PRDX2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)9.06928899
2proteasome assembly (GO:0043248)8.76137595
3protein heterotetramerization (GO:0051290)7.35196861
4exocrine pancreas development (GO:0031017)7.34019092
5peptidyl-tyrosine autophosphorylation (GO:0038083)6.85655507
6DNA deamination (GO:0045006)5.50873325
7positive regulation of glycolytic process (GO:0045821)5.24506288
8endothelium development (GO:0003158)5.09840793
9male sex determination (GO:0030238)4.83174035
10positive regulation of glycogen biosynthetic process (GO:0045725)4.69164315
11regulation of respiratory burst (GO:0060263)4.34545064
12rRNA modification (GO:0000154)4.26073580
13rRNA methylation (GO:0031167)4.22740030
14positive regulation of glycogen metabolic process (GO:0070875)4.09595141
15cytidine deamination (GO:0009972)3.95827005
16cytidine metabolic process (GO:0046087)3.95827005
17cytidine catabolic process (GO:0006216)3.95827005
18cornea development in camera-type eye (GO:0061303)3.95690367
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71711371
20male meiosis (GO:0007140)3.68003968
21endoderm formation (GO:0001706)3.65211292
22sequestering of actin monomers (GO:0042989)3.61202281
23behavioral response to nicotine (GO:0035095)3.60136160
24pyrimidine ribonucleoside catabolic process (GO:0046133)3.59728936
25DNA double-strand break processing (GO:0000729)3.57597572
26piRNA metabolic process (GO:0034587)3.47397217
27activation of protein kinase B activity (GO:0032148)3.44462883
28DNA catabolic process, exonucleolytic (GO:0000738)3.39474871
29regulation of cellular amino acid metabolic process (GO:0006521)3.35944732
30positive regulation of defense response to virus by host (GO:0002230)3.34200704
31indole-containing compound catabolic process (GO:0042436)3.31870220
32indolalkylamine catabolic process (GO:0046218)3.31870220
33tryptophan catabolic process (GO:0006569)3.31870220
34L-fucose catabolic process (GO:0042355)3.31162897
35fucose catabolic process (GO:0019317)3.31162897
36L-fucose metabolic process (GO:0042354)3.31162897
37primary amino compound metabolic process (GO:1901160)3.26816340
38response to redox state (GO:0051775)3.19861483
39serotonin metabolic process (GO:0042428)3.19638734
40amine catabolic process (GO:0009310)3.17110701
41cellular biogenic amine catabolic process (GO:0042402)3.17110701
42regulation of T cell chemotaxis (GO:0010819)3.16538481
43positive regulation of T cell chemotaxis (GO:0010820)3.16538481
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.14270097
45activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.13894712
46tRNA modification (GO:0006400)3.11051063
47regulation of meiosis I (GO:0060631)3.06378700
48negative regulation of mast cell activation (GO:0033004)3.04017320
49protein K11-linked deubiquitination (GO:0035871)3.02870442
50neural tube formation (GO:0001841)3.00385617
51positive regulation of heat generation (GO:0031652)2.99588124
52water-soluble vitamin biosynthetic process (GO:0042364)2.96811007
53adenosine metabolic process (GO:0046085)2.95566096
54regulation of mitotic spindle checkpoint (GO:1903504)2.92843314
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92843314
56mitochondrial RNA metabolic process (GO:0000959)2.89082169
57tryptophan metabolic process (GO:0006568)2.87817579
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87333971
59regulation of acyl-CoA biosynthetic process (GO:0050812)2.85662452
60indole-containing compound metabolic process (GO:0042430)2.78567620
61protein complex biogenesis (GO:0070271)2.76908956
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76380612
63DNA methylation involved in gamete generation (GO:0043046)2.75684291
64preassembly of GPI anchor in ER membrane (GO:0016254)2.74684364
65branched-chain amino acid catabolic process (GO:0009083)2.73109958
66kynurenine metabolic process (GO:0070189)2.72085740
67negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.70222816
68negative regulation of protein localization to cell surface (GO:2000009)2.67079616
69tRNA processing (GO:0008033)2.66689328
70regulation of glycolytic process (GO:0006110)2.65749151
