Rank | Gene Set | Z-score |
---|---|---|
1 | regulation of B cell receptor signaling pathway (GO:0050855) | 7.00745618 |
2 | B cell receptor signaling pathway (GO:0050853) | 6.96627027 |
3 | NIK/NF-kappaB signaling (GO:0038061) | 5.64329119 |
4 | regulation of B cell differentiation (GO:0045577) | 5.12113498 |
5 | positive regulation of vascular permeability (GO:0043117) | 5.10628180 |
6 | drinking behavior (GO:0042756) | 5.06961901 |
7 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.91643423 |
8 | positive regulation of B cell differentiation (GO:0045579) | 4.90989328 |
9 | negative regulation of necrotic cell death (GO:0060547) | 4.64761363 |
10 | B cell proliferation (GO:0042100) | 4.58176392 |
11 | snRNA transcription (GO:0009301) | 4.57232801 |
12 | mannose metabolic process (GO:0006013) | 4.38762373 |
13 | germinal center formation (GO:0002467) | 4.30461955 |
14 | immunoglobulin mediated immune response (GO:0016064) | 4.22455449 |
15 | peptide catabolic process (GO:0043171) | 4.12646779 |
16 | positive regulation of Rap GTPase activity (GO:0032854) | 4.04791043 |
17 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.96777764 |
18 | negative regulation of cell size (GO:0045792) | 3.96467953 |
19 | I-kappaB phosphorylation (GO:0007252) | 3.93928471 |
20 | determination of adult lifespan (GO:0008340) | 3.85445767 |
21 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.84532402 |
22 | nerve growth factor signaling pathway (GO:0038180) | 3.74406611 |
23 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.69696722 |
24 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.69445471 |
25 | negative regulation of response to food (GO:0032096) | 3.68944276 |
26 | negative regulation of appetite (GO:0032099) | 3.68944276 |
27 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.68415337 |
28 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.68415337 |
29 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.68332420 |
30 | T cell migration (GO:0072678) | 3.63000804 |
31 | Rap protein signal transduction (GO:0032486) | 3.59354040 |
32 | mature B cell differentiation (GO:0002335) | 3.58472893 |
33 | negative regulation of phagocytosis (GO:0050765) | 3.57844783 |
34 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.57604494 |
35 | regulation of gamma-delta T cell activation (GO:0046643) | 3.53029809 |
36 | negative regulation of digestive system process (GO:0060457) | 3.52557002 |
37 | positive regulation of granulocyte differentiation (GO:0030854) | 3.50622236 |
38 | B cell homeostasis (GO:0001782) | 3.47727434 |
39 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.45525853 |
40 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.42315135 |
41 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.41971252 |
42 | B cell mediated immunity (GO:0019724) | 3.41253264 |
43 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.40405929 |
44 | regulation of Rap GTPase activity (GO:0032317) | 3.38603995 |
45 | regulation of appetite (GO:0032098) | 3.33086665 |
46 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.32981069 |
47 | negative regulation of cell killing (GO:0031342) | 3.32981069 |
48 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.32114957 |
49 | response to type I interferon (GO:0034340) | 3.31579996 |
50 | cellular response to type I interferon (GO:0071357) | 3.30829990 |
51 | type I interferon signaling pathway (GO:0060337) | 3.30829990 |
52 | positive regulation of protein oligomerization (GO:0032461) | 3.26857133 |
53 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.26021513 |
54 | positive regulation of interferon-alpha production (GO:0032727) | 3.22606233 |
55 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.20621048 |
56 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.18482935 |
57 | negative regulation of alpha-beta T cell activation (GO:0046636) | 3.16993630 |
58 | regulation of germinal center formation (GO:0002634) | 3.14814990 |
59 | cytidine deamination (GO:0009972) | 3.14456844 |
60 | cytidine metabolic process (GO:0046087) | 3.14456844 |
61 | cytidine catabolic process (GO:0006216) | 3.14456844 |
62 | response to nerve growth factor (GO:1990089) | 3.13477417 |
