ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	6.38537597
2	meiosis I (GO:0007127)	5.48111185
3	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	43.8663794
4	regulation of acrosome reaction (GO:0060046)	4.49497658
5	regulation of DNA methylation (GO:0044030)	4.41044970
6	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.34091948
7	regulation of retinoic acid receptor signaling pathway (GO:0048385)	36.6998330
8	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.94517440
9	regulation of female gonad development (GO:2000194)	3.74107019
10	mitotic chromosome condensation (GO:0007076)	3.72685960
11	multicellular organism reproduction (GO:0032504)	3.53353511
12	male meiosis (GO:0007140)	3.47961988
13	regulation of female receptivity (GO:0045924)	3.45212467
14	aggressive behavior (GO:0002118)	3.45094068
15	drinking behavior (GO:0042756)	3.28526853
16	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.16771139
17	regulation of penile erection (GO:0060405)	3.12500688
18	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.10590263
19	transcription from mitochondrial promoter (GO:0006390)	3.03150864
20	regulation of uterine smooth muscle contraction (GO:0070472)	3.03072418
21	hyperosmotic salinity response (GO:0042538)	3.02124733
22	regulation of histone H3-K9 methylation (GO:0051570)	3.02046864
23	female mating behavior (GO:0060180)	2.96785250
24	mitotic metaphase plate congression (GO:0007080)	2.94354093
25	positive regulation of prostaglandin secretion (GO:0032308)	2.92485714
26	response to acidic pH (GO:0010447)	2.87380156
27	oocyte development (GO:0048599)	2.86844443
28	protein kinase C signaling (GO:0070528)	2.85695587
29	regulation of mitotic spindle organization (GO:0060236)	2.81800481
30	regulation of spindle organization (GO:0090224)	2.77265808
31	positive regulation of humoral immune response (GO:0002922)	2.76248576
32	ribosome assembly (GO:0042255)	2.75840929
33	negative regulation of reproductive process (GO:2000242)	2.75309112
34	positive regulation of digestive system process (GO:0060456)	2.74527535
35	sleep (GO:0030431)	2.74022531
36	positive regulation of catecholamine secretion (GO:0033605)	2.72680529
37	negative regulation of digestive system process (GO:0060457)	2.71722838
38	maturation of SSU-rRNA (GO:0030490)	2.63697489
39	protein localization to chromosome, centromeric region (GO:0071459)	2.60959146
40	cellular response to pH (GO:0071467)	2.59914465
41	meiotic nuclear division (GO:0007126)	2.52629268
42	meiotic cell cycle (GO:0051321)	2.52012044
43	regulation of prostaglandin secretion (GO:0032306)	2.47573477
44	snRNA transcription (GO:0009301)	2.47496228
45	autophagic vacuole assembly (GO:0000045)	2.46493332
46	attachment of spindle microtubules to kinetochore (GO:0008608)	2.45488151
47	rRNA modification (GO:0000154)	2.43818396
48	positive regulation of histone H3-K4 methylation (GO:0051571)	2.42751250
49	chromosome condensation (GO:0030261)	2.42548200
50	telomere maintenance via telomere lengthening (GO:0010833)	2.40032057
51	glycine transport (GO:0015816)	2.37165290
52	ventricular cardiac muscle cell development (GO:0055015)	2.35578479
53	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.33858350
54	regulation of RNA export from nucleus (GO:0046831)	2.31994499
55	metaphase plate congression (GO:0051310)	2.31969790
56	reproduction (GO:0000003)	2.31901748
57	chaperone-mediated protein transport (GO:0072321)	2.31213402
58	negative regulation of histone methylation (GO:0031061)	2.29967064
59	positive regulation of protein homooligomerization (GO:0032464)	2.29760934
60	polyamine biosynthetic process (GO:0006596)	2.28132721
61	regulation of exit from mitosis (GO:0007096)	2.26208960
62	oocyte maturation (GO:0001556)	2.24553614
63	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.23189532
64	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.22501974
65	meiotic cell cycle process (GO:1903046)	2.18207960
66	muscle organ morphogenesis (GO:0048644)	2.16305017
67	nuclear pore complex assembly (GO:0051292)	2.14651962
68	nuclear pore organization (GO:0006999)	2.12668133
69	maternal behavior (GO:0042711)	2.12647955
70	regulation of G0 to G1 transition (GO:0070316)	2.12298468
71	positive regulation of cytokinesis (GO:0032467)	2.10420957
72	histone H3-K9 demethylation (GO:0033169)	2.10195953
