PRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Long' allele. The protein isoforms encoded by this gene are recognized as the 'first line of oral defense' against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.91094391
2fusion of sperm to egg plasma membrane (GO:0007342)9.77190124
3chromosome condensation (GO:0030261)9.37851300
4DNA packaging (GO:0006323)8.83969458
5single strand break repair (GO:0000012)8.28424341
6spermatid nucleus differentiation (GO:0007289)7.99243493
7sperm capacitation (GO:0048240)7.97835277
8spermatid development (GO:0007286)7.62966683
9plasma membrane fusion (GO:0045026)7.28983797
10sperm-egg recognition (GO:0035036)7.20218346
11microtubule depolymerization (GO:0007019)7.17939875
12protein targeting to Golgi (GO:0000042)6.74345073
13binding of sperm to zona pellucida (GO:0007339)6.66053215
14multicellular organism reproduction (GO:0032504)6.62017817
15rRNA methylation (GO:0031167)6.53980216
16sexual reproduction (GO:0019953)6.52094501
17retrograde transport, vesicle recycling within Golgi (GO:0000301)6.47002695
18establishment of protein localization to Golgi (GO:0072600)6.45802622
19reproduction (GO:0000003)6.36020943
20microtubule polymerization or depolymerization (GO:0031109)6.28113033
21rRNA modification (GO:0000154)5.97738065
22cell-cell recognition (GO:0009988)5.89421704
23spermatogenesis (GO:0007283)5.62314958
24protein polyglutamylation (GO:0018095)5.61418203
25male gamete generation (GO:0048232)5.60320675
26calcium ion-dependent exocytosis (GO:0017156)5.58505774
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.40904821
28positive regulation of Rab GTPase activity (GO:0032851)5.40127359
29regulation of Rab GTPase activity (GO:0032313)5.40127359
30axonemal dynein complex assembly (GO:0070286)5.32196657
31gamete generation (GO:0007276)5.13884462
32negative regulation of inclusion body assembly (GO:0090084)5.03514634
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99072260
34phosphatidylethanolamine metabolic process (GO:0046337)4.81212225
35single fertilization (GO:0007338)4.70249253
36centriole replication (GO:0007099)4.63225672
37protein localization to Golgi apparatus (GO:0034067)4.62911240
38regulation of centriole replication (GO:0046599)4.53201111
39chromatin silencing (GO:0006342)4.41927590
40germ cell development (GO:0007281)4.37807955
41cellular ketone body metabolic process (GO:0046950)4.28857684
42regulation of cilium movement (GO:0003352)4.24397676
43centriole assembly (GO:0098534)4.14337321
44motile cilium assembly (GO:0044458)4.11059201
45multicellular organismal reproductive process (GO:0048609)4.11033758
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.08948877
47RNA destabilization (GO:0050779)4.07248586
48nucleus organization (GO:0006997)4.04967324
49microtubule severing (GO:0051013)4.02827575
50seminiferous tubule development (GO:0072520)3.97342675
51cilium or flagellum-dependent cell motility (GO:0001539)3.96720885
52regulation of transcription involved in cell fate commitment (GO:0060850)3.95300600
53protein-DNA complex disassembly (GO:0032986)3.92863757
54nucleosome disassembly (GO:0006337)3.92863757
55fertilization (GO:0009566)3.88190417
56mesonephros development (GO:0001823)3.85785036
57peptidyl-threonine dephosphorylation (GO:0035970)3.84773813
58positive regulation of endothelial cell differentiation (GO:0045603)3.83795040
59response to acidic pH (GO:0010447)3.77689032
60regulation of inclusion body assembly (GO:0090083)3.74259281
61ketone body metabolic process (GO:1902224)3.73346698
62multicellular organismal movement (GO:0050879)3.53430434
63musculoskeletal movement (GO:0050881)3.53430434
64negative regulation of Rho protein signal transduction (GO:0035024)3.50792890
65coenzyme catabolic process (GO:0009109)3.48231039
66ribosome assembly (GO:0042255)3.46601815
67microtubule nucleation (GO:0007020)3.40460368
68glomerular visceral epithelial cell development (GO:0072015)3.36733985
69epithelial cilium movement (GO:0003351)3.36021551
70negative regulation of gene silencing (GO:0060969)3.34829346
71polyamine biosynthetic process (GO:0006596)3.33924289
