PRDX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.74380322
2aldehyde catabolic process (GO:0046185)5.63335517
3establishment of integrated proviral latency (GO:0075713)5.38481613
4hydrogen peroxide biosynthetic process (GO:0050665)5.08413080
5ribosome assembly (GO:0042255)4.73527946
6respiratory burst (GO:0045730)4.57716211
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.51786184
8positive regulation of interferon-alpha production (GO:0032727)4.49743674
9reactive oxygen species biosynthetic process (GO:1903409)4.45029395
10superoxide anion generation (GO:0042554)4.43801698
11establishment of viral latency (GO:0019043)4.29314949
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27429105
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.27223749
14negative regulation of ligase activity (GO:0051352)4.22059264
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.22059264
16regulation of interferon-alpha production (GO:0032647)4.20746960
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.15322527
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.13570583
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.93385087
20response to peptidoglycan (GO:0032494)3.93316143
21DNA strand elongation involved in DNA replication (GO:0006271)3.93096573
22formation of translation preinitiation complex (GO:0001731)3.92203994
23mitotic metaphase plate congression (GO:0007080)3.91087783
24granulocyte activation (GO:0036230)3.88722481
25regulation of cellular amino acid metabolic process (GO:0006521)3.87508850
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87271887
27nucleobase-containing small molecule interconversion (GO:0015949)3.78850645
28DNA strand elongation (GO:0022616)3.77884674
29CENP-A containing nucleosome assembly (GO:0034080)3.76862480
30eosinophil chemotaxis (GO:0048245)3.74350910
31purine nucleobase biosynthetic process (GO:0009113)3.72587188
32immunoglobulin mediated immune response (GO:0016064)3.71876942
33chromatin remodeling at centromere (GO:0031055)3.69717814
34chaperone-mediated protein transport (GO:0072321)3.69448948
35ribosomal large subunit biogenesis (GO:0042273)3.64255004
36IMP biosynthetic process (GO:0006188)3.63546283
37regulation of mitochondrial translation (GO:0070129)3.61872732
38telomere maintenance via semi-conservative replication (GO:0032201)3.60653135
39neutrophil activation (GO:0042119)3.56908549
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56600285
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.56600285
42modulation by symbiont of host immune response (GO:0052553)3.56600285
43positive regulation by symbiont of host defense response (GO:0052509)3.56600285
44modulation by symbiont of host defense response (GO:0052031)3.56600285
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56600285
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56504877
47regulation of activation of Janus kinase activity (GO:0010533)3.56174424
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54980879
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54980879
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54980879
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54978170
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54566375
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54566375
54positive regulation of chemokine biosynthetic process (GO:0045080)3.53059701
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.49804781
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.49804781
57protein complex localization (GO:0031503)3.48400136
58nucleobase biosynthetic process (GO:0046112)3.47610882
59protein localization to kinetochore (GO:0034501)3.44893138
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.44763099
61regulation of mononuclear cell migration (GO:0071675)3.44582505
62positive regulation of ligase activity (GO:0051351)3.44042731
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.41913549
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.40761253
65DNA replication checkpoint (GO:0000076)3.39268633
66ATP synthesis coupled proton transport (GO:0015986)3.38696709
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38696709
68rRNA modification (GO:0000154)3.37247716
69L-serine metabolic process (GO:0006563)3.35826120
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.34302177
71cellular response to interferon-alpha (GO:0035457)3.31829014
72spliceosomal snRNP assembly (GO:0000387)3.31635176
73regulation of ligase activity (GO:0051340)3.30898290
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30675280
75metaphase plate congression (GO:0051310)3.28818238
76ribosomal small subunit assembly (GO:0000028)3.27685097
77positive regulation of monocyte chemotaxis (GO:0090026)3.27499612
78lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27215054
79eosinophil migration (GO:0072677)3.26933032
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25131607
81IMP metabolic process (GO:0046040)3.22956778
82protein targeting to mitochondrion (GO:0006626)3.21287409
83maturation of SSU-rRNA (GO:0030490)3.21150734
84B cell mediated immunity (GO:0019724)3.20592753
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.18357040
86termination of RNA polymerase III transcription (GO:0006386)3.18357040
87DNA unwinding involved in DNA replication (GO:0006268)3.18128129
88production of molecular mediator involved in inflammatory response (GO:0002532)3.16574168
89protein localization to chromosome, centromeric region (GO:0071459)3.16137865
90cellular protein complex localization (GO:0034629)3.16130732
91monocyte chemotaxis (GO:0002548)3.15771014
92ribonucleoprotein complex biogenesis (GO:0022613)3.15445331
93tRNA aminoacylation for protein translation (GO:0006418)3.13977084
94cellular response to interferon-beta (GO:0035458)3.11429541
95negative regulation of myeloid cell apoptotic process (GO:0033033)3.11096622
96mitotic sister chromatid segregation (GO:0000070)3.10235992
97cell cycle G1/S phase transition (GO:0044843)3.10000565
98G1/S transition of mitotic cell cycle (GO:0000082)3.10000565
99ribosome biogenesis (GO:0042254)3.09812427
100amino acid activation (GO:0043038)3.08122454
101tRNA aminoacylation (GO:0043039)3.08122454
102histone exchange (GO:0043486)3.05261215
103ribosomal small subunit biogenesis (GO:0042274)3.04145018
104response to interferon-beta (GO:0035456)3.03719095
105positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.03399499
