PRDM9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome organization involved in meiosis (GO:0070192)8.96578338
2male meiosis I (GO:0007141)8.33920242
3synaptonemal complex assembly (GO:0007130)7.81987394
4reciprocal DNA recombination (GO:0035825)7.01574459
5reciprocal meiotic recombination (GO:0007131)7.01574459
6piRNA metabolic process (GO:0034587)6.97424021
7resolution of meiotic recombination intermediates (GO:0000712)6.95703254
8synaptonemal complex organization (GO:0070193)6.94036854
9meiosis I (GO:0007127)6.72986079
10DNA methylation involved in gamete generation (GO:0043046)6.69977331
11male meiosis (GO:0007140)6.36034897
12DNA synthesis involved in DNA repair (GO:0000731)5.78305447
13meiotic nuclear division (GO:0007126)5.45711197
14* meiotic cell cycle process (GO:1903046)5.30179443
15replication fork processing (GO:0031297)4.84407417
16positive regulation of gamma-delta T cell activation (GO:0046645)4.55587674
17sister chromatid cohesion (GO:0007062)4.39689284
18regulation of DNA endoreduplication (GO:0032875)3.95496739
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88018536
20superoxide anion generation (GO:0042554)3.87459637
21* regulation of meiosis I (GO:0060631)3.81602125
22intra-S DNA damage checkpoint (GO:0031573)3.69945290
23centriole replication (GO:0007099)3.65567677
24negative regulation of mast cell activation (GO:0033004)3.63737405
25attachment of spindle microtubules to kinetochore (GO:0008608)3.59846347
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.58454361
27neutrophil activation involved in immune response (GO:0002283)3.51429791
28regulation of B cell receptor signaling pathway (GO:0050855)3.48721776
29positive regulation of cellular amide metabolic process (GO:0034250)3.46600882
30response to peptidoglycan (GO:0032494)3.46445706
31detection of other organism (GO:0098543)3.39698997
32regulation of activation of Janus kinase activity (GO:0010533)3.33646126
33DNA alkylation (GO:0006305)3.32463682
34DNA methylation (GO:0006306)3.32463682
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.22811877
36detection of bacterium (GO:0016045)3.21348345
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17948746
38cellular response to exogenous dsRNA (GO:0071360)3.13256642
39defense response to protozoan (GO:0042832)3.12559697
40detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.12276812
41kynurenine metabolic process (GO:0070189)3.11784000
42regulation of RIG-I signaling pathway (GO:0039535)3.11225743
43double-strand break repair via homologous recombination (GO:0000724)3.06623917
44negative regulation of viral genome replication (GO:0045071)3.06569424
45recombinational repair (GO:0000725)3.06368723
46histone exchange (GO:0043486)3.05282269
47mature B cell differentiation (GO:0002335)3.04025326
48neutrophil activation (GO:0042119)3.03998354
49gene silencing by RNA (GO:0031047)3.02723107
50DNA methylation or demethylation (GO:0044728)3.02517861
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01689061
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.01689061
53NADH dehydrogenase complex assembly (GO:0010257)3.01689061
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00466537
55interkinetic nuclear migration (GO:0022027)2.98893249
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96832049
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96832049
58regulation of B cell differentiation (GO:0045577)2.96199502
59positive regulation of B cell differentiation (GO:0045579)2.95939382
60tryptophan catabolic process (GO:0006569)2.95706749
61indole-containing compound catabolic process (GO:0042436)2.95706749
62indolalkylamine catabolic process (GO:0046218)2.95706749
63omega-hydroxylase P450 pathway (GO:0097267)2.94413424
64cellular response to interleukin-15 (GO:0071350)2.92233956
65T-helper cell differentiation (GO:0042093)2.92230545
66CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.92230545
67regulation of rhodopsin mediated signaling pathway (GO:0022400)2.90106797
68platelet dense granule organization (GO:0060155)2.89199262
69positive regulation of humoral immune response (GO:0002922)2.88331360
70regulation of interleukin-8 secretion (GO:2000482)2.87165424
71neural tube formation (GO:0001841)2.85741483
72positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.82761626
73G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.79640028
74photoreceptor cell maintenance (GO:0045494)2.78802163
75auditory receptor cell stereocilium organization (GO:0060088)2.78405355
76regulation of gamma-delta T cell activation (GO:0046643)2.77146385
77rhodopsin mediated signaling pathway (GO:0016056)2.76961143
78centriole assembly (GO:0098534)2.75581273
79negative regulation of T cell mediated immunity (GO:0002710)2.75312224
80DNA biosynthetic process (GO:0071897)2.75305181
81DNA modification (GO:0006304)2.75231680
82response to protozoan (GO:0001562)2.73447581
83interferon-gamma production (GO:0032609)2.72920538
84mismatch repair (GO:0006298)2.72243877
85type I interferon signaling pathway (GO:0060337)2.71960226
86cellular response to type I interferon (GO:0071357)2.71960226
87response to type I interferon (GO:0034340)2.70267492
88regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.69741191
89protein complex biogenesis (GO:0070271)2.69686038
90oligosaccharide catabolic process (GO:0009313)2.68912982
91dendritic cell chemotaxis (GO:0002407)2.68314334
92granulocyte activation (GO:0036230)2.68266824
93cilium or flagellum-dependent cell motility (GO:0001539)2.68132552
94S-adenosylmethionine metabolic process (GO:0046500)2.66277381
95seminiferous tubule development (GO:0072520)2.65561038
96meiotic cell cycle (GO:0051321)2.64453636
97regulation of mast cell activation (GO:0033003)2.63156047
98adenosine metabolic process (GO:0046085)2.63041199
99chromatin remodeling at centromere (GO:0031055)2.62909874
100CENP-A containing nucleosome assembly (GO:0034080)2.62863748
101NAD biosynthetic process (GO:0009435)2.62699723
102negative regulation of cell killing (GO:0031342)2.62079973
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62079973
104methionine biosynthetic process (GO:0009086)2.61716176
