PRDM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)7.26274765
2regulation of meiosis I (GO:0060631)7.01042803
3regulation of histone H3-K9 methylation (GO:0051570)6.13282294
4negative regulation of histone methylation (GO:0031061)5.92518532
5regulation of female gonad development (GO:2000194)5.56860686
6nuclear pore complex assembly (GO:0051292)5.30341757
7oocyte development (GO:0048599)5.02068783
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.87371265
9nuclear pore organization (GO:0006999)4.86218399
10regulation of acrosome reaction (GO:0060046)4.82985969
11positive regulation of histone H3-K4 methylation (GO:0051571)4.80751081
12multicellular organism reproduction (GO:0032504)4.68536731
13meiotic cell cycle (GO:0051321)4.55893737
14piRNA metabolic process (GO:0034587)4.50785658
15mitotic sister chromatid cohesion (GO:0007064)4.45156230
16histone H3-K9 demethylation (GO:0033169)4.39564600
17mitotic chromosome condensation (GO:0007076)4.35291626
18DNA methylation involved in gamete generation (GO:0043046)4.31036841
19protein localization to kinetochore (GO:0034501)4.27533595
20chromosome condensation (GO:0030261)4.25711042
21protein localization to chromosome, centromeric region (GO:0071459)4.07865370
22DNA packaging (GO:0006323)4.03046751
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.00992928
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.00992928
25positive regulation of mitotic sister chromatid separation (GO:1901970)4.00992928
26microtubule severing (GO:0051013)4.00707635
27histone lysine demethylation (GO:0070076)3.96861629
28positive regulation of histone methylation (GO:0031062)3.91797184
29regulation of histone methylation (GO:0031060)3.86516738
30pore complex assembly (GO:0046931)3.85329464
31mitotic metaphase plate congression (GO:0007080)3.82477903
32retinal cone cell development (GO:0046549)3.72670856
33histone demethylation (GO:0016577)3.71553826
34regulation of centriole replication (GO:0046599)3.71215833
35termination of RNA polymerase III transcription (GO:0006386)3.69508781
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.69508781
37negative regulation of histone modification (GO:0031057)3.68973707
38regulation of histone H3-K4 methylation (GO:0051569)3.68439998
39gene silencing by RNA (GO:0031047)3.67029702
40binding of sperm to zona pellucida (GO:0007339)3.66979537
41pre-miRNA processing (GO:0031054)3.65554090
42single strand break repair (GO:0000012)3.64495336
43DNA double-strand break processing (GO:0000729)3.63089010
44spermatid nucleus differentiation (GO:0007289)3.58960314
45positive regulation of chromosome segregation (GO:0051984)3.55652290
46regulation of chromatin silencing (GO:0031935)3.53363213
47establishment of chromosome localization (GO:0051303)3.53329473
48nucleus organization (GO:0006997)3.48533625
49female gamete generation (GO:0007292)3.47168496
50DNA alkylation (GO:0006305)3.43516093
51DNA methylation (GO:0006306)3.43516093
52DNA replication checkpoint (GO:0000076)3.43504622
53reproduction (GO:0000003)3.41497635
54negative regulation of chromatin modification (GO:1903309)3.40693125
55tRNA methylation (GO:0030488)3.37032703
56negative regulation of DNA-dependent DNA replication (GO:2000104)3.36060383
57microtubule polymerization or depolymerization (GO:0031109)3.36015999
58sister chromatid cohesion (GO:0007062)3.35259463
59N-terminal protein amino acid acetylation (GO:0006474)3.34930963
60positive regulation of gene expression, epigenetic (GO:0045815)3.34592331
61glycine transport (GO:0015816)3.34415406
62telomere maintenance via semi-conservative replication (GO:0032201)3.31134106
63gene silencing (GO:0016458)3.30747895
64metaphase plate congression (GO:0051310)3.30186609
65protein dealkylation (GO:0008214)3.30117060
66protein demethylation (GO:0006482)3.30117060
67replication fork processing (GO:0031297)3.27949073
68histone H3-K36 demethylation (GO:0070544)3.23565402
69regulation of mitotic spindle checkpoint (GO:1903504)3.17763138
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17763138
71telomere maintenance via recombination (GO:0000722)3.16094604
72protein K6-linked ubiquitination (GO:0085020)3.15411640
73stress granule assembly (GO:0034063)3.14626676
74interkinetic nuclear migration (GO:0022027)3.14027869
757-methylguanosine mRNA capping (GO:0006370)3.12466501
76cytoplasmic mRNA processing body assembly (GO:0033962)3.11141704
77somite rostral/caudal axis specification (GO:0032525)3.10231797
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09615199
79regulation of helicase activity (GO:0051095)3.09091229
80sperm-egg recognition (GO:0035036)3.09047030
81RNA capping (GO:0036260)3.08467534
827-methylguanosine RNA capping (GO:0009452)3.08467534
83protein localization to chromosome (GO:0034502)3.05787377
84DNA synthesis involved in DNA repair (GO:0000731)3.05619186
85histone exchange (GO:0043486)3.03834245
86maturation of 5.8S rRNA (GO:0000460)3.03576497
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03397897
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.02253399
89negative regulation of translation, ncRNA-mediated (GO:0040033)3.02253399
90regulation of translation, ncRNA-mediated (GO:0045974)3.02253399
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01579387
92protein kinase C signaling (GO:0070528)3.00551785
93histone H3-K4 trimethylation (GO:0080182)3.00180697
94negative regulation of cAMP-mediated signaling (GO:0043951)2.99951535
95nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.98600334
96positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98360209
97histone H3-K9 methylation (GO:0051567)2.97707178
98natural killer cell activation involved in immune response (GO:0002323)2.97624358
99DNA deamination (GO:0045006)2.97496317
100synapsis (GO:0007129)2.96091571
101DNA replication-dependent nucleosome assembly (GO:0006335)2.95729006
102DNA replication-dependent nucleosome organization (GO:0034723)2.95729006
103negative regulation of mast cell activation (GO:0033004)2.93626923
104centriole assembly (GO:0098534)2.91067793
105regulation of centrosome cycle (GO:0046605)2.90750430
106regulation of RNA export from nucleus (GO:0046831)2.86815926
107startle response (GO:0001964)2.86343887
108replicative senescence (GO:0090399)2.86316958
109DNA strand elongation (GO:0022616)2.86017728
110DNA replication initiation (GO:0006270)2.84325831