106pseudouridine synthesis (GO:0001522)3.03383986
107L-ascorbic acid metabolic process (GO:0019852)3.02939954
108regulation of chemokine biosynthetic process (GO:0045073)3.02436762
109telomere maintenance via recombination (GO:0000722)3.02302594
110T-helper 1 type immune response (GO:0042088)3.01986159
111rRNA processing (GO:0006364)3.00904385
112positive regulation of interferon-beta production (GO:0032728)3.00476141
113oxidative phosphorylation (GO:0006119)3.00009790
114DNA replication-independent nucleosome assembly (GO:0006336)2.99508099
115DNA replication-independent nucleosome organization (GO:0034724)2.99508099
116translation (GO:0006412)2.99328703
117nuclear pore complex assembly (GO:0051292)2.98189004
118low-density lipoprotein particle clearance (GO:0034383)2.97817120
119regulation of translational fidelity (GO:0006450)2.97328095
120mitochondrial RNA metabolic process (GO:0000959)2.97229650
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.97212567
122folic acid-containing compound biosynthetic process (GO:0009396)2.94311968
123establishment of protein localization to mitochondrion (GO:0072655)2.94073249
124protein localization to mitochondrion (GO:0070585)2.93853107
125tricarboxylic acid cycle (GO:0006099)2.93803742
126negative regulation of protein ubiquitination (GO:0031397)2.93256389
127mitotic recombination (GO:0006312)2.93203035
128positive regulation of type 2 immune response (GO:0002830)2.92384458
129mitotic nuclear envelope disassembly (GO:0007077)2.92037707
130negative regulation of viral genome replication (GO:0045071)2.90847324
131non-recombinational repair (GO:0000726)2.90507113
132double-strand break repair via nonhomologous end joining (GO:0006303)2.90507113
133type I interferon signaling pathway (GO:0060337)2.90069760
134cellular response to type I interferon (GO:0071357)2.90069760
135regulation of cellular amine metabolic process (GO:0033238)2.90043796
136maturation of 5.8S rRNA (GO:0000460)2.89186820
137regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.88361331
138protein maturation by protein folding (GO:0022417)2.88260306
139positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85817444
140regulation of fever generation (GO:0031620)2.85383835
141response to type I interferon (GO:0034340)2.84983982
142wound healing, spreading of epidermal cells (GO:0035313)2.84843979
143rRNA metabolic process (GO:0016072)2.84732466
144spindle checkpoint (GO:0031577)2.84396381
145positive regulation of heat generation (GO:0031652)2.84386290
146negative regulation of chromosome segregation (GO:0051985)2.83499392
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.83393029
148negative regulation of sister chromatid segregation (GO:0033046)2.83393029
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83393029
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83393029
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83393029
152phagosome maturation (GO:0090382)2.81566912
153regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80151868
154cellular response to exogenous dsRNA (GO:0071360)2.79832614
155antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79773833
156positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77585671
157defense response to protozoan (GO:0042832)2.77494737
158response to interferon-alpha (GO:0035455)2.77028485
159protein neddylation (GO:0045116)2.75562782
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73473037
161positive regulation of cAMP-mediated signaling (GO:0043950)2.73356824
162regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.73151861
163positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.72386090
164lymphocyte chemotaxis (GO:0048247)2.67734638
165positive regulation of lymphocyte migration (GO:2000403)2.66946297
166regulation of interferon-gamma biosynthetic process (GO:0045072)2.66743876
167proteasome assembly (GO:0043248)2.66036076
168cellular response to zinc ion (GO:0071294)2.65962098
169myeloid cell activation involved in immune response (GO:0002275)2.60359833
170regulation of interferon-beta biosynthetic process (GO:0045357)2.59130755
171negative regulation by host of viral transcription (GO:0043922)2.58934845
172phagocytosis, recognition (GO:0006910)2.58438385
173macrophage activation involved in immune response (GO:0002281)2.57955980
174macrophage chemotaxis (GO:0048246)2.56572920
175positive regulation of interleukin-12 production (GO:0032735)2.55166530
176positive regulation of cellular amide metabolic process (GO:0034250)2.54629466
177uronic acid metabolic process (GO:0006063)2.52394356
178glucuronate metabolic process (GO:0019585)2.52394356
179cellular response to virus (GO:0098586)2.51133591
180positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.50961131
181regulation of immunoglobulin secretion (GO:0051023)2.50623917
182regulation of T-helper 1 cell differentiation (GO:0045625)2.50311071
183positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48632250
184positive regulation of interleukin-17 production (GO:0032740)2.48272039
185response to muramyl dipeptide (GO:0032495)2.46669140
186regulation of RIG-I signaling pathway (GO:0039535)2.46618988
187regulation of metalloenzyme activity (GO:0048552)2.45726940
188positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.45673561
189positive regulation of antigen processing and presentation (GO:0002579)2.43647091
190regulation of heterotypic cell-cell adhesion (GO:0034114)2.43524977
191positive regulation of actin filament depolymerization (GO:0030836)2.42522230
192regulation of monocyte chemotaxis (GO:0090025)2.41723922
193positive regulation of mast cell activation involved in immune response (GO:0033008)2.41575636
194positive regulation of mast cell degranulation (GO:0043306)2.41575636
195positive regulation of chemokine production (GO:0032722)2.41402192
196positive regulation of interleukin-6 production (GO:0032755)2.41296840
197* superoxide metabolic process (GO:0006801)2.40963786
198positive regulation of response to biotic stimulus (GO:0002833)2.39677941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.96056247
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.81515667
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.42221573
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44722804
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29096007
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.11897155
