PRDM12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception (GO:0050961)9.12870850
2detection of temperature stimulus involved in sensory perception of pain (GO:0050965)9.12870850
3detection of temperature stimulus (GO:0016048)8.86902560
4substrate-independent telencephalic tangential interneuron migration (GO:0021843)8.17240593
5substrate-independent telencephalic tangential migration (GO:0021826)8.17240593
6neurofilament cytoskeleton organization (GO:0060052)6.82424548
7negative regulation of dendrite morphogenesis (GO:0050774)6.80029023
8neuronal action potential (GO:0019228)6.60247969
9urinary tract smooth muscle contraction (GO:0014848)6.52296194
10regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)6.47489492
11peripheral nervous system neuron development (GO:0048935)6.20325509
12behavioral response to pain (GO:0048266)6.01802713
13membrane repolarization during action potential (GO:0086011)5.96061390
14central nervous system myelination (GO:0022010)5.84991641
15axon ensheathment in central nervous system (GO:0032291)5.84991641
16negative regulation of calcium ion transport into cytosol (GO:0010523)5.64072034
17response to pain (GO:0048265)5.61605525
18presynaptic membrane organization (GO:0097090)5.38222812
19muscle cell fate commitment (GO:0042693)5.23047166
20membrane depolarization during action potential (GO:0086010)4.98122184
21tongue development (GO:0043586)4.97420600
22ovulation cycle (GO:0042698)4.89250134
23negative regulation of dendrite development (GO:2000171)4.77418025
24bundle of His cell to Purkinje myocyte communication (GO:0086069)4.74317272
25cell migration in hindbrain (GO:0021535)4.71144868
26cellular response to nicotine (GO:0071316)4.55951604
27neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.53259339
28negative regulation of homotypic cell-cell adhesion (GO:0034111)4.52009930
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.49857034
30myotube differentiation (GO:0014902)4.42869736
31detection of mechanical stimulus involved in sensory perception (GO:0050974)4.40447589
32regulation of bile acid biosynthetic process (GO:0070857)4.39828396
33axonal fasciculation (GO:0007413)4.37699732
34skeletal muscle fiber development (GO:0048741)4.37635043
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.31811297
36proline transport (GO:0015824)4.23693550
37regulation of platelet aggregation (GO:0090330)4.07196410
38daunorubicin metabolic process (GO:0044597)4.06466600
39polyketide metabolic process (GO:0030638)4.06466600
40doxorubicin metabolic process (GO:0044598)4.06466600
41positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.02457517
42retinal ganglion cell axon guidance (GO:0031290)4.01247496
43positive regulation of synaptic transmission, GABAergic (GO:0032230)4.01131287
44regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.97392131
45ribosomal small subunit assembly (GO:0000028)3.96961802
46peristalsis (GO:0030432)3.79750640
47neuron recognition (GO:0008038)3.76819471
48action potential (GO:0001508)3.76607910
49nucleobase catabolic process (GO:0046113)3.76104409
50neuronal action potential propagation (GO:0019227)3.73669291
51neuromuscular synaptic transmission (GO:0007274)3.71950358
52regulation of synapse structural plasticity (GO:0051823)3.71779947
53enteric nervous system development (GO:0048484)3.69624076
54response to water (GO:0009415)3.69439836
55response to inactivity (GO:0014854)3.66766148
56myotube cell development (GO:0014904)3.65196700
57positive regulation of growth hormone secretion (GO:0060124)3.63534416
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.63250984
59regulation of synaptic vesicle exocytosis (GO:2000300)3.62829858
60regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.60647762
61nerve growth factor signaling pathway (GO:0038180)3.57978303
62neuron cell-cell adhesion (GO:0007158)3.57873363
63adenosine metabolic process (GO:0046085)3.54190276
64cell communication involved in cardiac conduction (GO:0086065)3.50959210
65purinergic nucleotide receptor signaling pathway (GO:0035590)3.50024040
66glutathione biosynthetic process (GO:0006750)3.46142319
67potassium ion export (GO:0071435)3.40847822
68regulation of membrane repolarization (GO:0060306)3.40798909
69regulation of growth hormone secretion (GO:0060123)3.40085001
70response to ATP (GO:0033198)3.39632748
71innervation (GO:0060384)3.37326652
72regulation of transmission of nerve impulse (GO:0051969)3.36481426
73establishment of mitochondrion localization (GO:0051654)3.34495070
74sensory perception of pain (GO:0019233)3.28361424
75spinal cord association neuron differentiation (GO:0021527)3.28157618
76neuron fate specification (GO:0048665)3.27454743
77cellular response to estradiol stimulus (GO:0071392)3.26627789
78acrosome reaction (GO:0007340)3.24062979
79nonribosomal peptide biosynthetic process (GO:0019184)3.23660293
80multicellular organismal response to stress (GO:0033555)3.21138055
81G-protein coupled receptor internalization (GO:0002031)3.20616689
82axon cargo transport (GO:0008088)3.20442023
83glycine transport (GO:0015816)3.18295383
84glucocorticoid biosynthetic process (GO:0006704)3.17686257
85negative regulation of heart rate (GO:0010459)3.15319717
86regulation of synaptic vesicle transport (GO:1902803)3.14990728
87body morphogenesis (GO:0010171)3.13929371
88sensory perception of taste (GO:0050909)3.09346582
89positive regulation of cell size (GO:0045793)3.08610280
90ribosomal small subunit biogenesis (GO:0042274)3.06994036
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06152826
92mitochondrion transport along microtubule (GO:0047497)3.06152826
93negative regulation of microtubule polymerization (GO:0031115)3.05477074
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04606259
95regulation of astrocyte differentiation (GO:0048710)3.02878819
96regulation of homotypic cell-cell adhesion (GO:0034110)3.02651364
97auditory behavior (GO:0031223)2.98795402
98positive regulation of myotube differentiation (GO:0010831)2.98747839
99adult walking behavior (GO:0007628)2.97170467
100positive regulation of cardiac muscle hypertrophy (GO:0010613)2.95359780
101positive regulation of muscle hypertrophy (GO:0014742)2.95359780
