PRDX2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage morphogenesis (GO:0060536)6.59459148
2positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.59867626
3fibroblast migration (GO:0010761)5.38245377
4negative regulation of smooth muscle cell differentiation (GO:0051151)5.24744875
5response to pheromone (GO:0019236)5.14776347
6protein prenylation (GO:0018342)5.04918402
7prenylation (GO:0097354)5.04918402
8DNA integration (GO:0015074)4.61153162
9limb bud formation (GO:0060174)4.45913305
10negative regulation of vascular permeability (GO:0043116)4.27147254
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.15964308
12negative regulation of alpha-beta T cell differentiation (GO:0046639)3.99488270
13negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.98419385
14somite development (GO:0061053)3.96838831
15embryonic forelimb morphogenesis (GO:0035115)3.86608713
16organ growth (GO:0035265)3.84469529
17myoblast differentiation (GO:0045445)3.81254940
18regulation of smooth muscle cell differentiation (GO:0051150)3.70823843
19embryonic hindlimb morphogenesis (GO:0035116)3.61281499
20neutrophil activation involved in immune response (GO:0002283)3.56970276
21thalamus development (GO:0021794)3.54532816
22embryonic foregut morphogenesis (GO:0048617)3.51625349
23regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.50682129
24negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.50445966
25leukocyte migration involved in inflammatory response (GO:0002523)3.42084583
26thrombin receptor signaling pathway (GO:0070493)3.26889782
27regulation of platelet aggregation (GO:0090330)3.25834862
28carnitine transmembrane transport (GO:1902603)3.19395326
29prostate gland growth (GO:0060736)3.16459346
30forelimb morphogenesis (GO:0035136)3.14099999
31artery development (GO:0060840)3.09687065
32CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.07146389
33positive regulation of receptor recycling (GO:0001921)3.03639683
34reciprocal meiotic recombination (GO:0007131)3.03524393
35reciprocal DNA recombination (GO:0035825)3.03524393
36striated muscle atrophy (GO:0014891)3.02527196
37histone-serine phosphorylation (GO:0035404)3.01059118
38definitive hemopoiesis (GO:0060216)3.00498449
39hindbrain development (GO:0030902)2.94919687
40carnitine shuttle (GO:0006853)2.94727293
41negative regulation of axon guidance (GO:1902668)2.94696992
42retina layer formation (GO:0010842)2.94549347
43positive regulation of granulocyte differentiation (GO:0030854)2.93457476
44positive regulation of fibroblast migration (GO:0010763)2.92960737
45regulation of platelet activation (GO:0010543)2.92592433
46synaptic vesicle endocytosis (GO:0048488)2.89566451
47skeletal muscle adaptation (GO:0043501)2.88503591
48male genitalia development (GO:0030539)2.87870768
49cerebral cortex radially oriented cell migration (GO:0021799)2.87381185
50regulation of skeletal muscle contraction (GO:0014819)2.86242457
51fatty acid transmembrane transport (GO:1902001)2.84552084
52stress granule assembly (GO:0034063)2.82349337
53myelin assembly (GO:0032288)2.81852607
54negative regulation of exocytosis (GO:0045920)2.81375787
55carnitine transport (GO:0015879)2.79869884
56amino-acid betaine transport (GO:0015838)2.79869884
57negative regulation of peptidyl-lysine acetylation (GO:2000757)2.76416499
58lung lobe morphogenesis (GO:0060463)2.74774618
59regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.74769046
60hindlimb morphogenesis (GO:0035137)2.73151999
61negative regulation of alpha-beta T cell activation (GO:0046636)2.71680829
62stem cell development (GO:0048864)2.70303723
63cell proliferation involved in metanephros development (GO:0072203)2.69581901
64positive regulation of neuroblast proliferation (GO:0002052)2.69096260
65myotube differentiation (GO:0014902)2.68734387
66keratinocyte development (GO:0003334)2.68236502
67epithelial tube branching involved in lung morphogenesis (GO:0060441)2.67089513
68pathway-restricted SMAD protein phosphorylation (GO:0060389)2.65853517
69regulation of hippo signaling (GO:0035330)2.65834515
70reproductive system development (GO:0061458)2.64618980
