PRDX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.90011020
2protoporphyrinogen IX metabolic process (GO:0046501)6.51831657
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.46312268
4ATP synthesis coupled proton transport (GO:0015986)6.46312268
5protoporphyrinogen IX biosynthetic process (GO:0006782)6.45994666
6chaperone-mediated protein transport (GO:0072321)4.78701891
7heme biosynthetic process (GO:0006783)4.74585224
8viral transcription (GO:0019083)4.73753160
9translational termination (GO:0006415)4.55331004
10porphyrin-containing compound biosynthetic process (GO:0006779)4.44311453
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43568027
12respiratory electron transport chain (GO:0022904)4.30589265
13cullin deneddylation (GO:0010388)4.28232402
14ribosomal small subunit assembly (GO:0000028)4.24058020
15electron transport chain (GO:0022900)4.19539856
16ribosomal small subunit biogenesis (GO:0042274)4.18556735
17protein deneddylation (GO:0000338)4.00553232
18tetrapyrrole biosynthetic process (GO:0033014)4.00473785
19translational elongation (GO:0006414)3.97712708
20negative regulation of microtubule polymerization (GO:0031115)3.90527066
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87655907
22cotranslational protein targeting to membrane (GO:0006613)3.85774617
23cellular protein complex disassembly (GO:0043624)3.83983366
24protein targeting to ER (GO:0045047)3.79873491
25protein neddylation (GO:0045116)3.75550963
26establishment of integrated proviral latency (GO:0075713)3.74562469
27viral life cycle (GO:0019058)3.69997695
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69452213
29maturation of SSU-rRNA (GO:0030490)3.64733703
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.61637823
31translational initiation (GO:0006413)3.59038109
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.56928065
33NADH dehydrogenase complex assembly (GO:0010257)3.56928065
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56928065
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56523821
36protein-cofactor linkage (GO:0018065)3.55156036
37protein localization to endoplasmic reticulum (GO:0070972)3.54109543
38protein complex disassembly (GO:0043241)3.49505136
39heme metabolic process (GO:0042168)3.48235328
40spliceosomal complex assembly (GO:0000245)3.46336346
41proteasome assembly (GO:0043248)3.44647064
42protein complex biogenesis (GO:0070271)3.44175128
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41124953
44spliceosomal snRNP assembly (GO:0000387)3.39094244
45negative regulation of ligase activity (GO:0051352)3.37518539
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37518539
47macromolecular complex disassembly (GO:0032984)3.36937179
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35052526
49de novo posttranslational protein folding (GO:0051084)3.34758534
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31975714
51porphyrin-containing compound metabolic process (GO:0006778)3.28968507
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27079477
53mitochondrial respiratory chain complex assembly (GO:0033108)3.22829762
54ATP biosynthetic process (GO:0006754)3.20006748
55pyrimidine nucleobase catabolic process (GO:0006208)3.17501735
56de novo protein folding (GO:0006458)3.17177594
57oxidative phosphorylation (GO:0006119)3.16882337
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16569077
59peptidyl-arginine omega-N-methylation (GO:0035247)3.13921308
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10897960
61translation (GO:0006412)3.10132269
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09316151
63regulation of cellular amino acid metabolic process (GO:0006521)3.07982019
64GTP biosynthetic process (GO:0006183)3.04537229
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03990413
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03990413
67establishment of viral latency (GO:0019043)3.01294712
68ribosomal large subunit biogenesis (GO:0042273)2.99802389
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.99654853
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97629413
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97629413
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97629413
73inner mitochondrial membrane organization (GO:0007007)2.95361218
74signal transduction involved in cell cycle checkpoint (GO:0072395)2.94591689
75microtubule depolymerization (GO:0007019)2.93924174
767-methylguanosine mRNA capping (GO:0006370)2.93600699
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93375151
78pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92600019
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.91871971
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91871971
