PRDM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.60679359
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.48315164
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26677975
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23682554
5vocalization behavior (GO:0071625)5.23211707
6neuron cell-cell adhesion (GO:0007158)5.15874976
7locomotory exploration behavior (GO:0035641)5.03703756
8protein localization to synapse (GO:0035418)5.01746600
9regulation of glutamate receptor signaling pathway (GO:1900449)4.85647807
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.79722252
11exploration behavior (GO:0035640)4.68889740
12glutamate receptor signaling pathway (GO:0007215)4.53162881
13presynaptic membrane assembly (GO:0097105)4.50657714
14synaptic vesicle maturation (GO:0016188)4.43322900
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40037350
16synaptic transmission, glutamatergic (GO:0035249)4.34670329
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.31596998
18presynaptic membrane organization (GO:0097090)4.30700934
19postsynaptic membrane organization (GO:0001941)4.29611783
20neurotransmitter-gated ion channel clustering (GO:0072578)4.28287890
21glutamate secretion (GO:0014047)4.23563468
22synaptic vesicle exocytosis (GO:0016079)4.13597166
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.12313468
24regulation of synaptic vesicle exocytosis (GO:2000300)4.04794296
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.01618927
26dendritic spine morphogenesis (GO:0060997)3.93813486
27neuron recognition (GO:0008038)3.89971894
28negative regulation of erythrocyte differentiation (GO:0045647)3.87954315
29neuron-neuron synaptic transmission (GO:0007270)3.86960756
30regulation of vitamin D biosynthetic process (GO:0060556)3.82385572
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.75728721
32regulation of neuronal synaptic plasticity (GO:0048168)3.74905878
33long-term memory (GO:0007616)3.74807219
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.74525606
35axonal fasciculation (GO:0007413)3.69305694
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67493614
37regulation of synaptic vesicle transport (GO:1902803)3.65845750
38positive regulation of synapse maturation (GO:0090129)3.64540100
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62200032
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.59543266
41neuronal action potential propagation (GO:0019227)3.59512134
42regulation of postsynaptic membrane potential (GO:0060078)3.58043611
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57397542
44* central nervous system projection neuron axonogenesis (GO:0021952)3.56016681
45positive regulation of membrane potential (GO:0045838)3.54092679
46cerebellar granule cell differentiation (GO:0021707)3.46672488
47startle response (GO:0001964)3.40219782
48response to muramyl dipeptide (GO:0032495)3.35544875
49response to peptidoglycan (GO:0032494)3.35082561
50cerebral cortex radially oriented cell migration (GO:0021799)3.34790394
51regulation of synapse maturation (GO:0090128)3.34002568
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.30110625
53dendritic spine organization (GO:0097061)3.27309235
54dendrite morphogenesis (GO:0048813)3.23202210
55regulation of T-helper 2 cell differentiation (GO:0045628)3.18397584
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17898416
57positive regulation of neurotransmitter secretion (GO:0001956)3.16224957
58regulation of neurotransmitter secretion (GO:0046928)3.15496328
59neurotransmitter secretion (GO:0007269)3.13450456
60synaptic vesicle endocytosis (GO:0048488)3.13261137
61regulation of synaptic plasticity (GO:0048167)3.13103660
62response to histamine (GO:0034776)3.09584182
63transmission of nerve impulse (GO:0019226)3.08542667
64behavioral fear response (GO:0001662)3.08353933
65behavioral defense response (GO:0002209)3.08353933
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05845153
67long-term synaptic potentiation (GO:0060291)3.04876023
68positive regulation of gamma-delta T cell activation (GO:0046645)3.04290060
69layer formation in cerebral cortex (GO:0021819)3.04211638
70membrane depolarization (GO:0051899)3.04142999
71positive regulation of synapse assembly (GO:0051965)3.02551264
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01998755
73neuronal ion channel clustering (GO:0045161)2.99853071
74regulation of vesicle fusion (GO:0031338)2.99587906
75synapse assembly (GO:0007416)2.98803757
76negative regulation of cell killing (GO:0031342)2.98518160
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98518160
78germinal center formation (GO:0002467)2.98029032
79membrane hyperpolarization (GO:0060081)2.98000269
80auditory behavior (GO:0031223)2.97687866
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97681540
82innervation (GO:0060384)2.95542793
83righting reflex (GO:0060013)2.94833072
84response to auditory stimulus (GO:0010996)2.93682956
85gamma-aminobutyric acid transport (GO:0015812)2.91435603
86cellular potassium ion homeostasis (GO:0030007)2.91325326
87regulation of dendritic spine morphogenesis (GO:0061001)2.90885411
88learning (GO:0007612)2.90563005
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89189544
90* central nervous system neuron axonogenesis (GO:0021955)2.88847614
91fear response (GO:0042596)2.88801469
92cerebellar Purkinje cell differentiation (GO:0021702)2.88652229
93L-amino acid import (GO:0043092)2.87200710
94positive regulation of dendritic spine development (GO:0060999)2.86381975
95negative regulation of interleukin-12 production (GO:0032695)2.85941983
96regulation of ARF protein signal transduction (GO:0032012)2.84950357
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83800705
98membrane depolarization during action potential (GO:0086010)2.82866267
99protein localization to endosome (GO:0036010)2.81024129
100dendrite development (GO:0016358)2.80653494
101regulation of T-helper 1 cell differentiation (GO:0045625)2.80577564
