PRDX1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.40952673
2DNA deamination (GO:0045006)6.04359881
3protein neddylation (GO:0045116)5.48300871
4proteasome assembly (GO:0043248)5.28164955
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.98305753
6water-soluble vitamin biosynthetic process (GO:0042364)4.92099416
7ribosome assembly (GO:0042255)4.88856848
8mitochondrial RNA metabolic process (GO:0000959)4.57075938
9transcription from mitochondrial promoter (GO:0006390)4.56904764
10DNA methylation involved in gamete generation (GO:0043046)4.50542197
11rRNA modification (GO:0000154)4.40227269
12maturation of 5.8S rRNA (GO:0000460)4.24262302
13peptidyl-histidine modification (GO:0018202)4.07797708
14resolution of meiotic recombination intermediates (GO:0000712)3.98839571
15rRNA methylation (GO:0031167)3.96001320
16chaperone-mediated protein transport (GO:0072321)3.95845045
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78574508
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.73820024
19pseudouridine synthesis (GO:0001522)3.68766450
20respiratory chain complex IV assembly (GO:0008535)3.65999837
21protein complex biogenesis (GO:0070271)3.64322099
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64258286
23cullin deneddylation (GO:0010388)3.63619242
24cytochrome complex assembly (GO:0017004)3.61097223
25mitochondrial respiratory chain complex assembly (GO:0033108)3.60392546
26protein deneddylation (GO:0000338)3.58735112
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58326784
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57524132
29kinetochore assembly (GO:0051382)3.57451690
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54369913
31negative regulation of ligase activity (GO:0051352)3.54369913
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.46953740
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.46953740
34isotype switching (GO:0045190)3.46953740
35regulation of cellular amino acid metabolic process (GO:0006521)3.45152331
36DNA catabolic process, exonucleolytic (GO:0000738)3.44279758
37DNA double-strand break processing (GO:0000729)3.43144892
38regulation of chronic inflammatory response (GO:0002676)3.38535663
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37647739
40chromatin remodeling at centromere (GO:0031055)3.36551436
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33918205
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32897120
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32897120
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32897120
45CENP-A containing nucleosome assembly (GO:0034080)3.31746412
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28840028
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28840028
48meiotic chromosome segregation (GO:0045132)3.27834203
49tRNA aminoacylation for protein translation (GO:0006418)3.22694019
50lactate metabolic process (GO:0006089)3.21878172
51tRNA aminoacylation (GO:0043039)3.21117220
52amino acid activation (GO:0043038)3.21117220
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20708026
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.20429719
55NADH dehydrogenase complex assembly (GO:0010257)3.20429719
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20429719
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19212900
58signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16602946
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.16602946
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.15335654
61kinetochore organization (GO:0051383)3.14279692
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13097474
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13097474
64histone exchange (GO:0043486)3.09946168
65positive regulation of ligase activity (GO:0051351)3.09504354
66double-strand break repair via nonhomologous end joining (GO:0006303)3.08972978
67non-recombinational repair (GO:0000726)3.08972978
68protein-cofactor linkage (GO:0018065)3.04992929
69replication fork processing (GO:0031297)3.03969406
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03500608
71ATP synthesis coupled proton transport (GO:0015986)3.03500608