81RNA capping (GO:0036260)2.90987723
827-methylguanosine RNA capping (GO:0009452)2.90987723
83ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86770380
84histone arginine methylation (GO:0034969)2.86408065
85DNA strand elongation involved in DNA replication (GO:0006271)2.85598996
86deoxyribonucleotide biosynthetic process (GO:0009263)2.84037691
87deoxyribose phosphate biosynthetic process (GO:0046385)2.83928598
882-deoxyribonucleotide biosynthetic process (GO:0009265)2.83928598
89hydrogen ion transmembrane transport (GO:1902600)2.81776526
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.80417441
91termination of RNA polymerase III transcription (GO:0006386)2.80417441
92positive regulation of ligase activity (GO:0051351)2.80214218
93peptidyl-arginine N-methylation (GO:0035246)2.78067164
94peptidyl-arginine methylation (GO:0018216)2.78067164
95viral mRNA export from host cell nucleus (GO:0046784)2.77600920
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75559521
97DNA damage response, detection of DNA damage (GO:0042769)2.74660529
98respiratory chain complex IV assembly (GO:0008535)2.74088647
99protein targeting to mitochondrion (GO:0006626)2.73632693
100UTP biosynthetic process (GO:0006228)2.72016499
101aldehyde catabolic process (GO:0046185)2.71772558
102DNA strand elongation (GO:0022616)2.70696228
103regulation of mitochondrial translation (GO:0070129)2.70312201
104tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68460102
105chromatin remodeling at centromere (GO:0031055)2.65874545
106establishment of protein localization to mitochondrion (GO:0072655)2.63820824
107nucleoside triphosphate biosynthetic process (GO:0009142)2.61418295
108protein localization to mitochondrion (GO:0070585)2.59740959
109L-serine metabolic process (GO:0006563)2.57789718
110cytochrome complex assembly (GO:0017004)2.51772262
111behavioral response to nicotine (GO:0035095)2.46891748
112aerobic respiration (GO:0009060)2.45554811
113purine nucleoside monophosphate biosynthetic process (GO:0009127)2.45345665
114purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.45345665
115CENP-A containing nucleosome assembly (GO:0034080)2.44742244
116proton transport (GO:0015992)2.42383976
117sequestering of actin monomers (GO:0042989)2.41983080
118mitochondrial transport (GO:0006839)2.41683074
119hydrogen transport (GO:0006818)2.37273864
120cellular component biogenesis (GO:0044085)2.34720132
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.31295146
122pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.30232247
123intracellular protein transmembrane import (GO:0044743)2.29963954
124guanosine-containing compound biosynthetic process (GO:1901070)2.29467227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.27660533
2E2F7_22180533_ChIP-Seq_HELA_Human4.04388013
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03627649
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.70176109
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.63180085
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.54051090
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.39704911
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.35806204
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07588981
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01480274
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91628781
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75917781
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73309083
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58294035
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57283346
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53762424
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49096277
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48499101
19XRN2_22483619_ChIP-Seq_HELA_Human2.47903041
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45541303
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43013126
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30900589
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28272750
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23007739
25TTF2_22483619_ChIP-Seq_HELA_Human2.20814968
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.06510057
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05838594
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98942418
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97215544
30EZH2_22144423_ChIP-Seq_EOC_Human1.96931550
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.96367629
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.94885161
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93660737
