PRDM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)5.07400125
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.06145241
3tryptophan catabolic process (GO:0006569)5.03439410
4indole-containing compound catabolic process (GO:0042436)5.03439410
5indolalkylamine catabolic process (GO:0046218)5.03439410
6kynurenine metabolic process (GO:0070189)4.64261722
7behavioral response to nicotine (GO:0035095)4.36515344
8tryptophan metabolic process (GO:0006568)4.26150535
9cilium or flagellum-dependent cell motility (GO:0001539)4.24809241
10photoreceptor cell maintenance (GO:0045494)4.21019734
11L-fucose catabolic process (GO:0042355)3.98942371
12fucose catabolic process (GO:0019317)3.98942371
13L-fucose metabolic process (GO:0042354)3.98942371
14detection of light stimulus involved in sensory perception (GO:0050962)3.94325981
15detection of light stimulus involved in visual perception (GO:0050908)3.94325981
16L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.87739683
17signal peptide processing (GO:0006465)3.77942791
18piRNA metabolic process (GO:0034587)3.76505631
19amine catabolic process (GO:0009310)3.62091635
20cellular biogenic amine catabolic process (GO:0042402)3.62091635
21protein K11-linked deubiquitination (GO:0035871)3.56451193
22tachykinin receptor signaling pathway (GO:0007217)3.55376729
23response to pheromone (GO:0019236)3.55154561
24neural tube formation (GO:0001841)3.53003481
25indole-containing compound metabolic process (GO:0042430)3.50235582
26cellular ketone body metabolic process (GO:0046950)3.43291680
27DNA methylation involved in gamete generation (GO:0043046)3.42570713
28amino acid salvage (GO:0043102)3.30387507
29L-methionine salvage (GO:0071267)3.30387507
30L-methionine biosynthetic process (GO:0071265)3.30387507
31behavioral response to ethanol (GO:0048149)3.29153444
32platelet dense granule organization (GO:0060155)3.25689390
33reflex (GO:0060004)3.25431515
34auditory receptor cell stereocilium organization (GO:0060088)3.16757087
35retinal cone cell development (GO:0046549)3.15993604
36ketone body metabolic process (GO:1902224)3.14617145
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14252506
38axoneme assembly (GO:0035082)3.14137257
39establishment of protein localization to Golgi (GO:0072600)3.04169231
40detection of mechanical stimulus involved in sensory perception (GO:0050974)3.03621679
41rhodopsin mediated signaling pathway (GO:0016056)3.03477753
42benzene-containing compound metabolic process (GO:0042537)3.01965049
43regulation of meiosis I (GO:0060631)2.96560152
44DNA double-strand break processing (GO:0000729)2.96329958
45dopamine transport (GO:0015872)2.94085002
46methionine biosynthetic process (GO:0009086)2.91404935
47negative regulation of mast cell activation (GO:0033004)2.91394763
48aromatic amino acid family metabolic process (GO:0009072)2.88981190
49aromatic amino acid family catabolic process (GO:0009074)2.88854901
50epithelial cilium movement (GO:0003351)2.86928674
51regulation of hippo signaling (GO:0035330)2.85370006
52regulation of rhodopsin mediated signaling pathway (GO:0022400)2.85073147
53gamma-aminobutyric acid transport (GO:0015812)2.84281039
54regulation of cilium movement (GO:0003352)2.83339853
55DNA deamination (GO:0045006)2.83328662
56protein prenylation (GO:0018342)2.82396902
57prenylation (GO:0097354)2.82396902
58inner ear receptor stereocilium organization (GO:0060122)2.82034324
59respiratory chain complex IV assembly (GO:0008535)2.81329001
60protein polyglutamylation (GO:0018095)2.78218981
61photoreceptor cell development (GO:0042461)2.76092966
62negative regulation of calcium ion transport into cytosol (GO:0010523)2.75474607
63reciprocal DNA recombination (GO:0035825)2.73812246
64reciprocal meiotic recombination (GO:0007131)2.73812246
65synapsis (GO:0007129)2.71826906
66thyroid hormone metabolic process (GO:0042403)2.69911507
67mannosylation (GO:0097502)2.68776145
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67977723
69organic cation transport (GO:0015695)2.67952920
70nonmotile primary cilium assembly (GO:0035058)2.67855606
