PRB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Small' allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)8.32281908
2glucocorticoid metabolic process (GO:0008211)7.69194787
3cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.80566990
4establishment of nucleus localization (GO:0040023)6.58163811
5cellular response to gonadotropin stimulus (GO:0071371)6.57091833
6low-density lipoprotein particle clearance (GO:0034383)6.19943926
7amyloid precursor protein catabolic process (GO:0042987)5.95266275
8estrogen biosynthetic process (GO:0006703)5.84132880
9sterol catabolic process (GO:0016127)5.75472035
10cholesterol catabolic process (GO:0006707)5.75472035
11negative regulation of axon extension involved in axon guidance (GO:0048843)5.38551977
12hemoglobin metabolic process (GO:0020027)5.37002189
13regulation of transforming growth factor beta2 production (GO:0032909)5.30229394
14response to follicle-stimulating hormone (GO:0032354)5.23432799
15adhesion of symbiont to host (GO:0044406)5.13149508
16regulation of gonadotropin secretion (GO:0032276)5.11068435
17positive regulation of male gonad development (GO:2000020)5.06150204
18axon extension involved in axon guidance (GO:0048846)4.99797458
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.99797458
20negative regulation of macrophage differentiation (GO:0045650)4.89932601
21response to gonadotropin (GO:0034698)4.61607838
22endothelial cell chemotaxis (GO:0035767)4.58968455
23positive regulation of triglyceride biosynthetic process (GO:0010867)4.48769051
24DNA strand renaturation (GO:0000733)4.36332929
25fibroblast migration (GO:0010761)4.28919132
26negative regulation of axon guidance (GO:1902668)4.25810316
27phagocytosis, recognition (GO:0006910)4.24796935
28growth hormone secretion (GO:0030252)4.24460549
29regulation of cholesterol storage (GO:0010885)4.16004692
30cellular response to epinephrine stimulus (GO:0071872)4.13178327
31vitamin A metabolic process (GO:0006776)4.07285863
32histone H3-K4 trimethylation (GO:0080182)4.05673938
33negative regulation of JUN kinase activity (GO:0043508)3.91966484
34nucleus localization (GO:0051647)3.91285021
35detection of molecule of bacterial origin (GO:0032490)3.90550971
36regulation of axon extension involved in axon guidance (GO:0048841)3.83527541
37regulation of male gonad development (GO:2000018)3.79511103
38androgen metabolic process (GO:0008209)3.78623482
39positive regulation of nitric-oxide synthase activity (GO:0051000)3.73144474
40C21-steroid hormone biosynthetic process (GO:0006700)3.72819661
41regulation of triglyceride biosynthetic process (GO:0010866)3.70487851
42positive regulation by host of viral transcription (GO:0043923)3.66837810
43hormone biosynthetic process (GO:0042446)3.65477515
44endothelial cell proliferation (GO:0001935)3.58013876
45positive regulation of triglyceride metabolic process (GO:0090208)3.55526631
46positive regulation of astrocyte differentiation (GO:0048711)3.51924729
47amyloid precursor protein metabolic process (GO:0042982)3.50810982
48male genitalia development (GO:0030539)3.49123325
49toxin metabolic process (GO:0009404)3.44001582
50negative chemotaxis (GO:0050919)3.39978969
51glucocorticoid receptor signaling pathway (GO:0042921)3.39899159
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39352387
53ganglion development (GO:0061548)3.38064864
54high-density lipoprotein particle remodeling (GO:0034375)3.36342506
55sulfate transmembrane transport (GO:1902358)3.36269444
56regulation of transforming growth factor beta1 production (GO:0032908)3.29808451
57response to epinephrine (GO:0071871)3.29121895
58regulation of axon guidance (GO:1902667)3.28815224
59regulation of translation, ncRNA-mediated (GO:0045974)3.24600490
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24600490
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.24600490
62negative regulation of catenin import into nucleus (GO:0035414)3.22712352
63regulation of interferon-gamma biosynthetic process (GO:0045072)3.15590264
64reverse cholesterol transport (GO:0043691)3.08639251
65neuronal stem cell maintenance (GO:0097150)3.06333876
66cellular response to cadmium ion (GO:0071276)3.03956307
