PRAMEF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)7.75386592
2mitotic metaphase plate congression (GO:0007080)7.59436729
3* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.74300227
4female mating behavior (GO:0060180)6.74013787
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.60402749
6regulation of meiosis I (GO:0060631)6.23343545
7metaphase plate congression (GO:0051310)5.75211008
8regulation of acrosome reaction (GO:0060046)5.36776232
9regulation of spindle organization (GO:0090224)5.30048944
10regulation of exit from mitosis (GO:0007096)5.28096627
11meiosis I (GO:0007127)5.25646749
12oocyte maturation (GO:0001556)5.22784225
13negative regulation of hormone metabolic process (GO:0032351)5.21589832
14negative regulation of hormone biosynthetic process (GO:0032353)5.21589832
15maturation of 5.8S rRNA (GO:0000460)5.11649216
16* regulation of retinoic acid receptor signaling pathway (GO:0048385)5.05779844
17positive regulation of uterine smooth muscle contraction (GO:0070474)4.94168449
18male meiosis I (GO:0007141)4.90972730
19protein localization to kinetochore (GO:0034501)4.86613853
20establishment of chromosome localization (GO:0051303)4.74567496
21DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.65777022
22monoubiquitinated protein deubiquitination (GO:0035520)4.64510759
23regulation of mitotic spindle organization (GO:0060236)4.60575290
24multicellular organism reproduction (GO:0032504)4.58647376
25DNA damage response, signal transduction resulting in transcription (GO:0042772)4.52727452
26positive regulation of chromosome segregation (GO:0051984)4.46922577
27DNA replication checkpoint (GO:0000076)4.41884566
28microtubule depolymerization (GO:0007019)4.36054947
29positive regulation of protein homooligomerization (GO:0032464)4.35075115
30resolution of meiotic recombination intermediates (GO:0000712)4.32508608
31meiotic chromosome segregation (GO:0045132)4.28613322
32protein localization to chromosome, centromeric region (GO:0071459)4.28420360
33regulation of transcription from RNA polymerase I promoter (GO:0006356)4.24660208
34regulation of female gonad development (GO:2000194)4.22726808
35mitotic sister chromatid segregation (GO:0000070)4.19637385
36regulation of DNA methylation (GO:0044030)4.16269408
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.11105393
38rRNA modification (GO:0000154)4.10226615
39purine nucleobase biosynthetic process (GO:0009113)4.07055565
40regulation of sister chromatid cohesion (GO:0007063)4.00245164
41regulation of establishment of cell polarity (GO:2000114)3.97837451
42regulation of glucocorticoid metabolic process (GO:0031943)3.96786149
43regulation of meiosis (GO:0040020)3.95952323
44histone H2A monoubiquitination (GO:0035518)3.92472907
45protein localization to chromosome (GO:0034502)3.91762554
46transcription from mitochondrial promoter (GO:0006390)3.91716094
47female gonad development (GO:0008585)3.87920352
48inner cell mass cell proliferation (GO:0001833)3.86934680
49histone exchange (GO:0043486)3.86933866
50regulation of chromosome segregation (GO:0051983)3.84139574
51mitotic chromosome condensation (GO:0007076)3.83209495
52spindle checkpoint (GO:0031577)3.80134244
53regulation of histone H3-K27 methylation (GO:0061085)3.80089356
54CENP-A containing nucleosome assembly (GO:0034080)3.79402927
55regulation of uterine smooth muscle contraction (GO:0070472)3.76105590
56DNA damage induced protein phosphorylation (GO:0006975)3.74768245
57DNA replication-independent nucleosome assembly (GO:0006336)3.74724250
58DNA replication-independent nucleosome organization (GO:0034724)3.74724250
59negative regulation of meiosis (GO:0045835)3.65066420
60rRNA methylation (GO:0031167)3.64672936
61regulation of cytokine production involved in inflammatory response (GO:1900015)3.63044470
62chromosome segregation (GO:0007059)3.62821431
63meiotic nuclear division (GO:0007126)3.61306536
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59869195
65positive regulation of megakaryocyte differentiation (GO:0045654)3.59721866
66regulation of telomere maintenance via telomerase (GO:0032210)3.58968854
67meiotic cell cycle process (GO:1903046)3.58194032
68chromatin remodeling at centromere (GO:0031055)3.56656861
69nuclear pore complex assembly (GO:0051292)3.56506622
70mitotic nuclear envelope disassembly (GO:0007077)3.56148451
71kinetochore assembly (GO:0051382)3.56120956
72aggressive behavior (GO:0002118)3.51059795
73female gamete generation (GO:0007292)3.50799986
74negative regulation of keratinocyte proliferation (GO:0010839)3.50260465
75nucleobase biosynthetic process (GO:0046112)3.48812811
76ribosome assembly (GO:0042255)3.48408187
77synaptonemal complex assembly (GO:0007130)3.41902162
78negative regulation of telomere maintenance (GO:0032205)3.40593002
79RNA capping (GO:0036260)3.40201779
807-methylguanosine RNA capping (GO:0009452)3.40201779
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.39409237
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.39409237
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.39409237
84male meiosis (GO:0007140)3.39014361
85piRNA metabolic process (GO:0034587)3.38554269
867-methylguanosine mRNA capping (GO:0006370)3.38139315
87drinking behavior (GO:0042756)3.37975267
88positive regulation of prostaglandin secretion (GO:0032308)3.35913884
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.35201265
90regulation of establishment or maintenance of cell polarity (GO:0032878)3.34071713
91ribosome biogenesis (GO:0042254)3.33647057
92nuclear envelope disassembly (GO:0051081)3.32443520
93membrane disassembly (GO:0030397)3.32443520
94negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.30961580
95negative regulation of DNA-templated transcription, elongation (GO:0032785)3.30961580
96snRNA transcription (GO:0009301)3.29492052
97reciprocal DNA recombination (GO:0035825)3.28902179
