PRAMEF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.38537597
2meiosis I (GO:0007127)5.48111185
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)43.8663794
4regulation of acrosome reaction (GO:0060046)4.49497658
5regulation of DNA methylation (GO:0044030)4.41044970
6regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.34091948
7regulation of retinoic acid receptor signaling pathway (GO:0048385)36.6998330
8positive regulation of uterine smooth muscle contraction (GO:0070474)3.94517440
9regulation of female gonad development (GO:2000194)3.74107019
10mitotic chromosome condensation (GO:0007076)3.72685960
11multicellular organism reproduction (GO:0032504)3.53353511
12male meiosis (GO:0007140)3.47961988
13regulation of female receptivity (GO:0045924)3.45212467
14aggressive behavior (GO:0002118)3.45094068
15drinking behavior (GO:0042756)3.28526853
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16771139
17regulation of penile erection (GO:0060405)3.12500688
18regulation of cytokine production involved in inflammatory response (GO:1900015)3.10590263
19transcription from mitochondrial promoter (GO:0006390)3.03150864
20regulation of uterine smooth muscle contraction (GO:0070472)3.03072418
21hyperosmotic salinity response (GO:0042538)3.02124733
22regulation of histone H3-K9 methylation (GO:0051570)3.02046864
23female mating behavior (GO:0060180)2.96785250
24mitotic metaphase plate congression (GO:0007080)2.94354093
25positive regulation of prostaglandin secretion (GO:0032308)2.92485714
26response to acidic pH (GO:0010447)2.87380156
27oocyte development (GO:0048599)2.86844443
28protein kinase C signaling (GO:0070528)2.85695587
29regulation of mitotic spindle organization (GO:0060236)2.81800481
30regulation of spindle organization (GO:0090224)2.77265808
31positive regulation of humoral immune response (GO:0002922)2.76248576
32ribosome assembly (GO:0042255)2.75840929
33negative regulation of reproductive process (GO:2000242)2.75309112
34positive regulation of digestive system process (GO:0060456)2.74527535
35sleep (GO:0030431)2.74022531
36positive regulation of catecholamine secretion (GO:0033605)2.72680529
37negative regulation of digestive system process (GO:0060457)2.71722838
38maturation of SSU-rRNA (GO:0030490)2.63697489
39protein localization to chromosome, centromeric region (GO:0071459)2.60959146
40cellular response to pH (GO:0071467)2.59914465
41meiotic nuclear division (GO:0007126)2.52629268
42meiotic cell cycle (GO:0051321)2.52012044
43regulation of prostaglandin secretion (GO:0032306)2.47573477
44snRNA transcription (GO:0009301)2.47496228
45autophagic vacuole assembly (GO:0000045)2.46493332
46attachment of spindle microtubules to kinetochore (GO:0008608)2.45488151
47rRNA modification (GO:0000154)2.43818396
48positive regulation of histone H3-K4 methylation (GO:0051571)2.42751250
49chromosome condensation (GO:0030261)2.42548200
50telomere maintenance via telomere lengthening (GO:0010833)2.40032057
51glycine transport (GO:0015816)2.37165290
52ventricular cardiac muscle cell development (GO:0055015)2.35578479
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.33858350
54regulation of RNA export from nucleus (GO:0046831)2.31994499
55metaphase plate congression (GO:0051310)2.31969790
56reproduction (GO:0000003)2.31901748
57chaperone-mediated protein transport (GO:0072321)2.31213402
58negative regulation of histone methylation (GO:0031061)2.29967064
59positive regulation of protein homooligomerization (GO:0032464)2.29760934
60polyamine biosynthetic process (GO:0006596)2.28132721
61regulation of exit from mitosis (GO:0007096)2.26208960
62oocyte maturation (GO:0001556)2.24553614
63regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.23189532
64regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.22501974
65meiotic cell cycle process (GO:1903046)2.18207960
66muscle organ morphogenesis (GO:0048644)2.16305017
67nuclear pore complex assembly (GO:0051292)2.14651962
68nuclear pore organization (GO:0006999)2.12668133
69maternal behavior (GO:0042711)2.12647955
70regulation of G0 to G1 transition (GO:0070316)2.12298468