71mitochondrial respiratory chain complex assembly (GO:0033108)2.64680629
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63171099
73positive regulation of prostaglandin secretion (GO:0032308)2.62055144
74regulation of defense response to virus by host (GO:0050691)2.60713541
75platelet dense granule organization (GO:0060155)2.59412284
76signal transduction involved in cell cycle checkpoint (GO:0072395)2.59408823
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58958353
78transmission of nerve impulse (GO:0019226)2.58324431
79hematopoietic stem cell proliferation (GO:0071425)2.56871066
80negative regulation of ligase activity (GO:0051352)2.56307504
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56307504
82protein peptidyl-prolyl isomerization (GO:0000413)2.56124631
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52218594
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52218594
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52218594
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52130243
87regulation of cofactor metabolic process (GO:0051193)2.51597222
88regulation of coenzyme metabolic process (GO:0051196)2.51597222
89tyrosine phosphorylation of STAT protein (GO:0007260)2.50674763
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49801841
91indolalkylamine metabolic process (GO:0006586)2.48495750
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48149998
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48149998
94sex determination (GO:0007530)2.47654925
95ventricular trabecula myocardium morphogenesis (GO:0003222)2.47459887
96regulation of cellular amine metabolic process (GO:0033238)2.46774126
97regulation of mesenchymal cell apoptotic process (GO:2001053)2.45178782
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.43927557
99ATP synthesis coupled proton transport (GO:0015986)2.43927557
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.43511090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.99861958
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53580261
3ZNF274_21170338_ChIP-Seq_K562_Hela3.37521825
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.29456313
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25626130
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20480857
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07820106
8TAF15_26573619_Chip-Seq_HEK293_Human3.06195054
9VDR_22108803_ChIP-Seq_LS180_Human3.03971791
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57161249
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.51965157
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47425154
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.38699273
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36173462
15ELK1_19687146_ChIP-ChIP_HELA_Human2.35462965
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13110643
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.08913238
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07507429
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05862138
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00408378
21EWS_26573619_Chip-Seq_HEK293_Human1.99665870
22GBX2_23144817_ChIP-Seq_PC3_Human1.98649183
23IRF1_19129219_ChIP-ChIP_H3396_Human1.92162442
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.90345458
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83278866
26VDR_23849224_ChIP-Seq_CD4+_Human1.82211431
27FUS_26573619_Chip-Seq_HEK293_Human1.81818785
28MYC_18940864_ChIP-ChIP_HL60_Human1.77916524
29TP53_22573176_ChIP-Seq_HFKS_Human1.73927957
30P300_19829295_ChIP-Seq_ESCs_Human1.66098410
31E2F7_22180533_ChIP-Seq_HELA_Human1.64152847
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58976645
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57053453
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53692815
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51601811
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50857141
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50815973
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49914690
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49192766