98reciprocal meiotic recombination (GO:0007131)3.28902179
99sister chromatid segregation (GO:0000819)3.28448574
100regulation of meiotic cell cycle (GO:0051445)3.22595638
101nuclear pore organization (GO:0006999)3.20365490
102regulation of penile erection (GO:0060405)3.16708419
103sister chromatid cohesion (GO:0007062)3.15881647
104regulation of RNA export from nucleus (GO:0046831)3.15087818
105regulation of spindle checkpoint (GO:0090231)3.13391269
106regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12847545
107regulation of RIG-I signaling pathway (GO:0039535)3.11845056
108response to acidic pH (GO:0010447)3.11349408
109mitotic spindle checkpoint (GO:0071174)3.11281459
110histone H2A ubiquitination (GO:0033522)3.10332572
111negative regulation of DNA-dependent DNA replication (GO:2000104)3.08645969
112attachment of spindle microtubules to kinetochore (GO:0008608)3.08466341
113transcription elongation from RNA polymerase II promoter (GO:0006368)3.08363778
114positive regulation of catecholamine secretion (GO:0033605)3.07851548
115hyperosmotic salinity response (GO:0042538)3.07633883
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06325134
117reproduction (GO:0000003)3.05121337
118kinetochore organization (GO:0051383)3.04725864
119regulation of transforming growth factor beta2 production (GO:0032909)3.04517866
120positive regulation of humoral immune response (GO:0002922)3.04214253
121protein kinase C signaling (GO:0070528)3.00411409
122cellular response to pH (GO:0071467)2.94558677
123autophagic vacuole assembly (GO:0000045)2.91986226
124positive regulation of digestive system process (GO:0060456)2.89311318
125N-terminal protein amino acid acetylation (GO:0006474)2.88243056
126negative regulation of digestive system process (GO:0060457)2.84777407
127negative regulation of reproductive process (GO:2000242)2.84649224
128sleep (GO:0030431)2.83907887
129regulation of prostaglandin secretion (GO:0032306)2.81174548
130glycine transport (GO:0015816)2.78533644
131maternal behavior (GO:0042711)2.72517726
132multicellular organismal reproductive behavior (GO:0033057)2.71196088
133maturation of SSU-rRNA (GO:0030490)2.69061268
134ventricular cardiac muscle cell development (GO:0055015)2.68344144
135oocyte development (GO:0048599)2.67175752
136chaperone-mediated protein transport (GO:0072321)2.60823224
137meiotic cell cycle (GO:0051321)2.60275413
138activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.59956905
139detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.56023089
140positive regulation of reproductive process (GO:2000243)2.55915707
141protein K6-linked ubiquitination (GO:0085020)2.52272627
142binding of sperm to zona pellucida (GO:0007339)2.52169001
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47086709
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.46787502
145termination of RNA polymerase III transcription (GO:0006386)2.46787502
146intestinal epithelial cell development (GO:0060576)2.45970218
147chaperone mediated protein folding requiring cofactor (GO:0051085)2.45959784
148positive regulation of cAMP-mediated signaling (GO:0043950)2.39512450
149parental behavior (GO:0060746)2.35510835
150skeletal muscle tissue regeneration (GO:0043403)2.34233912
151regulation of G0 to G1 transition (GO:0070316)2.33474138
152single fertilization (GO:0007338)2.23257987
153regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.17938588
154phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.15887893
155telomere maintenance via telomere lengthening (GO:0010833)2.13920853
156regulation of norepinephrine secretion (GO:0014061)2.10620444
157mitochondrial RNA metabolic process (GO:0000959)2.10268262
158positive regulation of icosanoid secretion (GO:0032305)2.09936308
159regulation of protein homooligomerization (GO:0032462)2.09628423
160sperm-egg recognition (GO:0035036)2.08490630
161polyamine biosynthetic process (GO:0006596)2.08403418
162positive regulation of protein oligomerization (GO:0032461)2.07667663
163chromosome condensation (GO:0030261)2.07016282
164regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.05542452
165histone H3-K9 demethylation (GO:0033169)2.03350006
166regulation of cell cycle G2/M phase transition (GO:1902749)2.02810830
167response to UV-C (GO:0010225)2.00965932
168sensory perception of taste (GO:0050909)1.99206870
169rRNA processing (GO:0006364)1.94963966
170fertilization (GO:0009566)1.94573282
171positive regulation of cytokinesis (GO:0032467)1.92897043
172response to food (GO:0032094)1.92640077
173positive regulation of fatty acid transport (GO:2000193)1.90175021
174fusion of sperm to egg plasma membrane (GO:0007342)1.89172428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.02660200
2E2F7_22180533_ChIP-Seq_HELA_Human7.47723776
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.61264917
4EZH2_22144423_ChIP-Seq_EOC_Human5.24982429
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.23341391
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.23341391
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.23341391
8NOTCH1_21737748_ChIP-Seq_TLL_Human4.92760802
9* KAP1_22055183_ChIP-Seq_ESCs_Mouse4.65133097
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70300255
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.60734653
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58431417
13ZNF274_21170338_ChIP-Seq_K562_Hela3.47515851
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.44337822
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40656956
16SALL1_21062744_ChIP-ChIP_HESCs_Human3.29765104
17E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20171402
18AR_21909140_ChIP-Seq_LNCAP_Human3.13179013
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65960378
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.54417850
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45465662