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.06450641
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.01757662
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86338039
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.82878285
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.71249878
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65897945
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59685016
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53274741
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45403693
16E2F7_22180533_ChIP-Seq_HELA_Human2.42833254
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42704364
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.37318084
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36884951
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.32972502
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.31123199
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30664524
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23546705
24* XRN2_22483619_ChIP-Seq_HELA_Human2.20658617
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.12271712
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02217354
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00656019
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.97489171
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95926364
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94315912
31* TTF2_22483619_ChIP-Seq_HELA_Human1.91170040
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89399610
33* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.87523351
34GABP_19822575_ChIP-Seq_HepG2_Human1.85753155
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84797350
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84000202
37FOXP3_21729870_ChIP-Seq_TREG_Human1.83375329
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80076149
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77432204
40ELK1_19687146_ChIP-ChIP_HELA_Human1.76434073
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74685217
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.73893787
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72378733
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69873055
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67606045
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67188794
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66593626
48* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64390131
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61144396
50ZNF263_19887448_ChIP-Seq_K562_Human1.61095739
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60768998
52SPI1_23547873_ChIP-Seq_NB4_Human1.59648640
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57182894
54* MYC_18555785_ChIP-Seq_MESCs_Mouse1.55311529
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51441669
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.49433779
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49343231
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44748555
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44321608
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39162127
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38948260
62* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38623541
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38507933
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38491128
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36442232
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36085579
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.35344289
68TFEB_21752829_ChIP-Seq_HELA_Human1.33838526
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.30493371
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30408091
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29489746
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28750364
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26907055
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.26851061
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26204418
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23771032
77* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21853931
78* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21853931
79* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21582976
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20785730
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20785730
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20785730
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.19403705
84KDM5A_27292631_Chip-Seq_BREAST_Human1.19230201
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19169775
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19079173
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16927933
88* DCP1A_22483619_ChIP-Seq_HELA_Human1.16266026
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14876829
90* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14438734
91* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14238269
92* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13717623
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13714807
94* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11187502
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10344656
96VDR_23849224_ChIP-Seq_CD4+_Human1.08892375
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08840060
98* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08622839
99AR_21909140_ChIP-Seq_LNCAP_Human1.08251989
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08194228
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06468820
102* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06109273
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06017462
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.05663626
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.05470714
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05207246
107* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05043898
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04652930
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04391569
110* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03285734
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03035101
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02799030
