PRDM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.74408047
2cytoplasmic mRNA processing body assembly (GO:0033962)4.46531471
3NLS-bearing protein import into nucleus (GO:0006607)4.41678468
4B cell receptor signaling pathway (GO:0050853)4.19947942
5positive regulation of histone deacetylation (GO:0031065)4.16024948
6negative regulation of cell killing (GO:0031342)4.02800378
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02800378
8pre-miRNA processing (GO:0031054)3.97795278
9nuclear pore complex assembly (GO:0051292)3.73366542
10histone H3-K4 methylation (GO:0051568)3.64901395
11regulation of NFAT protein import into nucleus (GO:0051532)3.55276309
12histone H3-K4 trimethylation (GO:0080182)3.53723241
13histone H3-K36 demethylation (GO:0070544)3.53572852
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47314887
15positive regulation of granulocyte differentiation (GO:0030854)3.34843683
16positive thymic T cell selection (GO:0045059)3.33736934
17glucocorticoid receptor signaling pathway (GO:0042921)3.31456817
18regulation of RNA export from nucleus (GO:0046831)3.27375533
19positive regulation of B cell differentiation (GO:0045579)3.25989916
20mitotic sister chromatid cohesion (GO:0007064)3.25491784
21thymic T cell selection (GO:0045061)3.24169577
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.23191016
23B cell homeostasis (GO:0001782)3.22517475
24regulation of germinal center formation (GO:0002634)3.19897834
25negative thymic T cell selection (GO:0045060)3.19100848
26germinal center formation (GO:0002467)3.16753680
27regulation of gamma-delta T cell differentiation (GO:0045586)3.15596860
28negative T cell selection (GO:0043383)3.13766628
29positive regulation of gamma-delta T cell activation (GO:0046645)3.12792922
30nuclear pore organization (GO:0006999)3.09752082
31macrophage activation involved in immune response (GO:0002281)3.02759250
32response to muramyl dipeptide (GO:0032495)3.02440713
33regulation of Rap GTPase activity (GO:0032317)3.01482304
34regulation of B cell differentiation (GO:0045577)3.00917388
35positive regulation of gene expression, epigenetic (GO:0045815)2.98344309
36modulation by symbiont of host immune response (GO:0052553)2.97232763
37positive regulation by symbiont of host defense response (GO:0052509)2.97232763
38modulation by symbiont of host defense response (GO:0052031)2.97232763
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97232763
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97232763
41positive regulation by organism of defense response of other organism involved in symbiotic interact2.97232763
42cellular extravasation (GO:0045123)2.96322782
43T cell selection (GO:0045058)2.94052734
44histone H3-K9 demethylation (GO:0033169)2.93989229
45histone lysine demethylation (GO:0070076)2.92106584
46cellular response to interleukin-15 (GO:0071350)2.89945205
47histone H4-K16 acetylation (GO:0043984)2.89183249
48positive regulation of protein deacetylation (GO:0090312)2.88502269
49corticosteroid receptor signaling pathway (GO:0031958)2.88244240
50CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.86231454
51regulation of gamma-delta T cell activation (GO:0046643)2.84350570
52positive T cell selection (GO:0043368)2.82917561
53mRNA stabilization (GO:0048255)2.82633128
54RNA stabilization (GO:0043489)2.82633128
55histone H3-K9 modification (GO:0061647)2.82012888
56trophectodermal cell differentiation (GO:0001829)2.81817402
57gene silencing by RNA (GO:0031047)2.81617843
58regulation of nucleobase-containing compound transport (GO:0032239)2.79542435
59negative regulation of T-helper cell differentiation (GO:0045623)2.79237704
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79237704
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79124259
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77315026
63pore complex assembly (GO:0046931)2.76596720
64regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.76373185
65histone demethylation (GO:0016577)2.74402096
66negative regulation of histone methylation (GO:0031061)2.72622445
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70986073
68intracellular estrogen receptor signaling pathway (GO:0030520)2.69926516
69negative regulation of T cell mediated immunity (GO:0002710)2.69009880
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.68687345
71heterochromatin organization (GO:0070828)2.66552701
72activated T cell proliferation (GO:0050798)2.64882489
73peptidyl-threonine phosphorylation (GO:0018107)2.64378720
74T cell migration (GO:0072678)2.64278309
75tolerance induction (GO:0002507)2.64211320
76regulation of histone deacetylation (GO:0031063)2.64148540
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63106963
78antigen receptor-mediated signaling pathway (GO:0050851)2.62621708
79regulation of protein polyubiquitination (GO:1902914)2.61069027
80interferon-gamma-mediated signaling pathway (GO:0060333)2.59039073
81* histone lysine methylation (GO:0034968)2.58681216
82peptidyl-threonine modification (GO:0018210)2.57550921
83cerebellar Purkinje cell differentiation (GO:0021702)2.56991132
84stress granule assembly (GO:0034063)2.56586341
85gene silencing (GO:0016458)2.56147929
86negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54794362
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.54794362
88regulation of translation, ncRNA-mediated (GO:0045974)2.54794362
89receptor catabolic process (GO:0032801)2.54769629
90histone H4-K5 acetylation (GO:0043981)2.54639686
91histone H4-K8 acetylation (GO:0043982)2.54639686
92regulation of alpha-beta T cell proliferation (GO:0046640)2.54178998
93negative regulation of lymphocyte mediated immunity (GO:0002707)2.53757204
94nerve growth factor signaling pathway (GO:0038180)2.53128862