63 | cellular response to nerve growth factor stimulus (GO:1990090) | 3.13477417 |
64 | B cell activation (GO:0042113) | 3.11482998 |
65 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.10703674 |
66 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.09440193 |
67 | regulation of B cell proliferation (GO:0030888) | 3.07698620 |
68 | hormone catabolic process (GO:0042447) | 3.07672789 |
69 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.07475059 |
70 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.06654731 |
71 | defense response to protozoan (GO:0042832) | 3.06636438 |
72 | positive regulation of B cell activation (GO:0050871) | 3.06077389 |
73 | regulation of response to food (GO:0032095) | 3.04938109 |
74 | regulation of necrotic cell death (GO:0010939) | 3.04481591 |
75 | positive thymic T cell selection (GO:0045059) | 3.04148314 |
76 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.03327817 |
77 | Peyers patch development (GO:0048541) | 3.03327817 |
78 | negative regulation of bone resorption (GO:0045779) | 3.00906275 |
79 | regulation of interferon-alpha production (GO:0032647) | 2.97166971 |
80 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.94825961 |
81 | positive regulation of B cell proliferation (GO:0030890) | 2.93310761 |
82 | mononuclear cell proliferation (GO:0032943) | 2.90587699 |
83 | lymphocyte proliferation (GO:0046651) | 2.89909010 |
84 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.87253037 |
85 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.85795448 |
86 | regulation of B cell activation (GO:0050864) | 2.82149614 |
87 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.82141410 |
88 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.82141410 |
89 | modulation by symbiont of host immune response (GO:0052553) | 2.82141410 |
90 | positive regulation by symbiont of host defense response (GO:0052509) | 2.82141410 |
91 | modulation by symbiont of host defense response (GO:0052031) | 2.82141410 |
92 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.82141410 |
93 | hepatocyte apoptotic process (GO:0097284) | 2.80310529 |
94 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.79560742 |
95 | T cell lineage commitment (GO:0002360) | 2.77531368 |
96 | leukocyte proliferation (GO:0070661) | 2.76457817 |
97 | T cell selection (GO:0045058) | 2.73084319 |
98 | positive regulation of protein deacetylation (GO:0090312) | 2.70336595 |
99 | positive T cell selection (GO:0043368) | 2.68207975 |
100 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.67948259 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.29547611 |
2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.94005766 |
3 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.81779005 |
4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.31685281 |
5 | MYC_22102868_ChIP-Seq_BL_Human | 4.24003789 |
6 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 3.49153262 |
7 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.37649043 |
8 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.25581912 |
9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.10991416 |
10 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.91616607 |
11 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.83191822 |
12 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.74346306 |
13 | MYB_26560356_Chip-Seq_TH2_Human | 2.70890529 |
14 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.59517001 |
15 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.31293322 |
16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.31156800 |
17 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.22351658 |
18 | MYB_26560356_Chip-Seq_TH1_Human | 2.22211842 |
19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.17810788 |
20 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.12174388 |
21 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.07937045 |
22 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.98077877 |
23 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.89435787 |
24 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.88813215 |
25 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.87287441 |