102regulation of respiratory system process (GO:0044065)2.78894868
103negative regulation of type 2 immune response (GO:0002829)2.78132564
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76739167
105regulation of neurotransmitter transport (GO:0051588)2.76476337
106neurotransmitter transport (GO:0006836)2.75900765
107macrophage activation involved in immune response (GO:0002281)2.75884548
108regulation of synapse structural plasticity (GO:0051823)2.75476574
109regulation of synaptic transmission, GABAergic (GO:0032228)2.74755373
110regulation of dendritic spine development (GO:0060998)2.74602789
111mechanosensory behavior (GO:0007638)2.74051656
112regulation of synapse assembly (GO:0051963)2.74010302
113positive regulation of neurotransmitter transport (GO:0051590)2.73990969
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.73907664
115regulation of vitamin metabolic process (GO:0030656)2.73844651
116regulation of synaptic transmission (GO:0050804)2.69793406
117adult walking behavior (GO:0007628)2.66820439
118synaptic transmission (GO:0007268)2.66235319
119proline transport (GO:0015824)2.64179498
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63874315
121response to nerve growth factor (GO:1990089)2.63614566
122cellular response to nerve growth factor stimulus (GO:1990090)2.63614566
123signal complex assembly (GO:0007172)2.63589859
124regulation of type 2 immune response (GO:0002828)2.61832685
125urinary tract smooth muscle contraction (GO:0014848)2.58137396
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.50815223
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.50815223
128modulation by symbiont of host immune response (GO:0052553)2.50815223
129positive regulation by symbiont of host defense response (GO:0052509)2.50815223
130modulation by symbiont of host defense response (GO:0052031)2.50815223
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.50815223
132activation of MAPKKK activity (GO:0000185)2.50204658
133leukocyte aggregation (GO:0070486)2.49043692
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40993096
135tolerance induction (GO:0002507)2.39755968
136regulation of chemokine biosynthetic process (GO:0045073)2.35446960
137negative regulation of T cell mediated immunity (GO:0002710)2.34450275
138positive regulation of type 2 immune response (GO:0002830)2.33392893
139stress fiber assembly (GO:0043149)2.31486481
140regulation of NFAT protein import into nucleus (GO:0051532)2.31395890
141positive regulation of Rap GTPase activity (GO:0032854)2.31139889
142cortical actin cytoskeleton organization (GO:0030866)2.28463563
143negative regulation of dendrite morphogenesis (GO:0050774)2.28290661
144defense response to protozoan (GO:0042832)2.28132424
145NIK/NF-kappaB signaling (GO:0038061)2.27085755
146positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.26367032
147neuromuscular process controlling balance (GO:0050885)2.25324695
148response to manganese ion (GO:0010042)2.24931932
149positive regulation of T-helper cell differentiation (GO:0045624)2.22478223
150mature B cell differentiation involved in immune response (GO:0002313)2.22110016
151response to protozoan (GO:0001562)2.19704663
152positive regulation of chemokine biosynthetic process (GO:0045080)2.19517902
153regulation of leukocyte degranulation (GO:0043300)2.18855417
154positive regulation of natural killer cell differentiation (GO:0032825)2.18317418
155regulation of regulated secretory pathway (GO:1903305)2.18297604
156neuron remodeling (GO:0016322)2.16348892
157nerve growth factor signaling pathway (GO:0038180)2.16173323
158regulation of Rap GTPase activity (GO:0032317)2.15102269
159regulation of fever generation (GO:0031620)2.14796823
160response to type I interferon (GO:0034340)2.14723263
161regulation of T-helper cell differentiation (GO:0045622)2.14623089
162negative regulation of cytokine production involved in immune response (GO:0002719)2.14577925
163type I interferon signaling pathway (GO:0060337)2.14241671
164cellular response to type I interferon (GO:0071357)2.14241671
165neutrophil mediated immunity (GO:0002446)2.13414062
166positive regulation of heat generation (GO:0031652)2.12828258
167cell migration in hindbrain (GO:0021535)2.12572597
168substrate-dependent cell migration (GO:0006929)2.11186152
169regulation of macrophage cytokine production (GO:0010935)2.11180606
170positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.09917821
171cellular extravasation (GO:0045123)2.08204681
172negative regulation of toll-like receptor signaling pathway (GO:0034122)2.06038465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99433856
2GBX2_23144817_ChIP-Seq_PC3_Human3.85210217
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01040852
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87010224
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73246409
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60786817
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.59964330
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.58290928
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51020441
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.50143316
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48621157
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47461903
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47461903
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43135015
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42447584
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.40070284
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39548033
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38285607
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28556506
20REST_21632747_ChIP-Seq_MESCs_Mouse2.27886890
21VDR_21846776_ChIP-Seq_THP-1_Human2.25779835
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23384882
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21402823