71positive regulation of cytokinesis (GO:0032467)2.10420957
72histone H3-K9 demethylation (GO:0033169)2.10195953
73primitive streak formation (GO:0090009)2.09343452
74chaperone mediated protein folding requiring cofactor (GO:0051085)2.08813494
75N-terminal protein amino acid acetylation (GO:0006474)2.08218159
76retinal cone cell development (GO:0046549)2.07210862
77regulation of norepinephrine secretion (GO:0014061)2.05356744
78positive regulation of reproductive process (GO:2000243)2.05304536
79regulation of cell cycle G2/M phase transition (GO:1902749)2.05120479
80response to food (GO:0032094)2.03307868
81kinetochore assembly (GO:0051382)2.02522021
82DNA replication initiation (GO:0006270)2.01366123
83rRNA methylation (GO:0031167)2.00079071
84termination of RNA polymerase III transcription (GO:0006386)2.00065482
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.00065482
86binding of sperm to zona pellucida (GO:0007339)1.99825876
87positive regulation of chromosome segregation (GO:0051984)1.98633057
88DNA packaging (GO:0006323)1.96917555
89protein K6-linked ubiquitination (GO:0085020)1.96296283
90regulation of helicase activity (GO:0051095)1.91778673
91negative regulation of phosphoprotein phosphatase activity (GO:0032515)1.91412887
92regulation of meiosis I (GO:0060631)1.90428526
93androgen receptor signaling pathway (GO:0030521)1.87626887
94regulation of histone methylation (GO:0031060)1.87239839
95parental behavior (GO:0060746)1.86341348
96regulation of nucleobase-containing compound transport (GO:0032239)1.85489570
97piRNA metabolic process (GO:0034587)1.83851692
98negative regulation of meiosis (GO:0045835)1.82750721
99L-amino acid import (GO:0043092)1.82159716
100skeletal muscle tissue regeneration (GO:0043403)1.81355386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.29178519
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.70457213
3EZH2_22144423_ChIP-Seq_EOC_Human5.60499925
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.46474101
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.46474101
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.46474101
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.09646155
8NOTCH1_21737748_ChIP-Seq_TLL_Human4.76142864
9E2F7_22180533_ChIP-Seq_HELA_Human3.94162644
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.55394414
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.36538785
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35626701
13TP63_19390658_ChIP-ChIP_HaCaT_Human3.26428560
14ZNF274_21170338_ChIP-Seq_K562_Hela2.90353398
15ETV1_20927104_ChIP-Seq_GIST48_Human2.86875374
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84027125
17RBPJ_21746931_ChIP-Seq_IB4_Human2.65422299
18TBL1_22424771_ChIP-Seq_293T_Human2.42081501
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40462336
20NFYB_21822215_ChIP-Seq_K562_Human2.32916013
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29759179
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27054828
23PHF8_20622853_ChIP-Seq_HELA_Human2.24684252
24GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.13766099
25AR_21909140_ChIP-Seq_LNCAP_Human2.09015900
26GATA6_21074721_ChIP-Seq_CACO-2_Human2.06280487
27CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.99061633
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.95934876
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95120598
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.91977119
31HNFA_21074721_ChIP-Seq_CACO-2_Human1.78884953
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75341605
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.74875876
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62242961
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53043954
36NFYA_21822215_ChIP-Seq_K562_Human1.50232486
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.48885517
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45706264
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43526077
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37563923
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33667376
42PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30374602
43VDR_23849224_ChIP-Seq_CD4+_Human1.25927934
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24551892
45TTF2_22483619_ChIP-Seq_HELA_Human1.20224758
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16537704
47NANOG_20526341_ChIP-Seq_ESCs_Human1.16197790
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.16008127
49RAC3_21632823_ChIP-Seq_H3396_Human1.15975748
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15174675
51* MYC_18940864_ChIP-ChIP_HL60_Human1.10738164
52XRN2_22483619_ChIP-Seq_HELA_Human1.05282516
53STAT1_20625510_ChIP-Seq_HELA_Human1.04741731
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98255610
55MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98244294
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97082735
57YY1_21170310_ChIP-Seq_MESCs_Mouse0.96278785
58MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93263694
59CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92786952
60ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92391747
61THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90290110
62ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89076713
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88567354
64SOX2_21211035_ChIP-Seq_LN229_Human0.87897963
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87469182
66ELK1_22589737_ChIP-Seq_MCF10A_Human0.87432019
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85542483
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85440135
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82972243
70GABP_19822575_ChIP-Seq_HepG2_Human0.81403930
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79879617
72FOXP3_21729870_ChIP-Seq_TREG_Human0.79204553
73ELK1_19687146_ChIP-ChIP_HELA_Human0.78827554
74TP53_22573176_ChIP-Seq_HFKS_Human0.78811824
75E2F1_20622854_ChIP-Seq_HELA_Human0.77797839
76CTCF_20526341_ChIP-Seq_ESCs_Human0.76609961
77LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76527874
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75291512
79ZNF263_19887448_ChIP-Seq_K562_Human0.73580166
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73297648
81IRF1_19129219_ChIP-ChIP_H3396_Human0.72250341
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.72118143
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72023175
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71785526
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.69820219
86E2F1_21310950_ChIP-Seq_MCF-7_Human0.69704661
87RNF2_27304074_Chip-Seq_NSC_Mouse0.69699635
88CIITA_25753668_ChIP-Seq_RAJI_Human0.69311605
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66632856
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66544357
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66187737
92EGR1_19374776_ChIP-ChIP_THP-1_Human0.66067795
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.64199968
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.63095529
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62943218
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.62908946
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.62821296
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.62774118
99KDM5A_27292631_Chip-Seq_BREAST_Human0.60821879
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.58898179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.23989292
2MP0003718_maternal_effect5.02885989
3MP0001986_abnormal_taste_sensitivity4.95886787
4MP0005423_abnormal_somatic_nervous4.58546899
5MP0005499_abnormal_olfactory_system3.68764082
6MP0005394_taste/olfaction_phenotype3.68764082
7MP0010307_abnormal_tumor_latency3.29357678
8MP0009379_abnormal_foot_pigmentation3.01587502
9MP0002127_abnormal_cardiovascular_syste2.78730921
10MP0010030_abnormal_orbit_morphology2.75045713
11MP0002277_abnormal_respiratory_mucosa2.71554839
12MP0003693_abnormal_embryo_hatching2.68661188
13MP0008057_abnormal_DNA_replication2.63451103
14MP0002160_abnormal_reproductive_system2.38636202
15MP0004957_abnormal_blastocyst_morpholog2.36858211
