PRDM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.35113022
2pre-miRNA processing (GO:0031054)5.22808480
3nuclear pore organization (GO:0006999)5.20936143
4protein localization to kinetochore (GO:0034501)4.62772421
5mitotic sister chromatid cohesion (GO:0007064)4.30320369
6regulation of RNA export from nucleus (GO:0046831)4.22156034
7mitotic nuclear envelope disassembly (GO:0007077)4.16577155
8regulation of sister chromatid cohesion (GO:0007063)4.06677463
9nuclear envelope disassembly (GO:0051081)4.03097271
10membrane disassembly (GO:0030397)4.03097271
11heterochromatin organization (GO:0070828)4.00781502
12protein localization to chromosome, centromeric region (GO:0071459)3.99913116
13DNA unwinding involved in DNA replication (GO:0006268)3.90980879
14pore complex assembly (GO:0046931)3.86237738
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85707935
16regulation of spindle organization (GO:0090224)3.71818999
17regulation of translational termination (GO:0006449)3.63278261
18mitotic chromosome condensation (GO:0007076)3.62809598
19histone H2A monoubiquitination (GO:0035518)3.55280978
20regulation of histone H3-K27 methylation (GO:0061085)3.53404081
21monoubiquitinated protein deubiquitination (GO:0035520)3.48606117
22NLS-bearing protein import into nucleus (GO:0006607)3.47461752
23negative regulation of histone methylation (GO:0031061)3.46695866
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42959422
25regulation of NFAT protein import into nucleus (GO:0051532)3.39613335
26positive regulation of chromosome segregation (GO:0051984)3.36595404
27nuclear envelope organization (GO:0006998)3.32144647
28DNA replication-dependent nucleosome assembly (GO:0006335)3.30030801
29DNA replication-dependent nucleosome organization (GO:0034723)3.30030801
30regulation of nucleobase-containing compound transport (GO:0032239)3.27568583
31mitotic metaphase plate congression (GO:0007080)3.25292313
32sister chromatid segregation (GO:0000819)3.23387205
33skin morphogenesis (GO:0043589)3.22889870
34protein localization to chromosome (GO:0034502)3.21581098
35regulation of mitotic spindle organization (GO:0060236)3.21559801
36chromatin assembly (GO:0031497)3.18676351
37protein localization to microtubule (GO:0035372)3.17999073
38gene silencing by RNA (GO:0031047)3.16723295
39regulation of histone H3-K9 methylation (GO:0051570)3.15576992
40stress granule assembly (GO:0034063)3.12860777
41macroautophagy (GO:0016236)3.12767815
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.11145120
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11145120
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11145120
45N-terminal protein amino acid acetylation (GO:0006474)3.09980619
46DNA duplex unwinding (GO:0032508)3.06605508
47mitotic sister chromatid segregation (GO:0000070)3.06333137
48peptidyl-lysine dimethylation (GO:0018027)3.04724935
49DNA geometric change (GO:0032392)3.04161570
50regulation of DNA methylation (GO:0044030)3.02041571
51RNA stabilization (GO:0043489)3.01693309
52mRNA stabilization (GO:0048255)3.01693309
53ribosome assembly (GO:0042255)3.01209776
54histone H3-K4 methylation (GO:0051568)3.00307185
55histone H3-K4 trimethylation (GO:0080182)2.99261873
56chromatin assembly or disassembly (GO:0006333)2.97648715
57phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.97087012
58negative regulation of DNA repair (GO:0045738)2.96845504
59formation of translation preinitiation complex (GO:0001731)2.96203790
60folic acid-containing compound biosynthetic process (GO:0009396)2.93732389
61regulation of chromosome segregation (GO:0051983)2.92892305
62positive regulation of macroautophagy (GO:0016239)2.90711740
63regulation of translational fidelity (GO:0006450)2.89973189
64DNA replication initiation (GO:0006270)2.86549091
65regulation of Rac protein signal transduction (GO:0035020)2.84309196
66histone H3-K9 demethylation (GO:0033169)2.83863188
67IMP biosynthetic process (GO:0006188)2.83197523
68activation of Rac GTPase activity (GO:0032863)2.80604238
69hemidesmosome assembly (GO:0031581)2.80510819
70gene silencing (GO:0016458)2.80110749
71regulation of gene silencing by RNA (GO:0060966)2.79017362
72regulation of posttranscriptional gene silencing (GO:0060147)2.79017362
73regulation of gene silencing by miRNA (GO:0060964)2.79017362
74oocyte development (GO:0048599)2.78379758
75embryonic camera-type eye morphogenesis (GO:0048596)2.77870110
76DNA replication checkpoint (GO:0000076)2.77174228
77protein K6-linked ubiquitination (GO:0085020)2.74297200
78spindle assembly involved in mitosis (GO:0090307)2.74226493
79histone lysine demethylation (GO:0070076)2.73929115
80cytoplasmic mRNA processing body assembly (GO:0033962)2.71616583
81negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71105612
82chromosome condensation (GO:0030261)2.70419481
83regulation of early endosome to late endosome transport (GO:2000641)2.70029759
84histone-serine phosphorylation (GO:0035404)2.68830139
85fibroblast migration (GO:0010761)2.68053750
86metaphase plate congression (GO:0051310)2.67747558
87regulation of histone H3-K4 methylation (GO:0051569)2.66464399
88SMAD protein complex assembly (GO:0007183)2.66153668
89regulation of histone methylation (GO:0031060)2.65751775
90attachment of spindle microtubules to kinetochore (GO:0008608)2.64904973
91histone demethylation (GO:0016577)2.64892857
92glucocorticoid receptor signaling pathway (GO:0042921)2.63558512
93peptidyl-arginine omega-N-methylation (GO:0035247)2.63438748
94translesion synthesis (GO:0019985)2.62920645
95spliceosomal tri-snRNP complex assembly (GO:0000244)2.62319898
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62217532
97dosage compensation (GO:0007549)2.61550740
98trophectodermal cell differentiation (GO:0001829)2.60530526
99negative regulation of histone modification (GO:0031057)2.59955123
100hippo signaling (GO:0035329)2.59709834
