PRDM11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.89993435
2doxorubicin metabolic process (GO:0044598)5.89993435
3daunorubicin metabolic process (GO:0044597)5.89993435
4response to pheromone (GO:0019236)3.96256640
5synaptic vesicle docking involved in exocytosis (GO:0016081)3.92774435
6regulation of non-canonical Wnt signaling pathway (GO:2000050)3.74758616
7inner ear receptor stereocilium organization (GO:0060122)3.73421681
8auditory receptor cell stereocilium organization (GO:0060088)3.66485033
9G-protein coupled receptor internalization (GO:0002031)3.60553071
10regulation of NFAT protein import into nucleus (GO:0051532)3.53364143
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52121692
12aminoglycoside antibiotic metabolic process (GO:0030647)3.46422697
13post-embryonic morphogenesis (GO:0009886)3.41012051
14head development (GO:0060322)3.38444735
15energy homeostasis (GO:0097009)3.38132228
16regulation of germinal center formation (GO:0002634)3.12242777
17cell communication by electrical coupling (GO:0010644)3.11335539
18detection of molecule of bacterial origin (GO:0032490)3.08153257
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.06495747
20righting reflex (GO:0060013)3.01958041
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99013951
22positive regulation of vascular permeability (GO:0043117)2.96233617
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91662816
24mesenchymal cell differentiation involved in kidney development (GO:0072161)2.89306675
25mesenchymal cell differentiation involved in renal system development (GO:2001012)2.89306675
26cerebellar granule cell differentiation (GO:0021707)2.89043198
27cardiac myofibril assembly (GO:0055003)2.84644469
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84389616
29negative regulation of dendrite morphogenesis (GO:0050774)2.82443411
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80576982
31lateral sprouting from an epithelium (GO:0060601)2.79977557
32cell migration in hindbrain (GO:0021535)2.79818958
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73249851
34negative regulation of translation, ncRNA-mediated (GO:0040033)2.72533088
35regulation of translation, ncRNA-mediated (GO:0045974)2.72533088
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72533088
37myofibril assembly (GO:0030239)2.70905778
38collecting duct development (GO:0072044)2.70330968
39muscle hypertrophy in response to stress (GO:0003299)2.69406873
40cardiac muscle adaptation (GO:0014887)2.69406873
41cardiac muscle hypertrophy in response to stress (GO:0014898)2.69406873
42regulation of somitogenesis (GO:0014807)2.69368292
43cerebral cortex radially oriented cell migration (GO:0021799)2.68586407
44potassium ion homeostasis (GO:0055075)2.67416398
45mesenchymal cell differentiation (GO:0048762)2.66755216
46sulfate transmembrane transport (GO:1902358)2.66185117
47negative regulation of granulocyte differentiation (GO:0030853)2.65668341
48cardiac muscle hypertrophy (GO:0003300)2.63757613
49female gonad development (GO:0008585)2.63502856
50startle response (GO:0001964)2.62063436
51extracellular regulation of signal transduction (GO:1900115)2.61248010
52extracellular negative regulation of signal transduction (GO:1900116)2.61248010
53myelination in peripheral nervous system (GO:0022011)2.59460017
54peripheral nervous system axon ensheathment (GO:0032292)2.59460017
55central nervous system projection neuron axonogenesis (GO:0021952)2.59058653
56cerebellar Purkinje cell differentiation (GO:0021702)2.58999850
57positive regulation of CREB transcription factor activity (GO:0032793)2.58433515
58vocalization behavior (GO:0071625)2.57724350
59glutamate secretion (GO:0014047)2.57414197
60cell communication involved in cardiac conduction (GO:0086065)2.57336170
61positive regulation by host of viral transcription (GO:0043923)2.56913615
62cell proliferation in forebrain (GO:0021846)2.56653674
63cell morphogenesis involved in neuron differentiation (GO:0048667)2.54240989
64dendritic spine morphogenesis (GO:0060997)2.52479204
65cellular anion homeostasis (GO:0030002)2.52459981
66striated muscle hypertrophy (GO:0014897)2.51486007
67histone H3-K4 trimethylation (GO:0080182)2.51053121
68postsynaptic membrane organization (GO:0001941)2.50068040
69regulation of short-term neuronal synaptic plasticity (GO:0048172)2.48352810
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.47609722
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47062781
72germinal center formation (GO:0002467)2.46482302
73drinking behavior (GO:0042756)2.45540437
74regulation of timing of cell differentiation (GO:0048505)2.45067360
75activation of protein kinase A activity (GO:0034199)2.44433156
76regulation of glutamate receptor signaling pathway (GO:1900449)2.42131122
77regulation of ARF GTPase activity (GO:0032312)2.40415420
78histone H3-K36 demethylation (GO:0070544)2.39152548
79cell-cell junction maintenance (GO:0045217)2.38123792
80ganglion development (GO:0061548)2.37896984
81positive regulation of Rap GTPase activity (GO:0032854)2.37462815
82synaptic vesicle maturation (GO:0016188)2.37185875
83membrane depolarization during action potential (GO:0086010)2.37020789
84cell proliferation involved in metanephros development (GO:0072203)2.36656612
85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.36501361
86positive regulation of vesicle fusion (GO:0031340)2.36464141
87dentate gyrus development (GO:0021542)2.35907798
88positive regulation of uterine smooth muscle contraction (GO:0070474)2.35732047
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.35131810
90negative regulation of stem cell proliferation (GO:2000647)2.35066832
91regulation of ARF protein signal transduction (GO:0032012)2.34813438
92cochlea development (GO:0090102)2.34595686
93cardiac muscle contraction (GO:0060048)2.33360155
94cell differentiation involved in kidney development (GO:0061005)2.32842535
95positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.32652668
96muscle hypertrophy (GO:0014896)2.31988923
97L-amino acid import (GO:0043092)2.31278102
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.31200685
99sodium ion export (GO:0071436)2.30347710
100sulfate transport (GO:0008272)2.30032378