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.49192766
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47691837
42EZH2_22144423_ChIP-Seq_EOC_Human1.46675400
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40824558
44FOXA1_21572438_ChIP-Seq_LNCaP_Human1.40214871
45RNF2_27304074_Chip-Seq_NSC_Mouse1.36668600
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35497629
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33615561
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33258911
49ER_23166858_ChIP-Seq_MCF-7_Human1.32618694
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32204800
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31117965
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29504732
53HTT_18923047_ChIP-ChIP_STHdh_Human1.27496609
54FOXP3_21729870_ChIP-Seq_TREG_Human1.27205716
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26531948
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24709585
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24509612
58NCOR_22424771_ChIP-Seq_293T_Human1.24120645
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23414115
60AR_20517297_ChIP-Seq_VCAP_Human1.22871484
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.22434774
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20967013
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20824914
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18579660
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18579660
66GATA3_26560356_Chip-Seq_TH2_Human1.17115702
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15143069
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14594233
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12082328
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.11212422
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.10340338
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07917473
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.05912201
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04951308
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03621825
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03255005
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03074391
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02575365
79BCAT_22108803_ChIP-Seq_LS180_Human1.02546163
80JUN_21703547_ChIP-Seq_K562_Human1.02052635
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.01515075
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.00224637
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00185330
84EED_16625203_ChIP-ChIP_MESCs_Mouse0.99845600
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99757090
86TCF4_22108803_ChIP-Seq_LS180_Human0.99594928
87AR_25329375_ChIP-Seq_VCAP_Human0.99593895
88CBP_20019798_ChIP-Seq_JUKART_Human0.99070962
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99070962
90NANOG_19829295_ChIP-Seq_ESCs_Human0.98269019
91SOX2_19829295_ChIP-Seq_ESCs_Human0.98269019
92STAT3_23295773_ChIP-Seq_U87_Human0.98205642
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97798185
94SMAD4_21799915_ChIP-Seq_A2780_Human0.96217490
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95773558
96HOXB7_26014856_ChIP-Seq_BT474_Human0.95402936
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93596269
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92881635
99TAF2_19829295_ChIP-Seq_ESCs_Human0.92197289
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.91904868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo6.05985035
2MP0005365_abnormal_bile_salt3.94108346
3MP0006072_abnormal_retinal_apoptosis3.17594430
4MP0002638_abnormal_pupillary_reflex3.16880744
5MP0005645_abnormal_hypothalamus_physiol3.15696651
6MP0003011_delayed_dark_adaptation2.94242559
7MP0004147_increased_porphyrin_level2.84326318
8MP0006276_abnormal_autonomic_nervous2.75953214
9MP0003880_abnormal_central_pattern2.69230283
10MP0009764_decreased_sensitivity_to2.44708365
11MP0002102_abnormal_ear_morphology2.18418860
12MP0003724_increased_susceptibility_to2.17562626
13MP0005671_abnormal_response_to1.94743205
14MP0006035_abnormal_mitochondrial_morpho1.90970558
15MP0001984_abnormal_olfaction1.88402319
