

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | piRNA metabolic process (GO:0034587) | 6.40952673 |
| 2 | DNA deamination (GO:0045006) | 6.04359881 |
| 3 | protein neddylation (GO:0045116) | 5.48300871 |
| 4 | proteasome assembly (GO:0043248) | 5.28164955 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.98305753 |
| 6 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.92099416 |
| 7 | ribosome assembly (GO:0042255) | 4.88856848 |
| 8 | mitochondrial RNA metabolic process (GO:0000959) | 4.57075938 |
| 9 | transcription from mitochondrial promoter (GO:0006390) | 4.56904764 |
| 10 | DNA methylation involved in gamete generation (GO:0043046) | 4.50542197 |
| 11 | rRNA modification (GO:0000154) | 4.40227269 |
| 12 | maturation of 5.8S rRNA (GO:0000460) | 4.24262302 |
| 13 | peptidyl-histidine modification (GO:0018202) | 4.07797708 |
| 14 | resolution of meiotic recombination intermediates (GO:0000712) | 3.98839571 |
| 15 | rRNA methylation (GO:0031167) | 3.96001320 |
| 16 | chaperone-mediated protein transport (GO:0072321) | 3.95845045 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.78574508 |
| 18 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.73820024 |
| 19 | pseudouridine synthesis (GO:0001522) | 3.68766450 |
| 20 | respiratory chain complex IV assembly (GO:0008535) | 3.65999837 |
| 21 | protein complex biogenesis (GO:0070271) | 3.64322099 |
| 22 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.64258286 |
| 23 | cullin deneddylation (GO:0010388) | 3.63619242 |
| 24 | cytochrome complex assembly (GO:0017004) | 3.61097223 |
| 25 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.60392546 |
| 26 | protein deneddylation (GO:0000338) | 3.58735112 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.58326784 |
| 28 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.57524132 |
| 29 | kinetochore assembly (GO:0051382) | 3.57451690 |
| 30 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.54369913 |
| 31 | negative regulation of ligase activity (GO:0051352) | 3.54369913 |
| 32 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.46953740 |
| 33 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.46953740 |
| 34 | isotype switching (GO:0045190) | 3.46953740 |
| 35 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.45152331 |
| 36 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.44279758 |
| 37 | DNA double-strand break processing (GO:0000729) | 3.43144892 |
| 38 | regulation of chronic inflammatory response (GO:0002676) | 3.38535663 |
| 39 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.37647739 |
| 40 | chromatin remodeling at centromere (GO:0031055) | 3.36551436 |
| 41 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.33918205 |
| 42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.32897120 |
| 43 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.32897120 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.32897120 |
| 45 | CENP-A containing nucleosome assembly (GO:0034080) | 3.31746412 |
| 46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.28840028 |
| 47 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.28840028 |
| 48 | meiotic chromosome segregation (GO:0045132) | 3.27834203 |
| 49 | tRNA aminoacylation for protein translation (GO:0006418) | 3.22694019 |
| 50 | lactate metabolic process (GO:0006089) | 3.21878172 |
| 51 | tRNA aminoacylation (GO:0043039) | 3.21117220 |
| 52 | amino acid activation (GO:0043038) | 3.21117220 |
| 53 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.20708026 |
| 54 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.20429719 |
| 55 | NADH dehydrogenase complex assembly (GO:0010257) | 3.20429719 |
| 56 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.20429719 |
| 57 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.19212900 |
| 58 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.16602946 |
| 59 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.16602946 |
| 60 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.15335654 |
| 61 | kinetochore organization (GO:0051383) | 3.14279692 |
| 62 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.13097474 |
| 63 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.13097474 |
| 64 | histone exchange (GO:0043486) | 3.09946168 |
| 65 | positive regulation of ligase activity (GO:0051351) | 3.09504354 |