16MP0003111_abnormal_nucleus_morphology2.36837767
17MP0008789_abnormal_olfactory_epithelium2.31241048
18MP0003077_abnormal_cell_cycle2.26436746
19MP0001929_abnormal_gametogenesis2.25391497
20MP0005410_abnormal_fertilization2.25080574
21MP0008877_abnormal_DNA_methylation2.21913780
22MP0002210_abnormal_sex_determination2.17214741
23MP0010094_abnormal_chromosome_stability2.02780463
24MP0005395_other_phenotype2.02620594
25MP0002138_abnormal_hepatobiliary_system2.00277650
26MP0001881_abnormal_mammary_gland1.90819986
27MP0009333_abnormal_splenocyte_physiolog1.82351379
28MP0002254_reproductive_system_inflammat1.80764112
29MP0008058_abnormal_DNA_repair1.78749033
30MP0006276_abnormal_autonomic_nervous1.72539146
31MP0003121_genomic_imprinting1.71367616
32MP0003699_abnormal_female_reproductive1.67792813
33MP0005389_reproductive_system_phenotype1.63227167
34MP0005360_urolithiasis1.62586307
35MP0009840_abnormal_foam_cell1.54237266
36MP0002161_abnormal_fertility/fecundity1.48870668
37MP0003136_yellow_coat_color1.46939219
38MP0000653_abnormal_sex_gland1.45644448
39MP0002234_abnormal_pharynx_morphology1.45497215
40MP0005647_abnormal_sex_gland1.41933914
41MP0001293_anophthalmia1.41018715
42MP0008260_abnormal_autophagy1.36217970
43MP0003698_abnormal_male_reproductive1.35275305
44MP0001672_abnormal_embryogenesis/_devel1.31148042
45MP0005380_embryogenesis_phenotype1.31148042
46MP0008932_abnormal_embryonic_tissue1.29806500
47MP0001145_abnormal_male_reproductive1.24864282
48MP0005646_abnormal_pituitary_gland1.21953993
49MP0002233_abnormal_nose_morphology1.19098300
50MP0001502_abnormal_circadian_rhythm1.15901353
51MP0000350_abnormal_cell_proliferation1.15350894
52MP0010368_abnormal_lymphatic_system1.15160202
53MP0001730_embryonic_growth_arrest1.14182155
54MP0003195_calcinosis1.07177917
55MP0000372_irregular_coat_pigmentation1.07015485
56MP0001545_abnormal_hematopoietic_system1.06709577
57MP0005397_hematopoietic_system_phenotyp1.06709577
58MP0000049_abnormal_middle_ear1.06681179
59MP0003984_embryonic_growth_retardation1.04889901
60MP0000762_abnormal_tongue_morphology1.03434716
61MP0003646_muscle_fatigue1.00304324
62MP0002088_abnormal_embryonic_growth/wei0.98491412
63MP0000627_abnormal_mammary_gland0.96939069
64MP0003890_abnormal_embryonic-extraembry0.89311055
65MP0003938_abnormal_ear_development0.89101819
66MP0001119_abnormal_female_reproductive0.88508827
67MP0001697_abnormal_embryo_size0.82350948
68MP0006036_abnormal_mitochondrial_physio0.78672372
69MP0000428_abnormal_craniofacial_morphol0.76098811
70MP0003936_abnormal_reproductive_system0.75120532
71MP0003755_abnormal_palate_morphology0.75025456
72MP0003828_pulmonary_edema0.74892500
73MP0003950_abnormal_plasma_membrane0.74550674
74MP0008995_early_reproductive_senescence0.72433301
75MP0004381_abnormal_hair_follicle0.72374117
76MP0003879_abnormal_hair_cell0.72118578
77MP0005197_abnormal_uvea_morphology0.70093388
78MP0002751_abnormal_autonomic_nervous0.68754088
79MP0000631_abnormal_neuroendocrine_gland0.68025654
80MP0004215_abnormal_myocardial_fiber0.67028628
81MP0000358_abnormal_cell_content/0.66161224
82MP0002080_prenatal_lethality0.64930643
83MP0004142_abnormal_muscle_tone0.63029478
84MP0002139_abnormal_hepatobiliary_system0.62075817
85MP0002084_abnormal_developmental_patter0.61155392
86MP0002873_normal_phenotype0.60653526
87MP0002169_no_abnormal_phenotype0.60496141
88MP0001286_abnormal_eye_development0.60453771
89MP0001666_abnormal_nutrient_absorption0.60188776
90MP0002085_abnormal_embryonic_tissue0.60182084
91MP0003123_paternal_imprinting0.57259448
92MP0001919_abnormal_reproductive_system0.56374448
93MP0005451_abnormal_body_composition0.52003527
94MP0003119_abnormal_digestive_system0.49519795
95MP0002086_abnormal_extraembryonic_tissu0.47272626
96MP0003935_abnormal_craniofacial_develop0.43355742
97MP0000313_abnormal_cell_death0.41345964
98MP0001440_abnormal_grooming_behavior0.41222508
99MP0004019_abnormal_vitamin_homeostasis0.40718395
100MP0004808_abnormal_hematopoietic_stem0.39850746

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.16121340
2Malnutrition (HP:0004395)6.48977860
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.43289297