102intermediate filament-based process (GO:0045103)2.94522031
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94515945
104intermediate filament organization (GO:0045109)2.92947444
105membrane budding (GO:0006900)2.90566450
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89592427
107intermediate filament cytoskeleton organization (GO:0045104)2.89352707
108behavioral response to nicotine (GO:0035095)2.88938652
109regulation of amyloid precursor protein catabolic process (GO:1902991)2.88123402
110establishment of monopolar cell polarity (GO:0061162)2.87064547
111establishment or maintenance of monopolar cell polarity (GO:0061339)2.87064547
112calcium ion-dependent exocytosis (GO:0017156)2.87055221
113sympathetic nervous system development (GO:0048485)2.86706395
114regulation of cell communication by electrical coupling (GO:0010649)2.86298392
115negative regulation of macroautophagy (GO:0016242)2.80356745
116ventricular cardiac muscle cell action potential (GO:0086005)2.79775044
117sodium ion transmembrane transport (GO:0035725)2.78996687
118regulation of potassium ion transmembrane transporter activity (GO:1901016)2.78955138
119maturation of 5.8S rRNA (GO:0000460)2.78601378
120neuronal ion channel clustering (GO:0045161)2.77210816
121positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.77191238
122positive regulation of cell cycle G2/M phase transition (GO:1902751)2.77191238
123glutamate secretion (GO:0014047)2.76883721
124viral transcription (GO:0019083)2.76033527
125cellular response to prostaglandin stimulus (GO:0071379)2.75595837
126cranial nerve development (GO:0021545)2.75029177
127response to pheromone (GO:0019236)2.74502655
128protein polyglutamylation (GO:0018095)2.74354661
129striated muscle atrophy (GO:0014891)2.73333164
130transcription from mitochondrial promoter (GO:0006390)2.72740788
131detection of mechanical stimulus (GO:0050982)2.70891094
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70476136
133regulation of sensory perception of pain (GO:0051930)2.68807504
134regulation of sensory perception (GO:0051931)2.68807504
135lens morphogenesis in camera-type eye (GO:0002089)2.67898541
136skeletal muscle organ development (GO:0060538)2.67017625
137epithelial cilium movement (GO:0003351)2.66288999
138organelle transport along microtubule (GO:0072384)2.64846894
139sequestering of actin monomers (GO:0042989)2.64232984
140transmission of nerve impulse (GO:0019226)2.64048204
141spinal cord development (GO:0021510)2.63591283
142negative regulation of catenin import into nucleus (GO:0035414)2.63390531
143regulation of feeding behavior (GO:0060259)2.62707514
144membrane repolarization (GO:0086009)2.62207913
145negative regulation of neurological system process (GO:0031645)2.61412007
146mating behavior (GO:0007617)2.61060307
147regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60964340
148neuron migration (GO:0001764)2.60578769
149synaptic vesicle maturation (GO:0016188)2.60041607
150pyrimidine nucleobase catabolic process (GO:0006208)2.59768870
151negative regulation of multicellular organism growth (GO:0040015)2.59132909
152activation of adenylate cyclase activity (GO:0007190)2.59084515
153cellular response to ATP (GO:0071318)2.58970981
154potassium ion import (GO:0010107)2.58817636
155translational termination (GO:0006415)2.57789920
156mechanoreceptor differentiation (GO:0042490)2.57781287
157membrane depolarization (GO:0051899)2.56574310
158positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.56226559
159regulation of synaptic transmission, GABAergic (GO:0032228)2.55954064
160purinergic receptor signaling pathway (GO:0035587)2.55173274
161calcium-mediated signaling using intracellular calcium source (GO:0035584)2.54649667
162response to parathyroid hormone (GO:0071107)2.54468141
163phasic smooth muscle contraction (GO:0014821)2.54198249
164regulation of female gonad development (GO:2000194)2.54047091
165axon development (GO:0061564)2.53914746
166muscle atrophy (GO:0014889)2.53750982
167protein localization to synapse (GO:0035418)2.53266740
168regulation of heart rate by cardiac conduction (GO:0086091)2.52451684
169response to acidic pH (GO:0010447)2.52151336
170positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.52103412
171coenzyme A biosynthetic process (GO:0015937)2.52059555
172ncRNA 3-end processing (GO:0043628)2.51091509
173central nervous system projection neuron axonogenesis (GO:0021952)2.50319379
174leukotriene biosynthetic process (GO:0019370)2.49697256
175estrogen biosynthetic process (GO:0006703)2.49522301
176thalamus development (GO:0021794)2.49444070
177replication fork processing (GO:0031297)2.46931261
178regulation of telomere maintenance via telomerase (GO:0032210)2.44034449
179maturation of SSU-rRNA (GO:0030490)2.43659703
180negative regulation of neurotransmitter secretion (GO:0046929)2.41852382
181vitamin catabolic process (GO:0009111)2.40680701
182fat-soluble vitamin catabolic process (GO:0042363)2.40680701
183embryonic body morphogenesis (GO:0010172)2.39483237
184negative regulation of telomere maintenance (GO:0032205)2.39158062
185negative regulation of cell cycle arrest (GO:0071157)2.38685443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78111686
2GBX2_23144817_ChIP-Seq_PC3_Human3.73224544
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.59392476
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95610592
5* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71851590
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70805970
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64365143
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.61791668
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60939216
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60939216
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60520472
12* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.58677525
13TAF15_26573619_Chip-Seq_HEK293_Human2.55663273
14* ERG_21242973_ChIP-ChIP_JURKAT_Human2.52928916
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42763336
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41922341
17VDR_22108803_ChIP-Seq_LS180_Human2.37525371