16MP0009785_altered_susceptibility_to1.84243809
17MP0009840_abnormal_foam_cell1.76461809
18MP0005253_abnormal_eye_physiology1.75464735
19MP0002876_abnormal_thyroid_physiology1.74344053
20MP0001905_abnormal_dopamine_level1.73900104
21MP0002139_abnormal_hepatobiliary_system1.70562230
22MP0005167_abnormal_blood-brain_barrier1.62329495
23MP0008877_abnormal_DNA_methylation1.60597460
24MP0002138_abnormal_hepatobiliary_system1.55518486
25MP0009333_abnormal_splenocyte_physiolog1.54850031
26MP0008872_abnormal_physiological_respon1.52014718
27MP0001756_abnormal_urination1.47341927
28MP0004742_abnormal_vestibular_system1.45088260
29MP0005410_abnormal_fertilization1.44158548
30MP0001919_abnormal_reproductive_system1.40731266
31MP0001501_abnormal_sleep_pattern1.37197403
32MP0005551_abnormal_eye_electrophysiolog1.36988447
33MP0004885_abnormal_endolymph1.34672894
34MP0001119_abnormal_female_reproductive1.27306893
35MP0008875_abnormal_xenobiotic_pharmacok1.26328711
36MP0001929_abnormal_gametogenesis1.19283654
37MP0004043_abnormal_pH_regulation1.17968030
38MP0000465_gastrointestinal_hemorrhage1.17157404
39MP0010368_abnormal_lymphatic_system1.16566129
40MP0001486_abnormal_startle_reflex1.14104055
41MP0004134_abnormal_chest_morphology1.13971398
42MP0001879_abnormal_lymphatic_vessel1.09569449
43MP0003646_muscle_fatigue1.09187491
44MP0009745_abnormal_behavioral_response1.08515394
45MP0002751_abnormal_autonomic_nervous1.07760674
46MP0002009_preneoplasia1.05145732
47MP0005389_reproductive_system_phenotype1.03190750
48MP0002272_abnormal_nervous_system1.01696519
49MP0009765_abnormal_xenobiotic_induced1.00822277
50MP0003763_abnormal_thymus_physiology0.98241847
51MP0003698_abnormal_male_reproductive0.95585083
52MP0003121_genomic_imprinting0.95305315
53MP0010386_abnormal_urinary_bladder0.94711398
54MP0003122_maternal_imprinting0.94296980
55MP0001502_abnormal_circadian_rhythm0.93406412
56MP0000427_abnormal_hair_cycle0.91553833
57MP0009672_abnormal_birth_weight0.90796528
58MP0009046_muscle_twitch0.90361331
59MP0005448_abnormal_energy_balance0.89197235
60MP0003315_abnormal_perineum_morphology0.88935147
61MP0002067_abnormal_sensory_capabilities0.88737329
62MP0003137_abnormal_impulse_conducting0.88128823
63MP0001968_abnormal_touch/_nociception0.87952438
64MP0003943_abnormal_hepatobiliary_system0.86059387
65MP0000383_abnormal_hair_follicle0.83166489
66MP0002653_abnormal_ependyma_morphology0.82579252
67MP0002295_abnormal_pulmonary_circulatio0.79910181
68MP0005595_abnormal_vascular_smooth0.79629492
69MP0000647_abnormal_sebaceous_gland0.79443577
70MP0002735_abnormal_chemical_nociception0.78939544
71MP0002572_abnormal_emotion/affect_behav0.78573806
72MP0000358_abnormal_cell_content/0.77535748
73MP0002557_abnormal_social/conspecific_i0.77251712
74MP0002277_abnormal_respiratory_mucosa0.76251262
75MP0001145_abnormal_male_reproductive0.75757642
76MP0001944_abnormal_pancreas_morphology0.75233787
77MP0001970_abnormal_pain_threshold0.74991706
78MP0008057_abnormal_DNA_replication0.74114656
79MP0008770_decreased_survivor_rate0.73396900
80MP0000653_abnormal_sex_gland0.73289079
81MP0002693_abnormal_pancreas_physiology0.73055427
82MP0001440_abnormal_grooming_behavior0.72635074
83MP0001529_abnormal_vocalization0.72506293
84MP0002163_abnormal_gland_morphology0.72244166
85MP0002736_abnormal_nociception_after0.71580636
86MP0005195_abnormal_posterior_eye0.71257006
87MP0003718_maternal_effect0.71128815
88MP0009703_decreased_birth_body0.70514678
89MP0000778_abnormal_nervous_system0.70191621
90MP0002933_joint_inflammation0.68542242
91MP0003866_abnormal_defecation0.67965500
92MP0004133_heterotaxia0.65712557
93MP0003567_abnormal_fetal_cardiomyocyte0.65370278
94MP0005386_behavior/neurological_phenoty0.63425516
95MP0004924_abnormal_behavior0.63425516
96MP0003195_calcinosis0.63379226
97MP0001661_extended_life_span0.63230822
98MP0004883_abnormal_blood_vessel0.62874755
99MP0002210_abnormal_sex_determination0.61156873
100MP0002064_seizures0.60659903

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)8.37602420
2Hypoglycemic seizures (HP:0002173)7.46497794
3Pancreatic islet-cell hyperplasia (HP:0004510)6.81819854