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.62391305
72positive regulation of glycolytic process (GO:0045821)2.61145027
73positive thymic T cell selection (GO:0045059)2.60289228
74tyrosine metabolic process (GO:0006570)2.59225133
75negative regulation of histone acetylation (GO:0035067)2.57858560
76negative regulation of protein acetylation (GO:1901984)2.56750172
77retinal rod cell development (GO:0046548)2.55789775
78regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52677480
79negative thymic T cell selection (GO:0045060)2.52427772
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.52242146
81regulation of translation, ncRNA-mediated (GO:0045974)2.52242146
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52242146
83regulation of integrin-mediated signaling pathway (GO:2001044)2.51346572
84lactate metabolic process (GO:0006089)2.51342118
85dopamine transport (GO:0015872)2.51217864
86positive regulation of cAMP-mediated signaling (GO:0043950)2.51099955
87platelet aggregation (GO:0070527)2.50662274
88positive regulation of endothelial cell differentiation (GO:0045603)2.47987913
89negative regulation of complement activation (GO:0045916)2.47954238
90regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.47529138
91regulation of chemokine-mediated signaling pathway (GO:0070099)2.47391420
92regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.47241332
93positive regulation of systemic arterial blood pressure (GO:0003084)2.47107455
94histone H4-K16 acetylation (GO:0043984)2.45740810
95cellular response to ethanol (GO:0071361)2.45071701
96organelle membrane fusion (GO:0090174)2.43774354
97nucleus localization (GO:0051647)2.41508684
98positive regulation of Wnt signaling pathway (GO:0030177)2.40726121
99histone mRNA catabolic process (GO:0071044)2.40384204
100positive regulation of protein sumoylation (GO:0033235)2.38673592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.46262168
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.08381293
3SCL_19346495_ChIP-Seq_HPC-7_Human3.15161084
4GATA1_22025678_ChIP-Seq_K562_Human3.04205338
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.92501913
6GBX2_23144817_ChIP-Seq_PC3_Human2.60352825
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.37849791
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23072334
9GATA1_19941826_ChIP-Seq_K562_Human2.21022161
10SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.20579341
11GATA2_19941826_ChIP-Seq_K562_Human2.10550867
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05504932
13GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.02590310
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88748970
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85312124
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81804606
17GATA2_21666600_ChIP-Seq_HMVEC_Human1.81324266
18STAT3_23295773_ChIP-Seq_U87_Human1.78009104
19SPI1_23127762_ChIP-Seq_K562_Human1.67206946
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65714521
21TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62854948
22ER_23166858_ChIP-Seq_MCF-7_Human1.62694282
23EWS_26573619_Chip-Seq_HEK293_Human1.62510518
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.60273903
25IGF1R_20145208_ChIP-Seq_DFB_Human1.60113292
26RUNX_20019798_ChIP-Seq_JUKART_Human1.58441788
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57919176
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57407977
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56292219
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55855403
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54802623
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51289035
33SMAD4_21799915_ChIP-Seq_A2780_Human1.49947633
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49092480
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46681154
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45590927
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.44664702
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.41382792
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37209705