95protein dealkylation (GO:0008214)2.52507143
96protein demethylation (GO:0006482)2.52507143
97histone H4-K12 acetylation (GO:0043983)2.51958500
98immunoglobulin mediated immune response (GO:0016064)2.50843922
99regulation of interferon-beta biosynthetic process (GO:0045357)2.50386973
100regulation of B cell proliferation (GO:0030888)2.49892304
101cellular response to ethanol (GO:0071361)2.49319285
102regulation of hippo signaling (GO:0035330)2.47949698
103regulation of granulocyte differentiation (GO:0030852)2.47498793
104microglial cell activation (GO:0001774)2.47410839
105peptidyl-lysine methylation (GO:0018022)2.47168744
106detection of other organism (GO:0098543)2.47006424
107defense response to protozoan (GO:0042832)2.46928366
108positive regulation of interleukin-2 production (GO:0032743)2.45019724
109regulation of integrin activation (GO:0033623)2.44933932
110peptidyl-lysine trimethylation (GO:0018023)2.44894586
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44772432
112JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44414252
113detection of bacterium (GO:0016045)2.44117960
114interkinetic nuclear migration (GO:0022027)2.44074940
115negative regulation of cAMP-mediated signaling (GO:0043951)2.43428573
116interferon-gamma production (GO:0032609)2.43420963
117regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.42694812
118retrograde transport, vesicle recycling within Golgi (GO:0000301)2.41662702
119negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.41654608
120embryonic process involved in female pregnancy (GO:0060136)2.40637884
121leukocyte aggregation (GO:0070486)2.39657818
122positive regulation of humoral immune response (GO:0002922)2.39001413
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.38947169
124negative regulation of B cell proliferation (GO:0030889)2.38147059
125negative regulation of adaptive immune response (GO:0002820)2.38143126
126growth hormone receptor signaling pathway (GO:0060396)2.38036625
127cortical actin cytoskeleton organization (GO:0030866)2.36270403
128negative regulation of granulocyte differentiation (GO:0030853)2.36133232
129antigen processing and presentation of endogenous antigen (GO:0019883)2.36070583
130protein targeting to Golgi (GO:0000042)2.36029560
131regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34600699
132negative regulation of erythrocyte differentiation (GO:0045647)2.34359200
133negative regulation of cell size (GO:0045792)2.33931314
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.33712312
135peptidyl-lysine dimethylation (GO:0018027)2.33692820
136protein localization to endosome (GO:0036010)2.33561584
137negative regulation of bone resorption (GO:0045779)2.33347482
138positive regulation of B cell proliferation (GO:0030890)2.32791677
139lymphocyte homeostasis (GO:0002260)2.32351396
140mast cell activation (GO:0045576)2.31952795
141regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.31669701
142negative regulation of fatty acid transport (GO:2000192)2.31330584
143mannose metabolic process (GO:0006013)2.31169403
144regulation of protein deacetylation (GO:0090311)2.31106903
145establishment of protein localization to Golgi (GO:0072600)2.30981298
146embryonic placenta development (GO:0001892)2.30159445
147dosage compensation (GO:0007549)2.29903045
148determination of adult lifespan (GO:0008340)2.29811122
149regulation of ARF protein signal transduction (GO:0032012)2.28075988
150monoubiquitinated protein deubiquitination (GO:0035520)2.26626454
151positive regulation of Rap GTPase activity (GO:0032854)2.23658056
152embryonic retina morphogenesis in camera-type eye (GO:0060059)2.23028805
153activation of JUN kinase activity (GO:0007257)2.22082233
154positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.21658838
155regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.21658838
156regulation of p38MAPK cascade (GO:1900744)2.19229472
157regulation of T cell tolerance induction (GO:0002664)2.18179495
158positive regulation of p38MAPK cascade (GO:1900745)2.16691579
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.15373962
160antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.15373962
161coronary vasculature morphogenesis (GO:0060977)2.14265726
162adherens junction assembly (GO:0034333)2.13732180
163response to interleukin-15 (GO:0070672)2.13377848
164regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.12859288
165positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.12859288
166regulation of chromatin binding (GO:0035561)2.11373902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.38108105
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09255372
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49811206
4* MYC_22102868_ChIP-Seq_BL_Human3.39535297
5EZH2_22144423_ChIP-Seq_EOC_Human2.96888823
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86821472
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.86554557
8TCF7_22412390_ChIP-Seq_EML_Mouse2.81393826
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64130146
10* KDM2B_26808549_Chip-Seq_DND41_Human2.62147367
11* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.61551959
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.42473761
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.38491895
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22185656
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15644484
16VDR_21846776_ChIP-Seq_THP-1_Human2.11725164
17E2F7_22180533_ChIP-Seq_HELA_Human2.02306679
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98349754
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97488465
20* MAF_26560356_Chip-Seq_TH1_Human1.91560946
21* KDM2B_26808549_Chip-Seq_JURKAT_Human1.90352614