22* ETV1_20927104_ChIP-Seq_GIST48_Human2.42400707
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.40723932
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36110559
25NFYB_21822215_ChIP-Seq_K562_Human2.27951287
26* RBPJ_21746931_ChIP-Seq_IB4_Human2.25329849
27PHF8_20622853_ChIP-Seq_HELA_Human2.24970609
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.11042007
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.08877524
30GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.99244002
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96419388
32* TBL1_22424771_ChIP-Seq_293T_Human1.95996104
33CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.83940751
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79845710
35* GATA6_21074721_ChIP-Seq_CACO-2_Human1.73473898
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.73039467
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71708032
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.71119295
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70853636
40HNFA_21074721_ChIP-Seq_CACO-2_Human1.70689358
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69162380
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66742922
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64983932
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.63343714
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.63009501
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54528644
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.53087649
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50934955
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.49604500
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49527291
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47265360
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46374673
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43436915
54NFYA_21822215_ChIP-Seq_K562_Human1.42458576
55KAP1_27257070_Chip-Seq_ESCs_Mouse1.41594566
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37454374
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34330548
58TTF2_22483619_ChIP-Seq_HELA_Human1.33706221
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32389630
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27571516
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26474144
62TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26210796
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26089899
64NANOG_20526341_ChIP-Seq_ESCs_Human1.25718910
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25564365
66RAC3_21632823_ChIP-Seq_H3396_Human1.24585611
67VDR_23849224_ChIP-Seq_CD4+_Human1.23873735
68TP53_22573176_ChIP-Seq_HFKS_Human1.22876601
69STAT1_20625510_ChIP-Seq_HELA_Human1.22560594
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.20358759
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19599532
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18824786
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18034398
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16787954
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14646656
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11838929
77MYC_18940864_ChIP-ChIP_HL60_Human1.11438379
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11144450
79XRN2_22483619_ChIP-Seq_HELA_Human1.08855019
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08812746
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07955533
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06718154
83LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06484367
84E2F1_20622854_ChIP-Seq_HELA_Human1.05845442
85RNF2_27304074_Chip-Seq_NSC_Mouse1.05132007
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04354828
87* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04141862
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03238057
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02732141
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00467298
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99812987
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.99702558
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98045164
94STAT1_17558387_ChIP-Seq_HELA_Human0.97901026
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97316170
96SOX2_21211035_ChIP-Seq_LN229_Human0.95538845
97HOXB7_26014856_ChIP-Seq_BT474_Human0.95326290
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95114191
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94252765
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.93599589
101FOXH1_21741376_ChIP-Seq_ESCs_Human0.93564179
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92374994
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91894031
104GATA3_21867929_ChIP-Seq_TH1_Mouse0.91716976
105FUS_26573619_Chip-Seq_HEK293_Human0.91288056
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91098455
107ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90986071
108CTCF_20526341_ChIP-Seq_ESCs_Human0.90428360
109P53_21459846_ChIP-Seq_SAOS-2_Human0.90411703
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89445604
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87949370
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.87730707
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87396600
114NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86786958
115E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86587655
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86536127
117NCOR_22424771_ChIP-Seq_293T_Human0.84823027
118GABP_19822575_ChIP-Seq_HepG2_Human0.84743563
119KDM5A_27292631_Chip-Seq_BREAST_Human0.84740486
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84595744
121CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84550034
122STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83018340