105positive regulation of antigen processing and presentation (GO:0002579)2.61614634
106indolalkylamine metabolic process (GO:0006586)2.61562396
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61259148
108proteasome assembly (GO:0043248)2.60798178
109CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.59314283
110regulation of hexokinase activity (GO:1903299)2.59014577
111regulation of glucokinase activity (GO:0033131)2.59014577
112microtubule anchoring (GO:0034453)2.58898683
113tRNA modification (GO:0006400)2.57008636
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56769878
115positive regulation of interferon-alpha production (GO:0032727)2.56711747
116histone H2A acetylation (GO:0043968)2.55760160
117positive regulation of interferon-beta production (GO:0032728)2.55424152
118phospholipid scrambling (GO:0017121)2.55086042
119production of molecular mediator involved in inflammatory response (GO:0002532)2.54845704
120I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.54054896
121negative regulation of execution phase of apoptosis (GO:1900118)2.53752720
122retinal cone cell development (GO:0046549)2.53214618
123rRNA modification (GO:0000154)2.52741807
124regulation of T cell mediated cytotoxicity (GO:0001914)2.52597990
125dendritic cell migration (GO:0036336)2.52563048
126T cell migration (GO:0072678)2.52357958
127tryptophan metabolic process (GO:0006568)2.51829231
128alpha-beta T cell differentiation involved in immune response (GO:0002293)2.51555042
129alpha-beta T cell activation involved in immune response (GO:0002287)2.51555042
130T cell differentiation involved in immune response (GO:0002292)2.51555042
131mitochondrial respiratory chain complex assembly (GO:0033108)2.51485036
132axoneme assembly (GO:0035082)2.50504875
133cellular biogenic amine catabolic process (GO:0042402)2.50467472
134amine catabolic process (GO:0009310)2.50467472
135germinal center formation (GO:0002467)2.49932062
136telomere maintenance via telomerase (GO:0007004)2.49931348
137L-methionine salvage (GO:0071267)2.49761205
138L-methionine biosynthetic process (GO:0071265)2.49761205
139amino acid salvage (GO:0043102)2.49761205
140regulation of histone H3-K9 methylation (GO:0051570)2.49590924
141positive regulation of T cell migration (GO:2000406)2.49513922
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49357807
143negative regulation of myeloid cell apoptotic process (GO:0033033)2.49122506
144translesion synthesis (GO:0019985)2.49100617
145fertilization (GO:0009566)2.48831151
146monoubiquitinated protein deubiquitination (GO:0035520)2.48727097
147detection of chemical stimulus involved in sensory perception (GO:0050907)2.48553815
148* DNA recombination (GO:0006310)2.47989009
149centrosome organization (GO:0051297)2.47775636
150cellular response to gamma radiation (GO:0071480)2.46540650
151negative regulation of DNA recombination (GO:0045910)2.46512384
152regulation of antigen processing and presentation (GO:0002577)2.46086024
153eye photoreceptor cell development (GO:0042462)2.45700864
154methionine metabolic process (GO:0006555)2.45609973
155CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.45562696
156protein localization to chromosome (GO:0034502)2.45138688
157positive regulation of isotype switching (GO:0045830)2.44902405
158mature B cell differentiation involved in immune response (GO:0002313)2.44750203
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43749037
160B cell proliferation (GO:0042100)2.43601226
161response to pheromone (GO:0019236)2.43515616
162myeloid dendritic cell activation (GO:0001773)2.43513362
163modulation by virus of host process (GO:0019054)2.43058080
164protein K6-linked ubiquitination (GO:0085020)2.43051365
165regulation of mast cell degranulation (GO:0043304)2.42794005
166regulation of interferon-alpha production (GO:0032647)2.41796946
167DNA replication-dependent nucleosome assembly (GO:0006335)2.41192105
168DNA replication-dependent nucleosome organization (GO:0034723)2.41192105
169negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.41081606
170microtubule organizing center organization (GO:0031023)2.40463255
171positive regulation of lymphocyte migration (GO:2000403)2.39914373
172positive regulation of B cell activation (GO:0050871)2.39859014
173mitochondrial RNA metabolic process (GO:0000959)2.39710488
174detection of external biotic stimulus (GO:0098581)2.39422985
175respiratory chain complex IV assembly (GO:0008535)2.39078865
176regulation of isotype switching to IgG isotypes (GO:0048302)2.39067756
177meiotic chromosome segregation (GO:0045132)2.38099685
178natural killer cell activation involved in immune response (GO:0002323)2.37845146
179regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.37587007
180detection of molecule of bacterial origin (GO:0032490)2.37265654
181cellular response to interferon-beta (GO:0035458)2.37120065
182chromosome organization (GO:0051276)2.36099766
183imidazole-containing compound metabolic process (GO:0052803)2.35950687
184regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.35299764
185regulation of mitotic spindle checkpoint (GO:1903504)2.35299764
186response to interferon-alpha (GO:0035455)2.35111495
187hydrogen peroxide biosynthetic process (GO:0050665)2.34728111
188photoreceptor cell development (GO:0042461)2.34255300
189positive regulation of B cell proliferation (GO:0030890)2.34030536
190purinergic nucleotide receptor signaling pathway (GO:0035590)2.33730212
191B cell differentiation (GO:0030183)2.33570838
192replicative senescence (GO:0090399)2.33539075
193respiratory burst (GO:0045730)2.32890340
194positive regulation of B cell mediated immunity (GO:0002714)2.32502308
195synapsis (GO:0007129)11.1608905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.68670275
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.57039605
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.01934099
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66023068
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.54020584
6ZNF274_21170338_ChIP-Seq_K562_Hela3.40763807
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35340973
8VDR_22108803_ChIP-Seq_LS180_Human3.31290145