73	primitive streak formation (GO:0090009)	2.09343452
74	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.08813494
75	N-terminal protein amino acid acetylation (GO:0006474)	2.08218159
76	retinal cone cell development (GO:0046549)	2.07210862
77	regulation of norepinephrine secretion (GO:0014061)	2.05356744
78	positive regulation of reproductive process (GO:2000243)	2.05304536
79	regulation of cell cycle G2/M phase transition (GO:1902749)	2.05120479
80	response to food (GO:0032094)	2.03307868
81	kinetochore assembly (GO:0051382)	2.02522021
82	DNA replication initiation (GO:0006270)	2.01366123
83	rRNA methylation (GO:0031167)	2.00079071
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.00065482
85	termination of RNA polymerase III transcription (GO:0006386)	2.00065482
86	binding of sperm to zona pellucida (GO:0007339)	1.99825876
87	positive regulation of chromosome segregation (GO:0051984)	1.98633057
88	DNA packaging (GO:0006323)	1.96917555
89	protein K6-linked ubiquitination (GO:0085020)	1.96296283
90	regulation of helicase activity (GO:0051095)	1.91778673
91	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	1.91412887
92	regulation of meiosis I (GO:0060631)	1.90428526
93	androgen receptor signaling pathway (GO:0030521)	1.87626887
94	regulation of histone methylation (GO:0031060)	1.87239839
95	parental behavior (GO:0060746)	1.86341348
96	regulation of nucleobase-containing compound transport (GO:0032239)	1.85489570
97	piRNA metabolic process (GO:0034587)	1.83851692
98	negative regulation of meiosis (GO:0045835)	1.82750721
99	L-amino acid import (GO:0043092)	1.82159716
100	skeletal muscle tissue regeneration (GO:0043403)	1.81355386

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	6.29178519
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.70457213
3	EZH2_22144423_ChIP-Seq_EOC_Human	5.60499925
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	5.46474101
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	5.46474101
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	5.46474101
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.09646155
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.76142864
9	E2F7_22180533_ChIP-Seq_HELA_Human	3.94162644
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.55394414
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.36538785
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.35626701
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.26428560
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.90353398
15	ETV1_20927104_ChIP-Seq_GIST48_Human	2.86875374
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84027125
17	RBPJ_21746931_ChIP-Seq_IB4_Human	2.65422299
18	TBL1_22424771_ChIP-Seq_293T_Human	2.42081501
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.40462336
20	NFYB_21822215_ChIP-Seq_K562_Human	2.32916013
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.29759179
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27054828
23	PHF8_20622853_ChIP-Seq_HELA_Human	2.24684252
24	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	2.13766099
25	AR_21909140_ChIP-Seq_LNCAP_Human	2.09015900
26	GATA6_21074721_ChIP-Seq_CACO-2_Human	2.06280487
27	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.99061633
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.95934876
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.95120598
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91977119
31	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.78884953
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75341605
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74875876
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.62242961
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.53043954
36	NFYA_21822215_ChIP-Seq_K562_Human	1.50232486
37	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.48885517
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.45706264
39	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.43526077
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.37563923
41	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.33667376
42	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.30374602
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.25927934