72transcription elongation from RNA polymerase I promoter (GO:0006362)3.02678898
73mitochondrial DNA replication (GO:0006264)3.02202529
74termination of RNA polymerase I transcription (GO:0006363)3.00584600
75rRNA processing (GO:0006364)3.00212721
76synapsis (GO:0007129)2.96936940
77tRNA metabolic process (GO:0006399)2.96305888
78ribosomal large subunit biogenesis (GO:0042273)2.96184453
79intracellular protein transmembrane import (GO:0044743)2.95928396
80folic acid-containing compound biosynthetic process (GO:0009396)2.95568723
81rRNA metabolic process (GO:0016072)2.95166435
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94885344
83mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94025439
84regulation of ubiquitin-protein transferase activity (GO:0051438)2.93440746
85protein targeting to mitochondrion (GO:0006626)2.93374897
86regulation of ligase activity (GO:0051340)2.86388251
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83523879
88ncRNA metabolic process (GO:0034660)2.82616631
89somatic recombination of immunoglobulin gene segments (GO:0016447)2.82615429
90regulation of immunoglobulin secretion (GO:0051023)2.81289462
91establishment of protein localization to mitochondrion (GO:0072655)2.81115829
92IMP biosynthetic process (GO:0006188)2.80591827
93tRNA processing (GO:0008033)2.80478765
94positive regulation of isotype switching (GO:0045830)2.79144005
95nucleobase biosynthetic process (GO:0046112)2.76937636
96protein localization to mitochondrion (GO:0070585)2.76797944
97ribosomal small subunit assembly (GO:0000028)2.76778940
98male meiosis (GO:0007140)2.73716523
99oxidative phosphorylation (GO:0006119)2.73654640
100somatic diversification of immunoglobulins (GO:0016445)2.73020806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.16771111
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.64129249
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.89957669
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43014290
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.37482940
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32817131
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20911186
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99661332
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.91266532
10VDR_23849224_ChIP-Seq_CD4+_Human2.70533977
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67649052
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66282801
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56532589
14FOXP3_21729870_ChIP-Seq_TREG_Human2.46069483
15ELK1_19687146_ChIP-ChIP_HELA_Human2.44717713
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41850427
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40090629
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35971309
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.30295963
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30152893
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23024206
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22211496
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17786951
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10557718
25ZNF274_21170338_ChIP-Seq_K562_Hela2.02987539
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02911583
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.97552208
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.93775460
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93617521
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92692744
31MYC_18940864_ChIP-ChIP_HL60_Human1.91662033
32E2F7_22180533_ChIP-Seq_HELA_Human1.91261730
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90979217
34DCP1A_22483619_ChIP-Seq_HELA_Human1.88242409
35VDR_22108803_ChIP-Seq_LS180_Human1.82780151
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76320578
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75712038
38TTF2_22483619_ChIP-Seq_HELA_Human1.69641097
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65384161
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64537394
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64231891
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62671835