72DNA conformation change (GO:0071103)3.24737930
73glomerular epithelial cell development (GO:0072310)3.24025376
74histone exchange (GO:0043486)3.23866104
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.23339912
76glycerol ether metabolic process (GO:0006662)3.19653320
77negative regulation of gene expression, epigenetic (GO:0045814)3.19386626
78organic cation transport (GO:0015695)3.17128437
79establishment of apical/basal cell polarity (GO:0035089)3.13183311
80negative regulation of histone methylation (GO:0031061)3.10210538
81cilium movement (GO:0003341)3.09029866
82intra-Golgi vesicle-mediated transport (GO:0006891)3.07935818
83cellular response to pH (GO:0071467)3.04776956
84regulation of endothelial cell differentiation (GO:0045601)2.96817701
85cell wall macromolecule metabolic process (GO:0044036)2.95427769
86tRNA methylation (GO:0030488)2.94629372
87ether metabolic process (GO:0018904)2.91212186
88positive regulation of T cell differentiation in thymus (GO:0033089)2.90439039
89cell wall macromolecule catabolic process (GO:0016998)2.84979597
90cell recognition (GO:0008037)2.83824652
91regulation of interleukin-13 production (GO:0032656)2.82372752
92tachykinin receptor signaling pathway (GO:0007217)2.80090454
93multicellular organismal development (GO:0007275)2.75234003
94regulation of ARF GTPase activity (GO:0032312)2.73663929
95dendritic cell chemotaxis (GO:0002407)2.70777290
96nuclear pore complex assembly (GO:0051292)2.64814981
97establishment or maintenance of monopolar cell polarity (GO:0061339)2.64669130
98establishment of monopolar cell polarity (GO:0061162)2.64669130
99acrosome reaction (GO:0007340)10.8031158
100sperm motility (GO:0030317)10.4805061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.49638941
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.37746764
3EZH2_22144423_ChIP-Seq_EOC_Human3.25557675
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.19121017
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53682943
6ERA_21632823_ChIP-Seq_H3396_Human2.34370927
7RAC3_21632823_ChIP-Seq_H3396_Human2.32210768
8FUS_26573619_Chip-Seq_HEK293_Human2.26145689
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.21412001
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21412001
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.20048168
12CBP_20019798_ChIP-Seq_JUKART_Human2.20048168
13ZNF274_21170338_ChIP-Seq_K562_Hela2.19520347
14ELF1_20517297_ChIP-Seq_JURKAT_Human2.10700307
15NANOG_20526341_ChIP-Seq_ESCs_Human2.06865406
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04550467
17DROSHA_22980978_ChIP-Seq_HELA_Human2.03774092
18CTCF_27219007_Chip-Seq_Bcells_Human2.02912185
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.02843306
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human2.00613409
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.95810986
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93966041
23CTCF_20526341_ChIP-Seq_ESCs_Human1.90206033
24BCL6_27268052_Chip-Seq_Bcells_Human1.86273825
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84937806
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.81888695
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81413988
28E2F1_20622854_ChIP-Seq_HELA_Human1.80894061
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.76360105
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76240122
31PHF8_20622854_ChIP-Seq_HELA_Human1.74533246
32TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74505626
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.68347687
34MYC_19829295_ChIP-Seq_ESCs_Human1.67507530
35SMC4_20622854_ChIP-Seq_HELA_Human1.66965766
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.64840028
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61448199
38OCT4_20526341_ChIP-Seq_ESCs_Human1.60040451
39SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59167557
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57150026
41P68_20966046_ChIP-Seq_HELA_Human1.55741640
42BCOR_27268052_Chip-Seq_Bcells_Human1.53342312
43RBPJ_21746931_ChIP-Seq_IB4_Human1.47184230
44ER_23166858_ChIP-Seq_MCF-7_Human1.46912217