44	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.24551892
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.20224758
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.16537704
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16197790
48	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16008127
49	RAC3_21632823_ChIP-Seq_H3396_Human	1.15975748
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15174675
51	* MYC_18940864_ChIP-ChIP_HL60_Human	1.10738164
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.05282516
53	STAT1_20625510_ChIP-Seq_HELA_Human	1.04741731
54	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98255610
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.98244294
56	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.97082735
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96278785
58	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93263694
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.92786952
60	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.92391747
61	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.90290110
62	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.89076713
63	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.88567354
64	SOX2_21211035_ChIP-Seq_LN229_Human	0.87897963
65	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87469182
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87432019
67	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.85542483
68	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.85440135
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.82972243
70	GABP_19822575_ChIP-Seq_HepG2_Human	0.81403930
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.79879617
72	FOXP3_21729870_ChIP-Seq_TREG_Human	0.79204553
73	ELK1_19687146_ChIP-ChIP_HELA_Human	0.78827554
74	TP53_22573176_ChIP-Seq_HFKS_Human	0.78811824
75	E2F1_20622854_ChIP-Seq_HELA_Human	0.77797839
76	CTCF_20526341_ChIP-Seq_ESCs_Human	0.76609961
77	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.76527874
78	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.75291512
79	ZNF263_19887448_ChIP-Seq_K562_Human	0.73580166
80	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.73297648
81	IRF1_19129219_ChIP-ChIP_H3396_Human	0.72250341
82	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.72118143
83	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.72023175
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.71785526
85	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.69820219
86	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.69704661
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.69699635
88	CIITA_25753668_ChIP-Seq_RAJI_Human	0.69311605
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.66632856
90	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.66544357
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.66187737
92	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.66067795
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.64199968
94	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.63095529
95	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.62943218
96	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.62908946
97	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.62821296
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.62774118
99	KDM5A_27292631_Chip-Seq_BREAST_Human	0.60821879
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.58898179

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.23989292
2	MP0003718_maternal_effect	5.02885989
3	MP0001986_abnormal_taste_sensitivity	4.95886787
4	MP0005423_abnormal_somatic_nervous	4.58546899
5	MP0005499_abnormal_olfactory_system	3.68764082
6	MP0005394_taste/olfaction_phenotype	3.68764082
7	MP0010307_abnormal_tumor_latency	3.29357678
8	MP0009379_abnormal_foot_pigmentation	3.01587502
9	MP0002127_abnormal_cardiovascular_syste	2.78730921
10	MP0010030_abnormal_orbit_morphology	2.75045713
11	MP0002277_abnormal_respiratory_mucosa	2.71554839
12	MP0003693_abnormal_embryo_hatching	2.68661188
13	MP0008057_abnormal_DNA_replication	2.63451103
14	MP0002160_abnormal_reproductive_system	2.38636202
15	MP0004957_abnormal_blastocyst_morpholog	2.36858211
16	MP0003111_abnormal_nucleus_morphology	2.36837767
17	MP0008789_abnormal_olfactory_epithelium	2.31241048