67regulation of female gonad development (GO:2000194)3.03783900
68cellular response to antibiotic (GO:0071236)3.02035443
69pattern specification involved in kidney development (GO:0061004)2.97925515
70blood vessel endothelial cell migration (GO:0043534)2.88277332
71myelin assembly (GO:0032288)2.86700140
72negative regulation of axon extension (GO:0030517)2.84205135
73histone H3-K4 methylation (GO:0051568)2.83815031
74regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.83256672
75regulation of fever generation (GO:0031620)2.78814487
76negative regulation of hormone biosynthetic process (GO:0032353)2.75947311
77positive regulation of lipid storage (GO:0010884)2.75296707
78chondrocyte development (GO:0002063)2.73996443
79regulation of triglyceride metabolic process (GO:0090207)2.72904130
80regulation of sarcomere organization (GO:0060297)2.71921665
81chondroitin sulfate biosynthetic process (GO:0030206)2.70834815
82facial nerve structural organization (GO:0021612)2.69937087
83reproductive system development (GO:0061458)2.69070095
84sulfate transport (GO:0008272)2.68726553
85cellular response to growth hormone stimulus (GO:0071378)2.66838471
86kidney morphogenesis (GO:0060993)2.62871210
87limb development (GO:0060173)2.62823004
88appendage development (GO:0048736)2.62823004
89response to misfolded protein (GO:0051788)2.62528514
90progesterone metabolic process (GO:0042448)2.61600963
91corticosteroid receptor signaling pathway (GO:0031958)2.59215292
92cellular response to toxic substance (GO:0097237)2.56042755
93protein retention in ER lumen (GO:0006621)2.54087219
94cellular response to interferon-alpha (GO:0035457)2.53489901
95steroid catabolic process (GO:0006706)2.53300153
96positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52605688
97steroid biosynthetic process (GO:0006694)2.52062101
98response to lipoprotein particle (GO:0055094)2.51591757
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49766574
100glucocorticoid biosynthetic process (GO:0006704)10.3337278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.32906944
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse5.22284397
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.84901915
4DROSHA_22980978_ChIP-Seq_HELA_Human3.24368597
5AR_21572438_ChIP-Seq_LNCaP_Human2.60705116
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35668186
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31843688
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30050110
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.07941959
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95943748
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95590562
12ESR1_20079471_ChIP-ChIP_T-47D_Human1.94012160
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91069940
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90158736
15CDX2_20551321_ChIP-Seq_CACO-2_Human1.85296359
16NFIB_24661679_ChIP-Seq_LUNG_Mouse1.84358548
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83095325
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83066960
19TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82683014
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74480820
21TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.70561717
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.68671840
23GBX2_23144817_ChIP-Seq_PC3_Human1.67307484
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64034530
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61397937
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61112284
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.58292997
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.56980532
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54561076
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.51751624
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50647009
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.47193164
33YAP1_20516196_ChIP-Seq_MESCs_Mouse1.46541972
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.46343257
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.36928435
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.36544855
37WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36067510