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.87654737
23RUNX_20019798_ChIP-Seq_JUKART_Human1.87133811
24VDR_24787735_ChIP-Seq_THP-1_Human1.84422108
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.83534794
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80996065
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.79501493
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79255307
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78399479
30UTX_26944678_Chip-Seq_JUKART_Human1.78148210
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75622533
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70327948
33* KDM2B_26808549_Chip-Seq_K562_Human1.68677336
34DROSHA_22980978_ChIP-Seq_HELA_Human1.66245802
35MYB_26560356_Chip-Seq_TH1_Human1.61848778
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.59034619
37SPI1_23127762_ChIP-Seq_K562_Human1.58350114
38MYB_26560356_Chip-Seq_TH2_Human1.57509229
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55835889
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55736431
41AR_21572438_ChIP-Seq_LNCaP_Human1.53350508
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52026906
43* FOXO3_23340844_ChIP-Seq_DLD1_Human1.50323057
44* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46433145
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45502826
46NCOR1_26117541_ChIP-Seq_K562_Human1.43974275
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43529832
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43529832
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.42132400
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41022369
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38919026
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38534521
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37805797
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37655313
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37189507
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.37108873
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36266437
58GBX2_23144817_ChIP-Seq_PC3_Human1.36238449
59GATA1_22025678_ChIP-Seq_K562_Human1.36037966
60* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35089526
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34976792
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.34099326
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31689073
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30208830
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29114107
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.27578379
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27051424
68VDR_24763502_ChIP-Seq_THP-1_Human1.26074917
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24845249
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24471032
71* SMRT_27268052_Chip-Seq_Bcells_Human1.24063254
72LXR_22292898_ChIP-Seq_THP-1_Human1.23412187
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22872458
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22419756
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21505345
76* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21250290
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20793989
78FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20660673
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19980681
80* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19750087
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19448844
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19399067
83* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18981282
84SCL_19346495_ChIP-Seq_HPC-7_Human1.18966006
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18331209
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.17585915
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.17585915
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.17313473
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16889222
90* TP63_19390658_ChIP-ChIP_HaCaT_Human1.16420167
91* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16302159
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15733720
93* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12639225
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12464753
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11152235
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10929302
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10605763
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09991965
99RACK7_27058665_Chip-Seq_MCF-7_Human1.09916059
100GATA3_27048872_Chip-Seq_THYMUS_Human1.09697582
101AHR_22903824_ChIP-Seq_MCF-7_Human1.09336848
102GATA3_26560356_Chip-Seq_TH2_Human1.08985537
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08629354
104TP53_16413492_ChIP-PET_HCT116_Human1.07315768
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.06140730
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.05790344
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05608157
108* CREB1_26743006_Chip-Seq_LNCaP_Human1.05060020
109* MAF_26560356_Chip-Seq_TH2_Human1.04750814
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.04111133
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03944448
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03769890
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03682556
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03619088
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.03075031
116* REST_21632747_ChIP-Seq_MESCs_Mouse1.01965331
117* STAT3_23295773_ChIP-Seq_U87_Human1.00895784
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00480043
119GATA1_19941826_ChIP-Seq_K562_Human0.99750897
