0000073)2.38800395
93Chromsome breakage (HP:0040012)2.37236699
94Papillary thyroid carcinoma (HP:0002895)2.35467378
95Aplasia/Hypoplasia affecting the retina (HP:0008061)2.34754176
96Progressive sensorineural hearing impairment (HP:0000408)2.34720620
97Aplasia/hypoplasia of the humerus (HP:0006507)2.32915385
98Progressive hearing impairment (HP:0001730)2.31198193
99Hyperglycemia (HP:0003074)2.30203941
100Capillary hemangiomas (HP:0005306)2.28302378
101Pendular nystagmus (HP:0012043)2.27762323
102Triphalangeal thumb (HP:0001199)2.26958921
103Abnormality of the clitoris (HP:0000056)2.26545510
104Aplasia/Hypoplasia involving the musculature (HP:0001460)2.26177238
105Cleft eyelid (HP:0000625)2.25543931
106Delayed CNS myelination (HP:0002188)2.24499560
107Ankle contracture (HP:0006466)2.24103730
108Ectopic kidney (HP:0000086)2.23106637
109Ventricular tachycardia (HP:0004756)2.20760455
110Skin pits (HP:0100276)2.20517090
111Sparse lateral eyebrow (HP:0005338)2.19578751
112Abnormal pancreas size (HP:0012094)2.18588740
113Short humerus (HP:0005792)2.17848916
114Selective tooth agenesis (HP:0001592)2.17345525
115Abnormality of the duodenum (HP:0002246)2.16973799
116Impaired proprioception (HP:0010831)2.14153423
117Abnormality of the aortic arch (HP:0012303)2.12223102
118Midline defect of the nose (HP:0004122)2.12205985
119Cortical visual impairment (HP:0100704)2.10486516
120Anhidrosis (HP:0000970)2.09369616
121Poor coordination (HP:0002370)2.09150942
122High anterior hairline (HP:0009890)2.05987410
123Bony spicule pigmentary retinopathy (HP:0007737)2.04897525
124Microglossia (HP:0000171)2.03987108
125Abnormality of cells of the erythroid lineage (HP:0012130)2.03354369
126Acute lymphatic leukemia (HP:0006721)2.01745237
127Acute myeloid leukemia (HP:0004808)2.01384031
128Central scotoma (HP:0000603)2.01172305
129Stomatitis (HP:0010280)11.5322096
130Gout (HP:0001997)1.99845056
131Abnormal biliary tract morphology (HP:0012440)1.99656342
132Decreased central vision (HP:0007663)1.99406859
133Tongue fasciculations (HP:0001308)1.99124327
134Cone-rod dystrophy (HP:0000548)1.98681796
135Osteomalacia (HP:0002749)1.98522482
136Morphological abnormality of the inner ear (HP:0011390)1.98462851
137Abnormality of lateral ventricle (HP:0030047)1.97725910
138Microvesicular hepatic steatosis (HP:0001414)1.97352739
139Septo-optic dysplasia (HP:0100842)1.96856736
140Aplasia/Hypoplasia of the scapulae (HP:0006713)1.96789921
141Hypoplastic scapulae (HP:0000882)1.96789921
142Clitoromegaly (HP:0000057)1.92363060
143Concave nail (HP:0001598)1.91226642
144Bone marrow hypocellularity (HP:0005528)1.90334969
145Thin ribs (HP:0000883)1.90232809
146Nausea (HP:0002018)1.90122697
147Thyroid-stimulating hormone excess (HP:0002925)1.89085437
148Rhabdomyolysis (HP:0003201)1.88305907
149Testicular atrophy (HP:0000029)1.87041638
150Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86852011
151Atresia of the external auditory canal (HP:0000413)1.86704953
152Horizontal nystagmus (HP:0000666)1.86625061
153Abnormality of the labia (HP:0000058)1.86386824
154Abnormal number of erythroid precursors (HP:0012131)1.85737567
155Sparse eyelashes (HP:0000653)1.85313222
156Mitral stenosis (HP:0001718)1.84937758
157Areflexia of lower limbs (HP:0002522)1.84820328
158Poor eye contact (HP:0000817)1.84541281
159Fibular aplasia (HP:0002990)1.82974601
160Cafe-au-lait spot (HP:0000957)1.82859635
161Abnormality of subcutaneous fat tissue (HP:0001001)1.82648070
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81261255
163Bradycardia (HP:0001662)1.80297399
164Abnormality of purine metabolism (HP:0004352)1.80182820
165Abnormality of the anterior horn cell (HP:0006802)1.80076872
166Degeneration of anterior horn cells (HP:0002398)1.80076872
167Muscle fibrillation (HP:0010546)1.79710636
168Scanning speech (HP:0002168)1.75574441
169Arteriovenous malformation (HP:0100026)1.72542764
170Secondary amenorrhea (HP:0000869)1.71785173
171Supernumerary spleens (HP:0009799)1.71415602
172Microtia (HP:0008551)1.68034184
173Oligodactyly (hands) (HP:0001180)1.67662608
174Abnormal delivery (HP:0001787)1.67592495