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.35801896
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29666287
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21030473
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.15962337
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13192051
23IGF1R_20145208_ChIP-Seq_DFB_Human2.03902602
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00970592
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98754744
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98135646
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87701103
28* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86990977
29SMAD4_21799915_ChIP-Seq_A2780_Human1.86223242
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83327608
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.83295607
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79724991
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76552224
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76540781
35P300_19829295_ChIP-Seq_ESCs_Human1.73457921
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.72199031
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70873889
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.70018340
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.68134523
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66385292
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65347908
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64743817
43MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.64427507
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.63407485
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61592860
46RNF2_27304074_Chip-Seq_NSC_Mouse1.61472430
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.59989463
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.59290769
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58914403
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58415415
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.58169372
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54219869
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53545615
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50617138
55* CBX2_27304074_Chip-Seq_ESCs_Mouse1.45386332
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45076092
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44658257
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41860048
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41386246
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40043789
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38980950
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38233239
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37624770
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37508900
65AHR_22903824_ChIP-Seq_MCF-7_Human1.36208377
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35888756
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.34142810
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33048730
69TTF2_22483619_ChIP-Seq_HELA_Human1.32666926
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31747918
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30454035
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30296289
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.29307363
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29229925
75DROSHA_22980978_ChIP-Seq_HELA_Human1.29068956
76AR_21572438_ChIP-Seq_LNCaP_Human1.29052760
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28812725
78STAT3_23295773_ChIP-Seq_U87_Human1.26339842
79XRN2_22483619_ChIP-Seq_HELA_Human1.25474343
80JUN_21703547_ChIP-Seq_K562_Human1.24389669
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24311262
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23540635
83KDM5A_27292631_Chip-Seq_BREAST_Human1.23399825
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.22379466
85AR_25329375_ChIP-Seq_VCAP_Human1.21747178
86P68_20966046_ChIP-Seq_HELA_Human1.20841377
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.20587996
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20554738
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20526649
90KDM2B_26808549_Chip-Seq_REH_Human1.20142481
91* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19341789
92* KDM2B_26808549_Chip-Seq_K562_Human1.19103096
93VDR_21846776_ChIP-Seq_THP-1_Human1.18873963
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17782987
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16718310
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16452984
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16427757
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15333719
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.14862200
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.14443900
101* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12674868
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12519472
103* GABP_19822575_ChIP-Seq_HepG2_Human1.12442789
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11535807
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.10412424
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10027390
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10015597
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09968358
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09223969
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.08683470
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08576259
112* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08525417
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.08462154
114* SMAD3_21741376_ChIP-Seq_ESCs_Human1.08028576
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07911836
116CTCF_27219007_Chip-Seq_Bcells_Human1.07788950
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.07649509
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.06732658
119EGR1_19032775_ChIP-ChIP_M12_Human1.05764650
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.03502608
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03318873
