PRDM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal-epithelial cell signaling (GO:0060638)4.13179152
2negative regulation of cytosolic calcium ion concentration (GO:0051481)3.92842889
3neural tube formation (GO:0001841)3.83821039
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.78854076
5response to pheromone (GO:0019236)3.76123863
6behavioral response to nicotine (GO:0035095)3.74420653
7indolalkylamine metabolic process (GO:0006586)3.74392995
8regulation of sarcomere organization (GO:0060297)3.65304460
9motile cilium assembly (GO:0044458)3.64655134
10atrial cardiac muscle cell action potential (GO:0086014)3.64225531
11kinetochore organization (GO:0051383)3.57952242
12kinetochore assembly (GO:0051382)3.57047202
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55101290
14indole-containing compound catabolic process (GO:0042436)3.54606527
15indolalkylamine catabolic process (GO:0046218)3.54606527
16tryptophan catabolic process (GO:0006569)3.54606527
17ribosomal small subunit assembly (GO:0000028)3.51835013
18DNA deamination (GO:0045006)3.47801844
19telomere maintenance via telomerase (GO:0007004)3.45762929
20regulation of gene silencing by RNA (GO:0060966)3.43083187
21regulation of posttranscriptional gene silencing (GO:0060147)3.43083187
22regulation of gene silencing by miRNA (GO:0060964)3.43083187
23kynurenine metabolic process (GO:0070189)3.37427051
24paraxial mesoderm development (GO:0048339)3.35190616
25IMP biosynthetic process (GO:0006188)3.35038335
26regulation of hippo signaling (GO:0035330)3.32495970
27regulation of helicase activity (GO:0051095)3.27144001
28photoreceptor cell maintenance (GO:0045494)3.26195452
29DNA double-strand break processing (GO:0000729)3.25549040
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.25357404
31tryptophan metabolic process (GO:0006568)3.24356876
32prenylation (GO:0097354)3.23559068
33protein prenylation (GO:0018342)3.23559068
34polyketide metabolic process (GO:0030638)3.21757396
35doxorubicin metabolic process (GO:0044598)3.21757396
36daunorubicin metabolic process (GO:0044597)3.21757396
37definitive hemopoiesis (GO:0060216)3.20423283
38cilium or flagellum-dependent cell motility (GO:0001539)3.19447497
39signal peptide processing (GO:0006465)3.16917005
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.15983927
41negative regulation of translation, ncRNA-mediated (GO:0040033)3.12530384
42regulation of translation, ncRNA-mediated (GO:0045974)3.12530384
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12530384
44centriole assembly (GO:0098534)3.09767639
45telomere maintenance via telomere lengthening (GO:0010833)3.08982876
46epithelial cilium movement (GO:0003351)3.08051649
47cilium morphogenesis (GO:0060271)3.06906862
48behavioral response to ethanol (GO:0048149)3.06429146
49double-strand break repair via homologous recombination (GO:0000724)3.05931300
50replication fork processing (GO:0031297)3.05316668
51recombinational repair (GO:0000725)3.03989922
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01682567
53platelet dense granule organization (GO:0060155)3.01436606
54lymphoid progenitor cell differentiation (GO:0002320)3.00497020
55reciprocal meiotic recombination (GO:0007131)2.98363082
56reciprocal DNA recombination (GO:0035825)2.98363082
57IMP metabolic process (GO:0046040)2.97215166
58cilium organization (GO:0044782)2.96773972
59cilium movement (GO:0003341)2.96018255
60telomere maintenance via semi-conservative replication (GO:0032201)2.91883624
61notochord development (GO:0030903)2.90896108
62cilium assembly (GO:0042384)2.90784794
63pyrimidine dimer repair (GO:0006290)2.89594336
64intra-S DNA damage checkpoint (GO:0031573)2.89256178
65detection of light stimulus involved in sensory perception (GO:0050962)2.88812148
66detection of light stimulus involved in visual perception (GO:0050908)2.88812148
67RNA-dependent DNA replication (GO:0006278)2.88635542
68DNA replication initiation (GO:0006270)2.87730135
69negative regulation of telomere maintenance (GO:0032205)2.86332308
70centriole replication (GO:0007099)2.86098252
71regulation of non-canonical Wnt signaling pathway (GO:2000050)2.82898807
72regulation of action potential (GO:0098900)2.82651391
73reflex (GO:0060004)2.82353093
74DNA unwinding involved in DNA replication (GO:0006268)2.80606954
75telomere maintenance (GO:0000723)2.79416794
76telomere organization (GO:0032200)2.78429142
77hematopoietic stem cell proliferation (GO:0071425)2.78136063
78cellular ketone body metabolic process (GO:0046950)2.77772254
79mesenchymal cell differentiation involved in renal system development (GO:2001012)2.77243785
80mesenchymal cell differentiation involved in kidney development (GO:0072161)2.77243785
81inner ear receptor stereocilium organization (GO:0060122)2.75876155
82mesenchymal cell proliferation (GO:0010463)2.75088049
83embryonic skeletal joint morphogenesis (GO:0060272)2.75044565
84monoubiquitinated protein deubiquitination (GO:0035520)2.74525433
85dermatan sulfate metabolic process (GO:0030205)2.74249452
86axoneme assembly (GO:0035082)2.73125640
87mitotic metaphase plate congression (GO:0007080)2.73121704
88kidney morphogenesis (GO:0060993)2.71935334
89G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71603978
90metanephric mesenchyme development (GO:0072075)2.71528251
91DNA strand elongation (GO:0022616)2.70352483
92CENP-A containing nucleosome assembly (GO:0034080)2.69175698
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69151511
94mismatch repair (GO:0006298)2.68560602
95protein localization to kinetochore (GO:0034501)2.68319265
96indole-containing compound metabolic process (GO:0042430)2.67989810
97cell proliferation involved in kidney development (GO:0072111)2.67006440
98respiratory chain complex IV assembly (GO:0008535)2.66809227
99DNA strand elongation involved in DNA replication (GO:0006271)2.66210964
100gonadal mesoderm development (GO:0007506)2.66175561
101positive regulation of male gonad development (GO:2000020)2.65656389
102retinal rod cell development (GO:0046548)2.64120047
103chondrocyte proliferation (GO:0035988)2.63763856
104dermatan sulfate biosynthetic process (GO:0030208)2.63236498
105metaphase plate congression (GO:0051310)2.63152761
106positive regulation of DNA-dependent DNA replication (GO:2000105)2.63096546
107negative regulation of DNA recombination (GO:0045910)2.62991331
108chromatin remodeling at centromere (GO:0031055)2.62111205
