PRAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transforming growth factor beta2 production (GO:0032909)8.85627874
2angiotensin maturation (GO:0002003)8.52820400
3positive regulation of hair cycle (GO:0042635)8.03072323
4positive regulation of hair follicle development (GO:0051798)8.03072323
5regulation of cardioblast differentiation (GO:0051890)7.96646194
6positive regulation of guanylate cyclase activity (GO:0031284)7.75561212
7epoxygenase P450 pathway (GO:0019373)7.71530142
8regulation of guanylate cyclase activity (GO:0031282)7.13539889
9pathway-restricted SMAD protein phosphorylation (GO:0060389)7.05147776
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.03846401
11positive regulation of respiratory burst (GO:0060267)6.92464309
12gland morphogenesis (GO:0022612)6.72628086
13regulation of macrophage cytokine production (GO:0010935)6.43296855
14cardiac muscle cell proliferation (GO:0060038)6.26970435
15regulation of triglyceride catabolic process (GO:0010896)6.24427070
16positive regulation of T cell apoptotic process (GO:0070234)6.15998212
17regulation of alkaline phosphatase activity (GO:0010692)6.09860894
18NADH metabolic process (GO:0006734)6.08633418
19drug catabolic process (GO:0042737)6.02580783
20exogenous drug catabolic process (GO:0042738)5.98932494
21lipoprotein transport (GO:0042953)5.97152937
22drug metabolic process (GO:0017144)5.90585041
23very-low-density lipoprotein particle assembly (GO:0034379)5.80720177
24regulation of hair follicle development (GO:0051797)5.77000964
25urea metabolic process (GO:0019627)5.74902755
26cellular glucuronidation (GO:0052695)5.64089973
27regulation of bile acid biosynthetic process (GO:0070857)5.57451568
28cGMP biosynthetic process (GO:0006182)5.54047831
29positive regulation of odontogenesis (GO:0042482)5.52309408
30glucuronate metabolic process (GO:0019585)5.51819315
31uronic acid metabolic process (GO:0006063)5.51819315
32urea cycle (GO:0000050)5.48805669
33phospholipid efflux (GO:0033700)5.48008993
34glial cell migration (GO:0008347)5.45346531
35dopamine biosynthetic process (GO:0042416)5.36033269
36nitrogen cycle metabolic process (GO:0071941)5.28575958
37fructose metabolic process (GO:0006000)5.28200552
38plasma lipoprotein particle assembly (GO:0034377)5.24536923
39embryonic digestive tract development (GO:0048566)5.24107976
40striated muscle cell proliferation (GO:0014855)5.13888222
41regulation of cholesterol esterification (GO:0010872)5.06454321
42vitamin A metabolic process (GO:0006776)4.88341593
43generation of neurons (GO:0048699)4.86272498
44protein-lipid complex assembly (GO:0065005)4.73113895
45glucocorticoid biosynthetic process (GO:0006704)4.68980434
46regulation of apoptotic cell clearance (GO:2000425)4.68955457
47positive regulation of epidermis development (GO:0045684)4.64263031
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.64125756
49alkaloid metabolic process (GO:0009820)4.62579696
50high-density lipoprotein particle remodeling (GO:0034375)4.62124732
51positive regulation of triglyceride lipase activity (GO:0061365)4.59454185
52positive regulation of lipoprotein lipase activity (GO:0051006)4.59454185
53opsonization (GO:0008228)4.52990681
54fat-soluble vitamin biosynthetic process (GO:0042362)4.50253347
55bile acid metabolic process (GO:0008206)4.46789743
56positive regulation of cGMP biosynthetic process (GO:0030828)4.45912129
57positive regulation of lymphocyte apoptotic process (GO:0070230)4.45479382
58positive regulation of cell adhesion mediated by integrin (GO:0033630)4.44222990
59diacylglycerol metabolic process (GO:0046339)4.41426645
60negative regulation of cytokine production involved in immune response (GO:0002719)4.41141504
61negative regulation of complement activation (GO:0045916)4.40539208
62positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)4.40380670
63plasma lipoprotein particle remodeling (GO:0034369)4.36802346
64protein-lipid complex remodeling (GO:0034368)4.36802346
65macromolecular complex remodeling (GO:0034367)4.36802346
66ovulation from ovarian follicle (GO:0001542)4.35940009
67hormone catabolic process (GO:0042447)4.34641965
68citrulline biosynthetic process (GO:0019240)4.33697332
69omega-hydroxylase P450 pathway (GO:0097267)4.31955676
70positive regulation of macrophage differentiation (GO:0045651)4.26716415
71cardiac epithelial to mesenchymal transition (GO:0060317)4.26341161
72regulation of cGMP biosynthetic process (GO:0030826)4.26324047
73regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.24456350
74endocrine process (GO:0050886)4.24456350
75regulation of systemic arterial blood pressure by hormone (GO:0001990)4.24456350
76flavonoid metabolic process (GO:0009812)4.21501445
77muscle cell proliferation (GO:0033002)4.21024042
78somatic stem cell division (GO:0048103)4.17754861
79lipoprotein metabolic process (GO:0042157)4.17477758
80ethanol oxidation (GO:0006069)4.17044233
81positive regulation of macrophage derived foam cell differentiation (GO:0010744)4.16812358
82positive regulation of cGMP metabolic process (GO:0030825)4.14389008
83arginine metabolic process (GO:0006525)4.04426395
84cholesterol efflux (GO:0033344)4.02415408
85negative regulation of cholesterol transport (GO:0032375)4.02268648
86negative regulation of sterol transport (GO:0032372)4.02268648
87reverse cholesterol transport (GO:0043691)4.00126080
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94612752
89positive regulation of lipid catabolic process (GO:0050996)3.89603915
90plasma lipoprotein particle organization (GO:0071827)3.88980818
91regulation of monocyte differentiation (GO:0045655)3.86467279
92regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.82751822
93regulation of systemic arterial blood pressure (GO:0003073)3.78510527
94regulation of cGMP metabolic process (GO:0030823)3.74527873
95positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.74463507
96negative regulation of protein activation cascade (GO:2000258)3.74327772
97collagen fibril organization (GO:0030199)3.71611724
98vitamin biosynthetic process (GO:0009110)3.69867441
99protein-lipid complex subunit organization (GO:0071825)3.69147415