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99630962
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.99614781
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99163649
123TCF4_23295773_ChIP-Seq_U87_Human0.99108701
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98978508
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98063086
126* GATA6_25053715_ChIP-Seq_YYC3_Human0.97240704
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96502974
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95941410
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95941410
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95941410
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95110734
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94626321
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94040153
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93826996
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.93595534
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92970333
137* SMAD4_21799915_ChIP-Seq_A2780_Human0.92968761
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.92918843
139CIITA_25753668_ChIP-Seq_RAJI_Human0.92278837
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.91976542
141* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91622427
142BP1_19119308_ChIP-ChIP_Hs578T_Human0.90917747
143NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90080039
144* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89954324
145GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88454139
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86560819
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84019091
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.83419484
149STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83199306
150* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83066858
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82417282
152RXR_22108803_ChIP-Seq_LS180_Human0.82165018
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81764241
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81703885
155ESR1_20079471_ChIP-ChIP_T-47D_Human0.81412117
156PU_27001747_Chip-Seq_BMDM_Mouse0.80090386
157* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79463897
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.78606936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.48174349
2MP0000569_abnormal_digit_pigmentation3.36917594
3MP0003705_abnormal_hypodermis_morpholog2.99191449
4MP0010352_gastrointestinal_tract_polyps2.97238113
5MP0003303_peritoneal_inflammation2.87593163
6MP0003300_gastrointestinal_ulcer2.86522560
7MP0008961_abnormal_basal_metabolism2.58990300
8MP0004859_abnormal_synaptic_plasticity2.21674464
9MP0004264_abnormal_extraembryonic_tissu2.11608641
10MP0003045_fibrosis2.01092603
11MP0009278_abnormal_bone_marrow1.98563798
12MP0003724_increased_susceptibility_to1.91511399
13MP0004510_myositis1.88716564
14MP0001501_abnormal_sleep_pattern1.83264912
15MP0003566_abnormal_cell_adhesion1.82468850
16MP0002138_abnormal_hepatobiliary_system1.81359136
17MP0005025_abnormal_response_to1.77630454
18MP0000733_abnormal_muscle_development1.77570846
19MP0002396_abnormal_hematopoietic_system1.77557158
20MP0002166_altered_tumor_susceptibility1.77503526
21MP0002419_abnormal_innate_immunity1.71337795
22MP0004808_abnormal_hematopoietic_stem1.68789891
23MP0005387_immune_system_phenotype1.66499385
24MP0001790_abnormal_immune_system1.66499385
25MP0001800_abnormal_humoral_immune1.66368603
26MP0002877_abnormal_melanocyte_morpholog1.64098658
27MP0001849_ear_inflammation1.62330621
28MP0004185_abnormal_adipocyte_glucose1.61362020
29MP0002148_abnormal_hypersensitivity_rea1.61187372
30MP0000015_abnormal_ear_pigmentation1.54277210
31MP0003763_abnormal_thymus_physiology1.53614976
32MP0003787_abnormal_imprinting1.52670633
33MP0009785_altered_susceptibility_to1.49143761
34MP0003635_abnormal_synaptic_transmissio1.43320898
35MP0003091_abnormal_cell_migration1.42931838
36MP0003984_embryonic_growth_retardation1.41231415
37MP0004381_abnormal_hair_follicle1.41037606
38MP0002088_abnormal_embryonic_growth/wei1.40438041
39MP0003890_abnormal_embryonic-extraembry1.38466942
40MP0000685_abnormal_immune_system1.37995507
41MP0005670_abnormal_white_adipose1.37733643
42MP0008877_abnormal_DNA_methylation1.36663212
43MP0002398_abnormal_bone_marrow1.35795786
44MP0004947_skin_inflammation1.34136462
45MP0004197_abnormal_fetal_growth/weight/1.34093868
46MP0001672_abnormal_embryogenesis/_devel1.33739556
47MP0005380_embryogenesis_phenotype1.33739556
48MP0002086_abnormal_extraembryonic_tissu1.32477835
49MP0002006_tumorigenesis1.31832505
50MP0001835_abnormal_antigen_presentation1.29925806
51MP0005023_abnormal_wound_healing1.29902417
52MP0000703_abnormal_thymus_morphology1.29511219
53MP0002064_seizures1.29333094
54MP0008057_abnormal_DNA_replication1.28560435
55MP0002925_abnormal_cardiovascular_devel1.27792079
56MP0002009_preneoplasia1.27329512
57MP0010307_abnormal_tumor_latency1.26485484
58MP0002452_abnormal_antigen_presenting1.24089109
59MP0009745_abnormal_behavioral_response1.22684544
60MP0010630_abnormal_cardiac_muscle1.22460219
61MP0002063_abnormal_learning/memory/cond1.21690595
62MP0008569_lethality_at_weaning1.17581048
63MP0002084_abnormal_developmental_patter1.17121622
64MP0009046_muscle_twitch1.15968076
65MP0002928_abnormal_bile_duct1.14659231
66MP0004270_analgesia1.14475981
67MP0002405_respiratory_system_inflammati1.14114172
68MP0000350_abnormal_cell_proliferation1.14009697
69MP0001486_abnormal_startle_reflex1.13776740
70MP0003880_abnormal_central_pattern1.12569043
71MP0003436_decreased_susceptibility_to1.11947511
72MP0000716_abnormal_immune_system1.09914437
73MP0001851_eye_inflammation1.09577263