109peptidyl-histidine modification (GO:0018202)2.61513581
110ketone body metabolic process (GO:1902224)2.60886470
111poly(A)+ mRNA export from nucleus (GO:0016973)2.60851267
112ribosome biogenesis (GO:0042254)2.60705668
113regulation of mitotic spindle checkpoint (GO:1903504)2.60433100
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60433100
115telomere maintenance via recombination (GO:0000722)2.60399270
116piRNA metabolic process (GO:0034587)2.59667664
117regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.59630661
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.59400333
119pseudouridine synthesis (GO:0001522)2.58778345
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.57620236
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.57615966
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57615966
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.56419680
124auditory receptor cell stereocilium organization (GO:0060088)2.55750997
125viral mRNA export from host cell nucleus (GO:0046784)2.55712788
126mesenchyme morphogenesis (GO:0072132)2.55625092
127nonmotile primary cilium assembly (GO:0035058)2.55378348
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55294543
129regulation of centriole replication (GO:0046599)2.52145677
130sulfation (GO:0051923)2.52008893
131negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.51907512
132postreplication repair (GO:0006301)2.51886958
133outer ear morphogenesis (GO:0042473)2.51202105
134bone trabecula formation (GO:0060346)2.51060651
135mitochondrial RNA metabolic process (GO:0000959)2.50728493
136regulation of telomere maintenance (GO:0032204)2.50717820
137RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49772115
138retinal cone cell development (GO:0046549)2.49738668
139L-fucose catabolic process (GO:0042355)2.49565054
140fucose catabolic process (GO:0019317)2.49565054
141L-fucose metabolic process (GO:0042354)2.49565054
142male sex determination (GO:0030238)2.49379776
143cellular component assembly involved in morphogenesis (GO:0010927)2.49348930
144mitotic recombination (GO:0006312)2.49335169
145protein K6-linked ubiquitination (GO:0085020)2.48569981
146nucleobase biosynthetic process (GO:0046112)2.48202105
147regulation of double-strand break repair (GO:2000779)2.46866678
148tRNA methylation (GO:0030488)2.46506816
149smooth muscle tissue development (GO:0048745)2.45914918
150establishment of protein localization to Golgi (GO:0072600)2.45847870
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45304105
152regulation of hexokinase activity (GO:1903299)2.44121194
153regulation of glucokinase activity (GO:0033131)2.44121194
154DNA strand renaturation (GO:0000733)2.43851560
155intraciliary transport (GO:0042073)2.43849374
156nuclear pore organization (GO:0006999)2.43767859
157regulation of male gonad development (GO:2000018)2.43636035
158somite development (GO:0061053)2.43184629
159endothelium development (GO:0003158)2.42788330
160kidney mesenchyme development (GO:0072074)2.42038787
161embryonic epithelial tube formation (GO:0001838)2.41992877
162limb bud formation (GO:0060174)2.40757537
163amine catabolic process (GO:0009310)2.40094673
164cellular biogenic amine catabolic process (GO:0042402)2.40094673
165protein K11-linked deubiquitination (GO:0035871)2.39901126
166detection of mechanical stimulus involved in sensory perception (GO:0050974)2.39622461
167somatic recombination of immunoglobulin gene segments (GO:0016447)2.39022884
168tachykinin receptor signaling pathway (GO:0007217)2.38934116
169cellular response to ATP (GO:0071318)2.38893184
170cellular response to sterol (GO:0036315)2.38218127
171meiotic chromosome segregation (GO:0045132)2.38197847
172blood vessel maturation (GO:0001955)2.37382524
173neuronal action potential (GO:0019228)2.36922632
174cell differentiation involved in metanephros development (GO:0072202)2.36624614
175establishment of integrated proviral latency (GO:0075713)2.36591679
176histone H4-K12 acetylation (GO:0043983)2.36400292
177acrosome assembly (GO:0001675)2.35444160
178presynaptic membrane assembly (GO:0097105)2.35399115
179replicative senescence (GO:0090399)2.35143224
180epithelial tube formation (GO:0072175)2.34942864
181cell proliferation involved in metanephros development (GO:0072203)2.34589364
182negative regulation of mast cell activation (GO:0033004)2.33739536
183UDP-N-acetylglucosamine metabolic process (GO:0006047)2.33477065
184DNA integration (GO:0015074)2.33029693
185regulation of skeletal muscle contraction (GO:0014819)2.32945220
186regulation of mesoderm development (GO:2000380)2.32686899
187positive regulation of developmental pigmentation (GO:0048087)2.32436079
188purine nucleobase biosynthetic process (GO:0009113)2.31130590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.29475871
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.62337034
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.73172197
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40627240
5ZNF274_21170338_ChIP-Seq_K562_Hela3.12546380
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.95610058
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88515627
8* VDR_22108803_ChIP-Seq_LS180_Human2.80758911
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77667480
10IGF1R_20145208_ChIP-Seq_DFB_Human2.55945877
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.50626751
12TAF15_26573619_Chip-Seq_HEK293_Human2.45553024
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.42740550
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39002100
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33948430
16* P300_19829295_ChIP-Seq_ESCs_Human2.33694840
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29819742
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29819742
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29819742
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27178107
21FUS_26573619_Chip-Seq_HEK293_Human2.25166552
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20495316
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.18323136
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18084182
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17507998
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17132034
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16672519
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.15188073
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05143441