4Enlarged penis (HP:0000040)6.79273645
5Hypoglycemic coma (HP:0001325)6.46434231
6Long foot (HP:0001833)6.37969321
7Elfin facies (HP:0004428)5.69844737
8Hyperinsulinemic hypoglycemia (HP:0000825)5.47922104
9Thick nail (HP:0001805)5.17492898
10Symptomatic seizures (HP:0011145)5.12102467
11Reduced subcutaneous adipose tissue (HP:0003758)4.81271294
12Insulin-resistant diabetes mellitus (HP:0000831)4.66720581
13Ketoacidosis (HP:0001993)4.06173050
14Abnormality of endocrine pancreas physiology (HP:0012093)3.94118616
15Abnormality of the pancreatic islet cells (HP:0006476)3.94118616
16Hyperglycemia (HP:0003074)3.55258376
17Growth hormone excess (HP:0000845)3.39901927
18Limb dystonia (HP:0002451)2.77481315
19Pancreatic cysts (HP:0001737)2.75859001
20Ketosis (HP:0001946)2.64067922
21Abnormal mitochondria in muscle tissue (HP:0008316)2.56368124
22Pancreatic fibrosis (HP:0100732)2.54765740
23Progressive macrocephaly (HP:0004481)2.52927773
24Acute necrotizing encephalopathy (HP:0006965)2.50093641
25Large hands (HP:0001176)2.43419675
26Lipid accumulation in hepatocytes (HP:0006561)2.40345725
27True hermaphroditism (HP:0010459)2.38942182
28Hyperventilation (HP:0002883)2.38535439
29Cerebellar dysplasia (HP:0007033)2.35018328
30Methylmalonic acidemia (HP:0002912)2.33304593
31Type II lissencephaly (HP:0007260)2.32522548
32Increased hepatocellular lipid droplets (HP:0006565)2.32021020
33Abnormality of midbrain morphology (HP:0002418)2.30090541
34Molar tooth sign on MRI (HP:0002419)2.30090541
35Decreased central vision (HP:0007663)2.29985525
36Hypothermia (HP:0002045)2.29561701
37Clitoromegaly (HP:0000057)2.26152448
38Acute encephalopathy (HP:0006846)2.12800082
39Abnormality of homocysteine metabolism (HP:0010919)2.12720461
40Homocystinuria (HP:0002156)2.12720461
41Medial flaring of the eyebrow (HP:0010747)2.08897318
42Lissencephaly (HP:0001339)2.07475910
43Insulin resistance (HP:0000855)2.06188207
44Mitochondrial inheritance (HP:0001427)2.05836295
45Methylmalonic aciduria (HP:0012120)2.04097720
46Increased corneal curvature (HP:0100692)1.96792534
47Keratoconus (HP:0000563)1.96792534
48Congenital stationary night blindness (HP:0007642)1.93593532
49Hemiplegia (HP:0002301)1.92356207
50Agitation (HP:0000713)1.92266866
51Female pseudohermaphroditism (HP:0010458)1.91071326
52Increased CSF lactate (HP:0002490)1.90267895
53Advanced eruption of teeth (HP:0006288)1.83254527
543-Methylglutaconic aciduria (HP:0003535)1.81420721
55Thyroiditis (HP:0100646)1.81159654
56Renal cortical cysts (HP:0000803)1.77385827
57Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77366919
58Hypoplasia of the pons (HP:0012110)1.70257359
59Increased intramyocellular lipid droplets (HP:0012240)1.69098125
60Cerebral edema (HP:0002181)1.67809838
61Persistence of primary teeth (HP:0006335)1.67617286
62Attenuation of retinal blood vessels (HP:0007843)1.66962054
63Focal motor seizures (HP:0011153)1.66605530
64IgG deficiency (HP:0004315)1.66250788
65Febrile seizures (HP:0002373)1.66088575
66Hypoplasia of the uterus (HP:0000013)1.65318166
67Pheochromocytoma (HP:0002666)1.63713727
68Pendular nystagmus (HP:0012043)1.63174859
69Glycosuria (HP:0003076)1.62466330
70Abnormality of urine glucose concentration (HP:0011016)1.62466330
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61474179
72Congenital primary aphakia (HP:0007707)1.61307105
73Hyperpituitarism (HP:0010514)1.61077911
74Poor speech (HP:0002465)1.60314165
75Abnormality of the vitamin B12 metabolism (HP:0004341)1.59773113
76Optic disc pallor (HP:0000543)1.59673365
77Stomach cancer (HP:0012126)1.58913290
78Abnormality of the clitoris (HP:0000056)1.58582866
79Gait imbalance (HP:0002141)1.58048524
80Aplasia/hypoplasia of the uterus (HP:0008684)1.57762403
81Furrowed tongue (HP:0000221)1.56752075
82Abnormal pupillary function (HP:0007686)1.56647345
83Thickened nuchal skin fold (HP:0000474)1.56318400
84Hemiparesis (HP:0001269)1.55753783
85Abnormality of the renal cortex (HP:0011035)1.54607174
86Abnormality of the pons (HP:0007361)1.53963619
87Conjunctival hamartoma (HP:0100780)1.52871832
88Dandy-Walker malformation (HP:0001305)1.52581518
89Abnormality of vitamin B metabolism (HP:0004340)1.52132069