100adhesion of symbiont to host cell (GO:0044650)3.68148724
101virion attachment to host cell (GO:0019062)3.68148724
102regulation of hair cycle (GO:0042634)3.67318144
103decidualization (GO:0046697)3.66961438
104glutamine family amino acid biosynthetic process (GO:0009084)3.64962163
105phenylpropanoid metabolic process (GO:0009698)3.62667620
106branching involved in mammary gland duct morphogenesis (GO:0060444)3.61918512
107regulation of cellular extravasation (GO:0002691)3.61093179
108membrane repolarization during action potential (GO:0086011)3.61065076
109heme transport (GO:0015886)3.54043108
110detection of molecule of bacterial origin (GO:0032490)3.52879536
111cGMP metabolic process (GO:0046068)3.52847710
112negative regulation of production of molecular mediator of immune response (GO:0002701)3.50294360
113regulation of transforming growth factor beta production (GO:0071634)3.50274452
114drug transport (GO:0015893)3.50087313
115cholesterol homeostasis (GO:0042632)3.48630006
116peptide hormone processing (GO:0016486)3.47115538
117homocysteine metabolic process (GO:0050667)3.44184911
118drug transmembrane transport (GO:0006855)3.44068167
119sterol homeostasis (GO:0055092)3.42432919
120regulation of complement activation (GO:0030449)3.41694598
121cell aggregation (GO:0098743)3.41475046
122cartilage condensation (GO:0001502)3.41475046
123fucose catabolic process (GO:0019317)3.41284349
124L-fucose metabolic process (GO:0042354)3.41284349
125L-fucose catabolic process (GO:0042355)3.41284349
126fat-soluble vitamin metabolic process (GO:0006775)3.41063067
127regulation of hypersensitivity (GO:0002883)3.38014739
128complement activation, alternative pathway (GO:0006957)3.37903451
129vitamin transport (GO:0051180)3.35659271
130maintenance of gastrointestinal epithelium (GO:0030277)3.34128917
131digestion (GO:0007586)3.33374004
132positive regulation of fatty acid biosynthetic process (GO:0045723)3.32400283
133vitamin catabolic process (GO:0009111)3.31603461
134fat-soluble vitamin catabolic process (GO:0042363)3.31603461
135peptide catabolic process (GO:0043171)3.31184495
136adhesion of symbiont to host (GO:0044406)3.28861880
137regulation of respiratory burst (GO:0060263)3.28256983
138receptor guanylyl cyclase signaling pathway (GO:0007168)3.27609858
139interferon-gamma secretion (GO:0072643)3.26966302
140glycolipid catabolic process (GO:0019377)3.26019991
141ethanol metabolic process (GO:0006067)3.25544240
142L-ascorbic acid metabolic process (GO:0019852)3.24763453
143midgut development (GO:0007494)3.24685171
144glycosphingolipid catabolic process (GO:0046479)3.24206937
145response to hydroperoxide (GO:0033194)3.21506764
146negative regulation of fibrinolysis (GO:0051918)3.21322139
147oxidative demethylation (GO:0070989)3.20658660
148renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.17690392
149glyoxylate metabolic process (GO:0046487)3.17060487
150complement activation, classical pathway (GO:0006958)3.16874621
151antibacterial humoral response (GO:0019731)3.16761511
152apoptotic cell clearance (GO:0043277)3.16207020
153regulation of fibrinolysis (GO:0051917)3.15606562
154regulation of protein activation cascade (GO:2000257)3.14042259
155proline metabolic process (GO:0006560)3.13739558
156vitamin transmembrane transport (GO:0035461)3.13080565
157drinking behavior (GO:0042756)3.12550625
158acylglycerol homeostasis (GO:0055090)3.12391054
159triglyceride homeostasis (GO:0070328)3.12391054
160positive regulation of triglyceride metabolic process (GO:0090208)3.11666637
161low-density lipoprotein particle remodeling (GO:0034374)3.11215131
162macrophage differentiation (GO:0030225)3.10893602
163regulation of cholesterol homeostasis (GO:2000188)3.09837220
164lung lobe morphogenesis (GO:0060463)3.09494986
165catechol-containing compound biosynthetic process (GO:0009713)3.06649107
166catecholamine biosynthetic process (GO:0042423)3.06649107
167basement membrane organization (GO:0071711)3.05450698
168blood vessel remodeling (GO:0001974)3.03679375
169positive regulation of epithelial to mesenchymal transition (GO:0010718)3.01773525
170branching involved in salivary gland morphogenesis (GO:0060445)3.01750655
171renal system process involved in regulation of blood volume (GO:0001977)2.99383700
172glucocorticoid metabolic process (GO:0008211)2.97813977
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92799452
174protein heterotrimerization (GO:0070208)2.90050535
175fucose metabolic process (GO:0006004)2.89894594
176hemidesmosome assembly (GO:0031581)2.88819457
177positive regulation of heart contraction (GO:0045823)2.87757801
178regulation of macrophage derived foam cell differentiation (GO:0010743)2.84868277
179positive regulation of epidermal cell differentiation (GO:0045606)2.84107680
180negative regulation of humoral immune response (GO:0002921)2.82736527
181positive regulation of macrophage activation (GO:0043032)2.80845904
182bile acid and bile salt transport (GO:0015721)2.79689353
183potassium ion import (GO:0010107)2.78866244
184potassium ion export (GO:0071435)2.72565693
185regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.70443177
186cyclic purine nucleotide metabolic process (GO:0052652)2.69447022
187surfactant homeostasis (GO:0043129)2.68003517
188hydrogen peroxide catabolic process (GO:0042744)2.65104103
189intestinal absorption (GO:0050892)2.64639613
190excretion (GO:0007588)2.62931937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse3.92102699
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.78905757
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.45356813
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.30867090
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.09706434
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.00710071
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.97009549
8CLOCK_20551151_ChIP-Seq_293T_Human2.85132911
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80986094
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.74548417
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61184502
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.41232426