111histone H2A acetylation (GO:0043968)2.81046562
112kinetochore assembly (GO:0051382)2.80921999
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.79159095
114microtubule depolymerization (GO:0007019)2.78568752
115acrosome assembly (GO:0001675)2.78024978
116transcription from RNA polymerase I promoter (GO:0006360)2.76723852
117membrane disassembly (GO:0030397)2.75912180
118nuclear envelope disassembly (GO:0051081)2.75912180
119DNA catabolic process, exonucleolytic (GO:0000738)2.74438873
120protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.73737156
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73661665
122histone H3-K4 methylation (GO:0051568)2.73100389
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.72752825
124mitotic recombination (GO:0006312)2.72270286
125negative regulation of gene silencing (GO:0060969)2.71619514
126mitotic nuclear envelope disassembly (GO:0007077)2.70033270
127polyketide metabolic process (GO:0030638)2.69414226
128doxorubicin metabolic process (GO:0044598)2.69414226
129daunorubicin metabolic process (GO:0044597)2.69414226
130termination of RNA polymerase I transcription (GO:0006363)2.69378060
131DNA strand elongation involved in DNA replication (GO:0006271)2.67811874
132intraciliary transport (GO:0042073)2.67510789
133positive regulation of humoral immune response (GO:0002922)2.66579383
134transcription-coupled nucleotide-excision repair (GO:0006283)2.66293132
135DNA strand renaturation (GO:0000733)2.65970278
136interferon-gamma production (GO:0032609)2.65798899
137telomere maintenance via telomere lengthening (GO:0010833)2.65654328
138regulation of gene expression by genetic imprinting (GO:0006349)2.64220452
139vesicle transport along microtubule (GO:0047496)2.63773730
140DNA replication-independent nucleosome assembly (GO:0006336)2.63190457
141DNA replication-independent nucleosome organization (GO:0034724)2.63190457
142rRNA modification (GO:0000154)2.63157777
143preassembly of GPI anchor in ER membrane (GO:0016254)2.62234890
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61584112
145cellular response to gamma radiation (GO:0071480)2.60820910
146positive regulation of protein homodimerization activity (GO:0090073)2.59425737
147tRNA modification (GO:0006400)2.59417997
148viral mRNA export from host cell nucleus (GO:0046784)2.58036790
149response to pheromone (GO:0019236)2.55938584
150RNA methylation (GO:0001510)2.53592553
151mismatch repair (GO:0006298)2.52760403
152DNA-dependent DNA replication (GO:0006261)2.52326223
153kinetochore organization (GO:0051383)2.52092487
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46658387
155transcription initiation from RNA polymerase I promoter (GO:0006361)2.46027397
156telomere organization (GO:0032200)2.45908583
157purine nucleobase biosynthetic process (GO:0009113)2.45843959
158somatic hypermutation of immunoglobulin genes (GO:0016446)2.45537883
159somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45537883
160telomere maintenance (GO:0000723)2.45240065
161DNA-templated transcription, elongation (GO:0006354)2.44882164
162CENP-A containing nucleosome assembly (GO:0034080)2.43873173
163snRNA processing (GO:0016180)2.43799210
164GPI anchor biosynthetic process (GO:0006506)2.43545660
165transcription elongation from RNA polymerase II promoter (GO:0006368)2.43443757
166positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43321804
167mannosylation (GO:0097502)2.42463434
168cellular response to interleukin-15 (GO:0071350)2.41905271
169rRNA methylation (GO:0031167)2.41650913
170tRNA processing (GO:0008033)2.41524482
171nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40723062
172meiotic chromosome segregation (GO:0045132)2.40512437
173ribosome biogenesis (GO:0042254)2.39411861
174base-excision repair, AP site formation (GO:0006285)2.36205193
175chromatin remodeling at centromere (GO:0031055)2.36093805
176transcription from RNA polymerase III promoter (GO:0006383)2.35681937
177poly(A)+ mRNA export from nucleus (GO:0016973)2.34387852
178protein-cofactor linkage (GO:0018065)2.33661364
179positive regulation of DNA-dependent DNA replication (GO:2000105)2.31429327
180negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.31315170
181deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.30187722
182positive regulation of DNA recombination (GO:0045911)2.28750913
183nucleotide-excision repair (GO:0006289)2.28138479
184regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.26923631
185mitotic G2/M transition checkpoint (GO:0044818)2.26302166
186reciprocal DNA recombination (GO:0035825)2.24521884
187reciprocal meiotic recombination (GO:0007131)2.24521884
188nucleotide-excision repair, DNA gap filling (GO:0006297)2.23366642
189regulation of mast cell activation (GO:0033003)2.23131520
190DNA biosynthetic process (GO:0071897)2.22646890
191regulation of alpha-beta T cell proliferation (GO:0046640)2.22526313
192DNA replication (GO:0006260)2.21869115
193centriole replication (GO:0007099)2.21168005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.45259003
2E2F7_22180533_ChIP-Seq_HELA_Human5.36669277
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.68720366
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31242204
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17714228
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63360573
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62231851
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52080002
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.39232431
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38353220
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.37866499
12GBX2_23144817_ChIP-Seq_PC3_Human2.35441577
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35206291
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33897116
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32540181
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30168276
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22875318
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18938927
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.16838160
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.16324142
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09089705
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08936778
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08763262