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37209705
41E2F7_22180533_ChIP-Seq_HELA_Human1.36807764
42AHR_22903824_ChIP-Seq_MCF-7_Human1.35386485
43TP53_16413492_ChIP-PET_HCT116_Human1.35256607
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.35253920
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.34016475
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.32334973
47TAF15_26573619_Chip-Seq_HEK293_Human1.32299879
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31460302
49VDR_24787735_ChIP-Seq_THP-1_Human1.30253369
50BCAT_22108803_ChIP-Seq_LS180_Human1.30119927
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29202709
52TCF4_23295773_ChIP-Seq_U87_Human1.23997154
53AR_25329375_ChIP-Seq_VCAP_Human1.23253618
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21321577
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19549619
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17525547
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17525547
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.16694306
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.16495793
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.16278511
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15659985
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.15025869
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11739306
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.10527319
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10092605
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09864237
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08744698
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.08615671
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.07722576
70P300_19829295_ChIP-Seq_ESCs_Human1.07543841
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06887937
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06786138
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02232857
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00491005
75FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98520809
76CJUN_26792858_Chip-Seq_BT549_Human0.97156583
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96017979
78NANOG_18555785_Chip-Seq_ESCs_Mouse0.95306611
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94870950
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94787555
81GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94279443
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.93605199
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93407371
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91033601
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90760625
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.90388806
87IRF8_27001747_Chip-Seq_BMDM_Mouse0.90330193
88TBL1_22424771_ChIP-Seq_293T_Human0.90302232
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89048851
90ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88280671
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.88093724
92GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.87553094
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86521466
94LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85307567
95EGR1_19374776_ChIP-ChIP_THP-1_Human0.84319392
96FUS_26573619_Chip-Seq_HEK293_Human0.84261612
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83710764
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83479008
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.83437884
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83387102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.64780327
2MP0003283_abnormal_digestive_organ3.80458637
3MP0000579_abnormal_nail_morphology3.55107126
4MP0002102_abnormal_ear_morphology3.53339183
5MP0005083_abnormal_biliary_tract3.43308441
6MP0000383_abnormal_hair_follicle3.23943966
7MP0005646_abnormal_pituitary_gland3.06027144
8MP0005171_absent_coat_pigmentation2.94883805
9MP0002282_abnormal_trachea_morphology2.81702601
10MP0000372_irregular_coat_pigmentation2.79525223
11MP0003646_muscle_fatigue2.68791247
12MP0001545_abnormal_hematopoietic_system2.38027285