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27886470
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.27099384
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.24940218
16SOX2_20726797_ChIP-Seq_SW620_Human2.19849891
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.18151571
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.15795685
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.10687951
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99268790
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.99007426
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97357784
23GATA1_22025678_ChIP-Seq_K562_Human1.94627350
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94363996
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.94212111
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.92742024
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91863233
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90482189
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87277322
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85661880
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.84095233
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79883679
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.78903653
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.77529962
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76816301
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75207894
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74196799
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73013954
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72308384
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70680806
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.70045185
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68858958
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64694053
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61754777
45RACK7_27058665_Chip-Seq_MCF-7_Human1.58486842
46* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53526115
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53169040
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52097085
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.47825433
50* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44992028
51* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44992028
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36892925
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36608599
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36600288
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36026860
56LXR_22292898_ChIP-Seq_THP-1_Human1.35492142
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33995613
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.32797026
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.32548936
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32547472
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.32032306
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31274649
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29778230
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29536583
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28508695
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27490427
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26179217
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26179217
69TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24986812
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24081201
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23955330
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22971717
73SA1_27219007_Chip-Seq_Bcells_Human1.22965819
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21679668
75BCOR_27268052_Chip-Seq_Bcells_Human1.17978371
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17044313
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16938563
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16530301
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.15781972
80BCL6_27268052_Chip-Seq_Bcells_Human1.15580827
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14802774
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14802401
83CJUN_26792858_Chip-Seq_BT549_Human1.13644891
84CTCF_27219007_Chip-Seq_Bcells_Human1.13597484
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13458604
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11226940
87GATA4_25053715_ChIP-Seq_YYC3_Human1.11150132
88FOXA1_25552417_ChIP-Seq_VCAP_Human1.10262078
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09762111
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09577961
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08867988
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.07839882
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06352342
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.06177982
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06140652
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.05382796
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04863492
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04670531
99KLF5_25053715_ChIP-Seq_YYC3_Human1.04402344
100DROSHA_22980978_ChIP-Seq_HELA_Human1.04034269
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03992765
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03465937
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02606723
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02504810
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02452956
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02150268
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.02115861
108GATA6_25053715_ChIP-Seq_YYC3_Human1.01653111
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01482301
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01185569
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00770985
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00679004
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00200862