74MP0002420_abnormal_adaptive_immunity1.08663148
75MP0003172_abnormal_lysosome_physiology1.07264763
76MP0002723_abnormal_immune_serum1.07121744
77MP0001819_abnormal_immune_cell1.06959138
78MP0000003_abnormal_adipose_tissue1.06051062
79MP0009703_decreased_birth_body1.05745266
80MP0005623_abnormal_meninges_morphology1.05121714
81MP0003183_abnormal_peptide_metabolism1.04975613
82MP0005375_adipose_tissue_phenotype1.04848742
83MP0001845_abnormal_inflammatory_respons1.03845581
84MP0003453_abnormal_keratinocyte_physiol1.03539173
85MP0002735_abnormal_chemical_nociception1.03102493
86MP0003252_abnormal_bile_duct1.02614063
87MP0005666_abnormal_adipose_tissue1.02429000
88MP0003690_abnormal_glial_cell1.02253402
89MP0005423_abnormal_somatic_nervous1.01917856
90MP0002653_abnormal_ependyma_morphology1.00962615
91MP0001730_embryonic_growth_arrest1.00744510
92MP0000266_abnormal_heart_morphology1.00305223
93MP0001348_abnormal_lacrimal_gland1.00260406
94MP0002722_abnormal_immune_system0.97738511
95MP0002272_abnormal_nervous_system0.97504352
96MP0004087_abnormal_muscle_fiber0.97001409
97MP0000689_abnormal_spleen_morphology0.96616130
98MP0002085_abnormal_embryonic_tissue0.95916524
99MP0004233_abnormal_muscle_weight0.95811063
100MP0002254_reproductive_system_inflammat0.95458007
101MP0005671_abnormal_response_to0.94953936
102MP0005310_abnormal_salivary_gland0.93464079
103MP0004742_abnormal_vestibular_system0.93204696
104MP0001697_abnormal_embryo_size0.92590976
105MP0005000_abnormal_immune_tolerance0.91766036
106MP0003935_abnormal_craniofacial_develop0.91667907
107MP0005075_abnormal_melanosome_morpholog0.91595885
108MP0004130_abnormal_muscle_cell0.91204809
109MP0001853_heart_inflammation0.89638382
110MP0005174_abnormal_tail_pigmentation0.87919865
111MP0003115_abnormal_respiratory_system0.87772472
112MP0009672_abnormal_birth_weight0.87583954
113MP0003448_altered_tumor_morphology0.87211265
114MP0005397_hematopoietic_system_phenotyp0.86796387
115MP0001545_abnormal_hematopoietic_system0.86796387
116MP0002429_abnormal_blood_cell0.86679125
117MP0001533_abnormal_skeleton_physiology0.86500575
118MP0009780_abnormal_chondrocyte_physiolo0.86251111
119MP0002572_abnormal_emotion/affect_behav0.84542909
120MP0004484_altered_response_of0.84157200
121MP0001915_intracranial_hemorrhage0.84101675
122MP0003111_abnormal_nucleus_morphology0.83244804
123MP0003866_abnormal_defecation0.83136059
124MP0001986_abnormal_taste_sensitivity0.83046921
125MP0003633_abnormal_nervous_system0.82987945
126MP0010155_abnormal_intestine_physiology0.82486932
127MP0003828_pulmonary_edema0.82452556
128MP0002067_abnormal_sensory_capabilities0.82443994
129MP0002168_other_aberrant_phenotype0.81506318
130MP0004883_abnormal_blood_vessel0.80969426
131MP0001873_stomach_inflammation0.80817340
132MP0005464_abnormal_platelet_physiology0.80373786
133MP0000767_abnormal_smooth_muscle0.80372953
134MP0004924_abnormal_behavior0.79970468
135MP0005386_behavior/neurological_phenoty0.79970468
136MP0005645_abnormal_hypothalamus_physiol0.79416937
137MP0000465_gastrointestinal_hemorrhage0.79226288
138MP0002933_joint_inflammation0.78649486
139MP0005621_abnormal_cell_physiology0.78640084
140MP0001502_abnormal_circadian_rhythm0.77125936
141MP0001440_abnormal_grooming_behavior0.76895118
142MP0008874_decreased_physiological_sensi0.76879211
143MP0001784_abnormal_fluid_regulation0.76798822
144MP0003077_abnormal_cell_cycle0.75775281
145MP0009115_abnormal_fat_cell0.75342509
146MP0000428_abnormal_craniofacial_morphol0.74800812
147MP0002080_prenatal_lethality0.74647350
148MP0002998_abnormal_bone_remodeling0.73136159
149MP0009764_decreased_sensitivity_to0.72988445
150MP0003879_abnormal_hair_cell0.71975507
151MP0002332_abnormal_exercise_endurance0.70263943
152MP0008260_abnormal_autophagy0.70239662

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)4.56001521
2Abnormality of the fingertips (HP:0001211)3.87115475
3Febrile seizures (HP:0002373)3.32457778
4Cerebral aneurysm (HP:0004944)3.28801628
5Gastrointestinal stroma tumor (HP:0100723)3.21430340
6Obstructive sleep apnea (HP:0002870)3.07905846
7Panhypogammaglobulinemia (HP:0003139)3.06833356
8Heterotopia (HP:0002282)3.02829359
9Progressive cerebellar ataxia (HP:0002073)3.02623413
10Meningitis (HP:0001287)3.00524702
11Macroorchidism (HP:0000053)3.00212581
12Recurrent bacterial skin infections (HP:0005406)2.99053658
13Recurrent sinusitis (HP:0011108)2.92644642
14Vasculitis (HP:0002633)2.86858532
15Stomatitis (HP:0010280)2.83758469
16Mediastinal lymphadenopathy (HP:0100721)2.81408507
17Urethral obstruction (HP:0000796)2.80159315
18Recurrent bronchitis (HP:0002837)2.78156492
19Spontaneous hematomas (HP:0007420)2.72721194
20Neoplasm of the tracheobronchial system (HP:0100552)2.70801538
21Abnormality of the lower motor neuron (HP:0002366)2.66229279
22Long eyelashes (HP:0000527)2.62057354
23Short 4th metacarpal (HP:0010044)2.59521801
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59521801
25Hyperventilation (HP:0002883)2.54975876
26Recurrent cutaneous fungal infections (HP:0011370)2.53682832
27Chronic mucocutaneous candidiasis (HP:0002728)2.53682832
28Hyperacusis (HP:0010780)2.53010506
29Abnormality of binocular vision (HP:0011514)2.47828783
30Diplopia (HP:0000651)2.47828783
31Alveolar cell carcinoma (HP:0006519)2.47573070
32Atonic seizures (HP:0010819)2.46792902
33Widely spaced teeth (HP:0000687)2.45412865
34Recurrent abscess formation (HP:0002722)2.44796944
35Stomach cancer (HP:0012126)2.44008489
36Pulmonary infiltrates (HP:0002113)2.43958811
37Volvulus (HP:0002580)2.43756602
38Shallow orbits (HP:0000586)2.43693394
39Lymphopenia (HP:0001888)2.42366277
40Slow saccadic eye movements (HP:0000514)2.41215423
41Absent speech (HP:0001344)2.41129951
42Gaze-evoked nystagmus (HP:0000640)2.40523958