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35294138
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34888551
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31877904
41* RUNX1_27514584_Chip-Seq_MCF-7_Human1.31696922
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30296684
43LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29455699
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29200417
45CLOCK_20551151_ChIP-Seq_293T_Human1.28753856
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27202383
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26947639
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25974142
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24656566
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24656566
51AHR_22903824_ChIP-Seq_MCF-7_Human1.20778325
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.20695253
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20617585
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20363304
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20057482
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18941680
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16834538
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16728477
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16706774
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16089757
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15932232
62PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13958346
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13740248
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11467779
65AR_19668381_ChIP-Seq_PC3_Human1.11268436
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08939930
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.08124600
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07500186
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07316325
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06295166
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05836994
72SMAD4_21741376_ChIP-Seq_HESCs_Human1.05833074
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.05817012
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05550361
75STAT3_23295773_ChIP-Seq_U87_Human1.04618570
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03843616
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03674596
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.03207088
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02528386
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01309056
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00305249
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00226636
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00208491
84GF1_26923725_Chip-Seq_HPCs_Mouse1.00185746
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99789757
86SOX2_21211035_ChIP-Seq_LN229_Gbm0.99534106
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.99258583
88LXR_22158963_ChIP-Seq_LIVER_Mouse0.98154816
89SMAD4_21799915_ChIP-Seq_A2780_Human0.97662395
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97158883
91POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96472087
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95876000
93KDM2B_26808549_Chip-Seq_K562_Human0.95523354
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95044992
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.94781597
96ERG_21242973_ChIP-ChIP_JURKAT_Human0.94552095
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93680065
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92014047
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.91784155
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90545427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.42319780
2MP0003011_delayed_dark_adaptation3.12228105
3MP0005670_abnormal_white_adipose2.59640873
4MP0004145_abnormal_muscle_electrophysio2.35504609
5MP0002909_abnormal_adrenal_gland2.35019365
6MP0001661_extended_life_span2.13836272
7MP0000639_abnormal_adrenal_gland2.06672768
8MP0004858_abnormal_nervous_system2.03573975
9MP0008004_abnormal_stomach_pH13.2409210
10MP0005076_abnormal_cell_differentiation1.85844389