34VDR_23849224_ChIP-Seq_CD4+_Human1.88153143
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86459863
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81810316
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81800301
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.79369791
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78231565
40* SRF_21415370_ChIP-Seq_HL-1_Mouse1.78042622
41GABP_19822575_ChIP-Seq_HepG2_Human1.74140905
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69441956
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66579587
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62464134
45ELK1_19687146_ChIP-ChIP_HELA_Human1.62213671
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59519422
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.57863916
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.57512538
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.57024793
50FOXP3_21729870_ChIP-Seq_TREG_Human1.55149131
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53336511
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52798023
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46291997
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45586747
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34931836
56MYC_18940864_ChIP-ChIP_HL60_Human1.34413490
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33525055
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.32907449
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.32442299
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32341875
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32136190
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24188438
63CIITA_25753668_ChIP-Seq_RAJI_Human1.22609056
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20200028
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20171949
66* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18288161
67* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18225008
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17403442
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16567566
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.15553170
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13860251
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13379626
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12444053
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.12066584
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11399715
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10548680
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08723879
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08564381
79ZNF274_21170338_ChIP-Seq_K562_Hela1.08423686
80KDM5A_27292631_Chip-Seq_BREAST_Human1.06021266
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04687858
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04199996
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.04107577
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03584585
85IGF1R_20145208_ChIP-Seq_DFB_Human1.03231370
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02629737
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.99999846
88* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98861183
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.98726280
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.97396984
91JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97292849
92IRF1_19129219_ChIP-ChIP_H3396_Human0.95141556
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93433754
94REST_21632747_ChIP-Seq_MESCs_Mouse0.92652771
95* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92051332
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90864441
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89308337
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89174531
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89088161
100FUS_26573619_Chip-Seq_HEK293_Human0.89088045
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88876431
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87799424
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.87450473
104AR_21909140_ChIP-Seq_LNCAP_Human0.86150846
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85705071
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.85388816
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85099379
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84453399
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.84202937
110RNF2_27304074_Chip-Seq_NSC_Mouse0.83286077
111* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81880739
112VDR_22108803_ChIP-Seq_LS180_Human0.81868122
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80707394
114* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80523067
115TP53_22573176_ChIP-Seq_HFKS_Human0.78183701
116* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77551997
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.72291237
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.72031178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.75980965
2MP0001529_abnormal_vocalization3.22517517
3MP0003656_abnormal_erythrocyte_physiolo2.98047849
4MP0010030_abnormal_orbit_morphology2.68178165
5MP0003122_maternal_imprinting2.63563165
6MP0009379_abnormal_foot_pigmentation2.54139514
7MP0008789_abnormal_olfactory_epithelium2.45683483
8MP0002102_abnormal_ear_morphology2.44952891
9MP0006276_abnormal_autonomic_nervous2.44508753
10MP0003315_abnormal_perineum_morphology2.24621531
11MP0003880_abnormal_central_pattern2.19117359
12MP0006292_abnormal_olfactory_placode2.08733020
13MP0003123_paternal_imprinting2.08494530
14MP0003121_genomic_imprinting2.05076024
15MP0002653_abnormal_ependyma_morphology2.03818607
16MP0000778_abnormal_nervous_system2.00151928
17MP0005499_abnormal_olfactory_system1.99883027
18MP0005394_taste/olfaction_phenotype1.99883027
19MP0000537_abnormal_urethra_morphology1.94738309
20MP0002938_white_spotting1.92974993
21MP0002638_abnormal_pupillary_reflex1.87499937
22MP0002751_abnormal_autonomic_nervous1.82090271
23MP0000566_synostosis1.79252499
24MP0002822_catalepsy1.76291154
25MP0008932_abnormal_embryonic_tissue1.76017032
26MP0000049_abnormal_middle_ear1.71258404
27MP0004957_abnormal_blastocyst_morpholog1.68287090
28MP0003077_abnormal_cell_cycle1.64623154
29MP0001905_abnormal_dopamine_level1.62442152
30MP0003011_delayed_dark_adaptation1.55739531
31MP0001293_anophthalmia1.54319593
32MP0010094_abnormal_chromosome_stability1.52344330
33MP0003693_abnormal_embryo_hatching1.49970553
34MP0003111_abnormal_nucleus_morphology1.49758600
35MP0002736_abnormal_nociception_after1.48173218
36MP0002184_abnormal_innervation1.46862352
37MP0008995_early_reproductive_senescence1.46210255
38MP0002837_dystrophic_cardiac_calcinosis1.43292769
39MP0001968_abnormal_touch/_nociception1.43200019
40MP0004215_abnormal_myocardial_fiber1.41153627
41MP0004145_abnormal_muscle_electrophysio1.40548297
42MP0003186_abnormal_redox_activity1.40542968
43MP0000631_abnormal_neuroendocrine_gland1.33923304
44MP0004270_analgesia1.33800537
45MP0003787_abnormal_imprinting1.32852501
46MP0003385_abnormal_body_wall1.31649241
47MP0004133_heterotaxia1.31573183
48MP0002272_abnormal_nervous_system1.29587380
49MP0008058_abnormal_DNA_repair1.29320071
50MP0009053_abnormal_anal_canal1.29099712
51MP0003890_abnormal_embryonic-extraembry1.25848250
52MP0003136_yellow_coat_color1.24713202
53MP0009745_abnormal_behavioral_response1.24711551
54MP0003861_abnormal_nervous_system1.24252259
55MP0002282_abnormal_trachea_morphology1.24048116
56MP0003942_abnormal_urinary_system1.23322513
57MP0006072_abnormal_retinal_apoptosis1.21142976
58MP0002734_abnormal_mechanical_nocicepti1.19563101
59MP0003119_abnormal_digestive_system1.16480205
60MP0005423_abnormal_somatic_nervous1.15148169
61MP0001346_abnormal_lacrimal_gland1.14304020
62MP0009046_muscle_twitch1.14206880
63MP0003137_abnormal_impulse_conducting1.14191045
64MP0000751_myopathy1.13018494
65MP0003938_abnormal_ear_development1.12587050
66MP0008007_abnormal_cellular_replicative1.11610906
67MP0005646_abnormal_pituitary_gland1.11049613
68MP0002163_abnormal_gland_morphology1.10872845
69MP0006036_abnormal_mitochondrial_physio1.09420357
70MP0002064_seizures1.08699575
71MP0004142_abnormal_muscle_tone1.08573852
72MP0005377_hearing/vestibular/ear_phenot1.05922806
73MP0003878_abnormal_ear_physiology1.05922806
74MP0005551_abnormal_eye_electrophysiolog1.05476521
75MP0001486_abnormal_startle_reflex1.02689049
76MP0000026_abnormal_inner_ear1.01705008
77MP0003567_abnormal_fetal_cardiomyocyte1.01626065
78MP0006035_abnormal_mitochondrial_morpho1.01061329
79MP0002735_abnormal_chemical_nociception1.00403760
80MP0005187_abnormal_penis_morphology1.00318783
81MP0002557_abnormal_social/conspecific_i1.00093634
82MP0004742_abnormal_vestibular_system0.99093061
83MP0009250_abnormal_appendicular_skeleto0.97787636
84MP0003937_abnormal_limbs/digits/tail_de0.96822665
85MP0005253_abnormal_eye_physiology0.95560083
86MP0002152_abnormal_brain_morphology0.93852172
87MP0002249_abnormal_larynx_morphology0.93311617
88MP0002752_abnormal_somatic_nervous0.93175066
89MP0001188_hyperpigmentation0.91863956
90MP0002697_abnormal_eye_size0.91732160
91MP0003635_abnormal_synaptic_transmissio0.90617974
92MP0002733_abnormal_thermal_nociception0.90247386
93MP0004811_abnormal_neuron_physiology0.90123050
94MP0002882_abnormal_neuron_morphology0.89501385