175Long eyelashes (HP:0000527)1.66906369
176Heart block (HP:0012722)1.65839703
177Cerebral hypomyelination (HP:0006808)1.65752320
178Wrist flexion contracture (HP:0001239)1.65691320
179Fused cervical vertebrae (HP:0002949)1.65496835
180Abnormality of the prostate (HP:0008775)1.65368893
181Horseshoe kidney (HP:0000085)1.63628938
182Cystic hygroma (HP:0000476)1.63542681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.14693261
2RPS6KA44.67229503
3CDK194.07884506
4LATS23.68358522
5STK163.15593842
6CDC73.11335399
7TRIM283.10337885
8MUSK3.07664513
9CDK32.88883773
10EEF2K2.58907433
11BRSK22.49900780
12ERBB42.42586737
13STK38L2.35567777
14KSR22.34514428
15LATS12.31410470
16EIF2AK32.29178751
17WEE12.08802705
18EIF2AK12.07576961
19PAK62.03475688
20RAF12.02964506
21PDK41.99416507
22PDK31.99416507
23PLK11.90352258
24STK381.88515870
25CDK121.87330502
26BRAF1.85473438
27NEK21.85118357
28AKT31.75038583
29BRSK11.68924624
30PLK31.68328082
31TTK1.68288163
32DYRK31.66935139
33PDK21.66933145
34IRAK31.64669194
35STK41.63206601
36ZAK1.61278274
37MAP3K91.50987143
38AURKB1.49169265
39MAP3K61.45672960
40BUB11.42466021
41NEK11.41685454
42MAPKAPK31.38605061
43RPS6KB21.36311986
44PASK1.33712645
45VRK11.31528596
46ARAF1.26131220
47TLK11.20531920
48TRPM71.19904513
49LRRK21.15977041
50PKN11.15868517
51WNK11.15037770
52PLK41.14598743
53PIM21.13034857
54GSK3A1.10808026
55MAP3K51.09654685
56AURKA1.06069260
57KSR11.03493188
58CHEK21.03387243
59STK31.00715832
60WNK30.96665658
61SRPK10.95259011
62ABL20.94698067
63NTRK30.94663751
64CHEK10.94085752
65CAMK10.91507390
66SCYL20.90331289
67MELK0.89245773
68ADRBK20.88170029
69PBK0.88093147
70TAOK30.72235320
71STK240.71869014
72CDK20.71466662
73PAK30.68026426
74NEK60.66108898
75ATR0.65179211
76STK100.65080043
77ATM0.64887892
78PIM10.64777060
79KDR0.61718915
80PAK20.60121261
81MKNK20.58729240
82CAMK2G0.57182236
83AKT20.56595343
84MARK20.55938209
85CDK10.52030743
86CSNK1D0.51311411
87CDK90.51307469
88PAK10.50943088
89MAPK110.50444272
90MAPK100.49264451
91EIF2AK20.48541221
92RPS6KA50.48478119
93PRKAA10.48208794
94CLK10.44585970
95PRKCI0.44245727
96TAOK10.44131415
97FGR0.43788802
98ALK0.43177694
99NTRK10.42126636
100PIK3CG0.42069388
101MAP3K80.41170411
102MST40.40282216
103CDK70.40274016
104TSSK60.37192955
105OXSR10.37029256
106BRD40.36980707
107CSNK2A20.36872548
108MARK30.36833837
109TAOK20.36595535
110PRKD10.33870374
111PRKG10.33657384
112WNK40.32051861
113CDK11A0.31572196
114EPHA20.31523846
115PRKCG0.31509227
116ACVR1B0.30637915
117GSK3B0.30398631
118PRKAA20.30137812
119CSNK1E0.27817552
120PRKCE0.27616945
121PINK10.27011115
122ADRBK10.24722949
123CSNK2A10.24613834
124CAMKK10.23994095
125CDK40.23864400
126NME10.23558769
127MAPK10.22954646
128LMTK20.22454643
129PLK20.22048543
130MAPKAPK50.22033664
131MAPK140.22005997
132PRKDC0.21726618
133MKNK10.21566166
134BMPR1B0.21476727
135CDK150.21367192
136DYRK20.20192148
137MAP3K130.19823336
138PRKD20.19539899
139DMPK0.19355132
140CSNK1A10.18438423
141RPS6KA10.18393241
142MTOR0.18257075
143MET0.18138087
144BMX0.17714511
145STK390.17645021
146PDK10.15381638
147PRKACA0.14670178
148GRK50.14579249

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.88458778
2Cell cycle_Homo sapiens_hsa041103.73513348
3Regulation of autophagy_Homo sapiens_hsa041403.51143631
4Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002503.50707944
5Arginine biosynthesis_Homo sapiens_hsa002203.24611781
6DNA replication_Homo sapiens_hsa030303.15555001
7Mismatch repair_Homo sapiens_hsa034303.15149664
8Nucleotide excision repair_Homo sapiens_hsa034203.09682668
9Fanconi anemia pathway_Homo sapiens_hsa034603.04943520
10Biosynthesis of amino acids_Homo sapiens_hsa012302.91033014
11RNA transport_Homo sapiens_hsa030132.88142660
12Non-homologous end-joining_Homo sapiens_hsa034502.82714881
13One carbon pool by folate_Homo sapiens_hsa006702.82609441
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.76529694
15Taste transduction_Homo sapiens_hsa047422.67077104
16Vitamin B6 metabolism_Homo sapiens_hsa007502.65038515
17RNA degradation_Homo sapiens_hsa030182.50298971
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40836346