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82894761
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82889513
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82804740
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81872817
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81369109
128IRF1_19129219_ChIP-ChIP_H3396_Human0.79733657
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79312494
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78552092
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78003476
132* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77907942
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.77660049
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.77206043
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77113214
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76195776
137ELK1_19687146_ChIP-ChIP_HELA_Human0.75991840
138FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74955335
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74471812
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74383475
141FOXP3_21729870_ChIP-Seq_TREG_Human0.74336158
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.73893616
143BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.73654243
144SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.73504063
145KLF4_18555785_Chip-Seq_ESCs_Mouse0.73166408
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.73112306
147THAP11_20581084_ChIP-Seq_MESCs_Mouse0.72924849
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71633291
149HOXB4_20404135_ChIP-ChIP_EML_Mouse0.70689505
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70400408
151ERG_20517297_ChIP-Seq_VCAP_Human0.70397032
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.70293970
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69548731
154PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.66733377
155ERA_21632823_ChIP-Seq_H3396_Human0.65784432
156FOXH1_21741376_ChIP-Seq_EPCs_Human0.65367626
157CIITA_25753668_ChIP-Seq_RAJI_Human0.61952085
158SOX2_19829295_ChIP-Seq_ESCs_Human0.61535017
159NANOG_19829295_ChIP-Seq_ESCs_Human0.61535017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.87639276
2MP0002102_abnormal_ear_morphology5.31743049
3MP0005423_abnormal_somatic_nervous4.84203401
4MP0003136_yellow_coat_color4.42674153
5MP0003718_maternal_effect4.21710655
6MP0003111_abnormal_nucleus_morphology4.05189316
7MP0005451_abnormal_body_composition3.97803450
8MP0010094_abnormal_chromosome_stability3.41926791
9MP0004957_abnormal_blastocyst_morpholog3.36171709
10MP0006292_abnormal_olfactory_placode3.34263894
11MP0003077_abnormal_cell_cycle3.33186458
12MP0003123_paternal_imprinting3.01230554
13MP0009379_abnormal_foot_pigmentation2.92148831
14MP0008007_abnormal_cellular_replicative2.88786737
15MP0008058_abnormal_DNA_repair2.86443583
16MP0003646_muscle_fatigue2.82088039
17MP0008877_abnormal_DNA_methylation2.77416825
18MP0000372_irregular_coat_pigmentation2.66984832
19MP0008057_abnormal_DNA_replication2.65555974
20MP0009780_abnormal_chondrocyte_physiolo2.60133135
21MP0005360_urolithiasis2.58901681
22MP0006276_abnormal_autonomic_nervous2.53339579
23MP0005410_abnormal_fertilization2.48764351
24MP0002163_abnormal_gland_morphology2.46861708
25MP0010030_abnormal_orbit_morphology2.40962785
26MP0002127_abnormal_cardiovascular_syste2.34207902
27MP0002653_abnormal_ependyma_morphology2.28613584
28MP0005394_taste/olfaction_phenotype2.27833820
29MP0005499_abnormal_olfactory_system2.27833820
30MP0003315_abnormal_perineum_morphology2.20758480
31MP0002138_abnormal_hepatobiliary_system1.99548697
32MP0001730_embryonic_growth_arrest1.98797370
33MP0010307_abnormal_tumor_latency1.96978691
34MP0003879_abnormal_hair_cell1.93331895
35MP0005408_hypopigmentation1.93123131
36MP0005395_other_phenotype1.91420665
37MP0003787_abnormal_imprinting1.85004686
38MP0002210_abnormal_sex_determination1.84756931
39MP0008932_abnormal_embryonic_tissue1.84062971
40MP0001119_abnormal_female_reproductive1.77821577
41MP0001929_abnormal_gametogenesis1.77685075
42MP0000653_abnormal_sex_gland1.75974343
43MP0003937_abnormal_limbs/digits/tail_de1.75022714
44MP0000350_abnormal_cell_proliferation1.72817891
45MP0008789_abnormal_olfactory_epithelium1.72136791
46MP0004381_abnormal_hair_follicle1.66780111
47MP0001881_abnormal_mammary_gland1.65362150
48MP0003699_abnormal_female_reproductive1.63440605
49MP0001145_abnormal_male_reproductive1.60014623
50MP0002132_abnormal_respiratory_system1.58005900
51MP0003121_genomic_imprinting1.55879339
52MP0000462_abnormal_digestive_system1.50374994
53MP0002085_abnormal_embryonic_tissue1.48724660
54MP0005379_endocrine/exocrine_gland_phen1.46473252
55MP0005380_embryogenesis_phenotype1.46426370
56MP0001672_abnormal_embryogenesis/_devel1.46426370
57MP0002249_abnormal_larynx_morphology1.45229373
58MP0005647_abnormal_sex_gland1.45208110
59MP0009840_abnormal_foam_cell1.40700152
60MP0000579_abnormal_nail_morphology1.40321450
61MP0000566_synostosis1.39850225
62MP0002084_abnormal_developmental_patter1.35824031
63MP0003938_abnormal_ear_development1.35778665
64MP0003950_abnormal_plasma_membrane1.35711824
65MP0003786_premature_aging1.35115989
66MP0002396_abnormal_hematopoietic_system1.34840789
67MP0001502_abnormal_circadian_rhythm1.31688112
68MP0008260_abnormal_autophagy1.28474651
69MP0001697_abnormal_embryo_size1.26351110
70MP0002254_reproductive_system_inflammat1.25925707
71MP0000049_abnormal_middle_ear1.19372190
72MP0005310_abnormal_salivary_gland1.16874793
73MP0003984_embryonic_growth_retardation1.15983822
74MP0002088_abnormal_embryonic_growth/wei1.09068062
75MP0005187_abnormal_penis_morphology1.08385241
76MP0002161_abnormal_fertility/fecundity1.06344119
77MP0001968_abnormal_touch/_nociception1.06078219
78MP0003221_abnormal_cardiomyocyte_apopto1.03657137
79MP0003698_abnormal_male_reproductive1.02889936