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20122864
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19653199
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18101964
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17466576
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11703714
29KDM2B_26808549_Chip-Seq_DND41_Human2.11038603
30VDR_24763502_ChIP-Seq_THP-1_Human2.10533040
31IRF8_22096565_ChIP-ChIP_GC-B_Human2.08866626
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08575950
33DROSHA_22980978_ChIP-Seq_HELA_Human2.06461411
34TCF7_22412390_ChIP-Seq_EML_Mouse1.95801504
35KDM2B_26808549_Chip-Seq_K562_Human1.94716133
36* CBX2_27304074_Chip-Seq_ESCs_Mouse1.93594130
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92241983
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85436740
39* KDM2B_26808549_Chip-Seq_JURKAT_Human1.83280746
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83233279
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82136788
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79904289
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78071219
44TAF15_26573619_Chip-Seq_HEK293_Human1.77497564
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77335663
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75663592
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75283136
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.72952806
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71919200
50VDR_24787735_ChIP-Seq_THP-1_Human1.71409422
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70628559
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69653332
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69557546
54* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69270466
55P300_19829295_ChIP-Seq_ESCs_Human1.67987186
56SMAD4_21799915_ChIP-Seq_A2780_Human1.67601626
57* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64389913
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64117403
59RUNX_20019798_ChIP-Seq_JUKART_Human1.63074773
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62865581
61* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62534666
62AR_21572438_ChIP-Seq_LNCaP_Human1.59988533
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.59909037
64* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59723520
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.59419730
66SCL_19346495_ChIP-Seq_HPC-7_Human1.59078425
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58807578
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55226947
69* RNF2_27304074_Chip-Seq_NSC_Mouse1.51859995
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51303771
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.49048773
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47926014
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47804172
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.46998468
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46908353
76* LXR_22292898_ChIP-Seq_THP-1_Human1.46185831
77MYC_22102868_ChIP-Seq_BL_Human1.41711012
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40136483
79IGF1R_20145208_ChIP-Seq_DFB_Human1.40100722
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38117616
81VDR_22108803_ChIP-Seq_LS180_Human1.37704536
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37294481
83SPI1_23127762_ChIP-Seq_K562_Human1.37037471
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36169660
85FUS_26573619_Chip-Seq_HEK293_Human1.36039653
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.33523159
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33421635
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32013040
89AR_25329375_ChIP-Seq_VCAP_Human1.31941475
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.31619782
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31408882
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31071354
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31071169
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28513509
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28055908
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27526389
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.27246427
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.26598044
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26468330
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24732379
101ZNF274_21170338_ChIP-Seq_K562_Hela1.23927480
102MAF_26560356_Chip-Seq_TH1_Human1.23522748
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23365341
104STAT3_23295773_ChIP-Seq_U87_Human1.23272478
105* RING1B_27294783_Chip-Seq_ESCs_Mouse1.23227351
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22665268
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22174748
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21626127
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21626127
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.21571026
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21418252
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21405888
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20077968
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17761437
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.16948130
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15975441
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15817667
118TCF4_23295773_ChIP-Seq_U87_Human1.15787717
119ER_23166858_ChIP-Seq_MCF-7_Human1.15750675
120* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15578854
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14312199
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14218476
123UTX_26944678_Chip-Seq_JUKART_Human1.13739756
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13356169
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.12413601
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12344119