9IGF1R_20145208_ChIP-Seq_DFB_Human3.30069256
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.12526039
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.11426960
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.83604032
13EZH2_22144423_ChIP-Seq_EOC_Human2.72158784
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.64378605
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59674146
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48921910
17GBX2_23144817_ChIP-Seq_PC3_Human2.26890936
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.24136859
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.23537953
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.20112545
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18286821
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17395699
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13968224
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.11391766
25FUS_26573619_Chip-Seq_HEK293_Human2.09175759
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08611111
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08604314
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.04804235
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98042687
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97109511
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96394202
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93979469
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93681201
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93283897
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.93198902
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82257483
37TP53_22573176_ChIP-Seq_HFKS_Human1.79599430
38STAT3_18555785_Chip-Seq_ESCs_Mouse1.79310593
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77437592
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77331174
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74095699
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74067314
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72756273
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.72615798
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.71341373
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70072758
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.69729680
48RUNX1_27457419_Chip-Seq_LIVER_Mouse1.69066051
49NMYC_18555785_Chip-Seq_ESCs_Mouse1.68083868
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.67572756
51VDR_23849224_ChIP-Seq_CD4+_Human1.67132131
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66804649
53P53_22387025_ChIP-Seq_ESCs_Mouse1.66461593
54E2F7_22180533_ChIP-Seq_HELA_Human1.66331475
55MYC_18940864_ChIP-ChIP_HL60_Human1.64373526
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.63821024
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.63613126
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.63075639
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62770919
60SCL_19346495_ChIP-Seq_HPC-7_Human1.61087015
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59600677
62ELK1_19687146_ChIP-ChIP_HELA_Human1.59370439
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55697800
64P300_18555785_Chip-Seq_ESCs_Mouse1.54824565
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.54311539
66RUNX_20019798_ChIP-Seq_JUKART_Human1.54128902
67ZFX_18555785_Chip-Seq_ESCs_Mouse1.53417296
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.51633350
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50732332
70PU1_27457419_Chip-Seq_LIVER_Mouse1.50253393
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.48465456
72IRF1_19129219_ChIP-ChIP_H3396_Human1.48111827
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47716733
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47704104
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.45521803
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45175367
77NANOG_19829295_ChIP-Seq_ESCs_Human1.44483064
78SOX2_19829295_ChIP-Seq_ESCs_Human1.44483064
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.44210906
80* STAT3_23295773_ChIP-Seq_U87_Human1.42089608
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41524559
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41404696
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.40618095
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40453313
85CBP_20019798_ChIP-Seq_JUKART_Human1.40383811
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40383811
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38316191
88P300_19829295_ChIP-Seq_ESCs_Human1.36219639
89FOXP3_21729870_ChIP-Seq_TREG_Human1.36139868
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.35957328
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35050938
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34599710
93TAF15_26573619_Chip-Seq_HEK293_Human1.34389993
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.33261666
95BCAT_22108803_ChIP-Seq_LS180_Human1.33231672
96TCF4_23295773_ChIP-Seq_U87_Human1.33226593
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.32529004
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32457827
99GATA1_22025678_ChIP-Seq_K562_Human1.32259082
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31677812
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30160684
102RNF2_27304074_Chip-Seq_NSC_Mouse1.29660643
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.29125987
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28912191
105* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28272164
106* FOXA1_25329375_ChIP-Seq_VCAP_Human1.28272164
107ETS1_20019798_ChIP-Seq_JURKAT_Human1.28170500
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27422469
109CTCF_18555785_Chip-Seq_ESCs_Mouse1.27331548
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27297387
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25525250
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24722326
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24500060
114* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23531635
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23317480