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98795291
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98699909
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98513292
117NANOG_20526341_ChIP-Seq_ESCs_Human0.97584718
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97166299
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96288939
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94807657
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94707838
122GATA1_19941826_ChIP-Seq_K562_Human0.94233984
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93468703
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93468703
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93307645
126CEBPB_22108803_ChIP-Seq_LS180_Human0.93262281
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.93014366
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.92977084
129GATA2_19941826_ChIP-Seq_K562_Human0.92884151
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92741247
131CDX2_22108803_ChIP-Seq_LS180_Human0.92619430
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91413364
133* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90467525
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89668066
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88891134
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87276944
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84676949
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84593484
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84522460
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82527736
141SOX2_21211035_ChIP-Seq_LN229_Human0.81317436
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80914385
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.79395671
144PHF8_20622854_ChIP-Seq_HELA_Human0.78825242
145SOX2_22085726_ChIP-Seq_NPCs_Mouse0.77080456
146EGR1_19032775_ChIP-ChIP_M12_Human0.76399079
147TAF2_19829295_ChIP-Seq_ESCs_Human0.75764934
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.75611487
149E2F1_20622854_ChIP-Seq_HELA_Human0.74501731
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74083688
151* CTCF_20526341_ChIP-Seq_ESCs_Human0.73740975
152P300_27268052_Chip-Seq_Bcells_Human0.73163131
153P53_21459846_ChIP-Seq_SAOS-2_Human0.72833156
154CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72448730
155SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72284565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage6.20757149
2MP0002254_reproductive_system_inflammat5.79622961
3MP0005365_abnormal_bile_salt4.70987234
4MP0008875_abnormal_xenobiotic_pharmacok4.65530013
5MP0008438_abnormal_cutaneous_collagen4.39085261
6MP0008004_abnormal_stomach_pH4.19431395
7MP0000681_abnormal_thyroid_gland3.57615078
8MP0003329_amyloid_beta_deposits3.38707383
9MP0010234_abnormal_vibrissa_follicle3.37259235
10MP0000604_amyloidosis3.36555804
11MP0003183_abnormal_peptide_metabolism3.34964667
12MP0001664_abnormal_digestion2.61669260
13MP0009379_abnormal_foot_pigmentation2.60501146
14MP0001765_abnormal_ion_homeostasis2.43623925
15MP0003868_abnormal_feces_composition2.43471999
16MP0004147_increased_porphyrin_level2.40094342
17MP0003252_abnormal_bile_duct2.39524971
18MP0005332_abnormal_amino_acid2.30997175
19MP0005167_abnormal_blood-brain_barrier2.25396535
20MP0005360_urolithiasis2.21833737
21MP0001666_abnormal_nutrient_absorption2.21065172
22MP0004272_abnormal_basement_membrane2.10453377
23MP0003566_abnormal_cell_adhesion2.01041665
24MP0004883_abnormal_blood_vessel1.93395913
25MP0002138_abnormal_hepatobiliary_system1.93236074
26MP0005275_abnormal_skin_tensile1.86295945
27MP0003806_abnormal_nucleotide_metabolis1.83094583
28MP0000462_abnormal_digestive_system1.80605978
29MP0005636_abnormal_mineral_homeostasis1.80234510
30MP0001881_abnormal_mammary_gland1.77512468
31MP0001958_emphysema1.75707109
32MP0001764_abnormal_homeostasis1.72409061
33MP0004019_abnormal_vitamin_homeostasis1.69220428
34MP0005409_darkened_coat_color1.66800298
35MP0004264_abnormal_extraembryonic_tissu1.63455388
36MP0001177_atelectasis1.51405152
37MP0002118_abnormal_lipid_homeostasis1.49984092
38MP0003195_calcinosis1.49927186
39MP0000678_abnormal_parathyroid_gland1.48517758
40MP0002876_abnormal_thyroid_physiology1.47631074
41MP0002139_abnormal_hepatobiliary_system1.41220449
42MP0001727_abnormal_embryo_implantation1.40573247
43MP0003866_abnormal_defecation1.37391405
44MP0000609_abnormal_liver_physiology1.36028875
45MP0005164_abnormal_response_to1.33666115
46MP0003718_maternal_effect1.30794512
47MP0005670_abnormal_white_adipose1.30608338
48MP0003879_abnormal_hair_cell1.25692022
49MP0003705_abnormal_hypodermis_morpholog1.22378770
50MP0005451_abnormal_body_composition1.21589324
51MP0000013_abnormal_adipose_tissue1.19913659
52MP0000490_abnormal_crypts_of1.19570906
53MP0000639_abnormal_adrenal_gland1.18012456
54MP0003567_abnormal_fetal_cardiomyocyte1.15578621
55MP0000537_abnormal_urethra_morphology1.14893860
56MP0002796_impaired_skin_barrier1.14375178
57MP0010678_abnormal_skin_adnexa1.13578408
58MP0009643_abnormal_urine_homeostasis1.13179679
59MP0000249_abnormal_blood_vessel1.12618157
60MP0003300_gastrointestinal_ulcer1.11305274
61MP0003191_abnormal_cellular_cholesterol1.11047763
62MP0005584_abnormal_enzyme/coenzyme_acti1.07529830
63MP0009384_cardiac_valve_regurgitation1.07425337
64MP0010352_gastrointestinal_tract_polyps1.02614827
65MP0000230_abnormal_systemic_arterial0.99768536
66MP0001849_ear_inflammation0.98719108
67MP0005647_abnormal_sex_gland0.98243576
68MP0009250_abnormal_appendicular_skeleto0.96396765
69MP0005319_abnormal_enzyme/_coenzyme0.96304841
70MP0000627_abnormal_mammary_gland0.95689464
71MP0005058_abnormal_lysosome_morphology0.94850326
72MP0002822_catalepsy0.94241060
73MP0005448_abnormal_energy_balance0.93184998
74MP0001915_intracranial_hemorrhage0.92862198
75MP0000538_abnormal_urinary_bladder0.92449688
76MP0005535_abnormal_body_temperature0.91640279
77MP0002971_abnormal_brown_adipose0.91531860
78MP0002060_abnormal_skin_morphology0.90836947
79MP0001661_extended_life_span0.90783243
80MP0009697_abnormal_copulation0.90734280
81MP0010368_abnormal_lymphatic_system0.89954251
