PRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron coordination entity transport (GO:1901678)8.49535736
2glutathione biosynthetic process (GO:0006750)6.57799502
3nonribosomal peptide biosynthetic process (GO:0019184)5.99938592
4magnesium ion transport (GO:0015693)5.91693766
5cell-cell junction maintenance (GO:0045217)5.80505668
6ovulation from ovarian follicle (GO:0001542)5.66138787
7calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.44999747
8regulation of regulatory T cell differentiation (GO:0045589)5.38917089
9cytokine production involved in immune response (GO:0002367)5.15099146
10cell junction maintenance (GO:0034331)4.60515375
11one-carbon compound transport (GO:0019755)4.54291124
12peptide biosynthetic process (GO:0043043)4.49517383
13positive regulation of vesicle fusion (GO:0031340)4.32691397
14response to lipoprotein particle (GO:0055094)4.23764165
15sleep (GO:0030431)4.19198912
16mannose metabolic process (GO:0006013)4.17530111
17positive regulation of gastrulation (GO:2000543)4.14906360
18regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.11608726
19amyloid precursor protein catabolic process (GO:0042987)4.08009206
20polyol transport (GO:0015791)4.06465852
21protein targeting to Golgi (GO:0000042)4.06205554
22regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.01533182
23mitochondrial calcium ion transport (GO:0006851)4.00999423
24peptide catabolic process (GO:0043171)4.00938394
25tolerance induction (GO:0002507)3.99170312
26heart valve formation (GO:0003188)3.97836657
27T cell mediated immunity (GO:0002456)3.96573913
28organelle disassembly (GO:1903008)3.92101487
29production of molecular mediator of immune response (GO:0002440)3.83700747
30phospholipid homeostasis (GO:0055091)3.79841604
31establishment of protein localization to Golgi (GO:0072600)3.78883755
32nephron tubule development (GO:0072080)3.78206106
33cellular component maintenance (GO:0043954)3.76350469
34mannosylation (GO:0097502)3.75792132
35regulation of cholesterol metabolic process (GO:0090181)3.72930711
36establishment of endothelial barrier (GO:0061028)3.72671581
37arginine catabolic process (GO:0006527)3.68350731
38embryonic heart tube development (GO:0035050)3.68122272
39regulation of gastrulation (GO:0010470)3.67277005
40parturition (GO:0007567)3.67256704
41leukotriene biosynthetic process (GO:0019370)3.65796736
42negative regulation of T cell mediated immunity (GO:0002710)3.64051095
43nitric oxide mediated signal transduction (GO:0007263)3.58145085
44retrograde transport, vesicle recycling within Golgi (GO:0000301)3.58104812
45positive regulation of cholesterol transport (GO:0032376)3.57763538
46positive regulation of sterol transport (GO:0032373)3.57763538
47regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.53516791
48mRNA transcription from RNA polymerase II promoter (GO:0042789)3.51621780
49negative regulation of metanephros development (GO:0072217)3.49255174
50ear development (GO:0043583)3.49186452
51renal tubule development (GO:0061326)3.48273856
52negative regulation of lipid storage (GO:0010888)3.45413630
53high-density lipoprotein particle remodeling (GO:0034375)3.43684838
54negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.31552671
55inositol phosphate-mediated signaling (GO:0048016)3.31500592
56regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.30691293
57positive regulation of cholesterol efflux (GO:0010875)3.28605235
58tyrosine phosphorylation of STAT protein (GO:0007260)3.28030643
59regulation of cholesterol biosynthetic process (GO:0045540)3.26887504
60positive regulation of T cell differentiation in thymus (GO:0033089)3.24285415
61nephron tubule formation (GO:0072079)3.23590312
62endothelial cell development (GO:0001885)3.21670090
63positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.20733807
64positive regulation of lipoprotein lipase activity (GO:0051006)3.20346855
65positive regulation of triglyceride lipase activity (GO:0061365)3.20346855
66heart trabecula formation (GO:0060347)3.20052089
67platelet dense granule organization (GO:0060155)3.19040620
68mRNA transcription (GO:0009299)3.17860342
69regulation of protein kinase C signaling (GO:0090036)3.17567144