101branching involved in mammary gland duct morphogenesis (GO:0060444)2.59690287
102DNA conformation change (GO:0071103)2.59476230
103regulation of telomere maintenance via telomerase (GO:0032210)2.57735770
104mRNA transport (GO:0051028)2.57552147
105positive regulation of DNA-templated transcription, initiation (GO:2000144)2.57355610
106synaptonemal complex assembly (GO:0007130)2.57170550
107regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.57038182
108mitotic G1 DNA damage checkpoint (GO:0031571)2.56423356
109DNA packaging (GO:0006323)2.56322482
110negative regulation of gene expression, epigenetic (GO:0045814)2.56056588
111mammary gland epithelial cell proliferation (GO:0033598)2.55655622
112microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.55408754
113histone H2A ubiquitination (GO:0033522)2.55213583
114regulation of hippo signaling (GO:0035330)2.55125343
115response to UV-C (GO:0010225)2.54571151
116embryonic process involved in female pregnancy (GO:0060136)2.54316923
117spindle assembly (GO:0051225)2.53076554
118spindle checkpoint (GO:0031577)2.53074479
119positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.53048705
120negative regulation of cardiac muscle hypertrophy (GO:0010614)2.52709882
121protein localization to endosome (GO:0036010)2.52243939
122insulin-like growth factor receptor signaling pathway (GO:0048009)2.51274252
123type B pancreatic cell development (GO:0003323)2.51032913
124peptidyl-arginine methylation (GO:0018216)2.50750573
125peptidyl-arginine N-methylation (GO:0035246)2.50750573
126chromatin silencing (GO:0006342)2.50394689
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.49826252
128ATP-dependent chromatin remodeling (GO:0043044)2.49308582
129paraxial mesoderm development (GO:0048339)2.48893895
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.48344724
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47925387
132regulation of chromatin binding (GO:0035561)2.47812168
133negative regulation of chromosome segregation (GO:0051985)2.47756084
134negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.47250021
135intracellular estrogen receptor signaling pathway (GO:0030520)2.47183210
136DNA replication-independent nucleosome organization (GO:0034724)2.46632530
137positive regulation of DNA-dependent DNA replication (GO:2000105)2.46076943
138peptidyl-lysine trimethylation (GO:0018023)2.45394306
139regulation of transforming growth factor beta2 production (GO:0032909)2.44379397
140positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.44113280
141embryonic eye morphogenesis (GO:0048048)2.44033478
142sphingomyelin metabolic process (GO:0006684)2.43682424
143histone H3-K9 modification (GO:0061647)2.42043043
144negative regulation of vascular permeability (GO:0043116)2.42015922
145cell-substrate junction assembly (GO:0007044)2.40107642
146ether lipid metabolic process (GO:0046485)2.39048463
147negative regulation of homotypic cell-cell adhesion (GO:0034111)2.38324866
148atrial septum morphogenesis (GO:0060413)2.37335412
149histone H3-K36 demethylation (GO:0070544)2.36951063
150protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.36244297
151face development (GO:0060324)2.36153855
152protein dealkylation (GO:0008214)2.35505782
153protein demethylation (GO:0006482)2.35505782
154positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35323824
155ER overload response (GO:0006983)2.34426208
156definitive hemopoiesis (GO:0060216)2.33708906
157negative regulation of erythrocyte differentiation (GO:0045647)2.32932491
158histone lysine methylation (GO:0034968)2.32517111
159peptidyl-threonine modification (GO:0018210)2.31250794
160negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30944439
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29420076
162embryonic foregut morphogenesis (GO:0048617)2.29011935
163positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.28853635
164glandular epithelial cell development (GO:0002068)2.27424771
165production of molecular mediator involved in inflammatory response (GO:0002532)2.24982344
166positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24872333
167COPII vesicle coating (GO:0048208)2.24845332
168histone H2B ubiquitination (GO:0033523)2.24424055
169peptidyl-threonine phosphorylation (GO:0018107)2.23560243
170artery development (GO:0060840)2.22879046
171cell-substrate adherens junction assembly (GO:0007045)2.21615370
172focal adhesion assembly (GO:0048041)2.21615370
173positive regulation of response to extracellular stimulus (GO:0032106)2.21356666
174positive regulation of response to nutrient levels (GO:0032109)2.21356666
175negative regulation of skeletal muscle tissue development (GO:0048642)2.21281677
176adherens junction assembly (GO:0034333)2.21218560
177negative regulation of muscle hypertrophy (GO:0014741)2.20444121
178negative regulation of anoikis (GO:2000811)2.18469155
179pericardium development (GO:0060039)2.18211138
180desmosome organization (GO:0002934)2.16502588
181regulation of T-helper 2 cell differentiation (GO:0045628)2.15030972
182COPI coating of Golgi vesicle (GO:0048205)2.13401033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94385259
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.13587612
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.58731571
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.76162675
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27152914
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22722725
7MYC_22102868_ChIP-Seq_BL_Human3.12105738
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04894288
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.04837047
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73326037
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71668588
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62890921