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.03286706
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.02840645
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.02349505
125RUNX2_22187159_ChIP-Seq_PCA_Human1.02281904
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01453117
127* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00555741
128PHF8_20622854_ChIP-Seq_HELA_Human1.00334630
129TCF4_23295773_ChIP-Seq_U87_Human1.00257651
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99089218
131E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98068545
132MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97982192
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.97711406
134IRF1_19129219_ChIP-ChIP_H3396_Human0.97397671
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.97146903
136P53_22387025_ChIP-Seq_ESCs_Mouse0.96968061
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.96795630
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96432150
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.96082249
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95682874
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95441665
142* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94956433
143* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94691358
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94379263
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94302239
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94302239
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94008232
148BCAT_22108803_ChIP-Seq_LS180_Human0.93858677
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.93773460
150* AR_19668381_ChIP-Seq_PC3_Human0.93037076
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92702423
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92208937
153LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91575038
154* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91396772
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91321788
156ZNF274_21170338_ChIP-Seq_K562_Hela0.90724676
157* NANOG_19829295_ChIP-Seq_ESCs_Human0.90652163
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90149255
159SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89607021
160* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88358222
161MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87286284
162MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86783254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception8.22134875
2MP0001968_abnormal_touch/_nociception6.71612166
3MP0002736_abnormal_nociception_after5.86159534
4MP0002822_catalepsy5.30549713
5MP0006276_abnormal_autonomic_nervous4.92747275
6MP0001986_abnormal_taste_sensitivity4.75055962
7MP0002733_abnormal_thermal_nociception4.23193740
8MP0004270_analgesia3.98645439
9MP0004858_abnormal_nervous_system3.79221067
10MP0002734_abnormal_mechanical_nocicepti3.63516524
11MP0001970_abnormal_pain_threshold3.58208446
12MP0003123_paternal_imprinting3.13046803
13MP0003315_abnormal_perineum_morphology3.07010903
14MP0008877_abnormal_DNA_methylation2.83589227
15MP0003787_abnormal_imprinting2.61374942
16MP0006292_abnormal_olfactory_placode2.55726620
17MP0000372_irregular_coat_pigmentation2.38340723
18MP0002751_abnormal_autonomic_nervous2.37891629
19MP0004859_abnormal_synaptic_plasticity2.28015932
20MP0002184_abnormal_innervation2.22252706
21MP0005423_abnormal_somatic_nervous2.15414381
22MP0005187_abnormal_penis_morphology2.14278278
23MP0002653_abnormal_ependyma_morphology2.07520741
24MP0002272_abnormal_nervous_system2.02855040
25MP0008995_early_reproductive_senescence2.00963389
26MP0002067_abnormal_sensory_capabilities2.00560380
27MP0003880_abnormal_central_pattern1.97183816
28MP0003121_genomic_imprinting1.94590425
29MP0005645_abnormal_hypothalamus_physiol1.80800232
30MP0003011_delayed_dark_adaptation1.80695791
31MP0001188_hyperpigmentation1.78948774
32MP0001529_abnormal_vocalization1.72071909
33MP0003938_abnormal_ear_development1.69588908
34MP0000631_abnormal_neuroendocrine_gland1.65497918
35MP0003942_abnormal_urinary_system1.58840788
36MP0001270_distended_abdomen1.57546597
37MP0000049_abnormal_middle_ear1.57443633
38MP0003635_abnormal_synaptic_transmissio1.57186962
39MP0000955_abnormal_spinal_cord1.49375946
40MP0000750_abnormal_muscle_regeneration1.47519558
41MP0002249_abnormal_larynx_morphology1.46524602
42MP0004811_abnormal_neuron_physiology1.44709711
43MP0009745_abnormal_behavioral_response1.44554983
44MP0010386_abnormal_urinary_bladder1.43037859
45MP0003195_calcinosis1.35812771
46MP0009046_muscle_twitch1.32548711
47MP0000778_abnormal_nervous_system1.32259147
48MP0002063_abnormal_learning/memory/cond1.30063662
49MP0002572_abnormal_emotion/affect_behav1.29010681
50MP0001984_abnormal_olfaction1.26192666
51MP0003385_abnormal_body_wall1.24107957
52MP0003646_muscle_fatigue1.24083854
53MP0003693_abnormal_embryo_hatching1.16599521
54MP0001348_abnormal_lacrimal_gland1.16492890
55MP0004133_heterotaxia1.16275867
56MP0003718_maternal_effect1.15913372
57MP0009053_abnormal_anal_canal1.13954106
58MP0002064_seizures1.12132868
59MP0002557_abnormal_social/conspecific_i1.09649047
60MP0008260_abnormal_autophagy1.07252700
61MP0002882_abnormal_neuron_morphology1.07224869
62MP0003879_abnormal_hair_cell1.05616037
63MP0009697_abnormal_copulation1.05555520
64MP0000537_abnormal_urethra_morphology1.01806270
65MP0003861_abnormal_nervous_system1.01038177
66MP0005220_abnormal_exocrine_pancreas0.97771015
67MP0000538_abnormal_urinary_bladder0.96336768
68MP0002152_abnormal_brain_morphology0.94961426
69MP0001286_abnormal_eye_development0.92583997
70MP0000681_abnormal_thyroid_gland0.92432286
71MP0001486_abnormal_startle_reflex0.92012306
72MP0000015_abnormal_ear_pigmentation0.91930463
73MP0005646_abnormal_pituitary_gland0.91313243
74MP0002752_abnormal_somatic_nervous0.91070111
75MP0005195_abnormal_posterior_eye0.89960197
76MP0003119_abnormal_digestive_system0.88852369
77MP0008932_abnormal_embryonic_tissue0.88281065
78MP0003115_abnormal_respiratory_system0.87305625
79MP0003937_abnormal_limbs/digits/tail_de0.86713601
80MP0002233_abnormal_nose_morphology0.86327598
81MP0001440_abnormal_grooming_behavior0.86084500