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02771325
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02589951
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02290628
116SOX2_20726797_ChIP-Seq_SW620_Human1.02018076
117LXR_22158963_ChIP-Seq_LIVER_Mouse1.01576876
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01492999
119* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00661941
120* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99885122
121* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99850377
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.99500604
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99252130
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98389220
125MYC_18940864_ChIP-ChIP_HL60_Human0.96928481
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96160374
127PU_27001747_Chip-Seq_BMDM_Mouse0.96019523
128* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95288433
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94716496
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94484756
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93618487
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93473834
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93002572
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92210433
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91633501
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.91413157
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90830331
138* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90761747
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90371553
140* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90009296
141* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89920834
142* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89792064
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89277104
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88298086
145E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87962162
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87905396
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87639311
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87238312
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86730892
150ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86538708
151GATA3_26560356_Chip-Seq_TH2_Human0.86347466
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85518324
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85113168
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84526568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.80739777
2MP0010094_abnormal_chromosome_stability3.98765976
3MP0003111_abnormal_nucleus_morphology3.80328465
4MP0003806_abnormal_nucleotide_metabolis3.67287985
5MP0001835_abnormal_antigen_presentation3.60955897
6MP0006082_CNS_inflammation3.58817356
7MP0009785_altered_susceptibility_to3.57121447
8MP0002148_abnormal_hypersensitivity_rea3.43742727
9MP0008058_abnormal_DNA_repair3.41965901
10* MP0003077_abnormal_cell_cycle3.20408256
11MP0003436_decreased_susceptibility_to3.17868072
12MP0008932_abnormal_embryonic_tissue3.13147744
13* MP0003186_abnormal_redox_activity3.04593371
14MP0003724_increased_susceptibility_to2.85626956
15MP0002419_abnormal_innate_immunity2.75579468
16MP0008007_abnormal_cellular_replicative2.70461634
17MP0005000_abnormal_immune_tolerance2.66121266
18MP0005025_abnormal_response_to2.60542992
19MP0005058_abnormal_lysosome_morphology2.56517570
20MP0003195_calcinosis2.52130730
21MP0001730_embryonic_growth_arrest2.33119339
22MP0001853_heart_inflammation2.24543458
23MP0003303_peritoneal_inflammation2.22706927
24MP0003890_abnormal_embryonic-extraembry2.13720976
25MP0009697_abnormal_copulation2.11862060
26MP0002452_abnormal_antigen_presenting2.01520877
27MP0003136_yellow_coat_color1.99059096
28MP0005387_immune_system_phenotype1.94710455
29MP0001790_abnormal_immune_system1.94710455
30MP0005671_abnormal_response_to1.92154616
31MP0009764_decreased_sensitivity_to1.90953590
32MP0010030_abnormal_orbit_morphology1.89336765
33MP0002723_abnormal_immune_serum1.88208157
34* MP0000350_abnormal_cell_proliferation1.82978775
35MP0003786_premature_aging1.77621879
36MP0006035_abnormal_mitochondrial_morpho1.73494320
37MP0001533_abnormal_skeleton_physiology1.73448933
38MP0001672_abnormal_embryogenesis/_devel1.70288524
39MP0005380_embryogenesis_phenotype1.70288524
40MP0005408_hypopigmentation1.65234669
41MP0002796_impaired_skin_barrier1.65214841
42MP0000343_altered_response_to1.64185696
43MP0001697_abnormal_embryo_size1.63696401
44* MP0003448_altered_tumor_morphology1.62750190
45MP0003950_abnormal_plasma_membrane1.62683885
46MP0008469_abnormal_protein_level1.61991398
47MP0001800_abnormal_humoral_immune1.61850599
48MP0006036_abnormal_mitochondrial_physio1.61698532
49MP0000685_abnormal_immune_system1.59608759
50MP0003690_abnormal_glial_cell1.58187521
51MP0001845_abnormal_inflammatory_respons1.58165846
52MP0002080_prenatal_lethality1.57188901
53MP0004510_myositis1.53599806
54* MP0001819_abnormal_immune_cell1.50950275
55MP0000358_abnormal_cell_content/1.50892086
56MP0005501_abnormal_skin_physiology1.47511397
57MP0005164_abnormal_response_to1.46307213
58MP0002277_abnormal_respiratory_mucosa1.46064659
59MP0009840_abnormal_foam_cell1.45815631
60* MP0002420_abnormal_adaptive_immunity1.45756750
61MP0004947_skin_inflammation1.45187930
62MP0002085_abnormal_embryonic_tissue1.44021742
63MP0004782_abnormal_surfactant_physiolog1.43999383
64MP0000858_altered_metastatic_potential1.43523455
65MP0000920_abnormal_myelination1.43326805
66MP0002084_abnormal_developmental_patter1.43245346
67MP0002405_respiratory_system_inflammati1.42987885
68MP0003984_embryonic_growth_retardation1.42029575
69MP0009672_abnormal_birth_weight1.40307016
70MP0005360_urolithiasis1.38516798
71MP0003075_altered_response_to1.38013254
72MP0009379_abnormal_foot_pigmentation1.37951242
73MP0002088_abnormal_embryonic_growth/wei1.37387351
74MP0003315_abnormal_perineum_morphology1.36617857
75MP0001293_anophthalmia1.35144370
76MP0005464_abnormal_platelet_physiology1.32785383
77MP0000537_abnormal_urethra_morphology1.30972002
78MP0002877_abnormal_melanocyte_morpholog1.30715166
79MP0003453_abnormal_keratinocyte_physiol1.27753899
80* MP0000313_abnormal_cell_death1.27522437
81MP0010155_abnormal_intestine_physiology1.26828935
82MP0002998_abnormal_bone_remodeling1.26208073
