Rank | Gene Set | Z-score |
---|---|---|
1 | response to pheromone (GO:0019236) | 9.91094391 |
2 | fusion of sperm to egg plasma membrane (GO:0007342) | 9.77190124 |
3 | chromosome condensation (GO:0030261) | 9.37851300 |
4 | DNA packaging (GO:0006323) | 8.83969458 |
5 | single strand break repair (GO:0000012) | 8.28424341 |
6 | spermatid nucleus differentiation (GO:0007289) | 7.99243493 |
7 | sperm capacitation (GO:0048240) | 7.97835277 |
8 | spermatid development (GO:0007286) | 7.62966683 |
9 | plasma membrane fusion (GO:0045026) | 7.28983797 |
10 | sperm-egg recognition (GO:0035036) | 7.20218346 |
11 | microtubule depolymerization (GO:0007019) | 7.17939875 |
12 | protein targeting to Golgi (GO:0000042) | 6.74345073 |
13 | binding of sperm to zona pellucida (GO:0007339) | 6.66053215 |
14 | multicellular organism reproduction (GO:0032504) | 6.62017817 |
15 | rRNA methylation (GO:0031167) | 6.53980216 |
16 | sexual reproduction (GO:0019953) | 6.52094501 |
17 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 6.47002695 |
18 | establishment of protein localization to Golgi (GO:0072600) | 6.45802622 |
19 | reproduction (GO:0000003) | 6.36020943 |
20 | microtubule polymerization or depolymerization (GO:0031109) | 6.28113033 |
21 | rRNA modification (GO:0000154) | 5.97738065 |
22 | cell-cell recognition (GO:0009988) | 5.89421704 |
23 | spermatogenesis (GO:0007283) | 5.62314958 |
24 | protein polyglutamylation (GO:0018095) | 5.61418203 |
25 | male gamete generation (GO:0048232) | 5.60320675 |
26 | calcium ion-dependent exocytosis (GO:0017156) | 5.58505774 |
27 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.40904821 |
28 | positive regulation of Rab GTPase activity (GO:0032851) | 5.40127359 |
29 | regulation of Rab GTPase activity (GO:0032313) | 5.40127359 |
30 | axonemal dynein complex assembly (GO:0070286) | 5.32196657 |
31 | gamete generation (GO:0007276) | 5.13884462 |
32 | negative regulation of inclusion body assembly (GO:0090084) | 5.03514634 |
33 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.99072260 |
34 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.81212225 |
35 | single fertilization (GO:0007338) | 4.70249253 |
36 | centriole replication (GO:0007099) | 4.63225672 |
37 | protein localization to Golgi apparatus (GO:0034067) | 4.62911240 |
38 | regulation of centriole replication (GO:0046599) | 4.53201111 |
39 | chromatin silencing (GO:0006342) | 4.41927590 |
40 | germ cell development (GO:0007281) | 4.37807955 |
41 | cellular ketone body metabolic process (GO:0046950) | 4.28857684 |
42 | regulation of cilium movement (GO:0003352) | 4.24397676 |
43 | centriole assembly (GO:0098534) | 4.14337321 |
44 | motile cilium assembly (GO:0044458) | 4.11059201 |
45 | multicellular organismal reproductive process (GO:0048609) | 4.11033758 |
46 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 4.08948877 |
47 | RNA destabilization (GO:0050779) | 4.07248586 |
48 | nucleus organization (GO:0006997) | 4.04967324 |
49 | microtubule severing (GO:0051013) | 4.02827575 |
50 | seminiferous tubule development (GO:0072520) | 3.97342675 |
51 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.96720885 |
52 | regulation of transcription involved in cell fate commitment (GO:0060850) | 3.95300600 |
53 | protein-DNA complex disassembly (GO:0032986) | 3.92863757 |
54 | nucleosome disassembly (GO:0006337) | 3.92863757 |
55 | fertilization (GO:0009566) | 3.88190417 |
56 | mesonephros development (GO:0001823) | 3.85785036 |
57 | peptidyl-threonine dephosphorylation (GO:0035970) | 3.84773813 |
58 | positive regulation of endothelial cell differentiation (GO:0045603) | 3.83795040 |
59 | response to acidic pH (GO:0010447) | 3.77689032 |
60 | regulation of inclusion body assembly (GO:0090083) | 3.74259281 |
61 | ketone body metabolic process (GO:1902224) | 3.73346698 |
62 | multicellular organismal movement (GO:0050879) | 3.53430434 |
63 | musculoskeletal movement (GO:0050881) | 3.53430434 |
64 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.50792890 |
65 | coenzyme catabolic process (GO:0009109) | 3.48231039 |
66 | ribosome assembly (GO:0042255) | 3.46601815 |
67 | microtubule nucleation (GO:0007020) | 3.40460368 |