13AR_21909140_ChIP-Seq_LNCAP_Human2.58999988
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57995015
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50607046
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.47332355
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.40605731
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33884545
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.31767779
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.22698010
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.09979327
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.07819535
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01854198
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96070663
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95258080
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95258080
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91849852
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.88459233
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85633547
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82604097
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81516130
32BRD4_25478319_ChIP-Seq_HGPS_Human1.78578807
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78286097
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.77689717
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74863975
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73562485
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72496556
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72365438
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72216154
40TCF7_22412390_ChIP-Seq_EML_Mouse1.71339255
41* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70401670
42AHR_22903824_ChIP-Seq_MCF-7_Human1.70001612
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68916495
44ZNF263_19887448_ChIP-Seq_K562_Human1.66768328
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65509161
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.65321500
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63837236
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63455015
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61303661
50* TP63_19390658_ChIP-ChIP_HaCaT_Human1.60016534
51XRN2_22483619_ChIP-Seq_HELA_Human1.57342411
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56307329
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56257113
54* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.55994326
55KDM2B_26808549_Chip-Seq_DND41_Human1.54751680
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53311771
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52923433
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52770146
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52740540
60CIITA_25753668_ChIP-Seq_RAJI_Human1.50091728
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45521910
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43298263
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43253945
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41718499
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41703743
66* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41651767
67VDR_21846776_ChIP-Seq_THP-1_Human1.40736680
68* KDM5A_27292631_Chip-Seq_BREAST_Human1.40197845
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.40075574
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.38554782
71* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37765918
72* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37409500
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37110089
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.32259373
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31896511
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31389663
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.30495265
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.30495265
79KDM2B_26808549_Chip-Seq_K562_Human1.29356428
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28666680
81UTX_26944678_Chip-Seq_JUKART_Human1.26743915
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25759045
83ATF3_27146783_Chip-Seq_COLON_Human1.25528749
84* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25331562
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.25046115
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.25031571
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24883403
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23403322
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22977553
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22665088
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22590524
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.21810593
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21087887
94* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20702029
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20065023
96* TFEB_21752829_ChIP-Seq_HELA_Human1.19522065
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.18960016
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18786539
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16693313
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16286150
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15379207
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.15201470
103RACK7_27058665_Chip-Seq_MCF-7_Human1.14735217
104CHD1_26751641_Chip-Seq_LNCaP_Human1.14463815
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14448700
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13917865
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13624100
108MAF_26560356_Chip-Seq_TH1_Human1.13247353
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12502469
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12314259