95MP0000372_irregular_coat_pigmentation0.88624559
96MP0003786_premature_aging0.87817529
97MP0001984_abnormal_olfaction0.87745490
98MP0002063_abnormal_learning/memory/cond0.86642688
99MP0000579_abnormal_nail_morphology0.85606876
100MP0000749_muscle_degeneration0.84384567
101MP0003718_maternal_effect0.84384160
102MP0001286_abnormal_eye_development0.84112894
103MP0008057_abnormal_DNA_replication0.83115631
104MP0005645_abnormal_hypothalamus_physiol0.83015190
105MP0002067_abnormal_sensory_capabilities0.82935357
106MP0005386_behavior/neurological_phenoty0.80878953
107MP0004924_abnormal_behavior0.80878953
108MP0002233_abnormal_nose_morphology0.80069735
109MP0002210_abnormal_sex_determination0.79545336
110MP0002909_abnormal_adrenal_gland0.79319995
111MP0003221_abnormal_cardiomyocyte_apopto0.79066914
112MP0002572_abnormal_emotion/affect_behav0.78719914
113MP0000955_abnormal_spinal_cord0.77452952
114MP0002932_abnormal_joint_morphology0.77403679
115MP0000350_abnormal_cell_proliferation0.77364617
116MP0002085_abnormal_embryonic_tissue0.77075226
117MP0001485_abnormal_pinna_reflex0.76902038
118MP0002116_abnormal_craniofacial_bone0.74677474
119MP0001727_abnormal_embryo_implantation0.74157528
120MP0008877_abnormal_DNA_methylation0.73769282
121MP0004859_abnormal_synaptic_plasticity0.73450991
122MP0001730_embryonic_growth_arrest0.72866110
123MP0004085_abnormal_heartbeat0.72649618
124MP0001697_abnormal_embryo_size0.72162525
125MP0002081_perinatal_lethality0.71963954
126MP0002234_abnormal_pharynx_morphology0.71649882
127MP0008775_abnormal_heart_ventricle0.71047044
128MP0001970_abnormal_pain_threshold0.70949001
129MP0006054_spinal_hemorrhage0.70897098

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)6.71348966
2Acute necrotizing encephalopathy (HP:0006965)5.73916183
3Abnormal mitochondria in muscle tissue (HP:0008316)5.28147856
4Progressive macrocephaly (HP:0004481)4.76289161
5Mitochondrial inheritance (HP:0001427)4.74857103
6Acute encephalopathy (HP:0006846)4.32134693
7Abnormality of cells of the erythroid lineage (HP:0012130)4.29462158
8Abnormal number of erythroid precursors (HP:0012131)4.05662749
9Increased CSF lactate (HP:0002490)4.01087429
10Hepatocellular necrosis (HP:0001404)3.82766930
11Abnormality of glycolysis (HP:0004366)3.80795727
12Increased serum pyruvate (HP:0003542)3.80795727
13Myokymia (HP:0002411)3.79498328
14Increased hepatocellular lipid droplets (HP:0006565)3.58900124
15Reticulocytopenia (HP:0001896)3.27263236
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16624665
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16624665
18Lipid accumulation in hepatocytes (HP:0006561)3.11792214
19Hepatic necrosis (HP:0002605)3.03746348
20Poikilocytosis (HP:0004447)3.02514387
21Colon cancer (HP:0003003)2.84795246
22Exercise intolerance (HP:0003546)2.82207299
23Macrocytic anemia (HP:0001972)2.78656347
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73303971
25Leukodystrophy (HP:0002415)2.73164455
26Increased serum lactate (HP:0002151)2.67126358
27Optic disc pallor (HP:0000543)2.66482739
28Respiratory failure (HP:0002878)2.65352502
29Pallor (HP:0000980)2.63965815
30Renal Fanconi syndrome (HP:0001994)2.61086017
31Cerebral edema (HP:0002181)2.58934275
32Increased intramyocellular lipid droplets (HP:0012240)2.52347506
33Limb dystonia (HP:0002451)2.52286801
34Birth length less than 3rd percentile (HP:0003561)2.47040643
35Lactic acidosis (HP:0003128)2.44526661
36Hyperglycinemia (HP:0002154)2.43189950
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36135827
38Patellar aplasia (HP:0006443)2.35499919
39Abnormality of reticulocytes (HP:0004312)2.34748167
40Exertional dyspnea (HP:0002875)2.30185848
41Diaphragmatic weakness (HP:0009113)2.29462060
423-Methylglutaconic aciduria (HP:0003535)2.23667710
43Aplasia/Hypoplasia of the patella (HP:0006498)2.23634134
44Abnormal hemoglobin (HP:0011902)2.17084888
45Neuroendocrine neoplasm (HP:0100634)2.09454946
46Septo-optic dysplasia (HP:0100842)2.01606339
47Respiratory difficulties (HP:0002880)2.00577448
48Lissencephaly (HP:0001339)1.99138018
49Insomnia (HP:0100785)1.97809714
50Increased muscle lipid content (HP:0009058)1.97397388
51Hypochromic microcytic anemia (HP:0004840)1.97374011
52Pancreatic fibrosis (HP:0100732)1.96137517
53Hyperglycinuria (HP:0003108)1.95835876
54Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95232244
55Pheochromocytoma (HP:0002666)1.94845063
56Lethargy (HP:0001254)1.93264564
57Abnormal number of incisors (HP:0011064)1.93210157
58Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91552967
59Hypoplasia of the brainstem (HP:0002365)1.91552967
60Cholelithiasis (HP:0001081)1.87708802
61Emotional lability (HP:0000712)1.86936940
62Paralysis (HP:0003470)1.86714059
63Focal motor seizures (HP:0011153)1.82982145
