PRAMENP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.00745618
2B cell receptor signaling pathway (GO:0050853)6.96627027
3NIK/NF-kappaB signaling (GO:0038061)5.64329119
4regulation of B cell differentiation (GO:0045577)5.12113498
5positive regulation of vascular permeability (GO:0043117)5.10628180
6drinking behavior (GO:0042756)5.06961901
7positive regulation of gamma-delta T cell activation (GO:0046645)4.91643423
8positive regulation of B cell differentiation (GO:0045579)4.90989328
9negative regulation of necrotic cell death (GO:0060547)4.64761363
10B cell proliferation (GO:0042100)4.58176392
11snRNA transcription (GO:0009301)4.57232801
12mannose metabolic process (GO:0006013)4.38762373
13germinal center formation (GO:0002467)4.30461955
14immunoglobulin mediated immune response (GO:0016064)4.22455449
15peptide catabolic process (GO:0043171)4.12646779
16positive regulation of Rap GTPase activity (GO:0032854)4.04791043
17regulation of interferon-beta biosynthetic process (GO:0045357)3.96777764
18negative regulation of cell size (GO:0045792)3.96467953
19I-kappaB phosphorylation (GO:0007252)3.93928471
20determination of adult lifespan (GO:0008340)3.85445767
21antigen processing and presentation of endogenous antigen (GO:0019883)3.84532402
22nerve growth factor signaling pathway (GO:0038180)3.74406611
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69696722
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69445471
25negative regulation of response to food (GO:0032096)3.68944276
26negative regulation of appetite (GO:0032099)3.68944276
27negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.68415337
28negative regulation of T-helper cell differentiation (GO:0045623)3.68415337
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68332420
30T cell migration (GO:0072678)3.63000804
31Rap protein signal transduction (GO:0032486)3.59354040
32mature B cell differentiation (GO:0002335)3.58472893
33negative regulation of phagocytosis (GO:0050765)3.57844783
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.57604494
35regulation of gamma-delta T cell activation (GO:0046643)3.53029809
36negative regulation of digestive system process (GO:0060457)3.52557002
37positive regulation of granulocyte differentiation (GO:0030854)3.50622236
38B cell homeostasis (GO:0001782)3.47727434
39regulation of gamma-delta T cell differentiation (GO:0045586)3.45525853
40CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.42315135
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41971252
42B cell mediated immunity (GO:0019724)3.41253264
43regulation of T-helper 1 cell differentiation (GO:0045625)3.40405929
44regulation of Rap GTPase activity (GO:0032317)3.38603995
45regulation of appetite (GO:0032098)3.33086665
46negative regulation of cell killing (GO:0031342)3.32981069
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32981069
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.32114957
49response to type I interferon (GO:0034340)3.31579996
50type I interferon signaling pathway (GO:0060337)3.30829990
51cellular response to type I interferon (GO:0071357)3.30829990
52positive regulation of protein oligomerization (GO:0032461)3.26857133
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26021513
54positive regulation of interferon-alpha production (GO:0032727)3.22606233
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20621048
56regulation of alpha-beta T cell proliferation (GO:0046640)3.18482935
57negative regulation of alpha-beta T cell activation (GO:0046636)3.16993630
58regulation of germinal center formation (GO:0002634)3.14814990
59cytidine deamination (GO:0009972)3.14456844
60cytidine metabolic process (GO:0046087)3.14456844
61cytidine catabolic process (GO:0006216)3.14456844
62cellular response to nerve growth factor stimulus (GO:1990090)3.13477417
63response to nerve growth factor (GO:1990089)3.13477417
64B cell activation (GO:0042113)3.11482998
65pyrimidine ribonucleoside catabolic process (GO:0046133)3.10703674
66negative regulation of neurotransmitter secretion (GO:0046929)3.09440193
67regulation of B cell proliferation (GO:0030888)3.07698620