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10331358
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08958308
113CJUN_26792858_Chip-Seq_BT549_Human1.08694178
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08348826
115* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07851905
116NCOR1_26117541_ChIP-Seq_K562_Human1.07381906
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07084748
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06848591
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06714247
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06588010
121NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05397048
122IRF8_27001747_Chip-Seq_BMDM_Mouse1.05158346
123TTF2_22483619_ChIP-Seq_HELA_Human1.03959138
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03857461
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03663100
126* GABP_19822575_ChIP-Seq_HepG2_Human1.02820769
127KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02030635
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01804894
129FOXA1_25552417_ChIP-Seq_VCAP_Human1.01062011
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00628902
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00021234
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.99618580
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99441636
134GATA6_25053715_ChIP-Seq_YYC3_Human0.99144953
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98610704
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98510425
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98384159
138MYB_26560356_Chip-Seq_TH2_Human0.98297477
139MYB_26560356_Chip-Seq_TH1_Human0.97411514
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97338056
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97167827
142ETS1_20019798_ChIP-Seq_JURKAT_Human0.96938020
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95619587
144VDR_23849224_ChIP-Seq_CD4+_Human0.94978622
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94938717
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94637986
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93856574
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91307074
149TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89127420
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89019168
151BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88779777
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87506027
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86540770
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86148161
155NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82865194
156CLOCK_20551151_ChIP-Seq_293T_Human0.82413949
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81602940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.59226036
2MP0003111_abnormal_nucleus_morphology3.34568058
3MP0003693_abnormal_embryo_hatching3.31065794
4MP0004957_abnormal_blastocyst_morpholog3.12311916
5MP0010094_abnormal_chromosome_stability2.97539430
6MP0003705_abnormal_hypodermis_morpholog2.91985378
7MP0003077_abnormal_cell_cycle2.87943796
8MP0005076_abnormal_cell_differentiation2.83788440
9MP0003283_abnormal_digestive_organ2.77988372
10MP0008057_abnormal_DNA_replication2.77327636
11MP0010678_abnormal_skin_adnexa2.71495083
12MP0010307_abnormal_tumor_latency2.66241463
13MP0005409_darkened_coat_color2.56414246
14MP0003123_paternal_imprinting2.47080697
15MP0001730_embryonic_growth_arrest2.40455690
16MP0000350_abnormal_cell_proliferation2.30009762
17MP0000537_abnormal_urethra_morphology2.26702383
18MP0000383_abnormal_hair_follicle2.23658257
19MP0008877_abnormal_DNA_methylation2.02101770
20MP0002009_preneoplasia2.01306017
21MP0004808_abnormal_hematopoietic_stem1.97156721
22MP0004197_abnormal_fetal_growth/weight/1.97121523
23MP0002084_abnormal_developmental_patter1.94215986
24MP0001672_abnormal_embryogenesis/_devel1.92541168
25MP0005380_embryogenesis_phenotype1.92541168
26MP0009840_abnormal_foam_cell1.91608190
27MP0010234_abnormal_vibrissa_follicle1.90057998
28MP0001697_abnormal_embryo_size1.85480085
29MP0008007_abnormal_cellular_replicative1.84422266
30MP0003121_genomic_imprinting1.83886187
31MP0003303_peritoneal_inflammation1.83162074
32MP0009278_abnormal_bone_marrow1.82639557
33MP0003984_embryonic_growth_retardation1.82075860
34MP0005451_abnormal_body_composition1.81115210
35MP0002086_abnormal_extraembryonic_tissu1.80921927
36MP0005257_abnormal_intraocular_pressure1.80681520
37MP0002088_abnormal_embryonic_growth/wei1.80611186
38MP0002796_impaired_skin_barrier1.80322181
39MP0000003_abnormal_adipose_tissue1.78739534
40MP0002085_abnormal_embryonic_tissue1.77153916
41MP0000733_abnormal_muscle_development1.77068490
42MP0002396_abnormal_hematopoietic_system1.74395228
43MP0002098_abnormal_vibrissa_morphology1.67080728
44MP0003453_abnormal_keratinocyte_physiol1.62498543
45MP0002080_prenatal_lethality1.54913804
46MP0008932_abnormal_embryonic_tissue1.46058850
47MP0005501_abnormal_skin_physiology1.45644382
48MP0001849_ear_inflammation1.43326129
49MP0009053_abnormal_anal_canal1.42311072
50MP0008058_abnormal_DNA_repair1.41759232
51MP0003567_abnormal_fetal_cardiomyocyte1.39814455
52MP0000569_abnormal_digit_pigmentation1.37486202
53MP0003890_abnormal_embryonic-extraembry1.37367889
54MP0000462_abnormal_digestive_system1.34855334
55MP0003950_abnormal_plasma_membrane1.34733533
56MP0003566_abnormal_cell_adhesion1.34126453
57MP0000427_abnormal_hair_cycle1.31870430
58MP0005623_abnormal_meninges_morphology1.31347991
59MP0003172_abnormal_lysosome_physiology1.31213980
60MP0004272_abnormal_basement_membrane1.31018725
61MP0001216_abnormal_epidermal_layer1.29377226
62MP0000428_abnormal_craniofacial_morphol1.28288423
63MP0001944_abnormal_pancreas_morphology1.27210772
64MP0000490_abnormal_crypts_of1.26450614
65MP0004185_abnormal_adipocyte_glucose1.23824429
66MP0001545_abnormal_hematopoietic_system1.23240383