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03514402
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.03225117
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03225117
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99311850
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.97500132
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95526279
30IRF1_19129219_ChIP-ChIP_H3396_Human1.89638405
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88366996
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86234057
33* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85403520
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.81871003
35* VDR_23849224_ChIP-Seq_CD4+_Human1.81868856
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76781270
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76781270
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76781270
39ELK1_19687146_ChIP-ChIP_HELA_Human1.76501229
40AR_21909140_ChIP-Seq_LNCAP_Human1.72323825
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72116999
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66755876
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63286211
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.58605949
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57847015
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.56999361
47CBP_20019798_ChIP-Seq_JUKART_Human1.55444894
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55444894
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55169240
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54841990
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54785998
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.54604103
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54218269
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53058459
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.52799612
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.52798343
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52700777
58STAT3_23295773_ChIP-Seq_U87_Human1.50444904
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49402978
60SMAD4_21799915_ChIP-Seq_A2780_Human1.48705250
61TCF4_23295773_ChIP-Seq_U87_Human1.48038955
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.47382483
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47054570
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46950107
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46906759
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45365110
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45109466
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44911240
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.43912491
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43241504
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42673691
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40598254
73* FOXP3_21729870_ChIP-Seq_TREG_Human1.39779660
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.38591064
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38510254
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37998581
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37248347
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.34059031
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33026924
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32701595
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32263800
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31749575
83AR_25329375_ChIP-Seq_VCAP_Human1.31569105
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31521452
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30873756
86FUS_26573619_Chip-Seq_HEK293_Human1.30735421
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30244494
88* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29596905
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28925372
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28814557
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28776908
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28268520
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27525049
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25027069
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.24563553
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.24210970
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.24121956
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24040330
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23182758
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.22685282
101EWS_26573619_Chip-Seq_HEK293_Human1.22594975
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22470340
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.20288705
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.19645782
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19482368
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19419826
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.19405622
108P53_22387025_ChIP-Seq_ESCs_Mouse1.18378820
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.17944530
110IGF1R_20145208_ChIP-Seq_DFB_Human1.17855787
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16796550
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16595613
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15222221
114MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15068651
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14873689
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14736928
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14426425
118TAF15_26573619_Chip-Seq_HEK293_Human1.13832830
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13200459
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.13015451
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12520876
122MYC_18555785_ChIP-Seq_MESCs_Mouse1.11651080
123P300_18555785_Chip-Seq_ESCs_Mouse1.11483087
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10953175
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.10172423
126AHR_22903824_ChIP-Seq_MCF-7_Human1.10040751
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.09643334
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09634704
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09582690
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09341170