90Degeneration of the lateral corticospinal tracts (HP:0002314)1.51581631
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.51581631
92Abolished electroretinogram (ERG) (HP:0000550)1.49917640
93Progressive inability to walk (HP:0002505)1.48369526
94Increased serum lactate (HP:0002151)1.48295920
95Nephrogenic diabetes insipidus (HP:0009806)1.48104349
96Polycystic ovaries (HP:0000147)1.46778549
97Renal Fanconi syndrome (HP:0001994)1.46494047
98Increased muscle lipid content (HP:0009058)1.45825371
99Optic nerve hypoplasia (HP:0000609)1.45473211
100Morphological abnormality of the inner ear (HP:0011390)1.43373668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K22.81378609
2FRK2.08735183
3INSRR13.6592845
4TSSK61.64571926
5FER1.50568986
6PINK11.44418128
7ADRBK21.44103110
8BRSK21.42680722
9NEK11.38337106
10ZAK1.34324501
11NUAK11.31626764
12BCKDK1.30353307
13FES1.23213654
14TAOK31.18539374
15EIF2AK31.14952053
16STK391.09037139
17TLK11.07871427
18PLK21.07690107
19TGFBR21.05147323
20TXK0.99786620
21MST40.97830617
22MKNK20.97409232
23KDR0.96559776
24CAMKK20.89491854
25EPHB20.86963854
26BUB10.84779198
27EPHA40.78664977
28MKNK10.78589091
29PIK3CG0.76116389
30PLK30.75258460
31NEK20.75002213
32TAF10.74689507
33PASK0.73509705
34EIF2AK10.70661670
35CSNK1G20.70169226
36WNK40.68156710
37MAP2K70.66985070
38GRK60.64627263
39CDC70.64071562
40VRK10.60406799
41ITK0.60223176
42BMPR1B0.60007265
43PTK2B0.58856941
44VRK20.57618640
45GRK10.57472424
46TGFBR10.56144541
47PRKCE0.54289869
48FLT30.53720017
49RPS6KA50.52555468
50CSNK1A1L0.50116288
51CSNK1G10.49431453
52ERBB30.49407961
53PAK30.48515025
54MYLK0.46398664
55WNK30.45975990
56MAPKAPK30.43927419
57ADRBK10.43330011
58DYRK1A0.42654437
59CSNK1G30.42038934
60PLK40.41698929
61BRSK10.41258220
62MINK10.40482793
63TIE10.40389793
64MAP4K10.40125335
65MUSK0.39722024
66IGF1R0.39161030
67CAMK2A0.38086897
68OXSR10.38059390
69SIK20.37053317
70INSR0.35987815
71DYRK20.32353496
72MAP2K20.30276703
73MET0.27369947
74LYN0.27130604
75PRKCG0.25375458
76CSNK1A10.25030210
77PDK20.24836601
78PKN10.24013356
79MAP2K60.23903179
80PRKACA0.22720872
81KIT0.22612931
82MAPK130.22502473
83ALK0.22296341
84MARK10.22048985
85BCR0.21695075
86AURKB0.21087547
87ATR0.21047378
88PHKG20.20979090
89PHKG10.20979090
90AKT30.20858132
91PRKCA0.20805176
92SRPK10.19814587
93CSK0.19380644
94NLK0.19071693
95CHUK0.18762052
96MAP3K40.18575356
97DYRK1B0.18139541
98MAPK90.16424646
99GRK50.15871393
100GRK70.15848675

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.77284919
2Protein export_Homo sapiens_hsa030603.19416797
3Phototransduction_Homo sapiens_hsa047442.91551940
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.63512122
5Parkinsons disease_Homo sapiens_hsa050122.50635748
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.44415589
7Oxidative phosphorylation_Homo sapiens_hsa001902.38012722
8Non-homologous end-joining_Homo sapiens_hsa034502.23481695
9Homologous recombination_Homo sapiens_hsa034401.93932826
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93846272
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86250879
12Steroid biosynthesis_Homo sapiens_hsa001001.83394162
13RNA polymerase_Homo sapiens_hsa030201.80648093
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72612122
15Ovarian steroidogenesis_Homo sapiens_hsa049131.72361073
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71443892
17Alzheimers disease_Homo sapiens_hsa050101.70702004
18RNA degradation_Homo sapiens_hsa030181.67417069
19Propanoate metabolism_Homo sapiens_hsa006401.67105966
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62617250
21Butanoate metabolism_Homo sapiens_hsa006501.59874740
22One carbon pool by folate_Homo sapiens_hsa006701.55937964
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54947228
24Nitrogen metabolism_Homo sapiens_hsa009101.52187808
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.51783672
26Nicotine addiction_Homo sapiens_hsa050331.48759578
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43984341
28Linoleic acid metabolism_Homo sapiens_hsa005911.42963280
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42950624