11MP0002249_abnormal_larynx_morphology1.68186147
12MP0003136_yellow_coat_color1.66857673
13MP0002653_abnormal_ependyma_morphology1.61813489
14MP0005423_abnormal_somatic_nervous1.60457979
15MP0003828_pulmonary_edema1.58500647
16MP0001502_abnormal_circadian_rhythm1.56790899
17MP0000470_abnormal_stomach_morphology1.54463687
18MP0010329_abnormal_lipoprotein_level1.49317414
19MP0005409_darkened_coat_color1.44995781
20MP0003943_abnormal_hepatobiliary_system1.42950525
21MP0002638_abnormal_pupillary_reflex1.42149802
22MP0001851_eye_inflammation1.38090390
23MP0010368_abnormal_lymphatic_system1.33908761
24MP0005334_abnormal_fat_pad1.28219117
25MP0009250_abnormal_appendicular_skeleto1.28110752
26MP0003300_gastrointestinal_ulcer1.20158638
27MP0005499_abnormal_olfactory_system1.19469427
28MP0005394_taste/olfaction_phenotype1.19469427
29MP0002876_abnormal_thyroid_physiology1.18384231
30MP0005508_abnormal_skeleton_morphology1.17747304
31MP0002332_abnormal_exercise_endurance1.17172458
32MP0004859_abnormal_synaptic_plasticity1.17113246
33MP0004233_abnormal_muscle_weight1.16489938
34MP0008875_abnormal_xenobiotic_pharmacok1.16217001
35MP0008789_abnormal_olfactory_epithelium1.15889846
36MP0002928_abnormal_bile_duct1.15164593
37MP0000013_abnormal_adipose_tissue1.09787946
38MP0000631_abnormal_neuroendocrine_gland1.09366612
39MP0000678_abnormal_parathyroid_gland1.08313888
40MP0001873_stomach_inflammation1.04345288
41MP0008872_abnormal_physiological_respon1.01190984
42MP0002896_abnormal_bone_mineralization0.97762706
43MP0003953_abnormal_hormone_level0.97544689
44MP0010386_abnormal_urinary_bladder0.95018512
45MP0003183_abnormal_peptide_metabolism0.89200028
46MP0002090_abnormal_vision0.88257987
47MP0002697_abnormal_eye_size0.86621562
48MP0009745_abnormal_behavioral_response0.85360883
49MP0001501_abnormal_sleep_pattern0.78818871
50MP0001970_abnormal_pain_threshold0.76973008
51MP0005448_abnormal_energy_balance0.74940420
52MP0005503_abnormal_tendon_morphology0.74895914
53MP0002736_abnormal_nociception_after0.73576791
54MP0004883_abnormal_blood_vessel0.73399833
55MP0008569_lethality_at_weaning0.73123065
56MP0001270_distended_abdomen0.73088158
57MP0003699_abnormal_female_reproductive0.72990143
58MP0000627_abnormal_mammary_gland0.72583541
59MP0000538_abnormal_urinary_bladder0.71830151
60MP0003936_abnormal_reproductive_system0.70804995
61MP0002734_abnormal_mechanical_nocicepti0.69764152
62MP0008007_abnormal_cellular_replicative0.69043564
63MP0002735_abnormal_chemical_nociception0.68537049
64MP0000778_abnormal_nervous_system0.68390337
65MP0005646_abnormal_pituitary_gland0.68285016
66MP0002277_abnormal_respiratory_mucosa0.67763512
67MP0002184_abnormal_innervation0.65789222
68MP0004272_abnormal_basement_membrane0.65783452
69MP0003091_abnormal_cell_migration0.65081029
70MP0001881_abnormal_mammary_gland0.64665886
71MP0006276_abnormal_autonomic_nervous0.63285056
72MP0005174_abnormal_tail_pigmentation0.63251471
73MP0003635_abnormal_synaptic_transmissio0.61829812
74MP0002108_abnormal_muscle_morphology0.61762638
75MP0002877_abnormal_melanocyte_morpholog0.61761740
76MP0005023_abnormal_wound_healing0.61032375
77MP0002063_abnormal_learning/memory/cond0.60360487
78MP0001664_abnormal_digestion0.59162295
79MP0010030_abnormal_orbit_morphology0.58342448
80MP0002932_abnormal_joint_morphology0.57997244
81MP0002089_abnormal_postnatal_growth/wei0.57576896
82MP0005085_abnormal_gallbladder_physiolo0.56299950
83MP0002572_abnormal_emotion/affect_behav0.55291209
84MP0004808_abnormal_hematopoietic_stem0.54497545
85MP0003868_abnormal_feces_composition0.54416561
86MP0000747_muscle_weakness0.54382135
87MP0001324_abnormal_eye_pigmentation0.54286644
88MP0002970_abnormal_white_adipose0.53920274
89MP0004215_abnormal_myocardial_fiber0.53874759
90MP0001299_abnormal_eye_distance/0.53730212
91MP0005187_abnormal_penis_morphology0.52688304
92MP0004134_abnormal_chest_morphology0.51804918
93MP0001963_abnormal_hearing_physiology0.51658327
94MP0008775_abnormal_heart_ventricle0.51617161
95MP0003890_abnormal_embryonic-extraembry0.51583599
96MP0002998_abnormal_bone_remodeling0.51554615
97MP0003948_abnormal_gas_homeostasis0.50890067
98MP0003279_aneurysm0.50757169
99MP0009115_abnormal_fat_cell0.47764977