| 66 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.08972978 |
| 67 | non-recombinational repair (GO:0000726) | 3.08972978 |
| 68 | protein-cofactor linkage (GO:0018065) | 3.04992929 |
| 69 | replication fork processing (GO:0031297) | 3.03969406 |
| 70 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.03500608 |
| 71 | ATP synthesis coupled proton transport (GO:0015986) | 3.03500608 |
| 72 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.02678898 |
| 73 | mitochondrial DNA replication (GO:0006264) | 3.02202529 |
| 74 | termination of RNA polymerase I transcription (GO:0006363) | 3.00584600 |
| 75 | rRNA processing (GO:0006364) | 3.00212721 |
| 76 | synapsis (GO:0007129) | 2.96936940 |
| 77 | tRNA metabolic process (GO:0006399) | 2.96305888 |
| 78 | ribosomal large subunit biogenesis (GO:0042273) | 2.96184453 |
| 79 | intracellular protein transmembrane import (GO:0044743) | 2.95928396 |
| 80 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.95568723 |
| 81 | rRNA metabolic process (GO:0016072) | 2.95166435 |
| 82 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.94885344 |
| 83 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.94025439 |
| 84 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.93440746 |
| 85 | protein targeting to mitochondrion (GO:0006626) | 2.93374897 |
| 86 | regulation of ligase activity (GO:0051340) | 2.86388251 |
| 87 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.83523879 |
| 88 | ncRNA metabolic process (GO:0034660) | 2.82616631 |
| 89 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.82615429 |
| 90 | regulation of immunoglobulin secretion (GO:0051023) | 2.81289462 |
| 91 | establishment of protein localization to mitochondrion (GO:0072655) | 2.81115829 |
| 92 | IMP biosynthetic process (GO:0006188) | 2.80591827 |
| 93 | tRNA processing (GO:0008033) | 2.80478765 |
| 94 | positive regulation of isotype switching (GO:0045830) | 2.79144005 |
| 95 | nucleobase biosynthetic process (GO:0046112) | 2.76937636 |
| 96 | protein localization to mitochondrion (GO:0070585) | 2.76797944 |
| 97 | ribosomal small subunit assembly (GO:0000028) | 2.76778940 |
| 98 | male meiosis (GO:0007140) | 2.73716523 |
| 99 | oxidative phosphorylation (GO:0006119) | 2.73654640 |
| 100 | somatic diversification of immunoglobulins (GO:0016445) | 2.73020806 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.16771111 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.64129249 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.89957669 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.43014290 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.37482940 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.32817131 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.20911186 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.99661332 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.91266532 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.70533977 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.67649052 |
| 12 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.66282801 |
| 13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.56532589 |
| 14 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.46069483 |
| 15 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.44717713 |
| 16 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.41850427 |
| 17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.40090629 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.35971309 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.30295963 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.30152893 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.23024206 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.22211496 |
| 23 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.17786951 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.10557718 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.02987539 |
| 26 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.02911583 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.97552208 |
| 28 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.93775460 |
| 29 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.93617521 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.92692744 |
| 31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.91662033 |