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98580872
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98195978
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.94585626
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.93778134
34* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92704358
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89789256
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88923243
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88345983
38ER_23166858_ChIP-Seq_MCF-7_Human1.87922028
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.86032473
40IRF1_19129219_ChIP-ChIP_H3396_Human1.83908127
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.83503792
42SMAD4_21799915_ChIP-Seq_A2780_Human1.81593655
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81581549
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80180917
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78039906
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76787692
47STAT3_23295773_ChIP-Seq_U87_Human1.75192701
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74751737
49* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73053454
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72770915
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71480306
52GBX2_23144817_ChIP-Seq_PC3_Human1.71274697
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68829468
54BCAT_22108803_ChIP-Seq_LS180_Human1.68701683
55ELK1_19687146_ChIP-ChIP_HELA_Human1.67204325
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.64871143
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64740251
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.64452626
59EWS_26573619_Chip-Seq_HEK293_Human1.62807087
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61793198
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.59999537
62CBP_20019798_ChIP-Seq_JUKART_Human1.58890956
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58890956
64TCF4_23295773_ChIP-Seq_U87_Human1.58425087
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58020155
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54628467
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54354713
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54354713
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53158470
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53091714
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.50785721
72EZH2_22144423_ChIP-Seq_EOC_Human1.50077996
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48329708
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46159316
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45145158
76AR_25329375_ChIP-Seq_VCAP_Human1.42338628
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41802908
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40858788
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40272316
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40240933
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39804875
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.39141077
83TCF4_22108803_ChIP-Seq_LS180_Human1.38715194
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38698297
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36895375
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.35822367
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35291357
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33009217
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.32095835
90NANOG_19829295_ChIP-Seq_ESCs_Human1.31715004
91SOX2_19829295_ChIP-Seq_ESCs_Human1.31715004
92RUNX2_22187159_ChIP-Seq_PCA_Human1.31696749
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31048251
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30776490
95AR_21909140_ChIP-Seq_LNCAP_Human1.29496438
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28699884
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28515665
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24553314
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24392870
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24272724
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23324480
102P53_22387025_ChIP-Seq_ESCs_Mouse1.22951318
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.22617516
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.21716969
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21217007
106TTF2_22483619_ChIP-Seq_HELA_Human1.21198567
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19197256
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.18905302
109EST1_17652178_ChIP-ChIP_JURKAT_Human1.18876942
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18207071
111NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17954771
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17618260
113CDX2_22108803_ChIP-Seq_LS180_Human1.16808128
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.16404529
115TP53_22573176_ChIP-Seq_HFKS_Human1.16077038
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15809466
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15001114
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14990261
119VDR_23849224_ChIP-Seq_CD4+_Human1.14428590
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14256146
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14079607
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13690646
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13201759
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11942167
125SCL_19346495_ChIP-Seq_HPC-7_Human1.11738764
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11671130
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11300670
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.11001712
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09398701
130P300_18555785_Chip-Seq_ESCs_Mouse1.09264006
131XRN2_22483619_ChIP-Seq_HELA_Human1.09150056
132RNF2_27304074_Chip-Seq_NSC_Mouse1.08972817
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.08765935
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08735984
135CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08480247
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08188970
137NANOG_16153702_ChIP-ChIP_HESCs_Human1.08152030
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.07638073
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07384506
140NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07173374
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06396217
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05911186
143HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04845301
144E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04354220
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04290509
146MYC_18940864_ChIP-ChIP_HL60_Human1.03854637
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03156768
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02127264
149JUN_21703547_ChIP-Seq_K562_Human1.01886800
150OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01419398
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01351833
152KDM2B_26808549_Chip-Seq_REH_Human1.01342840
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01330383
154PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01277162
155* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01024611
156FOXP3_21729870_ChIP-Seq_TREG_Human0.99055733
157SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98913022
158HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97176290
159RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96983700
160BRD4_25478319_ChIP-Seq_HGPS_Human0.96418783
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.95943912
162NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95532497
163ETS1_20019798_ChIP-Seq_JURKAT_Human0.94529047
164BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94498179
165CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94054812
166SOX2_16153702_ChIP-ChIP_HESCs_Human0.93471375
167* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92934824
168DCP1A_22483619_ChIP-Seq_HELA_Human0.91861707
169EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91796520
170RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91098299
171GABP_17652178_ChIP-ChIP_JURKAT_Human0.90030360
172TP53_16413492_ChIP-PET_HCT116_Human0.89902696
173PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88806309
174AR_21572438_ChIP-Seq_LNCaP_Human0.86057667
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85832122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology3.79115211
2MP0000569_abnormal_digit_pigmentation3.30402514
3MP0010030_abnormal_orbit_morphology3.29529943
4MP0008438_abnormal_cutaneous_collagen2.94987947
5MP0001188_hyperpigmentation2.91496804
6MP0003195_calcinosis2.77011061
7MP0006292_abnormal_olfactory_placode2.76628900
8MP0003136_yellow_coat_color2.69134761
9MP0000566_synostosis2.65032916
10MP0005248_abnormal_Harderian_gland2.56266266
11MP0004133_heterotaxia2.15161722
12MP0000427_abnormal_hair_cycle2.14414847
13MP0003279_aneurysm2.12557858
14MP0010094_abnormal_chromosome_stability2.08790021
15MP0002837_dystrophic_cardiac_calcinosis2.07391318
16MP0001968_abnormal_touch/_nociception2.02329558
17MP0002736_abnormal_nociception_after2.00398589
18MP0000049_abnormal_middle_ear2.00067841
19MP0008007_abnormal_cellular_replicative1.89364187
20MP0003941_abnormal_skin_development1.87917777
21MP0009046_muscle_twitch1.87798350
22MP0001346_abnormal_lacrimal_gland1.85787963
23MP0002249_abnormal_larynx_morphology1.84021800
24MP0005508_abnormal_skeleton_morphology1.83029256
25MP0009384_cardiac_valve_regurgitation1.81809554
26MP0003890_abnormal_embryonic-extraembry1.80349456
27MP0008058_abnormal_DNA_repair1.76429545
28MP0004134_abnormal_chest_morphology1.72980109
29MP0002938_white_spotting1.70369775
30MP0009250_abnormal_appendicular_skeleto1.70050632
31MP0008057_abnormal_DNA_replication1.68061413
32MP0001485_abnormal_pinna_reflex1.67695480
33MP0009697_abnormal_copulation1.66102887
34MP0003111_abnormal_nucleus_morphology1.65150252
35MP0001293_anophthalmia1.64959983
36MP0005646_abnormal_pituitary_gland1.63768197
37MP0003787_abnormal_imprinting1.62152532
38MP0001501_abnormal_sleep_pattern1.58167087
39MP0005171_absent_coat_pigmentation1.57703234
40MP0002282_abnormal_trachea_morphology1.57675971
41MP0000631_abnormal_neuroendocrine_gland1.54679325
42MP0005084_abnormal_gallbladder_morpholo1.51328182
43MP0003950_abnormal_plasma_membrane1.51075312
44MP0000383_abnormal_hair_follicle1.50018157
45MP0004215_abnormal_myocardial_fiber1.48499597
46MP0005174_abnormal_tail_pigmentation1.46178427
47MP0001486_abnormal_startle_reflex1.45597510
48MP0006276_abnormal_autonomic_nervous1.44655434
49MP0002089_abnormal_postnatal_growth/wei1.44574718
50MP0009745_abnormal_behavioral_response1.42169183
51MP0002396_abnormal_hematopoietic_system1.39862289
52MP0005275_abnormal_skin_tensile1.39590072
53MP0003937_abnormal_limbs/digits/tail_de1.38066004
54MP0002233_abnormal_nose_morphology1.38061951
55MP0003077_abnormal_cell_cycle1.37935241
56MP0008872_abnormal_physiological_respon1.36775890
57MP0001984_abnormal_olfaction1.36647401
58MP0000428_abnormal_craniofacial_morphol1.36354228
59MP0004043_abnormal_pH_regulation1.35246888
60MP0002932_abnormal_joint_morphology1.34594897
61MP0010386_abnormal_urinary_bladder1.33030359
62MP0004142_abnormal_muscle_tone1.32218427
63MP0003880_abnormal_central_pattern1.28406520
64MP0000372_irregular_coat_pigmentation1.26722712
65MP0002108_abnormal_muscle_morphology1.24250940
66MP0003718_maternal_effect1.23383591
67MP0003646_muscle_fatigue1.21623914
68MP0004145_abnormal_muscle_electrophysio1.21458912
69MP0004147_increased_porphyrin_level1.21214526
70MP0000762_abnormal_tongue_morphology1.20634471
71MP0002928_abnormal_bile_duct1.19313228
72MP0008877_abnormal_DNA_methylation1.19312012
73MP0004272_abnormal_basement_membrane1.18727389
74MP0002109_abnormal_limb_morphology1.17071551
75MP0004957_abnormal_blastocyst_morpholog1.15565685
76MP0000432_abnormal_head_morphology1.15400632
77MP0005645_abnormal_hypothalamus_physiol1.15237269
78MP0006072_abnormal_retinal_apoptosis1.15190625
79MP0001958_emphysema1.14809396
80MP0005551_abnormal_eye_electrophysiolog1.14259066
81MP0002653_abnormal_ependyma_morphology1.13467156
82MP0002272_abnormal_nervous_system1.11554266
83MP0003283_abnormal_digestive_organ1.11547375
84MP0003755_abnormal_palate_morphology1.11064040
85MP0003935_abnormal_craniofacial_develop1.08629326
86MP0002254_reproductive_system_inflammat1.08300723
87MP0003252_abnormal_bile_duct1.08051504
88MP0003385_abnormal_body_wall1.07914836
89MP0002075_abnormal_coat/hair_pigmentati1.07739717
90MP0002116_abnormal_craniofacial_bone1.06967579
91MP0003567_abnormal_fetal_cardiomyocyte1.06692245
92MP0000163_abnormal_cartilage_morphology1.05368498