101regulation of synaptic vesicle exocytosis (GO:2000300)2.29825729
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.29495388
103sarcomere organization (GO:0045214)2.29456762
104ionotropic glutamate receptor signaling pathway (GO:0035235)2.28785343
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28407623
106kidney morphogenesis (GO:0060993)2.28279023
107cellular response to epinephrine stimulus (GO:0071872)2.27419635
108neurotransmitter-gated ion channel clustering (GO:0072578)2.27138576
109negative regulation of keratinocyte proliferation (GO:0010839)2.26646275
110positive regulation of dendrite development (GO:1900006)2.26199293
111cranial nerve morphogenesis (GO:0021602)2.25197694
112adherens junction assembly (GO:0034333)2.25004389
113cranial nerve structural organization (GO:0021604)2.24385625
114adrenergic receptor signaling pathway (GO:0071875)2.23188481
115modulation by virus of host process (GO:0019054)2.23087509
116cell differentiation involved in metanephros development (GO:0072202)2.23037861
117metanephric mesenchyme development (GO:0072075)2.23024588
118positive regulation of synapse maturation (GO:0090129)2.22935440
119positive regulation of cellular amide metabolic process (GO:0034250)2.22395937
120negative regulation of erythrocyte differentiation (GO:0045647)2.21855195
121DNA integration (GO:0015074)2.21752348
122positive regulation of interleukin-1 beta secretion (GO:0050718)2.20838351
123opioid receptor signaling pathway (GO:0038003)2.20485138
124superoxide anion generation (GO:0042554)2.19323058
125cytoplasmic mRNA processing body assembly (GO:0033962)2.19265754
126negative regulation of osteoblast proliferation (GO:0033689)2.19239268
127sequestering of extracellular ligand from receptor (GO:0035581)2.19093032
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.18951173
129mesonephros development (GO:0001823)2.18768993
130detection of external biotic stimulus (GO:0098581)2.18370935
131regulation of voltage-gated calcium channel activity (GO:1901385)2.18319432
132regulation of actin filament-based movement (GO:1903115)2.18217862
133focal adhesion assembly (GO:0048041)2.17980083
134cell-substrate adherens junction assembly (GO:0007045)2.17980083
135auditory behavior (GO:0031223)2.17002802
136regulation of Rap GTPase activity (GO:0032317)2.16579573
137locomotory exploration behavior (GO:0035641)2.16542332
138embryonic camera-type eye morphogenesis (GO:0048596)2.16336977
139cell junction maintenance (GO:0034331)2.16271849
140regulation of cardiac muscle cell contraction (GO:0086004)2.15043751
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.15029198
142lateral ventricle development (GO:0021670)2.14442733
143positive regulation of action potential (GO:0045760)2.14272116
144regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.13987376
145positive regulation of cardiac muscle cell differentiation (GO:2000727)2.13729266
146glucocorticoid biosynthetic process (GO:0006704)2.13651635
147negative regulation of fatty acid transport (GO:2000192)2.13613527
148prostate gland growth (GO:0060736)2.13498659
149axon extension involved in axon guidance (GO:0048846)2.12794366
150neuron projection extension involved in neuron projection guidance (GO:1902284)2.12794366
151glomerulus development (GO:0032835)2.12459975
152regulation of dendrite morphogenesis (GO:0048814)2.12414258
153facial nerve structural organization (GO:0021612)2.11951443
154regulation of DNA endoreduplication (GO:0032875)2.11856949
155cell differentiation in hindbrain (GO:0021533)2.11284208
156bone trabecula formation (GO:0060346)2.11157558
157DNA strand renaturation (GO:0000733)2.11155580
158nerve growth factor signaling pathway (GO:0038180)2.11034258
159cellular sodium ion homeostasis (GO:0006883)2.11023616
160cellular potassium ion homeostasis (GO:0030007)2.10706459
161planar cell polarity pathway involved in neural tube closure (GO:0090179)2.10613428
162cell proliferation involved in kidney development (GO:0072111)2.10522796
163urinary tract smooth muscle contraction (GO:0014848)2.09839869
164reflex (GO:0060004)2.09777348
165protein targeting to plasma membrane (GO:0072661)2.09336613
166detection of calcium ion (GO:0005513)2.08955086
167layer formation in cerebral cortex (GO:0021819)2.08698422
168regulation of platelet aggregation (GO:0090330)2.08642225
169cardiac chamber formation (GO:0003207)2.08172579
170regulation of synapse structural plasticity (GO:0051823)2.07723996
171developmental pigmentation (GO:0048066)2.07408038
172glutamate receptor signaling pathway (GO:0007215)2.07018710
173insulin-like growth factor receptor signaling pathway (GO:0048009)2.06986602
174actomyosin structure organization (GO:0031032)2.06890908
175regulation of development, heterochronic (GO:0040034)2.06715634
176synaptic vesicle exocytosis (GO:0016079)2.05544028
177limb bud formation (GO:0060174)2.05412840
178negative regulation of axon guidance (GO:1902668)2.05203837
179establishment of nucleus localization (GO:0040023)2.05082570
180termination of G-protein coupled receptor signaling pathway (GO:0038032)2.04968085
181androgen biosynthetic process (GO:0006702)2.04761438
182regulation of neuronal synaptic plasticity (GO:0048168)2.04180085
183negative regulation of synaptic transmission, GABAergic (GO:0032229)2.04092676
184neuromuscular process controlling balance (GO:0050885)2.03037957
185Rap protein signal transduction (GO:0032486)2.02992466
186regulation of synapse maturation (GO:0090128)2.02594775
187G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.02303000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.06917576
2GBX2_23144817_ChIP-Seq_PC3_Human3.89058881
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69397051
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38398587
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35385533
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.31507258
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29489570
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25894464
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.14682075
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13638686
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08869471
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08254233