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.09323135
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09048960
133P300_19829295_ChIP-Seq_ESCs_Human1.08546663
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08526195
135ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08463367
136BP1_19119308_ChIP-ChIP_Hs578T_Human1.07206899
137CMYC_18555785_Chip-Seq_ESCs_Mouse1.06481000
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06464719
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05330600
140SMAD_19615063_ChIP-ChIP_OVARY_Human1.05270369
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04654923
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03858715
143OCT4_18555785_Chip-Seq_ESCs_Mouse1.03641626
144KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03260313
145FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02760380
146KDM2B_26808549_Chip-Seq_REH_Human1.02252263
147PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02040802
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01928017
149SOX2_21211035_ChIP-Seq_LN229_Gbm1.01731818
150KLF4_18555785_Chip-Seq_ESCs_Mouse1.01702839
151ZFX_18555785_Chip-Seq_ESCs_Mouse1.00916059
152GF1B_26923725_Chip-Seq_HPCs_Mouse1.00257361
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99932908
154WT1_19549856_ChIP-ChIP_CCG9911_Human0.99229143
155SALL4_22934838_ChIP-ChIP_CD34+_Human0.98990123
156PU1_27457419_Chip-Seq_LIVER_Mouse0.98810903
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98610904
158GF1_26923725_Chip-Seq_HPCs_Mouse0.98526577
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98282665
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.98172198
161ER_23166858_ChIP-Seq_MCF-7_Human0.98019184
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97718129
163* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97252117
164MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97198915
165ZNF274_21170338_ChIP-Seq_K562_Hela0.94660577
166WDR5_24793694_ChIP-Seq_LNCAP_Human0.92757980
167CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91580176
168SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91289462
169EP300_21415370_ChIP-Seq_HL-1_Mouse0.90540759
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88789266
171NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88754402
172FLI1_21867929_ChIP-Seq_TH2_Mouse0.88702531
173SOX9_26525672_Chip-Seq_HEART_Mouse0.87908322
174FOXO3_23340844_ChIP-Seq_DLD1_Human0.84586094
175RUNX_20019798_ChIP-Seq_JUKART_Human0.84181142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.16687934
2MP0003890_abnormal_embryonic-extraembry3.68792392
3MP0006292_abnormal_olfactory_placode3.52151693
4MP0008058_abnormal_DNA_repair3.17763856
5MP0005410_abnormal_fertilization2.69752942
6MP0005171_absent_coat_pigmentation2.60091147
7MP0003787_abnormal_imprinting2.59240580
8MP0001188_hyperpigmentation2.50209342
9MP0010386_abnormal_urinary_bladder2.48783601
10MP0001929_abnormal_gametogenesis2.48380737
11MP0008877_abnormal_DNA_methylation2.45112434
12MP0010094_abnormal_chromosome_stability2.44692519
13MP0005395_other_phenotype2.26708688
14MP0003111_abnormal_nucleus_morphology2.19581042
15MP0002163_abnormal_gland_morphology2.13946933
16MP0009697_abnormal_copulation2.13453123
17MP0005671_abnormal_response_to2.09938547
18MP0002009_preneoplasia2.09602521
19MP0010307_abnormal_tumor_latency2.08746802
20MP0000566_synostosis2.08382565
21MP0010234_abnormal_vibrissa_follicle2.06797912
22MP0000015_abnormal_ear_pigmentation2.05206459
23MP0001730_embryonic_growth_arrest2.04780119
24MP0003786_premature_aging2.02443906
25MP0003763_abnormal_thymus_physiology2.01636257
26MP0008007_abnormal_cellular_replicative1.99261810
27MP0003941_abnormal_skin_development1.91876195
28MP0001835_abnormal_antigen_presentation1.86046540
29MP0005646_abnormal_pituitary_gland1.84947327
30MP0003693_abnormal_embryo_hatching1.83837925
31MP0005075_abnormal_melanosome_morpholog1.77980338
32MP0001986_abnormal_taste_sensitivity1.77514083
33MP0003699_abnormal_female_reproductive1.74265620
34MP0003698_abnormal_male_reproductive1.72912349
35MP0008995_early_reproductive_senescence1.72817614
36MP0003077_abnormal_cell_cycle1.72154271
37MP0003121_genomic_imprinting1.64030169
38MP0002161_abnormal_fertility/fecundity1.59701298
39MP0003136_yellow_coat_color1.55784604
40MP0004381_abnormal_hair_follicle1.51491460
41MP0005380_embryogenesis_phenotype1.48745482
42MP0001672_abnormal_embryogenesis/_devel1.48745482
43MP0002277_abnormal_respiratory_mucosa1.48616959
44MP0005379_endocrine/exocrine_gland_phen1.48351690
45MP0005645_abnormal_hypothalamus_physiol1.47947446
46MP0003880_abnormal_central_pattern1.47668416
47MP0000653_abnormal_sex_gland1.44283882
48MP0003718_maternal_effect1.43078317
49MP0002148_abnormal_hypersensitivity_rea1.42422700
50MP0003183_abnormal_peptide_metabolism1.42376505
51MP0005076_abnormal_cell_differentiation1.41312785
52MP0009333_abnormal_splenocyte_physiolog1.37465713
53MP0003221_abnormal_cardiomyocyte_apopto1.36905215
54MP0005409_darkened_coat_color1.36662499
55MP0002095_abnormal_skin_pigmentation1.36068043
56MP0000350_abnormal_cell_proliferation1.33818766
57MP0010352_gastrointestinal_tract_polyps1.32384465
58MP0002876_abnormal_thyroid_physiology1.32178178
59MP0001145_abnormal_male_reproductive1.31768520
60MP0010678_abnormal_skin_adnexa1.26363394
61MP0000372_irregular_coat_pigmentation1.25876323
62MP0001529_abnormal_vocalization1.25301818
63MP0000427_abnormal_hair_cycle1.23531150
64MP0002132_abnormal_respiratory_system1.22464377
65MP0000569_abnormal_digit_pigmentation1.21872752
66MP0008789_abnormal_olfactory_epithelium1.20123606
67MP0002735_abnormal_chemical_nociception1.19124316
68MP0004270_analgesia1.19015036
69MP0002734_abnormal_mechanical_nocicepti1.18388839
70MP0005174_abnormal_tail_pigmentation1.16895367
71MP0002084_abnormal_developmental_patter1.15452826
72MP0001984_abnormal_olfaction1.12841122
73MP0001186_pigmentation_phenotype1.12463139
74MP0009785_altered_susceptibility_to1.12026098
75MP0003984_embryonic_growth_retardation1.11436291
76MP0001697_abnormal_embryo_size1.10833643
77MP0002088_abnormal_embryonic_growth/wei1.10283156
78MP0002127_abnormal_cardiovascular_syste1.09201547
79MP0005000_abnormal_immune_tolerance1.08820931
80MP0002085_abnormal_embryonic_tissue1.07184214
81MP0001119_abnormal_female_reproductive1.05855990