71cellular response to sterol (GO:0036315)2.67639592
72male meiosis (GO:0007140)2.67520664
73multicellular organism reproduction (GO:0032504)2.66822343
74cilium morphogenesis (GO:0060271)2.66599421
75NAD biosynthetic process (GO:0009435)2.65491894
76protein-chromophore linkage (GO:0018298)2.64345885
77recombinational repair (GO:0000725)2.63601869
78serotonin metabolic process (GO:0042428)2.63364123
79double-strand break repair via homologous recombination (GO:0000724)2.62928171
80sulfation (GO:0051923)2.61813353
81cilium movement (GO:0003341)2.60357248
82primary amino compound metabolic process (GO:1901160)2.59888907
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58265832
84proline transport (GO:0015824)2.58114079
85protein localization to cilium (GO:0061512)2.57975709
86acrosome reaction (GO:0007340)2.57425906
87methionine metabolic process (GO:0006555)2.57419073
88cytochrome complex assembly (GO:0017004)2.54832969
89regulation of collateral sprouting (GO:0048670)2.53717376
90regulation of sarcomere organization (GO:0060297)2.53645040
91transmission of nerve impulse (GO:0019226)2.53018400
92male meiosis I (GO:0007141)2.52365818
93cilium organization (GO:0044782)2.51180597
94positive regulation of cAMP-mediated signaling (GO:0043950)2.48578240
95visual perception (GO:0007601)2.47445707
96transepithelial transport (GO:0070633)2.46810115
97regulation of action potential (GO:0098900)2.45854794
98eye photoreceptor cell development (GO:0042462)2.45846170
99cilium assembly (GO:0042384)2.45737646
100sensory perception of light stimulus (GO:0050953)2.45512818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.41771081
2GBX2_23144817_ChIP-Seq_PC3_Human3.39703131
3VDR_22108803_ChIP-Seq_LS180_Human3.29476247
4IGF1R_20145208_ChIP-Seq_DFB_Human3.22594416
5EZH2_22144423_ChIP-Seq_EOC_Human2.66835703
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59430313
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58185103
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46463830
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40857488
10TAF15_26573619_Chip-Seq_HEK293_Human2.39837507
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.39389665
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34709885
13P300_19829295_ChIP-Seq_ESCs_Human2.21242797
14FUS_26573619_Chip-Seq_HEK293_Human2.09652679
15ER_23166858_ChIP-Seq_MCF-7_Human2.06423733
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.04011212
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02756006
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99608932
19EWS_26573619_Chip-Seq_HEK293_Human1.91206543
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89549727
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82264851
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82248389
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78209973
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76715296
25* STAT3_23295773_ChIP-Seq_U87_Human1.75114676
26SMAD4_21799915_ChIP-Seq_A2780_Human1.67031432
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64857260
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64345846
29CBP_20019798_ChIP-Seq_JUKART_Human1.64345846
30TCF4_23295773_ChIP-Seq_U87_Human1.64282038
31IRF1_19129219_ChIP-ChIP_H3396_Human1.63008627
32BCAT_22108803_ChIP-Seq_LS180_Human1.61739862
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60331155
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55365826
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.54952846
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54189323
37TP53_22573176_ChIP-Seq_HFKS_Human1.52146195
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50024916
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49651162
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.46623522
41AR_25329375_ChIP-Seq_VCAP_Human1.46273129
42NANOG_19829295_ChIP-Seq_ESCs_Human1.45096913
43SOX2_19829295_ChIP-Seq_ESCs_Human1.45096913
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44049763
45TCF4_22108803_ChIP-Seq_LS180_Human1.43278326
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42973889