80MP0001545_abnormal_hematopoietic_system1.02399760
81MP0005397_hematopoietic_system_phenotyp1.02399760
82MP0003195_calcinosis1.01569306
83MP0006036_abnormal_mitochondrial_physio1.00878323
84MP0002080_prenatal_lethality0.98170539
85MP0003755_abnormal_palate_morphology0.94307671
86MP0002086_abnormal_extraembryonic_tissu0.93727104
87MP0008995_early_reproductive_senescence0.88282100
88MP0002160_abnormal_reproductive_system0.87371889
89MP0001293_anophthalmia0.84870748
90MP0002277_abnormal_respiratory_mucosa0.81621308
91MP0004185_abnormal_adipocyte_glucose0.81476201
92MP0001529_abnormal_vocalization0.80875260
93MP0006035_abnormal_mitochondrial_morpho0.79536837
94MP0009672_abnormal_birth_weight0.78388490
95MP0000627_abnormal_mammary_gland0.78171315
96MP0004145_abnormal_muscle_electrophysio0.77493377
97MP0000631_abnormal_neuroendocrine_gland0.77131291
98MP0001661_extended_life_span0.76341113
99MP0009333_abnormal_splenocyte_physiolog0.75961370
100MP0002909_abnormal_adrenal_gland0.74523321
101MP0004885_abnormal_endolymph0.74445240
102MP0003936_abnormal_reproductive_system0.73830463
103MP0002233_abnormal_nose_morphology0.73472748
104MP0005621_abnormal_cell_physiology0.71455442
105MP0005551_abnormal_eye_electrophysiolog0.69181355
106MP0002019_abnormal_tumor_incidence0.69025044
107MP0004215_abnormal_myocardial_fiber0.68918913
108MP0000313_abnormal_cell_death0.68548744
109MP0003119_abnormal_digestive_system0.68439676
110MP0000639_abnormal_adrenal_gland0.68369142
111MP0001851_eye_inflammation0.68054909
112MP0001849_ear_inflammation0.67174269
113MP0000490_abnormal_crypts_of0.65593970
114MP0003866_abnormal_defecation0.65489708
115MP0000432_abnormal_head_morphology0.64884113
116MP0000358_abnormal_cell_content/0.64303564
117MP0002638_abnormal_pupillary_reflex0.63395386
118MP0000750_abnormal_muscle_regeneration0.61390180
119MP0010368_abnormal_lymphatic_system0.60905919
120MP0003567_abnormal_fetal_cardiomyocyte0.59705436
121MP0001346_abnormal_lacrimal_gland0.59579227
122MP0003861_abnormal_nervous_system0.58932254
123MP0001485_abnormal_pinna_reflex0.58864592
124MP0002332_abnormal_exercise_endurance0.58045130
125MP0005389_reproductive_system_phenotype0.57173979
126MP0003935_abnormal_craniofacial_develop0.57146740
127MP0005384_cellular_phenotype0.56380878
128MP0004270_analgesia0.56114737
129MP0002873_normal_phenotype0.55435771
130MP0002169_no_abnormal_phenotype0.55294318
131MP0002751_abnormal_autonomic_nervous0.54206032
132MP0002736_abnormal_nociception_after0.53127095
133MP0005266_abnormal_metabolism0.53085915
134MP0000647_abnormal_sebaceous_gland0.52680971
135MP0002177_abnormal_outer_ear0.51491244
136MP0000762_abnormal_tongue_morphology0.51091342
137MP0005646_abnormal_pituitary_gland0.51083752
138MP0005508_abnormal_skeleton_morphology0.50171593
139MP0010234_abnormal_vibrissa_follicle0.49284010
140MP0001919_abnormal_reproductive_system0.49156908
141MP0002234_abnormal_pharynx_morphology0.49135386
142MP0005197_abnormal_uvea_morphology0.48854885
143MP0010678_abnormal_skin_adnexa0.48745454
144MP0000383_abnormal_hair_follicle0.48429302
145MP0001727_abnormal_embryo_implantation0.47480133
146MP0001986_abnormal_taste_sensitivity0.46507278
147MP0002938_white_spotting0.46130839
148MP0005076_abnormal_cell_differentiation0.45722119
149MP0002877_abnormal_melanocyte_morpholog0.44637751
150MP0001286_abnormal_eye_development0.43476183

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.10661578
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.50651411
3Abnormality of the labia minora (HP:0012880)5.41301067
4Breast hypoplasia (HP:0003187)5.37049243
5Facial hemangioma (HP:0000329)5.07280056
6Prostate neoplasm (HP:0100787)5.06099393
7Chromsome breakage (HP:0040012)5.03660237
8Malnutrition (HP:0004395)4.77983973
9Patellar aplasia (HP:0006443)4.55567130
10Concave nail (HP:0001598)4.30833412
11Aplasia/Hypoplasia of the patella (HP:0006498)4.24389913
12Capillary hemangiomas (HP:0005306)4.08431835
13Papillary thyroid carcinoma (HP:0002895)4.08042038
14Hypercortisolism (HP:0001578)4.05442524
15Meckel diverticulum (HP:0002245)4.05420126
16Shawl scrotum (HP:0000049)4.02478027
17Abnormality of the preputium (HP:0100587)3.99954845
18Aplasia/hypoplasia of the uterus (HP:0008684)3.99378526
19Oligodactyly (hands) (HP:0001180)3.84720052
20Periauricular skin pits (HP:0100277)3.77782022
21Preauricular pit (HP:0004467)3.77782022
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.75844044
23Abnormality of the ileum (HP:0001549)3.75791691
24Patent foramen ovale (HP:0001655)3.70347445
25Abnormality of chromosome stability (HP:0003220)3.70310276
26Carpal bone hypoplasia (HP:0001498)3.66940065
27Dysphonia (HP:0001618)3.65037981
28Breast aplasia (HP:0100783)3.60312847
29Aplasia/Hypoplasia of the breasts (HP:0010311)3.44571342
30Oligodactyly (HP:0012165)3.43734051
31Atrioventricular block (HP:0001678)3.43415124
32Double outlet right ventricle (HP:0001719)3.32526657
33Congenital malformation of the right heart (HP:0011723)3.32526657
34Anhidrosis (HP:0000970)3.31329591
35Abnormal pancreas size (HP:0012094)3.27135002
36Male infertility (HP:0003251)3.25647010
37Absent radius (HP:0003974)3.24070337
38Abnormal rod and cone electroretinograms (HP:0008323)3.21971543
39Severe visual impairment (HP:0001141)3.21543658
40Hypoplasia of the uterus (HP:0000013)3.19793250
41Attenuation of retinal blood vessels (HP:0007843)3.13890646
42Infertility (HP:0000789)3.13311401
43Absent forearm bone (HP:0003953)3.11245426
44Aplasia involving forearm bones (HP:0009822)3.11245426
45Abnormality of the fovea (HP:0000493)3.08567577
46Azoospermia (HP:0000027)3.04627213
47Abnormality of lateral ventricle (HP:0030047)3.01898777
48Abnormality of the aortic arch (HP:0012303)3.01470436
49Impulsivity (HP:0100710)2.95355450
50Abnormal spermatogenesis (HP:0008669)2.93526000
51Hypophosphatemic rickets (HP:0004912)2.93202682