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04532668
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.02948548
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99430998
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99235440
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99235440
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98695620
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98036788
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95253560
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92902650
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90553447
23DROSHA_22980978_ChIP-Seq_HELA_Human1.90452329
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90423107
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90319345
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.87767313
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.87469874
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87355589
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84921846
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81734187
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.79855174
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.79356458
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.77826954
34* KDM2B_26808549_Chip-Seq_K562_Human1.76224619
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72629021
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72339233
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71445164
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.69373539
39P300_19829295_ChIP-Seq_ESCs_Human1.69349820
40IGF1R_20145208_ChIP-Seq_DFB_Human1.67365733
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67144325
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66639541
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.65302862
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64441252
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62225483
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61908643
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61157827
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.61082955
49AR_21572438_ChIP-Seq_LNCaP_Human1.60882332
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.59668832
51* NANOG_18555785_Chip-Seq_ESCs_Mouse1.57717231
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.57392562
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.56053735
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55879794
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55552156
56* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53551741
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.53297408
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53261641
59* E2F1_18555785_Chip-Seq_ESCs_Mouse1.53164498
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52902641
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.51747084
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51262619
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.50229079
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48871926
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47729232
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46995401
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.46130171
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46065960
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45839194
70TAF15_26573619_Chip-Seq_HEK293_Human1.44966654
71* P53_22387025_ChIP-Seq_ESCs_Mouse1.44663453
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43887675
73KDM2B_26808549_Chip-Seq_DND41_Human1.41561653
74* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41510418
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.40012421
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39798280
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39798280
78RNF2_27304074_Chip-Seq_NSC_Mouse1.39632720
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39394468
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.36942134
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.35433505
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35241616
83* CMYC_18555785_Chip-Seq_ESCs_Mouse1.34847366
84STAT3_23295773_ChIP-Seq_U87_Human1.33895022
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33503464
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33445679
87* STAT3_18555785_Chip-Seq_ESCs_Mouse1.32751834
88FUS_26573619_Chip-Seq_HEK293_Human1.31445037
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31127300
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30821937
91TP53_18474530_ChIP-ChIP_U2OS_Human1.30461943
92* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29290255
93AHR_22903824_ChIP-Seq_MCF-7_Human1.28548044
94* NMYC_18555785_Chip-Seq_ESCs_Mouse1.27872982
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27690980
96* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27558375
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27464338
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.27312043
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26785649
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26396428
101* P300_18555785_Chip-Seq_ESCs_Mouse1.25918702
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.25736649
103TCF4_23295773_ChIP-Seq_U87_Human1.25136569
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24258121
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23758271
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.21027027
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20839683
108* OCT4_18555785_Chip-Seq_ESCs_Mouse1.20423435
109EWS_26573619_Chip-Seq_HEK293_Human1.19701365
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19061113
111PU1_27457419_Chip-Seq_LIVER_Mouse1.18956575
112* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18008941
113* SOX2_18555785_Chip-Seq_ESCs_Mouse1.17370990
114VDR_22108803_ChIP-Seq_LS180_Human1.17171256
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.16850318
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16772214
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15616772