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23235442
117* TAL1_26923725_Chip-Seq_HPCs_Mouse1.19141749
118* NCOR_22424771_ChIP-Seq_293T_Human1.18740730
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.18649869
120HOXB7_26014856_ChIP-Seq_BT474_Human1.17712010
121SPI1_23547873_ChIP-Seq_NB4_Human1.17388225
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.16690701
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16381888
124* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16286029
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.15519960
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13147196
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.11138146
128RUNX2_22187159_ChIP-Seq_PCA_Human1.10849007
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10760492
130GATA3_26560356_Chip-Seq_TH1_Human1.09057612
131TCF4_22108803_ChIP-Seq_LS180_Human1.08896152
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08471305
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07870696
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06945663
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06454815
136EWS_26573619_Chip-Seq_HEK293_Human1.05523711
137PIAS1_25552417_ChIP-Seq_VCAP_Human1.05009402
138* AR_25329375_ChIP-Seq_VCAP_Human1.04631069
139AR_20517297_ChIP-Seq_VCAP_Human1.04535618
140* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04038869
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03927892
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03811115
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03555113
144STAT1_17558387_ChIP-Seq_HELA_Human1.01705785
145ETV1_20927104_ChIP-Seq_GIST48_Human1.00878569
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00041209
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99981891
148VDR_24787735_ChIP-Seq_THP-1_Human0.99921066
149CDX2_22108803_ChIP-Seq_LS180_Human0.99109766
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98841564
151* PU_27001747_Chip-Seq_BMDM_Mouse0.98449968
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98271031
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.98269609
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97962554
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97688228
156PHF8_20622853_ChIP-Seq_HELA_Human0.97655836
157ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96901635
158RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95558864
159* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95349293
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95142935
161ER_23166858_ChIP-Seq_MCF-7_Human0.92994671
162MYB_26560356_Chip-Seq_TH2_Human0.91875293
163RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91410155
164* SRF_21415370_ChIP-Seq_HL-1_Mouse0.91343655
165GATA3_26560356_Chip-Seq_TH2_Human0.87845548
166SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87833506
167LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87087383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.14027859
2MP0001835_abnormal_antigen_presentation3.74691026
3MP0003646_muscle_fatigue3.27110088
4MP0006292_abnormal_olfactory_placode3.09115731
5MP0002160_abnormal_reproductive_system2.95111993
6MP0004381_abnormal_hair_follicle2.86720971
7* MP0002210_abnormal_sex_determination2.70525540
8MP0009785_altered_susceptibility_to2.70329050
9MP0001188_hyperpigmentation2.67689592
10MP0005671_abnormal_response_to2.66775355
11MP0002148_abnormal_hypersensitivity_rea2.57064586
12MP0005075_abnormal_melanosome_morpholog2.48289016
13MP0000015_abnormal_ear_pigmentation2.44052133
14* MP0001929_abnormal_gametogenesis2.43304222
15MP0001790_abnormal_immune_system2.42929741
16MP0005387_immune_system_phenotype2.42929741
17MP0003724_increased_susceptibility_to2.39838976
18MP0004147_increased_porphyrin_level2.35058463
19MP0008057_abnormal_DNA_replication2.26564858
20MP0001800_abnormal_humoral_immune2.23631774
21MP0002132_abnormal_respiratory_system2.21689601
22* MP0003698_abnormal_male_reproductive2.19668853
23MP0005389_reproductive_system_phenotype2.18999009
24* MP0001145_abnormal_male_reproductive2.14525922
25MP0005000_abnormal_immune_tolerance2.11325890
26MP0003136_yellow_coat_color2.09845537
27MP0002419_abnormal_innate_immunity2.09119080
28* MP0000653_abnormal_sex_gland2.06881404
29MP0002452_abnormal_antigen_presenting2.00355833
30MP0005025_abnormal_response_to1.99973411
31MP0002009_preneoplasia1.99612695
32MP0000566_synostosis1.96529176
33MP0010094_abnormal_chromosome_stability1.95751044
34MP0002723_abnormal_immune_serum1.92154441
35MP0005551_abnormal_eye_electrophysiolog1.85472912
36MP0003011_delayed_dark_adaptation1.83770887
37MP0005451_abnormal_body_composition1.83095437
38MP0001986_abnormal_taste_sensitivity1.81937380
39MP0005645_abnormal_hypothalamus_physiol1.80834456
40MP0002277_abnormal_respiratory_mucosa1.79144852
41MP0004885_abnormal_endolymph1.78933884
42MP0001819_abnormal_immune_cell1.76818846
43MP0005410_abnormal_fertilization1.76302834
44MP0000685_abnormal_immune_system1.76248798
45MP0002420_abnormal_adaptive_immunity1.75926061
46MP0005174_abnormal_tail_pigmentation1.73982879
47MP0006082_CNS_inflammation1.70653210
48MP0003763_abnormal_thymus_physiology1.70253169
49MP0003436_decreased_susceptibility_to1.69223270
50MP0004782_abnormal_surfactant_physiolog1.60064670
51MP0005464_abnormal_platelet_physiology1.56937211
52MP0000372_irregular_coat_pigmentation1.51682318
53MP0001853_heart_inflammation1.47437448
54MP0002405_respiratory_system_inflammati1.47431728
55MP0009764_decreased_sensitivity_to1.42966194
56MP0002876_abnormal_thyroid_physiology1.39196499
57MP0002163_abnormal_gland_morphology1.38136056
58MP0002095_abnormal_skin_pigmentation1.38106041
59MP0009697_abnormal_copulation1.37246005
60MP0000716_abnormal_immune_system1.34080675
61MP0006276_abnormal_autonomic_nervous1.31890781
62MP0002398_abnormal_bone_marrow1.31797425
63MP0003195_calcinosis1.31364518
64MP0002166_altered_tumor_susceptibility1.30317043
65MP0001324_abnormal_eye_pigmentation1.30212650
66MP0005310_abnormal_salivary_gland1.29286481
67MP0002006_tumorigenesis1.28683961
68MP0008872_abnormal_physiological_respon1.26799003
69MP0002638_abnormal_pupillary_reflex1.26403448