43Colitis (HP:0002583)2.34478384
44Retrobulbar optic neuritis (HP:0100654)2.32909662
45Optic neuritis (HP:0100653)2.32909662
46Papilloma (HP:0012740)2.32548254
47Verrucae (HP:0200043)2.32548254
48Increased IgE level (HP:0003212)2.32403843
49Difficulty running (HP:0009046)2.29695093
50Epileptic encephalopathy (HP:0200134)2.27679924
51Protruding tongue (HP:0010808)2.27038999
52Narrow palate (HP:0000189)2.26321222
53Focal seizures (HP:0007359)2.25299084
54Chest pain (HP:0100749)2.23370748
55Osteomyelitis (HP:0002754)2.20667537
56Myositis (HP:0100614)2.19519584
57Restrictive lung disease (HP:0002091)2.18187131
58Abnormality of the columella (HP:0009929)2.17372264
59Vertebral arch anomaly (HP:0008438)2.14074186
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13563881
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.13524819
62Elevated erythrocyte sedimentation rate (HP:0003565)2.11749827
63Focal motor seizures (HP:0011153)2.11389774
64Trigonocephaly (HP:0000243)2.11014028
65Recurrent viral infections (HP:0004429)2.10931901
66Prominent nose (HP:0000448)2.10080437
67Recurrent skin infections (HP:0001581)2.09932904
68Aneurysm (HP:0002617)2.09820879
69Postural instability (HP:0002172)2.06416394
70Abnormality of the astrocytes (HP:0100707)2.06248096
71Astrocytoma (HP:0009592)2.06248096
72Urinary bladder sphincter dysfunction (HP:0002839)2.05497913
73Mitral valve prolapse (HP:0001634)2.05432307
74Hepatoblastoma (HP:0002884)2.03167152
75Autoimmune thrombocytopenia (HP:0001973)2.02889492
76Abnormality of the 4th metacarpal (HP:0010012)2.02879767
77Chronic diarrhea (HP:0002028)2.02853175
78Ependymoma (HP:0002888)2.02783430
79Absent frontal sinuses (HP:0002688)2.01313955
80Aortic aneurysm (HP:0004942)2.00942555
81Emphysema (HP:0002097)2.00086627
82Encephalitis (HP:0002383)1.97738045
83Abnormality of incisor morphology (HP:0011063)1.97207963
84Subacute progressive viral hepatitis (HP:0006572)1.95562191
85Hand muscle atrophy (HP:0009130)1.95527186
86Autoimmune hemolytic anemia (HP:0001890)1.94282999
87Leukocytosis (HP:0001974)1.94250105
88Orchitis (HP:0100796)1.94043645
89Renal duplication (HP:0000075)1.93927714
90Pustule (HP:0200039)1.92971325
91Papillary thyroid carcinoma (HP:0002895)1.92445831
92Chronic hepatic failure (HP:0100626)1.92296270
93Fair hair (HP:0002286)1.91124153
94Ulnar bowing (HP:0003031)1.90711066
95Dislocated radial head (HP:0003083)1.90203096
96Hemoptysis (HP:0002105)1.89866195
97Increased nuchal translucency (HP:0010880)1.89459847
98Recurrent fungal infections (HP:0002841)1.88508816
99Neoplasm of the heart (HP:0100544)1.88269540
100Anal stenosis (HP:0002025)1.87675319
101Truncal obesity (HP:0001956)1.87336522
102Upper limb amyotrophy (HP:0009129)1.87294272
103Distal upper limb amyotrophy (HP:0007149)1.87294272
104Abnormality of T cells (HP:0002843)1.86892094
105Broad thumb (HP:0011304)1.86300051
106Abnormal delayed hypersensitivity skin test (HP:0002963)1.86001679
107Broad palm (HP:0001169)1.85929597
108Generalized hypopigmentation of hair (HP:0011358)1.85330878
109Chronic otitis media (HP:0000389)1.84234740
110Prolonged bleeding time (HP:0003010)1.83454294
111Renovascular hypertension (HP:0100817)1.83425935
112Genetic anticipation (HP:0003743)1.83107466
113Ocular albinism (HP:0001107)1.83099828
114Elfin facies (HP:0004428)1.82814439
115Nasal polyposis (HP:0100582)1.82352441
116Acute myeloid leukemia (HP:0004808)1.81623202
117Sepsis (HP:0100806)1.81203638
118Abnormality of eosinophils (HP:0001879)1.79520615
119Recurrent pneumonia (HP:0006532)1.79420068
120Increased connective tissue (HP:0009025)1.78013930
121Eosinophilia (HP:0001880)1.77249367
122Short 1st metacarpal (HP:0010034)1.77199226
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.77199226
124Keratoconjunctivitis sicca (HP:0001097)1.76800730
125Abnormality of the radial head (HP:0003995)1.75450344
126Abnormal hair whorl (HP:0010721)1.74419119
127Clumsiness (HP:0002312)1.73906709
128IgG deficiency (HP:0004315)1.73548290
129Hyporeflexia of lower limbs (HP:0002600)1.73155597
130Tented upper lip vermilion (HP:0010804)1.72739792
131Thickened helices (HP:0000391)1.72408026
132Intestinal fistula (HP:0100819)1.72174900
133Hyperkalemia (HP:0002153)1.71255320
134Supernumerary ribs (HP:0005815)1.70167090
135Disproportionate tall stature (HP:0001519)1.70159617
136Supranuclear gaze palsy (HP:0000605)1.69834841
137Transitional cell carcinoma of the bladder (HP:0006740)1.69293170
138Viral hepatitis (HP:0006562)1.68050799
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65927876
140Hypoplastic ischia (HP:0003175)1.65883642
141Agammaglobulinemia (HP:0004432)1.65674447
142Long palpebral fissure (HP:0000637)1.65355126
143Increased density of long bones (HP:0006392)1.65186700
144Obsessive-compulsive behavior (HP:0000722)1.64276172
145Sandal gap (HP:0001852)1.63947047
146Cortical dysplasia (HP:0002539)1.63227596
147Pseudobulbar signs (HP:0002200)1.62851771
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62325055
149Broad metatarsal (HP:0001783)1.62242643
150Inflammation of the large intestine (HP:0002037)1.61836096
151Lymphangioma (HP:0100764)1.61574486
152Malignant gastrointestinal tract tumors (HP:0006749)1.61571384
153Gastrointestinal carcinoma (HP:0002672)1.61571384
154Hematochezia (HP:0002573)1.61016469
155Rib fusion (HP:0000902)1.60828800
156Skin tags (HP:0010609)1.60621629
157Leiomyosarcoma (HP:0100243)1.60500574
158Uterine leiomyosarcoma (HP:0002891)1.60500574
159T lymphocytopenia (HP:0005403)1.60498065
160Myocardial infarction (HP:0001658)1.60204554
161Thick eyebrow (HP:0000574)1.59933307
162Bladder neoplasm (HP:0009725)1.58175380
163Bladder carcinoma (HP:0002862)1.58175380
164Cellulitis (HP:0100658)1.57425863