93MP0010368_abnormal_lymphatic_system1.05224352
94MP0002697_abnormal_eye_size1.04287779
95MP0000516_abnormal_urinary_system1.03989870
96MP0005367_renal/urinary_system_phenotyp1.03989870
97MP0001286_abnormal_eye_development1.03988393
98MP0003119_abnormal_digestive_system1.03242883
99MP0003011_delayed_dark_adaptation1.03210584
100MP0001986_abnormal_taste_sensitivity1.03173337
101MP0002095_abnormal_skin_pigmentation1.02524862
102MP0004808_abnormal_hematopoietic_stem1.02194717
103MP0001529_abnormal_vocalization1.00732821
104MP0002160_abnormal_reproductive_system1.00093215
105MP0004885_abnormal_endolymph0.99412111
106MP0005253_abnormal_eye_physiology0.98948016
107MP0008932_abnormal_embryonic_tissue0.98879558
108MP0003878_abnormal_ear_physiology0.98355805
109MP0005377_hearing/vestibular/ear_phenot0.98355805
110MP0003137_abnormal_impulse_conducting0.97213972
111MP0005075_abnormal_melanosome_morpholog0.96356101
112MP0002067_abnormal_sensory_capabilities0.95764056
113MP0003121_genomic_imprinting0.95681316
114MP0002114_abnormal_axial_skeleton0.95200425
115MP0005195_abnormal_posterior_eye0.94130952
116MP0003786_premature_aging0.93524503
117MP0002234_abnormal_pharynx_morphology0.93350394
118MP0003942_abnormal_urinary_system0.93237006
119MP0002572_abnormal_emotion/affect_behav0.92279882
120MP0003115_abnormal_respiratory_system0.92048166
121MP0005391_vision/eye_phenotype0.91928124
122MP0000733_abnormal_muscle_development0.91644914
123MP0002638_abnormal_pupillary_reflex0.90965447
124MP0008775_abnormal_heart_ventricle0.90136562
125MP0001186_pigmentation_phenotype0.89889100
126MP0005389_reproductive_system_phenotype0.89604492
127MP0003698_abnormal_male_reproductive0.88986321
128MP0002115_abnormal_skeleton_extremities0.88240587
129MP0000647_abnormal_sebaceous_gland0.88221604
130MP0002557_abnormal_social/conspecific_i0.88187310
131MP0003693_abnormal_embryo_hatching0.86843375
132MP0000749_muscle_degeneration0.86274297
133MP0004084_abnormal_cardiac_muscle0.86248859
134MP0001929_abnormal_gametogenesis0.85737963
135MP0002111_abnormal_tail_morphology0.85632384
136MP0004924_abnormal_behavior0.85297330
137MP0005386_behavior/neurological_phenoty0.85297330
138MP0005187_abnormal_penis_morphology0.84415211
139MP0001175_abnormal_lung_morphology0.84316881
140MP0010678_abnormal_skin_adnexa0.83108425
141MP0000534_abnormal_ureter_morphology0.83073160
142MP0000230_abnormal_systemic_arterial0.82833402
143MP0002177_abnormal_outer_ear0.82790758
144MP0002113_abnormal_skeleton_development0.82299908
145MP0002163_abnormal_gland_morphology0.82244762
146MP0001324_abnormal_eye_pigmentation0.81960235
147MP0004085_abnormal_heartbeat0.81272601
148MP0002102_abnormal_ear_morphology0.80776610
149MP0002752_abnormal_somatic_nervous0.79911099
150MP0001299_abnormal_eye_distance/0.79641065
151MP0005395_other_phenotype0.79564476
152MP0002733_abnormal_thermal_nociception0.79448748
153MP0003943_abnormal_hepatobiliary_system0.78746184
154MP0003123_paternal_imprinting0.78668649
155MP0002210_abnormal_sex_determination0.78235432
156MP0005379_endocrine/exocrine_gland_phen0.78040548
157MP0000653_abnormal_sex_gland0.77919719
158MP0005390_skeleton_phenotype0.77908261
159MP0002085_abnormal_embryonic_tissue0.77342883
160MP0005410_abnormal_fertilization0.76895531
161MP0000750_abnormal_muscle_regeneration0.76333859
162MP0002084_abnormal_developmental_patter0.76283728
163MP0004233_abnormal_muscle_weight0.75977344
164MP0010352_gastrointestinal_tract_polyps0.75590895
165MP0000015_abnormal_ear_pigmentation0.75581732
166MP0002751_abnormal_autonomic_nervous0.75265592
167MP0005623_abnormal_meninges_morphology0.74988478
168MP0001879_abnormal_lymphatic_vessel0.74908919
169MP0001873_stomach_inflammation0.74346843
170MP0000350_abnormal_cell_proliferation0.73929606
171MP0006054_spinal_hemorrhage0.73746886

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.50888186
2Pancreatic fibrosis (HP:0100732)4.14134221
3Abnormality of midbrain morphology (HP:0002418)3.70592740
4Molar tooth sign on MRI (HP:0002419)3.70592740
5Abnormality of the renal cortex (HP:0011035)3.66245866
6Selective tooth agenesis (HP:0001592)3.41478310
7Nephronophthisis (HP:0000090)3.38241627
8Chronic hepatic failure (HP:0100626)3.34372845
9Neonatal short-limb short stature (HP:0008921)3.29011676
10Short middle phalanx of the 5th finger (HP:0004220)3.27330446
11Gaze-evoked nystagmus (HP:0000640)3.22640588
12Abnormality of the renal medulla (HP:0100957)3.15480703
13Septo-optic dysplasia (HP:0100842)3.14550270
14Type II lissencephaly (HP:0007260)3.12768113
15Medial flaring of the eyebrow (HP:0010747)3.05728785
16Attenuation of retinal blood vessels (HP:0007843)2.91135580
17Protrusio acetabuli (HP:0003179)2.91000068
18Renal cortical cysts (HP:0000803)2.82902237
19Aplasia/Hypoplasia of the tibia (HP:0005772)2.77869380
20Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.76655511
21Hyperventilation (HP:0002883)2.76510767
22Abnormality of DNA repair (HP:0003254)2.72005073
23Cervical subluxation (HP:0003308)2.70840353
24Cystic liver disease (HP:0006706)2.68755849
25Genetic anticipation (HP:0003743)2.65829792
26Tubular atrophy (HP:0000092)2.61780952
27Vitreoretinal degeneration (HP:0000655)2.57704040
28Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.55895021
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.55612088
30Chromsome breakage (HP:0040012)2.53870348
31Abnormality of the phalanges of the 5th finger (HP:0004213)2.50328968
32Abolished electroretinogram (ERG) (HP:0000550)2.47009913
33Supernumerary spleens (HP:0009799)2.46408156
34Abnormality of the columella (HP:0009929)2.45386668
35Genital tract atresia (HP:0001827)2.45271006
36Abnormality of the labia minora (HP:0012880)2.44336449
37Aplasia involving bones of the extremities (HP:0009825)2.43972392
38Aplasia involving bones of the upper limbs (HP:0009823)2.43972392
39Aplasia of the phalanges of the hand (HP:0009802)2.43972392
40Progressive inability to walk (HP:0002505)2.42981296
41Inability to walk (HP:0002540)2.38719836
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38374775
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36535945
44Cerebellar dysplasia (HP:0007033)2.36441503
45Progressive cerebellar ataxia (HP:0002073)2.35075168
46True hermaphroditism (HP:0010459)2.35004082
47Vaginal atresia (HP:0000148)2.34372957
48Congenital primary aphakia (HP:0007707)2.33871668
49Syringomyelia (HP:0003396)2.33808395
50Spinal cord lesions (HP:0100561)2.33808395