82MP0000569_abnormal_digit_pigmentation0.85787847
83MP0005409_darkened_coat_color0.83778821
84MP0004147_increased_porphyrin_level0.83359813
85MP0000534_abnormal_ureter_morphology0.80749563
86MP0003755_abnormal_palate_morphology0.80152585
87MP0004742_abnormal_vestibular_system0.78440965
88MP0002938_white_spotting0.78410798
89MP0002638_abnormal_pupillary_reflex0.78017301
90MP0002066_abnormal_motor_capabilities/c0.77873826
91MP0006072_abnormal_retinal_apoptosis0.77849100
92MP0002697_abnormal_eye_size0.77423230
93MP0002081_perinatal_lethality0.77274995
94MP0003878_abnormal_ear_physiology0.76680923
95MP0005377_hearing/vestibular/ear_phenot0.76680923
96MP0002210_abnormal_sex_determination0.76397254
97MP0001501_abnormal_sleep_pattern0.75861034
98MP0002876_abnormal_thyroid_physiology0.75593699
99MP0003136_yellow_coat_color0.75491012
100MP0004134_abnormal_chest_morphology0.75197022
101MP0004145_abnormal_muscle_electrophysio0.74350882
102MP0008569_lethality_at_weaning0.73679177
103MP0002108_abnormal_muscle_morphology0.73150507
104MP0003959_abnormal_lean_body0.72953518
105MP0004142_abnormal_muscle_tone0.72821692
106MP0000733_abnormal_muscle_development0.72704812
107MP0001963_abnormal_hearing_physiology0.71839446
108MP0005386_behavior/neurological_phenoty0.71468889
109MP0004924_abnormal_behavior0.71468889
110MP0005171_absent_coat_pigmentation0.69370386
111MP0003656_abnormal_erythrocyte_physiolo0.68660666
112MP0009379_abnormal_foot_pigmentation0.68450927
113MP0001346_abnormal_lacrimal_gland0.67851940
114MP0008004_abnormal_stomach_pH0.67209171
115MP0010771_integument_phenotype0.67184820
116MP0002229_neurodegeneration0.66687388
117MP0002277_abnormal_respiratory_mucosa0.65221578
118MP0000749_muscle_degeneration0.65136925
119MP0010030_abnormal_orbit_morphology0.64986697
120MP0005551_abnormal_eye_electrophysiolog0.64962727
121MP0003183_abnormal_peptide_metabolism0.63636404
122MP0004510_myositis0.61567236
123MP0003634_abnormal_glial_cell0.59869368
124MP0001664_abnormal_digestion0.59678813
125MP0008874_decreased_physiological_sensi0.59532564
126MP0003633_abnormal_nervous_system0.57973098
127MP0003868_abnormal_feces_composition0.57856225
128MP0001485_abnormal_pinna_reflex0.56162613
129MP0000579_abnormal_nail_morphology0.55272549
130MP0004085_abnormal_heartbeat0.54235278
131MP0003122_maternal_imprinting0.53624217
132MP0008789_abnormal_olfactory_epithelium0.53526588
133MP0000026_abnormal_inner_ear0.50201911
134MP0001299_abnormal_eye_distance/0.47599757
135MP0003172_abnormal_lysosome_physiology0.47594490
136MP0003329_amyloid_beta_deposits0.46852905
137MP0005174_abnormal_tail_pigmentation0.45925231
138MP0000566_synostosis0.43918478
139MP0002069_abnormal_eating/drinking_beha0.43124954
140MP0003631_nervous_system_phenotype0.42754595
141MP0001542_abnormal_bone_strength0.41285370
142MP0001905_abnormal_dopamine_level0.41173264
143MP0000920_abnormal_myelination0.38768264
144MP0005499_abnormal_olfactory_system0.36589696
145MP0005394_taste/olfaction_phenotype0.36589696
146MP0001943_abnormal_respiration0.34760429
147MP0002163_abnormal_gland_morphology0.34523876
148MP0005083_abnormal_biliary_tract0.33934548
149MP0002160_abnormal_reproductive_system0.31921162

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)8.10937009
2Myokymia (HP:0002411)5.53760658
3Dysautonomia (HP:0002459)5.34048524
4Segmental peripheral demyelination/remyelination (HP:0003481)5.08038268
5Action tremor (HP:0002345)4.83423347
6Ventricular fibrillation (HP:0001663)4.81513392
7Impaired pain sensation (HP:0007328)4.78814001
8Abnormality of pain sensation (HP:0010832)4.78814001
9Pheochromocytoma (HP:0002666)4.68428158
10Arthropathy (HP:0003040)4.62868948
11Neuroendocrine neoplasm (HP:0100634)4.24814214
12Insidious onset (HP:0003587)4.18968064
13Termporal pattern (HP:0011008)4.18968064
14Hypothermia (HP:0002045)4.18633037
15Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.12543585
16Febrile seizures (HP:0002373)4.12370493
17Recurrent corneal erosions (HP:0000495)4.11936524
18Failure to thrive in infancy (HP:0001531)4.09636572
19Autoamputation (HP:0001218)4.08654407
20Oligodactyly (hands) (HP:0001180)4.01038585
21Thyroid carcinoma (HP:0002890)3.98182731
22Abnormality of dental color (HP:0011073)3.61139855
23Steppage gait (HP:0003376)3.57066274
24Submucous cleft hard palate (HP:0000176)3.18676269
25Hammertoe (HP:0001765)3.18529845
26Abnormal hair whorl (HP:0010721)3.15995660
27Oligodactyly (HP:0012165)3.14557503
28Abnormality of calcium-phosphate metabolism (HP:0100530)3.13523657
29Metaphyseal dysplasia (HP:0100255)3.13416512
30Foot dorsiflexor weakness (HP:0009027)3.13378575
31Neoplasm of the adrenal cortex (HP:0100641)3.07377008
32Atonic seizures (HP:0010819)3.02026309
33Abnormal autonomic nervous system physiology (HP:0012332)3.00628706
34Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.99108796
35Hypoplasia of the brainstem (HP:0002365)2.98735675
36Aplasia/Hypoplasia of the brainstem (HP:0007362)2.98735675
37Hypoventilation (HP:0002791)2.97834483
38Progressive cerebellar ataxia (HP:0002073)2.97125011
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.94588358
40Absent/shortened dynein arms (HP:0200106)2.94588358
41Hyperthyroidism (HP:0000836)2.92091510
42Pendular nystagmus (HP:0012043)2.91525311
43Self-mutilation (HP:0000742)2.89221779
44Anterior segment dysgenesis (HP:0007700)2.88911490
45Ankle clonus (HP:0011448)2.87741921
46Optic nerve coloboma (HP:0000588)2.86642112
47Hepatoblastoma (HP:0002884)2.85496270
48Focal seizures (HP:0007359)2.84368184
49Abnormality of the foot musculature (HP:0001436)2.78861488
50Pachygyria (HP:0001302)2.78589795
51Hypercortisolism (HP:0001578)2.76154737
52Acute necrotizing encephalopathy (HP:0006965)2.73604058
53Focal motor seizures (HP:0011153)2.73190229
54Macroorchidism (HP:0000053)2.72613223
55Prolonged QT interval (HP:0001657)2.72335108
56Abnormality of magnesium homeostasis (HP:0004921)2.71724130
57Hypomagnesemia (HP:0002917)2.70451552
58Bradycardia (HP:0001662)2.68610224
59Impaired proprioception (HP:0010831)2.68545368
60Onion bulb formation (HP:0003383)2.64097064
61Abnormality of the corticospinal tract (HP:0002492)2.58642529
62Decreased motor nerve conduction velocity (HP:0003431)2.55149972