45P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.46778130
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.46206708
47P300_27268052_Chip-Seq_Bcells_Human1.44297860
48CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44283571
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.44245437
50SMAD3_21741376_ChIP-Seq_ESCs_Human1.41754185
51P300_19829295_ChIP-Seq_ESCs_Human1.41706053
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40893530
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.40736170
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40578455
55TP63_22573176_ChIP-Seq_HFKS_Human1.40143254
56P53_21459846_ChIP-Seq_SAOS-2_Human1.38955974
57AR_25329375_ChIP-Seq_VCAP_Human1.38609936
58HOXB7_26014856_ChIP-Seq_BT474_Human1.37026040
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37008815
60SA1_27219007_Chip-Seq_Bcells_Human1.35344461
61TAF2_19829295_ChIP-Seq_ESCs_Human1.35247918
62ETV1_20927104_ChIP-Seq_GIST48_Human1.34912026
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34370896
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33693722
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.32640060
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31983137
67CEBPB_22108803_ChIP-Seq_LS180_Human1.26390704
68TBL1_22424771_ChIP-Seq_293T_Human1.26036119
69FOXH1_21741376_ChIP-Seq_ESCs_Human1.24789409
70E2F1_17053090_ChIP-ChIP_MCF-7_Human1.24483535
71ERG_20517297_ChIP-Seq_VCAP_Human1.22196648
72PHF8_20622853_ChIP-Seq_HELA_Human1.21808668
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20510503
74SMAD4_21741376_ChIP-Seq_HESCs_Human1.19601882
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.18894407
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18707647
77NFYB_21822215_ChIP-Seq_K562_Human1.17142548
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.17130229
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17127662
80AR_21572438_ChIP-Seq_LNCaP_Human1.14217591
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13963189
82TP53_18474530_ChIP-ChIP_U2OS_Human1.12396365
83LXR_22292898_ChIP-Seq_THP-1_Human1.10326531
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08296484
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.06810024
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.05593196
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04694195
88E2F7_22180533_ChIP-Seq_HELA_Human1.04273936
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04083656
90RUNX2_22187159_ChIP-Seq_PCA_Human1.03698003
91NFYA_21822215_ChIP-Seq_K562_Human1.03051516
92SOX2_21211035_ChIP-Seq_LN229_Human1.03049143
93SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02811113
94RUNX_20019798_ChIP-Seq_JUKART_Human1.02651195
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02589756
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.02497382
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01228876
98CSB_26484114_Chip-Seq_FIBROBLAST_Human1.01021589
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00678599
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00412306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.23108958
2MP0003878_abnormal_ear_physiology5.23108958
3MP0005670_abnormal_white_adipose4.20870788
4MP0003698_abnormal_male_reproductive4.01961004
5MP0001929_abnormal_gametogenesis3.61550583
6MP0001348_abnormal_lacrimal_gland3.58257120
7MP0003011_delayed_dark_adaptation2.79548367
8MP0003718_maternal_effect2.37051147
9MP0002161_abnormal_fertility/fecundity2.26071459
10MP0002254_reproductive_system_inflammat2.10516176
11MP0002132_abnormal_respiratory_system2.01294346
12MP0005410_abnormal_fertilization10.6667976
13MP0000678_abnormal_parathyroid_gland1.93209445
14MP0002210_abnormal_sex_determination1.79480757
15MP0005310_abnormal_salivary_gland1.73541728
16MP0001145_abnormal_male_reproductive1.57717287
17MP0001968_abnormal_touch/_nociception1.57146075
18MP0003646_muscle_fatigue1.53046597
19MP0002249_abnormal_larynx_morphology1.46261902
20MP0000653_abnormal_sex_gland1.46074177
21MP0008995_early_reproductive_senescence1.43663619
22MP0005379_endocrine/exocrine_gland_phen1.42516533