70ovulation (GO:0030728)3.11314279
71positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.08405796
72positive regulation of cell cycle G2/M phase transition (GO:1902751)3.08405796
73endoderm formation (GO:0001706)3.07114735
74mitotic G1/S transition checkpoint (GO:0044819)3.01037870
75reverse cholesterol transport (GO:0043691)2.97497016
76membrane raft organization (GO:0031579)2.97174661
77cellular response to exogenous dsRNA (GO:0071360)2.96790965
78synaptic vesicle endocytosis (GO:0048488)2.96680931
79negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.96652361
80regulation of ARF GTPase activity (GO:0032312)2.95441814
81toxin transport (GO:1901998)2.91497157
82nephron epithelium development (GO:0072009)2.89945471
83cellular response to gamma radiation (GO:0071480)2.86429223
84regulation of cytokine production involved in inflammatory response (GO:1900015)2.85417906
85positive regulation of tolerance induction (GO:0002645)2.85193321
86arginine metabolic process (GO:0006525)2.84203688
87protein localization to Golgi apparatus (GO:0034067)2.83320362
88response to inactivity (GO:0014854)2.81608999
89phospholipid efflux (GO:0033700)2.77143382
90negative regulation of cytokine secretion (GO:0050710)2.73232077
91negative regulation of T cell receptor signaling pathway (GO:0050860)2.72848236
92negative regulation of cAMP-mediated signaling (GO:0043951)2.72009346
93negative regulation of Rho protein signal transduction (GO:0035024)2.71159771
94regulation of mesoderm development (GO:2000380)2.70868823
95positive regulation of steroid biosynthetic process (GO:0010893)2.70712547
96metanephric nephron tubule development (GO:0072234)2.69793745
97metanephric tubule development (GO:0072170)2.69793745
98regulation of cholesterol esterification (GO:0010872)2.68460125
99negative regulation of T cell differentiation in thymus (GO:0033085)2.67251083
100amyloid precursor protein metabolic process (GO:0042982)2.66840556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.28121453
2ESR1_15608294_ChIP-ChIP_MCF-7_Human4.62094346
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41960858
4SRY_22984422_ChIP-ChIP_TESTIS_Rat3.12987269
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.71042745
6ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.44268050
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25899441
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24865943
9TP53_16413492_ChIP-PET_HCT116_Human2.13778838
10DROSHA_22980978_ChIP-Seq_HELA_Human2.12254405
11ZNF274_21170338_ChIP-Seq_K562_Hela1.94561845
12IRF8_22096565_ChIP-ChIP_GC-B_Human1.92262182
13RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.87740342
14SCL_19346495_ChIP-Seq_HPC-7_Human1.84721977
15JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83124945
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.78247273
17JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73787365
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.66533105
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.58161031
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57453851
21YY1_22570637_ChIP-Seq_MALME-3M_Human1.54881767
22BCAT_22108803_ChIP-Seq_LS180_Human1.54581692
23TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.50562821
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.45488075
25ERA_21632823_ChIP-Seq_H3396_Human1.45433427
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43712753
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39386151
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.37719136
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34030658
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33487872
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32641504
32PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32287937
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31777181
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30414730
35STAT1_20625510_ChIP-Seq_HELA_Human1.27562781
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27373564
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27109326
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.24982274