4Premature ovarian failure (HP:0008209)4.77731594
5Hypercortisolism (HP:0001578)4.33312510
6Carpal bone hypoplasia (HP:0001498)4.19232829
7Aplasia/hypoplasia of the uterus (HP:0008684)4.11453533
8Impulsivity (HP:0100710)4.09892453
9Abnormality of the septum pellucidum (HP:0007375)3.95401485
10Preauricular pit (HP:0004467)3.93140861
11Periauricular skin pits (HP:0100277)3.93140861
12Hypophosphatemic rickets (HP:0004912)3.60546328
13Septo-optic dysplasia (HP:0100842)3.57849765
14Patent foramen ovale (HP:0001655)3.57597300
15Rhinitis (HP:0012384)3.53077723
16Birth length less than 3rd percentile (HP:0003561)3.42403112
17Abdominal situs inversus (HP:0003363)3.39275208
18Abnormality of abdominal situs (HP:0011620)3.39275208
19Aplasia/Hypoplasia involving the musculature (HP:0001460)3.36113038
20Infertility (HP:0000789)3.35797101
21Muscle stiffness (HP:0003552)3.35589923
22Myokymia (HP:0002411)3.34575538
23Aplasia/hypoplasia of the humerus (HP:0006507)3.29391785
24Absent septum pellucidum (HP:0001331)3.20045172
25Steatorrhea (HP:0002570)3.18012798
26Hypoplasia of the uterus (HP:0000013)3.14178341
27Midline defect of the nose (HP:0004122)2.97285681
28Sensory axonal neuropathy (HP:0003390)2.92331716
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.90472535
30Short tibia (HP:0005736)2.90330455
31Fat malabsorption (HP:0002630)2.76709362
32Tetraparesis (HP:0002273)2.70951120
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70259607
34Meckel diverticulum (HP:0002245)2.69307772
35Abnormal pancreas size (HP:0012094)2.67239477
36Skin pits (HP:0100276)2.65161051
37Reticulocytopenia (HP:0001896)2.60333631
38Chromsome breakage (HP:0040012)2.60292184
39Ureteral duplication (HP:0000073)2.59947867
40Abnormality of the preputium (HP:0100587)2.59637370
41Progressive sensorineural hearing impairment (HP:0000408)2.59466721
42Abnormality of the ileum (HP:0001549)2.59163487
43Mitral stenosis (HP:0001718)2.57886674
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.56737443
45Apathy (HP:0000741)2.55863921
46Congenital malformation of the right heart (HP:0011723)2.54477943
47Double outlet right ventricle (HP:0001719)2.54477943
48Sparse lateral eyebrow (HP:0005338)2.52039613
49Adrenal overactivity (HP:0002717)2.50171786
50Hypergonadotropic hypogonadism (HP:0000815)2.49637073
51Hypoplastic scapulae (HP:0000882)2.48537537
52Aplasia/Hypoplasia of the scapulae (HP:0006713)2.48537537
53Facial cleft (HP:0002006)2.48378620
54Abnormality of the fetal cardiovascular system (HP:0010948)2.44189004
55Abnormal umbilical cord blood vessels (HP:0011403)2.44189004
56Single umbilical artery (HP:0001195)2.44189004
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.42475218
58Hypoplasia of the fovea (HP:0007750)2.42475218
59Dysphonia (HP:0001618)2.39687806
60Osteomalacia (HP:0002749)2.39394374
61Hypoglycemic seizures (HP:0002173)2.39093329
62Microretrognathia (HP:0000308)2.35384855
63Constricted visual fields (HP:0001133)2.33943692
64Cortical visual impairment (HP:0100704)2.33403299
65Fused cervical vertebrae (HP:0002949)2.30409533
66Progressive hearing impairment (HP:0001730)2.30230133
67Absent radius (HP:0003974)2.29790646
68Glossoptosis (HP:0000162)2.29636500
69Cleft eyelid (HP:0000625)2.26084001
70Selective tooth agenesis (HP:0001592)2.21820003
71Diminished motivation (HP:0000745)2.21751707
72Delayed CNS myelination (HP:0002188)2.16674090
73Absent forearm bone (HP:0003953)2.16442861
74Aplasia involving forearm bones (HP:0009822)2.16442861
75Testicular atrophy (HP:0000029)2.13449271
76Atresia of the external auditory canal (HP:0000413)2.13301756
77Attenuation of retinal blood vessels (HP:0007843)2.12682201
78Short humerus (HP:0005792)2.10358219
79Abnormal number of incisors (HP:0011064)2.07739095
80Horseshoe kidney (HP:0000085)2.07297258
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06139391
82Maternal diabetes (HP:0009800)2.05661745
83Progressive muscle weakness (HP:0003323)2.04531684
84Multiple enchondromatosis (HP:0005701)2.03963889
85Stenosis of the external auditory canal (HP:0000402)2.03928181
86Chronic sinusitis (HP:0011109)2.02118207