68hormone catabolic process (GO:0042447)3.07672789
69antigen receptor-mediated signaling pathway (GO:0050851)3.07475059
70regulation of T-helper 2 cell differentiation (GO:0045628)3.06654731
71defense response to protozoan (GO:0042832)3.06636438
72positive regulation of B cell activation (GO:0050871)3.06077389
73regulation of response to food (GO:0032095)3.04938109
74regulation of necrotic cell death (GO:0010939)3.04481591
75positive thymic T cell selection (GO:0045059)3.04148314
76Peyers patch development (GO:0048541)3.03327817
77mucosal-associated lymphoid tissue development (GO:0048537)3.03327817
78negative regulation of bone resorption (GO:0045779)3.00906275
79regulation of interferon-alpha production (GO:0032647)2.97166971
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94825961
81positive regulation of B cell proliferation (GO:0030890)2.93310761
82mononuclear cell proliferation (GO:0032943)2.90587699
83lymphocyte proliferation (GO:0046651)2.89909010
84interferon-gamma-mediated signaling pathway (GO:0060333)2.87253037
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.85795448
86regulation of B cell activation (GO:0050864)2.82149614
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82141410
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.82141410
89modulation by symbiont of host immune response (GO:0052553)2.82141410
90positive regulation by symbiont of host defense response (GO:0052509)2.82141410
91modulation by symbiont of host defense response (GO:0052031)2.82141410
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82141410
93hepatocyte apoptotic process (GO:0097284)2.80310529
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79560742
95T cell lineage commitment (GO:0002360)2.77531368
96leukocyte proliferation (GO:0070661)2.76457817
97T cell selection (GO:0045058)2.73084319
98positive regulation of protein deacetylation (GO:0090312)2.70336595
99positive T cell selection (GO:0043368)2.68207975
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.67948259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.29547611
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.94005766
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.81779005
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.31685281
5MYC_22102868_ChIP-Seq_BL_Human4.24003789
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.49153262
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37649043
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.25581912
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.10991416
10RUNX_20019798_ChIP-Seq_JUKART_Human2.91616607
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83191822
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.74346306
13MYB_26560356_Chip-Seq_TH2_Human2.70890529
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59517001
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.31293322
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31156800
17SPI1_23547873_ChIP-Seq_NB4_Human2.22351658
18MYB_26560356_Chip-Seq_TH1_Human2.22211842
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17810788
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12174388
21SCL_19346495_ChIP-Seq_HPC-7_Human2.07937045
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98077877
23IGF1R_20145208_ChIP-Seq_DFB_Human1.89435787
24GATA3_27048872_Chip-Seq_THYMUS_Human1.88813215
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87287441
26NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.86549029
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85725823
28CIITA_25753668_ChIP-Seq_RAJI_Human1.79645701
29GATA3_26560356_Chip-Seq_TH2_Human1.73619429
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.73299619
31SPI1_23127762_ChIP-Seq_K562_Human1.68867712
32VDR_24763502_ChIP-Seq_THP-1_Human1.64381794
33MAF_26560356_Chip-Seq_TH1_Human1.62367975
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61683315
35SMRT_27268052_Chip-Seq_Bcells_Human1.60883837
36UTX_26944678_Chip-Seq_JUKART_Human1.59494377
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.58843488
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56899822