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21479846
40SMAD4_21741376_ChIP-Seq_HESCs_Human1.20501973
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19431910
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.19265146
43* BCL6_27268052_Chip-Seq_Bcells_Human1.18519814
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16030375
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15606588
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15606588
47RUNX_20019798_ChIP-Seq_JUKART_Human1.14750046
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14217546
49STAT1_17558387_ChIP-Seq_HELA_Human1.13171629
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.13111890
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.13015708
52RAC3_21632823_ChIP-Seq_H3396_Human1.12393607
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11528864
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.11283444
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10334593
56SMC4_20622854_ChIP-Seq_HELA_Human1.09852863
57P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09558632
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08790333
59VDR_24787735_ChIP-Seq_THP-1_Human1.08570936
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08019815
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07758960
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05577227
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.05093758
64TCF4_22108803_ChIP-Seq_LS180_Human1.05025111
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04723083
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03839407
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03178463
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.02530130
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02237934
70GATA3_26560356_Chip-Seq_TH2_Human1.01290365
71KLF5_25053715_ChIP-Seq_YYC3_Human1.01137827
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00347556
73TP53_23651856_ChIP-Seq_MEFs_Mouse0.99732281
74SMAD3_21741376_ChIP-Seq_HESCs_Human0.99421771
75OCT1_27270436_Chip-Seq_PROSTATE_Human0.98929142
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98517319
77GBX2_23144817_ChIP-Seq_PC3_Human0.97547637
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95120133
79NOTCH1_21737748_ChIP-Seq_TLL_Human0.94960107
80GATA1_19941826_ChIP-Seq_K562_Human0.94213954
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93854782
82RUNX1_27514584_Chip-Seq_MCF-7_Human0.93747003
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93117309
84OCT4_20526341_ChIP-Seq_ESCs_Human0.92757743
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90731136
86NANOG_20526341_ChIP-Seq_ESCs_Human0.89467457
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89372781
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88200471
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85036330
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84093635
91TAF2_19829295_ChIP-Seq_ESCs_Human0.82752865
92AR_19668381_ChIP-Seq_PC3_Human0.80240226
93SPI1_20517297_ChIP-Seq_HL60_Human0.79759258
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79356257
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78804118
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78391453
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77285798
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.77030331
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.76895234
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76250559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001501_abnormal_sleep_pattern3.93915145
2MP0005645_abnormal_hypothalamus_physiol3.91238104
3MP0009840_abnormal_foam_cell3.79161289
4MP0002877_abnormal_melanocyte_morpholog3.72712768
5MP0002009_preneoplasia3.17522753
6MP0001873_stomach_inflammation3.08053481
7MP0003191_abnormal_cellular_cholesterol3.02808457
8MP0003828_pulmonary_edema2.75726773
9MP0000013_abnormal_adipose_tissue2.63878441
10MP0004019_abnormal_vitamin_homeostasis2.58392687
11MP0003183_abnormal_peptide_metabolism2.54248488
12MP0004185_abnormal_adipocyte_glucose2.44364149
13MP0004782_abnormal_surfactant_physiolog2.42135734