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12336507
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11227680
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10293988
130ERG_21242973_ChIP-ChIP_JURKAT_Human1.09827219
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09233945
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.09160370
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08913785
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.07521597
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.06858265
136RUNX2_22187159_ChIP-Seq_PCA_Human1.05997202
137GATA2_21666600_ChIP-Seq_HMVEC_Human1.05962574
138STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05484284
139TP53_18474530_ChIP-ChIP_U2OS_Human1.05181913
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05059291
141FLI1_27457419_Chip-Seq_LIVER_Mouse1.04982056
142P53_22387025_ChIP-Seq_ESCs_Mouse1.04878917
143PRDM14_20953172_ChIP-Seq_ESCs_Human1.04877533
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04843782
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04486887
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04142174
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04123643
148ESR2_21235772_ChIP-Seq_MCF-7_Human1.03178195
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01133659
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00474732
151SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00391559
152AR_19668381_ChIP-Seq_PC3_Human1.00153877
153YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99510347
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99124304
155KDM2B_26808549_Chip-Seq_REH_Human0.98279509
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98179522
157SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97850872
158TP53_16413492_ChIP-PET_HCT116_Human0.97579443
159AHR_22903824_ChIP-Seq_MCF-7_Human0.96943259
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96700002
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96262354
162MAF_26560356_Chip-Seq_TH2_Human0.95963279
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95769002
164RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95731474
165* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94664069
166NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94492705
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94178598
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94122349
169* JUN_21703547_ChIP-Seq_K562_Human0.93487843
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88533021
171IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87969017
172* TP53_20018659_ChIP-ChIP_R1E_Mouse0.87589685
173CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87561945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.82322852
2MP0003880_abnormal_central_pattern4.82633069
3MP0003303_peritoneal_inflammation4.73280047
4MP0003635_abnormal_synaptic_transmissio3.60596947
5MP0003436_decreased_susceptibility_to3.36479990
6MP0005423_abnormal_somatic_nervous3.29477491
7MP0004270_analgesia3.14621694
8MP0001968_abnormal_touch/_nociception3.06606128
9MP0009745_abnormal_behavioral_response3.05639466
10MP0004510_myositis3.03325993
11MP0002063_abnormal_learning/memory/cond2.91318467
12MP0001486_abnormal_startle_reflex2.74307395
13MP0002735_abnormal_chemical_nociception2.72960336
14MP0002064_seizures2.72547569
15MP0002572_abnormal_emotion/affect_behav2.66178718
16MP0002734_abnormal_mechanical_nocicepti2.51642635
17MP0009046_muscle_twitch2.50825801
18MP0002736_abnormal_nociception_after2.49533172
19MP0009278_abnormal_bone_marrow2.40799820
20MP0003724_increased_susceptibility_to2.39389666
21MP0006292_abnormal_olfactory_placode2.33561521
22MP0002272_abnormal_nervous_system2.31744814
23MP0000778_abnormal_nervous_system2.23858080
24MP0001440_abnormal_grooming_behavior2.13244970
25MP0003300_gastrointestinal_ulcer2.05126612
26MP0005000_abnormal_immune_tolerance2.02915022
27MP0002067_abnormal_sensory_capabilities2.00554823
28MP0005551_abnormal_eye_electrophysiolog1.98605929
29MP0006276_abnormal_autonomic_nervous1.98587162
30MP0001835_abnormal_antigen_presentation1.97349957
31MP0003172_abnormal_lysosome_physiology1.92980920
32MP0003075_altered_response_to1.91136254
33MP0002184_abnormal_innervation1.90209368
34MP0001188_hyperpigmentation1.89533047
35MP0002419_abnormal_innate_immunity1.86441815
36MP0002148_abnormal_hypersensitivity_rea1.86237663
37MP0004947_skin_inflammation1.83206633
38MP0006082_CNS_inflammation1.80265738
39MP0001984_abnormal_olfaction1.79081469
40MP0003787_abnormal_imprinting1.78280431
41MP0001970_abnormal_pain_threshold1.76997173
42MP0002733_abnormal_thermal_nociception1.72779220
43MP0005646_abnormal_pituitary_gland1.71596548
44MP0002557_abnormal_social/conspecific_i1.71324912
45MP0003091_abnormal_cell_migration1.67592169
46MP0001533_abnormal_skeleton_physiology1.66364677
47MP0004742_abnormal_vestibular_system1.66361952
48MP0005025_abnormal_response_to1.65202473
49MP0008569_lethality_at_weaning1.64748366
50MP0005645_abnormal_hypothalamus_physiol1.64352981
51MP0000604_amyloidosis1.61790947
52MP0005171_absent_coat_pigmentation1.60816379
53MP0001501_abnormal_sleep_pattern1.60395588
54MP0003879_abnormal_hair_cell1.56932623
55MP0009785_altered_susceptibility_to1.54080972
56MP0002882_abnormal_neuron_morphology1.52691734
57MP0003122_maternal_imprinting1.49556961
58MP0002723_abnormal_immune_serum1.48893362
59MP0004808_abnormal_hematopoietic_stem1.47655589
60MP0004885_abnormal_endolymph1.47453193
61MP0003690_abnormal_glial_cell1.45868463
62MP0001800_abnormal_humoral_immune1.45393991
63MP0001790_abnormal_immune_system1.44919873
64MP0005387_immune_system_phenotype1.44919873
65MP0004924_abnormal_behavior1.44346878
66MP0005386_behavior/neurological_phenoty1.44346878
67MP0004811_abnormal_neuron_physiology1.43135884
68MP0001905_abnormal_dopamine_level1.40726202
69MP0005397_hematopoietic_system_phenotyp1.39469650
70MP0001545_abnormal_hematopoietic_system1.39469650