68 | glomerular visceral epithelial cell development (GO:0072015) | 3.36733985 |
69 | epithelial cilium movement (GO:0003351) | 3.36021551 |
70 | negative regulation of gene silencing (GO:0060969) | 3.34829346 |
71 | polyamine biosynthetic process (GO:0006596) | 3.33924289 |
72 | DNA conformation change (GO:0071103) | 3.24737930 |
73 | glomerular epithelial cell development (GO:0072310) | 3.24025376 |
74 | histone exchange (GO:0043486) | 3.23866104 |
75 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.23339912 |
76 | glycerol ether metabolic process (GO:0006662) | 3.19653320 |
77 | negative regulation of gene expression, epigenetic (GO:0045814) | 3.19386626 |
78 | organic cation transport (GO:0015695) | 3.17128437 |
79 | establishment of apical/basal cell polarity (GO:0035089) | 3.13183311 |
80 | negative regulation of histone methylation (GO:0031061) | 3.10210538 |
81 | cilium movement (GO:0003341) | 3.09029866 |
82 | intra-Golgi vesicle-mediated transport (GO:0006891) | 3.07935818 |
83 | cellular response to pH (GO:0071467) | 3.04776956 |
84 | regulation of endothelial cell differentiation (GO:0045601) | 2.96817701 |
85 | cell wall macromolecule metabolic process (GO:0044036) | 2.95427769 |
86 | tRNA methylation (GO:0030488) | 2.94629372 |
87 | ether metabolic process (GO:0018904) | 2.91212186 |
88 | positive regulation of T cell differentiation in thymus (GO:0033089) | 2.90439039 |
89 | cell wall macromolecule catabolic process (GO:0016998) | 2.84979597 |
90 | cell recognition (GO:0008037) | 2.83824652 |
91 | regulation of interleukin-13 production (GO:0032656) | 2.82372752 |
92 | tachykinin receptor signaling pathway (GO:0007217) | 2.80090454 |
93 | multicellular organismal development (GO:0007275) | 2.75234003 |
94 | regulation of ARF GTPase activity (GO:0032312) | 2.73663929 |
95 | dendritic cell chemotaxis (GO:0002407) | 2.70777290 |
96 | nuclear pore complex assembly (GO:0051292) | 2.64814981 |
97 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.64669130 |
98 | establishment of monopolar cell polarity (GO:0061162) | 2.64669130 |
99 | acrosome reaction (GO:0007340) | 10.8031158 |
100 | sperm motility (GO:0030317) | 10.4805061 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 5.49638941 |
2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.37746764 |
3 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.25557675 |
4 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 3.19121017 |
5 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.53682943 |
6 | ERA_21632823_ChIP-Seq_H3396_Human | 2.34370927 |
7 | RAC3_21632823_ChIP-Seq_H3396_Human | 2.32210768 |
8 | FUS_26573619_Chip-Seq_HEK293_Human | 2.26145689 |
9 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 2.21412001 |
10 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.21412001 |
11 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 2.20048168 |
12 | CBP_20019798_ChIP-Seq_JUKART_Human | 2.20048168 |
13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.19520347 |
14 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 2.10700307 |
15 | NANOG_20526341_ChIP-Seq_ESCs_Human | 2.06865406 |
16 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.04550467 |
17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.03774092 |
18 | CTCF_27219007_Chip-Seq_Bcells_Human | 2.02912185 |
19 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 2.02843306 |
20 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 2.00613409 |
21 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.95810986 |
22 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.93966041 |
23 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.90206033 |
24 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.86273825 |
25 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.84937806 |
26 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.81888695 |
27 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.81413988 |
28 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.80894061 |
29 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.76360105 |
30 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.76240122 |
31 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.74533246 |