23MP0002127_abnormal_cardiovascular_syste1.42271843
24MP0002822_catalepsy1.32263013
25MP0001485_abnormal_pinna_reflex1.29991748
26MP0002736_abnormal_nociception_after1.28110090
27MP0001486_abnormal_startle_reflex1.25099834
28MP0008877_abnormal_DNA_methylation1.23920396
29MP0000566_synostosis1.23605605
30MP0002653_abnormal_ependyma_morphology1.22219747
31MP0003880_abnormal_central_pattern1.21292129
32MP0002282_abnormal_trachea_morphology1.14631719
33MP0004264_abnormal_extraembryonic_tissu1.13676131
34MP0006292_abnormal_olfactory_placode1.13283623
35MP0003077_abnormal_cell_cycle1.11172845
36MP0009053_abnormal_anal_canal1.11061903
37MP0000534_abnormal_ureter_morphology1.10415783
38MP0001963_abnormal_hearing_physiology1.09547743
39MP0005253_abnormal_eye_physiology1.06693763
40MP0003941_abnormal_skin_development1.02905969
41MP0004957_abnormal_blastocyst_morpholog1.01252268
42MP0000049_abnormal_middle_ear1.00107008
43MP0001765_abnormal_ion_homeostasis0.99915608
44MP0000026_abnormal_inner_ear0.99392520
45MP0002735_abnormal_chemical_nociception0.93609082
46MP0003111_abnormal_nucleus_morphology0.88455295
47MP0002234_abnormal_pharynx_morphology0.84760027
48MP0004782_abnormal_surfactant_physiolog0.81964187
49MP0005167_abnormal_blood-brain_barrier0.81546449
50MP0003119_abnormal_digestive_system0.81085299
51MP0005248_abnormal_Harderian_gland0.80983959
52MP0008789_abnormal_olfactory_epithelium0.80694421
53MP0003693_abnormal_embryo_hatching0.80656554
54MP0005395_other_phenotype0.79412242
55MP0002229_neurodegeneration0.79092522
56MP0005423_abnormal_somatic_nervous0.78387426
57MP0001529_abnormal_vocalization0.77956943
58MP0000470_abnormal_stomach_morphology0.76403672
59MP0009697_abnormal_copulation0.75745044
60MP0005666_abnormal_adipose_tissue0.72171081
61MP0005499_abnormal_olfactory_system0.69490003
62MP0005394_taste/olfaction_phenotype0.69490003
63MP0005551_abnormal_eye_electrophysiolog0.69415002
64MP0001293_anophthalmia0.69138810
65MP0001984_abnormal_olfaction0.67473447
66MP0004742_abnormal_vestibular_system0.66373696
67MP0001346_abnormal_lacrimal_gland0.66266243
68MP0000613_abnormal_salivary_gland0.64800708
69MP0010094_abnormal_chromosome_stability0.64124636
70MP0000955_abnormal_spinal_cord0.62752550
71MP0003937_abnormal_limbs/digits/tail_de0.62567359
72MP0002557_abnormal_social/conspecific_i0.62256213
73MP0004085_abnormal_heartbeat0.59167303
74MP0001501_abnormal_sleep_pattern0.58324444
75MP0002933_joint_inflammation0.57063115
76MP0005391_vision/eye_phenotype0.53895556
77MP0004233_abnormal_muscle_weight0.53587953
78MP0002733_abnormal_thermal_nociception0.53142249
79MP0001286_abnormal_eye_development0.52366121
80MP0003699_abnormal_female_reproductive0.51336062
81MP0001905_abnormal_dopamine_level0.50742779
82MP0003638_abnormal_response/metabolism_0.49365458
83MP0001119_abnormal_female_reproductive0.48375530
84MP0005451_abnormal_body_composition0.48224416
85MP0005332_abnormal_amino_acid0.48177207
86MP0004859_abnormal_synaptic_plasticity0.48153572
87MP0003329_amyloid_beta_deposits0.48081716
88MP0002085_abnormal_embryonic_tissue0.47681526
89MP0008004_abnormal_stomach_pH0.46850676
90MP0001666_abnormal_nutrient_absorption0.46560928
91MP0005636_abnormal_mineral_homeostasis0.45954511
92MP0004133_heterotaxia0.45230411
93MP0008569_lethality_at_weaning0.45191586
94MP0005647_abnormal_sex_gland0.44889683
95MP0003861_abnormal_nervous_system0.44629738
96MP0005595_abnormal_vascular_smooth0.43727583
97MP0003879_abnormal_hair_cell0.43457901
98MP0008775_abnormal_heart_ventricle0.43438829
99MP0009115_abnormal_fat_cell0.42764042
100MP0005275_abnormal_skin_tensile0.41624208

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.77414934
2Absent/shortened dynein arms (HP:0200106)4.91707415
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.91707415
4Infertility (HP:0000789)4.45908269
5Bony spicule pigmentary retinopathy (HP:0007737)4.39791148
6Hyperkalemia (HP:0002153)4.15047545
7Bell-shaped thorax (HP:0001591)4.13347524
8Asymmetric septal hypertrophy (HP:0001670)4.07796377
9Abnormal respiratory motile cilium physiology (HP:0012261)4.04279162