43EWS_26573619_Chip-Seq_HEK293_Human1.62589595
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60677325
45GABP_19822575_ChIP-Seq_HepG2_Human1.57611862
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56895268
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53224408
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48931710
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48325871
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46285490
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45564188
52TP53_22573176_ChIP-Seq_HFKS_Human1.44322586
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43319442
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.42017013
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36838197
56FUS_26573619_Chip-Seq_HEK293_Human1.26273657
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25134549
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23867928
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21448312
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.19478595
61XRN2_22483619_ChIP-Seq_HELA_Human1.15465530
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11615875
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11256799
64LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10752195
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08178348
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06215429
67ELF5_23300383_ChIP-Seq_T47D_Human1.05141725
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02833712
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.02833712
70SALL4_22934838_ChIP-ChIP_CD34+_Human1.00933002
71NANOG_16153702_ChIP-ChIP_HESCs_Human0.99257697
72NANOG_19829295_ChIP-Seq_ESCs_Human0.97474593
73SOX2_19829295_ChIP-Seq_ESCs_Human0.97474593
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97286270
75NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94607351
76HOXB7_26014856_ChIP-Seq_BT474_Human0.94282092
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92316416
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91542998
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.91494964
80P300_19829295_ChIP-Seq_ESCs_Human0.89614532
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88730146
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88420568
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87110181
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.86744160
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85526095
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85069771
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.82633811
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.81940055
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80515147
90AR_21909140_ChIP-Seq_LNCAP_Human0.78431216
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78024445
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78024445
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78024445
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77680870
95AR_20517297_ChIP-Seq_VCAP_Human0.77061751
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76764287
97HTT_18923047_ChIP-ChIP_STHdh_Human0.76728157
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76531271
99ER_23166858_ChIP-Seq_MCF-7_Human0.75897150
100GATA3_26560356_Chip-Seq_TH2_Human0.75859116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.33482226
2MP0008875_abnormal_xenobiotic_pharmacok3.92296067
3MP0003646_muscle_fatigue3.71041419
4MP0008058_abnormal_DNA_repair3.35468926
5MP0008877_abnormal_DNA_methylation3.31084066
6MP0003186_abnormal_redox_activity3.08754855
7MP0008872_abnormal_physiological_respon2.99124878
8MP0003693_abnormal_embryo_hatching2.89436772
9MP0002837_dystrophic_cardiac_calcinosis2.74618517
10MP0008775_abnormal_heart_ventricle2.70322632
11MP0003567_abnormal_fetal_cardiomyocyte2.54606015
12MP0004957_abnormal_blastocyst_morpholog2.42914448
13MP0005084_abnormal_gallbladder_morpholo2.37863461
14MP0002254_reproductive_system_inflammat2.19072948
15MP0006292_abnormal_olfactory_placode2.18356992
16MP0001873_stomach_inflammation2.17841177
17MP0010094_abnormal_chromosome_stability2.11975701