71MP0001502_abnormal_circadian_rhythm1.39378488
72MP0000955_abnormal_spinal_cord1.38360808
73MP0002420_abnormal_adaptive_immunity1.37005258
74MP0002452_abnormal_antigen_presenting1.36642671
75MP0009764_decreased_sensitivity_to1.36417284
76MP0003279_aneurysm1.36111209
77MP0001819_abnormal_immune_cell1.34996366
78MP0005058_abnormal_lysosome_morphology1.32686774
79MP0002998_abnormal_bone_remodeling1.31590353
80MP0009780_abnormal_chondrocyte_physiolo1.26793179
81MP0000569_abnormal_digit_pigmentation1.26344110
82MP0004142_abnormal_muscle_tone1.25632942
83MP0002066_abnormal_motor_capabilities/c1.25565441
84MP0002102_abnormal_ear_morphology1.24939226
85MP0003705_abnormal_hypodermis_morpholog1.23296010
86MP0005253_abnormal_eye_physiology1.22844146
87MP0002638_abnormal_pupillary_reflex1.22657357
88MP0005464_abnormal_platelet_physiology1.21071005
89MP0002332_abnormal_exercise_endurance1.19227698
90MP0001963_abnormal_hearing_physiology1.18448147
91MP0002752_abnormal_somatic_nervous1.17361017
92MP0003763_abnormal_thymus_physiology1.15046178
93MP0005410_abnormal_fertilization1.14916308
94MP0008874_decreased_physiological_sensi1.14111400
95MP0005166_decreased_susceptibility_to1.12592826
96MP0001529_abnormal_vocalization1.12030378
97MP0003448_altered_tumor_morphology1.10995225
98MP0002405_respiratory_system_inflammati1.10374475
99MP0004858_abnormal_nervous_system1.08486165
100MP0000026_abnormal_inner_ear1.08142673
101MP0005409_darkened_coat_color1.08119096
102MP0006072_abnormal_retinal_apoptosis1.07681733
103MP0002152_abnormal_brain_morphology1.07614471
104MP0003633_abnormal_nervous_system1.06924917
105MP0002822_catalepsy1.05899179
106MP0010386_abnormal_urinary_bladder1.05406389
107MP0001958_emphysema1.05219266
108MP0002229_neurodegeneration1.03954036
109MP0000716_abnormal_immune_system1.03275421
110MP0000631_abnormal_neuroendocrine_gland1.02604485
111MP0005076_abnormal_cell_differentiation1.02032798
112MP0010155_abnormal_intestine_physiology1.01642097
113MP0003828_pulmonary_edema1.01135648
114MP0002398_abnormal_bone_marrow1.00581148
115MP0005164_abnormal_response_to1.00378921
116MP0005671_abnormal_response_to0.99025929
117MP0003329_amyloid_beta_deposits0.97800025
118MP0001986_abnormal_taste_sensitivity0.95524904
119MP0005390_skeleton_phenotype0.95494273
120MP0005623_abnormal_meninges_morphology0.94855346
121MP0000858_altered_metastatic_potential0.94627435
122MP0003631_nervous_system_phenotype0.93979170
123MP0001542_abnormal_bone_strength0.92314018
124MP0003136_yellow_coat_color0.92185665
125MP0005535_abnormal_body_temperature0.92024442
126MP0002876_abnormal_thyroid_physiology0.91847358
127MP0000685_abnormal_immune_system0.89975726
128MP0001485_abnormal_pinna_reflex0.89902927
129MP0001851_eye_inflammation0.89793126
130MP0003938_abnormal_ear_development0.89559403
131MP0001853_heart_inflammation0.88666922
132MP0004130_abnormal_muscle_cell0.87696572
133MP0000465_gastrointestinal_hemorrhage0.87511450
134MP0001346_abnormal_lacrimal_gland0.86883136
135MP0005195_abnormal_posterior_eye0.86673464
136MP0000920_abnormal_myelination0.81716125
137MP0005394_taste/olfaction_phenotype0.81694304
138MP0005499_abnormal_olfactory_system0.81694304
139MP0001845_abnormal_inflammatory_respons0.81490288
140MP0003045_fibrosis0.81138305
141MP0002069_abnormal_eating/drinking_beha0.80777642
142MP0005310_abnormal_salivary_gland0.80504308
143MP0005595_abnormal_vascular_smooth0.78465369
144MP0000343_altered_response_to0.77297535
145MP0004883_abnormal_blood_vessel0.74302415
146MP0003191_abnormal_cellular_cholesterol0.73336154
147MP0003698_abnormal_male_reproductive0.73216890
148MP0002751_abnormal_autonomic_nervous0.72876162
149MP0002090_abnormal_vision0.69388375
150MP0003861_abnormal_nervous_system0.69260328
151MP0003634_abnormal_glial_cell0.68554694
152MP0004145_abnormal_muscle_electrophysio0.67157978
153MP0003121_genomic_imprinting0.66478632
154MP0003632_abnormal_nervous_system0.65957337
155MP0001664_abnormal_digestion0.64554310
156MP0001177_atelectasis0.63625197
157MP0002163_abnormal_gland_morphology0.62607067
158MP0000681_abnormal_thyroid_gland0.62008772
159MP0004484_altered_response_of0.61273385
160MP0002909_abnormal_adrenal_gland0.60948651
161MP0000015_abnormal_ear_pigmentation0.60761815
162MP0000566_synostosis0.59552834
163MP0008789_abnormal_olfactory_epithelium0.58543124
164MP0004085_abnormal_heartbeat0.57305791
165MP0008004_abnormal_stomach_pH0.56700527
166MP0002277_abnormal_respiratory_mucosa0.54434960
167MP0005379_endocrine/exocrine_gland_phen0.54223635

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.82175885
2Epileptic encephalopathy (HP:0200134)4.98782063
3Febrile seizures (HP:0002373)4.76044736
4Focal seizures (HP:0007359)4.57374981
5Myokymia (HP:0002411)4.31910689
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.23314269
7Absent/shortened dynein arms (HP:0200106)4.23314269
8Progressive cerebellar ataxia (HP:0002073)3.99902810
9Hyperventilation (HP:0002883)3.96609639
10Congenital stationary night blindness (HP:0007642)3.86407273
11Visual hallucinations (HP:0002367)3.80691556
12Broad-based gait (HP:0002136)3.53777652
13Atonic seizures (HP:0010819)3.41845122
14Absence seizures (HP:0002121)3.24640611
15Dialeptic seizures (HP:0011146)3.15068000
16Myositis (HP:0100614)3.13333107
17Gaze-evoked nystagmus (HP:0000640)3.11053850
18Abnormal ciliary motility (HP:0012262)3.08535210
19Stomatitis (HP:0010280)3.03550614
20Elevated erythrocyte sedimentation rate (HP:0003565)2.97858295
21Generalized tonic-clonic seizures (HP:0002069)2.97549167
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94955315
23Orchitis (HP:0100796)2.87988069
24Decreased central vision (HP:0007663)2.86783903
25Abnormal respiratory motile cilium physiology (HP:0012261)2.86375646
26Abnormal respiratory motile cilium morphology (HP:0005938)2.83791009
27Abnormal respiratory epithelium morphology (HP:0012253)2.83791009
28Excessive salivation (HP:0003781)2.81129870
29Drooling (HP:0002307)2.81129870
30Absent speech (HP:0001344)2.69747212