| 32 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.91261730 |
| 33 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.90979217 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.88242409 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.82780151 |
| 36 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.76320578 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.75712038 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.69641097 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.65384161 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64537394 |
| 41 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.64231891 |
| 42 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.62671835 |
| 43 | EWS_26573619_Chip-Seq_HEK293_Human | 1.62589595 |
| 44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.60677325 |
| 45 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.57611862 |
| 46 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56895268 |
| 47 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.53224408 |
| 48 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.48931710 |
| 49 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.48325871 |
| 50 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.46285490 |
| 51 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.45564188 |
| 52 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.44322586 |
| 53 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.43319442 |
| 54 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.42017013 |
| 55 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.36838197 |
| 56 | FUS_26573619_Chip-Seq_HEK293_Human | 1.26273657 |
| 57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.25134549 |
| 58 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.23867928 |
| 59 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.21448312 |
| 60 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.19478595 |
| 61 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.15465530 |
| 62 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.11615875 |
| 63 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.11256799 |
| 64 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.10752195 |
| 65 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08178348 |
| 66 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.06215429 |
| 67 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.05141725 |
| 68 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.02833712 |
| 69 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.02833712 |
| 70 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.00933002 |
| 71 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.99257697 |
| 72 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.97474593 |
| 73 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.97474593 |
| 74 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.97286270 |
| 75 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.94607351 |
| 76 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.94282092 |
| 77 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.92316416 |
| 78 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91542998 |
| 79 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.91494964 |
| 80 | P300_19829295_ChIP-Seq_ESCs_Human | 0.89614532 |
| 81 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.88730146 |
| 82 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88420568 |
| 83 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.87110181 |
| 84 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.86744160 |
| 85 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.85526095 |
| 86 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.85069771 |
| 87 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.82633811 |
| 88 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.81940055 |
| 89 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.80515147 |
| 90 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.78431216 |
| 91 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.78024445 |
| 92 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.78024445 |
| 93 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.78024445 |
| 94 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.77680870 |