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92508384
53Rhinitis (HP:0012384)2.88513467
54Abnormality of the prostate (HP:0008775)2.86919337
55Secondary amenorrhea (HP:0000869)2.86510109
56Acute myeloid leukemia (HP:0004808)2.85316400
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.82329626
58Abnormal umbilical cord blood vessels (HP:0011403)2.81535894
59Single umbilical artery (HP:0001195)2.81535894
60Abnormality of the fetal cardiovascular system (HP:0010948)2.81535894
61Constricted visual fields (HP:0001133)2.79302237
62Microglossia (HP:0000171)2.77730136
63Clubbing of toes (HP:0100760)2.76424610
64Muscle stiffness (HP:0003552)2.75683849
65Small intestinal stenosis (HP:0012848)2.74212346
66Duodenal stenosis (HP:0100867)2.74212346
67Premature skin wrinkling (HP:0100678)2.72797794
68Adrenal hypoplasia (HP:0000835)2.70977242
69Glossoptosis (HP:0000162)2.68553126
70Microvesicular hepatic steatosis (HP:0001414)2.59648819
71Conical tooth (HP:0000698)2.59433975
72Congenital ichthyosiform erythroderma (HP:0007431)2.59072205
73Oligodontia (HP:0000677)2.59030628
74Flat capital femoral epiphysis (HP:0003370)2.56369880
75Aplasia/hypoplasia of the humerus (HP:0006507)2.54053466
76Cerebral hypomyelination (HP:0006808)2.53322772
77Aplasia/Hypoplasia of the macula (HP:0008059)2.52461117
78Supernumerary spleens (HP:0009799)2.50803311
79Skin pits (HP:0100276)2.50445878
80Wrist flexion contracture (HP:0001239)2.50035588
81Myelodysplasia (HP:0002863)2.48842267
82Short thumb (HP:0009778)2.47323608
83Short chin (HP:0000331)2.46107591
84Fused cervical vertebrae (HP:0002949)2.45650286
85Type 2 muscle fiber atrophy (HP:0003554)2.44678518
86Myokymia (HP:0002411)2.43901195
87Shoulder girdle muscle weakness (HP:0003547)2.43038353
88Acute lymphatic leukemia (HP:0006721)2.42885617
89Ectopic kidney (HP:0000086)2.42440830
90Short tibia (HP:0005736)2.41385386
91Bone marrow hypocellularity (HP:0005528)2.40210456
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.40027721
93Steatorrhea (HP:0002570)2.38265070
94Absent eyebrow (HP:0002223)2.36992417
95Adrenal overactivity (HP:0002717)2.35697090
96Horseshoe kidney (HP:0000085)2.35362570
97Spontaneous abortion (HP:0005268)2.34933326
98Abnormality of the carotid arteries (HP:0005344)2.33792429
99CNS hypomyelination (HP:0003429)2.31188999
100Aplasia/Hypoplasia involving the musculature (HP:0001460)2.30990704
101Aplasia/Hypoplasia affecting the retina (HP:0008061)2.30860498
102Bony spicule pigmentary retinopathy (HP:0007737)2.30545151
103Sparse eyelashes (HP:0000653)2.29431424
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29228515
105Heart block (HP:0012722)2.29176480
106Sensory axonal neuropathy (HP:0003390)2.27280890
107Absent septum pellucidum (HP:0001331)2.26414744
108Muscle fiber atrophy (HP:0100295)2.26229580
109Aplasia/Hypoplasia of the scapulae (HP:0006713)2.24548667
110Hypoplastic scapulae (HP:0000882)2.24548667
111Ankle contracture (HP:0006466)2.22592495
112Aplasia/Hypoplasia of the earlobes (HP:0009906)2.20655820
113Thyroid carcinoma (HP:0002890)2.18577369
114Overlapping toe (HP:0001845)2.17763421
115Abnormality of the duodenum (HP:0002246)2.16888717
116Reticulocytopenia (HP:0001896)2.16493080
117Abnormality of male internal genitalia (HP:0000022)2.16447053
118Microretrognathia (HP:0000308)2.15981040
119Anterior segment dysgenesis (HP:0007700)2.15070707
120Pendular nystagmus (HP:0012043)2.14543711
121Multiple enchondromatosis (HP:0005701)2.13615562
122Decreased central vision (HP:0007663)2.13495710
123Fat malabsorption (HP:0002630)2.13239149
124Abnormal atrioventricular conduction (HP:0005150)2.11113575
125Progressive muscle weakness (HP:0003323)2.07879420
126Limb dystonia (HP:0002451)2.06358847
127Stenosis of the external auditory canal (HP:0000402)2.04593853
128Pelvic girdle muscle weakness (HP:0003749)2.03647067
129Triphalangeal thumb (HP:0001199)2.03163771
130Hyperglycemia (HP:0003074)2.00727672
131Cystic hygroma (HP:0000476)1.99763413
132Pancreatic fibrosis (HP:0100732)1.99085358
133Insulin-resistant diabetes mellitus (HP:0000831)1.98236107
134Abnormality of the clitoris (HP:0000056)1.95583026
135Bicornuate uterus (HP:0000813)1.94945153
136Abnormality of chromosome segregation (HP:0002916)1.94875014
137Tracheoesophageal fistula (HP:0002575)1.94846037
138Cerebellar dysplasia (HP:0007033)1.94839687
139Oral leukoplakia (HP:0002745)1.94741148
140Rough bone trabeculation (HP:0100670)1.94406716
141Irregular epiphyses (HP:0010582)1.93786404
142Hypotrichosis (HP:0001006)1.93300950
143Midline defect of the nose (HP:0004122)1.91442991
144Cleft eyelid (HP:0000625)1.91393740
145Delayed puberty (HP:0000823)1.90865022
146Facial cleft (HP:0002006)1.90396232
147Abnormality of the fingertips (HP:0001211)1.89638894
148Cafe-au-lait spot (HP:0000957)1.87504635
149Lip pit (HP:0100267)1.86837034
150Premature ovarian failure (HP:0008209)1.86338428
151Sparse lateral eyebrow (HP:0005338)1.84241416
152Sloping forehead (HP:0000340)1.84143921
153Enlarged penis (HP:0000040)1.83096868
154Decreased muscle mass (HP:0003199)1.81871306
155Sensorimotor neuropathy (HP:0007141)1.80783206
156Abnormality of abdominal situs (HP:0011620)1.80720806
157Abdominal situs inversus (HP:0003363)1.80720806
158Type I diabetes mellitus (HP:0100651)1.79505866
159Hypergonadotropic hypogonadism (HP:0000815)1.79314110
160Septo-optic dysplasia (HP:0100842)1.78928157
161Arteriovenous malformation (HP:0100026)1.78891739
162Posterior subcapsular cataract (HP:0007787)1.78819415
163Aplasia/Hypoplasia of the fovea (HP:0008060)1.78512512
164Hypoplasia of the fovea (HP:0007750)1.78512512
165Sandal gap (HP:0001852)1.76917259
166Squamous cell carcinoma (HP:0002860)1.76817483
167Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.76597682
168Testicular atrophy (HP:0000029)1.75832131
169Horizontal nystagmus (HP:0000666)1.75646115
170Nephroblastoma (Wilms tumor) (HP:0002667)1.75614503