26 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.86549029 |
27 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.85725823 |
28 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.79645701 |
29 | GATA3_26560356_Chip-Seq_TH2_Human | 1.73619429 |
30 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.73299619 |
31 | SPI1_23127762_ChIP-Seq_K562_Human | 1.68867712 |
32 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.64381794 |
33 | MAF_26560356_Chip-Seq_TH1_Human | 1.62367975 |
34 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61683315 |
35 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.60883837 |
36 | UTX_26944678_Chip-Seq_JUKART_Human | 1.59494377 |
37 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.58843488 |
38 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.56899822 |
39 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.50141811 |
40 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49323834 |
41 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.47350162 |
42 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.45667722 |
43 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.41467401 |
44 | GATA1_22025678_ChIP-Seq_K562_Human | 1.39754942 |
45 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38693512 |
46 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.37029951 |
47 | MAF_26560356_Chip-Seq_TH2_Human | 1.34466997 |
48 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.33852447 |
49 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.31513172 |
50 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.29913581 |
51 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.25551616 |
52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19806171 |
53 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.19410554 |
54 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.18312312 |
55 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17644639 |
56 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.16640539 |
57 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.14365982 |
58 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.14221485 |
59 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.11750739 |
60 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.11140707 |
61 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.10632356 |
62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08074133 |
63 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.07113949 |
64 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.02688192 |
65 | GATA3_26560356_Chip-Seq_TH1_Human | 1.02096055 |
66 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.98572499 |
67 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.97740866 |
68 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97081502 |
69 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.90889037 |
70 | P300_27268052_Chip-Seq_Bcells_Human | 0.89500972 |
71 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89175433 |
72 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.87663304 |
73 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.86899649 |
74 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.86462304 |
75 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.85761927 |
76 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83790397 |
77 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.83447115 |
78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.82660025 |
79 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.82573530 |
80 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.80251949 |
81 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.79928603 |
82 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.78178442 |
83 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.77202882 |
84 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.74741824 |
85 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73534017 |
86 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.73501936 |
87 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.72624563 |
88 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.71881763 |