63Myotonia (HP:0002486)2.55081995
64Distal arthrogryposis (HP:0005684)2.53612816
65Abnormal mitochondria in muscle tissue (HP:0008316)2.50884083
66Supranuclear gaze palsy (HP:0000605)2.50612459
67Episodic fever (HP:0001954)2.49483575
68Facial shape deformation (HP:0011334)2.47948118
69Potter facies (HP:0002009)2.47948118
70Anhidrosis (HP:0000970)2.47729448
71Chin dimple (HP:0010751)2.47626374
72Patellar aplasia (HP:0006443)2.46899273
73Limb dystonia (HP:0002451)2.44680314
74Pancreatic fibrosis (HP:0100732)2.43515380
75Abnormality of the 4th metacarpal (HP:0010012)2.42911292
76Diastasis recti (HP:0001540)2.42496787
77Abnormality of the vocal cords (HP:0008777)2.41976076
78Aplasia/Hypoplasia of the patella (HP:0006498)2.37195576
79Cutaneous finger syndactyly (HP:0010554)2.36478141
80Abnormality of the aortic arch (HP:0012303)2.35684937
81Visual hallucinations (HP:0002367)2.35449065
82Lissencephaly (HP:0001339)2.34781627
83Type 2 muscle fiber atrophy (HP:0003554)2.33417626
84High anterior hairline (HP:0009890)2.30656108
85Anophthalmia (HP:0000528)2.29950489
86Epileptic encephalopathy (HP:0200134)2.29830874
87Abnormal number of incisors (HP:0011064)2.29636172
88Enlarged kidneys (HP:0000105)2.29095412
89Syncope (HP:0001279)2.26943285
90Abnormality of cells of the erythroid lineage (HP:0012130)2.26600896
91Distal sensory impairment (HP:0002936)2.23667703
92Abnormality of B cell number (HP:0010975)2.20188141
93Neoplasm of the peripheral nervous system (HP:0100007)2.19924153
94Akinesia (HP:0002304)2.19349148
95Orthostatic hypotension (HP:0001278)2.18818138
96Adrenal hypoplasia (HP:0000835)2.17565161
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.16245963
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16150236
99Muscle fiber atrophy (HP:0100295)2.12740581
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11044051
101Short 4th metacarpal (HP:0010044)2.11044051
102Curly hair (HP:0002212)2.09782608
103Absent eyebrow (HP:0002223)2.09712951
104Overriding aorta (HP:0002623)2.07995492
105Spinal canal stenosis (HP:0003416)2.07157947
106Overlapping toe (HP:0001845)2.06827517
107Anosmia (HP:0000458)2.06552542
108Neoplasm of the thyroid gland (HP:0100031)2.06359126
109Acute encephalopathy (HP:0006846)2.05808480
110Abnormality of the nasal septum (HP:0000419)2.05785045
111Fetal akinesia sequence (HP:0001989)2.05648968
112Hyperacusis (HP:0010780)2.05344685
113Increased IgM level (HP:0003496)2.04765885
114Peripheral hypomyelination (HP:0007182)2.04403660
115Urinary urgency (HP:0000012)2.02927695
116Severe visual impairment (HP:0001141)2.02575349
117Down-sloping shoulders (HP:0200021)2.02229331
118Anencephaly (HP:0002323)2.01742885
119Esophageal atresia (HP:0002032)2.01553350
120Abnormality of homocysteine metabolism (HP:0010919)2.01141916
121Homocystinuria (HP:0002156)2.01141916
122Keratitis (HP:0000491)2.00670808
123Macrocytic anemia (HP:0001972)2.00520318
124Stenosis of the external auditory canal (HP:0000402)1.98735246
125Increased corneal curvature (HP:0100692)1.98489349
126Keratoconus (HP:0000563)1.98489349
127Neonatal hypoglycemia (HP:0001998)1.98463920
128Abnormality of macular pigmentation (HP:0008002)1.97937156
129Growth hormone deficiency (HP:0000824)1.96861331
130Mitochondrial inheritance (HP:0001427)1.96833573
131Abnormality of the parathyroid morphology (HP:0011766)1.94544723
132Progressive macrocephaly (HP:0004481)1.94118534
133Cutaneous syndactyly (HP:0012725)1.93490379
134Spastic gait (HP:0002064)1.93117849
135Urinary bladder sphincter dysfunction (HP:0002839)1.92665123
136Abnormal respiratory epithelium morphology (HP:0012253)1.91498130
137Abnormal respiratory motile cilium morphology (HP:0005938)1.91498130
138Sclerocornea (HP:0000647)1.91429357
139Popliteal pterygium (HP:0009756)1.90762484
140Abolished electroretinogram (ERG) (HP:0000550)1.90054632
141Mask-like facies (HP:0000298)1.87857332
142Renovascular hypertension (HP:0100817)1.86443473
143Rib fusion (HP:0000902)1.85228516
144Distal lower limb muscle weakness (HP:0009053)1.85113987
145Absent eyelashes (HP:0000561)1.84604787
146Elfin facies (HP:0004428)1.83851037
147Generalized tonic-clonic seizures (HP:0002069)1.82500143
148Retinal dysplasia (HP:0007973)1.82171882
149Morphological abnormality of the middle ear (HP:0008609)1.82157225
150Poor suck (HP:0002033)1.81600983
151Stomach cancer (HP:0012126)1.81346350
152Paraplegia (HP:0010550)1.79576183
153Horseshoe kidney (HP:0000085)1.79539884
154Areflexia of lower limbs (HP:0002522)1.79109608
155Lipid accumulation in hepatocytes (HP:0006561)1.78884580
156Aplasia of the musculature (HP:0100854)1.78581513
157Amblyopia (HP:0000646)1.77713362
158Upper limb muscle weakness (HP:0003484)1.77185130
159Increased CSF lactate (HP:0002490)1.76719426
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75667138
161Maternal diabetes (HP:0009800)1.75475014
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.75005959
163Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75005959
164Renal dysplasia (HP:0000110)1.74045329
165Lower limb muscle weakness (HP:0007340)1.73348870
166Impaired vibration sensation in the lower limbs (HP:0002166)1.71921872
167Supernumerary bones of the axial skeleton (HP:0009144)1.71828929
168Aqueductal stenosis (HP:0002410)1.71302603
169Abnormal eating behavior (HP:0100738)1.70674666
170Supernumerary ribs (HP:0005815)1.70302120
171Abnormality of the carotid arteries (HP:0005344)1.70116316
172Aplasia/Hypoplasia of the sternum (HP:0006714)1.70109510
173Exotropia (HP:0000577)1.69726530
174Hypogonadotrophic hypogonadism (HP:0000044)1.69419589
175Malignant hyperthermia (HP:0002047)1.68927160
176Spastic paraplegia (HP:0001258)1.68369364
177Postural tremor (HP:0002174)1.67704158
178Adrenal overactivity (HP:0002717)1.67093044
179Enlarged penis (HP:0000040)1.66776841
180Abnormal number of erythroid precursors (HP:0012131)1.66276103
181Synostosis of carpal bones (HP:0005048)1.64033060
182Decreased muscle mass (HP:0003199)1.64007465
183Heterochromia iridis (HP:0001100)1.63114700
184Torticollis (HP:0000473)1.62936971
185Large eyes (HP:0001090)1.61624971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MOS6.67173942