18MP0008007_abnormal_cellular_replicative1.88877388
19MP0002160_abnormal_reproductive_system1.84637137
20MP0009697_abnormal_copulation1.83578562
21MP0004145_abnormal_muscle_electrophysio1.79609173
22MP0002736_abnormal_nociception_after1.79170157
23MP0001348_abnormal_lacrimal_gland1.76309713
24MP0003786_premature_aging1.63632891
25MP0003806_abnormal_nucleotide_metabolis1.63396437
26MP0001984_abnormal_olfaction1.61845950
27MP0006054_spinal_hemorrhage1.61363765
28MP0001835_abnormal_antigen_presentation1.59231029
29MP0002138_abnormal_hepatobiliary_system1.57997195
30MP0003950_abnormal_plasma_membrane1.56060788
31MP0008932_abnormal_embryonic_tissue1.54609402
32MP0008789_abnormal_olfactory_epithelium1.54561279
33MP0002210_abnormal_sex_determination1.50052139
34MP0005389_reproductive_system_phenotype1.48672877
35MP0005395_other_phenotype1.44982729
36MP0006036_abnormal_mitochondrial_physio1.43740696
37MP0001929_abnormal_gametogenesis1.37398892
38MP0006072_abnormal_retinal_apoptosis1.36643337
39MP0000372_irregular_coat_pigmentation1.35216522
40MP0003077_abnormal_cell_cycle1.31921265
41MP0001968_abnormal_touch/_nociception1.30142194
42MP0005646_abnormal_pituitary_gland1.25340289
43MP0005075_abnormal_melanosome_morpholog1.16826937
44MP0000653_abnormal_sex_gland1.16414711
45MP0001188_hyperpigmentation1.16218804
46MP0005410_abnormal_fertilization1.16020097
47MP0009765_abnormal_xenobiotic_induced1.15956744
48MP0006035_abnormal_mitochondrial_morpho1.14493232
49MP0000427_abnormal_hair_cycle1.11110762
50MP0001119_abnormal_female_reproductive1.09564378
51MP0004084_abnormal_cardiac_muscle1.09185767
52MP0004215_abnormal_myocardial_fiber1.09049217
53MP0002876_abnormal_thyroid_physiology1.08119577
54MP0001145_abnormal_male_reproductive1.07577908
55MP0001666_abnormal_nutrient_absorption1.06084274
56MP0003111_abnormal_nucleus_morphology1.04537825
57MP0002751_abnormal_autonomic_nervous1.04487528
58MP0002102_abnormal_ear_morphology1.03267420
59MP0009780_abnormal_chondrocyte_physiolo1.02872762
60MP0002928_abnormal_bile_duct1.02072370
61MP0004782_abnormal_surfactant_physiolog0.99751625
62MP0005332_abnormal_amino_acid0.98223255
63MP0003937_abnormal_limbs/digits/tail_de0.94769073
64MP0006082_CNS_inflammation0.94526816
65MP0001853_heart_inflammation0.93083093
66MP0001485_abnormal_pinna_reflex0.91735752
67MP0002277_abnormal_respiratory_mucosa0.90037500
68MP0005083_abnormal_biliary_tract0.86700881
69MP0001730_embryonic_growth_arrest0.86311017
70MP0003011_delayed_dark_adaptation0.85104667
71MP0005319_abnormal_enzyme/_coenzyme0.82413245
72MP0000490_abnormal_crypts_of0.81204832
73MP0004142_abnormal_muscle_tone0.80921774
74MP0003698_abnormal_male_reproductive0.78802698
75MP0001919_abnormal_reproductive_system0.78559880
76MP0001661_extended_life_span0.77129919
77MP0003890_abnormal_embryonic-extraembry0.76696786
78MP0005551_abnormal_eye_electrophysiolog0.75295316
79MP0003936_abnormal_reproductive_system0.73886735
80MP0001905_abnormal_dopamine_level0.73603576
81MP0001529_abnormal_vocalization0.72708368
82MP0002084_abnormal_developmental_patter0.72534522
83MP0008057_abnormal_DNA_replication0.71987808
84MP0000313_abnormal_cell_death0.70386914
85MP0001764_abnormal_homeostasis0.70087197
86MP0001881_abnormal_mammary_gland0.68641916
87MP0008873_increased_physiological_sensi0.68134362
88MP0003252_abnormal_bile_duct0.67806224
89MP0002148_abnormal_hypersensitivity_rea0.66465004
90MP0002006_tumorigenesis0.64938307
91MP0001697_abnormal_embryo_size0.64532883
92MP0000358_abnormal_cell_content/0.63218504
93MP0004133_heterotaxia0.62604136
94MP0009250_abnormal_appendicular_skeleto0.62407695
95MP0005636_abnormal_mineral_homeostasis0.62329277
96MP0009764_decreased_sensitivity_to0.62066232
97MP0005499_abnormal_olfactory_system0.61833594
98MP0005394_taste/olfaction_phenotype0.61833594
99MP0005380_embryogenesis_phenotype0.61243734
100MP0001672_abnormal_embryogenesis/_devel0.61243734

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.90730265
23-Methylglutaconic aciduria (HP:0003535)3.77589799
3Abnormality of the labia minora (HP:0012880)3.74342095
4Progressive macrocephaly (HP:0004481)3.63396025
5Methylmalonic acidemia (HP:0002912)3.60572953