70MP0002735_abnormal_chemical_nociception1.25801526
71MP0003941_abnormal_skin_development1.22882237
72MP0001845_abnormal_inflammatory_respons1.21917916
73MP0003786_premature_aging1.20662927
74MP0002234_abnormal_pharynx_morphology1.18563455
75MP0010155_abnormal_intestine_physiology1.17588292
76MP0000689_abnormal_spleen_morphology1.17507036
77* MP0003699_abnormal_female_reproductive1.17146278
78MP0001764_abnormal_homeostasis1.16777694
79MP0004043_abnormal_pH_regulation1.16313323
80MP0009333_abnormal_splenocyte_physiolog1.15810278
81MP0004019_abnormal_vitamin_homeostasis1.15408255
82MP0008995_early_reproductive_senescence1.15336684
83MP0008260_abnormal_autophagy1.14822100
84MP0005379_endocrine/exocrine_gland_phen1.14652371
85MP0005171_absent_coat_pigmentation1.14594382
86MP0001502_abnormal_circadian_rhythm1.12759518
87MP0000631_abnormal_neuroendocrine_gland1.12408722
88MP0003121_genomic_imprinting1.11112139
89MP0001984_abnormal_olfaction1.10862896
90MP0008469_abnormal_protein_level1.10256888
91* MP0002161_abnormal_fertility/fecundity1.08722328
92MP0001545_abnormal_hematopoietic_system1.08484039
93MP0005397_hematopoietic_system_phenotyp1.08484039
94MP0005670_abnormal_white_adipose1.07368660
95MP0002396_abnormal_hematopoietic_system1.06255786
96MP0001186_pigmentation_phenotype1.05013335
97MP0006036_abnormal_mitochondrial_physio1.03867015
98MP0000569_abnormal_digit_pigmentation1.03672579
99MP0005253_abnormal_eye_physiology1.01465938
100MP0003183_abnormal_peptide_metabolism1.01303315
101MP0006072_abnormal_retinal_apoptosis1.01176939
102MP0005408_hypopigmentation1.00940234
103MP0002102_abnormal_ear_morphology1.00704540
104MP0002429_abnormal_blood_cell1.00421103
105MP0000371_diluted_coat_color0.99633418
106MP0002722_abnormal_immune_system0.98939026
107* MP0008058_abnormal_DNA_repair0.98096803
108MP0003191_abnormal_cellular_cholesterol0.97719037
109MP0002938_white_spotting0.96820735
110MP0004510_myositis0.95346363
111MP0009278_abnormal_bone_marrow0.94261084
112MP0002998_abnormal_bone_remodeling0.93853844
113MP0008875_abnormal_xenobiotic_pharmacok0.93194075
114MP0003880_abnormal_central_pattern0.92869674
115MP0001501_abnormal_sleep_pattern0.92022779
116MP0005409_darkened_coat_color0.89445631
117MP0003315_abnormal_perineum_morphology0.89031051
118MP0001873_stomach_inflammation0.87734956
119MP0003186_abnormal_redox_activity0.86094663
120MP0003693_abnormal_embryo_hatching0.85237979
121MP0002653_abnormal_ependyma_morphology0.83686527
122MP0009046_muscle_twitch0.83454766
123MP0005646_abnormal_pituitary_gland0.83353712
124MP0005332_abnormal_amino_acid0.82946727
125* MP0001119_abnormal_female_reproductive0.82019092
126MP0010386_abnormal_urinary_bladder0.81885251
127MP0000465_gastrointestinal_hemorrhage0.80573754
128MP0001529_abnormal_vocalization0.78572256
129MP0003787_abnormal_imprinting0.78143058
130MP0005647_abnormal_sex_gland0.77089490
131MP0000490_abnormal_crypts_of0.76239857
132MP0002138_abnormal_hepatobiliary_system0.75869829
133MP0001486_abnormal_startle_reflex0.75628109
134MP0005085_abnormal_gallbladder_physiolo0.75474700
135MP0002933_joint_inflammation0.74783536
136MP0004947_skin_inflammation0.72389755
137MP0003718_maternal_effect0.71960657
138MP0003828_pulmonary_edema0.71617791
139MP0001968_abnormal_touch/_nociception0.71597871
140MP0002837_dystrophic_cardiac_calcinosis0.71543318
141MP0002229_neurodegeneration0.71104277
142MP0002075_abnormal_coat/hair_pigmentati0.70768355
143MP0005423_abnormal_somatic_nervous0.70740496
144MP0001919_abnormal_reproductive_system0.69996531
145MP0000427_abnormal_hair_cycle0.69865833
146MP0000681_abnormal_thyroid_gland0.66535999
147MP0005084_abnormal_gallbladder_morpholo0.66316106
148MP0000703_abnormal_thymus_morphology0.65664871
149MP0009745_abnormal_behavioral_response0.63078915
150MP0003077_abnormal_cell_cycle0.62550258
151MP0000678_abnormal_parathyroid_gland0.59396985
152MP0003111_abnormal_nucleus_morphology0.59241490
153MP0004145_abnormal_muscle_electrophysio0.58996985
154MP0003950_abnormal_plasma_membrane0.57240991
155MP0002557_abnormal_social/conspecific_i0.56202767
156MP0002733_abnormal_thermal_nociception0.55972618
157MP0002139_abnormal_hepatobiliary_system0.55595331
158MP0005195_abnormal_posterior_eye0.54967356
159MP0001661_extended_life_span0.54953228
160MP0006035_abnormal_mitochondrial_morpho0.54831159
161MP0008007_abnormal_cellular_replicative0.53344923
162MP0005167_abnormal_blood-brain_barrier0.53274091
163MP0001963_abnormal_hearing_physiology0.53084149

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.58466885
2Chromsome breakage (HP:0040012)4.07024878
3Congenital stationary night blindness (HP:0007642)3.79036118
4Nephronophthisis (HP:0000090)3.35139161
5Agammaglobulinemia (HP:0004432)3.20842422
6Pancreatic cysts (HP:0001737)3.17701838
7Recurrent abscess formation (HP:0002722)3.12858249
8Birth length less than 3rd percentile (HP:0003561)3.06810565
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05960833
10Spontaneous abortion (HP:0005268)2.98649314
11Optic neuritis (HP:0100653)2.98312989
12Retrobulbar optic neuritis (HP:0100654)2.98312989
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97778251
14Abnormality of alanine metabolism (HP:0010916)2.97778251
15Hyperalaninemia (HP:0003348)2.97778251
16Prostate neoplasm (HP:0100787)2.97590066
17Abnormality of the renal medulla (HP:0100957)2.87912016
18Recurrent cutaneous fungal infections (HP:0011370)2.86756120
19Chronic mucocutaneous candidiasis (HP:0002728)2.86756120
20Abnormal rod and cone electroretinograms (HP:0008323)2.83369017
21Renal cortical cysts (HP:0000803)2.77520443
22Congenital sensorineural hearing impairment (HP:0008527)2.76415721
23Clubbing of toes (HP:0100760)2.74992724
24Meningitis (HP:0001287)2.74752231
25Joint hemorrhage (HP:0005261)2.72982466
26Attenuation of retinal blood vessels (HP:0007843)2.71828973
27Volvulus (HP:0002580)2.70102373
28Recurrent bacterial skin infections (HP:0005406)2.67829076
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61732114
30Reduced antithrombin III activity (HP:0001976)2.60695978
31Mediastinal lymphadenopathy (HP:0100721)2.56472819
32Eczematoid dermatitis (HP:0000976)2.55710311
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.54192995