67MP0005397_hematopoietic_system_phenotyp1.23240383
68MP0002653_abnormal_ependyma_morphology1.21121038
69MP0010368_abnormal_lymphatic_system1.20073019
70MP0008961_abnormal_basal_metabolism1.18004627
71MP0005375_adipose_tissue_phenotype1.15146125
72MP0002896_abnormal_bone_mineralization1.14968713
73MP0003091_abnormal_cell_migration1.14372631
74MP0000566_synostosis1.13492765
75MP0000313_abnormal_cell_death1.12736078
76MP0002019_abnormal_tumor_incidence1.11973915
77MP0000377_abnormal_hair_follicle1.10194833
78MP0003119_abnormal_digestive_system1.09772350
79MP0000703_abnormal_thymus_morphology1.09696538
80MP0001293_anophthalmia1.08096683
81MP0000767_abnormal_smooth_muscle1.07318047
82MP0000015_abnormal_ear_pigmentation1.06938816
83MP0004233_abnormal_muscle_weight1.06217976
84MP0002925_abnormal_cardiovascular_devel1.06188551
85MP0010030_abnormal_orbit_morphology1.05762285
86MP0003937_abnormal_limbs/digits/tail_de1.03623931
87MP0001346_abnormal_lacrimal_gland1.02555206
88MP0005187_abnormal_penis_morphology1.01991142
89MP0003828_pulmonary_edema1.01277525
90MP0003115_abnormal_respiratory_system0.99213204
91MP0002092_abnormal_eye_morphology0.98670455
92MP0005023_abnormal_wound_healing0.98080727
93MP0000467_abnormal_esophagus_morphology0.97491034
94MP0009703_decreased_birth_body0.97202449
95MP0006054_spinal_hemorrhage0.97055913
96MP0003191_abnormal_cellular_cholesterol0.96578744
97MP0003943_abnormal_hepatobiliary_system0.96171149
98MP0002210_abnormal_sex_determination0.95997973
99MP0009780_abnormal_chondrocyte_physiolo0.94411338
100MP0001915_intracranial_hemorrhage0.93669780
101MP0008770_decreased_survivor_rate0.93338818
102MP0002398_abnormal_bone_marrow0.92400699
103MP0000516_abnormal_urinary_system0.92137292
104MP0005367_renal/urinary_system_phenotyp0.92137292
105MP0003941_abnormal_skin_development0.91524811
106MP0003868_abnormal_feces_composition0.91316744
107MP0003656_abnormal_erythrocyte_physiolo0.91115468
108MP0002282_abnormal_trachea_morphology0.90807518
109MP0009672_abnormal_birth_weight0.90289189
110MP0005621_abnormal_cell_physiology0.89211142
111MP0003935_abnormal_craniofacial_develop0.89148432
112MP0000432_abnormal_head_morphology0.89065606
113MP0001348_abnormal_lacrimal_gland0.88904090
114MP0009115_abnormal_fat_cell0.88142835
115MP0003861_abnormal_nervous_system0.87941665
116MP0000579_abnormal_nail_morphology0.87436953
117MP0005248_abnormal_Harderian_gland0.87362828
118MP0000678_abnormal_parathyroid_gland0.86820657
119MP0003300_gastrointestinal_ulcer0.86438639
120MP0003221_abnormal_cardiomyocyte_apopto0.85545931
121MP0001145_abnormal_male_reproductive0.85074341
122MP0001929_abnormal_gametogenesis0.83400153
123MP0005058_abnormal_lysosome_morphology0.82353199
124MP0001879_abnormal_lymphatic_vessel0.82019141
125MP0003448_altered_tumor_morphology0.81453941
126MP0000858_altered_metastatic_potential0.80646194
127MP0003385_abnormal_body_wall0.79855289
128MP0000371_diluted_coat_color0.78512531
129MP0002089_abnormal_postnatal_growth/wei0.78455200
130MP0003786_premature_aging0.77897764
131MP0005384_cellular_phenotype0.77507302
132MP0003755_abnormal_palate_morphology0.77500362
133MP0009333_abnormal_splenocyte_physiolog0.77410547
134MP0003942_abnormal_urinary_system0.76680260
135MP0002722_abnormal_immune_system0.76464134
136MP0002111_abnormal_tail_morphology0.75757561
137MP0002932_abnormal_joint_morphology0.74327530
138MP0000627_abnormal_mammary_gland0.73949340
139MP0002697_abnormal_eye_size0.73724662
140MP0001727_abnormal_embryo_implantation0.73523682
141MP0000266_abnormal_heart_morphology0.72961512
142MP0002877_abnormal_melanocyte_morpholog0.72497041
143MP0003787_abnormal_imprinting0.71553175
144MP0000653_abnormal_sex_gland0.71544510
145MP0004264_abnormal_extraembryonic_tissu0.71379196
146MP0000534_abnormal_ureter_morphology0.70277022
147MP0008438_abnormal_cutaneous_collagen0.69968315
148MP0002114_abnormal_axial_skeleton0.68422310
149MP0000762_abnormal_tongue_morphology0.67561411
150MP0004782_abnormal_surfactant_physiolog0.67554128
151MP0002060_abnormal_skin_morphology0.66871662

Predicted human phenotypes

RankGene SetZ-score
1Spinal rigidity (HP:0003306)3.29594442
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28037679
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15543596
4Short 4th metacarpal (HP:0010044)3.15543596
5Volvulus (HP:0002580)3.13835997
6Deep palmar crease (HP:0006191)3.10414728
7Termporal pattern (HP:0011008)2.99273524
8Insidious onset (HP:0003587)2.99273524
9Ependymoma (HP:0002888)2.77434406
10Abnormality of the distal phalanx of the thumb (HP:0009617)2.75338258
11Curly hair (HP:0002212)2.61828432
12Increased nuchal translucency (HP:0010880)2.58960313
13Hyperacusis (HP:0010780)2.55117973
14Abnormality of the phalanges of the hallux (HP:0010057)2.51954777
15Astrocytoma (HP:0009592)2.51876704
16Abnormality of the astrocytes (HP:0100707)2.51876704
17Genu recurvatum (HP:0002816)2.51255032
18Deviation of the thumb (HP:0009603)2.48855593
19Pelvic girdle muscle weakness (HP:0003749)2.48472852
20Abnormality of the 4th metacarpal (HP:0010012)2.45981262
21Colon cancer (HP:0003003)2.43014213
22Selective tooth agenesis (HP:0001592)2.42858978
23Truncal obesity (HP:0001956)2.42350265
24Abnormality of the fingertips (HP:0001211)2.42128027
25Proximal placement of thumb (HP:0009623)2.41045456
26Thin bony cortex (HP:0002753)2.39415733
27Subacute progressive viral hepatitis (HP:0006572)2.30072486
28Ankle contracture (HP:0006466)2.28747310
29Cubitus valgus (HP:0002967)2.25566095
30Macroorchidism (HP:0000053)2.25333626
31Arterial tortuosity (HP:0005116)2.24871427
32Overgrowth (HP:0001548)2.24421541
33Dysmetric saccades (HP:0000641)2.20800208
34Shallow orbits (HP:0000586)2.20743771
35Medulloblastoma (HP:0002885)2.20353379
36Flat acetabular roof (HP:0003180)2.17317929
37Progressive sensorineural hearing impairment (HP:0000408)2.16701996