89 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.71855520 |
90 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71845485 |
91 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.71782840 |
92 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.71774419 |
93 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.70849525 |
94 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.70601457 |
95 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.70601457 |
96 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.69985891 |
97 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.69024001 |
98 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.68698206 |
99 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.68369678 |
100 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.68236208 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002396_abnormal_hematopoietic_system | 4.60759908 |
2 | MP0001835_abnormal_antigen_presentation | 4.12233650 |
3 | MP0001790_abnormal_immune_system | 4.11491878 |
4 | MP0005387_immune_system_phenotype | 4.11491878 |
5 | MP0001800_abnormal_humoral_immune | 3.89299890 |
6 | MP0005671_abnormal_response_to | 3.19353596 |
7 | MP0000685_abnormal_immune_system | 3.16138876 |
8 | MP0005000_abnormal_immune_tolerance | 3.01369711 |
9 | MP0003303_peritoneal_inflammation | 2.91563659 |
10 | MP0003763_abnormal_thymus_physiology | 2.88942963 |
11 | MP0002452_abnormal_antigen_presenting | 2.85804131 |
12 | MP0002723_abnormal_immune_serum | 2.76258508 |
13 | MP0002420_abnormal_adaptive_immunity | 2.59341289 |
14 | MP0001819_abnormal_immune_cell | 2.49072399 |
15 | MP0005310_abnormal_salivary_gland | 2.42412611 |
16 | MP0002398_abnormal_bone_marrow | 2.41935300 |
17 | MP0001986_abnormal_taste_sensitivity | 2.33549704 |
18 | MP0009785_altered_susceptibility_to | 2.24678453 |
19 | MP0002405_respiratory_system_inflammati | 2.20559375 |
20 | MP0000689_abnormal_spleen_morphology | 2.20483063 |
21 | MP0005025_abnormal_response_to | 2.18784552 |
22 | MP0000716_abnormal_immune_system | 2.15670704 |
23 | MP0008057_abnormal_DNA_replication | 2.13354548 |
24 | MP0002166_altered_tumor_susceptibility | 1.88133055 |
25 | MP0002722_abnormal_immune_system | 1.86224255 |
26 | MP0003436_decreased_susceptibility_to | 1.84570815 |
27 | MP0000013_abnormal_adipose_tissue | 1.83568374 |
28 | MP0002429_abnormal_blood_cell | 1.71771433 |
29 | MP0002419_abnormal_innate_immunity | 1.70554859 |
30 | MP0002138_abnormal_hepatobiliary_system | 1.68072439 |
31 | MP0001845_abnormal_inflammatory_respons | 1.54308554 |
32 | MP0000703_abnormal_thymus_morphology | 1.53965859 |
33 | MP0010094_abnormal_chromosome_stability | 1.53068197 |
34 | MP0002928_abnormal_bile_duct | 1.52838877 |
35 | MP0010155_abnormal_intestine_physiology | 1.49070394 |
36 | MP0003300_gastrointestinal_ulcer | 1.47911801 |
37 | MP0009333_abnormal_splenocyte_physiolog | 1.46572521 |
38 | MP0005464_abnormal_platelet_physiology | 1.45154896 |
39 | MP0002653_abnormal_ependyma_morphology | 1.40255729 |
40 | MP0001873_stomach_inflammation | 1.37761129 |
41 | MP0002148_abnormal_hypersensitivity_rea | 1.31826589 |
42 | MP0002009_preneoplasia | 1.26675800 |
43 | MP0005645_abnormal_hypothalamus_physiol | 1.26250184 |
44 | MP0000678_abnormal_parathyroid_gland | 1.24502926 |
45 | MP0005075_abnormal_melanosome_morpholog | 1.21915674 |
46 | MP0002006_tumorigenesis | 1.14276317 |
47 | MP0004808_abnormal_hematopoietic_stem | 1.13445397 |
48 | MP0002132_abnormal_respiratory_system | 1.10520141 |
49 | MP0003866_abnormal_defecation | 1.08688952 |
50 | MP0004381_abnormal_hair_follicle | 1.07273406 |
51 | MP0000015_abnormal_ear_pigmentation | 1.06751731 |
52 | MP0003252_abnormal_bile_duct | 1.05431809 |
53 | MP0000371_diluted_coat_color | 1.04745496 |
54 | MP0008469_abnormal_protein_level | 1.00977405 |
55 | MP0002822_catalepsy | 0.97411294 |
56 | MP0003724_increased_susceptibility_to | 0.96952748 |
57 | MP0005084_abnormal_gallbladder_morpholo | 0.96524885 |
58 | MP0004947_skin_inflammation | 0.94677994 |
59 | MP0002019_abnormal_tumor_incidence | 0.93069731 |
60 | MP0010386_abnormal_urinary_bladder | 0.90184713 |
61 | MP0002136_abnormal_kidney_physiology | 0.88780195 |
62 | MP0000003_abnormal_adipose_tissue | 0.87760414 |