10Chronic hepatic failure (HP:0100626)3.99169478
11Attenuation of retinal blood vessels (HP:0007843)3.96699537
12Abnormal ciliary motility (HP:0012262)3.95212930
13Impulsivity (HP:0100710)3.88868464
14Resting tremor (HP:0002322)3.75580546
15Abnormal respiratory motile cilium morphology (HP:0005938)3.59852688
16Abnormal respiratory epithelium morphology (HP:0012253)3.59852688
17Tubulointerstitial nephritis (HP:0001970)3.51391330
18Hypoplastic ischia (HP:0003175)3.48867496
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45143121
20Aplasia/Hypoplasia of the earlobes (HP:0009906)3.41174215
21Male infertility (HP:0003251)3.20856298
22Esophageal atresia (HP:0002032)3.09491748
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07344892
24Chronic bronchitis (HP:0004469)3.03822044
25Abnormal spermatogenesis (HP:0008669)3.01623537
26Abnormality of the aortic arch (HP:0012303)2.98343437
27Abnormality of the ischium (HP:0003174)2.96695834
28Cone-rod dystrophy (HP:0000548)2.84741697
29Abnormality of macular pigmentation (HP:0008002)2.83107754
30Double outlet right ventricle (HP:0001719)2.72662007
31Congenital malformation of the right heart (HP:0011723)2.72662007
32Abnormal rod and cone electroretinograms (HP:0008323)2.72486146
33Enlarged epiphyses (HP:0010580)2.72025239
34Absent epiphyses (HP:0010577)2.71646881
35Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.71646881
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70114956
37Hypoplasia of the thymus (HP:0000778)2.69848586
38Progressive sensorineural hearing impairment (HP:0000408)2.63584502
39Renal dysplasia (HP:0000110)2.61272696
40Potter facies (HP:0002009)2.59237005
41Facial shape deformation (HP:0011334)2.59237005
42Nasal polyposis (HP:0100582)2.57455063
43Muscle fiber atrophy (HP:0100295)2.53917205
44Postural instability (HP:0002172)2.53749884
45Nephronophthisis (HP:0000090)2.50846038
46Amelogenesis imperfecta (HP:0000705)2.47837798
47Abnormality of the epiphysis of the femoral head (HP:0010574)2.47611565
48Myokymia (HP:0002411)2.41608313
49Azoospermia (HP:0000027)2.40277082
50Absent thumb (HP:0009777)2.37304991
51Rhinitis (HP:0012384)2.32820061
52Supernumerary ribs (HP:0005815)2.32312869
53Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.31904422
54Abnormality of femoral epiphyses (HP:0006499)2.31904422
55Abnormality of the costochondral junction (HP:0000919)2.24427873
56Abnormality of the femoral head (HP:0003368)2.22388271
57Optic nerve hypoplasia (HP:0000609)2.20796788
58Truncal obesity (HP:0001956)2.19639177
59Stage 5 chronic kidney disease (HP:0003774)2.17629909
60Abnormal urine output (HP:0012590)2.17209362
61Epiphyseal dysplasia (HP:0002656)2.16016871
62Abnormality of potassium homeostasis (HP:0011042)2.11063345
63Gastrointestinal atresia (HP:0002589)2.10771760
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10098002
65Progressive cerebellar ataxia (HP:0002073)2.09624811
66Type 2 muscle fiber atrophy (HP:0003554)2.08722935
67Short tibia (HP:0005736)2.08463088
68Cerebellar dysplasia (HP:0007033)2.06974477
69Supernumerary bones of the axial skeleton (HP:0009144)2.06765036
70Abnormality of dental color (HP:0011073)2.06650897
71Flattened epiphyses (HP:0003071)2.06232825
72Anterior segment dysgenesis (HP:0007700)2.06200978
73Abnormality of the renal medulla (HP:0100957)2.03854100
74Mixed hearing impairment (HP:0000410)2.02834296
75Abdominal situs inversus (HP:0003363)2.02482637
76Abnormality of abdominal situs (HP:0011620)2.02482637
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02470783
78Fibular hypoplasia (HP:0003038)2.01658047
79Abnormality of chloride homeostasis (HP:0011422)1.96947439
80Abnormality of the pubic bones (HP:0003172)1.95608785
81Bronchiectasis (HP:0002110)1.95244306
82Stereotypic behavior (HP:0000733)1.93384331
83Retinal dysplasia (HP:0007973)1.92492232
84Occipital encephalocele (HP:0002085)1.92289040
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.91419728
86Abnormality of the nasal mucosa (HP:0000433)1.87661637
87Respiratory distress (HP:0002098)1.84511839
88Abnormality of DNA repair (HP:0003254)1.83317682