165Abnormality of the nasal mucosa (HP:0000433)1.57423066
166Short phalanx of the thumb (HP:0009660)1.57054966
167Genu recurvatum (HP:0002816)1.55609002
168Abnormality of T cell number (HP:0011839)1.55396505
169Frequent falls (HP:0002359)1.55172002
170Abnormality of the distal phalanx of the thumb (HP:0009617)1.54583657
171Limited elbow extension (HP:0001377)1.54576904
172Gastrointestinal inflammation (HP:0004386)1.54564664
173Lip pit (HP:0100267)1.54387457
174High pitched voice (HP:0001620)1.53919068
175Eczematoid dermatitis (HP:0000976)1.53528479
176Dysmetric saccades (HP:0000641)1.52100710
177Abnormality of the intervertebral disk (HP:0005108)1.50696640
178Spinal cord lesions (HP:0100561)1.50317220
179Syringomyelia (HP:0003396)1.50317220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.53621465
2RIPK43.48643039
3MAP3K103.29234335
4ERN12.58573805
5PRPF4B2.51687369
6MAP4K12.44244097
7BRD42.40581768
8TRIB32.36258053
9FRK2.14940986
10CAMK1G2.03587779
11SIK21.91854255
12RIPK11.83935392
13STK101.76132127
14EEF2K1.75793466
15BMPR21.75567549
16ICK1.70395123
17LATS11.66662744
18BLK1.66424141
19CAMK1D1.64291785
20SIK11.63717259
21DMPK1.63440250
22SYK1.61411558
23IKBKE1.60746637
24TNK21.47194879
25FGFR31.44932000
26TAOK11.44031082
27MTOR1.41670538
28IRAK41.39243993
29BTK1.39215676
30PRKD31.38690914
31NTRK31.37738281
32TTN1.34185600
33FES1.32664061
34AKT31.31804174
35JAK11.31277011
36FGFR41.30188691
37PKN21.29654475
38TAOK31.28991614
39PDGFRA1.28027922
40MAPK121.26942976
41ALK1.26886715
42CHUK1.25235589
43TEC1.24916738
44PTK61.24807058
45TYRO31.23981433
46TGFBR21.22711254
47NLK1.22666673
48GRK61.19753836
49CDK61.17229130
50SGK4941.15481847
51SGK2231.15481847
52STK381.11456180
53CSK1.11369644
54PRKCH1.09478947
55CAMKK11.09410090
56EPHB11.07639337
57MARK11.04890308
58PDGFRB1.04556650
59IRAK11.03266453
60MAP3K71.02588460
61MARK31.01266347
62SGK31.00506167
63CDC42BPA1.00043273
64MAPK130.98111235
65WNK10.97121918
66ITK0.95097510
67KIT0.94378062
68JAK30.93469790
69NEK20.92475904
70TYK20.92300286
71PRKD20.90463259
72BMX0.90199293
73MARK20.89404322
74HIPK20.86875270
75CDK30.84828639
76NTRK20.83709624
77CSF1R0.83455783
78DYRK1B0.81692229
79UHMK10.81402887
80EPHA30.80219738
81CAMK10.79798030
82CDC70.78357513
83LYN0.77826816
84PRKCQ0.77272420
85STK30.77045305
86PIK3CG0.76633658
87CSNK1A1L0.75854155
88IRAK20.75467292
89PINK10.74478331
90PTK20.73045913
91ZAP700.71083441
92HCK0.69485180
93CDK90.68881206
94NEK60.68235774
95PAK30.67334904
96CDK40.66360818
97DAPK20.66332128
98DYRK1A0.64524872
99MAP3K90.64381246
100JAK20.63792100
101CHEK10.63436324
102PIM10.62419583
103CAMK40.61877850
104MAP3K10.61545249
105MAP3K130.60855742
106CAMKK20.59056472
107TNIK0.57741116
108EPHA40.57544984
109MELK0.56799715
110LATS20.56484311
111CDK50.56291542
112PRKAA10.56232183
113DDR20.55914676
114EIF2AK30.54634871
115TRPM70.54158610
116STK40.53485422
117MAPK110.52789356
118SIK30.51795774
119MAP3K140.51209786
120RET0.50706998
121PDK10.50165398
122MAPK70.49238927
123TXK0.47787455
124STK110.47063369
125MAP3K20.45404641
126SGK20.45202248
127FGFR10.45031501
128IKBKB0.44836099
129CDK20.44667186
130PTK2B0.44246644
131YES10.44054289
132MATK0.43670175
133MAP3K60.43491820
134PKN10.42545519
135SGK10.42160379
136LRRK20.41810560
137MAPK10.41765306
138PRKD10.41763346
139PDPK10.41107992
140PRKCZ0.40248294
141MAPK140.39932912
142ATR0.39698334
143* MAPK80.39205260
144TBK10.38321816
145CSNK1D0.38307512
146ATM0.36830942
147GSK3B0.36663588
148LCK0.36064181
149MAPK100.35962393
150ABL10.35939158

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.04335518
2Lysine degradation_Homo sapiens_hsa003101.97111928
3Allograft rejection_Homo sapiens_hsa053301.85101267
4Graft-versus-host disease_Homo sapiens_hsa053321.85055376
5Autoimmune thyroid disease_Homo sapiens_hsa053201.72752438
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69236313
7Chronic myeloid leukemia_Homo sapiens_hsa052201.69020320
8Dorso-ventral axis formation_Homo sapiens_hsa043201.63448533
9Type I diabetes mellitus_Homo sapiens_hsa049401.61644877
10mTOR signaling pathway_Homo sapiens_hsa041501.60570065
11Asthma_Homo sapiens_hsa053101.57363207
12Osteoclast differentiation_Homo sapiens_hsa043801.53733584
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.51715950
14Primary immunodeficiency_Homo sapiens_hsa053401.50978815
15T cell receptor signaling pathway_Homo sapiens_hsa046601.46713735
16Type II diabetes mellitus_Homo sapiens_hsa049301.45398997
17Notch signaling pathway_Homo sapiens_hsa043301.43319992
18Long-term potentiation_Homo sapiens_hsa047201.43016631
19Viral myocarditis_Homo sapiens_hsa054161.41809313
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40891213
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39498224
22Adherens junction_Homo sapiens_hsa045201.37933991
23Insulin resistance_Homo sapiens_hsa049311.36920322
24Pancreatic cancer_Homo sapiens_hsa052121.32650463
25MicroRNAs in cancer_Homo sapiens_hsa052061.28124059
26Acute myeloid leukemia_Homo sapiens_hsa052211.27807306
27Endometrial cancer_Homo sapiens_hsa052131.26601819
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.25144252
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.23984239
30VEGF signaling pathway_Homo sapiens_hsa043701.22529107
31Toxoplasmosis_Homo sapiens_hsa051451.19265453
32Non-small cell lung cancer_Homo sapiens_hsa052231.18564681
33Colorectal cancer_Homo sapiens_hsa052101.16782022
34Small cell lung cancer_Homo sapiens_hsa052221.12954624
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11274157
36Proteoglycans in cancer_Homo sapiens_hsa052051.10696718
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09827578
38Prolactin signaling pathway_Homo sapiens_hsa049171.08042701
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07724803