64Reticulocytosis (HP:0001923)1.82708440
65Microvesicular hepatic steatosis (HP:0001414)1.82527491
66X-linked dominant inheritance (HP:0001423)1.79964018
67Neoplasm of the adrenal gland (HP:0100631)1.79778841
68Morphological abnormality of the middle ear (HP:0008609)1.79602186
69Abnormality of the labia minora (HP:0012880)1.79095665
70Abnormality of serine family amino acid metabolism (HP:0010894)1.78740500
71Abnormality of glycine metabolism (HP:0010895)1.78740500
72Cerebral hypomyelination (HP:0006808)1.78046172
73Hypoplasia of the pons (HP:0012110)1.77762742
74Meckel diverticulum (HP:0002245)1.76667873
75Methylmalonic aciduria (HP:0012120)1.74937684
76Methylmalonic acidemia (HP:0002912)1.74785696
77Failure to thrive in infancy (HP:0001531)1.74579285
78Delusions (HP:0000746)1.73052389
79Abnormality of the anterior horn cell (HP:0006802)1.71953957
80Degeneration of anterior horn cells (HP:0002398)1.71953957
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.70838378
82Abnormality of the ileum (HP:0001549)1.70591345
83Abnormal lung lobation (HP:0002101)1.70432334
84Cutaneous photosensitivity (HP:0000992)1.70234575
85Absent septum pellucidum (HP:0001331)1.69278545
86Short middle phalanx of the 5th finger (HP:0004220)1.69173830
87Vaginal atresia (HP:0000148)1.69078959
88Congenital primary aphakia (HP:0007707)1.68568094
89Pancreatic cysts (HP:0001737)1.67995194
90Triphalangeal thumb (HP:0001199)1.67860869
91Oral leukoplakia (HP:0002745)1.66083876
92Retinal dysplasia (HP:0007973)1.66057073
93Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64866164
94Polyphagia (HP:0002591)1.64774204
95Conjunctival hamartoma (HP:0100780)1.64350560
96Multiple enchondromatosis (HP:0005701)1.64214782
97Pendular nystagmus (HP:0012043)1.63771550
98Breast hypoplasia (HP:0003187)1.63754506
99Glycosuria (HP:0003076)1.63097265
100Abnormality of urine glucose concentration (HP:0011016)1.63097265
101Abnormality of renal resorption (HP:0011038)1.62128897
102Gout (HP:0001997)1.61147793
103Genital tract atresia (HP:0001827)1.60906563
104Horseshoe kidney (HP:0000085)1.60895989
105Poor suck (HP:0002033)1.60843289
106Nephrogenic diabetes insipidus (HP:0009806)1.59813498
107Abnormal gallbladder physiology (HP:0012438)1.59754037
108Cholecystitis (HP:0001082)1.59754037
109Hepatoblastoma (HP:0002884)1.59184536
110Abnormal gallbladder morphology (HP:0012437)1.59055463
111Gait imbalance (HP:0002141)1.57613235
112Molar tooth sign on MRI (HP:0002419)1.57184931
113Abnormality of midbrain morphology (HP:0002418)1.57184931
114Hypertensive crisis (HP:0100735)1.56791808
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.55581323
116Abnormality of the aortic arch (HP:0012303)1.55152455
117Hypothermia (HP:0002045)1.54303312
118Esotropia (HP:0000565)1.54234603
119Anophthalmia (HP:0000528)1.54216130
120Hypoplastic pelvis (HP:0008839)1.54215964
121Hypoglycemic coma (HP:0001325)1.54135897
122Aplastic anemia (HP:0001915)1.54016017
123Abnormality of the pons (HP:0007361)1.53129442
124Abnormal hair whorl (HP:0010721)1.52598428
125Hyperphosphaturia (HP:0003109)1.51628198
126Sclerocornea (HP:0000647)1.50927663
127Bilateral microphthalmos (HP:0007633)1.50458111
128Bifid tongue (HP:0010297)1.50176859
129Rib fusion (HP:0000902)1.49908640
130Hypoplastic left heart (HP:0004383)1.49566707
131CNS demyelination (HP:0007305)1.48587599
132Absent thumb (HP:0009777)1.48456409
133Abnormality of serum amino acid levels (HP:0003112)1.48117367
134Concave nail (HP:0001598)1.47430385
135Aplasia/hypoplasia of the uterus (HP:0008684)1.46701820
136High anterior hairline (HP:0009890)1.46575361
137True hermaphroditism (HP:0010459)1.46137305
138Unsteady gait (HP:0002317)1.46129687
139Acanthocytosis (HP:0001927)1.45514471
140Anencephaly (HP:0002323)1.45195753
141Rimmed vacuoles (HP:0003805)1.44994668
142Depressed nasal ridge (HP:0000457)1.44647939
143Medial flaring of the eyebrow (HP:0010747)1.43355870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.68909067
2EIF2AK13.65896278
3BUB13.33868792
4DYRK23.04347977
5STK163.00591399
6MARK12.92524619
7SRPK12.71616772
8TLK12.69384665
9DYRK32.34081591
10MAPK132.27177113
11VRK12.24200957
12LIMK12.21312276
13NME12.20328184
14CDC72.18764400
15ZAK2.14645095
16MAP3K121.92460559
17BCKDK1.88411670
18EPHA41.86495212
19UHMK11.86435570
20ERBB31.80336822
21EPHB21.79585124
22NME21.76650074
23CDK81.72438722
24BRSK11.71763181
25MAP2K71.61673924
26BCR1.58301864
27MAP4K21.57897342
28TAF11.55047381
29CDK191.54950786
30TTK1.46659700
31KSR11.45672310
32MKNK11.44405475
33PDK21.43158094
34WEE11.42891340
35NEK11.42415870
36AURKA1.41532356
37MAP3K41.41313402
38BMPR1B1.40851316
39CASK1.31832473
40SIK31.30695100
41NUAK11.28007851
42TGFBR11.25069195
43ILK1.21248547