100MP0002733_abnormal_thermal_nociception0.47017971

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)7.91268327
2Oligodactyly (HP:0012165)5.95095518
3Genetic anticipation (HP:0003743)5.31641835
4Diastasis recti (HP:0001540)5.24176096
5Large earlobe (HP:0009748)4.69586444
6Split foot (HP:0001839)4.56209827
7Anomalous pulmonary venous return (HP:0010772)4.51374483
8Relative macrocephaly (HP:0004482)4.49136775
9Stenosis of the external auditory canal (HP:0000402)4.08827120
10Abnormality of the pulmonary veins (HP:0011718)3.88361396
11Ureteral duplication (HP:0000073)3.85093068
12Hypoplastic nipples (HP:0002557)3.73464595
13Partial agenesis of the corpus callosum (HP:0001338)3.71054395
14Mixed hearing impairment (HP:0000410)3.44094847
15Abnormality of the aortic arch (HP:0012303)3.41426518
16Vertebral arch anomaly (HP:0008438)3.31521084
17Cupped ear (HP:0000378)3.20260068
18Rhizomelia (HP:0008905)3.14131757
19Oligodontia (HP:0000677)3.11862651
20Choroideremia (HP:0001139)3.08212274
21Limited elbow extension (HP:0001377)2.97474188
22Progressive cerebellar ataxia (HP:0002073)2.95570454
23Renal salt wasting (HP:0000127)2.94395730
24Anteriorly placed anus (HP:0001545)2.91406582
25Anophthalmia (HP:0000528)2.86055048
26Supernumerary ribs (HP:0005815)2.83271175
27Double outlet right ventricle (HP:0001719)2.76666566
28Congenital malformation of the right heart (HP:0011723)2.76666566
29Narrow nasal bridge (HP:0000446)2.74580359
30Labial hypoplasia (HP:0000066)2.71729779
31Severe visual impairment (HP:0001141)2.66982844
32Tibial bowing (HP:0002982)2.65280767
33Urethral obstruction (HP:0000796)2.64996629
34Supernumerary bones of the axial skeleton (HP:0009144)2.62110501
35Fibular hypoplasia (HP:0003038)2.60657228
36Long eyelashes (HP:0000527)2.57481431
37Abnormality of the columella (HP:0009929)2.51776146
38Abnormality of the fingertips (HP:0001211)2.50987964
39Hypoplastic iliac wings (HP:0002866)2.50503675
40Hypoplastic female external genitalia (HP:0012815)2.46093245
41Vertebral clefting (HP:0008428)2.44126989
42Diplopia (HP:0000651)2.40144735
43Abnormality of binocular vision (HP:0011514)2.40144735
44Precocious puberty (HP:0000826)2.37874081
45Ulnar bowing (HP:0003031)2.36136545
46Increased density of long bones (HP:0006392)2.30425408
47Abnormality of the nasal septum (HP:0000419)2.30245637
48Broad face (HP:0000283)2.29505624
49Accelerated skeletal maturation (HP:0005616)2.29490416
50Hyperaldosteronism (HP:0000859)2.27407987
51Acanthosis nigricans (HP:0000956)2.25528256
52Hypoplasia of dental enamel (HP:0006297)2.22044347
53Aplasia/Hypoplasia of the fibula (HP:0006492)2.18825302
54Neoplasm of the heart (HP:0100544)2.17373266
55Abnormality of the parietal bone (HP:0002696)2.17238717
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16295222
57Periauricular skin pits (HP:0100277)2.14581820
58Preauricular pit (HP:0004467)2.14581820
59Gaze-evoked nystagmus (HP:0000640)2.13646680
60Abnormality of the alveolar ridges (HP:0006477)2.11161411
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06650595
62Ectopic kidney (HP:0000086)2.05455299
63Small epiphyses (HP:0010585)2.05281944
64Abnormal sex determination (HP:0012244)2.05134152
65Sex reversal (HP:0012245)2.05134152
66Short clavicles (HP:0000894)2.04323601
67Chronic hepatic failure (HP:0100626)2.01051200
68Abnormality of the distal phalanx of the thumb (HP:0009617)2.00511815
69Macroorchidism (HP:0000053)1.99120587
70Intestinal malrotation (HP:0002566)1.99058286
71Myelomeningocele (HP:0002475)1.97757079
72Aplasia/Hypoplasia of the clavicles (HP:0006710)1.97437950
73Tubular atrophy (HP:0000092)1.93593371
74Anal stenosis (HP:0002025)1.92201504
75Dysmetric saccades (HP:0000641)1.91214802
76Truncal obesity (HP:0001956)1.88719692
77Hyperactive renin-angiotensin system (HP:0000841)1.88482319
78Intestinal atresia (HP:0011100)1.87809094
79Cerebral palsy (HP:0100021)1.87605281
80Flattened epiphyses (HP:0003071)1.87257247
81Abnormal drinking behavior (HP:0030082)1.86776959
82Polydipsia (HP:0001959)1.86776959
83Popliteal pterygium (HP:0009756)1.86023681
84Aortic regurgitation (HP:0001659)1.82961715
85Persistence of primary teeth (HP:0006335)1.82914553
86Abnormal ossification of hand bones (HP:0005921)1.81214816