31Optic neuritis (HP:0100653)2.68949421
32Retrobulbar optic neuritis (HP:0100654)2.68949421
33Annular pancreas (HP:0001734)2.62934668
34Spondylolisthesis (HP:0003302)2.62350089
35Supranuclear gaze palsy (HP:0000605)2.60699522
36Neuronal loss in central nervous system (HP:0002529)2.56694292
37Abnormality of macular pigmentation (HP:0008002)2.56347424
38Dysostosis multiplex (HP:0000943)2.56252033
39Hemiparesis (HP:0001269)2.55629797
40Mutism (HP:0002300)2.54610052
41Protruding tongue (HP:0010808)2.52664604
42Papilledema (HP:0001085)2.52319880
43Action tremor (HP:0002345)2.51692349
44Gait imbalance (HP:0002141)2.49610571
45Apathy (HP:0000741)2.44895286
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44418814
47Amyloidosis (HP:0011034)2.43069722
48Dyschromatopsia (HP:0007641)2.42819749
49Dysdiadochokinesis (HP:0002075)2.40337698
50Recurrent bacterial skin infections (HP:0005406)2.37183636
51Broad face (HP:0000283)2.36658328
52Poor eye contact (HP:0000817)2.36177298
53Abnormal rod and cone electroretinograms (HP:0008323)2.36028581
54Slow saccadic eye movements (HP:0000514)2.35976617
55Dysmetria (HP:0001310)2.35556476
56Abnormality of liposaccharide metabolism (HP:0010968)2.33761312
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.33761312
58Abnormality of glycolipid metabolism (HP:0010969)2.33761312
59Amblyopia (HP:0000646)2.31598727
60Fetal akinesia sequence (HP:0001989)2.30943798
61Congenital sensorineural hearing impairment (HP:0008527)2.28584039
62Diplopia (HP:0000651)2.28245892
63Abnormality of binocular vision (HP:0011514)2.28245892
64Bony spicule pigmentary retinopathy (HP:0007737)2.25248710
65Epileptiform EEG discharges (HP:0011182)2.23570276
66Genetic anticipation (HP:0003743)2.22678907
67Widely spaced teeth (HP:0000687)2.21909876
68Medial flaring of the eyebrow (HP:0010747)2.21224999
69Mediastinal lymphadenopathy (HP:0100721)2.20880952
70Eczematoid dermatitis (HP:0000976)2.20823367
71Obstructive sleep apnea (HP:0002870)2.20484090
72Recurrent abscess formation (HP:0002722)2.19393889
73Diminished motivation (HP:0000745)2.18732970
74Aortic aneurysm (HP:0004942)2.17653685
75Impaired vibration sensation in the lower limbs (HP:0002166)2.16439236
76Cellulitis (HP:0100658)2.15702291
77Neurofibrillary tangles (HP:0002185)2.15172026
78Nuclear cataract (HP:0100018)2.14669463
79Truncal ataxia (HP:0002078)2.14460850
80Abnormal eating behavior (HP:0100738)2.14178356
81Stereotypic behavior (HP:0000733)2.12521286
82Nephrogenic diabetes insipidus (HP:0009806)2.10500071
83Absent eyebrow (HP:0002223)2.10055698
84Akinesia (HP:0002304)2.07989944
85Choroideremia (HP:0001139)2.07715708
86Inability to walk (HP:0002540)2.05735132
87EEG with generalized epileptiform discharges (HP:0011198)2.04597017
88Polyphagia (HP:0002591)2.04505501
89Peritonitis (HP:0002586)2.03950705
90Ankle clonus (HP:0011448)2.03793394
91Parakeratosis (HP:0001036)2.03510429
92Blue irides (HP:0000635)2.03359507
93Interstitial pulmonary disease (HP:0006530)2.02846968
94Abnormality of macrophages (HP:0004311)2.02714777
95Hemiplegia (HP:0002301)2.01675291
96Severe visual impairment (HP:0001141)2.01605449
97Inappropriate behavior (HP:0000719)2.01581208
98Abnormality of the corticospinal tract (HP:0002492)2.00758062
99Septo-optic dysplasia (HP:0100842)1.99939742
100Abnormality of salivation (HP:0100755)1.98994762
101Lower limb amyotrophy (HP:0007210)1.98362403
102Hypoventilation (HP:0002791)1.95648788
103Disinhibition (HP:0000734)1.95595309
104Congenital primary aphakia (HP:0007707)1.95541722
105Central scotoma (HP:0000603)1.94209026
106Protrusio acetabuli (HP:0003179)1.93201600
107Anxiety (HP:0000739)1.92557781
108Abolished electroretinogram (ERG) (HP:0000550)1.92054668
109Retinal dysplasia (HP:0007973)1.91317671
110Rhinitis (HP:0012384)1.91291360
111Generalized hypopigmentation of hair (HP:0011358)1.88717458
112Urinary bladder sphincter dysfunction (HP:0002839)1.88143250
113Attenuation of retinal blood vessels (HP:0007843)1.88088021
114Torticollis (HP:0000473)1.87675172
115Scanning speech (HP:0002168)1.87206163
116Depression (HP:0000716)1.85932397
117Slender build (HP:0001533)1.85910820
118Distal lower limb amyotrophy (HP:0008944)1.84863277
119Optic nerve hypoplasia (HP:0000609)1.83993866
120Spinal cord lesions (HP:0100561)1.83908042
121Syringomyelia (HP:0003396)1.83908042
122Acute lymphatic leukemia (HP:0006721)1.83266971
123Fair hair (HP:0002286)1.82904137
124Decreased circulating renin level (HP:0003351)1.82532597
125Hypsarrhythmia (HP:0002521)1.81329250
126Keratoconjunctivitis sicca (HP:0001097)1.80991862
127Genu recurvatum (HP:0002816)1.80960065
128Lissencephaly (HP:0001339)1.79879207
129Impaired social interactions (HP:0000735)1.79751938
130Abnormal social behavior (HP:0012433)1.79751938
131Limb dystonia (HP:0002451)1.79314444
132Postural instability (HP:0002172)1.79014680
133Dilatation of the ascending aorta (HP:0005111)1.78967736
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77723665
135Abnormality of polysaccharide metabolism (HP:0011012)1.77723665
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77723665
137Onion bulb formation (HP:0003383)1.77040828
138Vasculitis (HP:0002633)1.75784574
139Nephronophthisis (HP:0000090)1.75307396
140Chest pain (HP:0100749)1.74258784
141Abnormal hair whorl (HP:0010721)1.74154008
142Genital tract atresia (HP:0001827)1.74139206
143Esotropia (HP:0000565)1.74078454
144Spastic gait (HP:0002064)1.73910077
145Sleep apnea (HP:0010535)1.72634825
146Difficulty climbing stairs (HP:0003551)1.72192766
147Aortic regurgitation (HP:0001659)1.71998592
148Recurrent fungal infections (HP:0002841)1.71730364
149Cerebral inclusion bodies (HP:0100314)1.71316316
150Impaired smooth pursuit (HP:0007772)1.70337836
151Pulmonary infiltrates (HP:0002113)1.70281023
152Urinary glycosaminoglycan excretion (HP:0003541)1.70184879
153Mucopolysacchariduria (HP:0008155)1.70184879
154Progressive inability to walk (HP:0002505)1.69966383
155Vascular tortuosity (HP:0004948)1.69817586