82MP0009333_abnormal_splenocyte_physiolog0.89801827
83MP0004742_abnormal_vestibular_system0.89170167
84MP0001501_abnormal_sleep_pattern0.87416316
85MP0001663_abnormal_digestive_system0.87099706
86MP0004858_abnormal_nervous_system0.86060544
87MP0003385_abnormal_body_wall0.85296186
88MP0004782_abnormal_surfactant_physiolog0.85163911
89MP0009642_abnormal_blood_homeostasis0.83388725
90MP0005503_abnormal_tendon_morphology0.82316927
91MP0002249_abnormal_larynx_morphology0.82216085
92MP0001756_abnormal_urination0.82170898
93MP0000751_myopathy0.82098418
94MP0008469_abnormal_protein_level0.82057582
95MP0002136_abnormal_kidney_physiology0.81269610
96MP0001188_hyperpigmentation0.80289131
97MP0003448_altered_tumor_morphology0.79882340
98MP0003632_abnormal_nervous_system0.79681780
99MP0004270_analgesia0.79199418
100MP0001873_stomach_inflammation0.79105017
101MP0003045_fibrosis0.79022228
102MP0001270_distended_abdomen0.78637888
103MP0009840_abnormal_foam_cell0.78483739
104MP0003436_decreased_susceptibility_to0.77471384
105MP0010329_abnormal_lipoprotein_level0.76218628
106MP0009764_decreased_sensitivity_to0.75012797
107MP0002998_abnormal_bone_remodeling0.74502940
108MP0001845_abnormal_inflammatory_respons0.74352893
109MP0005023_abnormal_wound_healing0.72290386
110MP0005085_abnormal_gallbladder_physiolo0.71742453
111MP0001879_abnormal_lymphatic_vessel0.71167603
112MP0005381_digestive/alimentary_phenotyp0.70783356
113MP0005388_respiratory_system_phenotype0.69572910
114MP0002133_abnormal_respiratory_system0.69572910
115MP0002160_abnormal_reproductive_system0.69435600
116MP0000477_abnormal_intestine_morphology0.69073517
117MP0002928_abnormal_bile_duct0.68695514
118MP0002837_dystrophic_cardiac_calcinosis0.68525531
119MP0009115_abnormal_fat_cell0.67886135
120MP0008872_abnormal_physiological_respon0.67395673
121MP0009785_altered_susceptibility_to0.67385860
122MP0005166_decreased_susceptibility_to0.67033812
123MP0004043_abnormal_pH_regulation0.66219863
124MP0005508_abnormal_skeleton_morphology0.65573386
125MP0010386_abnormal_urinary_bladder0.65421487
126MP0003115_abnormal_respiratory_system0.63788083
127MP0000343_altered_response_to0.63495052
128MP0001533_abnormal_skeleton_physiology0.62564968
129MP0003638_abnormal_response/metabolism_0.62094589
130MP0003938_abnormal_ear_development0.61838204
131MP0004084_abnormal_cardiac_muscle0.61527789
132MP0009780_abnormal_chondrocyte_physiolo0.60738035
133MP0003936_abnormal_reproductive_system0.59375962
134MP0004036_abnormal_muscle_relaxation0.59127766
135MP0002135_abnormal_kidney_morphology0.57268158
136MP0002098_abnormal_vibrissa_morphology0.57056825
137MP0002078_abnormal_glucose_homeostasis0.55579727
138MP0005395_other_phenotype0.54881399
139MP0002896_abnormal_bone_mineralization0.54775091
140MP0005334_abnormal_fat_pad0.53865526
141MP0000598_abnormal_liver_morphology0.53832847
142MP0000858_altered_metastatic_potential0.53618946
143MP0005376_homeostasis/metabolism_phenot0.53529834
144MP0010155_abnormal_intestine_physiology0.51441098
145MP0000767_abnormal_smooth_muscle0.51252834
146MP0004484_altered_response_of0.51176082
147MP0005025_abnormal_response_to0.47440005
148MP0000566_synostosis0.47078840
149MP0003953_abnormal_hormone_level0.45861075
150MP0005666_abnormal_adipose_tissue0.45162335
151MP0005408_hypopigmentation0.42436444
152MP0006082_CNS_inflammation0.42111957
153MP0009763_increased_sensitivity_to0.40239798
154MP0001485_abnormal_pinna_reflex0.37784453
155MP0005501_abnormal_skin_physiology0.37679263
156MP0003303_peritoneal_inflammation0.36724408
157MP0008260_abnormal_autophagy0.35668092
158MP0002166_altered_tumor_susceptibility0.35249694
159MP0003724_increased_susceptibility_to0.35071392
160MP0001790_abnormal_immune_system0.33197029

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)9.63281230
2Spondylolisthesis (HP:0003302)9.44063413
3Vascular tortuosity (HP:0004948)9.08018919
4Aortic dissection (HP:0002647)8.66472753
5Hypobetalipoproteinemia (HP:0003563)7.71645006
6Hydroxyprolinuria (HP:0003080)6.38700342
7Abnormality of proline metabolism (HP:0010907)6.38700342
8Abnormality of monocarboxylic acid metabolism (HP:0010996)6.11230510
9Malnutrition (HP:0004395)5.01688427
10Aortic aneurysm (HP:0004942)4.93209036
11Fat malabsorption (HP:0002630)4.90991522
12Bicuspid aortic valve (HP:0001647)4.42362397
13Xanthomatosis (HP:0000991)4.40816932
14Neoplasm of the heart (HP:0100544)4.37276747
15Hyperglycinuria (HP:0003108)4.25213439
16Abnormality of the vitamin B12 metabolism (HP:0004341)4.24842885
17Mitral valve prolapse (HP:0001634)4.17246096
18Hypolipoproteinemia (HP:0010981)4.12544576
19Ankle contracture (HP:0006466)4.09771418
20Abnormality of vitamin B metabolism (HP:0004340)3.99256594
21Chronic diarrhea (HP:0002028)3.99205393
22Acanthocytosis (HP:0001927)3.97956949
23Abnormality of vitamin metabolism (HP:0100508)3.90534784
24Abnormality of serine family amino acid metabolism (HP:0010894)3.88379593
25Abnormality of glycine metabolism (HP:0010895)3.88379593
26Deep venous thrombosis (HP:0002625)3.85182896
27Cerebral aneurysm (HP:0004944)3.80659298
28Hyperparathyroidism (HP:0000843)3.80427643
29Confusion (HP:0001289)3.76070395
30Abnormality of urine glucose concentration (HP:0011016)3.71033754
31Glycosuria (HP:0003076)3.71033754
32Decreased circulating renin level (HP:0003351)3.69441566
33Premature rupture of membranes (HP:0001788)3.68482955
34Thyroid-stimulating hormone excess (HP:0002925)3.66474340
35Autoimmune thrombocytopenia (HP:0001973)3.58404554
36Nausea (HP:0002018)3.54459749
37Steatorrhea (HP:0002570)3.49002897
38Proximal tubulopathy (HP:0000114)3.46261563
39Thin bony cortex (HP:0002753)3.34662213
40Ventricular fibrillation (HP:0001663)3.32528141
41Abnormality of pyrimidine metabolism (HP:0004353)3.31800590
42Pigmentary retinal degeneration (HP:0001146)3.31741750
43Gastrointestinal dysmotility (HP:0002579)3.29396454
44Hyperammonemia (HP:0001987)3.27984432
45Ulnar bowing (HP:0003031)3.26795375
46Type 1 muscle fiber predominance (HP:0003803)3.25491072
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24182419
48Conjugated hyperbilirubinemia (HP:0002908)3.18895676
49Mesangial abnormality (HP:0001966)3.17611144