32 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.74505626 |
33 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.68347687 |
34 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.67507530 |
35 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.66965766 |
36 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.64840028 |
37 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.61448199 |
38 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.60040451 |
39 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.59167557 |
40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.57150026 |
41 | P68_20966046_ChIP-Seq_HELA_Human | 1.55741640 |
42 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.53342312 |
43 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.47184230 |
44 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.46912217 |
45 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.46778130 |
46 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.46206708 |
47 | P300_27268052_Chip-Seq_Bcells_Human | 1.44297860 |
48 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.44283571 |
49 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.44245437 |
50 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.41754185 |
51 | P300_19829295_ChIP-Seq_ESCs_Human | 1.41706053 |
52 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.40893530 |
53 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.40736170 |
54 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.40578455 |
55 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.40143254 |
56 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.38955974 |
57 | AR_25329375_ChIP-Seq_VCAP_Human | 1.38609936 |
58 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.37026040 |
59 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.37008815 |
60 | SA1_27219007_Chip-Seq_Bcells_Human | 1.35344461 |
61 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.35247918 |
62 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.34912026 |
63 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.34370896 |
64 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.33693722 |
65 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.32640060 |
66 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.31983137 |
67 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.26390704 |
68 | TBL1_22424771_ChIP-Seq_293T_Human | 1.26036119 |
69 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.24789409 |
70 | E2F1_17053090_ChIP-ChIP_MCF-7_Human | 1.24483535 |
71 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.22196648 |
72 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.21808668 |
73 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.20510503 |
74 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.19601882 |
75 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.18894407 |
76 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.18707647 |
77 | NFYB_21822215_ChIP-Seq_K562_Human | 1.17142548 |
78 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.17130229 |
79 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.17127662 |
80 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.14217591 |
81 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.13963189 |
82 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.12396365 |
83 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10326531 |
84 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.08296484 |
85 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.06810024 |
86 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.05593196 |
87 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.04694195 |
88 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.04273936 |
89 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.04083656 |
90 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.03698003 |
91 | NFYA_21822215_ChIP-Seq_K562_Human | 1.03051516 |
92 | SOX2_21211035_ChIP-Seq_LN229_Human | 1.03049143 |
93 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 1.02811113 |
94 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.02651195 |