| 95 | AR_20517297_ChIP-Seq_VCAP_Human | 0.77061751 |
| 96 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.76764287 |
| 97 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.76728157 |
| 98 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.76531271 |
| 99 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.75897150 |
| 100 | GATA3_26560356_Chip-Seq_TH2_Human | 0.75859116 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003718_maternal_effect | 4.33482226 |
| 2 | MP0008875_abnormal_xenobiotic_pharmacok | 3.92296067 |
| 3 | MP0003646_muscle_fatigue | 3.71041419 |
| 4 | MP0008058_abnormal_DNA_repair | 3.35468926 |
| 5 | MP0008877_abnormal_DNA_methylation | 3.31084066 |
| 6 | MP0003186_abnormal_redox_activity | 3.08754855 |
| 7 | MP0008872_abnormal_physiological_respon | 2.99124878 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.89436772 |
| 9 | MP0002837_dystrophic_cardiac_calcinosis | 2.74618517 |
| 10 | MP0008775_abnormal_heart_ventricle | 2.70322632 |
| 11 | MP0003567_abnormal_fetal_cardiomyocyte | 2.54606015 |
| 12 | MP0004957_abnormal_blastocyst_morpholog | 2.42914448 |
| 13 | MP0005084_abnormal_gallbladder_morpholo | 2.37863461 |
| 14 | MP0002254_reproductive_system_inflammat | 2.19072948 |
| 15 | MP0006292_abnormal_olfactory_placode | 2.18356992 |
| 16 | MP0001873_stomach_inflammation | 2.17841177 |
| 17 | MP0010094_abnormal_chromosome_stability | 2.11975701 |
| 18 | MP0008007_abnormal_cellular_replicative | 1.88877388 |
| 19 | MP0002160_abnormal_reproductive_system | 1.84637137 |
| 20 | MP0009697_abnormal_copulation | 1.83578562 |
| 21 | MP0004145_abnormal_muscle_electrophysio | 1.79609173 |
| 22 | MP0002736_abnormal_nociception_after | 1.79170157 |
| 23 | MP0001348_abnormal_lacrimal_gland | 1.76309713 |
| 24 | MP0003786_premature_aging | 1.63632891 |
| 25 | MP0003806_abnormal_nucleotide_metabolis | 1.63396437 |
| 26 | MP0001984_abnormal_olfaction | 1.61845950 |
| 27 | MP0006054_spinal_hemorrhage | 1.61363765 |
| 28 | MP0001835_abnormal_antigen_presentation | 1.59231029 |
| 29 | MP0002138_abnormal_hepatobiliary_system | 1.57997195 |
| 30 | MP0003950_abnormal_plasma_membrane | 1.56060788 |
| 31 | MP0008932_abnormal_embryonic_tissue | 1.54609402 |
| 32 | MP0008789_abnormal_olfactory_epithelium | 1.54561279 |
| 33 | MP0002210_abnormal_sex_determination | 1.50052139 |
| 34 | MP0005389_reproductive_system_phenotype | 1.48672877 |
| 35 | MP0005395_other_phenotype | 1.44982729 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.43740696 |
| 37 | MP0001929_abnormal_gametogenesis | 1.37398892 |
| 38 | MP0006072_abnormal_retinal_apoptosis | 1.36643337 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.35216522 |
| 40 | MP0003077_abnormal_cell_cycle | 1.31921265 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.30142194 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.25340289 |
| 43 | MP0005075_abnormal_melanosome_morpholog | 1.16826937 |
| 44 | MP0000653_abnormal_sex_gland | 1.16414711 |
| 45 | MP0001188_hyperpigmentation | 1.16218804 |
| 46 | MP0005410_abnormal_fertilization | 1.16020097 |
| 47 | MP0009765_abnormal_xenobiotic_induced | 1.15956744 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 1.14493232 |
| 49 | MP0000427_abnormal_hair_cycle | 1.11110762 |
| 50 | MP0001119_abnormal_female_reproductive | 1.09564378 |
| 51 | MP0004084_abnormal_cardiac_muscle | 1.09185767 |
| 52 | MP0004215_abnormal_myocardial_fiber | 1.09049217 |
| 53 | MP0002876_abnormal_thyroid_physiology | 1.08119577 |
| 54 | MP0001145_abnormal_male_reproductive | 1.07577908 |
| 55 | MP0001666_abnormal_nutrient_absorption | 1.06084274 |
| 56 | MP0003111_abnormal_nucleus_morphology | 1.04537825 |
| 57 | MP0002751_abnormal_autonomic_nervous | 1.04487528 |
| 58 | MP0002102_abnormal_ear_morphology | 1.03267420 |
| 59 | MP0009780_abnormal_chondrocyte_physiolo | 1.02872762 |
| 60 | MP0002928_abnormal_bile_duct | 1.02072370 |
| 61 | MP0004782_abnormal_surfactant_physiolog | 0.99751625 |
| 62 | MP0005332_abnormal_amino_acid | 0.98223255 |
| 63 | MP0003937_abnormal_limbs/digits/tail_de | 0.94769073 |
| 64 | MP0006082_CNS_inflammation | 0.94526816 |
| 65 | MP0001853_heart_inflammation | 0.93083093 |
| 66 | MP0001485_abnormal_pinna_reflex | 0.91735752 |
| 67 | MP0002277_abnormal_respiratory_mucosa | 0.90037500 |
| 68 | MP0005083_abnormal_biliary_tract | 0.86700881 |