63 | MP0001348_abnormal_lacrimal_gland | 0.86071645 |
64 | MP0002693_abnormal_pancreas_physiology | 0.82084835 |
65 | MP0005379_endocrine/exocrine_gland_phen | 0.81755966 |
66 | MP0003045_fibrosis | 0.80565237 |
67 | MP0003656_abnormal_erythrocyte_physiolo | 0.79929116 |
68 | MP0009764_decreased_sensitivity_to | 0.77680320 |
69 | MP0003077_abnormal_cell_cycle | 0.77659246 |
70 | MP0005410_abnormal_fertilization | 0.75152103 |
71 | MP0002735_abnormal_chemical_nociception | 0.73483683 |
72 | MP0001968_abnormal_touch/_nociception | 0.73234404 |
73 | MP0000372_irregular_coat_pigmentation | 0.73075389 |
74 | MP0002127_abnormal_cardiovascular_syste | 0.72265141 |
75 | MP0003111_abnormal_nucleus_morphology | 0.72254926 |
76 | MP0001853_heart_inflammation | 0.68827995 |
77 | MP0003183_abnormal_peptide_metabolism | 0.68626534 |
78 | MP0008872_abnormal_physiological_respon | 0.66983309 |
79 | MP0009115_abnormal_fat_cell | 0.66675548 |
80 | MP0008874_decreased_physiological_sensi | 0.65268696 |
81 | MP0006072_abnormal_retinal_apoptosis | 0.63683681 |
82 | MP0003787_abnormal_imprinting | 0.62031649 |
83 | MP0000313_abnormal_cell_death | 0.61940070 |
84 | MP0002095_abnormal_skin_pigmentation | 0.58836839 |
85 | MP0005551_abnormal_eye_electrophysiolog | 0.58761815 |
86 | MP0000465_gastrointestinal_hemorrhage | 0.58748677 |
87 | MP0000604_amyloidosis | 0.57859214 |
88 | MP0006036_abnormal_mitochondrial_physio | 0.57779939 |
89 | MP0000569_abnormal_digit_pigmentation | 0.56676290 |
90 | MP0009643_abnormal_urine_homeostasis | 0.56535755 |
91 | MP0002163_abnormal_gland_morphology | 0.56436935 |
92 | MP0008058_abnormal_DNA_repair | 0.54636351 |
93 | MP0000609_abnormal_liver_physiology | 0.54146140 |
94 | MP0003693_abnormal_embryo_hatching | 0.53967899 |
95 | MP0008877_abnormal_DNA_methylation | 0.51790070 |
96 | MP0005166_decreased_susceptibility_to | 0.50375902 |
97 | MP0005253_abnormal_eye_physiology | 0.49658983 |
98 | MP0005332_abnormal_amino_acid | 0.48156114 |
99 | MP0001663_abnormal_digestive_system | 0.45745342 |
100 | MP0001929_abnormal_gametogenesis | 0.45370157 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Agammaglobulinemia (HP:0004432) | 6.84152626 |
2 | Gastrointestinal stroma tumor (HP:0100723) | 6.80419212 |
3 | Panhypogammaglobulinemia (HP:0003139) | 5.31223928 |
4 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 5.28049622 |
5 | Lymphopenia (HP:0001888) | 4.68692657 |
6 | Recurrent sinusitis (HP:0011108) | 4.47216306 |
7 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 4.33769343 |
8 | Meningitis (HP:0001287) | 4.32519808 |
9 | Vasculitis (HP:0002633) | 4.19137226 |
10 | Colitis (HP:0002583) | 4.04528046 |
11 | Generalized aminoaciduria (HP:0002909) | 4.02765104 |
12 | Recurrent bronchitis (HP:0002837) | 3.85553633 |
13 | Abnormality of the costochondral junction (HP:0000919) | 3.82654730 |
14 | Recurrent cutaneous fungal infections (HP:0011370) | 3.80272516 |
15 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.80272516 |
16 | Recurrent viral infections (HP:0004429) | 3.76068364 |
17 | Emphysema (HP:0002097) | 3.58837018 |
18 | Inflammation of the large intestine (HP:0002037) | 3.48781717 |
19 | Cellulitis (HP:0100658) | 3.45555837 |
20 | Lymphoma (HP:0002665) | 3.34914543 |
21 | Gastrointestinal inflammation (HP:0004386) | 3.34661135 |
22 | Verrucae (HP:0200043) | 3.24078102 |
23 | Papilloma (HP:0012740) | 3.24078102 |
24 | Abnormality of T cell physiology (HP:0011840) | 3.22242231 |
25 | Male infertility (HP:0003251) | 3.21580678 |
26 | IgM deficiency (HP:0002850) | 3.20532437 |
27 | Recurrent lower respiratory tract infections (HP:0002783) | 3.18047908 |
28 | Failure to thrive in infancy (HP:0001531) | 3.17840453 |
29 | Encephalitis (HP:0002383) | 3.14510923 |
30 | Hypophosphatemic rickets (HP:0004912) | 3.13203878 |
31 | Mediastinal lymphadenopathy (HP:0100721) | 3.09561057 |
32 | Osteomyelitis (HP:0002754) | 3.09328314 |
33 | Recurrent pneumonia (HP:0006532) | 3.07506266 |
34 | Recurrent fungal infections (HP:0002841) | 3.02015799 |
35 | Chronic sinusitis (HP:0011109) | 2.92497345 |
36 | Abnormality of T cells (HP:0002843) | 2.87957314 |
37 | Hypoglycemic seizures (HP:0002173) | 2.87772480 |