40Staphylococcus aureus infection_Homo sapiens_hsa051501.07502830
41Leishmaniasis_Homo sapiens_hsa051401.06413777
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04205785
43Prostate cancer_Homo sapiens_hsa052151.03345026
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03337012
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02860465
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02611280
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00546172
48TNF signaling pathway_Homo sapiens_hsa046681.00113228
49FoxO signaling pathway_Homo sapiens_hsa040680.99917103
50Circadian rhythm_Homo sapiens_hsa047100.99834648
51Focal adhesion_Homo sapiens_hsa045100.98620552
52Amphetamine addiction_Homo sapiens_hsa050310.97795841
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97795185
54Glioma_Homo sapiens_hsa052140.97172410
55Hepatitis B_Homo sapiens_hsa051610.97144183
56Antigen processing and presentation_Homo sapiens_hsa046120.96868806
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.96126476
58Hematopoietic cell lineage_Homo sapiens_hsa046400.96116225
59Renal cell carcinoma_Homo sapiens_hsa052110.95323724
60Estrogen signaling pathway_Homo sapiens_hsa049150.93989562
61Oxytocin signaling pathway_Homo sapiens_hsa049210.93651462
62HTLV-I infection_Homo sapiens_hsa051660.92497442
63Chemokine signaling pathway_Homo sapiens_hsa040620.91808268
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.90927795
65Cholinergic synapse_Homo sapiens_hsa047250.90927562
66Measles_Homo sapiens_hsa051620.89702148
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.89604416
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89158197
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89001875
70Influenza A_Homo sapiens_hsa051640.88603048
71Glucagon signaling pathway_Homo sapiens_hsa049220.87637792
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87621851
73Hepatitis C_Homo sapiens_hsa051600.86656530
74MAPK signaling pathway_Homo sapiens_hsa040100.86326797
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85407036
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85154487
77Apoptosis_Homo sapiens_hsa042100.85141216
78Insulin signaling pathway_Homo sapiens_hsa049100.84970540
79cAMP signaling pathway_Homo sapiens_hsa040240.84248935
80Platelet activation_Homo sapiens_hsa046110.83963116
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.83620793
82Morphine addiction_Homo sapiens_hsa050320.83121062
83Circadian entrainment_Homo sapiens_hsa047130.79692495
84Viral carcinogenesis_Homo sapiens_hsa052030.79661007
85Nicotine addiction_Homo sapiens_hsa050330.79491788
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.79344461
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78827670
88Long-term depression_Homo sapiens_hsa047300.77805921
89Nitrogen metabolism_Homo sapiens_hsa009100.77550692
90mRNA surveillance pathway_Homo sapiens_hsa030150.77479550
91ErbB signaling pathway_Homo sapiens_hsa040120.77287885
92Glutamatergic synapse_Homo sapiens_hsa047240.76489854
93Herpes simplex infection_Homo sapiens_hsa051680.75803057
94Choline metabolism in cancer_Homo sapiens_hsa052310.75699457
95Renin secretion_Homo sapiens_hsa049240.73493153
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73156429
97Tuberculosis_Homo sapiens_hsa051520.72748353
98Inositol phosphate metabolism_Homo sapiens_hsa005620.72512439
99Calcium signaling pathway_Homo sapiens_hsa040200.71762028
100AMPK signaling pathway_Homo sapiens_hsa041520.71142346
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71084503
102Insulin secretion_Homo sapiens_hsa049110.70894696
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69994022
104Dilated cardiomyopathy_Homo sapiens_hsa054140.69761735
105Salivary secretion_Homo sapiens_hsa049700.69732062
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.69608010
107Pathways in cancer_Homo sapiens_hsa052000.68952518
108Rap1 signaling pathway_Homo sapiens_hsa040150.68288722
109Hippo signaling pathway_Homo sapiens_hsa043900.68129553
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67488469
111Gastric acid secretion_Homo sapiens_hsa049710.66799240
112Amoebiasis_Homo sapiens_hsa051460.66510292
113Cocaine addiction_Homo sapiens_hsa050300.66405135
114Ras signaling pathway_Homo sapiens_hsa040140.65795837
115Rheumatoid arthritis_Homo sapiens_hsa053230.65408347
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65399900
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65116782
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65054331
119Basal cell carcinoma_Homo sapiens_hsa052170.63743585
120GnRH signaling pathway_Homo sapiens_hsa049120.63033696
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62026950
122Bladder cancer_Homo sapiens_hsa052190.61756462
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61712412
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.61518002
125Dopaminergic synapse_Homo sapiens_hsa047280.60654953
126HIF-1 signaling pathway_Homo sapiens_hsa040660.60315242
127Epstein-Barr virus infection_Homo sapiens_hsa051690.59922524
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59774062
129Fatty acid biosynthesis_Homo sapiens_hsa000610.59741440
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58710634
131Shigellosis_Homo sapiens_hsa051310.57819358
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.57396876
133GABAergic synapse_Homo sapiens_hsa047270.56836675
134Endocytosis_Homo sapiens_hsa041440.56590578
135Thyroid cancer_Homo sapiens_hsa052160.55577154
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.55180647
137Wnt signaling pathway_Homo sapiens_hsa043100.54349963
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53938267

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