50Glomerulonephritis (HP:0000099)3.15414597
51Prolonged partial thromboplastin time (HP:0003645)3.14887547
52Hemorrhage of the eye (HP:0011885)3.02592445
53Nephrolithiasis (HP:0000787)3.02174855
54Hyperlipoproteinemia (HP:0010980)3.00028068
55Complement deficiency (HP:0004431)2.98614265
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.94857665
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94202485
58Intrahepatic cholestasis (HP:0001406)2.93493310
59Hyperthyroidism (HP:0000836)2.93368641
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91756597
61Abnormality of nucleobase metabolism (HP:0010932)2.90379056
62Alkalosis (HP:0001948)2.89901847
63Abdominal situs inversus (HP:0003363)2.88941272
64Abnormality of abdominal situs (HP:0011620)2.88941272
65Mucopolysacchariduria (HP:0008155)2.85998377
66Urinary glycosaminoglycan excretion (HP:0003541)2.85998377
67Wide cranial sutures (HP:0010537)2.85132208
68Right ventricular cardiomyopathy (HP:0011663)2.84891440
69Hypophosphatemia (HP:0002148)2.82984935
70Increased purine levels (HP:0004368)2.79613908
71Hyperuricemia (HP:0002149)2.79613908
72Potter facies (HP:0002009)2.78155799
73Facial shape deformation (HP:0011334)2.78155799
74Hyperphosphaturia (HP:0003109)2.76502483
75Abnormal urine phosphate concentration (HP:0012599)2.74746661
76Megaloblastic anemia (HP:0001889)2.73940029
77Abnormality of purine metabolism (HP:0004352)2.71394186
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64665421
79Abnormality of polysaccharide metabolism (HP:0011012)2.64665421
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64665421
81Vacuolated lymphocytes (HP:0001922)2.62093877
82Epidermoid cyst (HP:0200040)2.61813616
83Metabolic acidosis (HP:0001942)2.57575159
84Follicular hyperkeratosis (HP:0007502)2.57156950
85Systemic lupus erythematosus (HP:0002725)2.54701511
86Arachnodactyly (HP:0001166)2.48504304
87Radial bowing (HP:0002986)2.44504043
88Protrusio acetabuli (HP:0003179)2.43240097
89Metabolic alkalosis (HP:0200114)2.43106720
90Fragile skin (HP:0001030)2.41696305
91Congenital sensorineural hearing impairment (HP:0008527)2.41039325
92Mildly elevated creatine phosphokinase (HP:0008180)2.40146407
93Atrophic scars (HP:0001075)2.38570491
94Nephritis (HP:0000123)2.35278471
95Joint hemorrhage (HP:0005261)2.34001807
96Abnormality of sulfur amino acid metabolism (HP:0004339)2.32468374
97Cervical subluxation (HP:0003308)2.32280123
98Emphysema (HP:0002097)2.31630970
99Broad metatarsal (HP:0001783)2.30733069
100Spastic diplegia (HP:0001264)2.30154445
101Tarsal synostosis (HP:0008368)2.29896235
102Gout (HP:0001997)2.28053011
103Dysostosis multiplex (HP:0000943)2.27994369
104Irritability (HP:0000737)2.25993310
105Rickets (HP:0002748)2.23261240
106Petechiae (HP:0000967)2.22596895
107Cerebral palsy (HP:0100021)2.20223788
108Aneurysm (HP:0002617)2.19389247
109Increased variability in muscle fiber diameter (HP:0003557)2.18984456
110Poikilocytosis (HP:0004447)2.18649282
111Bowing of the arm (HP:0006488)2.18439035
112Bowed forearm bones (HP:0003956)2.18439035
113Focal segmental glomerulosclerosis (HP:0000097)2.17591557
114Purpura (HP:0000979)2.16017600
115Pancreatitis (HP:0001733)2.14897671
116Abnormality of complement system (HP:0005339)2.14856670
117Peritonitis (HP:0002586)2.13868219
118Hyporeflexia of lower limbs (HP:0002600)2.12548787
119Delayed CNS myelination (HP:0002188)2.12022972
120Slender build (HP:0001533)2.09988721
121Synostosis involving bones of the feet (HP:0009140)2.09662478
122Synostosis involving bones of the lower limbs (HP:0009138)2.09662478
123Hyperglycinemia (HP:0002154)2.09125782
124Rectal prolapse (HP:0002035)2.09043279
125Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08744022
126Dicarboxylic aciduria (HP:0003215)2.08744022
127Posterior subcapsular cataract (HP:0007787)2.07858992
128Hypotension (HP:0002615)2.06991348
129Ileus (HP:0002595)2.06808274
130Widely patent fontanelles and sutures (HP:0004492)2.05856134
131Tibial bowing (HP:0002982)2.05821944
132Abnormal enzyme/coenzyme activity (HP:0012379)2.03445627
133Hyperactive renin-angiotensin system (HP:0000841)2.02218273
134Abnormality of alkaline phosphatase activity (HP:0004379)2.01656269
135Vascular calcification (HP:0004934)2.00842658
136Arterial tortuosity (HP:0005116)10.1221501
137Femoral bowing (HP:0002980)1.96983227
138Osteolytic defects of the hand bones (HP:0009699)1.95399221
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.95399221
140Syncope (HP:0001279)1.94225868
141Renal tubular acidosis (HP:0001947)1.92553564
142Generalized aminoaciduria (HP:0002909)1.92197762
143Testicular atrophy (HP:0000029)1.91834085
144Delayed epiphyseal ossification (HP:0002663)1.91713487
145Lethargy (HP:0001254)1.91196988
146Prolonged QT interval (HP:0001657)1.90761715
147Eczematoid dermatitis (HP:0000976)1.90433975
148Enlarged epiphyses (HP:0010580)1.90118909
149Villous atrophy (HP:0011473)1.89895019
150Abnormality of small intestinal villus morphology (HP:0011472)1.89895019
151Spinal rigidity (HP:0003306)1.89771074
152Soft skin (HP:0000977)1.88879593
153Facial diplegia (HP:0001349)1.86785368
154Protuberant abdomen (HP:0001538)1.86680064
155Abnormality of serum amino acid levels (HP:0003112)1.85488138
156Delayed closure of the anterior fontanelle (HP:0001476)1.85422763
157Increased connective tissue (HP:0009025)1.85212806
158Hypophosphatemic rickets (HP:0004912)1.83945846
159Elevated alkaline phosphatase (HP:0003155)1.83278641
160Elbow flexion contracture (HP:0002987)1.82656342
161Renal tubular dysfunction (HP:0000124)1.82471741
162Dilatation of the ascending aorta (HP:0005111)1.81292199
163Abdominal distention (HP:0003270)1.80125065
164Symptomatic seizures (HP:0011145)1.79558384
165Striae distensae (HP:0001065)1.79487308
166Hyperbilirubinemia (HP:0002904)1.78427243
167Abnormality of renin-angiotensin system (HP:0000847)1.77886515
168Osteomalacia (HP:0002749)1.77817299
169Hypercholesterolemia (HP:0003124)1.77099851
170Abnormality of skeletal muscle fiber size (HP:0012084)1.75558328
171Vomiting (HP:0002013)1.73389459
172Alopecia of scalp (HP:0002293)1.73288568
173Increased mean platelet volume (HP:0011877)1.70640638