82MP0002233_abnormal_nose_morphology1.05161369
83MP0000538_abnormal_urinary_bladder1.04780194
84MP0004185_abnormal_adipocyte_glucose1.04486485
85MP0002938_white_spotting1.04484381
86MP0002396_abnormal_hematopoietic_system1.03934632
87MP0001293_anophthalmia1.03566169
88MP0004197_abnormal_fetal_growth/weight/1.03466720
89MP0002398_abnormal_bone_marrow1.02803719
90MP0002420_abnormal_adaptive_immunity1.00613358
91MP0001819_abnormal_immune_cell1.00407520
92MP0001800_abnormal_humoral_immune1.00003523
93MP0001790_abnormal_immune_system0.98986440
94MP0005387_immune_system_phenotype0.98986440
95MP0005394_taste/olfaction_phenotype0.98222798
96MP0005499_abnormal_olfactory_system0.98222798
97MP0002723_abnormal_immune_serum0.98182292
98MP0005423_abnormal_somatic_nervous0.97339990
99MP0008932_abnormal_embryonic_tissue0.96849606
100MP0001502_abnormal_circadian_rhythm0.95798757
101MP0003119_abnormal_digestive_system0.95306699
102MP0003868_abnormal_feces_composition0.95281024
103MP0002452_abnormal_antigen_presenting0.93498356
104MP0008260_abnormal_autophagy0.93304770
105MP0005310_abnormal_salivary_gland0.92142361
106MP0009703_decreased_birth_body0.91697624
107MP0002075_abnormal_coat/hair_pigmentati0.91275620
108MP0002080_prenatal_lethality0.90032907
109MP0001919_abnormal_reproductive_system0.89513446
110MP0002419_abnormal_innate_immunity0.89459414
111MP0000716_abnormal_immune_system0.88488048
112MP0009672_abnormal_birth_weight0.88222770
113MP0002210_abnormal_sex_determination0.88192907
114MP0005025_abnormal_response_to0.85582919
115MP0003935_abnormal_craniofacial_develop0.85573166
116MP0003861_abnormal_nervous_system0.84660087
117MP0002086_abnormal_extraembryonic_tissu0.84279714
118MP0001286_abnormal_eye_development0.83932085
119MP0002234_abnormal_pharynx_morphology0.83613180
120MP0003123_paternal_imprinting0.82567746
121MP0001486_abnormal_startle_reflex0.82384345
122MP0001346_abnormal_lacrimal_gland0.81808790
123MP0004957_abnormal_blastocyst_morpholog0.81256945
124MP0002006_tumorigenesis0.81047960
125MP0005389_reproductive_system_phenotype0.80362489
126MP0002102_abnormal_ear_morphology0.79898395
127MP0000778_abnormal_nervous_system0.79429571
128MP0002138_abnormal_hepatobiliary_system0.78766299
129MP0003724_increased_susceptibility_to0.78766130
130MP0001905_abnormal_dopamine_level0.78658358
131MP0000383_abnormal_hair_follicle0.77609048
132MP0000689_abnormal_spleen_morphology0.77086677
133MP0002405_respiratory_system_inflammati0.75371845
134MP0002796_impaired_skin_barrier0.75353973
135MP0002736_abnormal_nociception_after0.75175873
136MP0005621_abnormal_cell_physiology0.74407240
137MP0000313_abnormal_cell_death0.73759335
138MP0003755_abnormal_palate_morphology0.72737922
139MP0005408_hypopigmentation0.72535603
140MP0002067_abnormal_sensory_capabilities0.72210221
141MP0003635_abnormal_synaptic_transmissio0.71809086
142MP0000371_diluted_coat_color0.71320141
143MP0000703_abnormal_thymus_morphology0.70795304
144MP0004782_abnormal_surfactant_physiolog0.70747882
145MP0000026_abnormal_inner_ear0.70598542
146MP0004742_abnormal_vestibular_system0.69786391
147MP0002638_abnormal_pupillary_reflex0.69738516
148MP0002429_abnormal_blood_cell0.69721129
149MP0001963_abnormal_hearing_physiology0.68738634
150MP0004859_abnormal_synaptic_plasticity0.68647892
151MP0002751_abnormal_autonomic_nervous0.68138427
152MP0005384_cellular_phenotype0.67705644
153MP0000613_abnormal_salivary_gland0.67368169
154MP0000516_abnormal_urinary_system0.66891744
155MP0005367_renal/urinary_system_phenotyp0.66891744
156MP0002098_abnormal_vibrissa_morphology0.65072788
157MP0003879_abnormal_hair_cell0.63402287
158MP0000631_abnormal_neuroendocrine_gland0.62773942
159MP0009115_abnormal_fat_cell0.62607131
160MP0004811_abnormal_neuron_physiology0.61714103
161MP0000428_abnormal_craniofacial_morphol0.61555631
162MP0004233_abnormal_muscle_weight0.61289458
163MP0000733_abnormal_muscle_development0.61030111
164MP0001968_abnormal_touch/_nociception0.59049050
165MP0003567_abnormal_fetal_cardiomyocyte0.58159063
166MP0001915_intracranial_hemorrhage0.58090878
167MP0005647_abnormal_sex_gland0.57504760
168MP0002081_perinatal_lethality0.57332473
169MP0002139_abnormal_hepatobiliary_system0.55117559
170MP0000377_abnormal_hair_follicle0.55028112

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.14653350
2Facial hemangioma (HP:0000329)4.60511390
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.58363063
4Chromsome breakage (HP:0040012)4.14361515
5Truncal obesity (HP:0001956)3.63289642
6Birth length less than 3rd percentile (HP:0003561)3.47791440
7Abnormality of the preputium (HP:0100587)3.32775938
8Heterotopia (HP:0002282)3.30796522
9Supernumerary spleens (HP:0009799)3.22455664
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.21143823
11Meckel diverticulum (HP:0002245)3.13162750
12Thyroid carcinoma (HP:0002890)3.05450489
13Stomach cancer (HP:0012126)3.03977412
14Prostate neoplasm (HP:0100787)3.03084428
15Osteomalacia (HP:0002749)3.02398726
16Abnormality of chromosome stability (HP:0003220)2.99580069
17Abnormality of the ileum (HP:0001549)2.98194208
18Clubbing of toes (HP:0100760)2.95129941
19Type 2 muscle fiber atrophy (HP:0003554)2.94679742
20Abnormality of abdominal situs (HP:0011620)2.94096050
21Abdominal situs inversus (HP:0003363)2.94096050
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.89733530
23True hermaphroditism (HP:0010459)2.82384138
24Pancreatic fibrosis (HP:0100732)2.81048568
25Nephroblastoma (Wilms tumor) (HP:0002667)2.78038693
26Abnormality of chromosome segregation (HP:0002916)2.75763991
27Embryonal renal neoplasm (HP:0011794)2.70879918
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69263407
29Type I transferrin isoform profile (HP:0003642)2.68731673
30Hepatoblastoma (HP:0002884)2.67686357
31Abnormality of the prostate (HP:0008775)2.64550609
32Sensory axonal neuropathy (HP:0003390)2.58027176
33Ectopic kidney (HP:0000086)2.57392894
34Medial flaring of the eyebrow (HP:0010747)2.56431618
35Uterine leiomyosarcoma (HP:0002891)2.56022213
36Leiomyosarcoma (HP:0100243)2.56022213
37Duplicated collecting system (HP:0000081)2.55757507
38Transitional cell carcinoma of the bladder (HP:0006740)2.54919090
39Abnormal hair whorl (HP:0010721)2.53691574
40Abnormality of the renal collecting system (HP:0004742)2.52670818
41Rhabdomyosarcoma (HP:0002859)2.48333323
42Oligodactyly (hands) (HP:0001180)2.47595243
43Nephrogenic diabetes insipidus (HP:0009806)2.47062390