83MP0009763_increased_sensitivity_to1.25171241
84MP0005451_abnormal_body_composition1.25167752
85MP0000490_abnormal_crypts_of1.24163124
86MP0009333_abnormal_splenocyte_physiolog1.23895281
87MP0002139_abnormal_hepatobiliary_system1.23767946
88MP0005166_decreased_susceptibility_to1.20298200
89MP0010234_abnormal_vibrissa_follicle1.19807196
90MP0000372_irregular_coat_pigmentation1.18557432
91MP0005171_absent_coat_pigmentation1.18530976
92MP0000604_amyloidosis1.18201375
93MP0002086_abnormal_extraembryonic_tissu1.18003281
94MP0004233_abnormal_muscle_weight1.16552918
95MP0010352_gastrointestinal_tract_polyps1.12799441
96MP0002254_reproductive_system_inflammat1.09645135
97MP0003191_abnormal_cellular_cholesterol1.09478043
98MP0008438_abnormal_cutaneous_collagen1.07300861
99MP0003567_abnormal_fetal_cardiomyocyte1.06878169
100MP0008875_abnormal_xenobiotic_pharmacok1.06662792
101MP0008260_abnormal_autophagy1.05780959
102MP0003718_maternal_effect1.04213504
103MP0002111_abnormal_tail_morphology1.04199662
104MP0002006_tumorigenesis1.03970445
105MP0002697_abnormal_eye_size1.03874950
106MP0003937_abnormal_limbs/digits/tail_de1.03286204
107MP0002090_abnormal_vision1.03159411
108MP0010307_abnormal_tumor_latency1.01542527
109MP0001727_abnormal_embryo_implantation0.99618712
110MP0004264_abnormal_extraembryonic_tissu0.98898812
111MP0001851_eye_inflammation0.97041918
112MP0002332_abnormal_exercise_endurance0.96815989
113MP0006292_abnormal_olfactory_placode0.96655919
114* MP0000716_abnormal_immune_system0.95842262
115MP0002138_abnormal_hepatobiliary_system0.93824109
116MP0002295_abnormal_pulmonary_circulatio0.92874578
117MP0000647_abnormal_sebaceous_gland0.91412725
118MP0002938_white_spotting0.90818248
119MP0004272_abnormal_basement_membrane0.90758084
120MP0005395_other_phenotype0.90458597
121MP0005167_abnormal_blood-brain_barrier0.87941170
122MP0005332_abnormal_amino_acid0.87694269
123MP0003172_abnormal_lysosome_physiology0.87642283
124MP0003941_abnormal_skin_development0.86956007
125MP0002136_abnormal_kidney_physiology0.85370623
126MP0005390_skeleton_phenotype0.85173318
127MP0000627_abnormal_mammary_gland0.83236506
128MP0000579_abnormal_nail_morphology0.81674743
129MP0001764_abnormal_homeostasis0.81474718
130MP0008004_abnormal_stomach_pH0.81418715
131MP0005023_abnormal_wound_healing0.80143515
132MP0005310_abnormal_salivary_gland0.79553579
133MP0005083_abnormal_biliary_tract0.78982458
134MP0004019_abnormal_vitamin_homeostasis0.78534127
135MP0005330_cardiomyopathy0.77708382
136MP0001881_abnormal_mammary_gland0.77254144
137MP0001849_ear_inflammation0.77252674
138* MP0002429_abnormal_blood_cell0.77249745
139MP0005397_hematopoietic_system_phenotyp0.76734532
140MP0001545_abnormal_hematopoietic_system0.76734532
141MP0009643_abnormal_urine_homeostasis0.76578524
142MP0002233_abnormal_nose_morphology0.76452015
143MP0009765_abnormal_xenobiotic_induced0.76154688
144MP0005384_cellular_phenotype0.75669840
145MP0002210_abnormal_sex_determination0.75188951
146MP0003119_abnormal_digestive_system0.74764525
147MP0004185_abnormal_adipocyte_glucose0.73491727
148MP0005257_abnormal_intraocular_pressure0.72693338
149MP0003656_abnormal_erythrocyte_physiolo0.72347098
150MP0005584_abnormal_enzyme/coenzyme_acti0.70971445
151MP0008873_increased_physiological_sensi0.70635085
152MP0003566_abnormal_cell_adhesion0.70554801
153MP0009278_abnormal_bone_marrow0.70510584
154MP0001661_extended_life_span0.70505342
155MP0001542_abnormal_bone_strength0.69863417
156MP0001529_abnormal_vocalization0.69850386
157MP0003011_delayed_dark_adaptation0.69629781
158MP0000762_abnormal_tongue_morphology0.69059519
159MP0003693_abnormal_embryo_hatching0.68459126
160MP0002933_joint_inflammation0.67682527
161MP0008057_abnormal_DNA_replication0.67570988
162* MP0000689_abnormal_spleen_morphology0.67020922
163MP0001286_abnormal_eye_development0.67019528
164MP0001929_abnormal_gametogenesis0.64627306
165MP0003221_abnormal_cardiomyocyte_apopto0.64419619
166* MP0002019_abnormal_tumor_incidence0.64224174
167MP0001915_intracranial_hemorrhage0.63218929
168MP0003123_paternal_imprinting0.61680525
169MP0001145_abnormal_male_reproductive0.61515826
170MP0002092_abnormal_eye_morphology0.61424990
171MP0001216_abnormal_epidermal_layer0.60084187
172MP0004197_abnormal_fetal_growth/weight/0.59797257
173MP0005365_abnormal_bile_salt0.57552186

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.40438443
2Recurrent gram-negative bacterial infections (HP:0005420)6.12024067
3Recurrent abscess formation (HP:0002722)5.89265652
4Recurrent bacterial skin infections (HP:0005406)5.55434283
5Abnormality of macrophages (HP:0004311)5.21066860
6Vacuolated lymphocytes (HP:0001922)4.22553789
7Multiple enchondromatosis (HP:0005701)4.19652817
8Mediastinal lymphadenopathy (HP:0100721)3.91200117
9Acute necrotizing encephalopathy (HP:0006965)3.83587529
10Stomatitis (HP:0010280)3.76084206
11Acute encephalopathy (HP:0006846)3.70769966
12Hepatosplenomegaly (HP:0001433)3.65153367
13Abnormal mitochondria in muscle tissue (HP:0008316)3.64036541
14Axonal loss (HP:0003447)3.56476392
15Microvesicular hepatic steatosis (HP:0001414)3.50317035
16Recurrent skin infections (HP:0001581)3.44219515
17Systemic lupus erythematosus (HP:0002725)3.41023650
18Parakeratosis (HP:0001036)3.40231644
19Autoimmune thrombocytopenia (HP:0001973)3.34184740
20Prolonged neonatal jaundice (HP:0006579)3.33467672
21Gingivitis (HP:0000230)3.31814595
22Increased CSF lactate (HP:0002490)3.30789147
23Poor head control (HP:0002421)3.29069513
24Chronic obstructive pulmonary disease (HP:0006510)3.24937986
25Obstructive lung disease (HP:0006536)3.24937986
26Nausea (HP:0002018)3.13888839
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.13760204
28Increased IgM level (HP:0003496)3.12133050
29Abnormality of methionine metabolism (HP:0010901)3.10540977
30Mitochondrial inheritance (HP:0001427)3.09484637
31Cerebral edema (HP:0002181)3.07433488
32Reticulocytopenia (HP:0001896)3.01780788
33Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00644096
34Basal ganglia calcification (HP:0002135)3.00039160
35Increased cerebral lipofuscin (HP:0011813)2.97195749
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.96425850
37Elevated erythrocyte sedimentation rate (HP:0003565)2.89940758
38Progressive macrocephaly (HP:0004481)2.87700118
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83705634
40Rough bone trabeculation (HP:0100670)2.82330977
41Tetraparesis (HP:0002273)2.79178963