171Central scotoma (HP:0000603)1.75566647
172Aplasia/Hypoplasia of the sternum (HP:0006714)1.74493153
173Abnormality of the septum pellucidum (HP:0007375)1.73782992
174Abnormality of the labia (HP:0000058)1.72300964
175Aplasia/Hypoplasia of the ulna (HP:0006495)1.71999361
176Microtia (HP:0008551)1.71573950
177Ureteral duplication (HP:0000073)1.71316230
178Pulmonary fibrosis (HP:0002206)1.70974873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.84745039
2MUSK4.53165559
3LATS24.51582104
4WEE13.58976826
5STK38L3.51119589
6LATS13.36420575
7STK163.11567892
8PLK43.00918403
9CDK192.81502792
10CDC72.67581911
11KSR22.50184963
12EEF2K2.45681109
13ERBB42.41690092
14BRSK22.40402229
15TRIM282.37645738
16SRPK12.25264488
17TTK2.24915133
18RAF12.18401395
19BUB12.16696611
20BRAF1.99405534
21NEK21.95752861
22PLK11.94616352
23PLK31.87492564
24STK31.86821848
25MAP3K61.77276088
26BRSK11.71973832
27EIF2AK11.69155395
28MAP3K91.67559252
29ARAF1.56713040
30PAK61.53582738
31TAOK11.50365442
32INSRR1.42142912
33MAPKAPK31.41225139
34MKNK21.40408987
35KSR11.39043856
36AKT31.35381836
37CHEK21.29663094
38AURKB1.29206936
39WNK31.25744443
40PBK1.22675952
41LRRK21.20675082
42ADRBK21.18991876
43EIF2AK31.17664068
44VRK11.17057332
45DYRK31.16555500
46PNCK1.14014075
47CDK31.10873491
48ZAK1.07640303
49STK381.04862258
50DYRK21.04862120
51STK241.04365060
52GSK3A1.03765595
53MELK0.97157826
54TLK10.95447519
55CSNK2A10.94921832
56MAPK130.93414797
57PINK10.92693207
58CHEK10.92500138
59ACVR1B0.92456698
60RPS6KA40.92273422
61AURKA0.91674614
62CDK120.90949934
63CDK90.89257105
64STK100.88293851
65ABL20.86614318
66MAP3K50.86586750
67MAP3K130.86578237
68CSNK2A20.85441530
69NTRK30.85294290
70PIM20.84256972
71MAP3K100.83806342
72TSSK60.81456883
73RPS6KB20.80932737
74MKNK10.78534361
75STK390.78296556
76PRKAA20.77146118
77NUAK10.76675697
78PKN10.76395190
79PAK20.75981277
80BMX0.75339478
81WNK10.74529643
82MAPKAPK50.73703108
83OXSR10.70745272
84PRKAA10.68988776
85TAOK30.68503928
86NEK10.68453315
87NEK60.67521610
88AKT20.67505970
89TRPM70.66268463
90CDK70.66103346
91ATM0.65773257
92CDK20.62530605
93EIF2AK20.62175196
94PLK20.62168655
95PRKCI0.62158040
96PRKD30.58949815
97KIT0.58733061
98MST40.57472758
99WNK40.56463221
100MAP3K80.55358702
101MAPK110.55119685
102NME10.54190214
103MTOR0.51167216
104CDK10.50782949
105KDR0.47225476
106PAK10.46330659
107IRAK30.45257948
108TNIK0.44447365
109ALK0.44211286
110MAPK100.43507009
111MARK20.42906932
112FRK0.42362300
113MAPK10.42017646
114ATR0.41953601
115CLK10.41949483
116CCNB10.40967528
117PIM10.36784830
118ADRBK10.36772243
119PRKCE0.36219701
120PRKG10.36064370
121PDK40.35834714
122PDK30.35834714
123MARK30.35387233
124CSNK1A10.35258094
125STK40.34542794
126PRKD10.34366435
127CDK11A0.34112287
128MAPK140.33799087
129CDK40.33117399
130RPS6KA10.32442230
131PRKCG0.32313993
132NTRK20.31957242
133EPHA30.31752439
134PRKACB0.28276175
135EPHA20.27267126
136CSNK1E0.26958651
137PAK30.26711767
138CSNK1G10.25809249
139AKT10.24514059
140ABL10.24243064
141PRKD20.23830795
142BMPR1B0.22793167
143MOS0.22706361
144PDK20.22385621
145CSNK1G20.21917292
146CDK80.20567929
147PRKACA0.20415576
148CSNK1G30.20354073
149SGK20.20216371
150GSK3B0.20009569
151CDK50.19287793

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.36666247
2RNA polymerase_Homo sapiens_hsa030204.91765264
3Cell cycle_Homo sapiens_hsa041104.18452126
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23650101
5Ribosome_Homo sapiens_hsa030103.20684220
6Basal transcription factors_Homo sapiens_hsa030223.19571572
7Homologous recombination_Homo sapiens_hsa034403.06964042
8RNA transport_Homo sapiens_hsa030133.03499693
9Fanconi anemia pathway_Homo sapiens_hsa034602.76913943
10RNA degradation_Homo sapiens_hsa030182.75390304
11Pentose phosphate pathway_Homo sapiens_hsa000302.72655123
12Taste transduction_Homo sapiens_hsa047422.36597540
13p53 signaling pathway_Homo sapiens_hsa041152.30022961
14Pyrimidine metabolism_Homo sapiens_hsa002401.94885197
15Mismatch repair_Homo sapiens_hsa034301.92920177
16DNA replication_Homo sapiens_hsa030301.90476858
17Nucleotide excision repair_Homo sapiens_hsa034201.88294290
18Oocyte meiosis_Homo sapiens_hsa041141.85729083
19Linoleic acid metabolism_Homo sapiens_hsa005911.84213387
20mRNA surveillance pathway_Homo sapiens_hsa030151.82265767
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79450122
22Spliceosome_Homo sapiens_hsa030401.75007130
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70932735
24Circadian rhythm_Homo sapiens_hsa047101.60089817
25Purine metabolism_Homo sapiens_hsa002301.56352695
26Ovarian steroidogenesis_Homo sapiens_hsa049131.50080564
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45227870
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42206315
29Ether lipid metabolism_Homo sapiens_hsa005651.37531400
30TGF-beta signaling pathway_Homo sapiens_hsa043501.34023346
31Caffeine metabolism_Homo sapiens_hsa002321.32216455
32Biosynthesis of amino acids_Homo sapiens_hsa012301.30853434
33Olfactory transduction_Homo sapiens_hsa047401.29133147
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.22467383
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19833372
36Base excision repair_Homo sapiens_hsa034101.17583452
37Fatty acid biosynthesis_Homo sapiens_hsa000611.10636584
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09697236
39Cardiac muscle contraction_Homo sapiens_hsa042601.08830628
40Regulation of autophagy_Homo sapiens_hsa041401.05475748
41Epstein-Barr virus infection_Homo sapiens_hsa051690.98741484
42Huntingtons disease_Homo sapiens_hsa050160.98657581
43Sphingolipid metabolism_Homo sapiens_hsa006000.96371429
44Steroid biosynthesis_Homo sapiens_hsa001000.95204055
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.91977100
46MicroRNAs in cancer_Homo sapiens_hsa052060.90647335
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90120132
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86566151