44Bladder carcinoma (HP:0002862)2.42874923
45Bladder neoplasm (HP:0009725)2.42874923
46Dysmetric saccades (HP:0000641)2.42763016
47Bone marrow hypocellularity (HP:0005528)2.41201821
48Capillary hemangiomas (HP:0005306)2.40684504
49Congenital primary aphakia (HP:0007707)2.38870676
50Hypoplastic labia majora (HP:0000059)2.38439487
51Muscle fiber atrophy (HP:0100295)2.37558192
52Retrobulbar optic neuritis (HP:0100654)2.37078050
53Optic neuritis (HP:0100653)2.37078050
54Impulsivity (HP:0100710)2.35576732
55Medulloblastoma (HP:0002885)2.34906031
56Increased nuchal translucency (HP:0010880)2.34802501
573-Methylglutaconic aciduria (HP:0003535)2.34699275
58Gait imbalance (HP:0002141)2.34565085
59Breast hypoplasia (HP:0003187)2.33739248
60Lower limb hyperreflexia (HP:0002395)2.31192061
61Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.28752920
62Gastrointestinal carcinoma (HP:0002672)2.27954443
63Malignant gastrointestinal tract tumors (HP:0006749)2.27954443
64High anterior hairline (HP:0009890)2.25653245
65Hypoplasia of the fovea (HP:0007750)2.25466877
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.25466877
67Pancreatic cysts (HP:0001737)2.23791968
68Cone-rod dystrophy (HP:0000548)2.22687808
69Abnormal lung lobation (HP:0002101)2.22459502
70Obsessive-compulsive behavior (HP:0000722)2.20740300
7111 pairs of ribs (HP:0000878)2.20278948
72Abnormal gallbladder physiology (HP:0012438)2.18685527
73Cholecystitis (HP:0001082)2.18685527
74Myelodysplasia (HP:0002863)2.17785658
75Apathy (HP:0000741)2.17703274
76Poor coordination (HP:0002370)2.16626167
77Aplasia/Hypoplasia of the sternum (HP:0006714)2.16594854
78Cafe-au-lait spot (HP:0000957)2.14596841
79Abnormality of the phalanges of the hallux (HP:0010057)2.12709371
80Duodenal stenosis (HP:0100867)2.12435992
81Small intestinal stenosis (HP:0012848)2.12435992
82Preaxial hand polydactyly (HP:0001177)2.10856538
83Abnormality of the labia majora (HP:0012881)2.09888655
84Premature graying of hair (HP:0002216)2.09562672
85Intestinal atresia (HP:0011100)2.08447083
86Abnormality of the septum pellucidum (HP:0007375)2.08011881
87Generalized hypopigmentation of hair (HP:0011358)2.06751786
88Abnormality of the fovea (HP:0000493)2.05864211
89Tubulointerstitial nephritis (HP:0001970)2.05281120
90Infertility (HP:0000789)2.04624420
91Patellar aplasia (HP:0006443)2.02992517
92Cortical dysplasia (HP:0002539)2.02622489
93Dysdiadochokinesis (HP:0002075)2.01972322
94Diminished motivation (HP:0000745)2.01574344
95Termporal pattern (HP:0011008)1.99323100
96Insidious onset (HP:0003587)1.99323100
97Acute myeloid leukemia (HP:0004808)1.99297985
98Median cleft lip (HP:0000161)1.98875800
99Febrile seizures (HP:0002373)1.97183370
100IgG deficiency (HP:0004315)1.96489790
101Anterior segment dysgenesis (HP:0007700)1.96138480
102Neoplasm of striated muscle (HP:0009728)1.95931493
103Hypothermia (HP:0002045)1.95746837
104Midline defect of the nose (HP:0004122)1.95555724
105Embryonal neoplasm (HP:0002898)1.95011297
106White forelock (HP:0002211)1.93116663
107Abnormality of the carotid arteries (HP:0005344)1.92784240
108Patchy hypopigmentation of hair (HP:0011365)1.92605385
109Lip pit (HP:0100267)1.92564793
110Hypophosphatemic rickets (HP:0004912)1.92328561
111Male infertility (HP:0003251)1.91059747
112Aganglionic megacolon (HP:0002251)1.90826659
113Fair hair (HP:0002286)1.89869957
114Cystic hygroma (HP:0000476)1.89059162
115Skull defect (HP:0001362)1.88389451
116Renal cell carcinoma (HP:0005584)1.86919215
117Abnormality of the labia minora (HP:0012880)1.86680900
118Abnormality of the columella (HP:0009929)1.86367573
119Aplasia/Hypoplasia of the patella (HP:0006498)1.85905200
120Drooling (HP:0002307)1.84389739
121Abnormality of male internal genitalia (HP:0000022)1.83324662
122Sloping forehead (HP:0000340)1.82964794
123IgM deficiency (HP:0002850)1.82944886
124Abnormal protein glycosylation (HP:0012346)1.82633736
125Abnormal glycosylation (HP:0012345)1.82633736
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82633736
127Abnormal protein N-linked glycosylation (HP:0012347)1.82633736
128Azoospermia (HP:0000027)1.80732488
129Protruding tongue (HP:0010808)1.80069330
130Postaxial foot polydactyly (HP:0001830)1.79958662
131Gaze-evoked nystagmus (HP:0000640)1.79259408
132Premature ovarian failure (HP:0008209)1.77703065
133Severe combined immunodeficiency (HP:0004430)1.77546892
134Complete atrioventricular canal defect (HP:0001674)1.77437950
135Abnormality of the duodenum (HP:0002246)1.77430253
136Neoplasm of the adrenal cortex (HP:0100641)1.77099962
137Optic nerve coloboma (HP:0000588)1.76978730
138Astigmatism (HP:0000483)1.76165556
139Recurrent abscess formation (HP:0002722)1.76125536
140Mediastinal lymphadenopathy (HP:0100721)1.76113522
141Tented upper lip vermilion (HP:0010804)1.74954349
142Decreased circulating renin level (HP:0003351)1.74531596
143Severe visual impairment (HP:0001141)1.73724372
144Amyotrophic lateral sclerosis (HP:0007354)1.73622689
145Urethral obstruction (HP:0000796)1.72944555
146Triphalangeal thumb (HP:0001199)1.72909463
147Excessive salivation (HP:0003781)1.72795227
148Choanal atresia (HP:0000453)1.72543249
149Recurrent pneumonia (HP:0006532)1.72499643
150Agnosia (HP:0010524)1.72172871
151Broad alveolar ridges (HP:0000187)1.72121004
152Biliary tract neoplasm (HP:0100574)1.72118047
153Abnormality of incisor morphology (HP:0011063)1.70509774
154Abnormality of the incisor (HP:0000676)1.70151731
155Orchitis (HP:0100796)1.69763016
156Aplastic anemia (HP:0001915)1.69693695
157Increased IgM level (HP:0003496)1.69129696
158Genital tract atresia (HP:0001827)1.68671356
159Chronic hepatic failure (HP:0100626)1.68573616
160Vaginal atresia (HP:0000148)1.68256639
161Hypergonadotropic hypogonadism (HP:0000815)1.66125236
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.64846734
163Optic nerve hypoplasia (HP:0000609)1.64506430
164Epileptic encephalopathy (HP:0200134)1.64082916
165Oligohydramnios (HP:0001562)1.64020641
166Alveolar cell carcinoma (HP:0006519)1.63323113
167Abnormal spermatogenesis (HP:0008669)1.62286400
168Lymphoma (HP:0002665)1.60404344
169Volvulus (HP:0002580)1.59343228
170Septo-optic dysplasia (HP:0100842)1.57236341
171Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57230960
172Pulmonary fibrosis (HP:0002206)1.57111500
173Carpal bone hypoplasia (HP:0001498)1.56859522