42Reduced antithrombin III activity (HP:0001976)2.77830764
43Hepatocellular necrosis (HP:0001404)2.77790776
44Increased serum lactate (HP:0002151)2.73583238
45Recurrent pneumonia (HP:0006532)2.70638178
46Urticaria (HP:0001025)2.68793710
47Sparse eyelashes (HP:0000653)2.68147141
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65008259
49Macrocytic anemia (HP:0001972)2.64459408
50Type I transferrin isoform profile (HP:0003642)2.64009322
51Prostate neoplasm (HP:0100787)2.62309063
52Chromsome breakage (HP:0040012)2.61069029
53Birth length less than 3rd percentile (HP:0003561)2.59887640
54Agnosia (HP:0010524)2.59822734
55Myocardial infarction (HP:0001658)2.57128796
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55366039
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55366039
58Abnormal hemoglobin (HP:0011902)2.54598307
59Lactic acidosis (HP:0003128)2.54296531
60Progressive muscle weakness (HP:0003323)2.53704641
61Degeneration of anterior horn cells (HP:0002398)2.52660544
62Abnormality of the anterior horn cell (HP:0006802)2.52660544
63Meckel diverticulum (HP:0002245)2.48978515
64Congenital ichthyosiform erythroderma (HP:0007431)2.45013573
65Hepatic necrosis (HP:0002605)2.43320443
66Recurrent fungal infections (HP:0002841)2.42949419
67Spastic diplegia (HP:0001264)2.41052098
68Abnormality of serum amino acid levels (HP:0003112)2.40958692
69Increased serum pyruvate (HP:0003542)2.40061890
70Abnormality of glycolysis (HP:0004366)2.40061890
71Abnormality of the preputium (HP:0100587)2.39977426
72Abnormality of the umbilical cord (HP:0010881)2.39095928
73Exercise intolerance (HP:0003546)2.38644294
74Oral leukoplakia (HP:0002745)2.36930738
75Respiratory difficulties (HP:0002880)2.36238197
76Vasculitis (HP:0002633)2.35987452
77Interstitial pulmonary disease (HP:0006530)2.35833089
78Abnormality of cells of the erythroid lineage (HP:0012130)2.34269956
79Abnormalities of placenta or umbilical cord (HP:0001194)2.33771192
80Stenosis of the external auditory canal (HP:0000402)2.33114897
81Abnormal trabecular bone morphology (HP:0100671)2.29085730
82Selective tooth agenesis (HP:0001592)2.28702562
83Abnormality of the ileum (HP:0001549)2.28575178
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28359546
85Abnormal umbilical cord blood vessels (HP:0011403)2.27220833
86Single umbilical artery (HP:0001195)2.27220833
87Abnormality of the fetal cardiovascular system (HP:0010948)2.27220833
88Facial cleft (HP:0002006)2.26733106
89Abnormal lung lobation (HP:0002101)2.26623377
90Respiratory failure (HP:0002878)2.26133460
91Thick nail (HP:0001805)2.25881845
92Increased intramyocellular lipid droplets (HP:0012240)2.25850569
93Leukodystrophy (HP:0002415)2.25053607
94Aplastic anemia (HP:0001915)2.22195343
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21961625
96Megaloblastic anemia (HP:0001889)2.20753268
97Abnormal number of erythroid precursors (HP:0012131)2.20408450
98Exertional dyspnea (HP:0002875)2.20325002
99Increased serum ferritin (HP:0003281)2.18709331
100Steatorrhea (HP:0002570)2.16466600
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15479799
102Ependymoma (HP:0002888)2.15160948
103Secondary amenorrhea (HP:0000869)2.14511988
104Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14362831
105Fused cervical vertebrae (HP:0002949)2.13720346
106Glomerulonephritis (HP:0000099)2.12588723
107Trismus (HP:0000211)2.11869076
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10793149
109Abnormality of alanine metabolism (HP:0010916)2.10793149
110Hyperalaninemia (HP:0003348)2.10793149
111Disinhibition (HP:0000734)2.09660579
112Lethargy (HP:0001254)2.08825151
113Recurrent lower respiratory tract infections (HP:0002783)2.08521519
114Abnormality of placental membranes (HP:0011409)2.08476169
115Amniotic constriction ring (HP:0009775)2.08476169
116Hypobetalipoproteinemia (HP:0003563)2.06668229
117Pathologic fracture (HP:0002756)2.06559010
118Autoimmune hemolytic anemia (HP:0001890)2.05751650
119Osteomyelitis (HP:0002754)2.05356503
120Abnormality of chromosome stability (HP:0003220)2.05087003
121Hydroxyprolinuria (HP:0003080)2.04981466
122Abnormality of proline metabolism (HP:0010907)2.04981466
123Cerebral hypomyelination (HP:0006808)2.04734471
124Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04054182
125Colon cancer (HP:0003003)2.03185130
126Purpura (HP:0000979)2.02448735
127Cleft eyelid (HP:0000625)2.01767345
128Vertebral compression fractures (HP:0002953)2.01154826
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00794986
130Abnormal protein N-linked glycosylation (HP:0012347)2.00794986
131Abnormal protein glycosylation (HP:0012346)2.00794986
132Abnormal glycosylation (HP:0012345)2.00794986
133Joint hemorrhage (HP:0005261)1.99610841
134Posterior subcapsular cataract (HP:0007787)1.98274691
135Gout (HP:0001997)1.97738619
136Increased hepatocellular lipid droplets (HP:0006565)1.97301477
137Cellulitis (HP:0100658)1.96556754
138Pustule (HP:0200039)1.96133736
139Renal Fanconi syndrome (HP:0001994)1.96058823
140Horseshoe kidney (HP:0000085)1.95879108
141Intrahepatic cholestasis (HP:0001406)1.95469556
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.93698155
143Abnormality of iron homeostasis (HP:0011031)1.92462841
144Premature loss of primary teeth (HP:0006323)1.92403919
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.90420187
146Osteolytic defects of the hand bones (HP:0009699)1.90420187
147CNS demyelination (HP:0007305)1.90357239
148Postnatal microcephaly (HP:0005484)1.90147284
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.89645276
150Neoplasm of the adrenal gland (HP:0100631)1.87998452
151Abnormality of glycolipid metabolism (HP:0010969)1.87860729
152Abnormality of liposaccharide metabolism (HP:0010968)1.87860729
153Abnormality of glycosphingolipid metabolism (HP:0004343)1.87860729
154Esophageal varix (HP:0002040)1.87840401
155Progressive external ophthalmoplegia (HP:0000590)1.87366412
156Hypergammaglobulinemia (HP:0010702)1.86349210
157Dysphonia (HP:0001618)1.85511553
158Lipid accumulation in hepatocytes (HP:0006561)1.85363265
159Hypokinesia (HP:0002375)1.84811728
160Recurrent viral infections (HP:0004429)1.84212010
161Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83895964
162Fat malabsorption (HP:0002630)1.83813971
163Segmental peripheral demyelination/remyelination (HP:0003481)1.83575825
164Cortical dysplasia (HP:0002539)1.82838177