95 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.02589756 |
96 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.02497382 |
97 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.01228876 |
98 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.01021589 |
99 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00678599 |
100 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00412306 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005377_hearing/vestibular/ear_phenot | 5.23108958 |
2 | MP0003878_abnormal_ear_physiology | 5.23108958 |
3 | MP0005670_abnormal_white_adipose | 4.20870788 |
4 | MP0003698_abnormal_male_reproductive | 4.01961004 |
5 | MP0001929_abnormal_gametogenesis | 3.61550583 |
6 | MP0001348_abnormal_lacrimal_gland | 3.58257120 |
7 | MP0003011_delayed_dark_adaptation | 2.79548367 |
8 | MP0003718_maternal_effect | 2.37051147 |
9 | MP0002161_abnormal_fertility/fecundity | 2.26071459 |
10 | MP0002254_reproductive_system_inflammat | 2.10516176 |
11 | MP0002132_abnormal_respiratory_system | 2.01294346 |
12 | MP0005410_abnormal_fertilization | 10.6667976 |
13 | MP0000678_abnormal_parathyroid_gland | 1.93209445 |
14 | MP0002210_abnormal_sex_determination | 1.79480757 |
15 | MP0005310_abnormal_salivary_gland | 1.73541728 |
16 | MP0001145_abnormal_male_reproductive | 1.57717287 |
17 | MP0001968_abnormal_touch/_nociception | 1.57146075 |
18 | MP0003646_muscle_fatigue | 1.53046597 |
19 | MP0002249_abnormal_larynx_morphology | 1.46261902 |
20 | MP0000653_abnormal_sex_gland | 1.46074177 |
21 | MP0008995_early_reproductive_senescence | 1.43663619 |
22 | MP0005379_endocrine/exocrine_gland_phen | 1.42516533 |
23 | MP0002127_abnormal_cardiovascular_syste | 1.42271843 |
24 | MP0002822_catalepsy | 1.32263013 |
25 | MP0001485_abnormal_pinna_reflex | 1.29991748 |
26 | MP0002736_abnormal_nociception_after | 1.28110090 |
27 | MP0001486_abnormal_startle_reflex | 1.25099834 |
28 | MP0008877_abnormal_DNA_methylation | 1.23920396 |
29 | MP0000566_synostosis | 1.23605605 |
30 | MP0002653_abnormal_ependyma_morphology | 1.22219747 |
31 | MP0003880_abnormal_central_pattern | 1.21292129 |
32 | MP0002282_abnormal_trachea_morphology | 1.14631719 |
33 | MP0004264_abnormal_extraembryonic_tissu | 1.13676131 |
34 | MP0006292_abnormal_olfactory_placode | 1.13283623 |
35 | MP0003077_abnormal_cell_cycle | 1.11172845 |
36 | MP0009053_abnormal_anal_canal | 1.11061903 |
37 | MP0000534_abnormal_ureter_morphology | 1.10415783 |
38 | MP0001963_abnormal_hearing_physiology | 1.09547743 |
39 | MP0005253_abnormal_eye_physiology | 1.06693763 |
40 | MP0003941_abnormal_skin_development | 1.02905969 |
41 | MP0004957_abnormal_blastocyst_morpholog | 1.01252268 |
42 | MP0000049_abnormal_middle_ear | 1.00107008 |
43 | MP0001765_abnormal_ion_homeostasis | 0.99915608 |
44 | MP0000026_abnormal_inner_ear | 0.99392520 |
45 | MP0002735_abnormal_chemical_nociception | 0.93609082 |
46 | MP0003111_abnormal_nucleus_morphology | 0.88455295 |
47 | MP0002234_abnormal_pharynx_morphology | 0.84760027 |
48 | MP0004782_abnormal_surfactant_physiolog | 0.81964187 |
49 | MP0005167_abnormal_blood-brain_barrier | 0.81546449 |
50 | MP0003119_abnormal_digestive_system | 0.81085299 |
51 | MP0005248_abnormal_Harderian_gland | 0.80983959 |
52 | MP0008789_abnormal_olfactory_epithelium | 0.80694421 |
53 | MP0003693_abnormal_embryo_hatching | 0.80656554 |
54 | MP0005395_other_phenotype | 0.79412242 |
55 | MP0002229_neurodegeneration | 0.79092522 |
56 | MP0005423_abnormal_somatic_nervous | 0.78387426 |
57 | MP0001529_abnormal_vocalization | 0.77956943 |
58 | MP0000470_abnormal_stomach_morphology | 0.76403672 |
59 | MP0009697_abnormal_copulation | 0.75745044 |
60 | MP0005666_abnormal_adipose_tissue | 0.72171081 |
61 | MP0005499_abnormal_olfactory_system | 0.69490003 |
62 | MP0005394_taste/olfaction_phenotype | 0.69490003 |
63 | MP0005551_abnormal_eye_electrophysiolog | 0.69415002 |
64 | MP0001293_anophthalmia | 0.69138810 |
65 | MP0001984_abnormal_olfaction | 0.67473447 |
66 | MP0004742_abnormal_vestibular_system | 0.66373696 |
67 | MP0001346_abnormal_lacrimal_gland | 0.66266243 |
68 | MP0000613_abnormal_salivary_gland | 0.64800708 |
69 | MP0010094_abnormal_chromosome_stability | 0.64124636 |