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15388465
119* RUNX2_22187159_ChIP-Seq_PCA_Human1.15158602
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15087917
121* REST_21632747_ChIP-Seq_MESCs_Mouse1.14981659
122AR_25329375_ChIP-Seq_VCAP_Human1.14610791
123* ZFX_18555785_Chip-Seq_ESCs_Mouse1.14014332
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14005667
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13627293
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13550932
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13476604
128* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13209923
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13176022
130FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11239187
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10997109
132* AR_19668381_ChIP-Seq_PC3_Human1.10818130
133KLF4_18555785_Chip-Seq_ESCs_Mouse1.10562087
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09981159
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.09602502
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09398105
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09171639
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08093908
139ER_23166858_ChIP-Seq_MCF-7_Human1.07651364
140TRIM28_21343339_ChIP-Seq_HEK293_Human1.03666550
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02852010
142ESR1_21235772_ChIP-Seq_MCF-7_Human1.01322425
143TBX20_22328084_ChIP-Seq_HEART_Mouse1.00688357
144TBX20_22080862_ChIP-Seq_HEART_Mouse1.00688357
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00435160
146TP53_23651856_ChIP-Seq_MEFs_Mouse0.99786619
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.99619871
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98102566
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.97564624
150LXR_22292898_ChIP-Seq_THP-1_Human0.97415008
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.94936195
152CTCF_27219007_Chip-Seq_Bcells_Human0.94168549
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93787031
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92833433
155GATA1_19941826_ChIP-Seq_K562_Human0.92741401
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.92241068
157RXR_22108803_ChIP-Seq_LS180_Human0.91485884
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90924355
159ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90757442
160TP53_16413492_ChIP-PET_HCT116_Human0.89494346
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88713834
162* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86561283
163CREB1_26743006_Chip-Seq_LNCaP_Human0.85781956
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.85656398
165REST_18959480_ChIP-ChIP_MESCs_Mouse0.84488263
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.84307153
167GATA1_26923725_Chip-Seq_HPCs_Mouse0.83569521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.69626606
2MP0000566_synostosis3.62652726
3MP0006292_abnormal_olfactory_placode2.95112883
4MP0005645_abnormal_hypothalamus_physiol2.74072705
5MP0003705_abnormal_hypodermis_morpholog2.47252892
6MP0004084_abnormal_cardiac_muscle2.46289806
7MP0003878_abnormal_ear_physiology2.45931848
8MP0005377_hearing/vestibular/ear_phenot2.45931848
9MP0010368_abnormal_lymphatic_system2.43714170
10MP0002102_abnormal_ear_morphology2.39250667
11MP0008438_abnormal_cutaneous_collagen2.36573924
12MP0000569_abnormal_digit_pigmentation2.36050431
13MP0000751_myopathy2.35193526
14MP0003941_abnormal_skin_development2.31369219
15MP0005275_abnormal_skin_tensile2.28735686
16MP0001486_abnormal_startle_reflex2.23517991
17MP0003122_maternal_imprinting2.07279012
18MP0005409_darkened_coat_color2.02385848
19MP0005171_absent_coat_pigmentation2.01375630
20MP0004036_abnormal_muscle_relaxation2.01013512
21MP0002277_abnormal_respiratory_mucosa1.98856296
22MP0000383_abnormal_hair_follicle1.91564430
23MP0004270_analgesia1.91244095
24MP0002938_white_spotting1.90455203
25MP0003787_abnormal_imprinting1.85353325
26MP0004130_abnormal_muscle_cell1.82184305
27MP0002064_seizures1.82181326
28MP0008004_abnormal_stomach_pH1.80175876
29MP0001986_abnormal_taste_sensitivity1.75891603
30MP0005423_abnormal_somatic_nervous1.75254731
31MP0004742_abnormal_vestibular_system1.69107316
32MP0000049_abnormal_middle_ear1.68643704
33MP0004859_abnormal_synaptic_plasticity1.66844116
34MP0002249_abnormal_larynx_morphology1.66694745
35MP0006138_congestive_heart_failure1.66407796
36MP0005646_abnormal_pituitary_gland1.64207361
37MP0000733_abnormal_muscle_development1.61493589
38MP0005503_abnormal_tendon_morphology1.57835208
39MP0004087_abnormal_muscle_fiber1.54990720
40MP0010630_abnormal_cardiac_muscle1.54625264
41MP0008569_lethality_at_weaning1.49619463
42MP0002108_abnormal_muscle_morphology1.48846065
43MP0002735_abnormal_chemical_nociception1.47301908
44MP0000678_abnormal_parathyroid_gland1.46152868
45MP0003880_abnormal_central_pattern1.46022469
46MP0004510_myositis1.44536612
47MP0004215_abnormal_myocardial_fiber1.44172041
48MP0000026_abnormal_inner_ear1.44034489
49MP0003136_yellow_coat_color1.39584909
50MP0000015_abnormal_ear_pigmentation1.39204641
51MP0009046_muscle_twitch1.38129967
52MP0002734_abnormal_mechanical_nocicepti1.37657089
53MP0009250_abnormal_appendicular_skeleto1.34172068
54MP0005620_abnormal_muscle_contractility1.33228742
55MP0009780_abnormal_chondrocyte_physiolo1.32425567
56MP0003879_abnormal_hair_cell1.31370701
57MP0005174_abnormal_tail_pigmentation1.29709589
58MP0001346_abnormal_lacrimal_gland1.28300654
59MP0002009_preneoplasia1.27989205
60MP0001958_emphysema1.27032337
61MP0000749_muscle_degeneration1.25911381
62MP0006276_abnormal_autonomic_nervous1.25901446
63MP0002396_abnormal_hematopoietic_system1.25292877
64MP0003121_genomic_imprinting1.25050882
65MP0000631_abnormal_neuroendocrine_gland1.24120264
66MP0001970_abnormal_pain_threshold1.23765821
67MP0003385_abnormal_body_wall1.22822869
68MP0003091_abnormal_cell_migration1.22165684
69MP0009745_abnormal_behavioral_response1.21737287
70MP0002557_abnormal_social/conspecific_i1.21350344
71MP0005379_endocrine/exocrine_gland_phen1.21193923
72MP0009697_abnormal_copulation1.19305371
73MP0000534_abnormal_ureter_morphology1.18247359
74MP0001963_abnormal_hearing_physiology1.17756656