13MP0005397_hematopoietic_system_phenotyp2.38027285
14MP0000015_abnormal_ear_pigmentation2.27565161
15MP0010678_abnormal_skin_adnexa2.25388770
16MP0001661_extended_life_span2.25357587
17MP0002234_abnormal_pharynx_morphology2.13640697
18MP0001879_abnormal_lymphatic_vessel2.12807399
19MP0004145_abnormal_muscle_electrophysio2.04596365
20MP0003656_abnormal_erythrocyte_physiolo1.85993106
21MP0005248_abnormal_Harderian_gland1.82358960
22MP0004130_abnormal_muscle_cell1.80431185
23MP0008004_abnormal_stomach_pH1.69842646
24MP0003942_abnormal_urinary_system1.59385371
25MP0002249_abnormal_larynx_morphology1.58889110
26MP0003045_fibrosis1.57099356
27MP0003950_abnormal_plasma_membrane1.54996878
28MP0000465_gastrointestinal_hemorrhage1.54695988
29MP0004381_abnormal_hair_follicle1.52515950
30MP0002295_abnormal_pulmonary_circulatio1.50941030
31MP0002396_abnormal_hematopoietic_system1.50561545
32MP0004808_abnormal_hematopoietic_stem1.46232265
33MP0003828_pulmonary_edema1.43085935
34MP0008057_abnormal_DNA_replication1.42538752
35MP0005167_abnormal_blood-brain_barrier1.41242378
36MP0003937_abnormal_limbs/digits/tail_de1.40463054
37MP0005075_abnormal_melanosome_morpholog1.39464515
38MP0004134_abnormal_chest_morphology1.36231808
39MP0009697_abnormal_copulation1.35195460
40MP0005408_hypopigmentation1.33874486
41MP0009053_abnormal_anal_canal1.29311298
42MP0010368_abnormal_lymphatic_system1.28413786
43MP0001324_abnormal_eye_pigmentation1.27936112
44MP0010307_abnormal_tumor_latency1.25007069
45MP0005253_abnormal_eye_physiology1.23500077
46MP0003724_increased_susceptibility_to1.23065688
47MP0003453_abnormal_keratinocyte_physiol1.20687693
48MP0004036_abnormal_muscle_relaxation1.16411391
49MP0000428_abnormal_craniofacial_morphol1.16389758
50MP0002160_abnormal_reproductive_system1.15734523
51MP0005187_abnormal_penis_morphology1.14701204
52MP0000569_abnormal_digit_pigmentation1.13850517
53MP0010094_abnormal_chromosome_stability1.13810334
54MP0005174_abnormal_tail_pigmentation1.12873330
55MP0005647_abnormal_sex_gland1.12552924
56MP0006292_abnormal_olfactory_placode1.12401596
57MP0002095_abnormal_skin_pigmentation1.09553516
58MP0002638_abnormal_pupillary_reflex1.09318901
59MP0008995_early_reproductive_senescence1.08534709
60MP0008872_abnormal_physiological_respon1.02305936
61MP0002128_abnormal_blood_circulation0.95613787
62MP0001851_eye_inflammation0.95075641
63MP0004084_abnormal_cardiac_muscle0.94251262
64MP0002089_abnormal_postnatal_growth/wei0.93994803
65MP0009278_abnormal_bone_marrow0.92821091
66MP0002168_other_aberrant_phenotype0.91396923
67MP0002009_preneoplasia0.87798994
68MP0002751_abnormal_autonomic_nervous0.86629133
69MP0005409_darkened_coat_color0.85689116
70MP0003091_abnormal_cell_migration0.82262722
71MP0003303_peritoneal_inflammation0.82106547
72MP0000767_abnormal_smooth_muscle0.78040123
73MP0005395_other_phenotype0.77075547
74MP0005391_vision/eye_phenotype0.75906009
75MP0000427_abnormal_hair_cycle0.72074964
76MP0006138_congestive_heart_failure0.71970502
77MP0002877_abnormal_melanocyte_morpholog0.66730502
78MP0000534_abnormal_ureter_morphology0.66353499
79MP0000230_abnormal_systemic_arterial0.65910036
80MP0004142_abnormal_muscle_tone0.65824079
81MP0001119_abnormal_female_reproductive0.64370365
82MP0000631_abnormal_neuroendocrine_gland0.64283961
83MP0003718_maternal_effect0.63176895
84MP0001175_abnormal_lung_morphology0.63119231
85MP0000371_diluted_coat_color0.63007383
86MP0004215_abnormal_myocardial_fiber0.62636943
87MP0003959_abnormal_lean_body0.60745185
88MP0002135_abnormal_kidney_morphology0.58863240
89MP0003566_abnormal_cell_adhesion0.58663437
90MP0005551_abnormal_eye_electrophysiolog0.56893591
91MP0002115_abnormal_skeleton_extremities0.56468928
92MP0001191_abnormal_skin_condition0.56300681
93MP0010030_abnormal_orbit_morphology0.55856614
94MP0005621_abnormal_cell_physiology0.55733573
95MP0005389_reproductive_system_phenotype0.55161307
96MP0003786_premature_aging0.54941360
97MP0002398_abnormal_bone_marrow0.54746951
98MP0003111_abnormal_nucleus_morphology0.54671393
99MP0002933_joint_inflammation0.53853486
100MP0005410_abnormal_fertilization0.53819073