70 | MP0000955_abnormal_spinal_cord | 0.62752550 |
71 | MP0003937_abnormal_limbs/digits/tail_de | 0.62567359 |
72 | MP0002557_abnormal_social/conspecific_i | 0.62256213 |
73 | MP0004085_abnormal_heartbeat | 0.59167303 |
74 | MP0001501_abnormal_sleep_pattern | 0.58324444 |
75 | MP0002933_joint_inflammation | 0.57063115 |
76 | MP0005391_vision/eye_phenotype | 0.53895556 |
77 | MP0004233_abnormal_muscle_weight | 0.53587953 |
78 | MP0002733_abnormal_thermal_nociception | 0.53142249 |
79 | MP0001286_abnormal_eye_development | 0.52366121 |
80 | MP0003699_abnormal_female_reproductive | 0.51336062 |
81 | MP0001905_abnormal_dopamine_level | 0.50742779 |
82 | MP0003638_abnormal_response/metabolism_ | 0.49365458 |
83 | MP0001119_abnormal_female_reproductive | 0.48375530 |
84 | MP0005451_abnormal_body_composition | 0.48224416 |
85 | MP0005332_abnormal_amino_acid | 0.48177207 |
86 | MP0004859_abnormal_synaptic_plasticity | 0.48153572 |
87 | MP0003329_amyloid_beta_deposits | 0.48081716 |
88 | MP0002085_abnormal_embryonic_tissue | 0.47681526 |
89 | MP0008004_abnormal_stomach_pH | 0.46850676 |
90 | MP0001666_abnormal_nutrient_absorption | 0.46560928 |
91 | MP0005636_abnormal_mineral_homeostasis | 0.45954511 |
92 | MP0004133_heterotaxia | 0.45230411 |
93 | MP0008569_lethality_at_weaning | 0.45191586 |
94 | MP0005647_abnormal_sex_gland | 0.44889683 |
95 | MP0003861_abnormal_nervous_system | 0.44629738 |
96 | MP0005595_abnormal_vascular_smooth | 0.43727583 |
97 | MP0003879_abnormal_hair_cell | 0.43457901 |
98 | MP0008775_abnormal_heart_ventricle | 0.43438829 |
99 | MP0009115_abnormal_fat_cell | 0.42764042 |
100 | MP0005275_abnormal_skin_tensile | 0.41624208 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Severe visual impairment (HP:0001141) | 6.77414934 |
2 | Absent/shortened dynein arms (HP:0200106) | 4.91707415 |
3 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.91707415 |
4 | Infertility (HP:0000789) | 4.45908269 |
5 | Bony spicule pigmentary retinopathy (HP:0007737) | 4.39791148 |
6 | Hyperkalemia (HP:0002153) | 4.15047545 |
7 | Bell-shaped thorax (HP:0001591) | 4.13347524 |
8 | Asymmetric septal hypertrophy (HP:0001670) | 4.07796377 |
9 | Abnormal respiratory motile cilium physiology (HP:0012261) | 4.04279162 |
10 | Chronic hepatic failure (HP:0100626) | 3.99169478 |
11 | Attenuation of retinal blood vessels (HP:0007843) | 3.96699537 |
12 | Abnormal ciliary motility (HP:0012262) | 3.95212930 |
13 | Impulsivity (HP:0100710) | 3.88868464 |
14 | Resting tremor (HP:0002322) | 3.75580546 |
15 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.59852688 |
16 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.59852688 |
17 | Tubulointerstitial nephritis (HP:0001970) | 3.51391330 |
18 | Hypoplastic ischia (HP:0003175) | 3.48867496 |
19 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.45143121 |
20 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 3.41174215 |
21 | Male infertility (HP:0003251) | 3.20856298 |
22 | Esophageal atresia (HP:0002032) | 3.09491748 |
23 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.07344892 |
24 | Chronic bronchitis (HP:0004469) | 3.03822044 |
25 | Abnormal spermatogenesis (HP:0008669) | 3.01623537 |
26 | Abnormality of the aortic arch (HP:0012303) | 2.98343437 |
27 | Abnormality of the ischium (HP:0003174) | 2.96695834 |
28 | Cone-rod dystrophy (HP:0000548) | 2.84741697 |
29 | Abnormality of macular pigmentation (HP:0008002) | 2.83107754 |
30 | Double outlet right ventricle (HP:0001719) | 2.72662007 |
31 | Congenital malformation of the right heart (HP:0011723) | 2.72662007 |
32 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.72486146 |
33 | Enlarged epiphyses (HP:0010580) | 2.72025239 |
34 | Absent epiphyses (HP:0010577) | 2.71646881 |
35 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.71646881 |
36 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.70114956 |
37 | Hypoplasia of the thymus (HP:0000778) | 2.69848586 |
38 | Progressive sensorineural hearing impairment (HP:0000408) | 2.63584502 |
39 | Renal dysplasia (HP:0000110) | 2.61272696 |
40 | Potter facies (HP:0002009) | 2.59237005 |
41 | Facial shape deformation (HP:0011334) | 2.59237005 |