34True hermaphroditism (HP:0010459)2.51789833
35Hepatocellular necrosis (HP:0001404)2.49962495
36Prolonged partial thromboplastin time (HP:0003645)2.49172036
37Abnormality of the prostate (HP:0008775)2.48385763
38Osteomalacia (HP:0002749)2.47438317
39Abolished electroretinogram (ERG) (HP:0000550)2.46007417
40Type I transferrin isoform profile (HP:0003642)2.45521690
41Abnormality of the renal collecting system (HP:0004742)2.44393953
42Bony spicule pigmentary retinopathy (HP:0007737)2.43086661
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.43034193
44Orchitis (HP:0100796)2.42697412
45Recurrent sinusitis (HP:0011108)2.42509586
46Abnormality of the preputium (HP:0100587)2.41731042
47Small intestinal stenosis (HP:0012848)2.40846763
48Duodenal stenosis (HP:0100867)2.40846763
49Abnormality of midbrain morphology (HP:0002418)2.40478766
50Molar tooth sign on MRI (HP:0002419)2.40478766
51Recurrent pneumonia (HP:0006532)2.39385352
52Duplicated collecting system (HP:0000081)2.38626691
53Abnormality of the labia minora (HP:0012880)2.37562536
54Tubulointerstitial nephritis (HP:0001970)2.36794889
55Recurrent fungal infections (HP:0002841)2.36659585
56Pigmentary retinal degeneration (HP:0001146)2.35775183
57Absent speech (HP:0001344)2.32016379
58Patchy hypopigmentation of hair (HP:0011365)2.31481631
59Decreased central vision (HP:0007663)2.31246706
60Recurrent skin infections (HP:0001581)2.30149253
61Constricted visual fields (HP:0001133)2.29390529
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29362436
63Supernumerary spleens (HP:0009799)2.28842212
64Hypoplasia of the fovea (HP:0007750)2.28678728
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.28678728
66Hyperventilation (HP:0002883)2.25600818
67Chronic obstructive pulmonary disease (HP:0006510)2.24896019
68Obstructive lung disease (HP:0006536)2.24896019
69Myositis (HP:0100614)2.24561795
70Abnormality of chromosome stability (HP:0003220)2.24139005
71Cystic liver disease (HP:0006706)2.23129664
72Thyroiditis (HP:0100646)2.22891267
73Lipid accumulation in hepatocytes (HP:0006561)2.22635850
74Increased IgM level (HP:0003496)2.22635719
75Panhypogammaglobulinemia (HP:0003139)2.20117433
76Abnormality of cochlea (HP:0000375)2.19778505
77Vasculitis (HP:0002633)2.19068245
78Meckel diverticulum (HP:0002245)2.18020401
79Alveolar cell carcinoma (HP:0006519)2.17742059
80Encephalitis (HP:0002383)2.16571775
81Increased CSF lactate (HP:0002490)2.15938645
82IgM deficiency (HP:0002850)2.12648514
83Dyschromatopsia (HP:0007641)2.11749096
84Hypothermia (HP:0002045)2.11456524
85Recurrent gram-negative bacterial infections (HP:0005420)2.11002637
86Sloping forehead (HP:0000340)2.10773732
87Gaze-evoked nystagmus (HP:0000640)2.10459844
88Azoospermia (HP:0000027)2.09331791
89Chronic diarrhea (HP:0002028)2.08227892
90Hepatic necrosis (HP:0002605)2.07783175
91Abnormality of the renal cortex (HP:0011035)2.07572121
92Febrile seizures (HP:0002373)2.06430911
93Abnormality of DNA repair (HP:0003254)2.05755568
94Gingival bleeding (HP:0000225)2.05352577
95Dry hair (HP:0011359)2.03918555
96Abnormality of the ileum (HP:0001549)2.03417549
97White forelock (HP:0002211)2.02164953
98Lip pit (HP:0100267)2.02148294
99Severe visual impairment (HP:0001141)2.01391811
100Prolonged bleeding time (HP:0003010)2.00994209
101Abnormality of the duodenum (HP:0002246)2.00910588
102Albinism (HP:0001022)1.99889531
103Mitochondrial inheritance (HP:0001427)1.99009612
104Abnormal hair whorl (HP:0010721)1.98702957
105Abnormality of incisor morphology (HP:0011063)1.98484146
106Astigmatism (HP:0000483)1.97649261
107Severe combined immunodeficiency (HP:0004430)1.97304994
108Increased hepatocellular lipid droplets (HP:0006565)1.96948452
109Pendular nystagmus (HP:0012043)1.96088146
110Hypergonadotropic hypogonadism (HP:0000815)1.95922924
111Homocystinuria (HP:0002156)1.95127107
112Abnormality of homocysteine metabolism (HP:0010919)1.95127107
113Gonadotropin excess (HP:0000837)1.94240763
114Recurrent lower respiratory tract infections (HP:0002783)1.93461793
115Chronic hepatic failure (HP:0100626)1.92603152
116Abnormality of the fingertips (HP:0001211)1.92239884
117Male pseudohermaphroditism (HP:0000037)1.92238187
118Ectopic kidney (HP:0000086)1.92148644
119Keratoconjunctivitis sicca (HP:0001097)1.91298505
120Anhidrosis (HP:0000970)1.90952881
121Recurrent viral infections (HP:0004429)1.90716433
122Myelodysplasia (HP:0002863)1.90173535
123Type 2 muscle fiber atrophy (HP:0003554)1.89831114
124Increased intramyocellular lipid droplets (HP:0012240)1.89069845
125Abnormality of macular pigmentation (HP:0008002)1.88776486
126Abnormality of T cell number (HP:0011839)1.87847734
127Thyroid-stimulating hormone excess (HP:0002925)1.86894235
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.86665574
129Absent/shortened dynein arms (HP:0200106)1.86665574
130Abnormality of the carotid arteries (HP:0005344)1.86092393
131Methylmalonic acidemia (HP:0002912)1.85926725
132Conjugated hyperbilirubinemia (HP:0002908)1.85397058
133T lymphocytopenia (HP:0005403)1.85376173
134Oligodactyly (hands) (HP:0001180)1.85328934
135Abnormal respiratory motile cilium morphology (HP:0005938)1.84428201
136Abnormal respiratory epithelium morphology (HP:0012253)1.84428201
137Fair hair (HP:0002286)1.83547447
1383-Methylglutaconic aciduria (HP:0003535)1.83280353
139Pancreatic fibrosis (HP:0100732)1.83204936
140Abnormality of secondary sexual hair (HP:0009888)1.82827246
141Abnormality of the axillary hair (HP:0100134)1.82827246
142Gingivitis (HP:0000230)1.82065051
143Medial flaring of the eyebrow (HP:0010747)1.82055223
144Petechiae (HP:0000967)1.81681122
145Abnormality of macrophages (HP:0004311)1.81491388
146Chorioretinal atrophy (HP:0000533)1.81381335
147Impaired vibration sensation in the lower limbs (HP:0002166)1.81197033
148Basal ganglia calcification (HP:0002135)1.80848382
149Stomach cancer (HP:0012126)1.80541474
150Abnormal biliary tract physiology (HP:0012439)1.80513395
151Small hand (HP:0200055)1.78522863
152Increased serum lactate (HP:0002151)1.77414763
153Abnormality of the fovea (HP:0000493)1.76960155
154Congenital hepatic fibrosis (HP:0002612)1.76431573