165Bone pain (HP:0002653)1.82188303
166Pancytopenia (HP:0001876)1.81497863
167Absent radius (HP:0003974)1.81442267
168Hyperglycinemia (HP:0002154)1.81314249
169Leukocytosis (HP:0001974)1.80946991
170Increased muscle lipid content (HP:0009058)1.79979057
171Xanthomatosis (HP:0000991)1.79754391
172Death in infancy (HP:0001522)1.78983374
173Hyperglycinuria (HP:0003108)1.78402654
174Small intestinal stenosis (HP:0012848)1.76776141
175Duodenal stenosis (HP:0100867)1.76776141
176Orchitis (HP:0100796)1.76452039
177Abnormality of pyrimidine metabolism (HP:0004353)1.76170877
178Abnormal gallbladder physiology (HP:0012438)1.75955043
179Porencephaly (HP:0002132)1.72300075
180Gingival bleeding (HP:0000225)1.72248765
181Conjunctival telangiectasia (HP:0000524)1.71513216
182Abnormality of T cell number (HP:0011839)1.70792087
183Erythroderma (HP:0001019)1.70095109
184Neurofibrillary tangles (HP:0002185)1.69680302
185Anorexia (HP:0002039)1.69571184
186Abnormality of transition element cation homeostasis (HP:0011030)1.68359993
187Optic neuritis (HP:0100653)1.68307879
188Retrobulbar optic neuritis (HP:0100654)1.68307879
189Hypercholesterolemia (HP:0003124)1.68278089
190Prolonged partial thromboplastin time (HP:0003645)1.65797500
191Epidermoid cyst (HP:0200040)1.63921272
192Loss of speech (HP:0002371)1.63608836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.83072221
2MAP3K143.58457671
3TSSK63.54012302
4VRK23.51077601
5NEK13.40873784
6BLK3.34063271
7SRPK13.17625711
8TBK13.03923019
9NME22.92044330
10IRAK32.82422019
11RIPK42.78202027
12CDC72.73726630
13PDK22.65862560
14IRAK42.50991952
15STK162.36236152
16PIM22.35497452
17ABL22.33011788
18NME12.30385623
19MST1R2.19042534
20EIF2AK12.18525933
21TYK22.17704911
22STK392.07970063
23IKBKB2.06103327
24PLK32.04529600
25BUB11.92352730
26NEK91.85230716
27PAK41.84068180
28IKBKE1.81249448
29ERBB41.80448921
30TRIM281.77746886
31BCR1.72279470
32MET1.71147480
33MAP3K121.70511127
34TESK21.62151715
35PLK11.49125020
36RPS6KA41.48861808
37EPHB11.48017430
38TAF11.44302547
39SCYL21.38575904
40TESK11.37547999
41BRSK21.35180288
42JAK31.34861777
43BMPR21.26492280
44SMG11.24446304
45EIF2AK31.22908204
46BRSK11.16137016
47MKNK21.15445330
48LIMK11.14858881
49AURKB1.12639985
50EIF2AK21.10845608
51CHEK21.09015513
52* PBK1.08531239
53ACVR1B1.08265633
54TXK1.06011308
55TRPM71.03628701
56BMX1.02844115
57MARK31.02602917
58LATS21.02529913
59PLK41.02383396
60PIM11.00408710
61CHUK0.98763243
62ARAF0.97910470
63LYN0.97029969
64FGR0.96496741
65CSK0.95951524
66STK100.95062903
67ALK0.94607115
68MAP3K130.92516170
69IRAK10.92035617
70KIT0.91491518
71OXSR10.91003702
72RPS6KB20.87963180
73TLK10.86186487
74JAK10.85421558
75CDK70.85238478
76EPHA20.85130777
77BMPR1B0.85065135
78ATR0.84502952
79YES10.83944796
80TNIK0.82716125
81WEE10.79429582
82WNK40.78967724
83AURKA0.78861079
84MAP3K110.74816329
85CLK10.73733160
86RPS6KA50.73579678
87CHEK10.73084335
88ERBB30.72901272
89IRAK20.72817798
90LMTK20.70402432
91ZAK0.69366227
92ABL10.69305532
93DAPK10.67133941
94PRKCD0.65403105
95NEK20.64344308
96ILK0.63427317
97MKNK10.62885841
98MATK0.62774989
99MAP3K30.62643307
100GRK70.61696927
101CDK60.61146740
102CSNK2A20.60252466
103KDR0.59871614
104MAP3K50.59723449
105STK30.58871283
106PNCK0.58232912
107MAP3K80.58173160
108EGFR0.56579883
109ADRBK20.55732255
110FGFR10.55408223
111* LCK0.54704734
112MOS0.53547407
113DYRK20.53185733
114EPHA30.52676016
115VRK10.52341307
116DAPK30.51455949
117NLK0.48939468
118NEK60.48326266
119AKT20.48215287
120ATM0.48196985
121NUAK10.48073633
122PRKCQ0.48028512
123BCKDK0.47993850
124BRAF0.47792447
125PRKCI0.46977198
126PKN10.46773500
127JAK20.46098302
128LRRK20.46052871
129CDK80.45866689
130MAPKAPK50.45856412
131TTK0.45128394
132HCK0.43101193
133FGFR40.42625506
134CSNK2A10.41861032
135DYRK30.41613413
136CSNK1E0.41150800
137PASK0.41111688
138CSNK1G10.40779837
139SYK0.39968787
140ERN10.39740565
141MAP4K10.39485827
142CCNB10.38490086
143PAK10.37762641
144CSNK1G30.37640279
145MYLK0.37582664
146ZAP700.36756965
147MELK0.36664173
148PRKG20.36421917
149* CDK10.35182321
150MAP2K20.34579972
151TAOK20.34040944
152STK38L0.32613287
153CDK20.31125926
154CDK90.29749083
155CDK40.29364439
156PAK20.24308366
157CAMK2G0.23820836
158CSNK1A1L0.23712925
159LATS10.23504605

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.36548897
2Graft-versus-host disease_Homo sapiens_hsa053322.91869320
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.91157967
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.72608650
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57230095
6Steroid biosynthesis_Homo sapiens_hsa001002.53419483
7Staphylococcus aureus infection_Homo sapiens_hsa051502.37213319
8Spliceosome_Homo sapiens_hsa030402.18385342
9Allograft rejection_Homo sapiens_hsa053302.16531635
10Legionellosis_Homo sapiens_hsa051342.13113077
11Leishmaniasis_Homo sapiens_hsa051402.11350350
12Rheumatoid arthritis_Homo sapiens_hsa053232.07028195
13Non-homologous end-joining_Homo sapiens_hsa034502.04326030
14RNA transport_Homo sapiens_hsa030132.01668349
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96700246
16Base excision repair_Homo sapiens_hsa034101.95236994
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92653430
18Pyruvate metabolism_Homo sapiens_hsa006201.82000313
19Malaria_Homo sapiens_hsa051441.81322200
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75851601
21Biosynthesis of amino acids_Homo sapiens_hsa012301.75072307
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.71150285
23Vitamin B6 metabolism_Homo sapiens_hsa007501.69073227
24Pertussis_Homo sapiens_hsa051331.68126342
25Carbon metabolism_Homo sapiens_hsa012001.67191621
26Phagosome_Homo sapiens_hsa041451.65416545
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61761207
28Asthma_Homo sapiens_hsa053101.61623294
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60528346
30Cell cycle_Homo sapiens_hsa041101.55857801
31Oxidative phosphorylation_Homo sapiens_hsa001901.50722551
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44753499
33Type I diabetes mellitus_Homo sapiens_hsa049401.43807372
34Glutathione metabolism_Homo sapiens_hsa004801.43387945
35Lysosome_Homo sapiens_hsa041421.42690518
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42669734
37Protein export_Homo sapiens_hsa030601.38119181
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37477579
39Tuberculosis_Homo sapiens_hsa051521.36379609
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33632705