42 | Nasal polyposis (HP:0100582) | 2.57455063 |
43 | Muscle fiber atrophy (HP:0100295) | 2.53917205 |
44 | Postural instability (HP:0002172) | 2.53749884 |
45 | Nephronophthisis (HP:0000090) | 2.50846038 |
46 | Amelogenesis imperfecta (HP:0000705) | 2.47837798 |
47 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 2.47611565 |
48 | Myokymia (HP:0002411) | 2.41608313 |
49 | Azoospermia (HP:0000027) | 2.40277082 |
50 | Absent thumb (HP:0009777) | 2.37304991 |
51 | Rhinitis (HP:0012384) | 2.32820061 |
52 | Supernumerary ribs (HP:0005815) | 2.32312869 |
53 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 2.31904422 |
54 | Abnormality of femoral epiphyses (HP:0006499) | 2.31904422 |
55 | Abnormality of the costochondral junction (HP:0000919) | 2.24427873 |
56 | Abnormality of the femoral head (HP:0003368) | 2.22388271 |
57 | Optic nerve hypoplasia (HP:0000609) | 2.20796788 |
58 | Truncal obesity (HP:0001956) | 2.19639177 |
59 | Stage 5 chronic kidney disease (HP:0003774) | 2.17629909 |
60 | Abnormal urine output (HP:0012590) | 2.17209362 |
61 | Epiphyseal dysplasia (HP:0002656) | 2.16016871 |
62 | Abnormality of potassium homeostasis (HP:0011042) | 2.11063345 |
63 | Gastrointestinal atresia (HP:0002589) | 2.10771760 |
64 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.10098002 |
65 | Progressive cerebellar ataxia (HP:0002073) | 2.09624811 |
66 | Type 2 muscle fiber atrophy (HP:0003554) | 2.08722935 |
67 | Short tibia (HP:0005736) | 2.08463088 |
68 | Cerebellar dysplasia (HP:0007033) | 2.06974477 |
69 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.06765036 |
70 | Abnormality of dental color (HP:0011073) | 2.06650897 |
71 | Flattened epiphyses (HP:0003071) | 2.06232825 |
72 | Anterior segment dysgenesis (HP:0007700) | 2.06200978 |
73 | Abnormality of the renal medulla (HP:0100957) | 2.03854100 |
74 | Mixed hearing impairment (HP:0000410) | 2.02834296 |
75 | Abdominal situs inversus (HP:0003363) | 2.02482637 |
76 | Abnormality of abdominal situs (HP:0011620) | 2.02482637 |
77 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.02470783 |
78 | Fibular hypoplasia (HP:0003038) | 2.01658047 |
79 | Abnormality of chloride homeostasis (HP:0011422) | 1.96947439 |
80 | Abnormality of the pubic bones (HP:0003172) | 1.95608785 |
81 | Bronchiectasis (HP:0002110) | 1.95244306 |
82 | Stereotypic behavior (HP:0000733) | 1.93384331 |
83 | Retinal dysplasia (HP:0007973) | 1.92492232 |
84 | Occipital encephalocele (HP:0002085) | 1.92289040 |
85 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.91419728 |
86 | Abnormality of the nasal mucosa (HP:0000433) | 1.87661637 |
87 | Respiratory distress (HP:0002098) | 1.84511839 |
88 | Abnormality of DNA repair (HP:0003254) | 1.83317682 |
89 | Intellectual disability, moderate (HP:0002342) | 1.82698977 |
90 | Abnormality of renal excretion (HP:0011036) | 1.82624849 |
91 | Vertebral clefting (HP:0008428) | 1.80961427 |
92 | Polyuria (HP:0000103) | 1.79371169 |
93 | Abnormality of the parathyroid morphology (HP:0011766) | 1.79184512 |
94 | Long foot (HP:0001833) | 1.78687163 |
95 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.76531568 |
96 | Flat capital femoral epiphysis (HP:0003370) | 1.76486996 |
97 | Hyponatremia (HP:0002902) | 1.75190025 |
98 | Type I transferrin isoform profile (HP:0003642) | 1.75034301 |
99 | Osteomalacia (HP:0002749) | 1.72756956 |
100 | Portal hypertension (HP:0001409) | 1.72506248 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PLK4 | 7.65491979 |
2 | TAOK3 | 5.18500339 |
3 | TESK1 | 4.91380547 |
4 | DDR2 | 3.86645310 |
5 | INSRR | 3.46645310 |
6 | BRD4 | 2.88549933 |
7 | MAP4K2 | 2.57471645 |
8 | CAMK1G | 2.46450562 |
9 | PLK2 | 2.39794990 |
10 | ZAK | 2.36394402 |
11 | MST1R | 2.14424796 |
12 | MAP2K2 | 2.13966654 |
13 | MAPK15 | 2.11403063 |
14 | STK38 | 2.09854902 |
15 | PNCK | 1.95993197 |
16 | STK38L | 1.87690663 |
17 | GRK5 | 1.82530698 |
18 | CDC7 | 1.65755645 |
19 | CAMK1D | 1.47320418 |
20 | PRKD3 | 1.46963550 |
21 | GRK6 | 1.39829853 |
22 | CDK12 | 1.37409250 |
23 | CDK7 | 1.36241812 |
24 | WNK1 | 1.26575749 |
25 | MAPKAPK3 | 1.18383113 |
26 | DYRK1B | 1.14058243 |
27 | PDK1 | 0.98378898 |
28 | PDPK1 | 0.97459139 |
29 | PRKG2 | 0.94654541 |