51Hypoplasia of the pons (HP:0012110)2.33333472
52Gait imbalance (HP:0002141)2.33084818
53Volvulus (HP:0002580)2.31154740
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.30737281
55Irregular epiphyses (HP:0010582)2.29169503
56Flat capital femoral epiphysis (HP:0003370)2.29114622
57Febrile seizures (HP:0002373)2.25910062
58Congenital stationary night blindness (HP:0007642)2.25588966
59Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.25083851
60Abnormality of the pons (HP:0007361)2.24733270
61Colon cancer (HP:0003003)2.24619001
62Abnormal drinking behavior (HP:0030082)2.23706489
63Polydipsia (HP:0001959)2.23706489
64Congenital hepatic fibrosis (HP:0002612)2.22792206
65Hypothermia (HP:0002045)2.22158684
66Short 5th finger (HP:0009237)2.21492523
67Bony spicule pigmentary retinopathy (HP:0007737)2.21154687
68Calf muscle hypertrophy (HP:0008981)2.20603619
69Abnormal sex determination (HP:0012244)2.20589471
70Sex reversal (HP:0012245)2.20589471
71Abnormal ciliary motility (HP:0012262)2.19241204
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.18623522
73Absent/shortened dynein arms (HP:0200106)2.18623522
74Intestinal atresia (HP:0011100)2.18186453
75Hypoplastic ischia (HP:0003175)2.17018081
76Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14348486
77Protruding tongue (HP:0010808)2.14040341
78Mesomelia (HP:0003027)2.13689704
79Meckel diverticulum (HP:0002245)2.12557221
80Postaxial foot polydactyly (HP:0001830)2.12529539
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11767279
82Abnormality of alanine metabolism (HP:0010916)2.11767279
83Hyperalaninemia (HP:0003348)2.11767279
84Nephrogenic diabetes insipidus (HP:0009806)2.11296203
85Medulloblastoma (HP:0002885)2.10832831
86Anencephaly (HP:0002323)2.10749871
87Hypoplasia of the fovea (HP:0007750)2.09291008
88Aplasia/Hypoplasia of the fovea (HP:0008060)2.09291008
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07619313
90Short 4th metacarpal (HP:0010044)2.07619313
91Neoplasm of the oral cavity (HP:0100649)2.06206887
92Abnormality of the ileum (HP:0001549)2.05786223
93Fair hair (HP:0002286)2.05184689
94Abdominal situs inversus (HP:0003363)2.02598207
95Abnormality of abdominal situs (HP:0011620)2.02598207
96Bile duct proliferation (HP:0001408)2.01789531
97Abnormal biliary tract physiology (HP:0012439)2.01789531
98Abnormality of the parietal bone (HP:0002696)2.00342101
99Furrowed tongue (HP:0000221)2.00128995
100Congenital sensorineural hearing impairment (HP:0008527)1.99877448
101Short middle phalanx of finger (HP:0005819)1.99382812
102Congenital, generalized hypertrichosis (HP:0004540)1.98045658
103Pendular nystagmus (HP:0012043)1.98045297
104Astigmatism (HP:0000483)1.97058438
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.95017440
106Decreased circulating renin level (HP:0003351)1.94825887
107Short tibia (HP:0005736)1.94639760
108* Sclerocornea (HP:0000647)1.93556466
109Clubbing of toes (HP:0100760)1.92836770
110Follicular hyperkeratosis (HP:0007502)1.92191583
111Decreased skull ossification (HP:0004331)1.91481186
112Small hand (HP:0200055)1.91440318
113Mixed hearing impairment (HP:0000410)1.90982526
114Lissencephaly (HP:0001339)1.90655256
115Muscle hypertrophy of the lower extremities (HP:0008968)1.90428646
116Adrenal hypoplasia (HP:0000835)1.90011044
117Sloping forehead (HP:0000340)1.88855810
118Abnormal rod and cone electroretinograms (HP:0008323)1.88779004
119Bifid tongue (HP:0010297)1.88507244
120Abnormality of chromosome stability (HP:0003220)1.87957056
121Postaxial hand polydactyly (HP:0001162)1.87259649
122Median cleft lip (HP:0000161)1.87062279
123Male pseudohermaphroditism (HP:0000037)1.86307610
124Broad metatarsal (HP:0001783)1.85120974
125Decreased central vision (HP:0007663)1.84820772
126Optic nerve hypoplasia (HP:0000609)1.84156747
127* Keratoconus (HP:0000563)1.83042699
128* Increased corneal curvature (HP:0100692)1.83042699
129Absent speech (HP:0001344)1.83021439
130Poor coordination (HP:0002370)1.81732729
131Oligohydramnios (HP:0001562)1.81345876
132Dandy-Walker malformation (HP:0001305)1.80569084
133Aplastic anemia (HP:0001915)1.80465777
134Epiphyseal dysplasia (HP:0002656)1.80100714
135Polyuria (HP:0000103)1.79729931
136Occipital encephalocele (HP:0002085)1.79728674
137Thyroid-stimulating hormone excess (HP:0002925)1.78819269
138Biconcave vertebral bodies (HP:0004586)1.78702037
139White forelock (HP:0002211)1.78489744
140Neoplasm of the adrenal cortex (HP:0100641)1.77618709
141Abnormal biliary tract morphology (HP:0012440)1.77525596
142Preaxial foot polydactyly (HP:0001841)1.77505315
143Abnormal respiratory motile cilium physiology (HP:0012261)1.76451480
144Abnormality of skull ossification (HP:0002703)1.76340859
145Oligodactyly (hands) (HP:0001180)1.75735665
146Supernumerary bones of the axial skeleton (HP:0009144)1.75179868
147Broad long bones (HP:0005622)1.75176554
148Duplication of thumb phalanx (HP:0009942)1.74927499
149Patchy hypopigmentation of hair (HP:0011365)1.74262563
150Tubulointerstitial nephritis (HP:0001970)1.73961083
151Chorioretinal atrophy (HP:0000533)1.73883637
152Deep philtrum (HP:0002002)1.73452693
153Ankle contracture (HP:0006466)1.73381689
154Abnormality of the ischium (HP:0003174)1.73379837
155Type I transferrin isoform profile (HP:0003642)1.71694714
156Mild short stature (HP:0003502)1.71642924
157Small intestinal stenosis (HP:0012848)1.71306050
158Duodenal stenosis (HP:0100867)1.71306050
159Hypotelorism (HP:0000601)1.70285158
160Absent septum pellucidum (HP:0001331)1.70022689
161Abnormal number of incisors (HP:0011064)1.67684379
162Abnormality of the phalanges of the hallux (HP:0010057)1.67596022
163Premature rupture of membranes (HP:0001788)1.65632335
164Absent frontal sinuses (HP:0002688)1.64660223
165Maternal diabetes (HP:0009800)1.63717976
166Abnormality of the renal collecting system (HP:0004742)1.63525013
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63137271
168Abnormality of the preputium (HP:0100587)1.63124753
169Bell-shaped thorax (HP:0001591)1.63044647
170Preaxial hand polydactyly (HP:0001177)1.62816212
171Missing ribs (HP:0000921)1.62809192
172Abnormality of the sella turcica (HP:0002679)1.62769842
173Abnormality of the incisor (HP:0000676)1.62522182
174Entropion (HP:0000621)1.61388168
175Anophthalmia (HP:0000528)1.61340924
176Flared metaphyses (HP:0003015)1.61166698
177Absent epiphyses (HP:0010577)1.61127884
178Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61127884