38Spinal cord lesions (HP:0100561)2.14897057
39Syringomyelia (HP:0003396)2.14897057
40Vascular tortuosity (HP:0004948)2.13500744
41Abnormality of the calcaneus (HP:0008364)2.12015596
42Short nail (HP:0001799)2.10898561
43Coarse hair (HP:0002208)2.10495882
44Germ cell neoplasia (HP:0100728)2.09456575
45Increased density of long bones (HP:0006392)2.08717766
46Overlapping toe (HP:0001845)2.08091179
47Cutaneous melanoma (HP:0012056)2.08000423
48Broad face (HP:0000283)2.07582706
49Heterotopia (HP:0002282)2.05915742
50Asymmetry of the thorax (HP:0001555)2.05519421
51Septate vagina (HP:0001153)2.05125389
52Long palpebral fissure (HP:0000637)2.02673152
53Gastrointestinal carcinoma (HP:0002672)2.01845638
54Malignant gastrointestinal tract tumors (HP:0006749)2.01845638
55Renal duplication (HP:0000075)2.01749444
56Natal tooth (HP:0000695)2.01391037
57Sparse lateral eyebrow (HP:0005338)2.01069833
58Synophrys (HP:0000664)2.01000009
59Basal cell carcinoma (HP:0002671)2.00864732
60Broad thumb (HP:0011304)2.00147006
61Rectal prolapse (HP:0002035)1.99701316
62Abnormality of the musculature of the pelvis (HP:0001469)1.99369417
63Abnormality of the hip-girdle musculature (HP:0001445)1.99369417
64Progressive hearing impairment (HP:0001730)1.99027867
65Protrusio acetabuli (HP:0003179)1.98915547
66Cervical subluxation (HP:0003308)1.98265234
67Facial hemangioma (HP:0000329)1.98189784
68Shoulder girdle muscle weakness (HP:0003547)1.98035089
69Carpal bone hypoplasia (HP:0001498)1.96258601
70Prominent nose (HP:0000448)1.95304188
71Milia (HP:0001056)1.94619396
72Rhabdomyosarcoma (HP:0002859)1.94526189
73Lip pit (HP:0100267)1.94137397
74Abnormality of the labia minora (HP:0012880)1.93697945
75Limited elbow extension (HP:0001377)1.93340361
76Low posterior hairline (HP:0002162)1.92419517
77Menstrual irregularities (HP:0000858)1.91393801
78Abnormality of incisor morphology (HP:0011063)1.91037567
79Bundle branch block (HP:0011710)1.90917760
80Sensory axonal neuropathy (HP:0003390)1.90660697
81Shawl scrotum (HP:0000049)1.90387111
82Birth length less than 3rd percentile (HP:0003561)1.89857505
83Neoplasm of striated muscle (HP:0009728)1.89739102
84Deep philtrum (HP:0002002)1.88934296
85Hyperparathyroidism (HP:0000843)1.88582791
86Long eyelashes (HP:0000527)1.88499275
87Glioma (HP:0009733)1.88179905
88Spinal muscular atrophy (HP:0007269)1.87829361
89Broad palm (HP:0001169)1.87608526
90Abnormality of the anterior horn cell (HP:0006802)1.87228665
91Degeneration of anterior horn cells (HP:0002398)1.87228665
92Thickened helices (HP:0000391)1.87103623
93Bowel diverticulosis (HP:0005222)1.87077730
94Biliary tract neoplasm (HP:0100574)1.86980620
95Thoracolumbar scoliosis (HP:0002944)1.86941755
96Transitional cell carcinoma of the bladder (HP:0006740)1.86202245
97Vertebral arch anomaly (HP:0008438)1.85940162
98Patellar aplasia (HP:0006443)1.85863180
99Absent frontal sinuses (HP:0002688)1.85635114
100Nuclear cataract (HP:0100018)1.84989781
101Cerebral aneurysm (HP:0004944)1.84709773
102Asymmetric septal hypertrophy (HP:0001670)1.84562397
103Abnormality of the thoracic spine (HP:0100711)1.84553190
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.84284820
105Hand muscle atrophy (HP:0009130)1.83578583
106Bladder neoplasm (HP:0009725)1.83050571
107Bladder carcinoma (HP:0002862)1.83050571
108Pointed chin (HP:0000307)1.82794350
109Spondylolisthesis (HP:0003302)1.82553154
110Thyroid carcinoma (HP:0002890)1.81611157
111Bicuspid aortic valve (HP:0001647)1.81500337
112Atresia of the external auditory canal (HP:0000413)1.81063508
113Uterine leiomyosarcoma (HP:0002891)1.79081037
114Leiomyosarcoma (HP:0100243)1.79081037
115Vertebral compression fractures (HP:0002953)1.78272638
116Aplasia cutis congenita (HP:0001057)1.77586933
117Difficulty climbing stairs (HP:0003551)1.76746695
118Neoplasm of the oral cavity (HP:0100649)1.76645227
119Buphthalmos (HP:0000557)1.76504671
120Mucopolysacchariduria (HP:0008155)1.76431325
121Urinary glycosaminoglycan excretion (HP:0003541)1.76431325
122Wrist flexion contracture (HP:0001239)1.76179953
123Dislocated radial head (HP:0003083)1.75691867
124Abnormality of the lower motor neuron (HP:0002366)1.75662085
125Fibrous tissue neoplasm (HP:0012316)1.75594231
126Capillary hemangiomas (HP:0005306)1.74739253
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.73877045
128Osteolytic defects of the hand bones (HP:0009699)1.73877045
129Skin tags (HP:0010609)1.73659575
130Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73572621
131Aplasia/Hypoplasia of the patella (HP:0006498)1.73514024
132Fibroma (HP:0010614)1.73291722
133Acute myeloid leukemia (HP:0004808)1.72083719
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72001275
135Abnormality of polysaccharide metabolism (HP:0011012)1.72001275
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72001275
137Abnormality of nail color (HP:0100643)1.71848156
138Short humerus (HP:0005792)1.71225553
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70964439
140Atrophic scars (HP:0001075)1.70807596
141Sandal gap (HP:0001852)1.70376531
142Obstructive sleep apnea (HP:0002870)1.70244481
143Albinism (HP:0001022)1.70131102
144Supernumerary ribs (HP:0005815)1.69531863
145Abnormality of the radial head (HP:0003995)1.69428366
146Joint laxity (HP:0001388)1.69348073
147Broad phalanges of the hand (HP:0009768)1.69192454
148Megalocornea (HP:0000485)1.67921884
149Narrow palate (HP:0000189)1.67905470
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67032984
151Aplasia/hypoplasia of the humerus (HP:0006507)1.66948520
152Low anterior hairline (HP:0000294)1.66779978
153Congenital glaucoma (HP:0001087)1.66570102
154Oligodactyly (HP:0012165)1.66002897
155Renal cell carcinoma (HP:0005584)1.65906426
156Ulnar bowing (HP:0003031)1.65741980
157Abnormality of calcium-phosphate metabolism (HP:0100530)1.65615734
158Upper limb amyotrophy (HP:0009129)1.65394492