41Basal transcription factors_Homo sapiens_hsa030221.29682775
42Histidine metabolism_Homo sapiens_hsa003401.28086508
43Salmonella infection_Homo sapiens_hsa051321.26657657
44Measles_Homo sapiens_hsa051621.20694625
45RNA degradation_Homo sapiens_hsa030181.19829330
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19359504
47Ribosome_Homo sapiens_hsa030101.16836188
48Autoimmune thyroid disease_Homo sapiens_hsa053201.16644551
49Fanconi anemia pathway_Homo sapiens_hsa034601.15649318
50RNA polymerase_Homo sapiens_hsa030201.13461938
51Propanoate metabolism_Homo sapiens_hsa006401.13342155
52Folate biosynthesis_Homo sapiens_hsa007901.11625927
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11478658
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11408194
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10633993
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10163617
57Influenza A_Homo sapiens_hsa051641.10111228
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10005721
59One carbon pool by folate_Homo sapiens_hsa006701.07722337
60Purine metabolism_Homo sapiens_hsa002301.07577480
61Chemical carcinogenesis_Homo sapiens_hsa052041.07502082
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.07258238
63Complement and coagulation cascades_Homo sapiens_hsa046101.06839004
64TNF signaling pathway_Homo sapiens_hsa046681.05801708
65Osteoclast differentiation_Homo sapiens_hsa043801.03977711
66Herpes simplex infection_Homo sapiens_hsa051681.03336233
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02099180
68Collecting duct acid secretion_Homo sapiens_hsa049661.01152737
69Fatty acid elongation_Homo sapiens_hsa000621.00563454
70African trypanosomiasis_Homo sapiens_hsa051430.98496421
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98368844
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97439189
73Mineral absorption_Homo sapiens_hsa049780.93159966
74Parkinsons disease_Homo sapiens_hsa050120.93000247
75Galactose metabolism_Homo sapiens_hsa000520.92805280
76Mismatch repair_Homo sapiens_hsa034300.91927757
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91149257
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88512711
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88437527
80mRNA surveillance pathway_Homo sapiens_hsa030150.86954612
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86836408
82Sulfur relay system_Homo sapiens_hsa041220.84499240
83Pyrimidine metabolism_Homo sapiens_hsa002400.83778857
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82610286
85Fructose and mannose metabolism_Homo sapiens_hsa000510.81624823
86DNA replication_Homo sapiens_hsa030300.81082340
87Homologous recombination_Homo sapiens_hsa034400.80907125
88Hematopoietic cell lineage_Homo sapiens_hsa046400.79001490
89Apoptosis_Homo sapiens_hsa042100.76739545
90Ether lipid metabolism_Homo sapiens_hsa005650.75382173
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75216245
92Metabolic pathways_Homo sapiens_hsa011000.75005241
93Sulfur metabolism_Homo sapiens_hsa009200.74746984
94* Peroxisome_Homo sapiens_hsa041460.74119444
95N-Glycan biosynthesis_Homo sapiens_hsa005100.74021132
96Shigellosis_Homo sapiens_hsa051310.72694405
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.72328391
98Vitamin digestion and absorption_Homo sapiens_hsa049770.71941154
99Antigen processing and presentation_Homo sapiens_hsa046120.71923554
100Fatty acid degradation_Homo sapiens_hsa000710.69049852
101Retinol metabolism_Homo sapiens_hsa008300.67049501
102Prion diseases_Homo sapiens_hsa050200.64482769
103Arginine and proline metabolism_Homo sapiens_hsa003300.64288902
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.62918364
105p53 signaling pathway_Homo sapiens_hsa041150.62584827
106Phenylalanine metabolism_Homo sapiens_hsa003600.61365263
107Arachidonic acid metabolism_Homo sapiens_hsa005900.61190917
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60941050
109Epstein-Barr virus infection_Homo sapiens_hsa051690.60754358
110Fatty acid metabolism_Homo sapiens_hsa012120.60638678
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.60391837
112Huntingtons disease_Homo sapiens_hsa050160.60088997
113Other glycan degradation_Homo sapiens_hsa005110.58690125
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56927555
115Vibrio cholerae infection_Homo sapiens_hsa051100.56259299
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55655820
117Tyrosine metabolism_Homo sapiens_hsa003500.55601417
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55305730
119Toxoplasmosis_Homo sapiens_hsa051450.54952711
120Pentose phosphate pathway_Homo sapiens_hsa000300.54495260
121beta-Alanine metabolism_Homo sapiens_hsa004100.54414677
122Hepatitis C_Homo sapiens_hsa051600.53437338
123Alzheimers disease_Homo sapiens_hsa050100.52671385
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52025870
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51222107
126Chemokine signaling pathway_Homo sapiens_hsa040620.48607661
127Nucleotide excision repair_Homo sapiens_hsa034200.48319408
128Viral myocarditis_Homo sapiens_hsa054160.48260025
129Selenocompound metabolism_Homo sapiens_hsa004500.48052239
130Arginine biosynthesis_Homo sapiens_hsa002200.47180586
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45749167
132Sphingolipid metabolism_Homo sapiens_hsa006000.45611196
133Caffeine metabolism_Homo sapiens_hsa002320.44429579
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.44235721
135Oocyte meiosis_Homo sapiens_hsa041140.42780106
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.42679653
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.42602731
138Cardiac muscle contraction_Homo sapiens_hsa042600.41786880
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.36632054
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33103532
141Thyroid cancer_Homo sapiens_hsa052160.32100396
142Tryptophan metabolism_Homo sapiens_hsa003800.30978071
143Fat digestion and absorption_Homo sapiens_hsa049750.28372574
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23739093
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22930864
146TGF-beta signaling pathway_Homo sapiens_hsa043500.21637592
147Tight junction_Homo sapiens_hsa045300.20541770
148Starch and sucrose metabolism_Homo sapiens_hsa005000.20243919
149Systemic lupus erythematosus_Homo sapiens_hsa053220.20199367

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