75MP0002572_abnormal_emotion/affect_behav1.16177838
76MP0004145_abnormal_muscle_electrophysio1.16076043
77MP0005330_cardiomyopathy1.14812893
78MP0002184_abnormal_innervation1.13442396
79MP0002233_abnormal_nose_morphology1.13246759
80MP0002733_abnormal_thermal_nociception1.12291810
81MP0001485_abnormal_pinna_reflex1.11752830
82MP0002972_abnormal_cardiac_muscle1.11436825
83MP0003115_abnormal_respiratory_system1.10838704
84MP0004272_abnormal_basement_membrane1.10446698
85MP0003938_abnormal_ear_development1.10268141
86MP0001968_abnormal_touch/_nociception1.09946273
87MP0003935_abnormal_craniofacial_develop1.08698251
88MP0000762_abnormal_tongue_morphology1.08099606
89MP0003635_abnormal_synaptic_transmissio1.07742236
90MP0000778_abnormal_nervous_system1.07618003
91MP0002116_abnormal_craniofacial_bone1.06306178
92MP0001293_anophthalmia1.05049634
93MP0004381_abnormal_hair_follicle1.05006744
94MP0001177_atelectasis1.04837438
95MP0002067_abnormal_sensory_capabilities1.02383575
96MP0002177_abnormal_outer_ear1.01408846
97MP0003172_abnormal_lysosome_physiology1.00203648
98MP0001879_abnormal_lymphatic_vessel0.99220132
99MP0005257_abnormal_intraocular_pressure0.98722366
100MP0000579_abnormal_nail_morphology0.98372935
101MP0000759_abnormal_skeletal_muscle0.98090318
102MP0003279_aneurysm0.97945754
103MP0001501_abnormal_sleep_pattern0.97671894
104MP0005623_abnormal_meninges_morphology0.97462731
105MP0000767_abnormal_smooth_muscle0.96400526
106MP0002925_abnormal_cardiovascular_devel0.96357220
107MP0002109_abnormal_limb_morphology0.95314544
108MP0008995_early_reproductive_senescence0.93633945
109MP0005369_muscle_phenotype0.93576558
110MP0005551_abnormal_eye_electrophysiolog0.93308172
111MP0003755_abnormal_palate_morphology0.92974401
112MP0000747_muscle_weakness0.90407436
113MP0000427_abnormal_hair_cycle0.90268414
114MP0001984_abnormal_olfaction0.90019698
115MP0000613_abnormal_salivary_gland0.90003096
116MP0004484_altered_response_of0.89514666
117MP0002095_abnormal_skin_pigmentation0.89415355
118MP0005595_abnormal_vascular_smooth0.88156836
119MP0002736_abnormal_nociception_after0.87622731
120MP0009703_decreased_birth_body0.87249116
121MP0004134_abnormal_chest_morphology0.86828985
122MP0001502_abnormal_circadian_rhythm0.86375387
123MP0000266_abnormal_heart_morphology0.85916573
124MP0002106_abnormal_muscle_physiology0.84666280
125MP0002272_abnormal_nervous_system0.84603575
126MP0001270_distended_abdomen0.84514967
127MP0010678_abnormal_skin_adnexa0.84144535
128MP0002163_abnormal_gland_morphology0.84111706
129MP0003566_abnormal_cell_adhesion0.83172677
130MP0003937_abnormal_limbs/digits/tail_de0.81989557
131MP0000681_abnormal_thyroid_gland0.81653781
132MP0005385_cardiovascular_system_phenoty0.80850621
133MP0001544_abnormal_cardiovascular_syste0.80850621
134MP0000470_abnormal_stomach_morphology0.80504482
135MP0002063_abnormal_learning/memory/cond0.80479090
136MP0002127_abnormal_cardiovascular_syste0.80171221
137MP0000537_abnormal_urethra_morphology0.79907899
138MP0010386_abnormal_urinary_bladder0.79900919
139MP0000013_abnormal_adipose_tissue0.79400495
140MP0008058_abnormal_DNA_repair0.78875809
141MP0006072_abnormal_retinal_apoptosis0.78679830
142MP0005167_abnormal_blood-brain_barrier0.78650199
143MP0001299_abnormal_eye_distance/0.78448724
144MP0002089_abnormal_postnatal_growth/wei0.78429464
145MP0003634_abnormal_glial_cell0.77978120
146MP0000428_abnormal_craniofacial_morphol0.77916021
147MP0005220_abnormal_exocrine_pancreas0.77412895
148MP0002752_abnormal_somatic_nervous0.76663197
149MP0004264_abnormal_extraembryonic_tissu0.76389214
150MP0002066_abnormal_motor_capabilities/c0.76269026
151MP0002332_abnormal_exercise_endurance0.75845968
152MP0003329_amyloid_beta_deposits0.75746940
153MP0003633_abnormal_nervous_system0.75682814
154MP0003283_abnormal_digestive_organ0.74659000
155MP0000432_abnormal_head_morphology0.74606551
156MP0002128_abnormal_blood_circulation0.74528080
157MP0002075_abnormal_coat/hair_pigmentati0.74367602
158MP0005248_abnormal_Harderian_gland0.73485175
159MP0004811_abnormal_neuron_physiology0.72348845
160MP0000955_abnormal_spinal_cord0.71814035
161MP0004808_abnormal_hematopoietic_stem0.71770932
162MP0000462_abnormal_digestive_system0.71706408
163MP0002837_dystrophic_cardiac_calcinosis0.70842276
164MP0001286_abnormal_eye_development0.69820809
165MP0004085_abnormal_heartbeat0.69580268
166MP0002932_abnormal_joint_morphology0.68912502
167MP0003045_fibrosis0.68775018
168MP0003942_abnormal_urinary_system0.68616162
169MP0003828_pulmonary_edema0.68214412

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.45223592
2Chromsome breakage (HP:0040012)4.71436186
3Febrile seizures (HP:0002373)4.09380562
4Prostate neoplasm (HP:0100787)3.68265278
5Obstructive sleep apnea (HP:0002870)3.51182313
6Genetic anticipation (HP:0003743)3.48489676
7Absent eyebrow (HP:0002223)3.37044335
8Absent/shortened dynein arms (HP:0200106)3.31638987
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.31638987
10Congenital stationary night blindness (HP:0007642)3.20043174
11Upper limb muscle weakness (HP:0003484)3.12039218
12Atonic seizures (HP:0010819)3.10116329
13Dysmetric saccades (HP:0000641)3.04321867
14Midline defect of the nose (HP:0004122)3.03311101
15Abnormality of the renal collecting system (HP:0004742)3.01633105
16Duplicated collecting system (HP:0000081)2.99906862
17Unilateral renal agenesis (HP:0000122)2.99203584
18Sudden death (HP:0001699)2.69564706
19Prolonged QT interval (HP:0001657)2.66713622
20Bronchomalacia (HP:0002780)2.63562755
21Aplasia cutis congenita (HP:0001057)2.61233185
22Aortic aneurysm (HP:0004942)2.59291767
23Abnormality of the fingertips (HP:0001211)2.54143332
24Follicular hyperkeratosis (HP:0007502)2.52074140
25Cerebral aneurysm (HP:0004944)2.50866616
26Distal arthrogryposis (HP:0005684)2.48381191
27Mesomelia (HP:0003027)2.47210714
28Action tremor (HP:0002345)2.46527787
29Narrow palate (HP:0000189)2.45658753
30Abnormality of the parietal bone (HP:0002696)2.45618145
31Neoplasm of the heart (HP:0100544)2.45451151
32Congenital sensorineural hearing impairment (HP:0008527)2.45333467
33Focal seizures (HP:0007359)2.44420193
34Abnormality of incisor morphology (HP:0011063)2.41199944
35White forelock (HP:0002211)2.38681862