| 69 | MP0001730_embryonic_growth_arrest | 0.86311017 |
| 70 | MP0003011_delayed_dark_adaptation | 0.85104667 |
| 71 | MP0005319_abnormal_enzyme/_coenzyme | 0.82413245 |
| 72 | MP0000490_abnormal_crypts_of | 0.81204832 |
| 73 | MP0004142_abnormal_muscle_tone | 0.80921774 |
| 74 | MP0003698_abnormal_male_reproductive | 0.78802698 |
| 75 | MP0001919_abnormal_reproductive_system | 0.78559880 |
| 76 | MP0001661_extended_life_span | 0.77129919 |
| 77 | MP0003890_abnormal_embryonic-extraembry | 0.76696786 |
| 78 | MP0005551_abnormal_eye_electrophysiolog | 0.75295316 |
| 79 | MP0003936_abnormal_reproductive_system | 0.73886735 |
| 80 | MP0001905_abnormal_dopamine_level | 0.73603576 |
| 81 | MP0001529_abnormal_vocalization | 0.72708368 |
| 82 | MP0002084_abnormal_developmental_patter | 0.72534522 |
| 83 | MP0008057_abnormal_DNA_replication | 0.71987808 |
| 84 | MP0000313_abnormal_cell_death | 0.70386914 |
| 85 | MP0001764_abnormal_homeostasis | 0.70087197 |
| 86 | MP0001881_abnormal_mammary_gland | 0.68641916 |
| 87 | MP0008873_increased_physiological_sensi | 0.68134362 |
| 88 | MP0003252_abnormal_bile_duct | 0.67806224 |
| 89 | MP0002148_abnormal_hypersensitivity_rea | 0.66465004 |
| 90 | MP0002006_tumorigenesis | 0.64938307 |
| 91 | MP0001697_abnormal_embryo_size | 0.64532883 |
| 92 | MP0000358_abnormal_cell_content/ | 0.63218504 |
| 93 | MP0004133_heterotaxia | 0.62604136 |
| 94 | MP0009250_abnormal_appendicular_skeleto | 0.62407695 |
| 95 | MP0005636_abnormal_mineral_homeostasis | 0.62329277 |
| 96 | MP0009764_decreased_sensitivity_to | 0.62066232 |
| 97 | MP0005499_abnormal_olfactory_system | 0.61833594 |
| 98 | MP0005394_taste/olfaction_phenotype | 0.61833594 |
| 99 | MP0005380_embryogenesis_phenotype | 0.61243734 |
| 100 | MP0001672_abnormal_embryogenesis/_devel | 0.61243734 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.90730265 |
| 2 | 3-Methylglutaconic aciduria (HP:0003535) | 3.77589799 |
| 3 | Abnormality of the labia minora (HP:0012880) | 3.74342095 |
| 4 | Progressive macrocephaly (HP:0004481) | 3.63396025 |
| 5 | Methylmalonic acidemia (HP:0002912) | 3.60572953 |
| 6 | Acute encephalopathy (HP:0006846) | 3.58189929 |
| 7 | Increased CSF lactate (HP:0002490) | 3.50884326 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.49277102 |
| 9 | Methylmalonic aciduria (HP:0012120) | 3.36490276 |
| 10 | Increased serum lactate (HP:0002151) | 3.34757789 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.26022376 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.21626351 |
| 13 | Hepatic necrosis (HP:0002605) | 2.99259706 |
| 14 | Cutaneous melanoma (HP:0012056) | 2.95513108 |
| 15 | Increased hepatocellular lipid droplets (HP:0006565) | 2.94413372 |
| 16 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.92896511 |
| 17 | Hyperglycinemia (HP:0002154) | 2.90951358 |
| 18 | Hypoplasia of the uterus (HP:0000013) | 2.86587226 |
| 19 | Colon cancer (HP:0003003) | 2.82782012 |
| 20 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.81466285 |
| 21 | Fibular aplasia (HP:0002990) | 2.78711814 |
| 22 | Abnormality of alanine metabolism (HP:0010916) | 2.75323562 |
| 23 | Hyperalaninemia (HP:0003348) | 2.75323562 |
| 24 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.75323562 |
| 25 | Lipid accumulation in hepatocytes (HP:0006561) | 2.70197538 |
| 26 | Gonadotropin excess (HP:0000837) | 2.68962372 |
| 27 | Abnormality of the pons (HP:0007361) | 2.67831159 |
| 28 | Chromsome breakage (HP:0040012) | 2.65754684 |
| 29 | Cerebral edema (HP:0002181) | 2.63501099 |
| 30 | Pancreatic cysts (HP:0001737) | 2.59499632 |
| 31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.54811920 |
| 32 | Adactyly (HP:0009776) | 2.54755613 |
| 33 | Duplicated collecting system (HP:0000081) | 2.48158997 |
| 34 | Lethargy (HP:0001254) | 2.44204744 |
| 35 | Lactic acidosis (HP:0003128) | 2.40773256 |
| 36 | Abnormality of the renal collecting system (HP:0004742) | 2.38292893 |
| 37 | Cerebral hypomyelination (HP:0006808) | 2.34830990 |
| 38 | Meckel diverticulum (HP:0002245) | 2.34669626 |
| 39 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.34460744 |
| 40 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.34094582 |
| 41 | CNS demyelination (HP:0007305) | 2.32003178 |
| 42 | Pancytopenia (HP:0001876) | 2.30736715 |
| 43 | Carpal bone hypoplasia (HP:0001498) | 2.29452541 |