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42902702
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.39632365
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39630340
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.39088338
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38947848
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36898632
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36898632
54RUNX2_22187159_ChIP-Seq_PCA_Human1.34975864
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31381841
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31277078
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30276345
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.30077484
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.29721868
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.29709394
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26177423
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26148800
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23589107
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23061900
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22211951
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.22211951
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22138994
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22073820
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.20995746
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20878957
71AR_21572438_ChIP-Seq_LNCaP_Human1.20815982
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.19959367
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19063436
74CDX2_22108803_ChIP-Seq_LS180_Human1.18153499
75NCOR_22424771_ChIP-Seq_293T_Human1.17117333
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.16620969
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14301566
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11824388
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10856381
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10357149
81AR_20517297_ChIP-Seq_VCAP_Human1.07703287
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05647830
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.05422906
84REST_21632747_ChIP-Seq_MESCs_Mouse1.05077495
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04937621
86P53_22387025_ChIP-Seq_ESCs_Mouse1.04677677
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04051874
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04028281
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03765173
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.03663294
91* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02453271
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.01574619
93* HOXB7_26014856_ChIP-Seq_BT474_Human0.97519932
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.96526940
95* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95589910
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94514406
97P300_18555785_Chip-Seq_ESCs_Mouse0.94394883
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93514789
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93310250
100RNF2_27304074_Chip-Seq_NSC_Mouse0.93224736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.21176973
2MP0003195_calcinosis3.19682846
3MP0008877_abnormal_DNA_methylation3.05758354
4MP0000372_irregular_coat_pigmentation2.89267860
5MP0003646_muscle_fatigue2.72459672
6MP0000569_abnormal_digit_pigmentation2.71608684
7MP0005551_abnormal_eye_electrophysiolog2.71033538
8MP0004147_increased_porphyrin_level2.39688340
9MP0001968_abnormal_touch/_nociception2.36252318
10MP0002102_abnormal_ear_morphology2.33599825
11MP0002837_dystrophic_cardiac_calcinosis2.30908159
12MP0002736_abnormal_nociception_after2.27329720
13MP0005171_absent_coat_pigmentation2.26706116
14MP0002638_abnormal_pupillary_reflex2.24024453
15MP0001501_abnormal_sleep_pattern2.22364799
16MP0004043_abnormal_pH_regulation2.13472467
17MP0009046_muscle_twitch2.01597333
18MP0005253_abnormal_eye_physiology2.00917712
19MP0005174_abnormal_tail_pigmentation1.82261876