156Memory impairment (HP:0002354)1.69582982
157Vaginal atresia (HP:0000148)1.69545687
158Arterial tortuosity (HP:0005116)1.68032090
159Mitral regurgitation (HP:0001653)1.67276239
160Rapidly progressive (HP:0003678)1.65195126
161Episodic fever (HP:0001954)1.64285896
162Hypercortisolism (HP:0001578)1.63708953
163Peripheral hypomyelination (HP:0007182)1.63242503
164Polygenic inheritance (HP:0010982)1.62957742
165Abnormality of ocular smooth pursuit (HP:0000617)1.60839722
166Lower limb asymmetry (HP:0100559)1.60514117
167Lower limb muscle weakness (HP:0007340)1.60236992
168Thrombocytosis (HP:0001894)1.60207252
169Meningitis (HP:0001287)1.59937709
170Loss of speech (HP:0002371)1.57951220
171Autoimmune thrombocytopenia (HP:0001973)1.57178347
172Increased variability in muscle fiber diameter (HP:0003557)1.57025450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.84189035
2MARK14.16382777
3TNIK3.71664448
4EPHA43.62453388
5CASK3.60369307
6MAP2K73.13989899
7IRAK32.57004141
8MAP3K42.48640003
9RIPK12.26798061
10PRPF4B2.19883069
11MAPK132.12155368
12SIK22.05084385
13SIK32.02129193
14MINK11.98286965
15MOS1.95128733
16NTRK21.92387236
17MAP4K11.83807468
18GRK71.82629698
19MAP3K91.67099412
20DAPK21.57255493
21PNCK1.53387121
22RIPK41.51971150
23TAOK21.48779046
24MAP2K31.47178896
25TAOK11.46943411
26PAK61.46081049
27TRIB31.43952953
28PLK21.40591279
29TBK11.36101895
30MAP3K121.34381952
31ICK1.33245819
32FES1.32349217
33TXK1.31284135
34STK381.30321588
35IRAK41.28297532
36CDK51.22748306
37ZAP701.22602046
38EPHB11.22223594
39MAP2K41.21486239
40CDK191.21080553
41LATS21.20633502
42ERN11.20200181
43BLK1.20166834
44KSR11.19339197
45MAP3K131.18946044
46PRKCG1.15983581
47CAMK11.13922874
48PKN11.10167552
49TYK21.09602185
50MAP3K111.09465739
51MARK21.09007219
52NEK61.08926826
53CAMK2A1.08633497
54PRKD31.07379738
55IKBKE1.02322990
56CDK31.01088621
57JAK11.00184350
58KIT0.99853824
59PHKG10.99319485
60PHKG20.99319485
61BMPR20.99290870
62CAMKK10.98158517
63CSK0.97961924
64GRK50.97869705
65OXSR10.96080573
66MAPK70.95629643
67PRKD20.94938494
68DYRK1A0.94669297
69PDGFRA0.93988889
70DDR20.92548821
71WNK10.92208041
72SIK10.91476132
73SYK0.91408877
74DAPK10.89954382
75CDC42BPA0.89607473
76CAMK2B0.89140065
77SGK4940.88474420
78SGK2230.88474420
79HIPK20.85370285
80HCK0.85057296
81JAK30.84911423
82ERBB30.84539145
83TTN0.84145869
84SGK20.81122229
85UHMK10.80024584
86TYRO30.79247072
87DYRK20.79112872
88CCNB10.76853673
89IKBKB0.76558220
90IRAK10.76145621
91BTK0.74636195
92MAP3K10.74603596
93PRKCE0.73981959
94TNK20.71627542
95CSNK1G20.71088635
96BCR0.69578015
97JAK20.69439132
98ARAF0.67699913
99CDK180.67070523
100BMPR1B0.66725171
101SGK10.66219315
102CDK120.64945849
103NME20.64892808
104DYRK1B0.64066036
105ADRBK20.63806528
106MAPK40.63296301
107CDK150.62922198
108PTK2B0.62106208
109IRAK20.61669968
110MATK0.61253119
111WNK30.61041965
112PDGFRB0.60683073
113CAMKK20.60659504
114CAMK1G0.60504061
115GRK10.59812698
116CSF1R0.58831867
117MAP3K30.58312383
118CDK140.57125844
119EPHB20.56378883
120PDK10.56253933
121STK110.56182625
122NME10.55504322
123PINK10.55187861
124TGFBR20.55138276
125PRKCZ0.55082110
126CDK11A0.54845005
127FGR0.54246494
128MAPK150.54141875
129NTRK10.52300224
130LCK0.51967077
131PAK20.51645175
132MUSK0.51406966
133MKNK20.50772191
134CAMK40.50763955
135MAP3K60.49569759
136AKT30.49380984
137CAMK2D0.49375029
138PRKG10.47756826
139ROCK20.46449268
140FER0.46330203
141MAP3K70.45875364
142MAPK120.45843669
143INSRR0.45309706
144FYN0.45135737
145PRKCH0.43455399
146PAK30.43084285
147STK160.42543385
148BRD40.40240406
149STK390.39435916
150CSNK1A1L0.37833400
151KSR20.37123233
152MAP3K140.36884380
153CAMK2G0.36092453
154SGK30.34741234
155PRKCB0.33402448
156PDPK10.33377419
157EIF2AK20.32778684
158CLK10.32434523

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17419550
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82065030
3Synaptic vesicle cycle_Homo sapiens_hsa047212.81098611
4Glutamatergic synapse_Homo sapiens_hsa047242.75166620
5Circadian entrainment_Homo sapiens_hsa047132.68573900
6Phototransduction_Homo sapiens_hsa047442.66222186
7Morphine addiction_Homo sapiens_hsa050322.54747565
8GABAergic synapse_Homo sapiens_hsa047272.52986449
9Olfactory transduction_Homo sapiens_hsa047402.39907326
10Long-term potentiation_Homo sapiens_hsa047202.37987972
11Amphetamine addiction_Homo sapiens_hsa050312.15308905
12Taste transduction_Homo sapiens_hsa047421.99891867
13Salivary secretion_Homo sapiens_hsa049701.98495800
14Serotonergic synapse_Homo sapiens_hsa047261.93590773
15Dopaminergic synapse_Homo sapiens_hsa047281.89521278
16Osteoclast differentiation_Homo sapiens_hsa043801.89477738
17Cholinergic synapse_Homo sapiens_hsa047251.87400012
18Insulin secretion_Homo sapiens_hsa049111.83294570
19Long-term depression_Homo sapiens_hsa047301.73311067
20Axon guidance_Homo sapiens_hsa043601.72393575
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70564900
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69758275
23Calcium signaling pathway_Homo sapiens_hsa040201.68502496
24Leishmaniasis_Homo sapiens_hsa051401.59757746
25Gastric acid secretion_Homo sapiens_hsa049711.58081343
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58078363
27Renin secretion_Homo sapiens_hsa049241.57652008
28B cell receptor signaling pathway_Homo sapiens_hsa046621.52350583
29Oxytocin signaling pathway_Homo sapiens_hsa049211.51524818
30TNF signaling pathway_Homo sapiens_hsa046681.51028959
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49456764
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40931393
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37296654
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33766945
35Acute myeloid leukemia_Homo sapiens_hsa052211.33495187
36Collecting duct acid secretion_Homo sapiens_hsa049661.33138025
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31820493
38Cocaine addiction_Homo sapiens_hsa050301.27358657
39cAMP signaling pathway_Homo sapiens_hsa040241.24456165