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42360798
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.37948302
32Allograft rejection_Homo sapiens_hsa053301.35634017
33Ether lipid metabolism_Homo sapiens_hsa005651.35341453
34Autoimmune thyroid disease_Homo sapiens_hsa053201.34308971
35DNA replication_Homo sapiens_hsa030301.33242095
36Basal transcription factors_Homo sapiens_hsa030221.30847563
37Fatty acid elongation_Homo sapiens_hsa000621.28180525
38Primary immunodeficiency_Homo sapiens_hsa053401.25952485
39Huntingtons disease_Homo sapiens_hsa050161.22983763
40Mismatch repair_Homo sapiens_hsa034301.22977700
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22838548
42Type I diabetes mellitus_Homo sapiens_hsa049401.21385793
43Spliceosome_Homo sapiens_hsa030401.18063215
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13796659
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11465959
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09676318
47Graft-versus-host disease_Homo sapiens_hsa053321.09558522
48Morphine addiction_Homo sapiens_hsa050321.06513061
49Folate biosynthesis_Homo sapiens_hsa007901.05703803
50Fanconi anemia pathway_Homo sapiens_hsa034601.02332334
51Tryptophan metabolism_Homo sapiens_hsa003801.01757507
52GABAergic synapse_Homo sapiens_hsa047270.96314212
53Type II diabetes mellitus_Homo sapiens_hsa049300.96263054
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95017467
55Cardiac muscle contraction_Homo sapiens_hsa042600.94772835
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92625664
57Peroxisome_Homo sapiens_hsa041460.92321657
58Chemical carcinogenesis_Homo sapiens_hsa052040.88450773
59Purine metabolism_Homo sapiens_hsa002300.86454134
60Olfactory transduction_Homo sapiens_hsa047400.81981461
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81109791
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.78368711
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71881795
64Circadian rhythm_Homo sapiens_hsa047100.69741278
65Glutamatergic synapse_Homo sapiens_hsa047240.68482491
66Regulation of autophagy_Homo sapiens_hsa041400.62456262
67Circadian entrainment_Homo sapiens_hsa047130.60709258
68Systemic lupus erythematosus_Homo sapiens_hsa053220.59755981
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56370266
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54385283
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53315775
72Rheumatoid arthritis_Homo sapiens_hsa053230.53178784
73Arginine and proline metabolism_Homo sapiens_hsa003300.52790378
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51284030
75Nucleotide excision repair_Homo sapiens_hsa034200.51067552
76Arachidonic acid metabolism_Homo sapiens_hsa005900.50610027
77Caffeine metabolism_Homo sapiens_hsa002320.50260514
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50022635
79Glycerolipid metabolism_Homo sapiens_hsa005610.49969399
80Retinol metabolism_Homo sapiens_hsa008300.48356697
81Metabolic pathways_Homo sapiens_hsa011000.46627669
82Pyrimidine metabolism_Homo sapiens_hsa002400.46338147
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.45290701
84Dopaminergic synapse_Homo sapiens_hsa047280.45181973
85Legionellosis_Homo sapiens_hsa051340.44591547
86Taste transduction_Homo sapiens_hsa047420.44458839
87Serotonergic synapse_Homo sapiens_hsa047260.40640443
88Asthma_Homo sapiens_hsa053100.38109939
89beta-Alanine metabolism_Homo sapiens_hsa004100.36005870
90Fat digestion and absorption_Homo sapiens_hsa049750.35788429
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33274706
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31784686
93Base excision repair_Homo sapiens_hsa034100.30812308
94Alcoholism_Homo sapiens_hsa050340.29811570
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29583739
96Salivary secretion_Homo sapiens_hsa049700.28796219
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27878997
98Ras signaling pathway_Homo sapiens_hsa040140.27789815
99TGF-beta signaling pathway_Homo sapiens_hsa043500.27321645
100Antigen processing and presentation_Homo sapiens_hsa046120.26682086

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