| 44 | Abnormality of glycine metabolism (HP:0010895) | 2.28702640 |
| 45 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.28702640 |
| 46 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.26829587 |
| 47 | Absent thumb (HP:0009777) | 2.26481684 |
| 48 | Abnormality of the ileum (HP:0001549) | 2.23325708 |
| 49 | Abnormality of serum amino acid levels (HP:0003112) | 2.23033622 |
| 50 | Tubulointerstitial nephritis (HP:0001970) | 2.20861769 |
| 51 | Meningioma (HP:0002858) | 2.20671707 |
| 52 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.18073739 |
| 53 | Respiratory failure (HP:0002878) | 2.14892303 |
| 54 | Exercise intolerance (HP:0003546) | 2.14191839 |
| 55 | Degeneration of anterior horn cells (HP:0002398) | 2.13954738 |
| 56 | Abnormality of the anterior horn cell (HP:0006802) | 2.13954738 |
| 57 | Congenital stationary night blindness (HP:0007642) | 2.12778498 |
| 58 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.10778823 |
| 59 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 2.10300387 |
| 60 | Dicarboxylic aciduria (HP:0003215) | 2.08192385 |
| 61 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.08192385 |
| 62 | Optic disc pallor (HP:0000543) | 2.07969575 |
| 63 | Hypoplasia of the pons (HP:0012110) | 2.07675766 |
| 64 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.07096413 |
| 65 | Exertional dyspnea (HP:0002875) | 2.05286441 |
| 66 | Abnormality of the preputium (HP:0100587) | 2.03918928 |
| 67 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.02670952 |
| 68 | Abnormality of the middle phalanges of the toes (HP:0010183) | 2.02245713 |
| 69 | Hyperglycinuria (HP:0003108) | 1.99278397 |
| 70 | Attenuation of retinal blood vessels (HP:0007843) | 1.98125325 |
| 71 | Posterior subcapsular cataract (HP:0007787) | 1.97676145 |
| 72 | Fatigue (HP:0012378) | 1.97281616 |
| 73 | Renal Fanconi syndrome (HP:0001994) | 1.96836052 |
| 74 | Stomatitis (HP:0010280) | 1.96829102 |
| 75 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.96548337 |
| 76 | Hypoplasia of the ulna (HP:0003022) | 1.96012230 |
| 77 | Short tibia (HP:0005736) | 1.95105015 |
| 78 | Premature ovarian failure (HP:0008209) | 1.94211019 |
| 79 | Reticulocytopenia (HP:0001896) | 1.94186484 |
| 80 | Abnormality of vitamin B metabolism (HP:0004340) | 1.94149181 |
| 81 | Large for gestational age (HP:0001520) | 1.92986190 |
| 82 | Spinal muscular atrophy (HP:0007269) | 1.91143673 |
| 83 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.88873089 |
| 84 | Increased IgM level (HP:0003496) | 1.88470038 |
| 85 | Conjunctival hamartoma (HP:0100780) | 1.87784705 |
| 86 | Cerebral hemorrhage (HP:0001342) | 1.85052140 |
| 87 | Ependymoma (HP:0002888) | 1.84340334 |
| 88 | Microvesicular hepatic steatosis (HP:0001414) | 1.83302996 |
| 89 | Respiratory difficulties (HP:0002880) | 1.83034382 |
| 90 | Progressive microcephaly (HP:0000253) | 1.82805805 |
| 91 | Renal cortical cysts (HP:0000803) | 1.82737782 |
| 92 | Horseshoe kidney (HP:0000085) | 1.81260647 |
| 93 | Increased serum pyruvate (HP:0003542) | 1.79064127 |
| 94 | 2-3 toe syndactyly (HP:0004691) | 1.78009955 |
| 95 | IgG deficiency (HP:0004315) | 1.75999415 |
| 96 | Supernumerary spleens (HP:0009799) | 1.75595011 |
| 97 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.74465965 |
| 98 | Septo-optic dysplasia (HP:0100842) | 1.73931670 |
| 99 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.73395049 |
| 100 | Absent radius (HP:0003974) | 1.72452170 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PBK | 5.91846039 |
| 2 | EIF2AK1 | 4.51184015 |
| 3 | EIF2AK3 | 4.11102492 |
| 4 | MST4 | 3.71271484 |
| 5 | TSSK6 | 3.60964135 |
| 6 | VRK2 | 3.33498575 |
| 7 | NUAK1 | 2.84521797 |
| 8 | SRPK1 | 2.73457895 |
| 9 | PLK3 | 2.35444216 |
| 10 | TNIK | 2.23736117 |
| 11 | FRK | 2.14209759 |
| 12 | BUB1 | 2.10756616 |
| 13 | TAF1 | 2.07380638 |
| 14 | BMPR1B | 1.93349128 |
| 15 | VRK1 | 1.91203569 |
| 16 | WNK4 | 1.87875418 |
| 17 | ZAK | 1.85586310 |
| 18 | TXK | 1.84498829 |
| 19 | TRIM28 | 1.83659357 |
| 20 | STK4 | 1.60907868 |
| 21 | STK39 | 1.57310281 |
| 22 | ACVR1B | 1.51810857 |
| 23 | ADRBK2 | 1.43042661 |
| 24 | EIF2AK2 | 1.28511424 |
| 25 | PDK2 | 1.28360415 |
| 26 | NEK1 | 1.28135765 |
| 27 | MAP4K2 | 1.25568532 |
| 28 | SCYL2 | 1.24389123 |
| 29 | OXSR1 | 1.23103822 |