87Anterior segment dysgenesis (HP:0007700)2.00395853
88Congenital ichthyosiform erythroderma (HP:0007431)2.00060867
89Azoospermia (HP:0000027)1.99102364
90Abnormality of the pubic bones (HP:0003172)1.97843330
91Limb dystonia (HP:0002451)1.93238234
92Absent thumb (HP:0009777)1.92214057
93Nausea (HP:0002018)1.91611050
94Abnormal ciliary motility (HP:0012262)1.91596051
95Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90900965
96Concave nail (HP:0001598)1.86608444
97Increased circulating renin level (HP:0000848)1.85724345
98Fibular aplasia (HP:0002990)1.84886478
99Gonadotropin excess (HP:0000837)1.83242237
100Spinal cord lesions (HP:0100561)1.83189564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.44321438
2TESK25.41298998
3SRPK14.29938633
4BUB14.20689481
5TRIM283.30480248
6NEK63.15020969
7CDK92.77796866
8DYRK32.66778329
9CDK192.40638909
10STK162.34469592
11PLK12.34194361
12BRSK12.30185899
13BRSK22.12052611
14CDC72.04006374
15CDK121.95574322
16PIM21.95268846
17TAOK31.85711960
18AURKB1.83876020
19PLK31.75350939
20MARK31.74609221
21MAP3K91.59234664
22PBK1.57501076
23PRKCI1.53699576
24GSK3A1.52254007
25CDK71.52063335
26AURKA1.49866605
27WNK31.33898008
28NEK21.31756669
29CHEK11.30544608
30RAF11.29715434
31PDK21.22047143
32CSNK1E1.21895039
33PIM11.13115099
34MELK1.12763031
35TTK1.08286155
36WNK11.06304423
37LRRK21.03840513
38MAP3K51.02973553
39PKN10.97073399
40ZAK0.91526481
41BRD40.89918339
42PAK20.88649609
43CDK20.87183081
44PLK40.86397357
45NTRK30.85032974
46EIF2AK30.84576832
47STK30.83237845
48TLK10.83002462
49CSNK2A20.82291821
50CSNK2A10.76584560
51CHEK20.75619961
52MTOR0.75182225
53CDK10.74879888
54ATR0.73209133
55PAK10.72788404
56STK240.71363003
57STK40.70230312
58TNIK0.66297243
59WEE10.65120154
60NME10.52986469
61ATM0.52506850
62PRKG10.47337705
63TAOK20.46434612
64GSK3B0.46295322
65KDR0.44853298
66TBK10.43614605
67MAPK110.41742942
68MAPK10.40359607
69CSNK1D0.39583086
70DMPK0.39348939
71AKT20.38405847
72TESK10.37988510
73PRKACB0.37132320
74MAPK140.36314140
75CLK10.32857060
76PRKD10.32732330
77RPS6KA10.30724065
78VRK10.29368357
79STK100.28600049
80MAPK100.28053278
81CDK50.26987126
82MAP3K40.26667544
83ARAF0.26230871
84TIE10.25628426
85CDK11A0.25014117
86MAP3K80.24682063
87ABL20.22733187
88PRKAA10.22210299
89PRPF4B0.21640110
90CAMK10.20299231
91TSSK60.20049302
92LMTK20.19780340
93DYRK1A0.19778232
94PRKACA0.19756671
95CDK30.19473762
96MAPK40.18068245
97EIF2AK20.17652986
98PRKD20.17296965
99PLK20.16350750
100CSNK1A10.15982022

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030226.38679833
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.16357899
3mRNA surveillance pathway_Homo sapiens_hsa030153.89720153
4Regulation of autophagy_Homo sapiens_hsa041403.78288608
5Cell cycle_Homo sapiens_hsa041103.45898391
6RNA polymerase_Homo sapiens_hsa030203.43421346
7Ribosome_Homo sapiens_hsa030103.07512068
8RNA transport_Homo sapiens_hsa030132.99654141
9p53 signaling pathway_Homo sapiens_hsa041152.94627999
10Oocyte meiosis_Homo sapiens_hsa041142.67962981
11Spliceosome_Homo sapiens_hsa030402.65339507
12Folate biosynthesis_Homo sapiens_hsa007902.37182324
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.29804907
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22675680
15Taste transduction_Homo sapiens_hsa047422.15051949
16Ovarian steroidogenesis_Homo sapiens_hsa049131.69725859
17Mismatch repair_Homo sapiens_hsa034301.62347580
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.55723236
19Fanconi anemia pathway_Homo sapiens_hsa034601.53178406
20Homologous recombination_Homo sapiens_hsa034401.35688718
21Sulfur metabolism_Homo sapiens_hsa009201.30640749
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29668395
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24505603
24MicroRNAs in cancer_Homo sapiens_hsa052061.23309928
25Caffeine metabolism_Homo sapiens_hsa002321.22788243
26Base excision repair_Homo sapiens_hsa034101.21243202
27Viral carcinogenesis_Homo sapiens_hsa052031.21212405
28RNA degradation_Homo sapiens_hsa030181.17889321
29Fatty acid elongation_Homo sapiens_hsa000621.15361925