19Pentose phosphate pathway_Homo sapiens_hsa000302.31697079
20Homologous recombination_Homo sapiens_hsa034402.31351327
21RNA polymerase_Homo sapiens_hsa030202.29251888
22Basal transcription factors_Homo sapiens_hsa030222.12866982
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12668003
24p53 signaling pathway_Homo sapiens_hsa041151.96192427
25Nitrogen metabolism_Homo sapiens_hsa009101.82178404
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78325146
27Spliceosome_Homo sapiens_hsa030401.52762747
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.48397752
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48214333
30Pyrimidine metabolism_Homo sapiens_hsa002401.40806509
31Arginine and proline metabolism_Homo sapiens_hsa003301.37692436
32Carbon metabolism_Homo sapiens_hsa012001.36205216
33Oocyte meiosis_Homo sapiens_hsa041141.36038922
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34042231
35Olfactory transduction_Homo sapiens_hsa047401.33908845
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.29963866
37Pyruvate metabolism_Homo sapiens_hsa006201.24721418
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23434550
39mRNA surveillance pathway_Homo sapiens_hsa030151.19774139
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17186243
41Fatty acid biosynthesis_Homo sapiens_hsa000611.16542723
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12093549
43Cardiac muscle contraction_Homo sapiens_hsa042601.11280143
44Sulfur metabolism_Homo sapiens_hsa009201.05459179
45Huntingtons disease_Homo sapiens_hsa050161.04885490
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99293999
47Selenocompound metabolism_Homo sapiens_hsa004500.96344380
48Propanoate metabolism_Homo sapiens_hsa006400.93364904
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92956489
50Viral carcinogenesis_Homo sapiens_hsa052030.91473265
51Purine metabolism_Homo sapiens_hsa002300.85783945
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83333210
53Steroid biosynthesis_Homo sapiens_hsa001000.83022181
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82617522
55Base excision repair_Homo sapiens_hsa034100.82073470
56Dorso-ventral axis formation_Homo sapiens_hsa043200.80110292
57TGF-beta signaling pathway_Homo sapiens_hsa043500.77480976
58ABC transporters_Homo sapiens_hsa020100.76488329
59Fatty acid elongation_Homo sapiens_hsa000620.72450444
60Serotonergic synapse_Homo sapiens_hsa047260.70542914
61Glutathione metabolism_Homo sapiens_hsa004800.69585097
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69228166
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68806654
64MicroRNAs in cancer_Homo sapiens_hsa052060.68541340
65Herpes simplex infection_Homo sapiens_hsa051680.68221357
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66236768
67Parkinsons disease_Homo sapiens_hsa050120.65559118
68Histidine metabolism_Homo sapiens_hsa003400.64909494
69Small cell lung cancer_Homo sapiens_hsa052220.64562415
70Ovarian steroidogenesis_Homo sapiens_hsa049130.64187227
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63778238
72Caffeine metabolism_Homo sapiens_hsa002320.63202346
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61474046
74Fatty acid degradation_Homo sapiens_hsa000710.57845010
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56070837
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.55856086
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55207204
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55074031
79Tyrosine metabolism_Homo sapiens_hsa003500.54701855
80Thyroid cancer_Homo sapiens_hsa052160.53118921
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52929894
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52891967
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52555596
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51892715
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.51624694
86Wnt signaling pathway_Homo sapiens_hsa043100.51485441
87Morphine addiction_Homo sapiens_hsa050320.50556475
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50292241
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50169136