36Abnormal ciliary motility (HP:0012262)2.38121988
37Hemorrhage of the eye (HP:0011885)2.35178866
38Ectopic kidney (HP:0000086)2.33530181
39Parakeratosis (HP:0001036)2.33437295
40Abnormality of the nasal septum (HP:0000419)2.33291070
41Septo-optic dysplasia (HP:0100842)2.32874466
42Hyporeflexia of lower limbs (HP:0002600)2.31145372
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.30917925
44Supernumerary nipples (HP:0002558)2.30137382
45Round ear (HP:0100830)2.28171239
46Annular pancreas (HP:0001734)2.27923824
47Focal motor seizures (HP:0011153)2.24674700
48Urinary bladder sphincter dysfunction (HP:0002839)2.23980554
49Shallow orbits (HP:0000586)2.22288207
50Mitral valve prolapse (HP:0001634)2.22185786
51Cutaneous finger syndactyly (HP:0010554)2.21830709
52Patchy hypopigmentation of hair (HP:0011365)2.21096938
53Ankle clonus (HP:0011448)2.18236555
54Renal dysplasia (HP:0000110)2.16338160
55Chronic hepatic failure (HP:0100626)2.13260811
56Nephroblastoma (Wilms tumor) (HP:0002667)2.12965251
57Abnormality of the carotid arteries (HP:0005344)2.12887970
58Meckel diverticulum (HP:0002245)2.11153528
59Syncope (HP:0001279)2.10938856
60Difficulty running (HP:0009046)2.10409078
61Clumsiness (HP:0002312)2.09695276
62Clubbing of toes (HP:0100760)2.08097048
63Abnormality of the right ventricle (HP:0001707)2.08022335
64Abnormality of DNA repair (HP:0003254)2.07178937
65Absence seizures (HP:0002121)2.06745835
66Abnormality of the ileum (HP:0001549)2.03771004
67Tracheomalacia (HP:0002779)2.02660346
68Morphological abnormality of the middle ear (HP:0008609)2.02022128
69Embryonal renal neoplasm (HP:0011794)2.01736238
70Aortic dissection (HP:0002647)2.01584705
71Short chin (HP:0000331)2.01493098
72Dislocated radial head (HP:0003083)2.01108331
73Bilateral sensorineural hearing impairment (HP:0008619)2.00528621
74Absent eyelashes (HP:0000561)1.99761177
75Abnormal respiratory epithelium morphology (HP:0012253)1.99543732
76Abnormal respiratory motile cilium morphology (HP:0005938)1.99543732
77Broad face (HP:0000283)1.99441803
78Cheilitis (HP:0100825)1.98817977
79Duplication of thumb phalanx (HP:0009942)1.98619251
80Truncal ataxia (HP:0002078)1.98213713
81Abnormality of the preputium (HP:0100587)1.97531750
82Turricephaly (HP:0000262)1.96295861
83Thickened helices (HP:0000391)1.94860590
84Muscle fiber splitting (HP:0003555)1.94356154
85Progressive cerebellar ataxia (HP:0002073)1.94312958
86Abnormality of the radial head (HP:0003995)1.92886978
87Primary atrial arrhythmia (HP:0001692)1.92858578
88Cutaneous syndactyly (HP:0012725)1.91086501
89Ulnar deviation of the wrist (HP:0003049)1.91005071
90Osteomalacia (HP:0002749)1.90367449
91Generalized tonic-clonic seizures (HP:0002069)1.89045873
92Abnormal EKG (HP:0003115)1.88713106
93Fragile skin (HP:0001030)1.88324458
94Broad metatarsal (HP:0001783)1.87593510
95Aneurysm (HP:0002617)1.87374239
96Soft skin (HP:0000977)1.86605844
97Bundle branch block (HP:0011710)1.85768943
98Protruding tongue (HP:0010808)1.84909649
99Limited hip movement (HP:0008800)1.84642312
100Elfin facies (HP:0004428)1.83921184
101Hip contracture (HP:0003273)1.83191427
102Wide anterior fontanel (HP:0000260)1.82707086
103Pulmonary artery stenosis (HP:0004415)1.81604943
104Dialeptic seizures (HP:0011146)1.80259688
105Atrioventricular block (HP:0001678)1.80152593
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79647983
107Short 4th metacarpal (HP:0010044)1.79647983
108Lymphangioma (HP:0100764)1.78822585
109Alopecia of scalp (HP:0002293)1.78316300
110Abnormality of the prostate (HP:0008775)1.77907836
111Diplopia (HP:0000651)1.77726903
112Abnormality of binocular vision (HP:0011514)1.77726903
113Hyperventilation (HP:0002883)1.77304085
114Decreased central vision (HP:0007663)1.76306869
115Abnormal respiratory motile cilium physiology (HP:0012261)1.75309708
116Lower limb amyotrophy (HP:0007210)1.75060034
117Recurrent corneal erosions (HP:0000495)1.74871966
118Absent speech (HP:0001344)1.73281477
119Deeply set eye (HP:0000490)1.73199213
120Hemiplegia (HP:0002301)1.72545138
121Back pain (HP:0003418)1.72401066
122Supraventricular tachycardia (HP:0004755)1.72155914
123Supraventricular arrhythmia (HP:0005115)1.72009368
124Broad-based gait (HP:0002136)1.70607524
125Pointed chin (HP:0000307)1.69940661
126Ventricular fibrillation (HP:0001663)1.69885339
127Optic nerve hypoplasia (HP:0000609)1.69696192
128Thick eyebrow (HP:0000574)1.69605129
129Flat cornea (HP:0007720)1.68758859
130Abnormality of the nasolacrimal system (HP:0000614)1.67408782
131Ulnar bowing (HP:0003031)1.67162568
132Abnormality of the left ventricular outflow tract (HP:0011103)1.67115503
133Subaortic stenosis (HP:0001682)1.67115503
134Abnormality of the incisor (HP:0000676)1.66660463
135Arterial tortuosity (HP:0005116)1.66044242
136Hyperphosphatemia (HP:0002905)1.65705460
137Lip pit (HP:0100267)1.64930103
138Macroorchidism (HP:0000053)1.64636226
139Distal lower limb amyotrophy (HP:0008944)1.64576817
140Hyperextensible skin (HP:0000974)1.63840341
141Abnormality of the lacrimal duct (HP:0011481)1.63807668
142Nephronophthisis (HP:0000090)1.63797342
143Protrusio acetabuli (HP:0003179)1.63717617
144Exercise-induced myalgia (HP:0003738)1.63197156
145Spastic gait (HP:0002064)1.63040277
146Tetany (HP:0001281)1.62802363
147Abnormality of the renal medulla (HP:0100957)1.62461598
148Renal duplication (HP:0000075)1.62318432
149Overgrowth (HP:0001548)1.62167128
150Asymmetry of the thorax (HP:0001555)1.61583877
151Mitral regurgitation (HP:0001653)1.61306790
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60916078
153Papilledema (HP:0001085)1.60018100
154Anal stenosis (HP:0002025)1.59846891
155Aplasia involving bones of the extremities (HP:0009825)1.59400763
156Aplasia involving bones of the upper limbs (HP:0009823)1.59400763
157Aplasia of the phalanges of the hand (HP:0009802)1.59400763
158Metatarsus adductus (HP:0001840)1.59162196
159Neurofibrillary tangles (HP:0002185)1.59110457
160Spina bifida occulta (HP:0003298)1.58519035
161Hyperacusis (HP:0010780)1.58402666
162Alveolar cell carcinoma (HP:0006519)1.58086964
163Atrial fibrillation (HP:0005110)1.56752458
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55374644
165Thin ribs (HP:0000883)1.55267678
166Hypoplasia of the iris (HP:0007676)1.55120379