155Nephrogenic diabetes insipidus (HP:0009806)1.76186943
156CNS demyelination (HP:0007305)1.76082323
157Postaxial foot polydactyly (HP:0001830)1.75916545
158Renal Fanconi syndrome (HP:0001994)1.75380255
159Triphalangeal thumb (HP:0001199)1.74833684
160Bile duct proliferation (HP:0001408)1.74098737
161Cerebral hypomyelination (HP:0006808)1.71765190
162Increased muscle lipid content (HP:0009058)1.71740601
163Morphological abnormality of the inner ear (HP:0011390)1.69281677
164Respiratory difficulties (HP:0002880)1.69031668
165Abnormal respiratory motile cilium physiology (HP:0012261)1.68176844
166Diastasis recti (HP:0001540)1.68077515
167Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68040513
168Reticulocytopenia (HP:0001896)1.66893019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.52273303
2MAP3K143.28540065
3CDK193.04917672
4IRAK42.87807499
5TXK2.87037605
6ZAK2.80597680
7CCNB12.54674549
8MUSK2.50592208
9PDK22.49302330
10MKNK22.25314016
11STK162.16858877
12CASK2.14282653
13GRK12.12749383
14MAP3K42.07092494
15MAP4K21.98643661
16MKNK11.94595093
17WNK31.92875600
18TNIK1.91032688
19BRSK21.88747886
20IKBKE1.84948356
21PBK1.81312732
22BLK1.77263759
23EIF2AK21.76619348
24IKBKB1.75569333
25BMPR21.73647543
26TRIM281.67861129
27NUAK11.65587445
28AKT31.63956683
29PLK41.55887429
30TEC1.54738082
31YES11.53939542
32MARK31.53401295
33MAP4K11.53025782
34BUB11.48639466
35SIK21.47783390
36NEK61.44154333
37NTRK31.42779563
38JAK31.39623374
39PRPF4B1.38822700
40ACVR1B1.35842600
41CHUK1.34847007
42TNK21.33026086
43BTK1.28385602
44NEK21.27133539
45NLK1.27059640
46SRPK11.25443847
47INSRR1.25015927
48BCKDK1.24823736
49OXSR11.24426178
50JAK11.24132953
51CDK31.23208522
52SGK21.22502422
53IRAK11.22091838
54TRPM71.19944714
55ERBB31.18229151
56GRK71.17918795
57IRAK21.17231384
58PNCK1.13470063
59MATK1.11911652
60TTK1.09796755
61WNK41.08338280
62SIK31.06938813
63WEE11.06625143
64PIM11.01872466
65NEK91.00455868
66SYK1.00182355
67TAOK30.99367732
68PLK10.99000198
69TLK10.97149688
70RIPK40.94669834
71PIM20.94191834
72TGFBR20.92163884
73TYK20.91215265
74ADRBK20.90711599
75KIT0.90330459
76STK40.89811694
77TBK10.89318331
78CLK10.88674950
79MST40.87217053
80LYN0.87006723
81BMPR1B0.85489515
82STK30.83272057
83TIE10.80365768
84STK38L0.79076776
85STK240.78946097
86FRK0.78943706
87CHEK20.78911942
88TAOK20.78705499
89PINK10.77708138
90NEK10.75360432
91ADRBK10.74438164
92NME20.70949611
93LATS10.70760531
94FGFR30.69876031
95ERBB20.69586599
96MAP2K70.68833613
97BRD40.66460129
98PTK2B0.65568165
99ATM0.65127681
100HCK0.64946521
101AURKA0.64255579
102ZAP700.62964473
103VRK10.62414697
104CSF1R0.61978391
105CSK0.57653162
106SGK30.57298755
107MAPK70.57003533
108LCK0.55459955
109CAMK10.54106749
110CDC70.53881865
111RPS6KB10.53013154
112PKN10.51989821
113PIK3CA0.51114606
114MAP2K60.49901859
115DAPK20.49615136
116ITK0.48025346
117EIF2AK30.47482296
118RPS6KA50.47471717
119MAP3K70.46989110
120MAP3K130.46012308
121MAPK120.45883245
122PIK3CG0.43324189
123MAPK150.43028142
124SGK4940.42411891
125SGK2230.42411891
126OBSCN0.41757717
127PRKCE0.41246116
128STK380.41206649
129PRKD20.40643484
130MAPK130.40522554
131NTRK20.40458912
132EIF2AK10.40370868
133RPS6KA60.40338040
134CHEK10.40319806
135PRKAA20.40100353
136MAP2K20.39720299
137ABL10.39567233
138CDK90.39549869
139RPS6KB20.39256854
140PRKCQ0.39176883
141CSNK2A10.38551565
142MAP3K30.38010594
143CDK10.37751727
144CSNK1E0.37198864
145ATR0.36744147
146MAP2K30.36658073
147CDK80.35193739
148STK390.33832892
149MAPK30.33827137
150GRK60.33279722
151BCR0.32669796
152PRKCI0.32364151
153CDK20.31812995
154EGFR0.31782137
155CSNK2A20.31267504

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.57287828
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.00110137
3Olfactory transduction_Homo sapiens_hsa047402.83656222
4Primary immunodeficiency_Homo sapiens_hsa053402.73155199
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.69801366
6Allograft rejection_Homo sapiens_hsa053302.64843137
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.44576083
8Mismatch repair_Homo sapiens_hsa034302.41315004
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31117547
10Autoimmune thyroid disease_Homo sapiens_hsa053202.20778912
11Graft-versus-host disease_Homo sapiens_hsa053322.15624547
12Propanoate metabolism_Homo sapiens_hsa006402.15012947
13Fanconi anemia pathway_Homo sapiens_hsa034602.09447896
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.08777006
15Selenocompound metabolism_Homo sapiens_hsa004501.93977806
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93077207
17Staphylococcus aureus infection_Homo sapiens_hsa051501.86904412
18Measles_Homo sapiens_hsa051621.82837627
19Hematopoietic cell lineage_Homo sapiens_hsa046401.75106588
20RNA transport_Homo sapiens_hsa030131.70075260
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62879111
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60706467
23Leishmaniasis_Homo sapiens_hsa051401.57957798
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57159625
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56047550
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54171412
27Asthma_Homo sapiens_hsa053101.53792747
28Herpes simplex infection_Homo sapiens_hsa051681.50161938
29Retinol metabolism_Homo sapiens_hsa008301.48640913
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.46765717
31Fatty acid biosynthesis_Homo sapiens_hsa000611.45424222
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44286630
33Nitrogen metabolism_Homo sapiens_hsa009101.43552417
34Basal transcription factors_Homo sapiens_hsa030221.43379584
35Vitamin digestion and absorption_Homo sapiens_hsa049771.43267517
36Arachidonic acid metabolism_Homo sapiens_hsa005901.41418347
37RNA polymerase_Homo sapiens_hsa030201.40072703
38Butanoate metabolism_Homo sapiens_hsa006501.38296574
39ABC transporters_Homo sapiens_hsa020101.37948389
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37136868
41Nicotine addiction_Homo sapiens_hsa050331.36456688
42Taste transduction_Homo sapiens_hsa047421.36122368
43Oxidative phosphorylation_Homo sapiens_hsa001901.35570435
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35551789
45Homologous recombination_Homo sapiens_hsa034401.34363204