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50141811
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49323834
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47350162
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45667722
43VDR_21846776_ChIP-Seq_THP-1_Human1.41467401
44GATA1_22025678_ChIP-Seq_K562_Human1.39754942
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38693512
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37029951
47MAF_26560356_Chip-Seq_TH2_Human1.34466997
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33852447
49FOXP3_21729870_ChIP-Seq_TREG_Human1.31513172
50PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29913581
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25551616
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19806171
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19410554
54E2F7_22180533_ChIP-Seq_HELA_Human1.18312312
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17644639
56VDR_23849224_ChIP-Seq_CD4+_Human1.16640539
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14365982
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14221485
59VDR_24787735_ChIP-Seq_THP-1_Human1.11750739
60SALL4_22934838_ChIP-ChIP_CD34+_Human1.11140707
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.10632356
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08074133
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07113949
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02688192
65GATA3_26560356_Chip-Seq_TH1_Human1.02096055
66MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98572499
67FOXM1_23109430_ChIP-Seq_U2OS_Human0.97740866
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97081502
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90889037
70P300_27268052_Chip-Seq_Bcells_Human0.89500972
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89175433
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87663304
73BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86899649
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86462304
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85761927
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83790397
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83447115
78E2F1_21310950_ChIP-Seq_MCF-7_Human0.82660025
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82573530
80BCL6_27268052_Chip-Seq_Bcells_Human0.80251949
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79928603
82PU_27001747_Chip-Seq_BMDM_Mouse0.78178442
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.77202882
84ERG_20517297_ChIP-Seq_VCAP_Human0.74741824
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73534017
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.73501936
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72624563
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.71881763
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71855520
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71845485
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71782840
92ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71774419
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.70849525
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.70601457
95CBP_20019798_ChIP-Seq_JUKART_Human0.70601457
96TCF7_22412390_ChIP-Seq_EML_Mouse0.69985891
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69024001
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68698206
99AR_21572438_ChIP-Seq_LNCaP_Human0.68369678
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68236208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.60759908
2MP0001835_abnormal_antigen_presentation4.12233650
3MP0005387_immune_system_phenotype4.11491878
4MP0001790_abnormal_immune_system4.11491878
5MP0001800_abnormal_humoral_immune3.89299890
6MP0005671_abnormal_response_to3.19353596
7MP0000685_abnormal_immune_system3.16138876
8MP0005000_abnormal_immune_tolerance3.01369711
9MP0003303_peritoneal_inflammation2.91563659
10MP0003763_abnormal_thymus_physiology2.88942963
11MP0002452_abnormal_antigen_presenting2.85804131
12MP0002723_abnormal_immune_serum2.76258508