2NTRK15.52836769
3SIK34.30819773
4NTRK33.88750020
5MATK3.82797897
6CAMK1D3.65329677
7ICK3.42337505
8LMTK23.10477513
9CAMK1G2.77992669
10MINK12.77940176
11KSR22.71092861
12CASK2.71058324
13MARK32.53851239
14EPHA32.51105472
15MAP3K92.49681244
16WNK32.46804093
17LIMK12.38124237
18MAP3K22.22775020
19DYRK1B2.20199510
20GRK52.08998407
21DYRK32.06469911
22MAP3K121.99953467
23MAPK131.97114128
24ZAK1.93967371
25MAP3K111.93293049
26RIPK41.71271115
27ADRBK21.67365934
28SGK21.66180555
29BMPR1B1.65494012
30RET1.64409840
31CDK151.62866563
32CDK11A1.56340342
33CDK181.54958909
34SGK2231.54636205
35SGK4941.54636205
36LATS21.51522475
37CDK191.51327744
38ARAF1.43540462
39FER1.37783565
40PTK61.36424914
41MAP2K71.34386061
42PHKG21.33538149
43PHKG11.33538149
44TYRO31.31843915
45NTRK21.23426402
46MARK11.22690105
47SIK21.19050554
48RPS6KA21.12367215
49PRPF4B1.06643817
50YES11.05467420
51SGK31.05293478
52DYRK21.03965256
53CSNK1G31.02037024
54MAP2K11.01612582
55NME11.00332234
56PAK60.97427086
57ERBB20.96112589
58PRKCI0.94508612
59PRKG20.92240546
60CAMKK20.90706722
61PRKD20.90530185
62CDK70.90149769
63MAP3K60.88433440
64EPHA40.88272268
65BCR0.87508614
66PKN10.86950517
67WNK10.86428071
68BRAF0.85429844
69TNK20.82616323
70EPHB20.82057823
71DYRK1A0.79217942
72CAMK10.78023837
73MAP3K100.77467185
74MAPK150.76675795
75STK110.76340362
76CDK80.76313254
77MAP3K40.76199166
78PINK10.74044136
79BLK0.73882392
80CDK50.73635475
81PRKD30.72678535
82CSNK1E0.72507471
83ADRBK10.71392398
84TAOK10.71338695
85DAPK20.70720346
86MAP2K40.70130159
87UHMK10.70120209
88MAP3K10.68679834
89AKT30.68563466
90RPS6KB20.68269574
91PRKCE0.65898954
92MAP2K20.65767075
93MAP2K60.65643787
94AKT20.64552878
95PRKCG0.62503095
96KSR10.61528975
97ABL20.61084044
98BMPR20.60991186
99CSNK1A1L0.60664678
100ATR0.58898046
101MARK20.57592345
102AURKA0.57336871
103PNCK0.57233743
104CSNK1G10.57202171
105CDC42BPA0.56721450
106DDR20.54704918
107TLK10.54547712
108TESK10.54284869
109CAMKK10.53387747
110CSNK1D0.50863584
111CDK140.50321816
112PRKAA10.49875457
113FGFR30.47984783
114TNIK0.47808320
115NUAK10.47782736
116MTOR0.47306715
117CDK10.46922260
118MAP3K70.46658075
119TXK0.46076714
120CHEK20.45802177
121BCKDK0.44168352
122GRK10.43780685
123ERBB30.43438870
124SIK10.42269539
125MAPK100.41419860
126SRPK10.40827522
127CDK20.40318558
128AKT10.39740513
129PRKCZ0.39475584
130CAMK40.38987902
131STK160.36910107
132CAMK2A0.36522315
133MAPK80.35909231
134ROCK10.35122291
135MAP3K130.31419900
136PRKDC0.31099437
137GSK3B0.31077771
138PLK10.30542327
139HIPK20.30274707
140PRKCD0.29859460
141IRAK20.29701424
142IRAK10.29097981
143PRKACA0.28053539
144ROCK20.27942991
145SRC0.27033830
146RPS6KB10.26347592
147STK390.25663032
148PASK0.24937848
149LRRK20.24758683
150PLK20.24690338
151PRKD10.24589984
152CDK90.24584636
153SYK0.24279990
154CSNK1G20.22962299
155PTK2B0.22262833
156WNK40.20900254
157MAP3K140.18853446
158MUSK0.18808340
159JAK10.17698581
160PTK20.17331115
161PDK10.16980164
162PRKCA0.16904759
163PRKACB0.16890789
164TSSK60.16772888

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.55669181
2Selenocompound metabolism_Homo sapiens_hsa004503.48965214
3Synaptic vesicle cycle_Homo sapiens_hsa047213.42095316
4Ribosome_Homo sapiens_hsa030103.15434876
5Sulfur relay system_Homo sapiens_hsa041222.99999928
6Taste transduction_Homo sapiens_hsa047422.65716563
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.60678188
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.57455177
9Parkinsons disease_Homo sapiens_hsa050122.56932402
10Thyroid cancer_Homo sapiens_hsa052162.44729846
11Cocaine addiction_Homo sapiens_hsa050302.35651151
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.35390056
13One carbon pool by folate_Homo sapiens_hsa006702.27731960
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.12188594
15Basal cell carcinoma_Homo sapiens_hsa052172.07946491
16Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.03426713
17Olfactory transduction_Homo sapiens_hsa047402.01517006
18Nicotine addiction_Homo sapiens_hsa050332.00144510
19Insulin secretion_Homo sapiens_hsa049111.81232702
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72442907
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71769755
22Hedgehog signaling pathway_Homo sapiens_hsa043401.71114217
23Collecting duct acid secretion_Homo sapiens_hsa049661.66237780
24Serotonergic synapse_Homo sapiens_hsa047261.63465276
25Cholinergic synapse_Homo sapiens_hsa047251.62735807
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.59986455
27Dopaminergic synapse_Homo sapiens_hsa047281.56594726
28Huntingtons disease_Homo sapiens_hsa050161.56453814
29Axon guidance_Homo sapiens_hsa043601.56028131
30Circadian entrainment_Homo sapiens_hsa047131.55706508
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55267499
32Morphine addiction_Homo sapiens_hsa050321.47551641
33Glutamatergic synapse_Homo sapiens_hsa047241.47069331
34Alcoholism_Homo sapiens_hsa050341.46856664
35Long-term potentiation_Homo sapiens_hsa047201.43376798
36Base excision repair_Homo sapiens_hsa034101.42645334
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41388102
38Vibrio cholerae infection_Homo sapiens_hsa051101.40259954
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36762265
40Melanoma_Homo sapiens_hsa052181.32765456
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32498688
42RNA polymerase_Homo sapiens_hsa030201.31833798
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28100374
44GABAergic synapse_Homo sapiens_hsa047271.26421287
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23428528
46Endometrial cancer_Homo sapiens_hsa052131.23186530
47Prolactin signaling pathway_Homo sapiens_hsa049171.20915294
48Phagosome_Homo sapiens_hsa041451.20513761
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20156194
50Long-term depression_Homo sapiens_hsa047301.19334416
51ErbB signaling pathway_Homo sapiens_hsa040121.18273502
52RNA transport_Homo sapiens_hsa030131.17023630
53Salmonella infection_Homo sapiens_hsa051321.16034335
54Fatty acid biosynthesis_Homo sapiens_hsa000611.14449159
55Dorso-ventral axis formation_Homo sapiens_hsa043201.14080207
56RNA degradation_Homo sapiens_hsa030181.14000881
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12874889