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.24238797
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23221708
42Tuberculosis_Homo sapiens_hsa051521.23191025
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22734589
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22642951
45ErbB signaling pathway_Homo sapiens_hsa040121.16192784
46GnRH signaling pathway_Homo sapiens_hsa049121.16114561
47Chronic myeloid leukemia_Homo sapiens_hsa052201.16058191
48Malaria_Homo sapiens_hsa051441.12719839
49Salmonella infection_Homo sapiens_hsa051321.10177254
50Influenza A_Homo sapiens_hsa051641.07609988
51Toxoplasmosis_Homo sapiens_hsa051451.07449342
52Type II diabetes mellitus_Homo sapiens_hsa049301.05469842
53Pertussis_Homo sapiens_hsa051331.05115683
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04236732
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02709017
56Prolactin signaling pathway_Homo sapiens_hsa049171.02318506
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02025951
58Gap junction_Homo sapiens_hsa045401.01418575
59Hepatitis B_Homo sapiens_hsa051611.01146535
60Prion diseases_Homo sapiens_hsa050201.01108867
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99444753
62Non-small cell lung cancer_Homo sapiens_hsa052230.99169230
63Other glycan degradation_Homo sapiens_hsa005110.98988360
64Amoebiasis_Homo sapiens_hsa051460.98019747
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97410243
66Melanogenesis_Homo sapiens_hsa049160.95061110
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94959178
68Measles_Homo sapiens_hsa051620.94940813
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94432903
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.93836516
71Renal cell carcinoma_Homo sapiens_hsa052110.91738002
72Glioma_Homo sapiens_hsa052140.89908026
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.87400971
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86390884
75African trypanosomiasis_Homo sapiens_hsa051430.85430112
76Wnt signaling pathway_Homo sapiens_hsa043100.85425789
77Pancreatic cancer_Homo sapiens_hsa052120.84869059
78Platelet activation_Homo sapiens_hsa046110.83772592
79Allograft rejection_Homo sapiens_hsa053300.83622186
80Shigellosis_Homo sapiens_hsa051310.83017255
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82830461
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82291305
83Estrogen signaling pathway_Homo sapiens_hsa049150.81333764
84Choline metabolism in cancer_Homo sapiens_hsa052310.80267998
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80244936
86mTOR signaling pathway_Homo sapiens_hsa041500.80005429
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.79051243
88MAPK signaling pathway_Homo sapiens_hsa040100.77330160
89Cardiac muscle contraction_Homo sapiens_hsa042600.77096710
90Ras signaling pathway_Homo sapiens_hsa040140.76958594
91Notch signaling pathway_Homo sapiens_hsa043300.76153001
92Hepatitis C_Homo sapiens_hsa051600.75757643
93Legionellosis_Homo sapiens_hsa051340.75392909
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74220794
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73559372
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73248837
97Pancreatic secretion_Homo sapiens_hsa049720.72914016
98Circadian rhythm_Homo sapiens_hsa047100.72328810
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69418488
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.69085552
101Endocytosis_Homo sapiens_hsa041440.67505975
102Vibrio cholerae infection_Homo sapiens_hsa051100.66698821
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.64516447
104Hematopoietic cell lineage_Homo sapiens_hsa046400.64018421
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63745496
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.60713660
107Apoptosis_Homo sapiens_hsa042100.60681599
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60407987
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59971739
110Dilated cardiomyopathy_Homo sapiens_hsa054140.59495769
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57677276
112Rheumatoid arthritis_Homo sapiens_hsa053230.56349855
113Dorso-ventral axis formation_Homo sapiens_hsa043200.52402560
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51459098
115Ether lipid metabolism_Homo sapiens_hsa005650.49522818
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48821506
117Rap1 signaling pathway_Homo sapiens_hsa040150.48533749
118Type I diabetes mellitus_Homo sapiens_hsa049400.48365398
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44344412
120Ovarian steroidogenesis_Homo sapiens_hsa049130.44343961
121Chemokine signaling pathway_Homo sapiens_hsa040620.43107978
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.41457521
123Mineral absorption_Homo sapiens_hsa049780.40784490
124Sphingolipid metabolism_Homo sapiens_hsa006000.40035118
125Thyroid hormone synthesis_Homo sapiens_hsa049180.39706522
126VEGF signaling pathway_Homo sapiens_hsa043700.39380229
127Oocyte meiosis_Homo sapiens_hsa041140.39072240
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38237039
129Endometrial cancer_Homo sapiens_hsa052130.34290297
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34077760
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34003002
132Inositol phosphate metabolism_Homo sapiens_hsa005620.33324566
133Graft-versus-host disease_Homo sapiens_hsa053320.32432817
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32242150
135Alcoholism_Homo sapiens_hsa050340.32113134
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31957207
137Hedgehog signaling pathway_Homo sapiens_hsa043400.31927443
138Glucagon signaling pathway_Homo sapiens_hsa049220.31084403
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30432650
140T cell receptor signaling pathway_Homo sapiens_hsa046600.29919070
141Colorectal cancer_Homo sapiens_hsa052100.28776973
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27981151

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