13MP0002420_abnormal_adaptive_immunity2.59341289
14MP0001819_abnormal_immune_cell2.49072399
15MP0005310_abnormal_salivary_gland2.42412611
16MP0002398_abnormal_bone_marrow2.41935300
17MP0001986_abnormal_taste_sensitivity2.33549704
18MP0009785_altered_susceptibility_to2.24678453
19MP0002405_respiratory_system_inflammati2.20559375
20MP0000689_abnormal_spleen_morphology2.20483063
21MP0005025_abnormal_response_to2.18784552
22MP0000716_abnormal_immune_system2.15670704
23MP0008057_abnormal_DNA_replication2.13354548
24MP0002166_altered_tumor_susceptibility1.88133055
25MP0002722_abnormal_immune_system1.86224255
26MP0003436_decreased_susceptibility_to1.84570815
27MP0000013_abnormal_adipose_tissue1.83568374
28MP0002429_abnormal_blood_cell1.71771433
29MP0002419_abnormal_innate_immunity1.70554859
30MP0002138_abnormal_hepatobiliary_system1.68072439
31MP0001845_abnormal_inflammatory_respons1.54308554
32MP0000703_abnormal_thymus_morphology1.53965859
33MP0010094_abnormal_chromosome_stability1.53068197
34MP0002928_abnormal_bile_duct1.52838877
35MP0010155_abnormal_intestine_physiology1.49070394
36MP0003300_gastrointestinal_ulcer1.47911801
37MP0009333_abnormal_splenocyte_physiolog1.46572521
38MP0005464_abnormal_platelet_physiology1.45154896
39MP0002653_abnormal_ependyma_morphology1.40255729
40MP0001873_stomach_inflammation1.37761129
41MP0002148_abnormal_hypersensitivity_rea1.31826589
42MP0002009_preneoplasia1.26675800
43MP0005645_abnormal_hypothalamus_physiol1.26250184
44MP0000678_abnormal_parathyroid_gland1.24502926
45MP0005075_abnormal_melanosome_morpholog1.21915674
46MP0002006_tumorigenesis1.14276317
47MP0004808_abnormal_hematopoietic_stem1.13445397
48MP0002132_abnormal_respiratory_system1.10520141
49MP0003866_abnormal_defecation1.08688952
50MP0004381_abnormal_hair_follicle1.07273406
51MP0000015_abnormal_ear_pigmentation1.06751731
52MP0003252_abnormal_bile_duct1.05431809
53MP0000371_diluted_coat_color1.04745496
54MP0008469_abnormal_protein_level1.00977405
55MP0002822_catalepsy0.97411294
56MP0003724_increased_susceptibility_to0.96952748
57MP0005084_abnormal_gallbladder_morpholo0.96524885
58MP0004947_skin_inflammation0.94677994
59MP0002019_abnormal_tumor_incidence0.93069731
60MP0010386_abnormal_urinary_bladder0.90184713
61MP0002136_abnormal_kidney_physiology0.88780195
62MP0000003_abnormal_adipose_tissue0.87760414
63MP0001348_abnormal_lacrimal_gland0.86071645
64MP0002693_abnormal_pancreas_physiology0.82084835
65MP0005379_endocrine/exocrine_gland_phen0.81755966
66MP0003045_fibrosis0.80565237
67MP0003656_abnormal_erythrocyte_physiolo0.79929116
68MP0009764_decreased_sensitivity_to0.77680320
69MP0003077_abnormal_cell_cycle0.77659246
70MP0005410_abnormal_fertilization0.75152103
71MP0002735_abnormal_chemical_nociception0.73483683
72MP0001968_abnormal_touch/_nociception0.73234404
73MP0000372_irregular_coat_pigmentation0.73075389
74MP0002127_abnormal_cardiovascular_syste0.72265141
75MP0003111_abnormal_nucleus_morphology0.72254926
76MP0001853_heart_inflammation0.68827995
77MP0003183_abnormal_peptide_metabolism0.68626534
78MP0008872_abnormal_physiological_respon0.66983309
79MP0009115_abnormal_fat_cell0.66675548
80MP0008874_decreased_physiological_sensi0.65268696
81MP0006072_abnormal_retinal_apoptosis0.63683681
82MP0003787_abnormal_imprinting0.62031649
83MP0000313_abnormal_cell_death0.61940070
84MP0002095_abnormal_skin_pigmentation0.58836839
85MP0005551_abnormal_eye_electrophysiolog0.58761815
86MP0000465_gastrointestinal_hemorrhage0.58748677
87MP0000604_amyloidosis0.57859214
88MP0006036_abnormal_mitochondrial_physio0.57779939
89MP0000569_abnormal_digit_pigmentation0.56676290
90MP0009643_abnormal_urine_homeostasis0.56535755
91MP0002163_abnormal_gland_morphology0.56436935
92MP0008058_abnormal_DNA_repair0.54636351
93MP0000609_abnormal_liver_physiology0.54146140
94MP0003693_abnormal_embryo_hatching0.53967899
95MP0008877_abnormal_DNA_methylation0.51790070
96MP0005166_decreased_susceptibility_to0.50375902
97MP0005253_abnormal_eye_physiology0.49658983
98MP0005332_abnormal_amino_acid0.48156114
99MP0001663_abnormal_digestive_system0.45745342
100MP0001929_abnormal_gametogenesis0.45370157