179Birth length less than 3rd percentile (HP:0003561)1.60873078
180Premature graying of hair (HP:0002216)1.60260677
181Fibular hypoplasia (HP:0003038)1.60102597
182Abnormality of the pubic bones (HP:0003172)1.59577488
183Limited hip movement (HP:0008800)1.59350787
184Embryonal renal neoplasm (HP:0011794)1.59043696
185Abnormality of molar (HP:0011077)1.58795981
186Abnormality of molar morphology (HP:0011070)1.58795981
187Aplasia/Hypoplasia of the fibula (HP:0006492)1.58778581
188Tracheomalacia (HP:0002779)1.58703522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.54568114
2MKNK13.65330816
3ZAK3.60160767
4CDC73.18577282
5BMPR1B3.01812667
6MKNK22.96591088
7NEK62.52532057
8ACVR1B2.48867347
9DDR22.48111651
10NUAK12.43501597
11WEE12.42980493
12MAP4K22.39972557
13WNK32.32286111
14TNIK2.21266834
15CDK82.18322018
16AKT32.10537797
17BRD42.07073852
18SRPK11.95970938
19GRK11.95931115
20STK161.95791088
21STK38L1.85697846
22CDK71.84491295
23EIF2AK11.84221184
24INSRR1.77008840
25MAP3K41.73681843
26MUSK1.72399684
27ATR1.66070706
28OXSR11.63403053
29ERBB31.55902686
30CDK121.53369821
31MAPK131.52168149
32TNK21.50982148
33TAOK31.50587927
34VRK11.50379239
35BUB11.47460398
36CLK11.44699891
37EIF2AK21.41847609
38TAOK21.38790912
39YES11.37807288
40PLK11.37643863
41STK391.32957285
42PLK31.30749200
43PNCK1.28279336
44PRPF4B1.26225786
45FLT31.25224817
46FGFR21.21528800
47TRIM281.21405663
48TTK1.18113044
49KIT1.17314057
50CHEK21.14546389
51AURKB1.14246482
52IRAK41.14033394
53TIE11.13725620
54PLK21.11862192
55PLK41.07902349
56TSSK61.07694698
57ADRBK11.07136032
58PIK3CG1.06262521
59LATS11.02537497
60PAK31.02491124
61RPS6KA41.00330544
62MST40.97424917
63CDK40.96190420
64BRSK20.96098813
65NME20.96010432
66TRPM70.95198493
67CCNB10.94188312
68MAPK70.92264315
69WNK40.89881929
70TAF10.89034988
71EPHA30.88885533
72MAP2K30.88119043
73PASK0.86071978
74TGFBR20.84483530
75OBSCN0.84447622
76RPS6KA50.83713674
77TGFBR10.81837115
78PTK2B0.80771619
79DYRK30.80174960
80MAP2K70.80056806
81CSNK1G10.78255208
82CSNK1G20.77947587
83BCR0.77858964
84CDK60.77139824
85PIK3CA0.75284140
86CDK90.74111144
87PIM10.74002637
88PRKCG0.73728369
89PRKG20.73537401
90PINK10.73254491
91DAPK20.73088992
92DYRK1A0.72659046
93RPS6KB20.72573580
94ATM0.71983628
95EPHA20.68691142
96VRK20.68294867
97TEC0.65956575
98EPHA40.65898839
99NEK10.62713374
100DYRK20.62153009
101CSNK1A1L0.62066185
102MAP3K60.62042716
103CAMKK20.60983493
104CHEK10.59820649
105TLK10.59150915
106NTRK30.58708838
107CDK20.57821023
108CSNK1G30.57803858
109MAP3K30.57126682
110CSNK2A10.55308684
111BMX0.54808945
112PIM20.54776904
113MAPK10.54127120
114CDK30.53606007
115MET0.53228089
116MAPKAPK50.52982182
117CAMK2A0.52768682
118PAK20.52686518
119CDK10.52484013
120FGFR10.51799432
121NLK0.51086049
122MOS0.50781537
123MELK0.50433497
124MARK10.50323512
125MAPK140.50244998
126AKT20.48760149
127SGK20.48071310
128STK30.47800180
129IRAK10.47595292
130NEK20.47524530
131AURKA0.45955445
132TXK0.45873958
133MAPK150.45068859
134CSF1R0.44559152
135CSNK1D0.43638945
136AKT10.42196312
137PKN10.41822269
138PAK40.41407775
139GSK3B0.39636984
140FER0.39111022
141PRKACB0.39027657
142SIK10.38946407
143CDK190.38827651
144ADRBK20.37298800
145STK240.37230302
146MATK0.37077616
147CAMK1G0.36577032
148STK110.36098156
149EIF2AK30.36049991
150PRKG10.35998090
151LATS20.35815008
152PRKCE0.35626853
153CASK0.35271679
154PHKG20.34031150
155PHKG10.34031150
156PRKACA0.32279814
157MAP3K70.30878360
158MYLK0.30782832
159GRK50.29819064

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.83549467
2Mismatch repair_Homo sapiens_hsa034303.74908841
3Homologous recombination_Homo sapiens_hsa034403.16580944
4Fanconi anemia pathway_Homo sapiens_hsa034602.95322259
5Non-homologous end-joining_Homo sapiens_hsa034502.90528008
6Nucleotide excision repair_Homo sapiens_hsa034202.70211418
7Base excision repair_Homo sapiens_hsa034102.69309335
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60519775
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41833232
10Butanoate metabolism_Homo sapiens_hsa006502.39973048
11RNA polymerase_Homo sapiens_hsa030202.38891473
12Phototransduction_Homo sapiens_hsa047442.33570863
13Cell cycle_Homo sapiens_hsa041102.31785947
14Spliceosome_Homo sapiens_hsa030402.16154571
15Ribosome_Homo sapiens_hsa030102.15995384
16RNA transport_Homo sapiens_hsa030132.15148039
17Propanoate metabolism_Homo sapiens_hsa006402.11007019
18Linoleic acid metabolism_Homo sapiens_hsa005912.06919093
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02236064
20Tryptophan metabolism_Homo sapiens_hsa003802.01816429
21Nitrogen metabolism_Homo sapiens_hsa009102.00969512
22One carbon pool by folate_Homo sapiens_hsa006701.96537568
23RNA degradation_Homo sapiens_hsa030181.90751433
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87113346
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84965045
26Basal cell carcinoma_Homo sapiens_hsa052171.84125493
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.78083148
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77663989
29Olfactory transduction_Homo sapiens_hsa047401.69935344
30Pyrimidine metabolism_Homo sapiens_hsa002401.68786560
31ECM-receptor interaction_Homo sapiens_hsa045121.65321944
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.62957268
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62248941
34Ether lipid metabolism_Homo sapiens_hsa005651.60556302
35p53 signaling pathway_Homo sapiens_hsa041151.59038732
36Taste transduction_Homo sapiens_hsa047421.52081050
37ABC transporters_Homo sapiens_hsa020101.50258967
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49266609
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47570117
40Basal transcription factors_Homo sapiens_hsa030221.37294775
41Purine metabolism_Homo sapiens_hsa002301.32783848
42Caffeine metabolism_Homo sapiens_hsa002321.32363476
43Hedgehog signaling pathway_Homo sapiens_hsa043401.31259914
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29671300
45mRNA surveillance pathway_Homo sapiens_hsa030151.28805920
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24593640
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22586268
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19995691
49TGF-beta signaling pathway_Homo sapiens_hsa043501.18712065
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.16081410
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13300787
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11480268