20MP0001986_abnormal_taste_sensitivity1.82060284
21MP0001984_abnormal_olfaction1.81262641
22MP0002138_abnormal_hepatobiliary_system1.76100302
23MP0000427_abnormal_hair_cycle1.75643331
24MP0006276_abnormal_autonomic_nervous1.75422921
25MP0008872_abnormal_physiological_respon1.71659942
26MP0009745_abnormal_behavioral_response1.69321621
27MP0005075_abnormal_melanosome_morpholog1.64995483
28MP0005646_abnormal_pituitary_gland1.55182420
29MP0001764_abnormal_homeostasis1.51482012
30MP0001529_abnormal_vocalization1.49684432
31MP0008057_abnormal_DNA_replication1.47102027
32MP0001486_abnormal_startle_reflex1.46160032
33MP0003950_abnormal_plasma_membrane1.44153197
34MP0003787_abnormal_imprinting1.42619865
35MP0001485_abnormal_pinna_reflex1.42253715
36MP0008875_abnormal_xenobiotic_pharmacok1.42118107
37MP0002876_abnormal_thyroid_physiology1.40264704
38MP0006072_abnormal_retinal_apoptosis1.39086016
39MP0005410_abnormal_fertilization1.35221812
40MP0002095_abnormal_skin_pigmentation1.34988844
41MP0002272_abnormal_nervous_system1.34870560
42MP0002938_white_spotting1.33500210
43MP0005670_abnormal_white_adipose1.33231082
44MP0005377_hearing/vestibular/ear_phenot1.31950741
45MP0003878_abnormal_ear_physiology1.31950741
46MP0002735_abnormal_chemical_nociception1.29216061
47MP0004142_abnormal_muscle_tone1.28876035
48MP0005167_abnormal_blood-brain_barrier1.24298844
49MP0010386_abnormal_urinary_bladder1.24241229
50MP0005645_abnormal_hypothalamus_physiol1.23648311
51MP0002160_abnormal_reproductive_system1.21925216
52MP0005310_abnormal_salivary_gland1.17023651
53MP0005084_abnormal_gallbladder_morpholo1.16375827
54MP0003011_delayed_dark_adaptation1.16007992
55MP0002928_abnormal_bile_duct1.12627244
56MP0005379_endocrine/exocrine_gland_phen1.11281919
57MP0006054_spinal_hemorrhage1.11233548
58MP0005386_behavior/neurological_phenoty1.09892924
59MP0004924_abnormal_behavior1.09892924
60MP0004381_abnormal_hair_follicle1.09730175
61MP0003718_maternal_effect1.09557825
62MP0005085_abnormal_gallbladder_physiolo1.09092042
63MP0000383_abnormal_hair_follicle1.07624006
64MP0002572_abnormal_emotion/affect_behav1.06721993
65MP0002163_abnormal_gland_morphology1.05176697
66MP0003252_abnormal_bile_duct1.05160704
67MP0002229_neurodegeneration1.04020956
68MP0008058_abnormal_DNA_repair1.03609476
69MP0003880_abnormal_central_pattern1.03480436
70MP0003698_abnormal_male_reproductive1.03093293
71MP0005389_reproductive_system_phenotype1.02113374
72MP0000015_abnormal_ear_pigmentation1.01724364
73MP0002064_seizures1.00551359
74MP0001970_abnormal_pain_threshold0.99385655
75MP0000230_abnormal_systemic_arterial0.98853036
76MP0004215_abnormal_myocardial_fiber0.96210562
77MP0001324_abnormal_eye_pigmentation0.96082497
78MP0006292_abnormal_olfactory_placode0.94241059
79MP0000631_abnormal_neuroendocrine_gland0.94038669
80MP0002067_abnormal_sensory_capabilities0.93874452
81MP0002653_abnormal_ependyma_morphology0.93484532
82MP0002557_abnormal_social/conspecific_i0.93244008
83MP0005083_abnormal_biliary_tract0.93048579
84MP0000371_diluted_coat_color0.92273012
85MP0005195_abnormal_posterior_eye0.89903752
86MP0001929_abnormal_gametogenesis0.89795768
87MP0000538_abnormal_urinary_bladder0.88291257
88MP0002254_reproductive_system_inflammat0.88213592
89MP0002733_abnormal_thermal_nociception0.88157701
90MP0004885_abnormal_endolymph0.88001273
91MP0005647_abnormal_sex_gland0.86806137
92MP0002210_abnormal_sex_determination0.82996571
93MP0004742_abnormal_vestibular_system0.82827718
94MP0005671_abnormal_response_to0.78000348
95MP0002752_abnormal_somatic_nervous0.76272644
96MP0005365_abnormal_bile_salt0.75107601
97MP0004133_heterotaxia0.74859600
98MP0004145_abnormal_muscle_electrophysio0.74626146
99MP0001963_abnormal_hearing_physiology0.72778840
100MP0003635_abnormal_synaptic_transmissio0.72659607

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.51503367
2True hermaphroditism (HP:0010459)3.93869891
3Pancreatic fibrosis (HP:0100732)3.91203974
4Congenital stationary night blindness (HP:0007642)3.88425512
5Molar tooth sign on MRI (HP:0002419)3.70820903
6Abnormality of midbrain morphology (HP:0002418)3.70820903