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.84152626
2Gastrointestinal stroma tumor (HP:0100723)6.80419212
3Panhypogammaglobulinemia (HP:0003139)5.31223928
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.28049622
5Lymphopenia (HP:0001888)4.68692657
6Recurrent sinusitis (HP:0011108)4.47216306
7Abnormality of cells of the lymphoid lineage (HP:0012140)4.33769343
8Meningitis (HP:0001287)4.32519808
9Vasculitis (HP:0002633)4.19137226
10Colitis (HP:0002583)4.04528046
11Generalized aminoaciduria (HP:0002909)4.02765104
12Recurrent bronchitis (HP:0002837)3.85553633
13Abnormality of the costochondral junction (HP:0000919)3.82654730
14Chronic mucocutaneous candidiasis (HP:0002728)3.80272516
15Recurrent cutaneous fungal infections (HP:0011370)3.80272516
16Recurrent viral infections (HP:0004429)3.76068364
17Emphysema (HP:0002097)3.58837018
18Inflammation of the large intestine (HP:0002037)3.48781717
19Cellulitis (HP:0100658)3.45555837
20Lymphoma (HP:0002665)3.34914543
21Gastrointestinal inflammation (HP:0004386)3.34661135
22Papilloma (HP:0012740)3.24078102
23Verrucae (HP:0200043)3.24078102
24Abnormality of T cell physiology (HP:0011840)3.22242231
25Male infertility (HP:0003251)3.21580678
26IgM deficiency (HP:0002850)3.20532437
27Recurrent lower respiratory tract infections (HP:0002783)3.18047908
28Failure to thrive in infancy (HP:0001531)3.17840453
29Encephalitis (HP:0002383)3.14510923
30Hypophosphatemic rickets (HP:0004912)3.13203878
31Mediastinal lymphadenopathy (HP:0100721)3.09561057
32Osteomyelitis (HP:0002754)3.09328314
33Recurrent pneumonia (HP:0006532)3.07506266
34Recurrent fungal infections (HP:0002841)3.02015799
35Chronic sinusitis (HP:0011109)2.92497345
36Abnormality of T cells (HP:0002843)2.87957314
37Hypoglycemic seizures (HP:0002173)2.87772480
38Abnormality of B cell number (HP:0010975)2.80211567
39IgA deficiency (HP:0002720)2.77963769
40Viral hepatitis (HP:0006562)2.75941822
41Tetany (HP:0001281)2.74194739
42Leukopenia (HP:0001882)2.71886221
43Chronic otitis media (HP:0000389)2.71048322
44Acute hepatic failure (HP:0006554)2.67254848
45Recurrent skin infections (HP:0001581)2.66216459
46Restrictive lung disease (HP:0002091)2.65758109
47Increased IgM level (HP:0003496)2.60517780
48Abnormality of the prostate (HP:0008775)2.54431402
49Recurrent bacterial skin infections (HP:0005406)2.54366436
50B lymphocytopenia (HP:0010976)2.49245719
51Abnormality of small intestinal villus morphology (HP:0011472)2.45375949
52Villous atrophy (HP:0011473)2.45375949
53Exocrine pancreatic insufficiency (HP:0001738)2.43035995
54Polydipsia (HP:0001959)2.40223253
55Abnormal drinking behavior (HP:0030082)2.40223253
56Delayed puberty (HP:0000823)2.37783458
57Renal Fanconi syndrome (HP:0001994)2.37704102
58Recurrent abscess formation (HP:0002722)2.33771898
59IgG deficiency (HP:0004315)2.33129991
60Sepsis (HP:0100806)2.31110073
61Elevated erythrocyte sedimentation rate (HP:0003565)2.30610597
62Recurrent otitis media (HP:0000403)2.29075887
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.26876827
64Abnormality of macrophages (HP:0004311)2.25450085
65Eczematoid dermatitis (HP:0000976)2.18307145
66Neutropenia (HP:0001875)2.17002953
67Abnormality of T cell number (HP:0011839)2.16034134
68Prostate neoplasm (HP:0100787)2.12646716
69Bronchitis (HP:0012387)2.11475652
70Congenital primary aphakia (HP:0007707)2.10118889
71T lymphocytopenia (HP:0005403)2.09916945
72Chronic diarrhea (HP:0002028)2.04293611
73Gait imbalance (HP:0002141)2.04054937
74Acute lymphatic leukemia (HP:0006721)2.02166519
75Chronic obstructive pulmonary disease (HP:0006510)1.97126745
76Obstructive lung disease (HP:0006536)1.97126745
77Carpal bone hypoplasia (HP:0001498)1.97028236
78Pulmonary infiltrates (HP:0002113)1.96971313
79Medial flaring of the eyebrow (HP:0010747)1.93585452
80Gastrointestinal infarctions (HP:0005244)1.92686104
81Type I diabetes mellitus (HP:0100651)1.90401874
82Spontaneous hematomas (HP:0007420)1.88459812
83Abnormality of fatty-acid metabolism (HP:0004359)1.88386469
84Urticaria (HP:0001025)1.85920292
85Nephrogenic diabetes insipidus (HP:0009806)1.84778650