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13815916
31Pyrimidine metabolism_Homo sapiens_hsa002401.11215840
32DNA replication_Homo sapiens_hsa030301.03259000
33Cardiac muscle contraction_Homo sapiens_hsa042601.01421370
34Epstein-Barr virus infection_Homo sapiens_hsa051691.01072957
35Huntingtons disease_Homo sapiens_hsa050161.00617628
36Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90460433
37Herpes simplex infection_Homo sapiens_hsa051680.88668987
38Purine metabolism_Homo sapiens_hsa002300.88445802
39Inositol phosphate metabolism_Homo sapiens_hsa005620.85506838
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85345106
41Nucleotide excision repair_Homo sapiens_hsa034200.83187826
42Hepatitis B_Homo sapiens_hsa051610.81336424
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77800983
44Wnt signaling pathway_Homo sapiens_hsa043100.77522258
45Dorso-ventral axis formation_Homo sapiens_hsa043200.75192167
46Small cell lung cancer_Homo sapiens_hsa052220.75025884
47Olfactory transduction_Homo sapiens_hsa047400.73070992
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70129753
49Acute myeloid leukemia_Homo sapiens_hsa052210.66500343
50Steroid biosynthesis_Homo sapiens_hsa001000.65907345
51Arginine and proline metabolism_Homo sapiens_hsa003300.60273207
52AMPK signaling pathway_Homo sapiens_hsa041520.59642388
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.53013881
54Fatty acid biosynthesis_Homo sapiens_hsa000610.52053201
55Nicotine addiction_Homo sapiens_hsa050330.52012221
56Insulin secretion_Homo sapiens_hsa049110.51426266
57Systemic lupus erythematosus_Homo sapiens_hsa053220.51204438
58ABC transporters_Homo sapiens_hsa020100.48894233
59FoxO signaling pathway_Homo sapiens_hsa040680.47013070
60Bile secretion_Homo sapiens_hsa049760.46415803
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42810365
62Protein digestion and absorption_Homo sapiens_hsa049740.41728484
63TGF-beta signaling pathway_Homo sapiens_hsa043500.37617996
64Parkinsons disease_Homo sapiens_hsa050120.36611488
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36236777
66Mineral absorption_Homo sapiens_hsa049780.34654953
67Alcoholism_Homo sapiens_hsa050340.34274949
68Prostate cancer_Homo sapiens_hsa052150.31626135
69GABAergic synapse_Homo sapiens_hsa047270.31613410
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.31598627
71Serotonergic synapse_Homo sapiens_hsa047260.31386627
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31228922
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27941352
74Influenza A_Homo sapiens_hsa051640.26489955
75Renal cell carcinoma_Homo sapiens_hsa052110.26360180
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25580132
77Amphetamine addiction_Homo sapiens_hsa050310.24612640
78Hippo signaling pathway_Homo sapiens_hsa043900.24431831
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21905631
80Morphine addiction_Homo sapiens_hsa050320.21726748
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21408308
82Legionellosis_Homo sapiens_hsa051340.21027730
83Pathways in cancer_Homo sapiens_hsa052000.19385317
84mTOR signaling pathway_Homo sapiens_hsa041500.19076328
85Circadian rhythm_Homo sapiens_hsa047100.17377849
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14210672
87Adherens junction_Homo sapiens_hsa045200.12795769
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11232723
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09842488
90Tight junction_Homo sapiens_hsa045300.09634393
91Glutathione metabolism_Homo sapiens_hsa004800.08945734
92HTLV-I infection_Homo sapiens_hsa051660.08371620
93Pancreatic secretion_Homo sapiens_hsa049720.07913853
94Protein export_Homo sapiens_hsa030600.06287874
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05986076
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03734293
97MAPK signaling pathway_Homo sapiens_hsa040100.03322887
98Sphingolipid metabolism_Homo sapiens_hsa006000.02239204
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.01942908
100Metabolic pathways_Homo sapiens_hsa011000.01826138

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