14MP0002909_abnormal_adrenal_gland2.41745389
15MP0005083_abnormal_biliary_tract2.33794968
16MP0002127_abnormal_cardiovascular_syste2.27410392
17MP0005646_abnormal_pituitary_gland2.23985453
18MP0005503_abnormal_tendon_morphology2.14804256
19MP0008775_abnormal_heart_ventricle2.12066212
20MP0004858_abnormal_nervous_system2.11138694
21MP0004947_skin_inflammation2.02696177
22MP0004859_abnormal_synaptic_plasticity2.01230520
23MP0003436_decreased_susceptibility_to1.95085006
24MP0003879_abnormal_hair_cell1.78802430
25MP0001346_abnormal_lacrimal_gland1.68116268
26MP0009333_abnormal_splenocyte_physiolog1.66629596
27MP0005167_abnormal_blood-brain_barrier1.58345910
28MP0005084_abnormal_gallbladder_morpholo1.52995476
29MP0008995_early_reproductive_senescence1.50499507
30MP0002254_reproductive_system_inflammat1.49423038
31MP0001919_abnormal_reproductive_system1.48047158
32MP0003646_muscle_fatigue1.45925633
33MP0004043_abnormal_pH_regulation1.45829432
34MP0003880_abnormal_central_pattern1.45581990
35MP0000467_abnormal_esophagus_morphology1.44620058
36MP0005389_reproductive_system_phenotype1.44602693
37MP0001502_abnormal_circadian_rhythm1.44125092
38MP0001765_abnormal_ion_homeostasis1.44032901
39MP0002160_abnormal_reproductive_system1.41935695
40MP0003943_abnormal_hepatobiliary_system1.40578922
41MP0003941_abnormal_skin_development1.37509696
42MP0005257_abnormal_intraocular_pressure1.34523204
43MP0000681_abnormal_thyroid_gland1.30619434
44MP0000579_abnormal_nail_morphology1.30446767
45MP0000427_abnormal_hair_cycle1.28752750
46MP0002933_joint_inflammation1.26156667
47MP0002295_abnormal_pulmonary_circulatio1.21390389
48MP0002136_abnormal_kidney_physiology1.20069138
49MP0002102_abnormal_ear_morphology1.19587456
50MP0000566_synostosis1.17261188
51MP0000613_abnormal_salivary_gland1.15866262
52MP0000639_abnormal_adrenal_gland1.13343484
53MP0001756_abnormal_urination1.12770023
54MP0000749_muscle_degeneration1.09603673
55MP0009745_abnormal_behavioral_response1.07152553
56MP0008872_abnormal_physiological_respon1.05501701
57MP0000465_gastrointestinal_hemorrhage1.03089597
58MP0002876_abnormal_thyroid_physiology1.02249994
59MP0002064_seizures0.98389390
60MP0001851_eye_inflammation0.93417181
61MP0001533_abnormal_skeleton_physiology0.92906005
62MP0003635_abnormal_synaptic_transmissio0.91100554
63MP0004264_abnormal_extraembryonic_tissu0.90684942
64MP0000685_abnormal_immune_system0.90590164
65MP0003045_fibrosis0.88658590
66MP0000678_abnormal_parathyroid_gland0.87732381
67MP0003938_abnormal_ear_development0.86932703
68MP0002184_abnormal_innervation0.86607173
69MP0005332_abnormal_amino_acid0.86278983
70MP0005584_abnormal_enzyme/coenzyme_acti0.85525054
71MP0002405_respiratory_system_inflammati0.85510080
72MP0010329_abnormal_lipoprotein_level0.84007454
73MP0002269_muscular_atrophy0.82917834
74MP0001968_abnormal_touch/_nociception0.81771134
75MP0002998_abnormal_bone_remodeling0.81332595
76MP0000762_abnormal_tongue_morphology0.81096722
77MP0002557_abnormal_social/conspecific_i0.80007570
78MP0005375_adipose_tissue_phenotype0.79869544
79MP0006138_congestive_heart_failure0.77971919
80MP0005197_abnormal_uvea_morphology0.77679603
81MP0005595_abnormal_vascular_smooth0.76879412
82MP0005666_abnormal_adipose_tissue0.75649358
83MP0009643_abnormal_urine_homeostasis0.71543036
84MP0001879_abnormal_lymphatic_vessel0.71529598
85MP0005365_abnormal_bile_salt0.70531477
86MP0003638_abnormal_response/metabolism_0.69217897
87MP0001986_abnormal_taste_sensitivity0.69126718
88MP0005671_abnormal_response_to0.68430151
89MP0003763_abnormal_thymus_physiology0.64870522
90MP0003866_abnormal_defecation0.64300423
91MP0001486_abnormal_startle_reflex0.64255672
92MP0009384_cardiac_valve_regurgitation0.64221710
93MP0002166_altered_tumor_susceptibility0.63977666
94MP0004130_abnormal_muscle_cell0.63839773
95MP0000383_abnormal_hair_follicle0.63507877
96MP0002229_neurodegeneration0.62802230
97MP0002733_abnormal_thermal_nociception0.62398478
98MP0001663_abnormal_digestive_system0.61647956
99MP0001800_abnormal_humoral_immune0.60987278
100MP0004484_altered_response_of0.60836119

Predicted human phenotypes

RankGene SetZ-score
1Tetany (HP:0001281)9.12829783
2Hypomagnesemia (HP:0002917)8.19704592