6Acute encephalopathy (HP:0006846)3.58189929
7Increased CSF lactate (HP:0002490)3.50884326
8Mitochondrial inheritance (HP:0001427)3.49277102
9Methylmalonic aciduria (HP:0012120)3.36490276
10Increased serum lactate (HP:0002151)3.34757789
11Hepatocellular necrosis (HP:0001404)3.26022376
12Abnormal mitochondria in muscle tissue (HP:0008316)3.21626351
13Hepatic necrosis (HP:0002605)2.99259706
14Cutaneous melanoma (HP:0012056)2.95513108
15Increased hepatocellular lipid droplets (HP:0006565)2.94413372
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92896511
17Hyperglycinemia (HP:0002154)2.90951358
18Hypoplasia of the uterus (HP:0000013)2.86587226
19Colon cancer (HP:0003003)2.82782012
20Aplasia/hypoplasia of the uterus (HP:0008684)2.81466285
21Fibular aplasia (HP:0002990)2.78711814
22Abnormality of alanine metabolism (HP:0010916)2.75323562
23Hyperalaninemia (HP:0003348)2.75323562
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75323562
25Lipid accumulation in hepatocytes (HP:0006561)2.70197538
26Gonadotropin excess (HP:0000837)2.68962372
27Abnormality of the pons (HP:0007361)2.67831159
28Chromsome breakage (HP:0040012)2.65754684
29Cerebral edema (HP:0002181)2.63501099
30Pancreatic cysts (HP:0001737)2.59499632
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54811920
32Adactyly (HP:0009776)2.54755613
33Duplicated collecting system (HP:0000081)2.48158997
34Lethargy (HP:0001254)2.44204744
35Lactic acidosis (HP:0003128)2.40773256
36Abnormality of the renal collecting system (HP:0004742)2.38292893
37Cerebral hypomyelination (HP:0006808)2.34830990
38Meckel diverticulum (HP:0002245)2.34669626
39Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.34460744
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34094582
41CNS demyelination (HP:0007305)2.32003178
42Pancytopenia (HP:0001876)2.30736715
43Carpal bone hypoplasia (HP:0001498)2.29452541
44Abnormality of glycine metabolism (HP:0010895)2.28702640
45Abnormality of serine family amino acid metabolism (HP:0010894)2.28702640
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26829587
47Absent thumb (HP:0009777)2.26481684
48Abnormality of the ileum (HP:0001549)2.23325708
49Abnormality of serum amino acid levels (HP:0003112)2.23033622
50Tubulointerstitial nephritis (HP:0001970)2.20861769
51Meningioma (HP:0002858)2.20671707
52Abnormality of the vitamin B12 metabolism (HP:0004341)2.18073739
53Respiratory failure (HP:0002878)2.14892303
54Exercise intolerance (HP:0003546)2.14191839
55Degeneration of anterior horn cells (HP:0002398)2.13954738
56Abnormality of the anterior horn cell (HP:0006802)2.13954738
57Congenital stationary night blindness (HP:0007642)2.12778498
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.10778823
59Aplasia/Hypoplasia of the ulna (HP:0006495)2.10300387
60Dicarboxylic aciduria (HP:0003215)2.08192385
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08192385
62Optic disc pallor (HP:0000543)2.07969575
63Hypoplasia of the pons (HP:0012110)2.07675766
64Abnormality of the phalanges of the 5th finger (HP:0004213)2.07096413
65Exertional dyspnea (HP:0002875)2.05286441
66Abnormality of the preputium (HP:0100587)2.03918928
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.02670952
68Abnormality of the middle phalanges of the toes (HP:0010183)2.02245713
69Hyperglycinuria (HP:0003108)1.99278397
70Attenuation of retinal blood vessels (HP:0007843)1.98125325
71Posterior subcapsular cataract (HP:0007787)1.97676145
72Fatigue (HP:0012378)1.97281616
73Renal Fanconi syndrome (HP:0001994)1.96836052
74Stomatitis (HP:0010280)1.96829102
75Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96548337
76Hypoplasia of the ulna (HP:0003022)1.96012230
77Short tibia (HP:0005736)1.95105015
78Premature ovarian failure (HP:0008209)1.94211019
79Reticulocytopenia (HP:0001896)1.94186484
80Abnormality of vitamin B metabolism (HP:0004340)1.94149181
81Large for gestational age (HP:0001520)1.92986190
82Spinal muscular atrophy (HP:0007269)1.91143673
83Abnormality of the proximal phalanges of the hand (HP:0009834)1.88873089
84Increased IgM level (HP:0003496)1.88470038
85Conjunctival hamartoma (HP:0100780)1.87784705
86Cerebral hemorrhage (HP:0001342)1.85052140