7Attenuation of retinal blood vessels (HP:0007843)3.52514363
8Abnormality of the renal cortex (HP:0011035)3.45329010
9Chronic hepatic failure (HP:0100626)3.32127918
10Nephronophthisis (HP:0000090)3.26232413
11Abolished electroretinogram (ERG) (HP:0000550)3.17189077
12Medial flaring of the eyebrow (HP:0010747)3.15544957
13Gaze-evoked nystagmus (HP:0000640)3.01268853
14Abnormality of the renal medulla (HP:0100957)3.00252737
15Genetic anticipation (HP:0003743)2.91475312
16Type II lissencephaly (HP:0007260)2.91320694
17Bony spicule pigmentary retinopathy (HP:0007737)2.85664912
18Hyperventilation (HP:0002883)2.84568101
19Congenital sensorineural hearing impairment (HP:0008527)2.82173732
20Cystic liver disease (HP:0006706)2.81777098
21Gait imbalance (HP:0002141)2.64538881
22Renal cortical cysts (HP:0000803)2.64181146
23Abnormal biliary tract physiology (HP:0012439)2.61252322
24Bile duct proliferation (HP:0001408)2.61252322
25Congenital primary aphakia (HP:0007707)2.60917763
26Febrile seizures (HP:0002373)2.60163602
27Abnormal drinking behavior (HP:0030082)2.58739450
28Polydipsia (HP:0001959)2.58739450
29Cerebellar dysplasia (HP:0007033)2.52872757
30Tubular atrophy (HP:0000092)2.49644074
31Progressive cerebellar ataxia (HP:0002073)2.49376487
32Nephrogenic diabetes insipidus (HP:0009806)2.46474852
33Clumsiness (HP:0002312)2.45078389
34Abnormal rod and cone electroretinograms (HP:0008323)2.43639999
35Progressive inability to walk (HP:0002505)2.40098442
36Inability to walk (HP:0002540)2.40063146
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33927496
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.30100343
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26080180
40Abnormality of alanine metabolism (HP:0010916)2.26080180
41Hyperalaninemia (HP:0003348)2.26080180
42Constricted visual fields (HP:0001133)2.25280265
43Decreased central vision (HP:0007663)2.25155286
44Absent speech (HP:0001344)2.24823857
45Pendular nystagmus (HP:0012043)2.24741672
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24324727
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.22920475
48Anencephaly (HP:0002323)2.17552731
49Sclerocornea (HP:0000647)2.15537841
50Retinitis pigmentosa (HP:0000510)2.15249388
51Congenital hepatic fibrosis (HP:0002612)2.14892860
52Genital tract atresia (HP:0001827)2.13133321
53Abnormality of the pons (HP:0007361)2.11246759
54Broad-based gait (HP:0002136)2.10434260
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.09694253
56Hypoplasia of the fovea (HP:0007750)2.09694253
57Protruding tongue (HP:0010808)2.08931425
58Lissencephaly (HP:0001339)2.06130559
59Vaginal atresia (HP:0000148)2.05279340
60Polyuria (HP:0000103)2.05074198
61Hypoplasia of the pons (HP:0012110)2.03004110
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02824173
63Increased neuronal autofluorescent lipopigment (HP:0002074)1.99765604
64Tubulointerstitial nephritis (HP:0001970)1.96567620
65Postaxial foot polydactyly (HP:0001830)1.96312020
66Dynein arm defect of respiratory motile cilia (HP:0012255)1.96163337
67Absent/shortened dynein arms (HP:0200106)1.96163337
68Central scotoma (HP:0000603)1.94289453
69Male pseudohermaphroditism (HP:0000037)1.93860768
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.93017447
71Fair hair (HP:0002286)1.90098979
72Dialeptic seizures (HP:0011146)1.89929855
73Stomach cancer (HP:0012126)1.87985141
74Increased corneal curvature (HP:0100692)1.87523479
75Keratoconus (HP:0000563)1.87523479
76Small hand (HP:0200055)1.87145754
77Abnormality of macular pigmentation (HP:0008002)1.86527650
78Focal seizures (HP:0007359)1.86490349
79Decreased circulating renin level (HP:0003351)1.85592188
80Abnormality of the labia minora (HP:0012880)1.85272439
81Furrowed tongue (HP:0000221)1.85175971
82Hyperglycinemia (HP:0002154)1.83731644
83Hypothermia (HP:0002045)1.82754251
84Astigmatism (HP:0000483)1.79784610
85Poor coordination (HP:0002370)1.78098750
86Tubulointerstitial abnormality (HP:0001969)1.77860068
87Supernumerary spleens (HP:0009799)1.75885032
88Hip dysplasia (HP:0001385)1.75603101
89Intestinal atresia (HP:0011100)1.73935255