| 30 | MUSK | 1.22318024 |
| 31 | MKNK1 | 1.13869283 |
| 32 | TTK | 1.12194316 |
| 33 | PLK4 | 1.11420735 |
| 34 | MKNK2 | 1.09515386 |
| 35 | PINK1 | 1.08150206 |
| 36 | NME1 | 1.00477598 |
| 37 | GRK1 | 0.90780092 |
| 38 | ALK | 0.88978044 |
| 39 | PASK | 0.87612162 |
| 40 | NME2 | 0.87470495 |
| 41 | DYRK2 | 0.85930297 |
| 42 | STK16 | 0.81284331 |
| 43 | PLK1 | 0.78353486 |
| 44 | TGFBR1 | 0.73841757 |
| 45 | PLK2 | 0.72275736 |
| 46 | FLT3 | 0.72100866 |
| 47 | PIK3CG | 0.71192141 |
| 48 | STK3 | 0.67865494 |
| 49 | CDK8 | 0.64820848 |
| 50 | NLK | 0.60302925 |
| 51 | MAP4K1 | 0.60055494 |
| 52 | TIE1 | 0.58458661 |
| 53 | TLK1 | 0.57762755 |
| 54 | BCKDK | 0.46328826 |
| 55 | ATR | 0.45795769 |
| 56 | AKT3 | 0.45314940 |
| 57 | IKBKB | 0.43449530 |
| 58 | RPS6KA5 | 0.42178774 |
| 59 | CCNB1 | 0.41508014 |
| 60 | CSNK1G1 | 0.41351889 |
| 61 | STK38L | 0.40295311 |
| 62 | PIK3CA | 0.39976623 |
| 63 | WEE1 | 0.38923768 |
| 64 | TEC | 0.38295463 |
| 65 | PRKCI | 0.38125373 |
| 66 | INSRR | 0.37638245 |
| 67 | ATM | 0.37350373 |
| 68 | MAPKAPK5 | 0.36322338 |
| 69 | CSNK2A1 | 0.35455931 |
| 70 | PHKG2 | 0.35068988 |
| 71 | PHKG1 | 0.35068988 |
| 72 | CDC7 | 0.34188803 |
| 73 | DMPK | 0.31711812 |
| 74 | CHEK2 | 0.30399848 |
| 75 | ILK | 0.30236503 |
| 76 | AURKB | 0.30093229 |
| 77 | BRD4 | 0.29839821 |
| 78 | MAPK13 | 0.29767622 |
| 79 | FGFR2 | 0.29048453 |
| 80 | CSNK1G2 | 0.28767882 |
| 81 | CHEK1 | 0.28202998 |
| 82 | CSNK2A2 | 0.28168204 |
| 83 | RPS6KA4 | 0.27923208 |
| 84 | PTK2B | 0.27501787 |
| 85 | ERBB4 | 0.24979866 |
| 86 | PAK1 | 0.24862976 |
| 87 | CSNK1E | 0.23603172 |
| 88 | MYLK | 0.23397125 |
| 89 | NEK6 | 0.22967780 |
| 90 | IGF1R | 0.21736086 |
| 91 | DAPK1 | 0.21606184 |
| 92 | STK24 | 0.21241758 |
| 93 | WNK3 | 0.21124354 |
| 94 | PRKD3 | 0.20334234 |
| 95 | MAP3K8 | 0.20310718 |
| 96 | GRK5 | 0.19525795 |
| 97 | DYRK3 | 0.18287631 |
| 98 | PRKCE | 0.17435284 |
| 99 | BRSK2 | 0.17308226 |
| 100 | CSNK1G3 | 0.16945983 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.73550586 |
| 2 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.98454898 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.73577630 |
| 4 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.73178191 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.65325732 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.50895724 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.46468304 |
| 8 | Basal transcription factors_Homo sapiens_hsa03022 | 2.46357478 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.42117353 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.37179192 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 2.21557962 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.19500736 |
| 13 | Parkinsons disease_Homo sapiens_hsa05012 | 2.03717229 |
| 14 | Mismatch repair_Homo sapiens_hsa03430 | 2.03265352 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 1.99101767 |
| 16 | Asthma_Homo sapiens_hsa05310 | 1.91171582 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 1.72964505 |
| 18 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.69185636 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.68578690 |
| 20 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.66611127 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.58471876 |
| 22 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.52856805 |
| 23 | DNA replication_Homo sapiens_hsa03030 | 1.51646295 |
| 24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.49816953 |
| 25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.45411344 |
| 26 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.38489590 |
| 27 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.36419172 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34746370 |
| 29 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.34677875 |
| 30 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.27534860 |
| 31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.26326035 |
| 32 | Purine metabolism_Homo sapiens_hsa00230 | 1.22329441 |
| 33 | Allograft rejection_Homo sapiens_hsa05330 | 1.20554008 |
| 34 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.19803429 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.19176365 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.18325134 |