3Abnormal drinking behavior (HP:0030082)6.79275458
4Polydipsia (HP:0001959)6.79275458
5Abnormality of magnesium homeostasis (HP:0004921)6.76716576
6Stomach cancer (HP:0012126)4.98711362
7Enlarged epiphyses (HP:0010580)4.41250741
8Polyuria (HP:0000103)4.26932436
9Split foot (HP:0001839)4.15353004
10Abnormality of the vertebral endplates (HP:0005106)4.09534776
11Hyperuricemia (HP:0002149)3.96685835
12Increased purine levels (HP:0004368)3.96685835
13Flattened epiphyses (HP:0003071)3.91851454
14Renal tubular acidosis (HP:0001947)3.88630919
15Stridor (HP:0010307)3.73951887
16Fibular aplasia (HP:0002990)3.67505398
17Hypothermia (HP:0002045)3.60776990
18Abnormal urine output (HP:0012590)3.51145755
19Spinal muscular atrophy (HP:0007269)3.47179546
20Thyroid-stimulating hormone excess (HP:0002925)3.33158880
21Recurrent bacterial skin infections (HP:0005406)3.31890341
22Degeneration of anterior horn cells (HP:0002398)3.31001017
23Abnormality of the anterior horn cell (HP:0006802)3.31001017
24Polygenic inheritance (HP:0010982)3.28979630
25Infertility (HP:0000789)3.18211671
26Abnormality of renal excretion (HP:0011036)2.89341729
27Hypercalciuria (HP:0002150)2.89112730
28Abnormality of glycolipid metabolism (HP:0010969)2.87709812
29Abnormality of liposaccharide metabolism (HP:0010968)2.87709812
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.87709812
31Diaphragmatic weakness (HP:0009113)2.87166804
32Synostosis involving the elbow (HP:0003938)2.80243907
33Humeroradial synostosis (HP:0003041)2.80243907
34Focal segmental glomerulosclerosis (HP:0000097)2.62316930
35Aplasia of the phalanges of the hand (HP:0009802)2.47922253
36Aplasia involving bones of the extremities (HP:0009825)2.47922253
37Aplasia involving bones of the upper limbs (HP:0009823)2.47922253
38Coxa vara (HP:0002812)2.45838806
39Eczematoid dermatitis (HP:0000976)2.44995156
40Abnormality of the epiphysis of the femoral head (HP:0010574)2.43574931
41Renal tubular dysfunction (HP:0000124)2.39055584
42Barrel-shaped chest (HP:0001552)2.35296403
43Abnormality of purine metabolism (HP:0004352)2.33115425
44Hypokinesia (HP:0002375)2.32921796
45Conical tooth (HP:0000698)2.29697746
46Weak cry (HP:0001612)2.27333754
47Nephrocalcinosis (HP:0000121)2.26679403
48Chronic diarrhea (HP:0002028)2.26377725
49Abnormality of femoral epiphyses (HP:0006499)2.26097820
50Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.26097820
51Septate vagina (HP:0001153)2.25264610
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23277712
53Abnormality of the femoral head (HP:0003368)2.22053307
54Recurrent abscess formation (HP:0002722)2.21403355
55Hypoplastic labia majora (HP:0000059)2.15963759
56Hypoplasia of the radius (HP:0002984)2.15475295
57Poor speech (HP:0002465)2.15058279
58Nonimmune hydrops fetalis (HP:0001790)2.14277882
59Anterior segment dysgenesis (HP:0007700)2.13144225
60Type II lissencephaly (HP:0007260)2.10557278
61Severe combined immunodeficiency (HP:0004430)2.09168027
62Large for gestational age (HP:0001520)2.06376778
63Abnormal finger flexion creases (HP:0006143)1.98258680
64EMG: neuropathic changes (HP:0003445)1.95825919
65Mesangial abnormality (HP:0001966)1.95588395
66Abnormality of the labia majora (HP:0012881)1.94459252
67Dysautonomia (HP:0002459)1.93064093
68Hematochezia (HP:0002573)1.92810661
69Joint swelling (HP:0001386)1.92327235
70Cerebellar dysplasia (HP:0007033)1.91128274
71Hydroureter (HP:0000072)1.86910550
72Aplasia/Hypoplasia of the fibula (HP:0006492)1.85489640
73Opisthotonus (HP:0002179)1.84499473
74Supranuclear gaze palsy (HP:0000605)1.81879650
75Glomerulosclerosis (HP:0000096)1.80677432
76Hypoplastic iliac wings (HP:0002866)1.80647963
77Adactyly (HP:0009776)1.80033899
78Tachypnea (HP:0002789)1.78838359
79Megalocornea (HP:0000485)1.78307350
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78108865
81Absent epiphyses (HP:0010577)1.78108865
82Osteoarthritis (HP:0002758)1.77333562
83Stage 5 chronic kidney disease (HP:0003774)1.76870652
84Multifactorial inheritance (HP:0001426)1.76358278
85Progressive cerebellar ataxia (HP:0002073)1.74203074
86Abnormality of nucleobase metabolism (HP:0010932)1.73136152
87Akinesia (HP:0002304)1.72141985