159Distal upper limb amyotrophy (HP:0007149)1.65394492
160Neonatal hypoglycemia (HP:0001998)1.65091821
161Renovascular hypertension (HP:0100817)1.64875548
162Mitral stenosis (HP:0001718)1.64843497
163Laryngomalacia (HP:0001601)1.64462773
164Ectopic kidney (HP:0000086)1.63827763
165Distal lower limb amyotrophy (HP:0008944)1.61550996
166Open mouth (HP:0000194)1.61440141
167Patellar dislocation (HP:0002999)1.61186199
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.60640165
169Skull defect (HP:0001362)1.60078221
170Aneurysm (HP:0002617)1.59652401
171Dilatation of the ascending aorta (HP:0005111)1.59604998
172Cutis marmorata (HP:0000965)1.59481238
173Mitral valve prolapse (HP:0001634)1.59336310
174Impulsivity (HP:0100710)1.59266514
175Metaphyseal cupping (HP:0003021)1.58984103
176Papillary thyroid carcinoma (HP:0002895)1.57249137
177Amyotrophic lateral sclerosis (HP:0007354)1.56552361
178Preauricular skin tag (HP:0000384)1.54505899
179Missing ribs (HP:0000921)1.53858736
180Overriding aorta (HP:0002623)1.53750258
181Large earlobe (HP:0009748)1.52588586
182Cafe-au-lait spot (HP:0000957)1.51999876
183High pitched voice (HP:0001620)1.51943055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.79168788
2CDC73.39274156
3NEK23.07228610
4EEF2K2.87633199
5IRAK32.72537904
6MAP3K102.72466150
7TRIB32.71327869
8PKN22.65373965
9MAP3K132.52183111
10LATS22.38116667
11PRPF4B2.28793106
12LATS12.28484563
13AKT32.23704294
14ARAF2.19060068
15SIK12.10519634
16IRAK21.92882320
17NEK11.86435270
18ALK1.80563271
19WEE11.77837985
20RPS6KA41.73941106
21MOS1.73650279
22TTK1.69686756
23STK101.67647648
24STK31.66490207
25SIK31.65033506
26TTN1.60872400
27MAP3K121.59714500
28BRAF1.57739304
29MTOR1.41984577
30CDK41.40415594
31STK161.39877822
32CDK61.39531647
33PRKD21.36501669
34MAP3K81.33640297
35TAOK11.30910553
36ICK1.28145181
37MAP4K11.27845173
38RPS6KB21.25496918
39CHEK11.20232903
40PAK41.19547434
41SGK31.18560152
42CDK71.18068829
43CHEK21.15574347
44SCYL21.15390422
45ATR1.14398506
46DYRK31.14379401
47PNCK1.14334764
48PDGFRA1.13428285
49DDR21.13246679
50LRRK21.13224227
51MAP3K91.10517411
52DMPK1.09955914
53IRAK11.09535874
54MAP3K11.09285476
55BRSK21.09068223
56TRPM71.07934490
57PLK11.06838261
58PTK61.06171425
59ACVR1B1.01407987
60PLK30.97474573
61AURKB0.96114457
62BMPR20.94785756
63YES10.94756052
64TSSK60.94621816
65PAK20.93538164
66PRKD30.92831618
67EPHA20.92306410
68CDK20.90744250
69TESK10.90174900
70KSR20.88239034
71SRPK10.87923946
72ATM0.84898266
73MET0.83468234
74BMX0.83325573
75SMG10.82036692
76TYRO30.81394050
77TESK20.80879039
78CDC42BPA0.80337818
79MKNK10.80226054
80NEK90.79996046
81MARK30.79906062
82ROCK20.79403858
83MARK20.77627382
84PIM20.76908775
85PASK0.76518501
86PIM10.76389007
87IRAK40.76139025
88WNK10.74616548
89HIPK20.73426920
90TGFBR10.73241935
91MELK0.72865425
92MAP3K140.72803277
93STK240.72676867
94PDK40.72563430
95PDK30.72563430
96KSR10.70723814
97PDGFRB0.70102685
98BRD40.68644047
99MAP3K70.68559860
100SIK20.67252875
101FGFR10.67244067
102MKNK20.66963855
103MST40.66939073
104RET0.66222570
105STK380.65332965
106PDK10.64646538
107PDPK10.64192112
108NEK60.62988288
109CSNK1D0.62972077
110SGK20.62657812
111ILK0.61899804
112MAP3K50.61732900
113JAK30.61677812
114CDK10.61145060
115RIPK10.60958332
116MAPKAPK30.60566635
117MAP2K30.60196879
118BUB10.59838919
119CSNK1A1L0.56512394
120BRSK10.55541064
121MAPK110.53648288
122TGFBR20.52724037
123CLK10.52578707
124NME20.52179223
125MST1R0.51830285
126GRK60.51094233
127CSNK1E0.49234827
128AKT20.49020173
129STK40.48898683
130ZAP700.47163638
131CDK90.46557071
132ERN10.45895568
133CAMK1G0.45319438
134PRKCH0.45101409
135NTRK20.42723429
136AURKA0.41870357
137CAMK1D0.41823027
138RAF10.41159433
139MAP2K10.41119046
140RPS6KA20.40790397
141FGFR30.40726007
142MAP3K60.40256005
143PAK10.39750341
144CDK80.39459125
145PTK20.38320433
146RPS6KA10.37576984
147RPS6KB10.37007251
148CHUK0.36727187
149PRKDC0.36651468
150NTRK10.36566542
151MAP3K20.36495036
152MAP3K30.35879132
153EPHB20.34637444
154TRIM280.34118211

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.57974435
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41423812
3Cell cycle_Homo sapiens_hsa041102.31287427
4DNA replication_Homo sapiens_hsa030302.16823518
5mRNA surveillance pathway_Homo sapiens_hsa030151.94974685
6Spliceosome_Homo sapiens_hsa030401.82479355
7Chronic myeloid leukemia_Homo sapiens_hsa052201.64637598
8MicroRNAs in cancer_Homo sapiens_hsa052061.63966116
9p53 signaling pathway_Homo sapiens_hsa041151.54062680
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53370471
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53190330
12mTOR signaling pathway_Homo sapiens_hsa041501.53001056
13Inositol phosphate metabolism_Homo sapiens_hsa005621.50355061
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50284561
15Oocyte meiosis_Homo sapiens_hsa041141.45206655
16Thyroid cancer_Homo sapiens_hsa052161.44660890
17Colorectal cancer_Homo sapiens_hsa052101.43435830
18Viral carcinogenesis_Homo sapiens_hsa052031.43390933
19Mismatch repair_Homo sapiens_hsa034301.42325450
20Small cell lung cancer_Homo sapiens_hsa052221.37576584
21Circadian rhythm_Homo sapiens_hsa047101.28743426
22Viral myocarditis_Homo sapiens_hsa054161.26041282
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25217354
24Hippo signaling pathway_Homo sapiens_hsa043901.24070169
25Sphingolipid signaling pathway_Homo sapiens_hsa040711.23574711
26Base excision repair_Homo sapiens_hsa034101.22931589
27HTLV-I infection_Homo sapiens_hsa051661.22523370
28Adherens junction_Homo sapiens_hsa045201.22383022
29Endometrial cancer_Homo sapiens_hsa052131.21795143
30Dorso-ventral axis formation_Homo sapiens_hsa043201.19451008
31Hepatitis C_Homo sapiens_hsa051601.18735496
32Non-small cell lung cancer_Homo sapiens_hsa052231.18501994
33Basal transcription factors_Homo sapiens_hsa030221.18419721
34Herpes simplex infection_Homo sapiens_hsa051681.14173054