18	MP0003077_abnormal_cell_cycle	2.26436746
19	MP0001929_abnormal_gametogenesis	2.25391497
20	MP0005410_abnormal_fertilization	2.25080574
21	MP0008877_abnormal_DNA_methylation	2.21913780
22	MP0002210_abnormal_sex_determination	2.17214741
23	MP0010094_abnormal_chromosome_stability	2.02780463
24	MP0005395_other_phenotype	2.02620594
25	MP0002138_abnormal_hepatobiliary_system	2.00277650
26	MP0001881_abnormal_mammary_gland	1.90819986
27	MP0009333_abnormal_splenocyte_physiolog	1.82351379
28	MP0002254_reproductive_system_inflammat	1.80764112
29	MP0008058_abnormal_DNA_repair	1.78749033
30	MP0006276_abnormal_autonomic_nervous	1.72539146
31	MP0003121_genomic_imprinting	1.71367616
32	MP0003699_abnormal_female_reproductive	1.67792813
33	MP0005389_reproductive_system_phenotype	1.63227167
34	MP0005360_urolithiasis	1.62586307
35	MP0009840_abnormal_foam_cell	1.54237266
36	MP0002161_abnormal_fertility/fecundity	1.48870668
37	MP0003136_yellow_coat_color	1.46939219
38	MP0000653_abnormal_sex_gland	1.45644448
39	MP0002234_abnormal_pharynx_morphology	1.45497215
40	MP0005647_abnormal_sex_gland	1.41933914
41	MP0001293_anophthalmia	1.41018715
42	MP0008260_abnormal_autophagy	1.36217970
43	MP0003698_abnormal_male_reproductive	1.35275305
44	MP0001672_abnormal_embryogenesis/_devel	1.31148042
45	MP0005380_embryogenesis_phenotype	1.31148042
46	MP0008932_abnormal_embryonic_tissue	1.29806500
47	MP0001145_abnormal_male_reproductive	1.24864282
48	MP0005646_abnormal_pituitary_gland	1.21953993
49	MP0002233_abnormal_nose_morphology	1.19098300
50	MP0001502_abnormal_circadian_rhythm	1.15901353
51	MP0000350_abnormal_cell_proliferation	1.15350894
52	MP0010368_abnormal_lymphatic_system	1.15160202
53	MP0001730_embryonic_growth_arrest	1.14182155
54	MP0003195_calcinosis	1.07177917
55	MP0000372_irregular_coat_pigmentation	1.07015485
56	MP0001545_abnormal_hematopoietic_system	1.06709577
57	MP0005397_hematopoietic_system_phenotyp	1.06709577
58	MP0000049_abnormal_middle_ear	1.06681179
59	MP0003984_embryonic_growth_retardation	1.04889901
60	MP0000762_abnormal_tongue_morphology	1.03434716
61	MP0003646_muscle_fatigue	1.00304324
62	MP0002088_abnormal_embryonic_growth/wei	0.98491412
63	MP0000627_abnormal_mammary_gland	0.96939069
64	MP0003890_abnormal_embryonic-extraembry	0.89311055
65	MP0003938_abnormal_ear_development	0.89101819
66	MP0001119_abnormal_female_reproductive	0.88508827
67	MP0001697_abnormal_embryo_size	0.82350948
68	MP0006036_abnormal_mitochondrial_physio	0.78672372
69	MP0000428_abnormal_craniofacial_morphol	0.76098811
70	MP0003936_abnormal_reproductive_system	0.75120532
71	MP0003755_abnormal_palate_morphology	0.75025456
72	MP0003828_pulmonary_edema	0.74892500
73	MP0003950_abnormal_plasma_membrane	0.74550674
74	MP0008995_early_reproductive_senescence	0.72433301
75	MP0004381_abnormal_hair_follicle	0.72374117
76	MP0003879_abnormal_hair_cell	0.72118578
77	MP0005197_abnormal_uvea_morphology	0.70093388
78	MP0002751_abnormal_autonomic_nervous	0.68754088
79	MP0000631_abnormal_neuroendocrine_gland	0.68025654
80	MP0004215_abnormal_myocardial_fiber	0.67028628
81	MP0000358_abnormal_cell_content/	0.66161224
82	MP0002080_prenatal_lethality	0.64930643
83	MP0004142_abnormal_muscle_tone	0.63029478
84	MP0002139_abnormal_hepatobiliary_system	0.62075817
85	MP0002084_abnormal_developmental_patter	0.61155392
86	MP0002873_normal_phenotype	0.60653526
87	MP0002169_no_abnormal_phenotype	0.60496141
88	MP0001286_abnormal_eye_development	0.60453771
89	MP0001666_abnormal_nutrient_absorption	0.60188776
90	MP0002085_abnormal_embryonic_tissue	0.60182084
91	MP0003123_paternal_imprinting	0.57259448
92	MP0001919_abnormal_reproductive_system	0.56374448
93	MP0005451_abnormal_body_composition	0.52003527
94	MP0003119_abnormal_digestive_system	0.49519795
95	MP0002086_abnormal_extraembryonic_tissu	0.47272626
96	MP0003935_abnormal_craniofacial_develop	0.43355742
97	MP0000313_abnormal_cell_death	0.41345964
98	MP0001440_abnormal_grooming_behavior	0.41222508
99	MP0004019_abnormal_vitamin_homeostasis	0.40718395
100	MP0004808_abnormal_hematopoietic_stem	0.39850746

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	8.16121340
2	Malnutrition (HP:0004395)	6.48977860
3	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.43289297
4	Premature ovarian failure (HP:0008209)	4.77731594