87Ependymoma (HP:0002888)1.84340334
88Microvesicular hepatic steatosis (HP:0001414)1.83302996
89Respiratory difficulties (HP:0002880)1.83034382
90Progressive microcephaly (HP:0000253)1.82805805
91Renal cortical cysts (HP:0000803)1.82737782
92Horseshoe kidney (HP:0000085)1.81260647
93Increased serum pyruvate (HP:0003542)1.79064127
942-3 toe syndactyly (HP:0004691)1.78009955
95IgG deficiency (HP:0004315)1.75999415
96Supernumerary spleens (HP:0009799)1.75595011
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.74465965
98Septo-optic dysplasia (HP:0100842)1.73931670
99Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73395049
100Absent radius (HP:0003974)1.72452170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.91846039
2EIF2AK14.51184015
3EIF2AK34.11102492
4MST43.71271484
5TSSK63.60964135
6VRK23.33498575
7NUAK12.84521797
8SRPK12.73457895
9PLK32.35444216
10TNIK2.23736117
11FRK2.14209759
12BUB12.10756616
13TAF12.07380638
14BMPR1B1.93349128
15VRK11.91203569
16WNK41.87875418
17ZAK1.85586310
18TXK1.84498829
19TRIM281.83659357
20STK41.60907868
21STK391.57310281
22ACVR1B1.51810857
23ADRBK21.43042661
24EIF2AK21.28511424
25PDK21.28360415
26NEK11.28135765
27MAP4K21.25568532
28SCYL21.24389123
29OXSR11.23103822
30MUSK1.22318024
31MKNK11.13869283
32TTK1.12194316
33PLK41.11420735
34MKNK21.09515386
35PINK11.08150206
36NME11.00477598
37GRK10.90780092
38ALK0.88978044
39PASK0.87612162
40NME20.87470495
41DYRK20.85930297
42STK160.81284331
43PLK10.78353486
44TGFBR10.73841757
45PLK20.72275736
46FLT30.72100866
47PIK3CG0.71192141
48STK30.67865494
49CDK80.64820848
50NLK0.60302925
51MAP4K10.60055494
52TIE10.58458661
53TLK10.57762755
54BCKDK0.46328826
55ATR0.45795769
56AKT30.45314940
57IKBKB0.43449530
58RPS6KA50.42178774
59CCNB10.41508014
60CSNK1G10.41351889
61STK38L0.40295311
62PIK3CA0.39976623
63WEE10.38923768
64TEC0.38295463
65PRKCI0.38125373
66INSRR0.37638245
67ATM0.37350373
68MAPKAPK50.36322338
69CSNK2A10.35455931
70PHKG20.35068988
71PHKG10.35068988
72CDC70.34188803
73DMPK0.31711812
74CHEK20.30399848
75ILK0.30236503
76AURKB0.30093229
77BRD40.29839821
78MAPK130.29767622
79FGFR20.29048453
80CSNK1G20.28767882
81CHEK10.28202998
82CSNK2A20.28168204
83RPS6KA40.27923208
84PTK2B0.27501787
85ERBB40.24979866
86PAK10.24862976
87CSNK1E0.23603172
88MYLK0.23397125
89NEK60.22967780
90IGF1R0.21736086
91DAPK10.21606184
92STK240.21241758
93WNK30.21124354
94PRKD30.20334234
95MAP3K80.20310718
96GRK50.19525795
97DYRK30.18287631
98PRKCE0.17435284
99BRSK20.17308226
100CSNK1G30.16945983

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.73550586
2Caffeine metabolism_Homo sapiens_hsa002323.98454898
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73577630
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73178191
5RNA polymerase_Homo sapiens_hsa030202.65325732
6Protein export_Homo sapiens_hsa030602.50895724
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46468304
8Basal transcription factors_Homo sapiens_hsa030222.46357478
9Oxidative phosphorylation_Homo sapiens_hsa001902.42117353
10One carbon pool by folate_Homo sapiens_hsa006702.37179192
11Ribosome_Homo sapiens_hsa030102.21557962
12RNA transport_Homo sapiens_hsa030132.19500736
13Parkinsons disease_Homo sapiens_hsa050122.03717229
14Mismatch repair_Homo sapiens_hsa034302.03265352
15RNA degradation_Homo sapiens_hsa030181.99101767
16Asthma_Homo sapiens_hsa053101.91171582
17Spliceosome_Homo sapiens_hsa030401.72964505
18Propanoate metabolism_Homo sapiens_hsa006401.69185636
19Non-homologous end-joining_Homo sapiens_hsa034501.68578690
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.66611127
21Homologous recombination_Homo sapiens_hsa034401.58471876
22Pyrimidine metabolism_Homo sapiens_hsa002401.52856805
23DNA replication_Homo sapiens_hsa030301.51646295
24Huntingtons disease_Homo sapiens_hsa050161.49816953
25Fanconi anemia pathway_Homo sapiens_hsa034601.45411344
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38489590
27Sulfur metabolism_Homo sapiens_hsa009201.36419172
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34746370
29Linoleic acid metabolism_Homo sapiens_hsa005911.34677875
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27534860