88Absence seizures (HP:0002121)1.68955398
89Hematuria (HP:0000790)1.68730198
90Type I diabetes mellitus (HP:0100651)1.65633185
91Slow saccadic eye movements (HP:0000514)1.62015645
92Absent hand (HP:0004050)1.61327908
93Broad distal phalanx of finger (HP:0009836)1.61067256
94Oligodactyly (hands) (HP:0001180)1.60547144
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58739606
96Recurrent skin infections (HP:0001581)1.58647945
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.57540748
98Bowing of the arm (HP:0006488)1.56984577
99Bowed forearm bones (HP:0003956)1.56984577
100Nonprogressive disorder (HP:0003680)1.55508104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.81322349
2TRIB35.79104485
3MAPK153.76402723
4CSF1R3.29925524
5EPHA43.23929515
6WNK42.88250632
7PTK62.85045589
8RIPK12.77860813
9TLK12.68301983
10JAK12.24454710
11TYK22.10414660
12IKBKE2.00846552
13EPHA31.78616527
14NTRK11.74195494
15CLK11.70577220
16MAP2K21.70464788
17PAK31.70237565
18FGFR21.52480675
19SIK21.49833032
20CAMK11.48940340
21FES1.47022013
22NTRK21.44619326
23MAP3K141.34549889
24STK391.32116766
25PAK61.30917720
26ERN11.24619210
27OXSR11.22776125
28ZAK1.21470043
29NEK21.11892326
30SYK1.10745635
31TBK11.05729382
32GRK61.04783960
33GRK71.03258219
34PDK11.01021946
35ADRBK21.00808654
36CAMK40.93999564
37EPHA20.93101017
38PKN10.90291267
39AKT30.90107960
40TIE10.87754227
41DYRK1B0.82976812
42PRKCI0.82020286
43HCK0.80883112
44LIMK10.76811583
45ZAP700.76375020
46MKNK20.76150068
47FGR0.72626478
48PIM10.70760534
49DAPK20.69180120
50IGF1R0.66132925
51PDPK10.64613388
52MAP3K110.64518968
53CSNK1A10.62016546
54KSR10.61856025
55ILK0.61519761
56DMPK0.60247022
57FGFR40.57934268
58PTK2B0.54722798
59PRKD20.52858276
60TNK20.51523303
61INSR0.50928304
62GSK3A0.50927211
63GRK10.50926179
64CAMK2A0.49097545
65PRKCQ0.48202963
66CDK70.47692333
67JAK30.47595797
68PRKCH0.47472885
69JAK20.46777211
70PRKCG0.45855596
71CSNK1D0.45396656
72WNK10.44778613
73BTK0.43860764
74STK40.43690569
75MARK10.43144546
76MARK30.41124400
77PHKG10.40770148
78PHKG20.40770148
79PDGFRB0.40324871
80LCK0.37644520
81EIF2AK20.37434525
82ERBB20.35631003
83MAP2K10.35297877
84KIT0.35180227
85MAPK100.34700594
86MAP3K50.34599833
87PRKD30.33680016
88CAMKK10.33022832
89LYN0.31498536
90NME10.30142225
91MARK20.29106746
92CAMKK20.28854595
93PRKCA0.27432066
94NTRK30.26594791
95CAMK2B0.26331867
96PRKAA20.25712822
97MAPK30.25414604
98SRC0.25199655
99PRKCZ0.24237035
100ACVR1B0.23731893

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.13870696
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.64104421
3Linoleic acid metabolism_Homo sapiens_hsa005913.48449234
4* Salivary secretion_Homo sapiens_hsa049703.22274291
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.78409127
6African trypanosomiasis_Homo sapiens_hsa051432.55742667
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.53247005
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.50478615
9Ether lipid metabolism_Homo sapiens_hsa005652.39978831
10Cocaine addiction_Homo sapiens_hsa050302.13540452
11Amphetamine addiction_Homo sapiens_hsa050312.12585976
12Circadian entrainment_Homo sapiens_hsa047131.86423206
13Arachidonic acid metabolism_Homo sapiens_hsa005901.84930346
14Primary immunodeficiency_Homo sapiens_hsa053401.78459209
15Phototransduction_Homo sapiens_hsa047441.67366323
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66918054
17Hepatitis C_Homo sapiens_hsa051601.65985660
18Arginine biosynthesis_Homo sapiens_hsa002201.59174758
19Other glycan degradation_Homo sapiens_hsa005111.51099871
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47112335
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46370883
22Nicotine addiction_Homo sapiens_hsa050331.46084590
23Morphine addiction_Homo sapiens_hsa050321.40216697
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37250012
25Tight junction_Homo sapiens_hsa045301.32639580
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.32179060
27Synaptic vesicle cycle_Homo sapiens_hsa047211.26190703
28Ovarian steroidogenesis_Homo sapiens_hsa049131.25532667
29Thyroid hormone synthesis_Homo sapiens_hsa049181.17015012
30RNA polymerase_Homo sapiens_hsa030201.16740853