87Optic nerve coloboma (HP:0000588)1.81153382
88Abnormality of the intervertebral disk (HP:0005108)1.80200614
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.79415597
90Abnormality of the diencephalon (HP:0010662)1.79237680
91Increased nuchal translucency (HP:0010880)1.79075439
92Bowed forearm bones (HP:0003956)1.78332818
93Bowing of the arm (HP:0006488)1.78332818
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78088052
95Absent epiphyses (HP:0010577)1.78088052
96Abnormality of the pubic bones (HP:0003172)1.77401681
97Esophageal atresia (HP:0002032)1.77315371
98Abnormality of the labia (HP:0000058)1.75270520
99Supernumerary nipples (HP:0002558)1.74899967
100Hypoplastic ilia (HP:0000946)1.73140937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.30865809
2PRPF4B6.64077703
3PNCK5.32121644
4TAOK23.64370550
5SIK23.44840258
6NEK22.82334400
7CAMK1G2.47816400
8FRK2.45159545
9CAMK1D1.98310477
10NTRK21.97310216
11CASK1.59506360
12ICK1.56780743
13CDK121.49674219
14CDC42BPA1.42762220
15ACVR1B1.41698875
16CDK31.39936731
17MTOR1.38879308
18VRK11.25395240
19MAP3K71.24899380
20CAMK41.22316729
21PTK21.22064999
22MELK1.16885028
23TSSK61.09583255
24DMPK1.03268433
25NEK91.02744304
26TAOK31.02299740
27WEE10.91791094
28BCR0.89346107
29PAK20.88621814
30DDR20.83548582
31PDGFRB0.81022806
32ROCK10.79429476
33CDK80.73021426
34SGK20.72474060
35MAP2K20.71871834
36STK100.70442527
37WNK10.70115724
38BCKDK0.67950719
39STK110.66448993
40ERBB20.65099323
41EPHA30.65077164
42NTRK30.62074265
43SGK30.62035936
44STK380.61301754
45MAPK10.59534327
46JAK10.59250817
47MAPKAPK30.58359045
48NLK0.57367265
49CHUK0.54877512
50SGK2230.52776369
51SGK4940.52776369
52TTN0.52369425
53GSK3A0.51040518
54LATS10.50690866
55RPS6KA60.50070304
56PTK2B0.49926971
57RPS6KC10.49859138
58RPS6KL10.49859138
59MAPK100.49744289
60SIK30.49743745
61PRKD20.49656070
62AKT30.48240940
63MAPK30.47901230
64TRIB30.47895628
65PRKAA10.47743002
66MAPK70.44472685
67MST40.42993076
68ADRBK10.41524695
69ROCK20.40577175
70PRKCH0.40438382
71SGK10.38965680
72MAP3K50.38654683
73AKT10.37485620
74RPS6KA50.37121080
75PRKD10.36857320
76SIK10.35382691
77STK38L0.35297375
78TNIK0.35231451
79GSK3B0.35220835
80PRKD30.33922678
81ERN10.32765667
82PRKAA20.31397702
83RPS6KA30.30184410
84YES10.29211305
85TYRO30.29010496
86RPS6KA10.28648525
87CDK50.27258557
88RET0.26380357
89PRKCZ0.26305627
90MAPK140.26155785
91MAPK90.26059175
92CAMK10.25955520
93INSRR0.25214719
94RPS6KA20.23819389
95CDK20.22617339
96PLK20.22491279
97EPHB20.21542202
98MAPK80.21396177
99PDGFRA0.21070371
100MAP3K30.21046723

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.77345593
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.70533230
3Steroid biosynthesis_Homo sapiens_hsa001004.35370893
4Aldosterone synthesis and secretion_Homo sapiens_hsa049253.05954524
5Lysine degradation_Homo sapiens_hsa003102.79987842
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.74337601
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.24483693
8Notch signaling pathway_Homo sapiens_hsa043302.02144995
9Vitamin digestion and absorption_Homo sapiens_hsa049772.01099636
10Glutamatergic synapse_Homo sapiens_hsa047241.74049633
11Estrogen signaling pathway_Homo sapiens_hsa049151.52371816
12Nicotine addiction_Homo sapiens_hsa050331.42309263
13Cocaine addiction_Homo sapiens_hsa050301.41921047
14Cholinergic synapse_Homo sapiens_hsa047251.40162734
15Focal adhesion_Homo sapiens_hsa045101.35658923
16Fat digestion and absorption_Homo sapiens_hsa049751.34539153
17Bile secretion_Homo sapiens_hsa049761.30625236
18Gastric acid secretion_Homo sapiens_hsa049711.25970140
19Type II diabetes mellitus_Homo sapiens_hsa049301.25019879
20ErbB signaling pathway_Homo sapiens_hsa040121.22537274
21Taste transduction_Homo sapiens_hsa047421.20522244
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20468047
23Choline metabolism in cancer_Homo sapiens_hsa052311.17745180
24Circadian entrainment_Homo sapiens_hsa047131.17399171
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17063584
26ECM-receptor interaction_Homo sapiens_hsa045121.10484988
27GABAergic synapse_Homo sapiens_hsa047271.08677333
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08407445