89Intellectual disability, moderate (HP:0002342)1.82698977
90Abnormality of renal excretion (HP:0011036)1.82624849
91Vertebral clefting (HP:0008428)1.80961427
92Polyuria (HP:0000103)1.79371169
93Abnormality of the parathyroid morphology (HP:0011766)1.79184512
94Long foot (HP:0001833)1.78687163
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76531568
96Flat capital femoral epiphysis (HP:0003370)1.76486996
97Hyponatremia (HP:0002902)1.75190025
98Type I transferrin isoform profile (HP:0003642)1.75034301
99Osteomalacia (HP:0002749)1.72756956
100Portal hypertension (HP:0001409)1.72506248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.65491979
2TAOK35.18500339
3TESK14.91380547
4DDR23.86645310
5INSRR3.46645310
6BRD42.88549933
7MAP4K22.57471645
8CAMK1G2.46450562
9PLK22.39794990
10ZAK2.36394402
11MST1R2.14424796
12MAP2K22.13966654
13MAPK152.11403063
14STK382.09854902
15PNCK1.95993197
16STK38L1.87690663
17GRK51.82530698
18CDC71.65755645
19CAMK1D1.47320418
20PRKD31.46963550
21GRK61.39829853
22CDK121.37409250
23CDK71.36241812
24WNK11.26575749
25MAPKAPK31.18383113
26DYRK1B1.14058243
27PDK10.98378898
28PDPK10.97459139
29PRKG20.94654541
30WNK40.89265489
31CDK190.88048425
32PIK3CG0.88044023
33PTK2B0.87695600
34SRPK10.83400315
35TIE10.75804535
36RPS6KA10.75446563
37STK160.75444961
38EPHA40.74844796
39RPS6KA40.74705929
40RPS6KA20.71352522
41NEK60.67321973
42IRAK20.66356454
43MAP3K110.64223001
44NEK20.63786599
45OXSR10.63184404
46CAMK10.62980275
47CDK20.62801413
48TYRO30.57777787
49CHEK10.57356005
50EEF2K0.56118933
51BRSK10.55658417
52DYRK30.54776820
53PIM10.54767898
54CDK10.52879213
55PLK10.52875492
56ATR0.52731037
57PRKG10.50988599
58PASK0.49129716
59CHEK20.48381447
60LATS20.47914914
61DYRK20.47282079
62AURKA0.46771408
63MTOR0.45554159
64MAPK10.43825397
65PRKAA20.43722260
66UHMK10.43030798
67TESK20.40928483
68CDK30.40500309
69GSK3B0.40447813
70STK390.40343183
71CDK40.39432115
72MET0.38800597
73FGFR20.37808153
74RPS6KC10.37371006
75RPS6KL10.37371006
76MUSK0.34764817
77BMX0.33259301
78RPS6KA60.33083697
79MAPK140.32845665
80CAMK40.31040280
81FGFR10.29785662
82PRKCG0.27602192
83RIPK10.27593781
84SIK20.27524182
85MAP3K80.26797586
86NUAK10.26553541
87ATM0.26164686
88IKBKB0.26040859
89NME10.25479130
90TNK20.24391407
91ROCK10.23686707
92PRKCZ0.23492426
93AKT30.22448883
94ADRBK20.21791334
95BRSK20.21066197
96CSF1R0.20695554
97MAPK80.19537389
98PRKCB0.19394040
99CHUK0.17877233
100MAP2K10.17576654

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.65301499
2Fatty acid biosynthesis_Homo sapiens_hsa000614.43038153
3Selenocompound metabolism_Homo sapiens_hsa004503.35985814
4Olfactory transduction_Homo sapiens_hsa047403.31003349
5RNA transport_Homo sapiens_hsa030133.03581338
6Taste transduction_Homo sapiens_hsa047422.23952266
7Salivary secretion_Homo sapiens_hsa049702.10599327
8RNA polymerase_Homo sapiens_hsa030201.90664718
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73968194
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.70362037
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53977230
12Butanoate metabolism_Homo sapiens_hsa006501.50091710
13One carbon pool by folate_Homo sapiens_hsa006701.49604631
14mRNA surveillance pathway_Homo sapiens_hsa030151.36341295
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35003198
16Fanconi anemia pathway_Homo sapiens_hsa034601.34470779
17DNA replication_Homo sapiens_hsa030301.33985175
18Arginine biosynthesis_Homo sapiens_hsa002201.33113452
19Pyrimidine metabolism_Homo sapiens_hsa002401.31873314
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30765765
21Inositol phosphate metabolism_Homo sapiens_hsa005621.30131875
22RNA degradation_Homo sapiens_hsa030181.28276230
23Phenylalanine metabolism_Homo sapiens_hsa003601.22547407
24Arginine and proline metabolism_Homo sapiens_hsa003301.20845401
25Biosynthesis of amino acids_Homo sapiens_hsa012301.18027830
26Base excision repair_Homo sapiens_hsa034101.17983754
27Purine metabolism_Homo sapiens_hsa002301.17816963
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16373627
29Retinol metabolism_Homo sapiens_hsa008301.12538054
30Linoleic acid metabolism_Homo sapiens_hsa005911.06221369