90Epstein-Barr virus infection_Homo sapiens_hsa051690.49419089
91Folate biosynthesis_Homo sapiens_hsa007900.49053501
92Ether lipid metabolism_Homo sapiens_hsa005650.48598288
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48337094
94Lysine degradation_Homo sapiens_hsa003100.47948863
95Insulin secretion_Homo sapiens_hsa049110.47549530
96Linoleic acid metabolism_Homo sapiens_hsa005910.47301853
97Inositol phosphate metabolism_Homo sapiens_hsa005620.44820919
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44617086
99Systemic lupus erythematosus_Homo sapiens_hsa053220.44153003
100Protein digestion and absorption_Homo sapiens_hsa049740.42004762
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40197931
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40118597
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.38423102
104Nicotine addiction_Homo sapiens_hsa050330.37741152
105Hepatitis B_Homo sapiens_hsa051610.37465384
106Chemical carcinogenesis_Homo sapiens_hsa052040.36907171
107Bladder cancer_Homo sapiens_hsa052190.36455798
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36235246
109Glucagon signaling pathway_Homo sapiens_hsa049220.36180666
110Proteasome_Homo sapiens_hsa030500.36153749
111Adherens junction_Homo sapiens_hsa045200.35816230
112GABAergic synapse_Homo sapiens_hsa047270.35339232
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32346843
114Synaptic vesicle cycle_Homo sapiens_hsa047210.32274030
115Tryptophan metabolism_Homo sapiens_hsa003800.31601164
116Hippo signaling pathway_Homo sapiens_hsa043900.30251343
117Tight junction_Homo sapiens_hsa045300.29199609
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28873552
119Mineral absorption_Homo sapiens_hsa049780.28780545
120Pancreatic cancer_Homo sapiens_hsa052120.28491464
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28135464
122Alcoholism_Homo sapiens_hsa050340.27994560
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.27781903
124Acute myeloid leukemia_Homo sapiens_hsa052210.25617842
125AMPK signaling pathway_Homo sapiens_hsa041520.25289036
126Cocaine addiction_Homo sapiens_hsa050300.23954929
127Circadian rhythm_Homo sapiens_hsa047100.23046208
128Amoebiasis_Homo sapiens_hsa051460.21253727
129beta-Alanine metabolism_Homo sapiens_hsa004100.21127157
130Choline metabolism in cancer_Homo sapiens_hsa052310.20187688
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20022707
132Metabolic pathways_Homo sapiens_hsa011000.19773558
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19563883
134Butanoate metabolism_Homo sapiens_hsa006500.18940728
135Other glycan degradation_Homo sapiens_hsa005110.18533564
136Legionellosis_Homo sapiens_hsa051340.18073252
137Colorectal cancer_Homo sapiens_hsa052100.17424168
138Galactose metabolism_Homo sapiens_hsa000520.16875266
139Complement and coagulation cascades_Homo sapiens_hsa046100.16523516
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14955563
141Arachidonic acid metabolism_Homo sapiens_hsa005900.14718984
142Calcium signaling pathway_Homo sapiens_hsa040200.14529511
143Pancreatic secretion_Homo sapiens_hsa049720.14477468
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13537977
145Renal cell carcinoma_Homo sapiens_hsa052110.12843324
146FoxO signaling pathway_Homo sapiens_hsa040680.12456943
147Hedgehog signaling pathway_Homo sapiens_hsa043400.11038088
148Influenza A_Homo sapiens_hsa051640.10769828
149Bile secretion_Homo sapiens_hsa049760.10578377
150Amphetamine addiction_Homo sapiens_hsa050310.10431855
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09755124
152Circadian entrainment_Homo sapiens_hsa047130.09745841
153Protein export_Homo sapiens_hsa030600.09139967
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08065283
155Salivary secretion_Homo sapiens_hsa049700.07823591
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05851246
157Sphingolipid metabolism_Homo sapiens_hsa006000.05554124
158Oxytocin signaling pathway_Homo sapiens_hsa049210.01284482
159Retinol metabolism_Homo sapiens_hsa00830-0.0043769
160Pathways in cancer_Homo sapiens_hsa05200-0.0003279

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