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.46694802
2Menorrhagia (HP:0000132)5.39208740
3Increased mean platelet volume (HP:0011877)5.27049943
4Abnormal platelet volume (HP:0011876)4.80983817
5Conjunctival telangiectasia (HP:0000524)4.12596243
6Petechiae (HP:0000967)4.05468364
7Epistaxis (HP:0000421)3.88678576
8Abnormality of the vasculature of the conjunctiva (HP:0008054)3.53515364
93-Methylglutaconic aciduria (HP:0003535)3.32917022
10Aortic aneurysm (HP:0004942)3.32807244
11Abnormal number of incisors (HP:0011064)3.31232999
12Abnormal platelet function (HP:0011869)3.23594172
13Impaired platelet aggregation (HP:0003540)3.23594172
14Purpura (HP:0000979)2.99960869
15Septate vagina (HP:0001153)2.94209194
16Submucous cleft hard palate (HP:0000176)2.93178100
17Dyschromatopsia (HP:0007641)2.90664088
18Hyperventilation (HP:0002883)2.89352851
19Biliary tract neoplasm (HP:0100574)2.86197803
20Thyroiditis (HP:0100646)2.84293124
21Intestinal atresia (HP:0011100)2.79342805
22Gingival bleeding (HP:0000225)2.73376482
23Tented upper lip vermilion (HP:0010804)2.62813627
24Hyperlipoproteinemia (HP:0010980)2.54364967
25Febrile seizures (HP:0002373)2.45279817
26Obsessive-compulsive behavior (HP:0000722)2.44850096
27Prominent nose (HP:0000448)2.40396772
28Heterotopia (HP:0002282)2.38326400
29Breech presentation (HP:0001623)2.37908925
30Cone-rod dystrophy (HP:0000548)2.37884124
31Arterial tortuosity (HP:0005116)2.35228286
32Sandal gap (HP:0001852)2.32523684
33Abnormality of incisor morphology (HP:0011063)2.29602219
34Ankyloglossia (HP:0010296)2.21909275
35Agnosia (HP:0010524)2.19650662
36Astrocytoma (HP:0009592)2.12010720
37Abnormality of the astrocytes (HP:0100707)2.12010720
38Blue irides (HP:0000635)2.11676066
39Medulloblastoma (HP:0002885)2.09815841
40Abnormality of the incisor (HP:0000676)2.08814605
41Hypotelorism (HP:0000601)2.07466777
42Increased number of teeth (HP:0011069)2.06087027
43Abnormality of the renal cortex (HP:0011035)2.04967571
44Aqueductal stenosis (HP:0002410)2.04951032
45Short 5th finger (HP:0009237)2.04905916
46Poikilocytosis (HP:0004447)2.03630173
47Spontaneous hematomas (HP:0007420)2.03456256
48Widely spaced teeth (HP:0000687)2.03157138
49Growth hormone deficiency (HP:0000824)2.02249639
50Pancreatic fibrosis (HP:0100732)2.01391883
51Abnormality of oral frenula (HP:0000190)1.98551772
52Spinal muscular atrophy (HP:0007269)1.96044708
53Midline defect of the nose (HP:0004122)1.93738100
54Abnormality of the nasal septum (HP:0000419)1.93508089
55Delayed puberty (HP:0000823)1.93096568
56White forelock (HP:0002211)1.92889236
57Cutaneous melanoma (HP:0012056)1.92695666
58Complete atrioventricular canal defect (HP:0001674)1.88393611
59Bifid tongue (HP:0010297)1.87972020
60Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.87700430
61Central scotoma (HP:0000603)1.86815815
62Abnormality of the left ventricular outflow tract (HP:0011103)1.86471544
63Subaortic stenosis (HP:0001682)1.86471544
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85993026
65Short 4th metacarpal (HP:0010044)1.85993026
66Calf muscle hypertrophy (HP:0008981)1.85756862
67Anal stenosis (HP:0002025)1.85545169
68Acanthocytosis (HP:0001927)1.85256712
69Increased density of long bones (HP:0006392)1.85231602
70Vascular tortuosity (HP:0004948)1.84754332
71Rhabdomyosarcoma (HP:0002859)1.81293701
72Entropion (HP:0000621)1.81287104
73Dysdiadochokinesis (HP:0002075)1.77853934
74Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77098823
75Freckling (HP:0001480)1.76053586
76Rimmed vacuoles (HP:0003805)1.74274247
77Short chin (HP:0000331)1.74187386
78Megalencephaly (HP:0001355)1.73474255
79Renal cortical cysts (HP:0000803)1.73095300
80Pancreatic cysts (HP:0001737)1.71984896
81Oligodactyly (hands) (HP:0001180)1.71796021
82Hip dysplasia (HP:0001385)1.70765403
83Natal tooth (HP:0000695)1.70754909
84Abnormal biliary tract morphology (HP:0012440)1.70073721
85Abnormality of the heme biosynthetic pathway (HP:0010472)1.68731981
86Abnormal biliary tract physiology (HP:0012439)1.65018132
87Bile duct proliferation (HP:0001408)1.65018132
88Albinism (HP:0001022)1.64432199
89Bilateral microphthalmos (HP:0007633)1.64136145