174Abnormality of the pons (HP:0007361)1.55636579
175Microvesicular hepatic steatosis (HP:0001414)1.54777288
176Flat capital femoral epiphysis (HP:0003370)1.53717694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.73059907
2ZAK3.55221205
3MAP3K93.31398908
4IRAK33.07059583
5CAMK1G2.87409843
6PLK42.87271209
7TRIM282.71773998
8CASK2.64499235
9BMPR22.62481860
10STK162.52907581
11SIK32.43784940
12MAP3K102.41612605
13SRPK12.36020895
14TXK2.26786151
15IRAK42.22723717
16MAP3K132.21787860
17MUSK2.03960236
18VRK12.01203699
19TNIK1.91928493
20YES11.87334777
21AKT31.86383824
22MKNK21.84933783
23WNK31.81177803
24CAMK1D1.79316985
25MAP3K141.76692913
26PRPF4B1.75184635
27EIF2AK21.75155317
28WNK11.74551686
29PINK11.72833272
30MAP3K41.70673883
31ERBB31.59692303
32SIK21.58532062
33MAP2K71.56884220
34KSR11.51711311
35NEK21.50645481
36NEK61.45073997
37ARAF1.43888308
38MKNK11.42992744
39RAF11.37935209
40SGK21.34229589
41TSSK61.34012145
42MST41.33610349
43BRAF1.32707457
44CDK91.31612824
45KSR21.25352037
46ATR1.24956096
47PLK31.23193803
48MAPK131.21314248
49IKBKB1.16043699
50BUB11.15953588
51LATS11.12358618
52CDK81.11647353
53CDK31.10584242
54EEF2K1.08139639
55GRK71.06663885
56MAP3K61.05626963
57GRK11.05593014
58MAP3K121.05578507
59BCR1.04521386
60EIF2AK31.04516069
61CDC71.01706154
62STK38L1.01427134
63NTRK21.00868974
64STK30.99861743
65AURKA0.99826436
66DYRK20.98402149
67NUAK10.96166667
68ADRBK20.92540425
69IRAK10.90485722
70IKBKE0.90437940
71MELK0.90324427
72BMPR1B0.89769785
73CLK10.88121090
74TEC0.87249192
75MARK10.87049183
76CHUK0.86421883
77JAK30.85879897
78TTK0.85099323
79MET0.82830698
80NLK0.82727035
81PASK0.82447428
82RPS6KB20.81335037
83CDK10.79813163
84CHEK20.79595428
85MTOR0.78088760
86PLK10.76975086
87WEE10.76728237
88BRD40.75437218
89MAP3K80.74298805
90TNK20.72878609
91SGK4940.72705437
92SGK2230.72705437
93IRAK20.69000258
94PLK20.68531189
95DAPK10.68290277
96STK240.66878735
97SGK30.66055021
98DYRK30.66018969
99CCNB10.65183337
100BRSK20.64889700
101ATM0.61902354
102ITK0.61060057
103DMPK0.60747085
104BTK0.60165420
105PNCK0.59332259
106PRKCI0.57583282
107PIM10.57045758
108STK40.56078450
109GSK3B0.53735845
110LYN0.52501389
111MAPK70.52466260
112RPS6KB10.52044394
113MAP4K20.49366462
114TAOK20.48842103
115CDK70.48753578
116STK380.48527342
117CSNK1E0.48234532
118CAMK40.47693482
119TAF10.47614094
120PBK0.47590802
121CHEK10.45318227
122TAOK30.45025338
123MAPK100.44775743
124CSNK1D0.43899591
125MAP4K10.43693366
126CDK190.43566509
127TRPM70.43089669
128SGK10.42902380
129ACVR1B0.41992607
130MOS0.41642113
131SYK0.41576082
132BRSK10.40473997
133PRKCZ0.39838192
134CSNK2A10.39751697
135PRKCE0.38352314
136LCK0.38115739
137PRKCD0.38062556
138EPHA20.38023018
139MAP2K40.37737525
140STK100.37722130
141CSNK1A10.36474818
142CSNK1G10.35236974
143FRK0.34754911
144MAP3K50.34452991
145AURKB0.34190109
146NME10.33181823
147MAPK10.33147897
148CDK20.32830385
149DYRK1A0.32764257
150PIM20.32530397
151CDK60.32213283

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.35427972
2Fanconi anemia pathway_Homo sapiens_hsa034603.05447202
3DNA replication_Homo sapiens_hsa030302.92732646
4Homologous recombination_Homo sapiens_hsa034402.77589630
5Base excision repair_Homo sapiens_hsa034102.59550455
6Dorso-ventral axis formation_Homo sapiens_hsa043202.58721063
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.46879963
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43633175
9Mismatch repair_Homo sapiens_hsa034302.40763362
10Graft-versus-host disease_Homo sapiens_hsa053322.30052980
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.30013356
12Oocyte meiosis_Homo sapiens_hsa041142.29306437
13Non-homologous end-joining_Homo sapiens_hsa034502.20172875
14Basal transcription factors_Homo sapiens_hsa030222.08527509
15Allograft rejection_Homo sapiens_hsa053302.02944473
16Protein export_Homo sapiens_hsa030601.99673080
17Pyrimidine metabolism_Homo sapiens_hsa002401.98229441
18RNA degradation_Homo sapiens_hsa030181.88217056
19Proteasome_Homo sapiens_hsa030501.82834069
20Autoimmune thyroid disease_Homo sapiens_hsa053201.81933970
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81347895
22Spliceosome_Homo sapiens_hsa030401.76026592
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69923088
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.67730840
25Inositol phosphate metabolism_Homo sapiens_hsa005621.59606611
26Nucleotide excision repair_Homo sapiens_hsa034201.57480182
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56517341
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52117047
29Purine metabolism_Homo sapiens_hsa002301.51033891
30Cell cycle_Homo sapiens_hsa041101.49076152
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47679612
32Endometrial cancer_Homo sapiens_hsa052131.43852173
33Primary immunodeficiency_Homo sapiens_hsa053401.43342607
34MicroRNAs in cancer_Homo sapiens_hsa052061.41543907
35Type I diabetes mellitus_Homo sapiens_hsa049401.38695068
36RNA transport_Homo sapiens_hsa030131.36487287
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.33726066
38Colorectal cancer_Homo sapiens_hsa052101.30807464
39Gap junction_Homo sapiens_hsa045401.29944615
40Prostate cancer_Homo sapiens_hsa052151.28983918
41Ovarian steroidogenesis_Homo sapiens_hsa049131.28800334
42Regulation of autophagy_Homo sapiens_hsa041401.28334087
43Thyroid cancer_Homo sapiens_hsa052161.28320490
44Non-small cell lung cancer_Homo sapiens_hsa052231.24127700
45mTOR signaling pathway_Homo sapiens_hsa041501.23376176
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20380084
47Measles_Homo sapiens_hsa051621.19248819
48Nicotine addiction_Homo sapiens_hsa050331.19223740
49Long-term potentiation_Homo sapiens_hsa047201.18045751
50ErbB signaling pathway_Homo sapiens_hsa040121.15305905
51One carbon pool by folate_Homo sapiens_hsa006701.12996020
52Renal cell carcinoma_Homo sapiens_hsa052111.12865065
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11927970
54Lysine degradation_Homo sapiens_hsa003101.11779656
55Olfactory transduction_Homo sapiens_hsa047401.11090560
56Pancreatic cancer_Homo sapiens_hsa052121.10956897
57Adherens junction_Homo sapiens_hsa045201.09899211
58Herpes simplex infection_Homo sapiens_hsa051681.08850402
59Acute myeloid leukemia_Homo sapiens_hsa052211.08390224
60Rheumatoid arthritis_Homo sapiens_hsa053231.07751036
61FoxO signaling pathway_Homo sapiens_hsa040681.07053812
62Chronic myeloid leukemia_Homo sapiens_hsa052201.06258637