90Sloping forehead (HP:0000340)1.73720809
91Generalized hypopigmentation of hair (HP:0011358)1.73696470
92Colon cancer (HP:0003003)1.73112958
93Large for gestational age (HP:0001520)1.71200485
94Short foot (HP:0001773)1.69058369
95Severe muscular hypotonia (HP:0006829)1.67873798
96Abnormality of the fovea (HP:0000493)1.67491008
97Polyphagia (HP:0002591)1.67143071
98Photophobia (HP:0000613)1.66102208
993-Methylglutaconic aciduria (HP:0003535)1.65654033
100Abnormal ciliary motility (HP:0012262)1.65178860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.75963600
2ADRBK23.19471480
3WNK33.11055230
4MAP4K22.71219545
5BMPR1B2.71163888
6ZAK2.54793700
7PINK12.41853285
8ACVR1B2.41642390
9GRK12.19256240
10STK38L2.13349274
11NUAK12.07615003
12MAP3K41.80850063
13TAOK31.79603952
14TXK1.74890024
15OXSR11.73942695
16INSRR1.65073161
17MAPK131.64854177
18WNK41.61764669
19STK391.55217509
20CASK1.48864575
21TRIM281.46698389
22LATS11.28343876
23PIK3CG1.21408569
24MKNK21.12963236
25MUSK1.12834988
26EIF2AK31.12782813
27MAP2K71.09785103
28BCKDK1.05752055
29BCR1.03445585
30ADRBK11.02195691
31DAPK20.94678052
32PDK20.94618703
33TNIK0.94021654
34PLK20.91397393
35STK30.91262151
36TEC0.90048290
37PAK30.89316564
38TGFBR10.88433811
39PRKCG0.86281654
40NLK0.82282106
41PRKCE0.81698209
42MATK0.79541500
43DYRK20.78311605
44TNK20.77421804
45KIT0.74782325
46GRK70.70031403
47PLK40.67337360
48CSNK1G10.66679636
49MARK10.65522101
50NTRK30.65137458
51BRSK20.64738579
52PIK3CA0.64527912
53PRKCQ0.64213519
54AKT30.64036416
55MKNK10.63888778
56MAPKAPK30.63568377
57EPHA40.63359234
58CSNK1A1L0.62339262
59MARK30.59213663
60FER0.59130608
61PTK2B0.57519422
62VRK10.57113175
63TLK10.57091409
64CSNK1G20.55735793
65MST40.55500433
66CAMKK20.55115537
67IKBKB0.54488923
68CCNB10.54264063
69IRAK10.53467559
70CSNK1G30.52446117
71WEE10.49502785
72TIE10.48960726
73PKN10.48255959
74OBSCN0.48133562
75DYRK1A0.46089770
76PRKAA20.45830496
77NME10.45290955
78FLT30.45260487
79FGFR20.44602614
80CAMK2A0.44388717
81CDK190.44013744
82PLK30.42934500
83MAP2K60.42551453
84STK380.40336651
85PRKACA0.39378049
86ITK0.39316133
87PHKG20.37251716
88PHKG10.37251716
89CSNK1A10.35861358
90MAP3K70.34795370
91SYK0.34475934
92CSNK1D0.34349914
93SIK30.33870735
94CHUK0.33352328
95CHEK20.33272188
96CAMK10.33045147
97RPS6KA50.32206455
98MAPKAPK50.32120244
99ERBB30.31780973
100NEK20.31568154

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.32066470
2Butanoate metabolism_Homo sapiens_hsa006502.93397775
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.73605962
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54590333
5Linoleic acid metabolism_Homo sapiens_hsa005912.51074733
6Tryptophan metabolism_Homo sapiens_hsa003802.29580949
7Nitrogen metabolism_Homo sapiens_hsa009102.26869010
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25178794
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14633754
10Nicotine addiction_Homo sapiens_hsa050332.12429114
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11916034
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.11159305
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10488647
14ABC transporters_Homo sapiens_hsa020101.92288390
15Selenocompound metabolism_Homo sapiens_hsa004501.90618850
16Homologous recombination_Homo sapiens_hsa034401.88864641
17Propanoate metabolism_Homo sapiens_hsa006401.84823250
18Ether lipid metabolism_Homo sapiens_hsa005651.84043571
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80450565
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73685589
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72287995
22Olfactory transduction_Homo sapiens_hsa047401.68845612
23Fanconi anemia pathway_Homo sapiens_hsa034601.66458013
24Basal transcription factors_Homo sapiens_hsa030221.54205972
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.53556287
26Taste transduction_Homo sapiens_hsa047421.51656607
27Caffeine metabolism_Homo sapiens_hsa002321.40874837
28Morphine addiction_Homo sapiens_hsa050321.35404689
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33811789
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32482152