90Enlarged kidneys (HP:0000105)1.62660111
91Hypoplastic iliac wings (HP:0002866)1.62504373
92Abnormal auditory evoked potentials (HP:0006958)1.61545877
93Hypopigmentation of the fundus (HP:0007894)1.61161402
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.60858869
95Laryngomalacia (HP:0001601)1.60763011
96Cerebral aneurysm (HP:0004944)1.60223944
97Exotropia (HP:0000577)1.59975812
98Bulbous nose (HP:0000414)1.59640327
99Muscle hypertrophy of the lower extremities (HP:0008968)1.59491175
100Highly arched eyebrow (HP:0002553)1.59421742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.80294391
2IRAK23.25372708
3CCNB13.11001416
4TGFBR22.71125871
5TLK12.58057765
6AKT32.42700449
7STK242.41973325
8ACVR1B2.33962680
9TAOK32.19061513
10IRAK12.11256404
11PIK3CG2.08126884
12CDK122.06194411
13MAP4K21.86644199
14YES11.84460502
15STK38L1.83756738
16PIK3CA1.75158931
17PLK21.74212261
18PTK2B1.63961829
19TEC1.59065859
20TNK21.52974985
21MAP3K71.51732662
22BMX1.48249165
23BTK1.47958477
24RIPK41.47117533
25STK391.41102107
26BMPR1B1.36507937
27MAP2K31.28284635
28NEK61.25003213
29MKNK21.20840660
30GRK51.18901863
31BRD41.12689401
32ZAK1.12546557
33PIM21.11440264
34PRKAA21.06431786
35CAMK1G1.06245986
36CHUK1.05863407
37STK31.05216215
38EIF2AK11.02891898
39NEK90.99293826
40PIM10.98972802
41MARK30.97635907
42TRPM70.97453218
43MKNK10.92858260
44LATS10.89377104
45ZAP700.89185993
46TAF10.86639868
47KSR10.86553415
48EPHB20.85920423
49SYK0.84912395
50FGFR30.84305412
51MTOR0.83478048
52BLK0.83072957
53BMPR20.79161155
54MAPK110.75990653
55SGK20.75413541
56GRK60.75328870
57MAPK130.74360951
58TNIK0.73476859
59ILK0.71378927
60TTN0.70397939
61HCK0.70342241
62RAF10.69125546
63MYLK0.68405432
64FER0.67717397
65MELK0.66699167
66MAP2K40.65505006
67CAMK1D0.64961396
68MAPK120.64281473
69MAP3K40.61681125
70STK40.61272278
71PRKAA10.59268186
72PKN10.58692360
73NLK0.55633131
74CDK60.55563212
75LYN0.54332653
76PLK40.53598985
77ERBB20.53470834
78NUAK10.52042597
79INSRR0.51896040
80IKBKB0.51300951
81MARK20.50493266
82CLK10.50402717
83MAPKAPK30.49334637
84OBSCN0.49269910
85CSF1R0.49214126
86RET0.47289806
87CSNK1A1L0.46207824
88FES0.44199584
89FGR0.43246858
90EEF2K0.42548972
91MAPK100.42343698
92CSNK1D0.41705290
93STK110.41429545
94ATR0.41032467
95NTRK30.40902624
96GRK10.40211117
97ERBB30.37928361
98SGK30.36552068
99ADRBK20.34564270
100CSNK1G10.34483452

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.13318681
2Platelet activation_Homo sapiens_hsa046113.03387536
3Alcoholism_Homo sapiens_hsa050342.23874549
4Phosphatidylinositol signaling system_Homo sapiens_hsa040702.15459984
5Glycerolipid metabolism_Homo sapiens_hsa005611.91018816
6Hedgehog signaling pathway_Homo sapiens_hsa043401.89256899
7Mismatch repair_Homo sapiens_hsa034301.78772496
8Inositol phosphate metabolism_Homo sapiens_hsa005621.78469052
9Endometrial cancer_Homo sapiens_hsa052131.77871287
10Colorectal cancer_Homo sapiens_hsa052101.77040504
11Chronic myeloid leukemia_Homo sapiens_hsa052201.72169979
12Fanconi anemia pathway_Homo sapiens_hsa034601.66530346
13Basal cell carcinoma_Homo sapiens_hsa052171.48181145
14mTOR signaling pathway_Homo sapiens_hsa041501.45058518
15Pancreatic cancer_Homo sapiens_hsa052121.42513008
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36462486
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29327640
18Non-small cell lung cancer_Homo sapiens_hsa052231.28973337
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.24608562
20Acute myeloid leukemia_Homo sapiens_hsa052211.22769506
21Adherens junction_Homo sapiens_hsa045201.21601845
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.19689685
23Choline metabolism in cancer_Homo sapiens_hsa052311.17712131
24Small cell lung cancer_Homo sapiens_hsa052221.15321928
25Homologous recombination_Homo sapiens_hsa034401.12785246
26ECM-receptor interaction_Homo sapiens_hsa045121.11492893
27Nitrogen metabolism_Homo sapiens_hsa009101.10983869
28Viral carcinogenesis_Homo sapiens_hsa052031.09924586
29B cell receptor signaling pathway_Homo sapiens_hsa046621.07953481
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07725505