38 | Abnormality of B cell number (HP:0010975) | 2.80211567 |
39 | IgA deficiency (HP:0002720) | 2.77963769 |
40 | Viral hepatitis (HP:0006562) | 2.75941822 |
41 | Tetany (HP:0001281) | 2.74194739 |
42 | Leukopenia (HP:0001882) | 2.71886221 |
43 | Chronic otitis media (HP:0000389) | 2.71048322 |
44 | Acute hepatic failure (HP:0006554) | 2.67254848 |
45 | Recurrent skin infections (HP:0001581) | 2.66216459 |
46 | Restrictive lung disease (HP:0002091) | 2.65758109 |
47 | Increased IgM level (HP:0003496) | 2.60517780 |
48 | Abnormality of the prostate (HP:0008775) | 2.54431402 |
49 | Recurrent bacterial skin infections (HP:0005406) | 2.54366436 |
50 | B lymphocytopenia (HP:0010976) | 2.49245719 |
51 | Villous atrophy (HP:0011473) | 2.45375949 |
52 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.45375949 |
53 | Exocrine pancreatic insufficiency (HP:0001738) | 2.43035995 |
54 | Abnormal drinking behavior (HP:0030082) | 2.40223253 |
55 | Polydipsia (HP:0001959) | 2.40223253 |
56 | Delayed puberty (HP:0000823) | 2.37783458 |
57 | Renal Fanconi syndrome (HP:0001994) | 2.37704102 |
58 | Recurrent abscess formation (HP:0002722) | 2.33771898 |
59 | IgG deficiency (HP:0004315) | 2.33129991 |
60 | Sepsis (HP:0100806) | 2.31110073 |
61 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.30610597 |
62 | Recurrent otitis media (HP:0000403) | 2.29075887 |
63 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.26876827 |
64 | Abnormality of macrophages (HP:0004311) | 2.25450085 |
65 | Eczematoid dermatitis (HP:0000976) | 2.18307145 |
66 | Neutropenia (HP:0001875) | 2.17002953 |
67 | Abnormality of T cell number (HP:0011839) | 2.16034134 |
68 | Prostate neoplasm (HP:0100787) | 2.12646716 |
69 | Bronchitis (HP:0012387) | 2.11475652 |
70 | Congenital primary aphakia (HP:0007707) | 2.10118889 |
71 | T lymphocytopenia (HP:0005403) | 2.09916945 |
72 | Chronic diarrhea (HP:0002028) | 2.04293611 |
73 | Gait imbalance (HP:0002141) | 2.04054937 |
74 | Acute lymphatic leukemia (HP:0006721) | 2.02166519 |
75 | Obstructive lung disease (HP:0006536) | 1.97126745 |
76 | Chronic obstructive pulmonary disease (HP:0006510) | 1.97126745 |
77 | Carpal bone hypoplasia (HP:0001498) | 1.97028236 |
78 | Pulmonary infiltrates (HP:0002113) | 1.96971313 |
79 | Medial flaring of the eyebrow (HP:0010747) | 1.93585452 |
80 | Gastrointestinal infarctions (HP:0005244) | 1.92686104 |
81 | Type I diabetes mellitus (HP:0100651) | 1.90401874 |
82 | Spontaneous hematomas (HP:0007420) | 1.88459812 |
83 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.88386469 |
84 | Urticaria (HP:0001025) | 1.85920292 |
85 | Nephrogenic diabetes insipidus (HP:0009806) | 1.84778650 |
86 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.81833306 |
87 | Basal cell carcinoma (HP:0002671) | 1.78941506 |
88 | Albinism (HP:0001022) | 1.76092051 |
89 | Hypoplasia of the thymus (HP:0000778) | 1.75366728 |
90 | Skin rash (HP:0000988) | 1.75124029 |
91 | Thyroiditis (HP:0100646) | 1.73352908 |
92 | Symptomatic seizures (HP:0011145) | 1.70856563 |
93 | Chest pain (HP:0100749) | 1.70216786 |
94 | Abnormality of male internal genitalia (HP:0000022) | 1.69090769 |
95 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.68847495 |
96 | Menstrual irregularities (HP:0000858) | 1.68233914 |
97 | Severe combined immunodeficiency (HP:0004430) | 1.65984957 |
98 | Recurrent corneal erosions (HP:0000495) | 1.65754658 |
99 | Abnormality of the pleura (HP:0002103) | 1.64736659 |
100 | Polyuria (HP:0000103) | 1.64416055 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BLK | 5.22124823 |
2 | MAP4K1 | 4.81355020 |
3 | ERN1 | 4.02688546 |
4 | RIPK4 | 3.71849904 |
5 | MAP3K10 | 3.63462097 |
6 | CSF1R | 2.91581335 |
7 | FRK | 2.66093494 |
8 | SYK | 2.45031980 |
9 | KIT | 2.35871215 |
10 | PRKG2 | 2.28589025 |
11 | FLT3 | 2.25696513 |
12 | IKBKE | 2.21687581 |
13 | NEK9 | 2.12197810 |
14 | BTK | 2.09387998 |
15 | SCYL2 | 1.93297900 |
16 | EIF2AK3 | 1.92269792 |
17 | STK16 | 1.75143441 |
18 | MAP3K14 | 1.66558527 |
19 | TEC | 1.64821267 |
20 | ITK | 1.62211840 |
21 | TNK2 | 1.61544087 |
22 | LYN | 1.54115040 |
23 | IRAK4 | 1.49128664 |
24 | MST4 | 1.32248787 |
25 | PLK4 | 1.30228676 |