| 37 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.13872775 |
| 38 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.13711533 |
| 39 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.12977792 |
| 40 | Base excision repair_Homo sapiens_hsa03410 | 1.12722487 |
| 41 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.09739133 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.02777443 |
| 43 | Phototransduction_Homo sapiens_hsa04744 | 1.01152167 |
| 44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.01075117 |
| 45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.99867676 |
| 46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.96453741 |
| 47 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.95984300 |
| 48 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.95068680 |
| 49 | Alzheimers disease_Homo sapiens_hsa05010 | 0.94854551 |
| 50 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.93743099 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.93405244 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.91487539 |
| 53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.90863212 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.90118967 |
| 55 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.89508335 |
| 56 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.85026669 |
| 57 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.83029671 |
| 58 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.83003283 |
| 59 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.81910713 |
| 60 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.78844283 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76172374 |
| 62 | Cell cycle_Homo sapiens_hsa04110 | 0.67310035 |
| 63 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.66440385 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.65198155 |
| 65 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.61714930 |
| 66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.59343780 |
| 67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.56015257 |
| 68 | Carbon metabolism_Homo sapiens_hsa01200 | 0.54227336 |
| 69 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.53034097 |
| 70 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.52531586 |
| 71 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.52154717 |
| 72 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.51853768 |
| 73 | Retinol metabolism_Homo sapiens_hsa00830 | 0.49235329 |
| 74 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.48185534 |
| 75 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.45859965 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.45826851 |
| 77 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.44224040 |
| 78 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.42646601 |
| 79 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.42438036 |
| 80 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41829675 |
| 81 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.41633587 |
| 82 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.41133072 |
| 83 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.41033169 |
| 84 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.40694213 |
| 85 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38574895 |
| 86 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.37960186 |
| 87 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.37468670 |
| 88 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36581000 |
| 89 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.35911654 |
| 90 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.35600699 |
| 91 | Olfactory transduction_Homo sapiens_hsa04740 | 0.35076204 |
| 92 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.34740155 |
| 93 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.34593177 |
| 94 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.34453917 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.33551327 |
| 96 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.32834919 |
| 97 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32118051 |
| 98 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.30746728 |
| 99 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.30427860 |
| 100 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.29441082 |