5	Hypercortisolism (HP:0001578)	4.33312510
6	Carpal bone hypoplasia (HP:0001498)	4.19232829
7	Aplasia/hypoplasia of the uterus (HP:0008684)	4.11453533
8	Impulsivity (HP:0100710)	4.09892453
9	Abnormality of the septum pellucidum (HP:0007375)	3.95401485
10	Preauricular pit (HP:0004467)	3.93140861
11	Periauricular skin pits (HP:0100277)	3.93140861
12	Hypophosphatemic rickets (HP:0004912)	3.60546328
13	Septo-optic dysplasia (HP:0100842)	3.57849765
14	Patent foramen ovale (HP:0001655)	3.57597300
15	Rhinitis (HP:0012384)	3.53077723
16	Birth length less than 3rd percentile (HP:0003561)	3.42403112
17	Abdominal situs inversus (HP:0003363)	3.39275208
18	Abnormality of abdominal situs (HP:0011620)	3.39275208
19	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.36113038
20	Infertility (HP:0000789)	3.35797101
21	Muscle stiffness (HP:0003552)	3.35589923
22	Myokymia (HP:0002411)	3.34575538
23	Aplasia/hypoplasia of the humerus (HP:0006507)	3.29391785
24	Absent septum pellucidum (HP:0001331)	3.20045172
25	Steatorrhea (HP:0002570)	3.18012798
26	Hypoplasia of the uterus (HP:0000013)	3.14178341
27	Midline defect of the nose (HP:0004122)	2.97285681
28	Sensory axonal neuropathy (HP:0003390)	2.92331716
29	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.90472535
30	Short tibia (HP:0005736)	2.90330455
31	Fat malabsorption (HP:0002630)	2.76709362
32	Tetraparesis (HP:0002273)	2.70951120
33	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.70259607
34	Meckel diverticulum (HP:0002245)	2.69307772
35	Abnormal pancreas size (HP:0012094)	2.67239477
36	Skin pits (HP:0100276)	2.65161051
37	Reticulocytopenia (HP:0001896)	2.60333631
38	Chromsome breakage (HP:0040012)	2.60292184
39	Ureteral duplication (HP:0000073)	2.59947867
40	Abnormality of the preputium (HP:0100587)	2.59637370
41	Progressive sensorineural hearing impairment (HP:0000408)	2.59466721
42	Abnormality of the ileum (HP:0001549)	2.59163487
43	Mitral stenosis (HP:0001718)	2.57886674
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.56737443
45	Apathy (HP:0000741)	2.55863921
46	Congenital malformation of the right heart (HP:0011723)	2.54477943
47	Double outlet right ventricle (HP:0001719)	2.54477943
48	Sparse lateral eyebrow (HP:0005338)	2.52039613
49	Adrenal overactivity (HP:0002717)	2.50171786
50	Hypergonadotropic hypogonadism (HP:0000815)	2.49637073
51	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.48537537
52	Hypoplastic scapulae (HP:0000882)	2.48537537
53	Facial cleft (HP:0002006)	2.48378620
54	Abnormality of the fetal cardiovascular system (HP:0010948)	2.44189004
55	Abnormal umbilical cord blood vessels (HP:0011403)	2.44189004
56	Single umbilical artery (HP:0001195)	2.44189004
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.42475218
58	Hypoplasia of the fovea (HP:0007750)	2.42475218
59	Dysphonia (HP:0001618)	2.39687806
60	Osteomalacia (HP:0002749)	2.39394374
61	Hypoglycemic seizures (HP:0002173)	2.39093329
62	Microretrognathia (HP:0000308)	2.35384855
63	Constricted visual fields (HP:0001133)	2.33943692
64	Cortical visual impairment (HP:0100704)	2.33403299
65	Fused cervical vertebrae (HP:0002949)	2.30409533
66	Progressive hearing impairment (HP:0001730)	2.30230133
67	Absent radius (HP:0003974)	2.29790646
68	Glossoptosis (HP:0000162)	2.29636500
69	Cleft eyelid (HP:0000625)	2.26084001
70	Selective tooth agenesis (HP:0001592)	2.21820003
71	Diminished motivation (HP:0000745)	2.21751707
72	Delayed CNS myelination (HP:0002188)	2.16674090
73	Absent forearm bone (HP:0003953)	2.16442861
74	Aplasia involving forearm bones (HP:0009822)	2.16442861
75	Testicular atrophy (HP:0000029)	2.13449271
76	Atresia of the external auditory canal (HP:0000413)	2.13301756
77	Attenuation of retinal blood vessels (HP:0007843)	2.12682201
78	Short humerus (HP:0005792)	2.10358219
79	Abnormal number of incisors (HP:0011064)	2.07739095
80	Horseshoe kidney (HP:0000085)	2.07297258
81	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.06139391
82	Maternal diabetes (HP:0009800)	2.05661745
83	Progressive muscle weakness (HP:0003323)	2.04531684
84	Multiple enchondromatosis (HP:0005701)	2.03963889
85	Stenosis of the external auditory canal (HP:0000402)	2.03928181
86	Chronic sinusitis (HP:0011109)	2.02118207
87	Anterior segment dysgenesis (HP:0007700)	2.00395853
88	Congenital ichthyosiform erythroderma (HP:0007431)	2.00060867