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11439364
54Oxidative phosphorylation_Homo sapiens_hsa001901.10824396
55beta-Alanine metabolism_Homo sapiens_hsa004101.09852726
56Systemic lupus erythematosus_Homo sapiens_hsa053221.08984675
57Protein digestion and absorption_Homo sapiens_hsa049741.08354301
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03008303
59Retinol metabolism_Homo sapiens_hsa008301.00341336
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98940389
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98472799
62MicroRNAs in cancer_Homo sapiens_hsa052060.97586446
63Peroxisome_Homo sapiens_hsa041460.97534795
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96926896
65Wnt signaling pathway_Homo sapiens_hsa043100.96784563
66Small cell lung cancer_Homo sapiens_hsa052220.96764042
67Serotonergic synapse_Homo sapiens_hsa047260.96738176
68Chemical carcinogenesis_Homo sapiens_hsa052040.96230704
69HTLV-I infection_Homo sapiens_hsa051660.92725579
70Malaria_Homo sapiens_hsa051440.92536325
71Melanoma_Homo sapiens_hsa052180.89597573
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89424062
73Hippo signaling pathway_Homo sapiens_hsa043900.89054209
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88618537
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88464473
76Circadian entrainment_Homo sapiens_hsa047130.88340955
77Regulation of autophagy_Homo sapiens_hsa041400.85663144
78N-Glycan biosynthesis_Homo sapiens_hsa005100.84377207
79GABAergic synapse_Homo sapiens_hsa047270.84164876
80Pathways in cancer_Homo sapiens_hsa052000.84013198
81Glutamatergic synapse_Homo sapiens_hsa047240.82409891
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82403154
83Parkinsons disease_Homo sapiens_hsa050120.80630156
84Dilated cardiomyopathy_Homo sapiens_hsa054140.80359882
85Glycerolipid metabolism_Homo sapiens_hsa005610.77477558
86Insulin secretion_Homo sapiens_hsa049110.76574791
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76218258
88Huntingtons disease_Homo sapiens_hsa050160.75899245
89Fatty acid degradation_Homo sapiens_hsa000710.75628871
90Salivary secretion_Homo sapiens_hsa049700.75220689
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.74907241
92Fatty acid biosynthesis_Homo sapiens_hsa000610.74591897
93Histidine metabolism_Homo sapiens_hsa003400.74387496
94Galactose metabolism_Homo sapiens_hsa000520.73229092
95Nicotine addiction_Homo sapiens_hsa050330.72283285
96Ovarian steroidogenesis_Homo sapiens_hsa049130.72205703
97Focal adhesion_Homo sapiens_hsa045100.71128234
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.71069581
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70761445
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70382441
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70145772
102Alcoholism_Homo sapiens_hsa050340.69877807
103Cardiac muscle contraction_Homo sapiens_hsa042600.69672990
104Calcium signaling pathway_Homo sapiens_hsa040200.69612702
105Herpes simplex infection_Homo sapiens_hsa051680.69114982
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67683148
107Thyroid cancer_Homo sapiens_hsa052160.67648956
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67641295
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67294373
110Dorso-ventral axis formation_Homo sapiens_hsa043200.65720291
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.64684741
112Proteoglycans in cancer_Homo sapiens_hsa052050.64275247
113Circadian rhythm_Homo sapiens_hsa047100.63068759
114Bladder cancer_Homo sapiens_hsa052190.60727425
115Colorectal cancer_Homo sapiens_hsa052100.60459362
116Arachidonic acid metabolism_Homo sapiens_hsa005900.60169845
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59430627
118Viral carcinogenesis_Homo sapiens_hsa052030.59050016
119Sulfur metabolism_Homo sapiens_hsa009200.57802505
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56793367
121Metabolic pathways_Homo sapiens_hsa011000.56788897
122Proteasome_Homo sapiens_hsa030500.56662668
123Adherens junction_Homo sapiens_hsa045200.56659601
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53642517
125Fructose and mannose metabolism_Homo sapiens_hsa000510.53295279
126Steroid biosynthesis_Homo sapiens_hsa001000.53094090
127Notch signaling pathway_Homo sapiens_hsa043300.52721925
128Fatty acid metabolism_Homo sapiens_hsa012120.49880934
129Sphingolipid metabolism_Homo sapiens_hsa006000.49069927
130Prostate cancer_Homo sapiens_hsa052150.48811330
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48149067
132Chronic myeloid leukemia_Homo sapiens_hsa052200.48088230
133Lysine degradation_Homo sapiens_hsa003100.47682527
134Hepatitis B_Homo sapiens_hsa051610.46421493
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45359350
136Alzheimers disease_Homo sapiens_hsa050100.45146564
137Sulfur relay system_Homo sapiens_hsa041220.44883288
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44645022
139Dopaminergic synapse_Homo sapiens_hsa047280.41926467
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40807833
141Acute myeloid leukemia_Homo sapiens_hsa052210.40739233
142Epstein-Barr virus infection_Homo sapiens_hsa051690.40217677
143Protein export_Homo sapiens_hsa030600.38610588
144cAMP signaling pathway_Homo sapiens_hsa040240.37412568
145Pancreatic secretion_Homo sapiens_hsa049720.36717463
146Fat digestion and absorption_Homo sapiens_hsa049750.35771399
147Hematopoietic cell lineage_Homo sapiens_hsa046400.34798815
148Long-term depression_Homo sapiens_hsa047300.34190243
149Pyruvate metabolism_Homo sapiens_hsa006200.33877940
150HIF-1 signaling pathway_Homo sapiens_hsa040660.33170104
151Melanogenesis_Homo sapiens_hsa049160.29907537
152Selenocompound metabolism_Homo sapiens_hsa004500.28699534
153Measles_Homo sapiens_hsa051620.28660862
154Morphine addiction_Homo sapiens_hsa050320.27140608
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.26160517
156Rap1 signaling pathway_Homo sapiens_hsa040150.25246795
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24699124
158Apoptosis_Homo sapiens_hsa042100.23844977
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.22890259
160ErbB signaling pathway_Homo sapiens_hsa040120.21431836
161Mineral absorption_Homo sapiens_hsa049780.21064983
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21003214
163Jak-STAT signaling pathway_Homo sapiens_hsa046300.20350045

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