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06203267
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01367093
33Spliceosome_Homo sapiens_hsa030401.01000411
34Endocytosis_Homo sapiens_hsa041440.96654051
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95970014
36Cardiac muscle contraction_Homo sapiens_hsa042600.91672408
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90789886
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90228309
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90136722
40Fatty acid degradation_Homo sapiens_hsa000710.88243418
41Autoimmune thyroid disease_Homo sapiens_hsa053200.87861968
42Allograft rejection_Homo sapiens_hsa053300.81933350
43Fat digestion and absorption_Homo sapiens_hsa049750.80893270
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79719183
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77880688
46Oocyte meiosis_Homo sapiens_hsa041140.77498305
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.75934249
48Protein digestion and absorption_Homo sapiens_hsa049740.75606604
49Graft-versus-host disease_Homo sapiens_hsa053320.74587473
50Type I diabetes mellitus_Homo sapiens_hsa049400.74366160
51Hedgehog signaling pathway_Homo sapiens_hsa043400.72371642
52Huntingtons disease_Homo sapiens_hsa050160.70479999
53Viral myocarditis_Homo sapiens_hsa054160.70383195
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70307138
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.69469862
56Morphine addiction_Homo sapiens_hsa050320.68666044
57Antigen processing and presentation_Homo sapiens_hsa046120.68153918
58Lysine degradation_Homo sapiens_hsa003100.65048860
59Tight junction_Homo sapiens_hsa045300.64048146
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63893413
61Acute myeloid leukemia_Homo sapiens_hsa052210.61976411
62Calcium signaling pathway_Homo sapiens_hsa040200.60500119
63Adherens junction_Homo sapiens_hsa045200.59736207
64Nicotine addiction_Homo sapiens_hsa050330.59588711
65Sulfur relay system_Homo sapiens_hsa041220.59266454
66Fatty acid metabolism_Homo sapiens_hsa012120.58297490
67Epstein-Barr virus infection_Homo sapiens_hsa051690.56583016
68Renin secretion_Homo sapiens_hsa049240.56514170
69Metabolic pathways_Homo sapiens_hsa011000.56163212
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55414212
71Tyrosine metabolism_Homo sapiens_hsa003500.52387454
72Viral carcinogenesis_Homo sapiens_hsa052030.52139317
73Mismatch repair_Homo sapiens_hsa034300.50634595
74Pyruvate metabolism_Homo sapiens_hsa006200.48816135
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48716864
76Renin-angiotensin system_Homo sapiens_hsa046140.45432250
77Phototransduction_Homo sapiens_hsa047440.45260752
78cAMP signaling pathway_Homo sapiens_hsa040240.43989804
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43477865
80Arachidonic acid metabolism_Homo sapiens_hsa005900.41910110
81Homologous recombination_Homo sapiens_hsa034400.41561725
82ABC transporters_Homo sapiens_hsa020100.40851194
83Type II diabetes mellitus_Homo sapiens_hsa049300.40579854
84Steroid biosynthesis_Homo sapiens_hsa001000.39941476
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39934952
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38066696
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.37281064
88Cell cycle_Homo sapiens_hsa041100.36946608
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36334350
90Serotonergic synapse_Homo sapiens_hsa047260.36085936
91Herpes simplex infection_Homo sapiens_hsa051680.35946429
92Thyroid hormone synthesis_Homo sapiens_hsa049180.35837917
93Ribosome_Homo sapiens_hsa030100.35471372
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35105923
95Chemical carcinogenesis_Homo sapiens_hsa052040.34097558
96MAPK signaling pathway_Homo sapiens_hsa040100.32766333
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32271829
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31739050
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.30824175
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29405724

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