89	Azoospermia (HP:0000027)	1.99102364
90	Abnormality of the pubic bones (HP:0003172)	1.97843330
91	Limb dystonia (HP:0002451)	1.93238234
92	Absent thumb (HP:0009777)	1.92214057
93	Nausea (HP:0002018)	1.91611050
94	Abnormal ciliary motility (HP:0012262)	1.91596051
95	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.90900965
96	Concave nail (HP:0001598)	1.86608444
97	Increased circulating renin level (HP:0000848)	1.85724345
98	Fibular aplasia (HP:0002990)	1.84886478
99	Gonadotropin excess (HP:0000837)	1.83242237
100	Spinal cord lesions (HP:0100561)	1.83189564

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS2	5.44321438
2	TESK2	5.41298998
3	SRPK1	4.29938633
4	BUB1	4.20689481
5	TRIM28	3.30480248
6	NEK6	3.15020969
7	CDK9	2.77796866
8	DYRK3	2.66778329
9	CDK19	2.40638909
10	STK16	2.34469592
11	PLK1	2.34194361
12	BRSK1	2.30185899
13	BRSK2	2.12052611
14	CDC7	2.04006374
15	CDK12	1.95574322
16	PIM2	1.95268846
17	TAOK3	1.85711960
18	AURKB	1.83876020
19	PLK3	1.75350939
20	MARK3	1.74609221
21	MAP3K9	1.59234664
22	PBK	1.57501076
23	PRKCI	1.53699576
24	GSK3A	1.52254007
25	CDK7	1.52063335
26	AURKA	1.49866605
27	WNK3	1.33898008
28	NEK2	1.31756669
29	CHEK1	1.30544608
30	RAF1	1.29715434
31	PDK2	1.22047143
32	CSNK1E	1.21895039
33	PIM1	1.13115099
34	MELK	1.12763031
35	TTK	1.08286155
36	WNK1	1.06304423
37	LRRK2	1.03840513
38	MAP3K5	1.02973553
39	PKN1	0.97073399
40	ZAK	0.91526481
41	BRD4	0.89918339
42	PAK2	0.88649609
43	CDK2	0.87183081
44	PLK4	0.86397357
45	NTRK3	0.85032974
46	EIF2AK3	0.84576832
47	STK3	0.83237845
48	TLK1	0.83002462
49	CSNK2A2	0.82291821
50	CSNK2A1	0.76584560
51	CHEK2	0.75619961
52	MTOR	0.75182225
53	CDK1	0.74879888
54	ATR	0.73209133
55	PAK1	0.72788404
56	STK24	0.71363003
57	STK4	0.70230312
58	TNIK	0.66297243
59	WEE1	0.65120154
60	NME1	0.52986469
61	ATM	0.52506850
62	PRKG1	0.47337705
63	TAOK2	0.46434612
64	GSK3B	0.46295322
65	KDR	0.44853298
66	TBK1	0.43614605
67	MAPK11	0.41742942
68	MAPK1	0.40359607
69	CSNK1D	0.39583086
70	DMPK	0.39348939
71	AKT2	0.38405847
72	TESK1	0.37988510
73	PRKACB	0.37132320
74	MAPK14	0.36314140
75	CLK1	0.32857060
76	PRKD1	0.32732330
77	RPS6KA1	0.30724065
78	VRK1	0.29368357
79	STK10	0.28600049
80	MAPK10	0.28053278
81	CDK5	0.26987126
82	MAP3K4	0.26667544
83	ARAF	0.26230871
84	TIE1	0.25628426
85	CDK11A	0.25014117
86	MAP3K8	0.24682063
87	ABL2	0.22733187
88	PRKAA1	0.22210299
89	PRPF4B	0.21640110
90	CAMK1	0.20299231
91	TSSK6	0.20049302
92	LMTK2	0.19780340
93	DYRK1A	0.19778232
94	PRKACA	0.19756671
95	CDK3	0.19473762
96	MAPK4	0.18068245
97	EIF2AK2	0.17652986
98	PRKD2	0.17296965
99	PLK2	0.16350750
100	CSNK1A1	0.15982022

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	6.38679833
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.16357899
3	mRNA surveillance pathway_Homo sapiens_hsa03015	3.89720153
4	Regulation of autophagy_Homo sapiens_hsa04140	3.78288608
5	Cell cycle_Homo sapiens_hsa04110	3.45898391
6	RNA polymerase_Homo sapiens_hsa03020	3.43421346
7	Ribosome_Homo sapiens_hsa03010	3.07512068
8	RNA transport_Homo sapiens_hsa03013	2.99654141
9	p53 signaling pathway_Homo sapiens_hsa04115	2.94627999
10	Oocyte meiosis_Homo sapiens_hsa04114	2.67962981
11	Spliceosome_Homo sapiens_hsa03040	2.65339507
12	Folate biosynthesis_Homo sapiens_hsa00790	2.37182324
13	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.29804907
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.22675680
15	Taste transduction_Homo sapiens_hsa04742	2.15051949
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.69725859
17	Mismatch repair_Homo sapiens_hsa03430	1.62347580
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.55723236
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53178406
20	Homologous recombination_Homo sapiens_hsa03440	1.35688718
21	Sulfur metabolism_Homo sapiens_hsa00920	1.30640749
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.29668395
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.24505603
24	MicroRNAs in cancer_Homo sapiens_hsa05206	1.23309928
25	Caffeine metabolism_Homo sapiens_hsa00232	1.22788243
26	Base excision repair_Homo sapiens_hsa03410	1.21243202
27	Viral carcinogenesis_Homo sapiens_hsa05203	1.21212405
28	RNA degradation_Homo sapiens_hsa03018	1.17889321
29	Fatty acid elongation_Homo sapiens_hsa00062	1.15361925