86Recurrent gram-negative bacterial infections (HP:0005420)1.81833306
87Basal cell carcinoma (HP:0002671)1.78941506
88Albinism (HP:0001022)1.76092051
89Hypoplasia of the thymus (HP:0000778)1.75366728
90Skin rash (HP:0000988)1.75124029
91Thyroiditis (HP:0100646)1.73352908
92Symptomatic seizures (HP:0011145)1.70856563
93Chest pain (HP:0100749)1.70216786
94Abnormality of male internal genitalia (HP:0000022)1.69090769
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.68847495
96Menstrual irregularities (HP:0000858)1.68233914
97Severe combined immunodeficiency (HP:0004430)1.65984957
98Recurrent corneal erosions (HP:0000495)1.65754658
99Abnormality of the pleura (HP:0002103)1.64736659
100Polyuria (HP:0000103)1.64416055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.22124823
2MAP4K14.81355020
3ERN14.02688546
4RIPK43.71849904
5MAP3K103.63462097
6CSF1R2.91581335
7FRK2.66093494
8SYK2.45031980
9KIT2.35871215
10PRKG22.28589025
11FLT32.25696513
12IKBKE2.21687581
13NEK92.12197810
14BTK2.09387998
15SCYL21.93297900
16EIF2AK31.92269792
17STK161.75143441
18MAP3K141.66558527
19TEC1.64821267
20ITK1.62211840
21TNK21.61544087
22LYN1.54115040
23IRAK41.49128664
24MST41.32248787
25PLK41.30228676
26PRKCQ1.23206315
27PIK3CG1.21986802
28CDK41.21014486
29PRPF4B1.15443056
30NUAK11.10626315
31STK241.08866893
32HCK1.08624199
33CCNB11.07925182
34FES1.07702787
35TLK11.02596346
36PASK0.99973149
37TBK10.98669545
38CSK0.95398103
39TAOK30.91195145
40MAPK110.91004019
41ACVR1B0.90710121
42BMPR1B0.90700092
43IKBKB0.90203734
44SIK20.85169633
45LCK0.84344912
46JAK30.83635025
47JAK10.80025496
48TYK20.76100012
49MAP3K130.75123651
50SIK30.71652234
51AKT30.69595606
52MAP3K10.68059467
53GRK60.65127360
54MAP2K30.62208126
55TAOK10.62127135
56ZAP700.60917017
57CDK90.59739958
58PDK10.59555701
59BMPR20.59443721
60PKN10.56881925
61PIM10.51707238
62ATR0.51018600
63GRK10.50862428
64BCKDK0.50302009
65CDC70.50090561
66SGK20.49059401
67MAP3K70.48812220
68ZAK0.46026593
69MAPK70.43668706
70SMG10.42254777
71MARK30.40390716
72STK30.40162577
73STK40.38785562
74FYN0.38569212
75VRK10.38398999
76EEF2K0.37380439
77TXK0.37180740
78RAF10.37166212
79ABL10.37130198
80FGFR30.37053250
81PRKD20.36902779
82MKNK20.34731979
83MAP3K80.34253499
84CDK120.34128898
85RPS6KB20.33054348
86ALK0.31796109
87PRKCH0.31397968
88JAK20.30932543
89RPS6KA40.30650574
90CDK70.30578213
91SGK30.29578759
92ADRBK20.29108879
93MATK0.28327156
94TESK20.28224412
95HIPK20.27794829
96CDC42BPA0.27511472
97TAOK20.27293392
98RPS6KB10.26990289
99BRAF0.26745187
100NEK20.26284439

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.92284399
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.08385802
3Allograft rejection_Homo sapiens_hsa053303.73098327
4B cell receptor signaling pathway_Homo sapiens_hsa046623.69849462
5Autoimmune thyroid disease_Homo sapiens_hsa053203.43843475
6Graft-versus-host disease_Homo sapiens_hsa053323.38056470
7Type I diabetes mellitus_Homo sapiens_hsa049403.10676179
8Asthma_Homo sapiens_hsa053102.83328043
9Antigen processing and presentation_Homo sapiens_hsa046122.44939479
10Vitamin B6 metabolism_Homo sapiens_hsa007502.16277484
11Leishmaniasis_Homo sapiens_hsa051402.09475801
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07141178
13Herpes simplex infection_Homo sapiens_hsa051681.94286812
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.92064110
15Staphylococcus aureus infection_Homo sapiens_hsa051501.83887283
16Hematopoietic cell lineage_Homo sapiens_hsa046401.75444669
17Viral myocarditis_Homo sapiens_hsa054161.75202772
18Measles_Homo sapiens_hsa051621.72608610
19One carbon pool by folate_Homo sapiens_hsa006701.71520547
20Systemic lupus erythematosus_Homo sapiens_hsa053221.67178106
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60286752
22Influenza A_Homo sapiens_hsa051641.51651207
23Base excision repair_Homo sapiens_hsa034101.48806892
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42512939
25Homologous recombination_Homo sapiens_hsa034401.29341912
26Platelet activation_Homo sapiens_hsa046111.28250782
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25208682
28Toxoplasmosis_Homo sapiens_hsa051451.24712358
29Osteoclast differentiation_Homo sapiens_hsa043801.24316308