26 | PRKCQ | 1.23206315 |
27 | PIK3CG | 1.21986802 |
28 | CDK4 | 1.21014486 |
29 | PRPF4B | 1.15443056 |
30 | NUAK1 | 1.10626315 |
31 | STK24 | 1.08866893 |
32 | HCK | 1.08624199 |
33 | CCNB1 | 1.07925182 |
34 | FES | 1.07702787 |
35 | TLK1 | 1.02596346 |
36 | PASK | 0.99973149 |
37 | TBK1 | 0.98669545 |
38 | CSK | 0.95398103 |
39 | TAOK3 | 0.91195145 |
40 | MAPK11 | 0.91004019 |
41 | ACVR1B | 0.90710121 |
42 | BMPR1B | 0.90700092 |
43 | IKBKB | 0.90203734 |
44 | SIK2 | 0.85169633 |
45 | LCK | 0.84344912 |
46 | JAK3 | 0.83635025 |
47 | JAK1 | 0.80025496 |
48 | TYK2 | 0.76100012 |
49 | MAP3K13 | 0.75123651 |
50 | SIK3 | 0.71652234 |
51 | AKT3 | 0.69595606 |
52 | MAP3K1 | 0.68059467 |
53 | GRK6 | 0.65127360 |
54 | MAP2K3 | 0.62208126 |
55 | TAOK1 | 0.62127135 |
56 | ZAP70 | 0.60917017 |
57 | CDK9 | 0.59739958 |
58 | PDK1 | 0.59555701 |
59 | BMPR2 | 0.59443721 |
60 | PKN1 | 0.56881925 |
61 | PIM1 | 0.51707238 |
62 | ATR | 0.51018600 |
63 | GRK1 | 0.50862428 |
64 | BCKDK | 0.50302009 |
65 | CDC7 | 0.50090561 |
66 | SGK2 | 0.49059401 |
67 | MAP3K7 | 0.48812220 |
68 | ZAK | 0.46026593 |
69 | MAPK7 | 0.43668706 |
70 | SMG1 | 0.42254777 |
71 | MARK3 | 0.40390716 |
72 | STK3 | 0.40162577 |
73 | STK4 | 0.38785562 |
74 | FYN | 0.38569212 |
75 | VRK1 | 0.38398999 |
76 | EEF2K | 0.37380439 |
77 | TXK | 0.37180740 |
78 | RAF1 | 0.37166212 |
79 | ABL1 | 0.37130198 |
80 | FGFR3 | 0.37053250 |
81 | PRKD2 | 0.36902779 |
82 | MKNK2 | 0.34731979 |
83 | MAP3K8 | 0.34253499 |
84 | CDK12 | 0.34128898 |
85 | RPS6KB2 | 0.33054348 |
86 | ALK | 0.31796109 |
87 | PRKCH | 0.31397968 |
88 | JAK2 | 0.30932543 |
89 | RPS6KA4 | 0.30650574 |
90 | CDK7 | 0.30578213 |
91 | SGK3 | 0.29578759 |
92 | ADRBK2 | 0.29108879 |
93 | MATK | 0.28327156 |
94 | TESK2 | 0.28224412 |
95 | HIPK2 | 0.27794829 |
96 | CDC42BPA | 0.27511472 |
97 | TAOK2 | 0.27293392 |
98 | RPS6KB1 | 0.26990289 |
99 | BRAF | 0.26745187 |
100 | NEK2 | 0.26284439 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.92284399 |
2 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 4.08385802 |
3 | Allograft rejection_Homo sapiens_hsa05330 | 3.73098327 |
4 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.69849462 |
5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.43843475 |
6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.38056470 |
7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.10676179 |
8 | Asthma_Homo sapiens_hsa05310 | 2.83328043 |
9 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.44939479 |
10 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.16277484 |
11 | Leishmaniasis_Homo sapiens_hsa05140 | 2.09475801 |
12 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.07141178 |
13 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.94286812 |
14 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.92064110 |
15 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.83887283 |
16 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.75444669 |
17 | Viral myocarditis_Homo sapiens_hsa05416 | 1.75202772 |
18 | Measles_Homo sapiens_hsa05162 | 1.72608610 |
19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.71520547 |
20 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.67178106 |
21 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.60286752 |
22 | Influenza A_Homo sapiens_hsa05164 | 1.51651207 |
23 | Base excision repair_Homo sapiens_hsa03410 | 1.48806892 |
24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.42512939 |
25 | Homologous recombination_Homo sapiens_hsa03440 | 1.29341912 |
26 | Platelet activation_Homo sapiens_hsa04611 | 1.28250782 |
27 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.25208682 |
28 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.24712358 |
29 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.24316308 |
30 | Tuberculosis_Homo sapiens_hsa05152 | 1.24065617 |
31 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.22446173 |
32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.11831817 |
33 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.10791687 |
34 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.09144930 |
35 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.98771373 |