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13124680
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.06742706
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.05857212
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.05295328
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05152603
36Serotonergic synapse_Homo sapiens_hsa047261.04499015
37Long-term potentiation_Homo sapiens_hsa047201.03079082
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.00070627
39Insulin secretion_Homo sapiens_hsa049110.98654985
40TNF signaling pathway_Homo sapiens_hsa046680.94350013
41Glutamatergic synapse_Homo sapiens_hsa047240.93306772
42VEGF signaling pathway_Homo sapiens_hsa043700.90335858
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88285852
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86764829
45Cholinergic synapse_Homo sapiens_hsa047250.82974380
46Glycerolipid metabolism_Homo sapiens_hsa005610.82930123
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82419441
48Estrogen signaling pathway_Homo sapiens_hsa049150.82314300
49MAPK signaling pathway_Homo sapiens_hsa040100.80202783
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77894949
51Long-term depression_Homo sapiens_hsa047300.76328695
52Taste transduction_Homo sapiens_hsa047420.75435345
53T cell receptor signaling pathway_Homo sapiens_hsa046600.73940426
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73505673
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.73157292
56Gastric acid secretion_Homo sapiens_hsa049710.70750667
57Ras signaling pathway_Homo sapiens_hsa040140.70436048
58Calcium signaling pathway_Homo sapiens_hsa040200.68467272
59Choline metabolism in cancer_Homo sapiens_hsa052310.68148916
60Vitamin B6 metabolism_Homo sapiens_hsa007500.67387457
61Selenocompound metabolism_Homo sapiens_hsa004500.66563982
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66371267
63Hepatitis B_Homo sapiens_hsa051610.65108268
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63492613
65GnRH signaling pathway_Homo sapiens_hsa049120.63307078
66Dopaminergic synapse_Homo sapiens_hsa047280.61756521
67Nitrogen metabolism_Homo sapiens_hsa009100.61597948
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.58975899
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.55217017
70Osteoclast differentiation_Homo sapiens_hsa043800.53134698
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52655741
72One carbon pool by folate_Homo sapiens_hsa006700.50418240
73cAMP signaling pathway_Homo sapiens_hsa040240.49397910
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49291469
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48452969
76Olfactory transduction_Homo sapiens_hsa047400.47618549
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46292477
78Pyruvate metabolism_Homo sapiens_hsa006200.45967476
79Oxytocin signaling pathway_Homo sapiens_hsa049210.45964184
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45610641
81Fat digestion and absorption_Homo sapiens_hsa049750.45325246
82Tryptophan metabolism_Homo sapiens_hsa003800.44674883
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44459451
84Hedgehog signaling pathway_Homo sapiens_hsa043400.43232988
85GABAergic synapse_Homo sapiens_hsa047270.42172814
86Arginine and proline metabolism_Homo sapiens_hsa003300.41433368
87Protein digestion and absorption_Homo sapiens_hsa049740.40339116
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40015099
89Lysine degradation_Homo sapiens_hsa003100.38982928
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32828960
91Measles_Homo sapiens_hsa051620.32776730
92Homologous recombination_Homo sapiens_hsa034400.32579497
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32324443
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32099465
95Renin secretion_Homo sapiens_hsa049240.30753377
96Small cell lung cancer_Homo sapiens_hsa052220.29067393
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28080685
98B cell receptor signaling pathway_Homo sapiens_hsa046620.27284944
99ECM-receptor interaction_Homo sapiens_hsa045120.23773272
100Non-small cell lung cancer_Homo sapiens_hsa052230.23484601

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