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12754449
36Epstein-Barr virus infection_Homo sapiens_hsa051691.12578638
37Pancreatic cancer_Homo sapiens_hsa052121.11783332
38TGF-beta signaling pathway_Homo sapiens_hsa043501.09889774
39VEGF signaling pathway_Homo sapiens_hsa043701.09698233
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09526700
41Glioma_Homo sapiens_hsa052141.09427937
42Proteoglycans in cancer_Homo sapiens_hsa052051.09410997
43Other glycan degradation_Homo sapiens_hsa005111.09141682
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08980722
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.08616736
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07936064
47Type II diabetes mellitus_Homo sapiens_hsa049301.07714153
48* Neurotrophin signaling pathway_Homo sapiens_hsa047221.07292218
49Antigen processing and presentation_Homo sapiens_hsa046121.07106822
50Long-term depression_Homo sapiens_hsa047301.06938384
51One carbon pool by folate_Homo sapiens_hsa006701.04877073
52Fanconi anemia pathway_Homo sapiens_hsa034601.03194334
53RNA degradation_Homo sapiens_hsa030181.03166815
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02298547
55Nucleotide excision repair_Homo sapiens_hsa034201.01761947
56Renal cell carcinoma_Homo sapiens_hsa052111.01452349
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98776319
58Acute myeloid leukemia_Homo sapiens_hsa052210.98196859
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97435558
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.96733579
61Long-term potentiation_Homo sapiens_hsa047200.95957168
62Hepatitis B_Homo sapiens_hsa051610.95065165
63GnRH signaling pathway_Homo sapiens_hsa049120.94296316
64Insulin signaling pathway_Homo sapiens_hsa049100.94101682
65AMPK signaling pathway_Homo sapiens_hsa041520.93606021
66B cell receptor signaling pathway_Homo sapiens_hsa046620.93403753
67T cell receptor signaling pathway_Homo sapiens_hsa046600.93211090
68Basal cell carcinoma_Homo sapiens_hsa052170.92010923
69Gap junction_Homo sapiens_hsa045400.91970584
70Bladder cancer_Homo sapiens_hsa052190.91485387
71Prostate cancer_Homo sapiens_hsa052150.90728795
72RNA polymerase_Homo sapiens_hsa030200.89936780
73Focal adhesion_Homo sapiens_hsa045100.89271225
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89061521
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88823558
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.88794251
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86478708
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86190405
79Estrogen signaling pathway_Homo sapiens_hsa049150.85479179
80Insulin resistance_Homo sapiens_hsa049310.85426532
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83186154
82Sphingolipid metabolism_Homo sapiens_hsa006000.82727494
83Toxoplasmosis_Homo sapiens_hsa051450.82064497
84Non-homologous end-joining_Homo sapiens_hsa034500.80299471
85Apoptosis_Homo sapiens_hsa042100.80298101
86Pathways in cancer_Homo sapiens_hsa052000.76926572
87Notch signaling pathway_Homo sapiens_hsa043300.76330730
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75659435
89Homologous recombination_Homo sapiens_hsa034400.75629447
90Measles_Homo sapiens_hsa051620.75118863
91FoxO signaling pathway_Homo sapiens_hsa040680.74578843
92HIF-1 signaling pathway_Homo sapiens_hsa040660.74355389
93Prolactin signaling pathway_Homo sapiens_hsa049170.73414765
94TNF signaling pathway_Homo sapiens_hsa046680.73367161
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72977319
96Wnt signaling pathway_Homo sapiens_hsa043100.72814150
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72394133
98Hedgehog signaling pathway_Homo sapiens_hsa043400.71435683
99Osteoclast differentiation_Homo sapiens_hsa043800.70898605
100Leishmaniasis_Homo sapiens_hsa051400.70120766
101Shigellosis_Homo sapiens_hsa051310.70012088
102Influenza A_Homo sapiens_hsa051640.68440765
103Melanoma_Homo sapiens_hsa052180.68409886
104Lysine degradation_Homo sapiens_hsa003100.68061123
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67786975
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.65998899
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65498527
108Melanogenesis_Homo sapiens_hsa049160.65042357
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64596799
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64448098
111Endocytosis_Homo sapiens_hsa041440.64169521
112MAPK signaling pathway_Homo sapiens_hsa040100.64073507
113ErbB signaling pathway_Homo sapiens_hsa040120.63949430
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63827173
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63652215
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62299162
117Legionellosis_Homo sapiens_hsa051340.62274128
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62261514
119Systemic lupus erythematosus_Homo sapiens_hsa053220.61878087
120Tight junction_Homo sapiens_hsa045300.61247348
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.61210074
122Lysosome_Homo sapiens_hsa041420.60002814
123Glucagon signaling pathway_Homo sapiens_hsa049220.59438466
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59271974
125Tuberculosis_Homo sapiens_hsa051520.59074713
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59066655
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.58840460
128Pyrimidine metabolism_Homo sapiens_hsa002400.56177052
129Rap1 signaling pathway_Homo sapiens_hsa040150.55396743
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55085801
131Amoebiasis_Homo sapiens_hsa051460.54248267
132Platelet activation_Homo sapiens_hsa046110.53956811
133ECM-receptor interaction_Homo sapiens_hsa045120.53777369
134Choline metabolism in cancer_Homo sapiens_hsa052310.52592930
135Alcoholism_Homo sapiens_hsa050340.51650294

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