36 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.96213955 |
37 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.95371912 |
38 | Olfactory transduction_Homo sapiens_hsa04740 | 0.92733858 |
39 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.92611981 |
40 | Mismatch repair_Homo sapiens_hsa03430 | 0.92384195 |
41 | Hepatitis B_Homo sapiens_hsa05161 | 0.92287727 |
42 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.91140925 |
43 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.91030353 |
44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.89492671 |
45 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.80912860 |
46 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.74062479 |
47 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.72152673 |
48 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.68572481 |
49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.67434692 |
50 | Alcoholism_Homo sapiens_hsa05034 | 0.67330786 |
51 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.66199131 |
52 | HTLV-I infection_Homo sapiens_hsa05166 | 0.65959459 |
53 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.62532990 |
54 | DNA replication_Homo sapiens_hsa03030 | 0.62471082 |
55 | Long-term depression_Homo sapiens_hsa04730 | 0.62076538 |
56 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.59826152 |
57 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.56960845 |
58 | Hepatitis C_Homo sapiens_hsa05160 | 0.55892293 |
59 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.54394804 |
60 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.53865068 |
61 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.52830535 |
62 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.51877170 |
63 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.51153944 |
64 | Apoptosis_Homo sapiens_hsa04210 | 0.50514731 |
65 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.50460365 |
66 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49196827 |
67 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.48224120 |
68 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.47183206 |
69 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.44547803 |
70 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.42056398 |
71 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.41632514 |
72 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.41598917 |
73 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.38600983 |
74 | RNA degradation_Homo sapiens_hsa03018 | 0.36049809 |
75 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.35330682 |
76 | Legionellosis_Homo sapiens_hsa05134 | 0.35310282 |
77 | ABC transporters_Homo sapiens_hsa02010 | 0.34774905 |
78 | Malaria_Homo sapiens_hsa05144 | 0.34455116 |
79 | Phototransduction_Homo sapiens_hsa04744 | 0.32816283 |
80 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.27247437 |
81 | Shigellosis_Homo sapiens_hsa05131 | 0.27089321 |
82 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.25935140 |
83 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.25725584 |
84 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.24377963 |
85 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.24111174 |
86 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.23679299 |
87 | Renin secretion_Homo sapiens_hsa04924 | 0.23669059 |
88 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.23062448 |
89 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.22036954 |
90 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.21740949 |
91 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.20986886 |
92 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.19050062 |
93 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.18519169 |
94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.18232065 |
95 | Purine metabolism_Homo sapiens_hsa00230 | 0.17735294 |
96 | Cell cycle_Homo sapiens_hsa04110 | 0.16736487 |
97 | Salivary secretion_Homo sapiens_hsa04970 | 0.16136183 |
98 | Long-term potentiation_Homo sapiens_hsa04720 | 0.15321479 |
99 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.14789437 |
100 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.14609858 |