174Polycythemia (HP:0001901)1.69990460
175Aplastic anemia (HP:0001915)1.66946419
176Absent frontal sinuses (HP:0002688)1.66912098
177Abnormal hemoglobin (HP:0011902)1.66774130
178Scapular winging (HP:0003691)1.64355263
179Autoimmune hemolytic anemia (HP:0001890)1.63371516
180Ulnar deviation of the wrist (HP:0003049)1.62707634
181Bilateral sensorineural hearing impairment (HP:0008619)1.62478877
182Blue sclerae (HP:0000592)1.61859179
183Tetraparesis (HP:0002273)1.59449571
184Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.58918836
185Inguinal hernia (HP:0000023)1.58513332
186Abnormality of the costochondral junction (HP:0000919)1.58047938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.78600889
2MYLK5.38382632
3TGFBR24.01493895
4TTN3.87448142
5LMTK23.33654678
6TAOK33.06458723
7MST1R2.89531611
8ERN12.63596061
9MST42.52129875
10EPHB12.50148203
11MAPKAPK32.49181460
12PIK3CG2.38539854
13TESK22.33788529
14DMPK2.01203543
15PAK21.89759318
16PTK61.89388950
17EPHB21.85100895
18MET1.82517605
19TRIB31.72331045
20MAP3K121.71935208
21PTK21.71427005
22PDGFRA1.70060882
23STK391.69777823
24RIPK11.68825452
25PAK41.68035505
26FGFR21.62405924
27FER1.59575617
28TESK11.59378369
29MAP3K21.59040517
30PRKG21.52806655
31FRK1.47460458
32OXSR11.47289796
33LRRK21.47032688
34DDR21.42080307
35MAP4K11.32793639
36PTK2B1.23226810
37RPS6KB21.20521071
38PRPF4B1.15687264
39NME11.13865690
40TNIK1.11800256
41TIE11.11770305
42MAP3K101.09935519
43AKT31.09033690
44NTRK11.07392634
45LIMK11.05832253
46PAK31.05489651
47CDC42BPA1.04267770
48LATS11.01700501
49PAK11.00944630
50PRKACG0.98881525
51MAP3K110.97328998
52MAP3K70.95846462
53MAP3K10.95215811
54MAPK110.93479604
55PDK20.93316054
56EEF2K0.93181009
57STK380.92910338
58PKN20.91963186
59STK240.91124755
60EPHA30.87965575
61KSR20.85197565
62PRKAA20.83683170
63DYRK1B0.82742975
64JAK30.81877784
65RIPK40.79897230
66KDR0.79647837
67FGFR40.78712727
68PRKCZ0.78268862
69ROCK10.77763843
70DAPK30.72033207
71ABL20.70360834
72MAP2K60.69516987
73MAP2K20.67566129
74MAP3K30.67128502
75PDPK10.67105221
76ROCK20.66761070
77BMX0.63530582
78SRC0.62995799
79ILK0.62192633
80STK100.61380555
81PIM10.59435976
82TAOK10.58389472
83PRKD10.57669594
84CSF1R0.55022697
85JAK10.52114037
86TYK20.47690163
87PDGFRB0.46687198
88MUSK0.46652967
89MAP2K10.45947687
90RET0.45470768
91ZAP700.44829764
92GRK10.44574069
93RPS6KA20.43103610
94EPHA40.41826045
95GSK3A0.40332823
96JAK20.39576904
97PRKCI0.39516786
98IKBKE0.38362663
99CAMK2D0.38081893
100GRK60.37834676
101PRKCD0.37772562
102CDK60.36737026
103CASK0.36495681
104IRAK30.36465599
105TRPM70.35161615
106FYN0.34839597
107PDK10.34467459
108FGFR10.34324971
109IRAK10.33885031
110IGF1R0.33246184
111CAMK2G0.32995535
112ERBB20.32812141
113MAPKAPK20.32738599
114CAMK10.32513888
115TBK10.32374559
116PRKACA0.29974316
117BMPR20.29642339
118PIM20.28559244
119ICK0.28419249
120CSK0.28073057
121CAMKK10.27353044
122STK30.27045356
123CDK190.26796839
124MAPK40.26728790
125CAMK2B0.25820022
126NLK0.25768105
127ALK0.25709929
128DAPK20.25608196
129EPHA20.25465817
130SIK10.25308946
131ITK0.25088040
132FGFR30.25039709
133TYRO30.24709610
134SMG10.24156425
135MAP3K90.23844842
136MAP3K80.22476026
137SYK0.22427227
138AKT20.21650131
139ABL10.20711770
140LATS20.20567079
141PIK3CA0.19951695
142PRKCA0.19573321
143EGFR0.19493384
144PRKG10.19384776
145MATK0.19334378
146PRKCQ0.19133040
147LYN0.18139243

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049782.76073978
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.66945626
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.57757235
4Nitrogen metabolism_Homo sapiens_hsa009102.49915543
5Drug metabolism - other enzymes_Homo sapiens_hsa009832.42398438
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31109045
7Vitamin digestion and absorption_Homo sapiens_hsa049772.16098317
8Linoleic acid metabolism_Homo sapiens_hsa005912.06853158
9Rheumatoid arthritis_Homo sapiens_hsa053232.01137850
10Other glycan degradation_Homo sapiens_hsa005112.00176269
11Leishmaniasis_Homo sapiens_hsa051401.98973789
12ECM-receptor interaction_Homo sapiens_hsa045121.96223846
13Caffeine metabolism_Homo sapiens_hsa002321.96147295
14Amoebiasis_Homo sapiens_hsa051461.94766961
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.93036049
16Fat digestion and absorption_Homo sapiens_hsa049751.91253725
17Histidine metabolism_Homo sapiens_hsa003401.91000484
18Bile secretion_Homo sapiens_hsa049761.88505563
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.86428586
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.80291804
21Fructose and mannose metabolism_Homo sapiens_hsa000511.74404780
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73059525
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62419955
24Phenylalanine metabolism_Homo sapiens_hsa003601.62191762
25Complement and coagulation cascades_Homo sapiens_hsa046101.60530871
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.55078562
27Tryptophan metabolism_Homo sapiens_hsa003801.54160654
28Lysosome_Homo sapiens_hsa041421.52440351
29Thyroid hormone synthesis_Homo sapiens_hsa049181.51994885
30Dilated cardiomyopathy_Homo sapiens_hsa054141.51210694
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48054038
32Staphylococcus aureus infection_Homo sapiens_hsa051501.43655306
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42825088
34TGF-beta signaling pathway_Homo sapiens_hsa043501.40420242
35Protein digestion and absorption_Homo sapiens_hsa049741.36457923
36Tuberculosis_Homo sapiens_hsa051521.35635932
37Malaria_Homo sapiens_hsa051441.34965513
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32993032
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31622778
40Osteoclast differentiation_Homo sapiens_hsa043801.29611271
41Focal adhesion_Homo sapiens_hsa045101.22588847
42Renin-angiotensin system_Homo sapiens_hsa046141.22212116
43Chronic myeloid leukemia_Homo sapiens_hsa052201.21295899
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.21149107
45Toxoplasmosis_Homo sapiens_hsa051451.19999660
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19252388
47Pancreatic cancer_Homo sapiens_hsa052121.19163339