49Arachidonic acid metabolism_Homo sapiens_hsa005900.81835674
50Pancreatic cancer_Homo sapiens_hsa052120.80599093
51Nicotine addiction_Homo sapiens_hsa050330.80202183
52Renal cell carcinoma_Homo sapiens_hsa052110.77577098
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73457800
54Proteasome_Homo sapiens_hsa030500.71083510
55Arginine and proline metabolism_Homo sapiens_hsa003300.69344789
56Choline metabolism in cancer_Homo sapiens_hsa052310.68940042
57Vitamin digestion and absorption_Homo sapiens_hsa049770.67046945
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65182382
59Small cell lung cancer_Homo sapiens_hsa052220.63438123
60Wnt signaling pathway_Homo sapiens_hsa043100.62848602
61Prolactin signaling pathway_Homo sapiens_hsa049170.62163119
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61522134
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.61446777
64Insulin secretion_Homo sapiens_hsa049110.59097450
65Sulfur metabolism_Homo sapiens_hsa009200.58496531
66Non-homologous end-joining_Homo sapiens_hsa034500.57226832
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56493369
68FoxO signaling pathway_Homo sapiens_hsa040680.56214296
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54297446
70Tryptophan metabolism_Homo sapiens_hsa003800.52776535
71GnRH signaling pathway_Homo sapiens_hsa049120.52434378
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52296578
73Parkinsons disease_Homo sapiens_hsa050120.52161220
74One carbon pool by folate_Homo sapiens_hsa006700.51309423
75Viral carcinogenesis_Homo sapiens_hsa052030.51174595
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.48957708
77ABC transporters_Homo sapiens_hsa020100.48263497
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47955563
79Colorectal cancer_Homo sapiens_hsa052100.47154076
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47090068
81Prostate cancer_Homo sapiens_hsa052150.46964665
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.46242025
83Hippo signaling pathway_Homo sapiens_hsa043900.45056123
84Morphine addiction_Homo sapiens_hsa050320.44745664
85Thyroid cancer_Homo sapiens_hsa052160.43028672
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43001715
87Fatty acid elongation_Homo sapiens_hsa000620.42377434
88Herpes simplex infection_Homo sapiens_hsa051680.42282738
89Dorso-ventral axis formation_Homo sapiens_hsa043200.41115664
90Salivary secretion_Homo sapiens_hsa049700.41053818
91Serotonergic synapse_Homo sapiens_hsa047260.40849804
92GABAergic synapse_Homo sapiens_hsa047270.40773591
93Calcium signaling pathway_Homo sapiens_hsa040200.40629892
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39958102
95Folate biosynthesis_Homo sapiens_hsa007900.39803601
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37885783
97Other glycan degradation_Homo sapiens_hsa005110.37598539
98Mineral absorption_Homo sapiens_hsa049780.36675975
99Alcoholism_Homo sapiens_hsa050340.35813833
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35353648
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34976405
102Protein digestion and absorption_Homo sapiens_hsa049740.34881846
103Arginine biosynthesis_Homo sapiens_hsa002200.34286414
104Legionellosis_Homo sapiens_hsa051340.31441328
105Estrogen signaling pathway_Homo sapiens_hsa049150.31351150
106Inositol phosphate metabolism_Homo sapiens_hsa005620.30952260
107Hepatitis B_Homo sapiens_hsa051610.30715959
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30578568
109Systemic lupus erythematosus_Homo sapiens_hsa053220.30571894
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29409912
111Circadian entrainment_Homo sapiens_hsa047130.27322447
112Adherens junction_Homo sapiens_hsa045200.26762025
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.25629008
114Glutathione metabolism_Homo sapiens_hsa004800.24868263
115Carbon metabolism_Homo sapiens_hsa012000.24815407
116beta-Alanine metabolism_Homo sapiens_hsa004100.23893400
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22763949
118Glycerolipid metabolism_Homo sapiens_hsa005610.22118996
119Phototransduction_Homo sapiens_hsa047440.21961176
120Endometrial cancer_Homo sapiens_hsa052130.21947635
121Bile secretion_Homo sapiens_hsa049760.19335610
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19263781
123Lysine degradation_Homo sapiens_hsa003100.18918453
124Pathways in cancer_Homo sapiens_hsa052000.18846565
125Cocaine addiction_Homo sapiens_hsa050300.17663803
126Amphetamine addiction_Homo sapiens_hsa050310.17088995
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.16288739
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14818210
129mTOR signaling pathway_Homo sapiens_hsa041500.14681177
130cAMP signaling pathway_Homo sapiens_hsa040240.14657998
131Chemical carcinogenesis_Homo sapiens_hsa052040.14526849
132Retinol metabolism_Homo sapiens_hsa008300.14272201
133Metabolic pathways_Homo sapiens_hsa011000.13946677
134Selenocompound metabolism_Homo sapiens_hsa004500.13465943
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.12990741
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.12507365
137Hedgehog signaling pathway_Homo sapiens_hsa043400.12074902
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11876579
139VEGF signaling pathway_Homo sapiens_hsa043700.11737829
140HTLV-I infection_Homo sapiens_hsa051660.11626962
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11494267
142Tight junction_Homo sapiens_hsa045300.09700952
143Long-term depression_Homo sapiens_hsa047300.09589992
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09127238
145AMPK signaling pathway_Homo sapiens_hsa041520.08913217
146Ras signaling pathway_Homo sapiens_hsa040140.07913869
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07271557
148Butanoate metabolism_Homo sapiens_hsa006500.06027609

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