44MYLK1.19972915
45MINK11.18310547
46PLK31.17311229
47TRIM281.16097041
48CDK181.10185664
49CCNB11.08824306
50PINK11.06876451
51CDK141.06132005
52CSNK1A1L1.03420895
53NTRK21.02157794
54BRAF1.01611531
55CDK151.00595590
56PLK10.99458517
57AURKB0.98735899
58CDK11A0.97382054
59ACVR1B0.95920566
60PLK40.93782748
61PRKD30.92659111
62CSNK1G30.92617127
63PRKCG0.87738804
64BRSK20.87481183
65YES10.86766662
66PLK20.86065700
67PBK0.82874239
68ADRBK10.82232123
69TESK10.81179527
70FGFR20.80016893
71WNK30.76598984
72TESK20.75887907
73DYRK1A0.72926877
74ABL20.72029799
75OBSCN0.71051270
76CHEK20.70332373
77GRK10.70055884
78DYRK1B0.68892749
79TSSK60.68377161
80GRK50.67130063
81PASK0.66817513
82DAPK10.63778986
83TNIK0.63363565
84STK40.62853283
85LATS20.62717934
86ERBB20.61059139
87CDK70.61035527
88MAP3K110.60655512
89NEK20.59746588
90PHKG20.59633497
91PHKG10.59633497
92CSNK2A10.58147130
93ATR0.57876285
94INSRR0.56686690
95GRK70.55904716
96CSNK1E0.54554200
97WNK40.53760162
98MAPKAPK50.53183211
99ROCK20.53142000
100PNCK0.52129135
101DAPK30.52082613
102CAMK10.51827422
103MKNK20.51326341
104ROCK10.49794096
105AKT20.49697370
106PAK10.49417352
107CSNK2A20.49120335
108PIM20.48091204
109PAK60.47825568
110LRRK20.46298959
111CSNK1G20.46260624
112MAP2K40.44849413
113ADRBK20.43497139
114EIF2AK30.43467960
115NTRK30.42651073
116MAP3K60.42509123
117PAK40.42306775
118CHEK10.42054566
119CDK10.41830123
120PAK30.39387516
121RPS6KA50.38954029
122RPS6KB20.38907294
123MAPK90.37081387
124MAPKAPK30.36477352
125CAMK2B0.35407624
126CSNK1G10.35202596
127PRKCI0.35155568
128ARAF0.33431237

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.61764076
2Ribosome_Homo sapiens_hsa030104.47394820
3Parkinsons disease_Homo sapiens_hsa050124.36178761
4Proteasome_Homo sapiens_hsa030504.07103462
5Huntingtons disease_Homo sapiens_hsa050163.26448536
6DNA replication_Homo sapiens_hsa030303.03142893
7Alzheimers disease_Homo sapiens_hsa050102.95383494
8RNA polymerase_Homo sapiens_hsa030202.90264573
9Spliceosome_Homo sapiens_hsa030402.75432909
10Mismatch repair_Homo sapiens_hsa034302.47898325
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.43875322
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41782646
13Cardiac muscle contraction_Homo sapiens_hsa042602.28183416
14Nucleotide excision repair_Homo sapiens_hsa034202.09111398
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95285669
16Pyrimidine metabolism_Homo sapiens_hsa002401.93155752
17Cell cycle_Homo sapiens_hsa041101.87603948
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85861289
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76937291
20RNA transport_Homo sapiens_hsa030131.74169494
21Fatty acid elongation_Homo sapiens_hsa000621.71059151
22Homologous recombination_Homo sapiens_hsa034401.65610797
23Base excision repair_Homo sapiens_hsa034101.64390963
24Propanoate metabolism_Homo sapiens_hsa006401.57278315
25Protein export_Homo sapiens_hsa030601.56719900
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50252830
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39420388
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36110727
29Basal transcription factors_Homo sapiens_hsa030221.33620667
30RNA degradation_Homo sapiens_hsa030181.28410069
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27671001
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26521001
33Steroid biosynthesis_Homo sapiens_hsa001001.23575580
34Systemic lupus erythematosus_Homo sapiens_hsa053221.20156078
35mRNA surveillance pathway_Homo sapiens_hsa030151.19554504
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19173235
37Alcoholism_Homo sapiens_hsa050341.19027080
38Collecting duct acid secretion_Homo sapiens_hsa049661.18807262
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16413939
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12004015
41Folate biosynthesis_Homo sapiens_hsa007901.11588167
42Vitamin B6 metabolism_Homo sapiens_hsa007501.03780250
43Arginine and proline metabolism_Homo sapiens_hsa003301.02222611
44Purine metabolism_Homo sapiens_hsa002301.01585866
45Oocyte meiosis_Homo sapiens_hsa041141.00824709
46Fanconi anemia pathway_Homo sapiens_hsa034600.99026981
47Fatty acid metabolism_Homo sapiens_hsa012120.94074176
48Peroxisome_Homo sapiens_hsa041460.90211875
49Nitrogen metabolism_Homo sapiens_hsa009100.88792407
50Non-homologous end-joining_Homo sapiens_hsa034500.88233544
51Nicotine addiction_Homo sapiens_hsa050330.84105287
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84067491
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83054884
54Synaptic vesicle cycle_Homo sapiens_hsa047210.81677783
55Axon guidance_Homo sapiens_hsa043600.78386870
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77147015