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16458986
49Pertussis_Homo sapiens_hsa051331.14744828
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14265072
51Autoimmune thyroid disease_Homo sapiens_hsa053201.13298313
52Retinol metabolism_Homo sapiens_hsa008301.12435728
53Proteoglycans in cancer_Homo sapiens_hsa052051.12402334
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11228337
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10752506
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10207818
57Tyrosine metabolism_Homo sapiens_hsa003501.09453671
58Gastric acid secretion_Homo sapiens_hsa049711.08158600
59Sphingolipid metabolism_Homo sapiens_hsa006001.06334161
60Glutathione metabolism_Homo sapiens_hsa004801.02406094
61Hematopoietic cell lineage_Homo sapiens_hsa046401.01987227
62Colorectal cancer_Homo sapiens_hsa052100.97372470
63Steroid biosynthesis_Homo sapiens_hsa001000.96292176
64Butanoate metabolism_Homo sapiens_hsa006500.94002161
65Peroxisome_Homo sapiens_hsa041460.92475473
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92444320
67Starch and sucrose metabolism_Homo sapiens_hsa005000.91441454
68Sulfur metabolism_Homo sapiens_hsa009200.90587488
69Renal cell carcinoma_Homo sapiens_hsa052110.88932238
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88906464
71Arginine biosynthesis_Homo sapiens_hsa002200.85216589
72beta-Alanine metabolism_Homo sapiens_hsa004100.83531284
73PPAR signaling pathway_Homo sapiens_hsa033200.80517652
74Pentose phosphate pathway_Homo sapiens_hsa000300.77647065
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77456082
76Salivary secretion_Homo sapiens_hsa049700.76285397
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75615082
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75365880
79Fatty acid metabolism_Homo sapiens_hsa012120.73915923
80Arginine and proline metabolism_Homo sapiens_hsa003300.73190689
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70272017
82Galactose metabolism_Homo sapiens_hsa000520.69883132
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69417848
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68487687
85Biosynthesis of amino acids_Homo sapiens_hsa012300.67734838
86Renin secretion_Homo sapiens_hsa049240.67635280
87Ether lipid metabolism_Homo sapiens_hsa005650.66373549
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65753262
89Tight junction_Homo sapiens_hsa045300.64859039
90Vibrio cholerae infection_Homo sapiens_hsa051100.64733395
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63836250
92Salmonella infection_Homo sapiens_hsa051320.63138280
93Asthma_Homo sapiens_hsa053100.63104609
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62981479
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.61481541
96ABC transporters_Homo sapiens_hsa020100.61149886
97Phagosome_Homo sapiens_hsa041450.58425099
98Hippo signaling pathway_Homo sapiens_hsa043900.57811182
99Pyruvate metabolism_Homo sapiens_hsa006200.56326197
100Carbon metabolism_Homo sapiens_hsa012000.55492531
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55440314
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55106395
103Glycerolipid metabolism_Homo sapiens_hsa005610.54652250
104Sulfur relay system_Homo sapiens_hsa041220.53771197
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51132444
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49793179
107Fatty acid degradation_Homo sapiens_hsa000710.49369497
108Adherens junction_Homo sapiens_hsa045200.49353117
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.48848809
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48807417
111Folate biosynthesis_Homo sapiens_hsa007900.46949591
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.45366432
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44541478
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43861432
115Chemical carcinogenesis_Homo sapiens_hsa052040.43473391
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.43365111
117Small cell lung cancer_Homo sapiens_hsa052220.43303883
118FoxO signaling pathway_Homo sapiens_hsa040680.42201199
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41747310
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41194717
121Rap1 signaling pathway_Homo sapiens_hsa040150.40003867
122Arachidonic acid metabolism_Homo sapiens_hsa005900.39396826
123Endocytosis_Homo sapiens_hsa041440.35418829
124Metabolic pathways_Homo sapiens_hsa011000.35187025
125Allograft rejection_Homo sapiens_hsa053300.34042548
126Propanoate metabolism_Homo sapiens_hsa006400.33617122
127Ras signaling pathway_Homo sapiens_hsa040140.33222085
128MicroRNAs in cancer_Homo sapiens_hsa052060.32772792
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31420105
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30573107
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29895136
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28477196
133Pancreatic secretion_Homo sapiens_hsa049720.28264061
134Platelet activation_Homo sapiens_hsa046110.27967669
135Insulin resistance_Homo sapiens_hsa049310.27780365
136Graft-versus-host disease_Homo sapiens_hsa053320.26794081
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26137778
138Fatty acid biosynthesis_Homo sapiens_hsa000610.24551941
139Fatty acid elongation_Homo sapiens_hsa000620.22525159
140Vitamin B6 metabolism_Homo sapiens_hsa007500.21577713
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.20793301
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.16714490
143Prion diseases_Homo sapiens_hsa050200.14653949
144Type I diabetes mellitus_Homo sapiens_hsa049400.13163727
145Glucagon signaling pathway_Homo sapiens_hsa049220.12938498
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01720308
147Cocaine addiction_Homo sapiens_hsa050300.00201637
148AMPK signaling pathway_Homo sapiens_hsa04152-0.0419190
149Serotonergic synapse_Homo sapiens_hsa04726-0.0338050
150African trypanosomiasis_Homo sapiens_hsa05143-0.0069043
151Antigen processing and presentation_Homo sapiens_hsa04612-0.0015217
152Hepatitis C_Homo sapiens_hsa05160-0.0001069

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