29Mineral absorption_Homo sapiens_hsa049781.08394868
30Wnt signaling pathway_Homo sapiens_hsa043101.06978577
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.04962998
32Adherens junction_Homo sapiens_hsa045201.03259210
33Serotonergic synapse_Homo sapiens_hsa047261.02781982
34Axon guidance_Homo sapiens_hsa043601.01951805
35Proteoglycans in cancer_Homo sapiens_hsa052051.00133767
36GnRH signaling pathway_Homo sapiens_hsa049120.99940618
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.99636138
38Insulin secretion_Homo sapiens_hsa049110.99325924
39Morphine addiction_Homo sapiens_hsa050320.98276809
40Circadian rhythm_Homo sapiens_hsa047100.94427888
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93522107
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92417175
43Dilated cardiomyopathy_Homo sapiens_hsa054140.89872629
44Chemical carcinogenesis_Homo sapiens_hsa052040.89518621
45cAMP signaling pathway_Homo sapiens_hsa040240.88909868
46Renal cell carcinoma_Homo sapiens_hsa052110.88002940
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84471579
48MAPK signaling pathway_Homo sapiens_hsa040100.83240309
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.82410132
50Salivary secretion_Homo sapiens_hsa049700.82186534
51TGF-beta signaling pathway_Homo sapiens_hsa043500.81607769
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81085919
53Tight junction_Homo sapiens_hsa045300.80585234
54Hedgehog signaling pathway_Homo sapiens_hsa043400.78540019
55Oxytocin signaling pathway_Homo sapiens_hsa049210.76660376
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76501290
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75876408
58Dopaminergic synapse_Homo sapiens_hsa047280.72971640
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72821343
60Thyroid hormone synthesis_Homo sapiens_hsa049180.68717315
61Prion diseases_Homo sapiens_hsa050200.67746901
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66245047
63mTOR signaling pathway_Homo sapiens_hsa041500.62503816
64FoxO signaling pathway_Homo sapiens_hsa040680.59442357
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58040212
66Long-term depression_Homo sapiens_hsa047300.55993721
67TNF signaling pathway_Homo sapiens_hsa046680.55451514
68Calcium signaling pathway_Homo sapiens_hsa040200.54647050
69Hippo signaling pathway_Homo sapiens_hsa043900.53703415
70Pancreatic secretion_Homo sapiens_hsa049720.52433225
71Tryptophan metabolism_Homo sapiens_hsa003800.52373159
72Colorectal cancer_Homo sapiens_hsa052100.52130813
73Insulin signaling pathway_Homo sapiens_hsa049100.51286348
74Amphetamine addiction_Homo sapiens_hsa050310.50425800
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.49258116
76Prolactin signaling pathway_Homo sapiens_hsa049170.48840109
77ABC transporters_Homo sapiens_hsa020100.47847656
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47140882
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47039999
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46902631
81MicroRNAs in cancer_Homo sapiens_hsa052060.46534006
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46302769
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46041987
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45726695
85Long-term potentiation_Homo sapiens_hsa047200.45685914
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44893241
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43162979
88Hepatitis B_Homo sapiens_hsa051610.41262870
89Melanogenesis_Homo sapiens_hsa049160.40805187
90Amoebiasis_Homo sapiens_hsa051460.39281535
91Alcoholism_Homo sapiens_hsa050340.38478452
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.38183311
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.37104279
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.36128020
95Pathways in cancer_Homo sapiens_hsa052000.35993726
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.35423486
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35184195
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33209164
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32512700
100Renin secretion_Homo sapiens_hsa049240.32228640

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