30 | WNK4 | 0.89265489 |
31 | CDK19 | 0.88048425 |
32 | PIK3CG | 0.88044023 |
33 | PTK2B | 0.87695600 |
34 | SRPK1 | 0.83400315 |
35 | TIE1 | 0.75804535 |
36 | RPS6KA1 | 0.75446563 |
37 | STK16 | 0.75444961 |
38 | EPHA4 | 0.74844796 |
39 | RPS6KA4 | 0.74705929 |
40 | RPS6KA2 | 0.71352522 |
41 | NEK6 | 0.67321973 |
42 | IRAK2 | 0.66356454 |
43 | MAP3K11 | 0.64223001 |
44 | NEK2 | 0.63786599 |
45 | OXSR1 | 0.63184404 |
46 | CAMK1 | 0.62980275 |
47 | CDK2 | 0.62801413 |
48 | TYRO3 | 0.57777787 |
49 | CHEK1 | 0.57356005 |
50 | EEF2K | 0.56118933 |
51 | BRSK1 | 0.55658417 |
52 | DYRK3 | 0.54776820 |
53 | PIM1 | 0.54767898 |
54 | CDK1 | 0.52879213 |
55 | PLK1 | 0.52875492 |
56 | ATR | 0.52731037 |
57 | PRKG1 | 0.50988599 |
58 | PASK | 0.49129716 |
59 | CHEK2 | 0.48381447 |
60 | LATS2 | 0.47914914 |
61 | DYRK2 | 0.47282079 |
62 | AURKA | 0.46771408 |
63 | MTOR | 0.45554159 |
64 | MAPK1 | 0.43825397 |
65 | PRKAA2 | 0.43722260 |
66 | UHMK1 | 0.43030798 |
67 | TESK2 | 0.40928483 |
68 | CDK3 | 0.40500309 |
69 | GSK3B | 0.40447813 |
70 | STK39 | 0.40343183 |
71 | CDK4 | 0.39432115 |
72 | MET | 0.38800597 |
73 | FGFR2 | 0.37808153 |
74 | RPS6KC1 | 0.37371006 |
75 | RPS6KL1 | 0.37371006 |
76 | MUSK | 0.34764817 |
77 | BMX | 0.33259301 |
78 | RPS6KA6 | 0.33083697 |
79 | MAPK14 | 0.32845665 |
80 | CAMK4 | 0.31040280 |
81 | FGFR1 | 0.29785662 |
82 | PRKCG | 0.27602192 |
83 | RIPK1 | 0.27593781 |
84 | SIK2 | 0.27524182 |
85 | MAP3K8 | 0.26797586 |
86 | NUAK1 | 0.26553541 |
87 | ATM | 0.26164686 |
88 | IKBKB | 0.26040859 |
89 | NME1 | 0.25479130 |
90 | TNK2 | 0.24391407 |
91 | ROCK1 | 0.23686707 |
92 | PRKCZ | 0.23492426 |
93 | AKT3 | 0.22448883 |
94 | ADRBK2 | 0.21791334 |
95 | BRSK2 | 0.21066197 |
96 | CSF1R | 0.20695554 |
97 | MAPK8 | 0.19537389 |
98 | PRKCB | 0.19394040 |
99 | CHUK | 0.17877233 |
100 | MAP2K1 | 0.17576654 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 6.65301499 |
2 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 4.43038153 |
3 | Selenocompound metabolism_Homo sapiens_hsa00450 | 3.35985814 |
4 | Olfactory transduction_Homo sapiens_hsa04740 | 3.31003349 |
5 | RNA transport_Homo sapiens_hsa03013 | 3.03581338 |
6 | Taste transduction_Homo sapiens_hsa04742 | 2.23952266 |
7 | Salivary secretion_Homo sapiens_hsa04970 | 2.10599327 |
8 | RNA polymerase_Homo sapiens_hsa03020 | 1.90664718 |
9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.73968194 |
10 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.70362037 |
11 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.53977230 |
12 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.50091710 |
13 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.49604631 |
14 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.36341295 |
15 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.35003198 |
16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.34470779 |
17 | DNA replication_Homo sapiens_hsa03030 | 1.33985175 |
18 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.33113452 |
19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.31873314 |
20 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.30765765 |
21 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.30131875 |
22 | RNA degradation_Homo sapiens_hsa03018 | 1.28276230 |
23 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.22547407 |
24 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.20845401 |
25 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.18027830 |
26 | Base excision repair_Homo sapiens_hsa03410 | 1.17983754 |
27 | Purine metabolism_Homo sapiens_hsa00230 | 1.17816963 |
28 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.16373627 |
29 | Retinol metabolism_Homo sapiens_hsa00830 | 1.12538054 |
30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.06221369 |
31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.06203267 |
32 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.01367093 |
33 | Spliceosome_Homo sapiens_hsa03040 | 1.01000411 |
34 | Endocytosis_Homo sapiens_hsa04144 | 0.96654051 |
35 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.95970014 |
36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.91672408 |