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.31038405
47Other glycan degradation_Homo sapiens_hsa005111.28371463
48Rheumatoid arthritis_Homo sapiens_hsa053231.24901901
49Malaria_Homo sapiens_hsa051441.18901813
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17534377
51Sphingolipid metabolism_Homo sapiens_hsa006001.16407312
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16128226
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14179749
54Influenza A_Homo sapiens_hsa051641.12663299
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11679726
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08713579
57Oocyte meiosis_Homo sapiens_hsa041141.07636151
58Caffeine metabolism_Homo sapiens_hsa002321.07603715
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07154492
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06544232
61Complement and coagulation cascades_Homo sapiens_hsa046101.01805821
62Parkinsons disease_Homo sapiens_hsa050121.01468335
63Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00193084
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99590241
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98997416
66Osteoclast differentiation_Homo sapiens_hsa043800.97595361
67Fatty acid elongation_Homo sapiens_hsa000620.96889489
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96427675
69Non-homologous end-joining_Homo sapiens_hsa034500.94854731
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.94717860
71Chemical carcinogenesis_Homo sapiens_hsa052040.94360160
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90383254
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88602152
74B cell receptor signaling pathway_Homo sapiens_hsa046620.88392613
75Base excision repair_Homo sapiens_hsa034100.88355782
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87946182
77Peroxisome_Homo sapiens_hsa041460.85867307
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85785286
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84435165
80Huntingtons disease_Homo sapiens_hsa050160.84393907
81Cell cycle_Homo sapiens_hsa041100.83971390
82Regulation of autophagy_Homo sapiens_hsa041400.82600425
83Pertussis_Homo sapiens_hsa051330.80684228
84Collecting duct acid secretion_Homo sapiens_hsa049660.78029123
85Tuberculosis_Homo sapiens_hsa051520.77760184
86Morphine addiction_Homo sapiens_hsa050320.77391309
87TNF signaling pathway_Homo sapiens_hsa046680.77325857
88African trypanosomiasis_Homo sapiens_hsa051430.76654786
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.76440955
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76150903
91Pyrimidine metabolism_Homo sapiens_hsa002400.74087995
92Legionellosis_Homo sapiens_hsa051340.73615949
93Sulfur relay system_Homo sapiens_hsa041220.72735504
94Histidine metabolism_Homo sapiens_hsa003400.72171146
95Chemokine signaling pathway_Homo sapiens_hsa040620.71876893
96Circadian entrainment_Homo sapiens_hsa047130.67686549
97Protein export_Homo sapiens_hsa030600.67124954
98Long-term depression_Homo sapiens_hsa047300.66204823
99Type I diabetes mellitus_Homo sapiens_hsa049400.65340614
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64479986
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.63716441
102Spliceosome_Homo sapiens_hsa030400.63584131
103Metabolic pathways_Homo sapiens_hsa011000.63011943
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.62891432
105Linoleic acid metabolism_Homo sapiens_hsa005910.62775182
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62719435
107Purine metabolism_Homo sapiens_hsa002300.61251182
108Toxoplasmosis_Homo sapiens_hsa051450.61207347
109Hepatitis C_Homo sapiens_hsa051600.59115902
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58745933
111Ovarian steroidogenesis_Homo sapiens_hsa049130.57756663
112beta-Alanine metabolism_Homo sapiens_hsa004100.56135110
113Calcium signaling pathway_Homo sapiens_hsa040200.55960361
114Apoptosis_Homo sapiens_hsa042100.55674066
115RNA degradation_Homo sapiens_hsa030180.54527525
116Vitamin B6 metabolism_Homo sapiens_hsa007500.50331819
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.49047290
118mRNA surveillance pathway_Homo sapiens_hsa030150.48650844
119Glutamatergic synapse_Homo sapiens_hsa047240.47678458
120Ether lipid metabolism_Homo sapiens_hsa005650.46914211
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46694414
122Salivary secretion_Homo sapiens_hsa049700.44792005
123p53 signaling pathway_Homo sapiens_hsa041150.44222484
124Antigen processing and presentation_Homo sapiens_hsa046120.44022376
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43478081
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43017767
127Starch and sucrose metabolism_Homo sapiens_hsa005000.42704857
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42175263
129Hepatitis B_Homo sapiens_hsa051610.42174486
130Serotonergic synapse_Homo sapiens_hsa047260.42004996
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41443152
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41178533
133Circadian rhythm_Homo sapiens_hsa047100.40298454
134T cell receptor signaling pathway_Homo sapiens_hsa046600.40142836
135Epstein-Barr virus infection_Homo sapiens_hsa051690.39726372
136Pyruvate metabolism_Homo sapiens_hsa006200.39131831
137Nucleotide excision repair_Homo sapiens_hsa034200.38614448
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37802713
139Tryptophan metabolism_Homo sapiens_hsa003800.37191322
140Acute myeloid leukemia_Homo sapiens_hsa052210.36739250
141Phagosome_Homo sapiens_hsa041450.36660497
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36368571
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36247598
144Fat digestion and absorption_Homo sapiens_hsa049750.33991502
145DNA replication_Homo sapiens_hsa030300.32870448
146One carbon pool by folate_Homo sapiens_hsa006700.32482230
147Arginine biosynthesis_Homo sapiens_hsa002200.31683883
148Fatty acid metabolism_Homo sapiens_hsa012120.30485273
149Ribosome_Homo sapiens_hsa030100.29710744
150GABAergic synapse_Homo sapiens_hsa047270.29341454
151Alzheimers disease_Homo sapiens_hsa050100.25168425

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