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03589481
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99578002
33Lysine degradation_Homo sapiens_hsa003100.99550166
34Phospholipase D signaling pathway_Homo sapiens_hsa040720.99504802
35Olfactory transduction_Homo sapiens_hsa047400.99133740
36Glycosaminoglycan degradation_Homo sapiens_hsa005310.96236541
37Regulation of autophagy_Homo sapiens_hsa041400.94107485
38FoxO signaling pathway_Homo sapiens_hsa040680.93778392
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92769856
40Dorso-ventral axis formation_Homo sapiens_hsa043200.91411412
41Prostate cancer_Homo sapiens_hsa052150.91162630
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90849781
43Insulin resistance_Homo sapiens_hsa049310.90848549
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90289019
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86656266
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.86464157
47Type II diabetes mellitus_Homo sapiens_hsa049300.85069201
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83758431
49T cell receptor signaling pathway_Homo sapiens_hsa046600.83203461
50Glioma_Homo sapiens_hsa052140.81772176
51MicroRNAs in cancer_Homo sapiens_hsa052060.81308735
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81044823
53ErbB signaling pathway_Homo sapiens_hsa040120.80412737
54ABC transporters_Homo sapiens_hsa020100.79262207
55TGF-beta signaling pathway_Homo sapiens_hsa043500.77753207
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.76380413
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75421588
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74888370
59RNA polymerase_Homo sapiens_hsa030200.74680031
60Circadian rhythm_Homo sapiens_hsa047100.73603308
61Linoleic acid metabolism_Homo sapiens_hsa005910.73177421
62Focal adhesion_Homo sapiens_hsa045100.73161859
63Non-homologous end-joining_Homo sapiens_hsa034500.70291168
64Hematopoietic cell lineage_Homo sapiens_hsa046400.69996223
65Osteoclast differentiation_Homo sapiens_hsa043800.68899730
66Prolactin signaling pathway_Homo sapiens_hsa049170.68626856
67Pathways in cancer_Homo sapiens_hsa052000.68400144
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68178441
69Hippo signaling pathway_Homo sapiens_hsa043900.67868789
70VEGF signaling pathway_Homo sapiens_hsa043700.66416254
71Chemokine signaling pathway_Homo sapiens_hsa040620.64484916
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63596322
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.61931499
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61776314
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59377467
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57497578
77Melanoma_Homo sapiens_hsa052180.55596484
78Serotonergic synapse_Homo sapiens_hsa047260.54465647
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.54335908
80Hepatitis B_Homo sapiens_hsa051610.53663668
81Fatty acid biosynthesis_Homo sapiens_hsa000610.53555522
82Measles_Homo sapiens_hsa051620.53052388
83TNF signaling pathway_Homo sapiens_hsa046680.51389371
84Calcium signaling pathway_Homo sapiens_hsa040200.49850196
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.49823362
86Sphingolipid metabolism_Homo sapiens_hsa006000.49599504
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49543198
88Insulin signaling pathway_Homo sapiens_hsa049100.46953657
89Cell cycle_Homo sapiens_hsa041100.46713486
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46375328
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45382673
92Arachidonic acid metabolism_Homo sapiens_hsa005900.45379738
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43803503
94Wnt signaling pathway_Homo sapiens_hsa043100.43598233
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43465996
96Renal cell carcinoma_Homo sapiens_hsa052110.42288034
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41280531
98Long-term depression_Homo sapiens_hsa047300.39512598
99Ether lipid metabolism_Homo sapiens_hsa005650.39399529
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39026087

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