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13815916
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11215840
32	DNA replication_Homo sapiens_hsa03030	1.03259000
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01421370
34	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.01072957
35	Huntingtons disease_Homo sapiens_hsa05016	1.00617628
36	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.90460433
37	Herpes simplex infection_Homo sapiens_hsa05168	0.88668987
38	Purine metabolism_Homo sapiens_hsa00230	0.88445802
39	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.85506838
40	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.85345106
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.83187826
42	Hepatitis B_Homo sapiens_hsa05161	0.81336424
43	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.77800983
44	Wnt signaling pathway_Homo sapiens_hsa04310	0.77522258
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75192167
46	Small cell lung cancer_Homo sapiens_hsa05222	0.75025884
47	Olfactory transduction_Homo sapiens_hsa04740	0.73070992
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.70129753
49	Acute myeloid leukemia_Homo sapiens_hsa05221	0.66500343
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.65907345
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60273207
52	AMPK signaling pathway_Homo sapiens_hsa04152	0.59642388
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53013881
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52053201
55	Nicotine addiction_Homo sapiens_hsa05033	0.52012221
56	Insulin secretion_Homo sapiens_hsa04911	0.51426266
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51204438
58	ABC transporters_Homo sapiens_hsa02010	0.48894233
59	FoxO signaling pathway_Homo sapiens_hsa04068	0.47013070
60	Bile secretion_Homo sapiens_hsa04976	0.46415803
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42810365
62	Protein digestion and absorption_Homo sapiens_hsa04974	0.41728484
63	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37617996
64	Parkinsons disease_Homo sapiens_hsa05012	0.36611488
65	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36236777
66	Mineral absorption_Homo sapiens_hsa04978	0.34654953
67	Alcoholism_Homo sapiens_hsa05034	0.34274949
68	Prostate cancer_Homo sapiens_hsa05215	0.31626135
69	GABAergic synapse_Homo sapiens_hsa04727	0.31613410
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31598627
71	Serotonergic synapse_Homo sapiens_hsa04726	0.31386627
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31228922
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27941352
74	Influenza A_Homo sapiens_hsa05164	0.26489955
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.26360180
76	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.25580132
77	Amphetamine addiction_Homo sapiens_hsa05031	0.24612640
78	Hippo signaling pathway_Homo sapiens_hsa04390	0.24431831
79	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.21905631
80	Morphine addiction_Homo sapiens_hsa05032	0.21726748
81	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.21408308
82	Legionellosis_Homo sapiens_hsa05134	0.21027730
83	Pathways in cancer_Homo sapiens_hsa05200	0.19385317
84	mTOR signaling pathway_Homo sapiens_hsa04150	0.19076328
85	Circadian rhythm_Homo sapiens_hsa04710	0.17377849
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.14210672
87	Adherens junction_Homo sapiens_hsa04520	0.12795769
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.11232723
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.09842488
90	Tight junction_Homo sapiens_hsa04530	0.09634393
91	Glutathione metabolism_Homo sapiens_hsa00480	0.08945734
92	HTLV-I infection_Homo sapiens_hsa05166	0.08371620
93	Pancreatic secretion_Homo sapiens_hsa04972	0.07913853
94	Protein export_Homo sapiens_hsa03060	0.06287874
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.05986076
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.03734293
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.03322887
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.02239204
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.01942908
100	Metabolic pathways_Homo sapiens_hsa01100	0.01826138

PRAMEF9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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