37 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.90789886 |
38 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.90228309 |
39 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.90136722 |
40 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.88243418 |
41 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.87861968 |
42 | Allograft rejection_Homo sapiens_hsa05330 | 0.81933350 |
43 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.80893270 |
44 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.79719183 |
45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.77880688 |
46 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.77498305 |
47 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.75934249 |
48 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.75606604 |
49 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.74587473 |
50 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.74366160 |
51 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.72371642 |
52 | Huntingtons disease_Homo sapiens_hsa05016 | 0.70479999 |
53 | Viral myocarditis_Homo sapiens_hsa05416 | 0.70383195 |
54 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.70307138 |
55 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.69469862 |
56 | Morphine addiction_Homo sapiens_hsa05032 | 0.68666044 |
57 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.68153918 |
58 | Lysine degradation_Homo sapiens_hsa00310 | 0.65048860 |
59 | Tight junction_Homo sapiens_hsa04530 | 0.64048146 |
60 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.63893413 |
61 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.61976411 |
62 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.60500119 |
63 | Adherens junction_Homo sapiens_hsa04520 | 0.59736207 |
64 | Nicotine addiction_Homo sapiens_hsa05033 | 0.59588711 |
65 | Sulfur relay system_Homo sapiens_hsa04122 | 0.59266454 |
66 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.58297490 |
67 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.56583016 |
68 | Renin secretion_Homo sapiens_hsa04924 | 0.56514170 |
69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.56163212 |
70 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.55414212 |
71 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.52387454 |
72 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.52139317 |
73 | Mismatch repair_Homo sapiens_hsa03430 | 0.50634595 |
74 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.48816135 |
75 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.48716864 |
76 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.45432250 |
77 | Phototransduction_Homo sapiens_hsa04744 | 0.45260752 |
78 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.43989804 |
79 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.43477865 |
80 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.41910110 |
81 | Homologous recombination_Homo sapiens_hsa03440 | 0.41561725 |
82 | ABC transporters_Homo sapiens_hsa02010 | 0.40851194 |
83 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.40579854 |
84 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.39941476 |
85 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.39934952 |
86 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.38066696 |
87 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.37281064 |
88 | Cell cycle_Homo sapiens_hsa04110 | 0.36946608 |
89 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.36334350 |
90 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.36085936 |
91 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.35946429 |
92 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.35837917 |
93 | Ribosome_Homo sapiens_hsa03010 | 0.35471372 |
94 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.35105923 |
95 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.34097558 |
96 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.32766333 |
97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.32271829 |
98 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.31739050 |
99 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.30824175 |
100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.29405724 |