57Basal cell carcinoma_Homo sapiens_hsa052170.76148425
58Vibrio cholerae infection_Homo sapiens_hsa051100.75884402
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72393696
60Epstein-Barr virus infection_Homo sapiens_hsa051690.72277981
61One carbon pool by folate_Homo sapiens_hsa006700.72184770
62Arginine biosynthesis_Homo sapiens_hsa002200.71768501
63Fatty acid degradation_Homo sapiens_hsa000710.70409927
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.69967425
65Phenylalanine metabolism_Homo sapiens_hsa003600.68941057
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67405419
67Tryptophan metabolism_Homo sapiens_hsa003800.66601832
68Hedgehog signaling pathway_Homo sapiens_hsa043400.66483238
69beta-Alanine metabolism_Homo sapiens_hsa004100.66303243
70p53 signaling pathway_Homo sapiens_hsa041150.64530628
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61646010
72Fructose and mannose metabolism_Homo sapiens_hsa000510.61436790
73Pentose phosphate pathway_Homo sapiens_hsa000300.60554680
74Pyruvate metabolism_Homo sapiens_hsa006200.59664046
75Gap junction_Homo sapiens_hsa045400.58906915
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56628936
77Sulfur metabolism_Homo sapiens_hsa009200.54339423
78Hippo signaling pathway_Homo sapiens_hsa043900.52691272
79Serotonergic synapse_Homo sapiens_hsa047260.51982139
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.51923962
81Sulfur relay system_Homo sapiens_hsa041220.51272380
82Glutathione metabolism_Homo sapiens_hsa004800.49753929
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48870953
84Fat digestion and absorption_Homo sapiens_hsa049750.47876625
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46621102
86Selenocompound metabolism_Homo sapiens_hsa004500.45908120
87Metabolic pathways_Homo sapiens_hsa011000.45571705
88Dopaminergic synapse_Homo sapiens_hsa047280.44315493
89Bladder cancer_Homo sapiens_hsa052190.42814858
90Insulin secretion_Homo sapiens_hsa049110.41933847
91Colorectal cancer_Homo sapiens_hsa052100.41849308
92Wnt signaling pathway_Homo sapiens_hsa043100.41579908
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.39474419
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37673986
95Carbon metabolism_Homo sapiens_hsa012000.35347916
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34437557
97Vitamin digestion and absorption_Homo sapiens_hsa049770.33496297
98Phagosome_Homo sapiens_hsa041450.33026515
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32735214
100TGF-beta signaling pathway_Homo sapiens_hsa043500.32240171
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31640627
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31610235
103Viral carcinogenesis_Homo sapiens_hsa052030.31361474
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30468876
105Circadian entrainment_Homo sapiens_hsa047130.30278317
106Notch signaling pathway_Homo sapiens_hsa043300.29928205
107Melanogenesis_Homo sapiens_hsa049160.29708626
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29159195
109Melanoma_Homo sapiens_hsa052180.28995550
110Amphetamine addiction_Homo sapiens_hsa050310.28157040
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27546181
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26800781
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25591257
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22985644
115Cocaine addiction_Homo sapiens_hsa050300.22285279
116Phototransduction_Homo sapiens_hsa047440.21960507
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21766402
118Thyroid cancer_Homo sapiens_hsa052160.21219532
119GABAergic synapse_Homo sapiens_hsa047270.20524102
120Dilated cardiomyopathy_Homo sapiens_hsa054140.19115483
121Taste transduction_Homo sapiens_hsa047420.18289190
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18279092
123MicroRNAs in cancer_Homo sapiens_hsa052060.16885616
124Tight junction_Homo sapiens_hsa045300.16556550
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.15052338
126Long-term depression_Homo sapiens_hsa047300.14215945
127Biosynthesis of amino acids_Homo sapiens_hsa012300.14147562
128HTLV-I infection_Homo sapiens_hsa051660.13848485
129Butanoate metabolism_Homo sapiens_hsa006500.13722623
130Cholinergic synapse_Homo sapiens_hsa047250.13143183
131Endometrial cancer_Homo sapiens_hsa052130.13095253
132Tyrosine metabolism_Homo sapiens_hsa003500.10814724
133N-Glycan biosynthesis_Homo sapiens_hsa005100.10216310
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.10053494
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09632829
136Arachidonic acid metabolism_Homo sapiens_hsa005900.09383039
137Viral myocarditis_Homo sapiens_hsa054160.07923573

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