58Glioma_Homo sapiens_hsa052141.12396926
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12066035
60Type II diabetes mellitus_Homo sapiens_hsa049301.11230986
61Calcium signaling pathway_Homo sapiens_hsa040201.11107964
62Pyrimidine metabolism_Homo sapiens_hsa002401.10903751
63Salivary secretion_Homo sapiens_hsa049701.10693778
64Cell cycle_Homo sapiens_hsa041101.09427789
65DNA replication_Homo sapiens_hsa030301.08109363
66Central carbon metabolism in cancer_Homo sapiens_hsa052301.07332283
67Regulation of autophagy_Homo sapiens_hsa041401.05610188
68Steroid biosynthesis_Homo sapiens_hsa001001.01666180
69Fanconi anemia pathway_Homo sapiens_hsa034600.99139993
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98098939
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92452609
72Melanogenesis_Homo sapiens_hsa049160.92405532
73GnRH signaling pathway_Homo sapiens_hsa049120.92299894
74Butanoate metabolism_Homo sapiens_hsa006500.90408750
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89660605
76Linoleic acid metabolism_Homo sapiens_hsa005910.88299132
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87825092
78Spliceosome_Homo sapiens_hsa030400.87791329
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87474833
80mRNA surveillance pathway_Homo sapiens_hsa030150.87099029
81Hippo signaling pathway_Homo sapiens_hsa043900.85983306
82Rheumatoid arthritis_Homo sapiens_hsa053230.84448275
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82683316
84Gap junction_Homo sapiens_hsa045400.81442286
85Gastric acid secretion_Homo sapiens_hsa049710.80743382
86VEGF signaling pathway_Homo sapiens_hsa043700.78621286
87Cardiac muscle contraction_Homo sapiens_hsa042600.77662181
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.75493206
89Fatty acid elongation_Homo sapiens_hsa000620.75037806
90Insulin signaling pathway_Homo sapiens_hsa049100.74960081
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73519417
92Estrogen signaling pathway_Homo sapiens_hsa049150.72914008
93Non-homologous end-joining_Homo sapiens_hsa034500.70732799
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70440451
95MAPK signaling pathway_Homo sapiens_hsa040100.69991835
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.68488999
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66732017
98Ras signaling pathway_Homo sapiens_hsa040140.65965306
99Choline metabolism in cancer_Homo sapiens_hsa052310.64248379
100Oxytocin signaling pathway_Homo sapiens_hsa049210.63428627
101Endocytosis_Homo sapiens_hsa041440.61633426
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.59869107
103Vitamin B6 metabolism_Homo sapiens_hsa007500.59570513
104Purine metabolism_Homo sapiens_hsa002300.59239757
105Ovarian steroidogenesis_Homo sapiens_hsa049130.58958947
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58836025
107Amphetamine addiction_Homo sapiens_hsa050310.58209377
108Ether lipid metabolism_Homo sapiens_hsa005650.57699138
109Mineral absorption_Homo sapiens_hsa049780.57320545
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56872753
111Rap1 signaling pathway_Homo sapiens_hsa040150.56459819
112Oocyte meiosis_Homo sapiens_hsa041140.55620304
113Fatty acid metabolism_Homo sapiens_hsa012120.54453949
114Renin secretion_Homo sapiens_hsa049240.51094698
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51012373
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.50609999
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50345298
118Nucleotide excision repair_Homo sapiens_hsa034200.49985559
119Notch signaling pathway_Homo sapiens_hsa043300.49333537
120p53 signaling pathway_Homo sapiens_hsa041150.48907791
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48070198
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48068497
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47888989
124Shigellosis_Homo sapiens_hsa051310.46732069
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46004208
126cAMP signaling pathway_Homo sapiens_hsa040240.45691926
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45416665
128Chemokine signaling pathway_Homo sapiens_hsa040620.44940607
129Tuberculosis_Homo sapiens_hsa051520.44326355
130Homologous recombination_Homo sapiens_hsa034400.43541863
131Pentose phosphate pathway_Homo sapiens_hsa000300.43488885
132Pertussis_Homo sapiens_hsa051330.43297210
133Phototransduction_Homo sapiens_hsa047440.43264688
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43168476
135Colorectal cancer_Homo sapiens_hsa052100.41862013
136Oxidative phosphorylation_Homo sapiens_hsa001900.41406663
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41137892
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.41084725
139African trypanosomiasis_Homo sapiens_hsa051430.41001852
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40495200
141Pancreatic secretion_Homo sapiens_hsa049720.39899663
142Non-small cell lung cancer_Homo sapiens_hsa052230.39838058
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39331405
144Alzheimers disease_Homo sapiens_hsa050100.39269890
145Folate biosynthesis_Homo sapiens_hsa007900.39045862
146beta-Alanine metabolism_Homo sapiens_hsa004100.38926955
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37117019
148Retinol metabolism_Homo sapiens_hsa008300.36920923
149Caffeine metabolism_Homo sapiens_hsa002320.36493206
150Wnt signaling pathway_Homo sapiens_hsa043100.36319085
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36117465
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35655169
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35252376
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35126695
155Apoptosis_Homo sapiens_hsa042100.34948604
156Biosynthesis of amino acids_Homo sapiens_hsa012300.32716270
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.31978968
158Mismatch repair_Homo sapiens_hsa034300.31729835
159Glycerolipid metabolism_Homo sapiens_hsa005610.31368322
160Fat digestion and absorption_Homo sapiens_hsa049750.30097681
161Pathways in cancer_Homo sapiens_hsa052000.29560299
162Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28600900

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