167Bell-shaped thorax (HP:0001591)1.54781211
168Renal agenesis (HP:0000104)1.54726631
169Renovascular hypertension (HP:0100817)1.54498528
170Optic neuritis (HP:0100653)1.54149742
171Retrobulbar optic neuritis (HP:0100654)1.54149742
172Chronic otitis media (HP:0000389)1.52862835
173Acute lymphatic leukemia (HP:0006721)1.52759684
174Abnormality of the intervertebral disk (HP:0005108)1.51601681
175Distal lower limb muscle weakness (HP:0009053)1.51446064
176Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.51089528
177Trigonocephaly (HP:0000243)1.50958984
178Stomach cancer (HP:0012126)1.50935969
179Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.50245072
180Omphalocele (HP:0001539)1.50239649
181Long eyelashes (HP:0000527)1.49795507
182Increased number of teeth (HP:0011069)1.49661116
183Absent hair (HP:0002298)1.48643383
184Epileptic encephalopathy (HP:0200134)1.47905808
185Keratoconus (HP:0000563)1.46893972
186Increased corneal curvature (HP:0100692)1.46893972
187Renal cortical cysts (HP:0000803)1.46585243
188Widely spaced teeth (HP:0000687)1.46570416
189Exotropia (HP:0000577)1.45958629
190Nasolacrimal duct obstruction (HP:0000579)1.44126008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.22850180
2MAP3K103.86466941
3CASK3.58353498
4TNIK3.44482947
5SIK23.09268736
6TRIB32.86189297
7RIPK12.70507110
8INSRR2.68966133
9GRK12.57348106
10NTRK32.40302756
11EEF2K2.36056795
12ICK2.34794869
13EIF2AK22.34356082
14ZAK2.12792127
15PRPF4B2.09527727
16TXK2.09340727
17SIK12.01188968
18MAP3K141.82596354
19DAPK21.67797668
20SGK21.59431135
21ADRBK21.59410473
22TTN1.55545359
23MAP3K131.54411368
24MAPK131.53763729
25BRD41.52742975
26MAP2K71.49646588
27LATS21.47405231
28EPHA31.46418647
29TYRO31.39270889
30RPS6KA21.37347691
31LATS11.37295785
32CDK31.34192585
33YES11.28955624
34CAMK1G1.26145793
35PRKD31.25812450
36CDK81.20729299
37MTOR1.19597360
38TNK21.18944522
39CAMK1D1.18713557
40NTRK11.18670963
41UHMK11.18210343
42BMPR1B1.18059373
43HIPK21.15937932
44NEK61.14560030
45CAMKK11.14024382
46MKNK21.12646692
47AKT31.08873793
48MARK31.08554958
49SGK31.04805324
50EPHB21.01964387
51RPS6KL11.01687896
52RPS6KC11.01687896
53CAMK11.01647153
54MUSK1.01192249
55MARK21.00742330
56PKN10.97719166
57TEC0.96440726
58PDGFRA0.95557027
59NUAK10.93551039
60NTRK20.93313733
61EPHA40.91457638
62MAP3K70.91079889
63WNK10.90902815
64STK38L0.90448470
65CAMK40.89174788
66RPS6KA60.88375072
67GRK70.88112018
68SGK4940.88001333
69SGK2230.88001333
70PAK60.86701697
71TAOK20.85393796
72FGFR30.84288896
73PRKAA20.82839671
74PRKCE0.82593872
75SGK10.82564448
76MAPK100.80429854
77MAPK70.78695202
78TIE10.78482491
79CDC42BPA0.76782874
80CDK120.76427387
81MAP2K20.75171485
82STK160.74957871
83JAK10.74287646
84RET0.73079226
85FRK0.72679527
86PKN20.71351909
87IRAK40.70628008
88MARK10.68537551
89SRPK10.67912962
90CDK60.67905353
91STK240.65834155
92CDK50.65569497
93DMPK0.64543545
94NLK0.64111795
95TGFBR20.63685626
96OBSCN0.63296792
97KSR20.62974787
98PNCK0.62692822
99MAP3K90.62142034
100FGFR40.61659419
101ERBB30.60381695
102PIK3CA0.60164628
103CLK10.59059447
104PLK20.58939643
105PDPK10.58902696
106CHUK0.57470489
107TRPM70.55465995
108PRKD20.55393203
109MAPK150.54767064
110BRAF0.54478893
111PRKG10.54099035
112MAP3K10.53841280
113MAP2K40.53328270
114BMPR20.52784645
115DDR20.52303303
116KIT0.52074368
117PDGFRB0.50524739
118RPS6KA30.50482541
119ROCK10.50181660
120SMG10.48873056
121MAP3K40.48699236
122MKNK10.48319892
123MAP3K60.48066495
124HCK0.47622543
125IRAK10.47320778
126RPS6KA10.46548261
127STK380.46314553
128MAP2K10.46281237
129PDK10.45890500
130FES0.45143560
131PINK10.44925415
132PRKD10.44863799
133MAPK80.44774279
134IKBKB0.43276978
135RIPK40.43106748
136FGFR20.41809034
137PRKCQ0.41709250
138CAMK2B0.41692187
139IRAK30.41543773
140PTK60.41348877
141ATR0.40958487
142MINK10.40730104
143MAPK120.40358240
144PRKCH0.39824232
145CSNK1A1L0.39409220
146ITK0.39153088
147BMX0.37625780
148MAP2K30.37573975
149LYN0.36054255
150AKT10.34697360
151STK30.34219908
152PRKCG0.33662110
153CAMK2A0.33187427
154TAOK30.33163321
155STK110.33042186
156PRKAA10.32730412

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.72172331
2Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91615648
3Phototransduction_Homo sapiens_hsa047441.89360871
4Morphine addiction_Homo sapiens_hsa050321.88679285
5Taste transduction_Homo sapiens_hsa047421.78994824
6Fanconi anemia pathway_Homo sapiens_hsa034601.69183980
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58653804
8Calcium signaling pathway_Homo sapiens_hsa040201.52907680
9Glutamatergic synapse_Homo sapiens_hsa047241.49821487
10Circadian entrainment_Homo sapiens_hsa047131.47707785
11Axon guidance_Homo sapiens_hsa043601.46605132
12Olfactory transduction_Homo sapiens_hsa047401.45329822
13Serotonergic synapse_Homo sapiens_hsa047261.36914476
14GnRH signaling pathway_Homo sapiens_hsa049121.36135244
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.35369073
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35168278
17Glioma_Homo sapiens_hsa052141.34637487
18Estrogen signaling pathway_Homo sapiens_hsa049151.33938502
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32797355
20Basal cell carcinoma_Homo sapiens_hsa052171.31648404
21Endometrial cancer_Homo sapiens_hsa052131.30615257
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26229897
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25345018
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25204206
25Type II diabetes mellitus_Homo sapiens_hsa049301.24334101
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21812228
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21808116
28Chronic myeloid leukemia_Homo sapiens_hsa052201.19273087
29Focal adhesion_Homo sapiens_hsa045101.17677715
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16133690
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14897975
32Ovarian steroidogenesis_Homo sapiens_hsa049131.13087032
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.12917759
34cAMP signaling pathway_Homo sapiens_hsa040241.12395096
35Hematopoietic cell lineage_Homo sapiens_hsa046401.11595711
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10504291
37Renin secretion_Homo sapiens_hsa049241.09755428
38Dilated cardiomyopathy_Homo sapiens_hsa054141.09624727