31Nucleotide excision repair_Homo sapiens_hsa034201.26326035
32Purine metabolism_Homo sapiens_hsa002301.22329441
33Allograft rejection_Homo sapiens_hsa053301.20554008
34Selenocompound metabolism_Homo sapiens_hsa004501.19803429
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19176365
36Nitrogen metabolism_Homo sapiens_hsa009101.18325134
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.13872775
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13711533
39Autoimmune thyroid disease_Homo sapiens_hsa053201.12977792
40Base excision repair_Homo sapiens_hsa034101.12722487
41Glutathione metabolism_Homo sapiens_hsa004801.09739133
42Pyruvate metabolism_Homo sapiens_hsa006201.02777443
43Phototransduction_Homo sapiens_hsa047441.01152167
44Collecting duct acid secretion_Homo sapiens_hsa049661.01075117
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99867676
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96453741
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95984300
48Fatty acid elongation_Homo sapiens_hsa000620.95068680
49Alzheimers disease_Homo sapiens_hsa050100.94854551
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93743099
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93405244
52Peroxisome_Homo sapiens_hsa041460.91487539
53Fat digestion and absorption_Homo sapiens_hsa049750.90863212
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90118967
55Tryptophan metabolism_Homo sapiens_hsa003800.89508335
56Chemical carcinogenesis_Homo sapiens_hsa052040.85026669
57Steroid biosynthesis_Homo sapiens_hsa001000.83029671
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83003283
59Arachidonic acid metabolism_Homo sapiens_hsa005900.81910713
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78844283
61Metabolic pathways_Homo sapiens_hsa011000.76172374
62Cell cycle_Homo sapiens_hsa041100.67310035
63Folate biosynthesis_Homo sapiens_hsa007900.66440385
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65198155
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.61714930
66Vitamin B6 metabolism_Homo sapiens_hsa007500.59343780
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56015257
68Carbon metabolism_Homo sapiens_hsa012000.54227336
69Fatty acid biosynthesis_Homo sapiens_hsa000610.53034097
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.52531586
71Arginine and proline metabolism_Homo sapiens_hsa003300.52154717
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.51853768
73Retinol metabolism_Homo sapiens_hsa008300.49235329
74Oocyte meiosis_Homo sapiens_hsa041140.48185534
75Dorso-ventral axis formation_Homo sapiens_hsa043200.45859965
76Fatty acid degradation_Homo sapiens_hsa000710.45826851
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44224040
78Ovarian steroidogenesis_Homo sapiens_hsa049130.42646601
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42438036
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41829675
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41633587
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.41133072
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41033169
84Antigen processing and presentation_Homo sapiens_hsa046120.40694213
85p53 signaling pathway_Homo sapiens_hsa041150.38574895
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37960186
87Cardiac muscle contraction_Homo sapiens_hsa042600.37468670
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36581000
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35911654
90Ether lipid metabolism_Homo sapiens_hsa005650.35600699
91Olfactory transduction_Homo sapiens_hsa047400.35076204
92TGF-beta signaling pathway_Homo sapiens_hsa043500.34740155
93Biosynthesis of amino acids_Homo sapiens_hsa012300.34593177
94beta-Alanine metabolism_Homo sapiens_hsa004100.34453917
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33551327
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32834919
97Hematopoietic cell lineage_Homo sapiens_hsa046400.32118051
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.30746728
99Starch and sucrose metabolism_Homo sapiens_hsa005000.30427860
100Primary immunodeficiency_Homo sapiens_hsa053400.29441082

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