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31852932
32RNA polymerase_Homo sapiens_hsa030201.30480319
33beta-Alanine metabolism_Homo sapiens_hsa004101.25502995
34Non-homologous end-joining_Homo sapiens_hsa034501.22960602
35Retinol metabolism_Homo sapiens_hsa008301.20745249
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14781393
37Arachidonic acid metabolism_Homo sapiens_hsa005901.13326097
38Chemical carcinogenesis_Homo sapiens_hsa052041.11994942
39Peroxisome_Homo sapiens_hsa041461.10837177
40Protein export_Homo sapiens_hsa030601.06116374
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05416195
42One carbon pool by folate_Homo sapiens_hsa006701.03283301
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97395860
44Salivary secretion_Homo sapiens_hsa049700.94786122
45Sphingolipid metabolism_Homo sapiens_hsa006000.93795852
46Serotonergic synapse_Homo sapiens_hsa047260.93303511
47GABAergic synapse_Homo sapiens_hsa047270.92599690
48Circadian entrainment_Homo sapiens_hsa047130.91820095
49Ovarian steroidogenesis_Homo sapiens_hsa049130.90793347
50Regulation of autophagy_Homo sapiens_hsa041400.89298090
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88990953
52Collecting duct acid secretion_Homo sapiens_hsa049660.88985621
53Glycerolipid metabolism_Homo sapiens_hsa005610.87432301
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.86280474
55Glutamatergic synapse_Homo sapiens_hsa047240.85397509
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85225530
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84120266
58Calcium signaling pathway_Homo sapiens_hsa040200.83019762
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80465199
60Sulfur relay system_Homo sapiens_hsa041220.79790857
61Purine metabolism_Homo sapiens_hsa002300.77176894
62RNA degradation_Homo sapiens_hsa030180.77034523
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.75989292
64Oxidative phosphorylation_Homo sapiens_hsa001900.74827715
65Fat digestion and absorption_Homo sapiens_hsa049750.73920403
66Histidine metabolism_Homo sapiens_hsa003400.72776946
67Fatty acid degradation_Homo sapiens_hsa000710.69612210
68Primary immunodeficiency_Homo sapiens_hsa053400.68838815
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.68045393
70Circadian rhythm_Homo sapiens_hsa047100.66070098
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65835025
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65747542
73Metabolic pathways_Homo sapiens_hsa011000.63929154
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56814995
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56779387
76Sulfur metabolism_Homo sapiens_hsa009200.55783851
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55653223
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55282373
79Graft-versus-host disease_Homo sapiens_hsa053320.55058041
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54854094
81Vitamin digestion and absorption_Homo sapiens_hsa049770.54689437
82Fatty acid metabolism_Homo sapiens_hsa012120.52308246
83Insulin secretion_Homo sapiens_hsa049110.51088809
84Lysine degradation_Homo sapiens_hsa003100.50163991
85Pyrimidine metabolism_Homo sapiens_hsa002400.48491157
86Mineral absorption_Homo sapiens_hsa049780.47737265
87Fatty acid biosynthesis_Homo sapiens_hsa000610.47691085
88Dorso-ventral axis formation_Homo sapiens_hsa043200.46087322
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44537374
90Long-term depression_Homo sapiens_hsa047300.42758557
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.41382491
92Rheumatoid arthritis_Homo sapiens_hsa053230.40956164
93Steroid biosynthesis_Homo sapiens_hsa001000.38319600
94Asthma_Homo sapiens_hsa053100.38168148
95Parkinsons disease_Homo sapiens_hsa050120.35470430
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.35057711
97Huntingtons disease_Homo sapiens_hsa050160.34303876
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.30621510
99N-Glycan biosynthesis_Homo sapiens_hsa005100.29202922
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27138354

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