39GABAergic synapse_Homo sapiens_hsa047271.08703179
40Wnt signaling pathway_Homo sapiens_hsa043101.08247217
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08059247
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07829342
43Renal cell carcinoma_Homo sapiens_hsa052111.07798359
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07463482
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07321397
46Non-small cell lung cancer_Homo sapiens_hsa052231.06925951
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.06587188
48Cholinergic synapse_Homo sapiens_hsa047251.05312979
49Insulin secretion_Homo sapiens_hsa049111.04767274
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01552990
51Gap junction_Homo sapiens_hsa045400.99858962
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99414348
53Primary immunodeficiency_Homo sapiens_hsa053400.98495543
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97773731
55Amphetamine addiction_Homo sapiens_hsa050310.96932861
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96529635
57Hedgehog signaling pathway_Homo sapiens_hsa043400.96150913
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95397419
59Acute myeloid leukemia_Homo sapiens_hsa052210.95344157
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92812723
61Lysine degradation_Homo sapiens_hsa003100.91775672
62ErbB signaling pathway_Homo sapiens_hsa040120.91676627
63Prostate cancer_Homo sapiens_hsa052150.91595766
64Adherens junction_Homo sapiens_hsa045200.91585501
65Salivary secretion_Homo sapiens_hsa049700.91473394
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91078580
67ECM-receptor interaction_Homo sapiens_hsa045120.91065588
68VEGF signaling pathway_Homo sapiens_hsa043700.90736941
69Cocaine addiction_Homo sapiens_hsa050300.90724233
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90274124
71Measles_Homo sapiens_hsa051620.90142866
72mTOR signaling pathway_Homo sapiens_hsa041500.87794119
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87063677
74Autoimmune thyroid disease_Homo sapiens_hsa053200.86646511
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86269811
76Notch signaling pathway_Homo sapiens_hsa043300.85580490
77B cell receptor signaling pathway_Homo sapiens_hsa046620.84854806
78Melanoma_Homo sapiens_hsa052180.84475551
79Long-term depression_Homo sapiens_hsa047300.84056743
80Tight junction_Homo sapiens_hsa045300.83778260
81Oxytocin signaling pathway_Homo sapiens_hsa049210.83547580
82Thyroid hormone synthesis_Homo sapiens_hsa049180.82996120
83Ras signaling pathway_Homo sapiens_hsa040140.82664739
84Insulin signaling pathway_Homo sapiens_hsa049100.81042293
85Platelet activation_Homo sapiens_hsa046110.79095353
86MAPK signaling pathway_Homo sapiens_hsa040100.78948581
87Chemokine signaling pathway_Homo sapiens_hsa040620.77591598
88Dopaminergic synapse_Homo sapiens_hsa047280.77340605
89Prolactin signaling pathway_Homo sapiens_hsa049170.76504242
90Amoebiasis_Homo sapiens_hsa051460.76092925
91Osteoclast differentiation_Homo sapiens_hsa043800.75555241
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75181081
93Glucagon signaling pathway_Homo sapiens_hsa049220.74518862
94Sphingolipid metabolism_Homo sapiens_hsa006000.74341476
95TNF signaling pathway_Homo sapiens_hsa046680.74078048
96Pancreatic secretion_Homo sapiens_hsa049720.73623792
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73125425
98FoxO signaling pathway_Homo sapiens_hsa040680.73055076
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72496827
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72221365
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71767327
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.71743268
103Hippo signaling pathway_Homo sapiens_hsa043900.71028382
104African trypanosomiasis_Homo sapiens_hsa051430.70824190
105Colorectal cancer_Homo sapiens_hsa052100.69807443
106Protein digestion and absorption_Homo sapiens_hsa049740.69520903
107Circadian rhythm_Homo sapiens_hsa047100.69488954
108T cell receptor signaling pathway_Homo sapiens_hsa046600.69201071
109Long-term potentiation_Homo sapiens_hsa047200.69053391
110Melanogenesis_Homo sapiens_hsa049160.69023898
111Rap1 signaling pathway_Homo sapiens_hsa040150.68990859
112Inositol phosphate metabolism_Homo sapiens_hsa005620.68626172
113Gastric acid secretion_Homo sapiens_hsa049710.68287017
114Proteoglycans in cancer_Homo sapiens_hsa052050.68243386
115Allograft rejection_Homo sapiens_hsa053300.67191016
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.67181989
117Histidine metabolism_Homo sapiens_hsa003400.66983107
118Graft-versus-host disease_Homo sapiens_hsa053320.66007149
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65990403
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65636434
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64317313
122Insulin resistance_Homo sapiens_hsa049310.63914850
123Pathways in cancer_Homo sapiens_hsa052000.63233434
124MicroRNAs in cancer_Homo sapiens_hsa052060.63180159
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62019375
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61667969
127Thyroid cancer_Homo sapiens_hsa052160.60815480
128Choline metabolism in cancer_Homo sapiens_hsa052310.60654681
129Prion diseases_Homo sapiens_hsa050200.60600872
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59894092
131Small cell lung cancer_Homo sapiens_hsa052220.59460109
132Asthma_Homo sapiens_hsa053100.59438258
133Pancreatic cancer_Homo sapiens_hsa052120.58804477
134Non-homologous end-joining_Homo sapiens_hsa034500.58115089
135Homologous recombination_Homo sapiens_hsa034400.57650624
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.57619473
137Synaptic vesicle cycle_Homo sapiens_hsa047210.57342649
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57065328
139ABC transporters_Homo sapiens_hsa020100.56555816
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56129413
141Rheumatoid arthritis_Homo sapiens_hsa053230.55982093
142AMPK signaling pathway_Homo sapiens_hsa041520.55863447
143Dorso-ventral axis formation_Homo sapiens_hsa043200.55511891
144Mineral absorption_Homo sapiens_hsa049780.54916945

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