63p53 signaling pathway_Homo sapiens_hsa041151.05828761
64Vitamin B6 metabolism_Homo sapiens_hsa007501.03049068
65Long-term depression_Homo sapiens_hsa047301.02179124
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01767908
67mRNA surveillance pathway_Homo sapiens_hsa030151.00777800
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00081736
69Steroid biosynthesis_Homo sapiens_hsa001000.99075280
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97593412
71Arachidonic acid metabolism_Homo sapiens_hsa005900.97165452
72Hematopoietic cell lineage_Homo sapiens_hsa046400.96358330
73B cell receptor signaling pathway_Homo sapiens_hsa046620.94884706
74Choline metabolism in cancer_Homo sapiens_hsa052310.94551809
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93796177
76Prolactin signaling pathway_Homo sapiens_hsa049170.93248368
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91694804
78Fatty acid biosynthesis_Homo sapiens_hsa000610.91447877
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91031966
80Glioma_Homo sapiens_hsa052140.90368651
81Viral carcinogenesis_Homo sapiens_hsa052030.89391875
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.88950729
83Other glycan degradation_Homo sapiens_hsa005110.86578659
84Ribosome_Homo sapiens_hsa030100.86031297
85Estrogen signaling pathway_Homo sapiens_hsa049150.84325783
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82113132
87Asthma_Homo sapiens_hsa053100.81799159
88Sphingolipid metabolism_Homo sapiens_hsa006000.81696932
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81341036
90Wnt signaling pathway_Homo sapiens_hsa043100.79707770
91Epstein-Barr virus infection_Homo sapiens_hsa051690.79684653
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78180572
93Taste transduction_Homo sapiens_hsa047420.77428767
94Type II diabetes mellitus_Homo sapiens_hsa049300.75335372
95Collecting duct acid secretion_Homo sapiens_hsa049660.75011624
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74717908
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74400857
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73371900
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.72266864
100Insulin signaling pathway_Homo sapiens_hsa049100.72252641
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72111296
102TGF-beta signaling pathway_Homo sapiens_hsa043500.72072794
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70674031
104Influenza A_Homo sapiens_hsa051640.70111254
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69366393
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69272365
107Notch signaling pathway_Homo sapiens_hsa043300.68769313
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64407721
109Legionellosis_Homo sapiens_hsa051340.64009705
110Phototransduction_Homo sapiens_hsa047440.63907984
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63726587
112GABAergic synapse_Homo sapiens_hsa047270.63233090
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63064965
114MAPK signaling pathway_Homo sapiens_hsa040100.61489788
115Glutamatergic synapse_Homo sapiens_hsa047240.61101547
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.60736429
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.60366888
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59189223
119Ether lipid metabolism_Homo sapiens_hsa005650.57338712
120Melanoma_Homo sapiens_hsa052180.57072170
121Serotonergic synapse_Homo sapiens_hsa047260.56552515
122Hippo signaling pathway_Homo sapiens_hsa043900.56398265
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56178011
124Antigen processing and presentation_Homo sapiens_hsa046120.55009291
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54838123
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54713641
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54549744
128Leishmaniasis_Homo sapiens_hsa051400.54243103
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.54050621
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54026636
131VEGF signaling pathway_Homo sapiens_hsa043700.53988430
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53415891
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52605072
134Oxytocin signaling pathway_Homo sapiens_hsa049210.52021808
135Oxidative phosphorylation_Homo sapiens_hsa001900.50421998
136Circadian rhythm_Homo sapiens_hsa047100.49840112
137Dopaminergic synapse_Homo sapiens_hsa047280.49183518
138Huntingtons disease_Homo sapiens_hsa050160.48528140
139T cell receptor signaling pathway_Homo sapiens_hsa046600.47713343
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.47168725
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46618592
142GnRH signaling pathway_Homo sapiens_hsa049120.46210599
143cAMP signaling pathway_Homo sapiens_hsa040240.46132693
144Vitamin digestion and absorption_Homo sapiens_hsa049770.45845327
145HIF-1 signaling pathway_Homo sapiens_hsa040660.45409991
146Morphine addiction_Homo sapiens_hsa050320.44561832
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44296862
148Small cell lung cancer_Homo sapiens_hsa052220.43301171
149Tight junction_Homo sapiens_hsa045300.42195411
150AMPK signaling pathway_Homo sapiens_hsa041520.42168001
151Systemic lupus erythematosus_Homo sapiens_hsa053220.42163829
152Phagosome_Homo sapiens_hsa041450.39746867
153Tuberculosis_Homo sapiens_hsa051520.38640339
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35638293
155Hepatitis C_Homo sapiens_hsa051600.34062799
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34042090
157Hepatitis B_Homo sapiens_hsa051610.33490615
158N-Glycan biosynthesis_Homo sapiens_hsa005100.32608439
159Apoptosis_Homo sapiens_hsa042100.32124751
160Chemokine signaling pathway_Homo sapiens_hsa040620.31321835
161African trypanosomiasis_Homo sapiens_hsa051430.29833706
162HTLV-I infection_Homo sapiens_hsa051660.27909921
163Pertussis_Homo sapiens_hsa051330.27607679
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27187671
165Synaptic vesicle cycle_Homo sapiens_hsa047210.26826674
166TNF signaling pathway_Homo sapiens_hsa046680.26071027
167Vibrio cholerae infection_Homo sapiens_hsa051100.25891723
168Malaria_Homo sapiens_hsa051440.25736488
169Linoleic acid metabolism_Homo sapiens_hsa005910.22343465
170Salmonella infection_Homo sapiens_hsa051320.22180117

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