30Tuberculosis_Homo sapiens_hsa051521.24065617
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22446173
32Butanoate metabolism_Homo sapiens_hsa006501.11831817
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10791687
34Epstein-Barr virus infection_Homo sapiens_hsa051691.09144930
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98771373
36T cell receptor signaling pathway_Homo sapiens_hsa046600.96213955
37Linoleic acid metabolism_Homo sapiens_hsa005910.95371912
38Olfactory transduction_Homo sapiens_hsa047400.92733858
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92611981
40Mismatch repair_Homo sapiens_hsa034300.92384195
41Hepatitis B_Homo sapiens_hsa051610.92287727
42Chemokine signaling pathway_Homo sapiens_hsa040620.91140925
43African trypanosomiasis_Homo sapiens_hsa051430.91030353
44Viral carcinogenesis_Homo sapiens_hsa052030.89492671
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80912860
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74062479
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72152673
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.68572481
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67434692
50Alcoholism_Homo sapiens_hsa050340.67330786
51Non-small cell lung cancer_Homo sapiens_hsa052230.66199131
52HTLV-I infection_Homo sapiens_hsa051660.65959459
53Non-homologous end-joining_Homo sapiens_hsa034500.62532990
54DNA replication_Homo sapiens_hsa030300.62471082
55Long-term depression_Homo sapiens_hsa047300.62076538
56Acute myeloid leukemia_Homo sapiens_hsa052210.59826152
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56960845
58Hepatitis C_Homo sapiens_hsa051600.55892293
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54394804
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.53865068
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52830535
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51877170
63Dorso-ventral axis formation_Homo sapiens_hsa043200.51153944
64Apoptosis_Homo sapiens_hsa042100.50514731
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50460365
66Rheumatoid arthritis_Homo sapiens_hsa053230.49196827
67Inositol phosphate metabolism_Homo sapiens_hsa005620.48224120
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.47183206
69TNF signaling pathway_Homo sapiens_hsa046680.44547803
70Chronic myeloid leukemia_Homo sapiens_hsa052200.42056398
71Fanconi anemia pathway_Homo sapiens_hsa034600.41632514
72MAPK signaling pathway_Homo sapiens_hsa040100.41598917
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38600983
74RNA degradation_Homo sapiens_hsa030180.36049809
75Nucleotide excision repair_Homo sapiens_hsa034200.35330682
76Legionellosis_Homo sapiens_hsa051340.35310282
77ABC transporters_Homo sapiens_hsa020100.34774905
78Malaria_Homo sapiens_hsa051440.34455116
79Phototransduction_Homo sapiens_hsa047440.32816283
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27247437
81Shigellosis_Homo sapiens_hsa051310.27089321
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.25935140
83Caffeine metabolism_Homo sapiens_hsa002320.25725584
84mTOR signaling pathway_Homo sapiens_hsa041500.24377963
85Type II diabetes mellitus_Homo sapiens_hsa049300.24111174
86Pancreatic secretion_Homo sapiens_hsa049720.23679299
87Renin secretion_Homo sapiens_hsa049240.23669059
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23062448
89Notch signaling pathway_Homo sapiens_hsa043300.22036954
90Small cell lung cancer_Homo sapiens_hsa052220.21740949
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20986886
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.19050062
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.18519169
94Serotonergic synapse_Homo sapiens_hsa047260.18232065
95Purine metabolism_Homo sapiens_hsa002300.17735294
96Cell cycle_Homo sapiens_hsa041100.16736487
97Salivary secretion_Homo sapiens_hsa049700.16136183
98Long-term potentiation_Homo sapiens_hsa047200.15321479
99Fatty acid degradation_Homo sapiens_hsa000710.14789437
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.14609858

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